[ { "uniprot_canonical_ac": "O54865-1", "uniprot_id": [ { "id": "GCYB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54865", "type": "external" } ], "mass": 70598.0, "length": 620, "protein_name": "Guanylate cyclase soluble subunit beta-1", "gene_name": "Gucy1b1", "organism": "Mouse", "refseq_name": "guanylate cyclase soluble subunit beta-1 isoform 1", "refseq_ac": [ { "id": "NP_059497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059497", "type": "external" } ], "gene_names_uniprotkb": "Gucy1b1; Gucy1b3", "gene_names_refseq": "GC-S-beta-1; GCbeta1; Gucy1b1; Gucy1b3", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-1; 4.6.1.2; GCS-beta-1; GCS-beta-3; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit", "protein_names_refseq": "GCS-beta-1; GCS-beta-3; NO-sensitive guanylyl cyclase beta 1 subunit; beta 1 sGC; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1 isoform 1; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; soluble guanylate cyclase beta-1 subunit; soluble guanylate cyclase small subunit", "tax_id": 10090, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:54195); (R-MMU-445355)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10984516;17452643;17855621;30084848;30485489;30597209;34428180", "class_list": "", "function": "Data have provided some evidence for an alteration in the expression of alpha1 and beta1 oluble guanylyl cyclase alternative splicing forms which may contribute to the loss of sGC functions in breast cancer, [RefSeq, PubMed]; Findings identify a crucial role of the NO/sGCalpha1beta1/cGMP pathway in modulating lymphatic vessel function [soluble guanylate cyclase alpha1beta1], [RefSeq, PubMed]; GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to ischemia and reperfusion (IR) injury, and restored IR-induced cell death and apoptosis. Other results suggest that GUCY1B3 has an antiapoptotic effect and this effect is mediated by the activation of PKCepsilon and Akt., [RefSeq, PubMed]; Knockout of GCbeta1 completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor., [RefSeq, PubMed]; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0071732 cellular response to nitric oxide;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O54865-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88853-1", "uniprot_id": [ { "id": "GALR3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88853", "type": "external" } ], "mass": 40420.0, "length": 370, "protein_name": "Galanin receptor type 3", "gene_name": "Galr3", "organism": "Mouse", "refseq_name": "galanin receptor type 3", "refseq_ac": [ { "id": "NP_056553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056553", "type": "external" } ], "gene_names_uniprotkb": "Galr3; Galnr3", "gene_names_refseq": "Galnr3; Galr3", "protein_names_uniprotkb": "Galanin receptor type 3; GAL3-R; GALR-3", "protein_names_refseq": "GAL3-R; GALR-3; galanin receptor type 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14429); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "33915732", "class_list": "", "function": "Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the hormone galanin and spexin-1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RS28;E9QPX7", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097730 non-motile cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0090663 galanin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88853-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88854-1", "uniprot_id": [ { "id": "GALR2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88854", "type": "external" } ], "mass": 40516.0, "length": 371, "protein_name": "Galanin receptor type 2", "gene_name": "Galr2", "organism": "Mouse", "refseq_name": "galanin receptor type 2", "refseq_ac": [ { "id": "NP_034384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034384", "type": "external" } ], "gene_names_uniprotkb": "Galr2; Galnr2", "gene_names_refseq": "Galr2; mGalR", "protein_names_uniprotkb": "Galanin receptor type 2; GAL2-R; GALR-2", "protein_names_refseq": "GAL2-R; GALR-2; galanin receptor type 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14428); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "34428180;38726666;9832121;9832122", "class_list": "", "function": "Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i))., [UniProtKB, UniProtKB, PubMed]; Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14A53;Q9Z2B0", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0031175 neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88854-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14220-1", "uniprot_id": [ { "id": "GLPA_MOUSE", "url": "https://www.uniprot.org/uniprot/P14220", "type": "external" } ], "mass": 17664.0, "length": 168, "protein_name": "Glycophorin-A", "gene_name": "Gypa", "organism": "Mouse", "refseq_name": "glycophorin-A", "refseq_ac": [ { "id": "NP_034499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034499", "type": "external" } ], "gene_names_uniprotkb": "Gypa", "gene_names_refseq": "CD235a; GPA; Gypa", "protein_names_uniprotkb": "Glycophorin-A", "protein_names_refseq": "glycophorin-A", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365)", "pathway": " (mmu:14934)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12940824;1929437;2043106;21183079;25428506;2753361;3242812", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 8, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0047484 regulation of response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P14220-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16305-1", "uniprot_id": [ { "id": "GBRA6_MOUSE", "url": "https://www.uniprot.org/uniprot/P16305", "type": "external" } ], "mass": 51106.0, "length": 453, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-6", "gene_name": "Gabra6", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001093111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093111", "type": "external" } ], "gene_names_uniprotkb": "Gabra6; Gabra-6", "gene_names_refseq": "GABA-ARalpha6; Gabra-6; Gabra6; alpha6", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6; GABAAR subunit alpha-6", "protein_names_refseq": "GABA(A) receptor subunit alpha-6; GABAA receptor alpha 6 subunit; GABAAR subunit alpha-6; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6; gamma-aminobutyric acid receptor subunit alpha-6 isoform 1 precursor; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14399); (R-MMU-977443)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11528422;21183079;2167378", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUU5;Q9R0V3;Q9R0V4;Q9R0V5", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0050809 diazepam binding;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16305-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22933-1", "uniprot_id": [ { "id": "GBRD_MOUSE", "url": "https://www.uniprot.org/uniprot/P22933", "type": "external" } ], "mass": 50522.0, "length": 449, "protein_name": "Gamma-aminobutyric acid receptor subunit delta", "gene_name": "Gabrd", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit delta isoform 1 precursor", "refseq_ac": [ { "id": "NP_032098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032098", "type": "external" } ], "gene_names_uniprotkb": "Gabrd", "gene_names_refseq": "Gabrd", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta; GABAAR subunit delta", "protein_names_refseq": "GABA(A) receptor subunit delta; GABAAR subunit delta; gamma-aminobutyric acid receptor subunit delta isoform 1 precursor; gamma-aminobutyric acid receptor subunit delta", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); epilepsy (Disease Ontology:DOID:1826); postpartum depression (Disease Ontology:DOID:9478); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14403)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;1324097;2176788;25605945;30084848;33300544;34428180", "class_list": "", "function": "Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22933-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27681-1", "uniprot_id": [ { "id": "GBRG3_MOUSE", "url": "https://www.uniprot.org/uniprot/P27681", "type": "external" } ], "mass": 54334.0, "length": 467, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-3", "gene_name": "Gabrg3", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-3 precursor", "refseq_ac": [ { "id": "NP_032100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032100", "type": "external" } ], "gene_names_uniprotkb": "Gabrg3", "gene_names_refseq": "6330406O05Rik; B230362M20Rik; Gabrg-3; Gabrg3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-3; GABA(A) receptor subunit gamma-3; GABAAR subunit gamma-3", "protein_names_refseq": "GABAAR subunit gamma-3; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3; gamma-aminobutyric acid receptor subunit gamma-3 precursor; gamma-aminobutyric acid receptor subunit gamma-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14407); (R-MMU-977443)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;1647983;25605945", "class_list": "", "function": "Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E8E8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P27681-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35576-1", "uniprot_id": [ { "id": "G6PC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35576", "type": "external" } ], "mass": 40473.0, "length": 357, "protein_name": "Glucose-6-phosphatase catalytic subunit 1", "gene_name": "G6pc1", "organism": "Mouse", "refseq_name": "glucose-6-phosphatase catalytic subunit 1", "refseq_ac": [ { "id": "NP_032087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032087", "type": "external" } ], "gene_names_uniprotkb": "G6pc1; G6pc; G6pt", "gene_names_refseq": "G6Pase; G6pc1; G6pc; G6pt; Glc-6-Pase", "protein_names_uniprotkb": "Glucose-6-phosphatase catalytic subunit 1; 3.1.3.9; G-6-Pase; G6Pase; Glucose-6-phosphatase", "protein_names_refseq": "Glc-6-Pase-alpha; glucose-6-phosphatase catalytic subunit 1; glucose-6-phosphatase, catalytic", "tax_id": 10090, "disease": "glycogen storage disease Ia (Disease Ontology:DOID:2749); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:14377); (R-MMU-70263)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "25428506;34428180;38641253;40997131;8407995;8640227;9115220", "class_list": "glycogene", "function": "Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels., [UniProtKB, PubMed, PubMed]; Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance., [RefSeq, PubMed]; The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91WV3", "ec_number_list": [ { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor;GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0055088 lipid homeostasis;GO:0005977 glycogen metabolic process;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35576-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43029-1", "uniprot_id": [ { "id": "GDF7_MOUSE", "url": "https://www.uniprot.org/uniprot/P43029", "type": "external" } ], "mass": 47891.0, "length": 461, "protein_name": "Growth/differentiation factor 7", "gene_name": "Gdf7", "organism": "Mouse", "refseq_name": "growth/differentiation factor 7 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001299805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299805", "type": "external" } ], "gene_names_uniprotkb": "Gdf7; Gdf-7", "gene_names_refseq": "BMP12; Gdf7", "protein_names_uniprotkb": "Growth/differentiation factor 7; GDF-7", "protein_names_refseq": "GDF-7; growth/differentiation factor 7 isoform 1 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:238057)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11238730;25428506;8145850", "class_list": "", "function": "This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNX4;Q99MY1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030855 epithelial cell differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P43029-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48756-1", "uniprot_id": [ { "id": "GIP_MOUSE", "url": "https://www.uniprot.org/uniprot/P48756", "type": "external" } ], "mass": 16389.0, "length": 144, "protein_name": "Gastric inhibitory polypeptide", "gene_name": "Gip", "organism": "Mouse", "refseq_name": "gastric inhibitory polypeptide preproprotein", "refseq_ac": [ { "id": "NP_032145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032145", "type": "external" } ], "gene_names_uniprotkb": "Gip", "gene_names_refseq": "Gip", "protein_names_uniprotkb": "Gastric inhibitory polypeptide; GIP; Glucose-dependent insulinotropic polypeptide", "protein_names_refseq": "gastric inhibitory polypeptide preproprotein; glucose-dependent insulinotropic polypeptide", "tax_id": 10090, "disease": "autonomic nervous system disease (Disease Ontology:DOID:11465); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); pancreas disease (Disease Ontology:DOID:26); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14607); (R-MMU-400511); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "38653401;8764827", "class_list": "", "function": "Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion., [UniProtKB]; Stimulating intestinal GIP release reduces food intake and body weight in mice., [RefSeq, PubMed]; This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature peptides that function as potent stimulators of insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D887", "ec_number_list": [], "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031767 gastric inhibitory polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0008344 adult locomotory behavior;GO:0032024 positive regulation of insulin secretion;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48756-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58710-1", "uniprot_id": [ { "id": "GGLO_MOUSE", "url": "https://www.uniprot.org/uniprot/P58710", "type": "external" } ], "mass": 50478.0, "length": 440, "protein_name": "L-gulonolactone oxidase", "gene_name": "Gulo", "organism": "Mouse", "refseq_name": "L-gulonolactone oxidase", "refseq_ac": [ { "id": "NP_848862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848862", "type": "external" } ], "gene_names_uniprotkb": "Gulo", "gene_names_refseq": "5730581M22; GLO; Gulo; LGO; sfx; unhip; unh", "protein_names_uniprotkb": "L-gulonolactone oxidase; 1.1.3.8; GLO; L-gulono-gamma-lactone oxidase; LGO", "protein_names_refseq": "L-gulono-gamma-lactone oxidase; L-gulonolactone oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:268756)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14962674;34428180;37453647", "class_list": "", "function": "Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K152", "ec_number_list": [ { "id": "1.1.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.8", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0003885 D-arabinono-1,4-lactone oxidase activity;GO:0050105 L-gulonolactone oxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019853 L-ascorbic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P58710-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60521-1", "uniprot_id": [ { "id": "GBRL2_MOUSE", "url": "https://www.uniprot.org/uniprot/P60521", "type": "external" } ], "mass": 13667.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "Gabarapl2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor-associated protein-like 2", "refseq_ac": [ { "id": "NP_080969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080969", "type": "external" } ], "gene_names_uniprotkb": "Gabarapl2", "gene_names_refseq": "0610012F20Rik; 2900019O08Rik; GATE-16; Gabarapl2; Gef2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; GATE-16; Golgi-associated ATPase enhancer of 16 kDa", "protein_names_refseq": "GABA(A) receptor-associated protein like 2; gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2; gamma-aminobutyric acid receptor-associated protein-like 2; ganglioside expression factor 2; golgi-associated ATPase enhancer of 16 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:93739); (R-MMU-1632852); (R-MMU-8854214)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11414770;11890701;14530254;21383079;26776506;28604719;33042141;33795848;34338405;37828378;8746565", "class_list": "", "function": "Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. Gate-16 specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform distribution of interferon-inducible GTPases. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases., [RefSeq, PubMed]; Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08765;Q9DCP8;Q9UQF7", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0070972 protein localization to endoplasmic reticulum;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P60521-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63078-1", "uniprot_id": [ { "id": "GBG8_MOUSE", "url": "https://www.uniprot.org/uniprot/P63078", "type": "external" } ], "mass": 7843.0, "length": 70, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8", "gene_name": "Gng8", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8", "refseq_ac": [ { "id": "NP_034450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034450", "type": "external" } ], "gene_names_uniprotkb": "Gng8; Gng9; Gngt9", "gene_names_refseq": "G(y)8; Gng8; Hg3e", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; Gamma-9", "protein_names_refseq": "gamma-9; guanine nucleotide binding protein (G protein), gamma 8 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; heterotrimeric guanine nucleotide-binding protein 3e", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14709); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 1, "publication_id_list": "10819326", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P43426", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0043584 nose development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0035176 social behavior;GO:0071444 cellular response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63078-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70224-1", "uniprot_id": [ { "id": "GIMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70224", "type": "external" } ], "mass": 30829.0, "length": 277, "protein_name": "GTPase IMAP family member 1", "gene_name": "Gimap1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gimap1; Ian2; Imap1; Imap38", "gene_names_refseq": "", "protein_names_uniprotkb": "GTPase IMAP family member 1; IAP38; Immune-associated protein 38; Immunity-associated protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "10446218;11814688;16509771;20194894;21487483;21750661;34428180;9020038", "class_list": "", "function": "May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030183 B cell differentiation;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70224-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70348-1", "uniprot_id": [ { "id": "GCM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70348", "type": "external" } ], "mass": 49589.0, "length": 436, "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "Gcm1", "organism": "Mouse", "refseq_name": "chorion-specific transcription factor GCMa", "refseq_ac": [ { "id": "NP_032129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032129", "type": "external" } ], "gene_names_uniprotkb": "Gcm1; Gcma", "gene_names_refseq": "GCMa; Gcm-rs2; Gcm1-rs1; Gcm1; glide", "protein_names_uniprotkb": "Chorion-specific transcription factor GCMa; GCM motif protein 1; Glial cells missing homolog 1; mGCM1; mGCMa", "protein_names_refseq": "GCM motif protein 1; Gcm 1; Gcm a; chorion-specific transcription factor GCMa; glial cell deficient; mGCM1; mGCMa", "tax_id": 10090, "disease": "", "pathway": " (mmu:14531)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12682016;8814290;8962155", "class_list": "", "function": "Transcription factor that is necessary for placental development (PubMed:8962155). Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09103", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060706 cell differentiation involved in embryonic placenta development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70348-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P99025-1", "uniprot_id": [ { "id": "GFRP_MOUSE", "url": "https://www.uniprot.org/uniprot/P99025", "type": "external" } ], "mass": 9584.0, "length": 84, "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "Gchfr", "organism": "Mouse", "refseq_name": "GTP cyclohydrolase 1 feedback regulatory protein", "refseq_ac": [ { "id": "NP_796131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796131", "type": "external" } ], "gene_names_uniprotkb": "Gchfr; Gfrp", "gene_names_refseq": "2010323F13Rik; GFRP; Gchfr; P35", "protein_names_uniprotkb": "GTP cyclohydrolase 1 feedback regulatory protein; GFRP; GTP cyclohydrolase I feedback regulatory protein; p35", "protein_names_refseq": "GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320415); (R-MMU-1474151)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19286659;19926872;34428180", "class_list": "", "function": "GTPCH expression is the primary regulator of BH4 levels, and changes in GTPCH or BH4 are not necessarily accompanied by changes in GFRP expression., [RefSeq, PubMed]; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity)., [UniProtKB]; Studies provide a new mechanism for regulation of endothelial GTPCH-1 by its phosphorylation and interplay with GFRP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH29", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0044877 protein-containing complex binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0009890 negative regulation of biosynthetic process;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P99025-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07105-1", "uniprot_id": [ { "id": "GDF9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07105", "type": "external" } ], "mass": 49649.0, "length": 441, "protein_name": "Growth/differentiation factor 9", "gene_name": "Gdf9", "organism": "Mouse", "refseq_name": "growth/differentiation factor 9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032136", "type": "external" } ], "gene_names_uniprotkb": "Gdf9; Gdf-9", "gene_names_refseq": "Gdf-9; Gdf9", "protein_names_uniprotkb": "Growth/differentiation factor 9; GDF-9", "protein_names_refseq": "growth/differentiation factor 9 isoform 1 precursor", "tax_id": 10090, "disease": "primary ovarian insufficiency 14 (Disease Ontology:DOID:0080871)", "pathway": " (mmu:14566)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21970812;24357321;25428506;8186260;8429021", "class_list": "", "function": "Required for ovarian folliculogenesis., [UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030308 negative regulation of cell growth;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:2000870 regulation of progesterone secretion;GO:0001555 oocyte growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07105-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09324-1", "uniprot_id": [ { "id": "GCNT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09324", "type": "external" } ], "mass": 49839.0, "length": 428, "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase", "gene_name": "Gcnt1", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "NP_001129956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129956", "type": "external" } ], "gene_names_uniprotkb": "Gcnt1", "gene_names_refseq": "5630400D21Rik; B130048E03; C2 GlcNAcT; C2GNT; C2GlcNAcT; C2GnT-L; Gcnt1; IGnT", "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; 2.4.1.102; C2GNT; C2GlcNAcT; C2GnT-L; Core 2 beta-1,6-N-acetylglucosaminyltransferase; Core 2-branching enzyme; Core2-GlcNAc-transferase; Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase", "protein_names_refseq": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Core 2 branching enzyme) (Core2-GlcNAc-transferase) (C2GNT); beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; core 2 beta-1,6-N-acetylglucosaminyltransferase; core 2-branching enzyme; core2-GlcNAc-transferase; leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:14537); (R-MMU-913709)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12954635;16829524;22056345;32203062;34428180;7983056;9341170;9881978", "class_list": "glycogene;glycosyltransferase", "function": "Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils., [RefSeq, PubMed]; Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (PubMed:12954635, PubMed:22056345, PubMed:9881978). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (PubMed:9881978). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (PubMed:7983056). Can use Galbeta1-3GalNAcalpha1-R and Galbeta1-3GalNAcbeta1-R oligosaccharide derivatives as acceptor substrates (PubMed:7983056)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35981;Q8BRB2", "ec_number_list": [ { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0016607 nuclear speck;GO:0005802 trans-Golgi network;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:0060993 kidney morphogenesis;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0009101 glycoprotein biosynthetic process;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 2877, "hit_score": 1.4, "record_id": "Q09324-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11127-1", "uniprot_id": [ { "id": "FUT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q11127", "type": "external" } ], "mass": 49481.0, "length": 433, "protein_name": "Alpha-(1,3)-fucosyltransferase 4", "gene_name": "Fut4", "organism": "Mouse", "refseq_name": "alpha-(1,3)-fucosyltransferase 4", "refseq_ac": [ { "id": "NP_034372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034372", "type": "external" } ], "gene_names_uniprotkb": "Fut4; Elft", "gene_names_refseq": "CD15; FAL; FucT-IV; Fut4; LeX; SSEA-1; Ssea1", "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 4; 2.4.1.152; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Fuc-TIV; FucT-IV; Fucosyltransferase 4; Fucosyltransferase IV; Galactoside 3-L-fucosyltransferase", "protein_names_refseq": "3-fucosyl-N-acetyl-lactosamine epitope; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Lewis x; alpha (1,3) fucosyltransferase, myeloid specific; alpha 1,3-fucosyltransferase; alpha-(1,3)-fucosyltransferase 4; fuc-TIV; fucosyltransferase IV; galactoside 3-L-fucosyltransferase; stage-specific embryonic antigen 1", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:14345); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11485743;7559635;8882722", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:11485743). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:11485743). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (PubMed:11485743). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0032580 Golgi cisterna membrane;GO:0071944 cell periphery;GO:0005802 trans-Golgi network", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006688 glycosphingolipid biosynthetic process;GO:0006954 inflammatory response;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 1336, "hit_score": 0.4, "record_id": "Q11127-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11131-1", "uniprot_id": [ { "id": "FUT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q11131", "type": "external" } ], "mass": 44495.0, "length": 389, "protein_name": "Alpha-(1,3)-fucosyltransferase 7", "gene_name": "Fut7", "organism": "Mouse", "refseq_name": "alpha-(1,3)-fucosyltransferase 7 isoform b", "refseq_ac": [ { "id": "NP_001170837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170837", "type": "external" } ], "gene_names_uniprotkb": "Fut7", "gene_names_refseq": "FTVII; Fuc-TVII; FucT-VII; Fut7", "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 7; 2.4.1.-; Fuc-TVII; FucT-VII; Fucosyltransferase 7; Fucosyltransferase VII; Galactoside 3-L-fucosyltransferase", "protein_names_refseq": "alpha-(1,3)-fucosyltransferase 7 isoform b; alpha-(1,3)-fucosyltransferase 7; fucosyltransferase VII; galactoside 3-L-fucosyltransferase", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:14347); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10882744;10894166;11485743;11535629;12359718;15843584;21750661;8626519;8752218", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:10882744, PubMed:11485743, PubMed:11535629, PubMed:12359718, PubMed:15843584, PubMed:8626519, PubMed:8752218). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors (By similarity). However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc (By similarity). Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion (PubMed:10894166, PubMed:8752218). Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation (PubMed:10882744, PubMed:11535629, PubMed:15843584, PubMed:8752218). May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium (By similarity). May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGH5", "ec_number_list": [ { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002522 leukocyte migration involved in immune response;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 556, "hit_score": 1.0, "record_id": "Q11131-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571E4-1", "uniprot_id": [ { "id": "GALNS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571E4", "type": "external" } ], "mass": 57673.0, "length": 520, "protein_name": "N-acetylgalactosamine-6-sulfatase", "gene_name": "Galns", "organism": "Mouse", "refseq_name": "N-acetylgalactosamine-6-sulfatase isoform 2 precursor", "refseq_ac": [ { "id": "NP_001180574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180574", "type": "external" } ], "gene_names_uniprotkb": "Galns", "gene_names_refseq": "Galns; mFLJ00319", "protein_names_uniprotkb": "N-acetylgalactosamine-6-sulfatase; 3.1.6.4; Chondroitinase; Chondroitinsulfatase; GalNAc6S sulfatase; Galactose-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfate sulfatase", "protein_names_refseq": "GalNAc6S sulfatase; N-acetylgalactosamine-6-sulfatase isoform 2 precursor; N-acetylgalactosamine-6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; chondroitinase; chondroitinsulfatase; galactosamine (N-acetyl)-6-sulfate sulfatase; galactose-6-sulfate sulfatase", "tax_id": 10090, "disease": "mucopolysaccharidosis IVA (Disease Ontology:DOID:0111391); mucopolysaccharidosis IV (Disease Ontology:DOID:12804)", "pathway": " (mmu:50917); (R-MMU-2022857); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10699374;14583446;25428506;30899004", "class_list": "glycogene", "function": "Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWQ4;Q99KU8;Q9JHK9", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0043890 N-acetylgalactosamine-6-sulfatase activity;GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0030207 chondroitin sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q571E4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IXF8-1", "uniprot_id": [ { "id": "GLP2R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5IXF8", "type": "external" } ], "mass": 59105.0, "length": 512, "protein_name": "Glucagon-like peptide 2 receptor", "gene_name": "Glp2r", "organism": "Mouse", "refseq_name": "glucagon-like peptide 2 receptor precursor", "refseq_ac": [ { "id": "NP_783612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783612", "type": "external" } ], "gene_names_uniprotkb": "Glp2r", "gene_names_refseq": "9530092J08Rik; GLP-2; Glp2r", "protein_names_uniprotkb": "Glucagon-like peptide 2 receptor; GLP-2 receptor; GLP-2-R; GLP-2R", "protein_names_refseq": "G protein-coupled receptor GLP2R; GLP-2 receptor; GLP-2-R; GLP-2R; glucagon-like peptide 2 receptor precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93896); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15544847;16890611;25605945;30084848;34428180", "class_list": "", "function": "GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth Erratum:[Gastroenterology. 2007 Mar;132(3):1208], [RefSeq, PubMed, PubMed]; This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SU65", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5IXF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5JCT0-1", "uniprot_id": [ { "id": "GCNT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5JCT0", "type": "external" } ], "mass": 50698.0, "length": 437, "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3", "gene_name": "Gcnt3", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3", "refseq_ac": [ { "id": "NP_082363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082363", "type": "external" } ], "gene_names_uniprotkb": "Gcnt3", "gene_names_refseq": "2010013H22Rik; 2210021I22Rik; 2210401J11Rik; Gcnt3", "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; 2.4.1.102; 2.4.1.148; 2.4.1.150; C2GnT-M; C2GnT-mucin type; Mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase", "protein_names_refseq": "C2GnT-M; C2GnT-mucin type; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; core 2 beta-1,6-N-acetylglucosaminyltransferase II; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72077); (R-MMU-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2TIK7;Q8VCX9;Q9D8A3", "ec_number_list": [ { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:0060993 kidney morphogenesis;GO:0006493 protein O-linked glycosylation;GO:0050892 intestinal absorption", "synthesized_glycan_count": 2877, "hit_score": 0.1, "record_id": "Q5JCT0-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61012-1", "uniprot_id": [ { "id": "GBG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61012", "type": "external" } ], "mass": 8528.0, "length": 74, "protein_name": "Guanine nucleotide-binding protein G(T) subunit gamma-T1", "gene_name": "Gngt1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(T) subunit gamma-T1", "refseq_ac": [ { "id": "NP_034444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034444", "type": "external" } ], "gene_names_uniprotkb": "Gngt1; Gng1", "gene_names_refseq": "G(y)1; Gng1; Gngt1; Hg3g1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(T) subunit gamma-T1; Transducin gamma chain", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 1 subunit; guanine nucleotide-binding protein G(T) subunit gamma-T1; heterotrimeric guanine nucleotide-binding protein 3g1; transducin gamma chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:14699); (R-MMU-1296041); (R-MMU-202040); (R-MMU-2485179); (R-MMU-2514859); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 30, "publication_count": 2, "publication_id_list": "15609361;8858601", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR01", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071456 cellular response to hypoxia;GO:0008104 intracellular protein localization;GO:0010659 cardiac muscle cell apoptotic process;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61012-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61592-1", "uniprot_id": [ { "id": "GAS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61592", "type": "external" } ], "mass": 74610.0, "length": 674, "protein_name": "Growth arrest-specific protein 6", "gene_name": "Gas6", "organism": "Mouse", "refseq_name": "growth arrest-specific protein 6 precursor", "refseq_ac": [ { "id": "NP_062394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062394", "type": "external" } ], "gene_names_uniprotkb": "Gas6", "gene_names_refseq": "Gas-6; Gas6", "protein_names_uniprotkb": "Growth arrest-specific protein 6; AXL receptor tyrosine kinase ligand; GAS-6", "protein_names_refseq": "AXL receptor tyrosine kinase ligand; growth arrest-specific protein 6 precursor; growth arrest-specific protein 6", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (mmu:14456); (R-MMU-114608); (R-MMU-159763); (R-MMU-159782); (R-MMU-202733); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11175853;34428180;37828378;38786095;38928335;39046834;8336730", "class_list": "", "function": "GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes., [RefSeq, PubMed]; Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses., [UniProtKB, PubMed]; Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99K57", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0071307 cellular response to vitamin K;GO:0085029 extracellular matrix assembly;GO:0097241 hematopoietic stem cell migration to bone marrow", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SJE0-1", "uniprot_id": [ { "id": "GFRAL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6SJE0", "type": "external" } ], "mass": 43964.0, "length": 393, "protein_name": "GDNF family receptor alpha-like", "gene_name": "Gfral", "organism": "Mouse", "refseq_name": "GDNF family receptor alpha-like precursor", "refseq_ac": [ { "id": "NP_995316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995316", "type": "external" } ], "gene_names_uniprotkb": "Gfral; Gral", "gene_names_refseq": "Gfral; Gral", "protein_names_uniprotkb": "GDNF family receptor alpha-like", "protein_names_refseq": "GDNF family receptor alpha-like precursor; GDNF receptor alpha-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:404194)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "28846097;28846098;28846099;28953886;29144449;31152154;31875646;31928886;32661391;32723474;33593916;35177851;35202387;36630958;37380764", "class_list": "", "function": "Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31152154, PubMed:31928886, PubMed:32723474, PubMed:33593916, PubMed:35202387, PubMed:36630958, PubMed:37380764). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31928886, PubMed:32723474, PubMed:33593916, PubMed:35202387, PubMed:36630958). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:31875646, PubMed:31928886, PubMed:32661391, PubMed:32723474). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (PubMed:28846098, PubMed:28846099, PubMed:32723474, PubMed:33593916). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846098, PubMed:28846099, PubMed:31152154, PubMed:32723474). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:32661391)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6SJD9", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0030971 receptor tyrosine kinase binding;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0043235 receptor complex", "go_biological_process": "GO:0007399 nervous system development;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0043524 negative regulation of neuron apoptotic process;GO:0031098 stress-activated protein kinase signaling cascade", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6SJE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XP49-1", "uniprot_id": [ { "id": "GLIS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6XP49", "type": "external" } ], "mass": 83882.0, "length": 780, "protein_name": "Zinc finger protein GLIS3", "gene_name": "Glis3", "organism": "Mouse", "refseq_name": "zinc finger protein GLIS3 isoform X2", "refseq_ac": [ { "id": "XP_006527048", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006527048", "type": "external" } ], "gene_names_uniprotkb": "Glis3", "gene_names_refseq": "4833409N03Rik; E330013K21Rik; Glis3", "protein_names_uniprotkb": "Zinc finger protein GLIS3; GLI-similar 3", "protein_names_refseq": "zinc finger protein GLIS3 isoform X2", "tax_id": 10090, "disease": "neonatal diabetes mellitus with congenital hypothyroidism (Disease Ontology:DOID:0060638); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "14500813;21750661", "class_list": "", "function": "Acts both as a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BI60", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6XP49-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHJ7-1", "uniprot_id": [ { "id": "GBRA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHJ7", "type": "external" } ], "mass": 52274.0, "length": 463, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-5", "gene_name": "Gabra5", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-5 precursor", "refseq_ac": [ { "id": "NP_795916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795916", "type": "external" } ], "gene_names_uniprotkb": "Gabra5", "gene_names_refseq": "A230018I05Rik; Gabra5", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABAAR subunit alpha-5", "protein_names_refseq": "GABA(A) receptor subunit alpha-5; GABAAR subunit alpha-5; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5; gamma-aminobutyric acid receptor subunit alpha-5 precursor; gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 79 (Disease Ontology:DOID:0112215); autistic disorder (Disease Ontology:DOID:12849); depressive disorder (Disease Ontology:DOID:1596); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:110886); (R-MMU-977443)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14993607;25428506;30084848;30899004;31599954", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-5/GABRA5 are mainly extrasynaptic and contribute to the tonic GABAergic inhibition of the hippocampus (PubMed:14993607). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (PubMed:14993607)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0008306 associative learning;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BHJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN3-1", "uniprot_id": [ { "id": "GANAB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN3", "type": "external" } ], "mass": 106911.0, "length": 944, "protein_name": "Neutral alpha-glucosidase AB", "gene_name": "Ganab", "organism": "Mouse", "refseq_name": "neutral alpha-glucosidase AB isoform 2 precursor", "refseq_ac": [ { "id": "NP_001280550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280550", "type": "external" } ], "gene_names_uniprotkb": "Ganab; G2an; Kiaa0088", "gene_names_refseq": "G2an; Ganab; GluII; mKIAA0088", "protein_names_uniprotkb": "Neutral alpha-glucosidase AB; 3.2.1.207; Alpha-glucosidase 2; Glucosidase II subunit alpha", "protein_names_refseq": "alpha-glucosidase 2; carbohydrate processing enzyme of the endoplasmic reticulum; glucosidase II alpha-subunit; glucosidase II subunit alpha; neutral alpha-glucosidase AB isoform 2 precursor; neutral alpha-glucosidase AB", "tax_id": 10090, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 3 (Disease Ontology:DOID:0110860)", "pathway": " (mmu:14376); (R-MMU-9768727)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10921916;26495903;26740625;27462106;28011936;28375157;31219806;31616917;32550232;33725478;34428180;37828378;39627609;9148925", "class_list": "glycogene;glycosylhydrolase", "function": "Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:28375157)., [UniProtKB, PubMed, PubMed]; Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08794;Q149A6;Q80U81;Q9CS53", "ec_number_list": [ { "id": "3.2.1.207", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.207", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033919 glucan 1,3-alpha-glucosidase activity;GO:0090599 alpha-glucosidase activity;GO:0015926 glucosidase activity;GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0042470 melanosome;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BHN3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVW0-1", "uniprot_id": [ { "id": "GANC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVW0", "type": "external" } ], "mass": 102008.0, "length": 898, "protein_name": "Neutral alpha-glucosidase C", "gene_name": "Ganc", "organism": "Mouse", "refseq_name": "neutral alpha-glucosidase C", "refseq_ac": [ { "id": "NP_766260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766260", "type": "external" } ], "gene_names_uniprotkb": "Ganc", "gene_names_refseq": "5830445O15Rik; 9330160A12; Ganc; mFLJ00088", "protein_names_uniprotkb": "Neutral alpha-glucosidase C; 3.2.1.20", "protein_names_refseq": "neutral alpha-glucosidase C", "tax_id": 10090, "disease": "", "pathway": " (mmu:76051)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Has alpha-glucosidase activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH03", "ec_number_list": [], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0090599 alpha-glucosidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006491 N-glycan processing;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVW0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7B6-1", "uniprot_id": [ { "id": "FXL22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7B6", "type": "external" } ], "mass": 26320.0, "length": 236, "protein_name": "F-box and leucine-rich protein 22", "gene_name": "Fbxl22", "organism": "Mouse", "refseq_name": "F-box and leucine-rich protein 22", "refseq_ac": [ { "id": "NP_780415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780415", "type": "external" } ], "gene_names_uniprotkb": "Fbxl22", "gene_names_refseq": "1110004B15Rik; Fbxl22", "protein_names_uniprotkb": "F-box and leucine-rich protein 22", "protein_names_refseq": "F-box and leucine-rich protein 22; F-box/LRR-repeat protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:74165)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22972877;32783651", "class_list": "", "function": "Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3G3;Q8C3V6", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0030018 Z disc", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C7B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFA2-1", "uniprot_id": [ { "id": "GCST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFA2", "type": "external" } ], "mass": 44009.0, "length": 403, "protein_name": "Aminomethyltransferase, mitochondrial", "gene_name": "Amt", "organism": "Mouse", "refseq_name": "aminomethyltransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001013836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013836", "type": "external" } ], "gene_names_uniprotkb": "Amt", "gene_names_refseq": "Amt; EG434437; GCVT", "protein_names_uniprotkb": "Aminomethyltransferase, mitochondrial; 2.1.2.10; GCVT; Glycine cleavage system T protein", "protein_names_refseq": "aminomethyltransferase, mitochondrial precursor; aminomethyltransferase, mitochondrial; glycine cleavage system T protein", "tax_id": 10090, "disease": "glycine encephalopathy 2 (Disease Ontology:DOID:0061001); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (mmu:434437); (R-MMU-6783984)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12487019;23806337;34428180", "class_list": "", "function": "The glycine cleavage system catalyzes the degradation of glycine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.10", "type": "external" } ], "go_molecular_function": "GO:0008483 transaminase activity;GO:0004047 aminomethyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFB4-1", "uniprot_id": [ { "id": "GBP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFB4", "type": "external" } ], "mass": 66930.0, "length": 590, "protein_name": "Guanylate-binding protein 5", "gene_name": "Gbp5", "organism": "Mouse", "refseq_name": "guanylate-binding protein 5", "refseq_ac": [ { "id": "NP_705792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705792", "type": "external" } ], "gene_names_uniprotkb": "Gbp5", "gene_names_refseq": "5330409J06Rik; Gbp5a; Gbp5", "protein_names_uniprotkb": "Guanylate-binding protein 5; 3.6.5.-; GBP-5; GTP-binding protein 5; Guanine nucleotide-binding protein 5; MuGBP-5", "protein_names_refseq": "GBP-5; GTP-binding protein 5; guanine nucleotide-binding protein 5; guanylate nucleotide binding protein 5; guanylate-binding protein 5; muGBP-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:229898); (R-MMU-9953170)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12396730;18025219;19224205;20173027;22461501;24715728;24739961;25774715;25774716;27693356;30589883;34428180;38404575;38531874;38642025;39062588", "class_list": "", "function": "Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of GBP5 activates autophagy to alleviate inflammatory response in LPS-induced lung injury in mice., [RefSeq, PubMed]; Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22461501, PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro., [RefSeq, PubMed]; Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJR4;Q8CFA4;Q8CFA8", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032741 positive regulation of interleukin-18 production;GO:0006954 inflammatory response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CFB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R322-1", "uniprot_id": [ { "id": "GLE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R322", "type": "external" } ], "mass": 79574.0, "length": 699, "protein_name": "mRNA export factor GLE1", "gene_name": "Gle1", "organism": "Mouse", "refseq_name": "mRNA export factor GLE1", "refseq_ac": [ { "id": "NP_083199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083199", "type": "external" } ], "gene_names_uniprotkb": "Gle1; Gle1l", "gene_names_refseq": "4933405K21Rik; Gle1l; Gle1", "protein_names_uniprotkb": "mRNA export factor GLE1; GLE1 RNA export mediator; GLE1-like protein; Nucleoporin GLE1", "protein_names_refseq": "GLE1-like protein; mRNA export factor GLE1; nucleoporin GLE1", "tax_id": 10090, "disease": "lethal congenital contracture syndrome 1 (Disease Ontology:DOID:0060559)", "pathway": " (mmu:74412); (R-MMU-159236)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17242355", "class_list": "", "function": "Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGV8;Q3TT10;Q3TU23;Q3UD65;Q8BT16;Q9D4A6", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0000822 inositol hexakisphosphate binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R322-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC60-1", "uniprot_id": [ { "id": "GLB1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC60", "type": "external" } ], "mass": 73279.0, "length": 646, "protein_name": "Beta-galactosidase-1-like protein", "gene_name": "Glb1l", "organism": "Mouse", "refseq_name": "beta-galactosidase-1-like protein precursor", "refseq_ac": [ { "id": "NP_083286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083286", "type": "external" } ], "gene_names_uniprotkb": "Glb1l", "gene_names_refseq": "4833408P15Rik; Glb1l", "protein_names_uniprotkb": "Beta-galactosidase-1-like protein; 3.2.1.23", "protein_names_refseq": "beta-galactosidase-1-like protein precursor; beta-galactosidase-1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74577); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDK6;Q9D631", "ec_number_list": [ { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" } ], "go_molecular_function": "GO:0004565 beta-galactosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005615 extracellular space;GO:0005773 vacuole", "go_biological_process": "GO:0019388 galactose catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VC60-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI38-1", "uniprot_id": [ { "id": "GBGT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI38", "type": "external" } ], "mass": 40502.0, "length": 347, "protein_name": "Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1", "gene_name": "Gbgt1", "organism": "Mouse", "refseq_name": "globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_631936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631936", "type": "external" } ], "gene_names_uniprotkb": "Gbgt1; Fgs", "gene_names_refseq": "Fgs; Fs; Gbgt1", "protein_names_uniprotkb": "Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; 2.4.1.88; Forssman glycolipid synthase", "protein_names_refseq": "forssman glycolipid synthase; forssman glycolipid synthetase; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227671)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14573676;30084848;30779550;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:14573676). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens (PubMed:14573676). Conversely, it diminishes Shiga toxins susceptibility (PubMed:14573676)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KPA1;Q8CJF3", "ec_number_list": [ { "id": "2.4.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.88", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0001575 globoside metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VI38-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W61-1", "uniprot_id": [ { "id": "FXL15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W61", "type": "external" } ], "mass": 33125.0, "length": 300, "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "Fbxl15", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 15 isoform 1", "refseq_ac": [ { "id": "NP_598455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598455", "type": "external" } ], "gene_names_uniprotkb": "Fbxl15; Fbxo37", "gene_names_refseq": "0710008C12Rik; Fbxl15; Fbxo37", "protein_names_uniprotkb": "F-box/LRR-repeat protein 15; F-box only protein 37", "protein_names_refseq": "F-box only protein 37; F-box/LRR-repeat protein 15 isoform 1; F-box/LRR-repeat protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:68431); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21572392", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9R4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91W61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WK5-1", "uniprot_id": [ { "id": "GCSH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WK5", "type": "external" } ], "mass": 18637.0, "length": 170, "protein_name": "Glycine cleavage system H protein, mitochondrial", "gene_name": "Gcsh", "organism": "Mouse", "refseq_name": "glycine cleavage system H protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080848", "type": "external" } ], "gene_names_uniprotkb": "Gcsh", "gene_names_refseq": "1100001L02Rik; 5730591C18Rik; Gcsh", "protein_names_uniprotkb": "Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein", "protein_names_refseq": "glycine cleavage system H protein, mitochondrial precursor; glycine cleavage system H protein, mitochondrial; lipoic acid-containing protein", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome (Disease Ontology:DOID:0070330); amino acid metabolic disorder (Disease Ontology:DOID:9252); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (mmu:68133); (R-MMU-6783984); (R-MMU-9857492)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "28135057", "class_list": "", "function": "The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY75;Q9D197", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0004047 aminomethyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P50-1", "uniprot_id": [ { "id": "GHSR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P50", "type": "external" } ], "mass": 40969.0, "length": 364, "protein_name": "Growth hormone secretagogue receptor type 1", "gene_name": "Ghsr", "organism": "Mouse", "refseq_name": "growth hormone secretagogue receptor type 1", "refseq_ac": [ { "id": "NP_796304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796304", "type": "external" } ], "gene_names_uniprotkb": "Ghsr", "gene_names_refseq": "C530020I22Rik; GHRP; GHS-R; Ghsr1a; Ghsr", "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; GHRP; GHS-R; Ghrelin receptor", "protein_names_refseq": "G-protein coupled receptor; GH-releasing peptide receptor; ghrelin receptor; growth hormone secretagogue receptor type 1", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:208188); (R-MMU-416476)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (By similarity). Upon activation, stimulates appetite and promotes growth hormone secretion (By similarity). Also binds other growth hormone releasing peptides (GHRP) as well as non-peptide, low molecular weight secretagogues (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWX8;Q91Z82", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding;GO:0001616 growth hormone secretagogue receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0098794 postsynapse", "go_biological_process": "GO:0060123 regulation of growth hormone secretion;GO:1903672 positive regulation of sprouting angiogenesis;GO:0032100 positive regulation of appetite;GO:0120058 positive regulation of small intestinal transit;GO:1904000 positive regulation of eating behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99P50-1", "record_type": "protein", "filter_code": "0000000.1000011.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY6-1", "uniprot_id": [ { "id": "GID4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY6", "type": "external" } ], "mass": 24863.0, "length": 217, "protein_name": "Glucose-induced degradation protein 4 homolog", "gene_name": "Gid4", "organism": "Mouse", "refseq_name": "glucose-induced degradation protein 4 homolog", "refseq_ac": [ { "id": "NP_080033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080033", "type": "external" } ], "gene_names_uniprotkb": "Gid4", "gene_names_refseq": "4933439F18Rik; Gid4", "protein_names_uniprotkb": "Glucose-induced degradation protein 4 homolog; Vacuolar import and degradation protein 24 homolog", "protein_names_refseq": "glucose-induced degradation protein 4 homolog; vacuolar import and degradation protein 24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66771); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP79;Q7TT31;Q99JE9", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CPY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQS6-1", "uniprot_id": [ { "id": "GKN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQS6", "type": "external" } ], "mass": 20469.0, "length": 184, "protein_name": "Gastrokine-2", "gene_name": "Gkn2", "organism": "Mouse", "refseq_name": "gastrokine-2 precursor", "refseq_ac": [ { "id": "NP_079743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079743", "type": "external" } ], "gene_names_uniprotkb": "Gkn2; Blot", "gene_names_refseq": "1810036H07Rik; Bricd1b; Gkn2", "protein_names_uniprotkb": "Gastrokine-2; Blottin", "protein_names_refseq": "blottin; gastrokine-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66284)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16888721;25290738;32226647", "class_list": "", "function": "Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the NLRP3 Inflammasome., [RefSeq, PubMed]; Yolk sac endothelial cells were found to express low levels of Gkn2 transcript and protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0045178 basal part of cell", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006954 inflammatory response;GO:0042127 regulation of cell population proliferation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR36-1", "uniprot_id": [ { "id": "GKN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR36", "type": "external" } ], "mass": 20134.0, "length": 184, "protein_name": "Gastrokine-1", "gene_name": "Gkn1", "organism": "Mouse", "refseq_name": "gastrokine-1 precursor", "refseq_ac": [ { "id": "NP_079742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079742", "type": "external" } ], "gene_names_uniprotkb": "Gkn1; Amp18; Ca11", "gene_names_refseq": "2200002K21Rik; AMP-18; BRICD1; Fov; Gkn1", "protein_names_uniprotkb": "Gastrokine-1; 18 kDa antrum mucosa protein; AMP-18; Protein CA11 homolog", "protein_names_refseq": "18 kDa antrum mucosa protein; foveolin; gastrokine-1 precursor; protein CA11 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66283)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12851218;15221938", "class_list": "", "function": "Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTZ5;Q9D7K7", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CR36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR59-1", "uniprot_id": [ { "id": "G45IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR59", "type": "external" } ], "mass": 25820.0, "length": 222, "protein_name": "Large ribosomal subunit protein mL64", "gene_name": "Gadd45gip1", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL64", "refseq_ac": [ { "id": "NP_899202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899202", "type": "external" } ], "gene_names_uniprotkb": "Gadd45gip1; Mrpl59", "gene_names_refseq": "2310040G17Rik; Crif1; Gadd45gip1; MRP-L59; Plinp1", "protein_names_uniprotkb": "Large ribosomal subunit protein mL64; 39S ribosomal protein L59, mitochondrial; Growth arrest and DNA damage-inducible proteins-interacting protein 1; MRP-L59", "protein_names_refseq": "39S ribosomal protein L59, mitochondrial; growth arrest and DNA damage-inducible proteins-interacting protein 1; large ribosomal subunit protein mL64; papillomavirus L2 interacting nuclear protein 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:102060); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18200042;19801644;22819524;37648779;38597829", "class_list": "", "function": "Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis., [UniProtKB, UniProtKB]; CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane., [RefSeq, PubMed]; Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Erratum:[Mol Psychiatry. 2023 Oct;28(10):4485. doi: 10.1038/s41380-023-02254-1. PMID: 37783789], [RefSeq, PubMed]; Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability., [RefSeq, PubMed]; Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function., [RefSeq, PubMed]; Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT05", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXP8-1", "uniprot_id": [ { "id": "GBG10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXP8", "type": "external" } ], "mass": 7229.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10", "gene_name": "Gng10", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10", "refseq_ac": [ { "id": "NP_079553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079553", "type": "external" } ], "gene_names_uniprotkb": "Gng10", "gene_names_refseq": "Gng10; Hg3m1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10; heterotrimeric guanine nucleotide-binding protein 3m1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14700); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 1, "publication_id_list": "32152506", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALW6;Q56A84", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CXP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZN8-1", "uniprot_id": [ { "id": "GATA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZN8", "type": "external" } ], "mass": 56783.0, "length": 525, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "gene_name": "Qrsl1", "organism": "Mouse", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "refseq_ac": [ { "id": "NP_001074523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074523", "type": "external" } ], "gene_names_uniprotkb": "Qrsl1", "gene_names_refseq": "2700038P16Rik; GatA; Qrsl1", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; 6.3.5.7; Glu-AdT subunit A; Glutaminyl-tRNA synthase-like protein 1", "protein_names_refseq": "glu-AdT subunit A; glutaminyl-tRNA synthase-like protein 1; glutamyl-tRNA(Gln) amidotransferase subunit A homolog; glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 40 (Disease Ontology:DOID:0112117)", "pathway": " (mmu:76563)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDF6;Q6NS53", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CZN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0T7-1", "uniprot_id": [ { "id": "GKN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0T7", "type": "external" } ], "mass": 20772.0, "length": 191, "protein_name": "Gastrokine-3", "gene_name": "Gkn3", "organism": "Mouse", "refseq_name": "gastrokine-3 precursor", "refseq_ac": [ { "id": "NP_081136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081136", "type": "external" } ], "gene_names_uniprotkb": "Gkn3", "gene_names_refseq": "1190003M12Rik; Gkn3", "protein_names_uniprotkb": "Gastrokine-3", "protein_names_refseq": "gastrokine-3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68888)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20138039;28604600", "class_list": "", "function": "Gkn3 encodes a novel, functionally distinct gastrokine that is overexpressed and might restrain epithelial cell proliferation in gastric atrophy., [RefSeq, PubMed]; Gkn3, Fcgbp, and Muc2 might be involved in the transient disruption of the splenic architecture and its reorganization, which is characteristic after Toxoplasma gondii infection. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits gastric epithelial cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0T7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4F8-1", "uniprot_id": [ { "id": "GCP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4F8", "type": "external" } ], "mass": 76126.0, "length": 667, "protein_name": "Gamma-tubulin complex component 4", "gene_name": "Tubgcp4", "organism": "Mouse", "refseq_name": "gamma-tubulin complex component 4 isoform a", "refseq_ac": [ { "id": "NP_700436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700436", "type": "external" } ], "gene_names_uniprotkb": "Tubgcp4; D2Ertd435e; Gcp4", "gene_names_refseq": "4932441P04Rik; 76p; D2Ertd435e; GCP-4; Tubgcp4", "protein_names_uniprotkb": "Gamma-tubulin complex component 4; GCP-4", "protein_names_refseq": "gamma tubulin ring complex protein; gamma-tubulin complex component 4 isoform a; gamma-tubulin complex component 4; tubulin, gamma complex associated protein 4", "tax_id": 10090, "disease": "microcephaly and chorioretinopathy 3 (Disease Ontology:DOID:0080107)", "pathway": " (mmu:51885); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16751367;31209365;31219806;34428180", "class_list": "", "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB]; Gamma-tubulin forms complexes with Fyn and Syk kinases and other signal transduction molecules in the process of bone marrow-derived mast cell activation., [RefSeq, PubMed]; Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0055037 recycling endosome;GO:0000930 gamma-tubulin complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D4F8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8I3-1", "uniprot_id": [ { "id": "GLOD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8I3", "type": "external" } ], "mass": 16595.0, "length": 148, "protein_name": "Glyoxalase domain-containing protein 5", "gene_name": "Glod5", "organism": "Mouse", "refseq_name": "glyoxalase domain-containing protein 5", "refseq_ac": [ { "id": "NP_081503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081503", "type": "external" } ], "gene_names_uniprotkb": "Glod5", "gene_names_refseq": "2010001H14Rik; Glod5", "protein_names_uniprotkb": "Glyoxalase domain-containing protein 5", "protein_names_refseq": "glyoxalase domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69824)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D8I3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB41-1", "uniprot_id": [ { "id": "GHC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB41", "type": "external" } ], "mass": 34166.0, "length": 320, "protein_name": "Mitochondrial glutamate carrier 2", "gene_name": "Slc25a18", "organism": "Mouse", "refseq_name": "mitochondrial glutamate carrier 2", "refseq_ac": [ { "id": "NP_001074517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074517", "type": "external" } ], "gene_names_uniprotkb": "Slc25a18; Gc2", "gene_names_refseq": "1500015I14Rik; Slc25a18", "protein_names_uniprotkb": "Mitochondrial glutamate carrier 2; GC-2; Glutamate/H(+) symporter 2; Solute carrier family 25 member 18", "protein_names_refseq": "GC-2; glutamate/H(+) symporter 2; mitochondrial glutamate carrier 2; solute carrier family 25 member 18", "tax_id": 10090, "disease": "intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (mmu:71803); (R-MMU-442660); (R-MMU-9856872)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12865426;34428180", "class_list": "", "function": "Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RPU3;Q14AI5", "ec_number_list": [], "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DB41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV56-1", "uniprot_id": [ { "id": "GDF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV56", "type": "external" } ], "mass": 47703.0, "length": 428, "protein_name": "Growth/differentiation factor 2", "gene_name": "Gdf2", "organism": "Mouse", "refseq_name": "growth/differentiation factor 2 preproprotein", "refseq_ac": [ { "id": "NP_062379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062379", "type": "external" } ], "gene_names_uniprotkb": "Gdf2; Bmp9", "gene_names_refseq": "Bmp9; Gdf2", "protein_names_uniprotkb": "Growth/differentiation factor 2; BMP-9; Bone morphogenetic protein 9; GDF-2", "protein_names_refseq": "bone morphogenetic protein 9; growth/differentiation factor 2 preproprotein", "tax_id": 10090, "disease": "hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270)", "pathway": " (mmu:12165); (R-MMU-201451)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23300529;25428506;25751889;38502919;38885771", "class_list": "", "function": "BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations., [RefSeq, PubMed]; Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney injury through inhibition of renal VEGFA., [RefSeq, PubMed]; Potent circulating inhibitor of angiogenesis (By similarity). Signals through the type I activin receptor ACVRL1 but not other Alks (PubMed:25751889). Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG (PubMed:23300529)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAS6;Q9QZE0", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WV56-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0J7-1", "uniprot_id": [ { "id": "GDF15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0J7", "type": "external" } ], "mass": 33225.0, "length": 303, "protein_name": "Growth/differentiation factor 15", "gene_name": "Gdf15", "organism": "Mouse", "refseq_name": "growth/differentiation factor 15 preproprotein", "refseq_ac": [ { "id": "NP_001317616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317616", "type": "external" } ], "gene_names_uniprotkb": "Gdf15; Mic1; Sbf", "gene_names_refseq": "Gdf15; MIC-1; NAG-1; SBF", "protein_names_uniprotkb": "Growth/differentiation factor 15; GDF-15; MIC-1; Macrophage inhibitory cytokine 1", "protein_names_refseq": "growth/differentiation factor 15 preproprotein; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1", "tax_id": 10090, "disease": "anemia (Disease Ontology:DOID:2355)", "pathway": " (mmu:23886)", "pathway_count": 1, "publication_count": 39, "publication_id_list": "10779363;12514175;15897808;17982462;19864576;21516086;23468844;27986797;28081177;28572090;28846097;28846098;28846099;28953886;29026214;29046435;29144449;30070999;30639358;31152154;31875646;31928886;32026535;32661391;32694673;32723474;33207247;33589633;33593916;33758420;34187898;35202387;36001956;36465107;37380764;37433299;37437602;38056430;38092039", "class_list": "", "function": "GDF-15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK, [RefSeq, PubMed]; GDF-15/MIC-1 is an early mediator of the injury response in kidney and lung, [RefSeq, PubMed]; Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite (PubMed:23468844, PubMed:27986797, PubMed:28572090, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29026214, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:31928886, PubMed:32026535, PubMed:32694673, PubMed:32723474, PubMed:33589633, PubMed:33593916, PubMed:33758420, PubMed:34187898, PubMed:36465107, PubMed:37433299, PubMed:37437602, PubMed:38056430, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:23468844, PubMed:28572090, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:33589633, PubMed:33593916, PubMed:37437602, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31152154, PubMed:31928886, PubMed:33593916, PubMed:37380764). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:27986797, PubMed:32661391). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (PubMed:37437602). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (PubMed:37380764). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:32694673, PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea and contributing to malnutrition (PubMed:31928886, PubMed:33207247, PubMed:35202387). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:17982462, PubMed:32661391, PubMed:32723474). Responsible for the risk of nausea during pregnancy: high levels of GDF15 during pregnancy, mostly originating from embryos, are associated with increased nausea (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, females with naturally high level of GDF15 being less susceptible to nausea than female mice with low levels of GDF15 before pregnancy (By similarity). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (By similarity). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (PubMed:21516086). Inhibits growth hormone signaling on hepatocytes (PubMed:28572090)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NX63", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002686 negative regulation of leukocyte migration;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9Z0J7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0L8-1", "uniprot_id": [ { "id": "GGH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0L8", "type": "external" } ], "mass": 35470.0, "length": 317, "protein_name": "Gamma-glutamyl hydrolase", "gene_name": "Ggh", "organism": "Mouse", "refseq_name": "gamma-glutamyl hydrolase precursor", "refseq_ac": [ { "id": "NP_034411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034411", "type": "external" } ], "gene_names_uniprotkb": "Ggh", "gene_names_refseq": "Ggh; gamma-GH", "protein_names_uniprotkb": "Gamma-glutamyl hydrolase; 3.4.19.9; Conjugase; FGPH; Folylpolyglutamate hydrolase; GH; Gamma-Glu-x carboxypeptidase", "protein_names_refseq": "FGPH; GH; conjugase; folylpolyglutamate hydrolase; gamma-Glu-x carboxypeptidase; gamma-glutamyl hydrolase precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14590); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10393243;16170054;30899004;9756990", "class_list": "", "function": "Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AWC1;Q9Z0L7", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0034722 gamma-glutamyl-peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0042470 melanosome;GO:0005773 vacuole", "go_biological_process": "GO:0046900 tetrahydrofolylpolyglutamate metabolic process;GO:0010043 response to zinc ion;GO:0045471 response to ethanol;GO:0032868 response to insulin;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0L8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2H7-1", "uniprot_id": [ { "id": "GIPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2H7", "type": "external" } ], "mass": 34118.0, "length": 314, "protein_name": "PDZ domain-containing protein GIPC2", "gene_name": "Gipc2", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein GIPC2", "refseq_ac": [ { "id": "NP_058563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058563", "type": "external" } ], "gene_names_uniprotkb": "Gipc2; Semcap2", "gene_names_refseq": "2200002N01Rik; Gipc2; Semcap2", "protein_names_uniprotkb": "PDZ domain-containing protein GIPC2; SEMCAP-2; SemaF cytoplasmic domain-associated protein 2", "protein_names_refseq": "PDZ domain-containing protein GIPC2; SEMCAP-2; semaF cytoplasmic domain associated protein 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:54120)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10318831;30084848;31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVG2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2H7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Z9-1", "uniprot_id": [ { "id": "GFPT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Z9", "type": "external" } ], "mass": 77009.0, "length": 682, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "gene_name": "Gfpt2", "organism": "Mouse", "refseq_name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "refseq_ac": [ { "id": "NP_038557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038557", "type": "external" } ], "gene_names_uniprotkb": "Gfpt2", "gene_names_refseq": "GFAT2; Gfpt2", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; 2.6.1.16; D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; Glutamine:fructose-6-phosphate amidotransferase 2; Hexosephosphate aminotransferase 2", "protein_names_refseq": "D-fructose-6-phosphate amidotransferase 2; GFAT 2; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine:fructose-6-phosphate amidotransferase 2; hexosephosphate aminotransferase 2", "tax_id": 10090, "disease": "Machado-Joseph disease (Disease Ontology:DOID:1440); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14584); (R-MMU-446210)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10198162;15133036;21183079;30084848;30254013;32978282;34428180", "class_list": "glycogene", "function": "Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins., [UniProtKB]; Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked beta-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages., [RefSeq, PubMed]; Mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) is phosphorylated by cAMP-dependent protein kinase, which increases the enzyme activity, [RefSeq, PubMed]; These results support a model wherein high fat diet increases retinal protein O-GlcNAcylation by promoting NR4A1-dependent GFAT2 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCL2", "ec_number_list": [ { "id": "2.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.16", "type": "external" } ], "go_molecular_function": "GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006487 protein N-linked glycosylation;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006541 glutamine metabolic process;GO:0006047 UDP-N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2Z9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A535-1", "uniprot_id": [ { "id": "MELT_MOUSE", "url": "https://www.uniprot.org/uniprot/A1A535", "type": "external" } ], "mass": 94502.0, "length": 833, "protein_name": "Ventricular zone-expressed PH domain-containing protein 1", "gene_name": "Veph1", "organism": "Mouse", "refseq_name": "ventricular zone-expressed PH domain-containing protein 1", "refseq_ac": [ { "id": "NP_665819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665819", "type": "external" } ], "gene_names_uniprotkb": "Veph1; Veph", "gene_names_refseq": "2810471M23Rik; Veph1; Veph", "protein_names_uniprotkb": "Ventricular zone-expressed PH domain-containing protein 1; Protein melted homolog", "protein_names_refseq": "protein melted homolog; ventricular zone-expressed PH domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72789)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15388229;25428506;32612287", "class_list": "", "function": "Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling., [UniProtKB, UniProtKB]; MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice., [RefSeq, PubMed]; Veph was strongly expressed in the ventricular zone of the embryonic brain, and its expression level gradually decreased in later stages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP23;Q8K4P5;Q8K4P6;Q9CYR8", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1A535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02853-1", "uniprot_id": [ { "id": "MMP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02853", "type": "external" } ], "mass": 55441.0, "length": 492, "protein_name": "Stromelysin-3", "gene_name": "Mmp11", "organism": "Mouse", "refseq_name": "stromelysin-3 preproprotein", "refseq_ac": [ { "id": "NP_001293113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293113", "type": "external" } ], "gene_names_uniprotkb": "Mmp11", "gene_names_refseq": "MMP-11; Mmp11; SL-3; ST3; Stmy3", "protein_names_uniprotkb": "Stromelysin-3; 3.4.24.-; MMP-11; Matrix metalloproteinase-11; SL-3; ST3", "protein_names_refseq": "matrix metalloproteinase 11; stromelysin 3; stromelysin-3 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:17385); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11254383;1429845;21750661;25428506;34428180;37828378", "class_list": "", "function": "May play an important role in the progression of epithelial malignancies., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0045599 negative regulation of fat cell differentiation;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02853-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08574-1", "uniprot_id": [ { "id": "MESP2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08574", "type": "external" } ], "mass": 39789.0, "length": 370, "protein_name": "Mesoderm posterior protein 2", "gene_name": "Mesp2", "organism": "Mouse", "refseq_name": "mesoderm posterior protein 2", "refseq_ac": [ { "id": "NP_032615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032615", "type": "external" } ], "gene_names_uniprotkb": "Mesp2", "gene_names_refseq": "Mesp2; bHLHc6", "protein_names_uniprotkb": "Mesoderm posterior protein 2", "protein_names_refseq": "mesoderm posterior protein 2", "tax_id": 10090, "disease": "spondylocostal dysostosis 2 (Disease Ontology:DOID:0112362)", "pathway": " (mmu:17293)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10330372;10887078;10932180;11562355;12591245;12900443;15677726;15902259;16505380;16728472;16996494;17306789;17360776;17477400;35025872;9242490", "class_list": "", "function": "Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Also regulates the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Also controls the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIV5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O08574-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27106-1", "uniprot_id": [ { "id": "AMH_MOUSE", "url": "https://www.uniprot.org/uniprot/P27106", "type": "external" } ], "mass": 59244.0, "length": 554, "protein_name": "Anti-Muellerian hormone", "gene_name": "Amh", "organism": "Mouse", "refseq_name": "anti-Muellerian hormone precursor", "refseq_ac": [ { "id": "NP_031471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031471", "type": "external" } ], "gene_names_uniprotkb": "Amh", "gene_names_refseq": "Amh; MIS", "protein_names_uniprotkb": "Anti-Muellerian hormone; AMH; MIS; Muellerian-inhibiting factor; Muellerian-inhibiting substance", "protein_names_refseq": "Mullerian inhibiting substance; anti-Muellerian hormone precursor; anti-Muellerian hormone; muellerian-inhibiting factor; muellerian-inhibiting substance", "tax_id": 10090, "disease": "persistent Mullerian duct syndrome (Disease Ontology:DOID:0050791); polycystic ovary syndrome (Disease Ontology:DOID:11612); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); granulosa cell tumor (Disease Ontology:DOID:2999); ovarian carcinoma (Disease Ontology:DOID:4001); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11705); (R-MMU-201451)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11606457;11861535;1782869;21750661;34418053;7954809;8541848;9435237", "class_list": "", "function": "Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11606457, PubMed:11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (PubMed:11606457, PubMed:11861535, PubMed:1782869, PubMed:9435237). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (PubMed:1782869, PubMed:9435237). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11606457, PubMed:11861535). Also plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A7E2R1;Q5EC55", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007530 sex determination;GO:2000355 negative regulation of ovarian follicle development;GO:0010628 positive regulation of gene expression;GO:0001655 urogenital system development;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P27106-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41317-1", "uniprot_id": [ { "id": "MBL2_MOUSE", "url": "https://www.uniprot.org/uniprot/P41317", "type": "external" } ], "mass": 25957.0, "length": 244, "protein_name": "Mannose-binding protein C", "gene_name": "Mbl2", "organism": "Mouse", "refseq_name": "mannose-binding protein C precursor", "refseq_ac": [ { "id": "NP_034906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034906", "type": "external" } ], "gene_names_uniprotkb": "Mbl2", "gene_names_refseq": "L-MBP; MBL-C; MBL; MBP-C; Mbl2; RARF/P28A", "protein_names_uniprotkb": "Mannose-binding protein C; MBP-C; Mannan-binding protein; RA-reactive factor P28A subunit; RARF/P28A", "protein_names_refseq": "RA-reactive factor P28A subunit; mannan-binding protein; mannose binding lectin, liver (C); mannose-binding protein C precursor; mannose-binding protein C", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); disease by infectious agent (Disease Ontology:DOID:0050117); Kartagener syndrome (Disease Ontology:DOID:0050144); chorioamnionitis (Disease Ontology:DOID:0050697); respiratory allergy (Disease Ontology:DOID:0060496); Cryptococcal meningitis (Disease Ontology:DOID:0080159); lupus nephritis (Disease Ontology:DOID:0080162); Coronavirus infectious disease (Disease Ontology:DOID:0080599); sensorineural hearing loss (Disease Ontology:DOID:10003); dermatomyositis (Disease Ontology:DOID:10223); bacterial infectious disease (Disease Ontology:DOID:104); Legionnaires' disease (Disease Ontology:DOID:10457); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); otitis media (Disease Ontology:DOID:10754); lepromatous leprosy (Disease Ontology:DOID:10887); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); common variable immunodeficiency (Disease Ontology:DOID:12177); vitiligo (Disease Ontology:DOID:12306); bronchopneumonia (Disease Ontology:DOID:12375); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); coccidioidomycosis (Disease Ontology:DOID:13450); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); fungal infectious disease (Disease Ontology:DOID:1564); thrombocytopenia (Disease Ontology:DOID:1588); cryptosporidiosis (Disease Ontology:DOID:1733); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); vulvovaginal candidiasis (Disease Ontology:DOID:2272); leptospirosis (Disease Ontology:DOID:2297); ovarian cancer (Disease Ontology:DOID:2394); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); bacterial vaginosis (Disease Ontology:DOID:3385); peripheral vascular disease (Disease Ontology:DOID:341); pulmonary fibrosis (Disease Ontology:DOID:3770); liver disease (Disease Ontology:DOID:409); coronary restenosis (Disease Ontology:DOID:4247); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); aortic valve insufficiency (Disease Ontology:DOID:57); panic disorder (Disease Ontology:DOID:594); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188); end stage renal disease (Disease Ontology:DOID:783); polymyalgia rheumatica (Disease Ontology:DOID:853); herpes simplex (Disease Ontology:DOID:8566); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); pemphigus (Disease Ontology:DOID:9182); bronchiectasis (Disease Ontology:DOID:9563); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17195); (R-MMU-166662)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1712818;26495903;26740625;38062244;7766991", "class_list": "glycogene", "function": "Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway., [UniProtKB, UniProtKB]; The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 72, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005771 multivesicular body;GO:0032991 protein-containing complex;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0010954 positive regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41317-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56942-1", "uniprot_id": [ { "id": "MCH_MOUSE", "url": "https://www.uniprot.org/uniprot/P56942", "type": "external" } ], "mass": 18516.0, "length": 165, "protein_name": "Pro-MCH", "gene_name": "Pmch", "organism": "Mouse", "refseq_name": "pro-MCH preproprotein", "refseq_ac": [ { "id": "NP_084247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084247", "type": "external" } ], "gene_names_uniprotkb": "Pmch; Mch", "gene_names_refseq": "A230109K23Rik; Pmch", "protein_names_uniprotkb": "Pro-MCH", "protein_names_refseq": "neuropeptide-glutamic acid-isoleucine (NEI); neuropeptide-glycine-glutamic acid (NGE); pro-MCH preproprotein; pro-MCH", "tax_id": 10090, "disease": "sleeping sickness (Disease Ontology:DOID:10112); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:110312); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10037747;1327720;38806249;38874572;39390522;8637571;8724342;9872314", "class_list": "", "function": "Inhibitory actions of melanin-concentrating hormone in the lateral septum., [RefSeq, PubMed]; Melanin concentrating hormone regulates the JNK/ERK signaling pathway to alleviate influenza A virus infection-induced neuroinflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways (By similarity). Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep (PubMed:8637571). Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity. Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis. Antagonizes NEI-induced behavioral effects (By similarity). May also participate in spermatocyte differentiation (PubMed:8724342)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Neuropeptide that modulates stress-related neuroendocrine responses and behaviors. Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized. Reduces dopamine and DOPAC release in the ventromedial nucleus. Influences differentiation of neuronal processes and affects neurofilament protein content in vitro., [UniProtKB, UniProtKB]; Rat prepro-MCH is processed into three neuropeptides: melanin-concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and Neuropeptide-glycine-glutamic acid (NGE)., [RefSeq, PubMed]; Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone. Erratum:[J Neurosci. 2024 Oct 16:e1832242024. doi: 10.1523/JNEUROSCI.1832-24.2024. PMID: 39414378] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]., [RefSeq]; This study showed increased expression of MCH mRNA with fasting and in mice lacking leptin. It also demonstrated that administration of MCH in the lateral ventricle leads to increased feeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D220", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030354 melanin-concentrating hormone activity;GO:0031777 type 1 melanin-concentrating hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0045202 synapse", "go_biological_process": "GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10738-1", "uniprot_id": [ { "id": "MMP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q10738", "type": "external" } ], "mass": 29755.0, "length": 264, "protein_name": "Matrilysin", "gene_name": "Mmp7", "organism": "Mouse", "refseq_name": "matrilysin isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_034940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034940", "type": "external" } ], "gene_names_uniprotkb": "Mmp7", "gene_names_refseq": "MAT; MMP-7; Mmp7", "protein_names_uniprotkb": "Matrilysin; 3.4.24.23; MMP-7; Matrin; Matrix metalloproteinase-7; Pump-1 protease; Uterine metalloproteinase", "protein_names_refseq": "matrilysin isoform 1 preproprotein; matrilysin, uterine; matrin; matrix metalloproteinase 7; pump-1 protease; uterine metalloproteinase", "tax_id": 10090, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); glioblastoma (Disease Ontology:DOID:3068); lung non-small cell carcinoma (Disease Ontology:DOID:3908); coronary restenosis (Disease Ontology:DOID:4247)", "pathway": " (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-2022090); (R-MMU-9009391)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22510880;7579699", "class_list": "", "function": "Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity)., [UniProtKB]; May play a role in tissue reorganization., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q10738-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZ45-1", "uniprot_id": [ { "id": "MCIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZ45", "type": "external" } ], "mass": 41148.0, "length": 379, "protein_name": "Multicilin", "gene_name": "Mcidas", "organism": "Mouse", "refseq_name": "multicilin", "refseq_ac": [ { "id": "NP_001033003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033003", "type": "external" } ], "gene_names_uniprotkb": "Mcidas; Gm6320; Idas; Mcin; Mci", "gene_names_refseq": "EG622408; Gm6320; Idas; Mcidas; Mcin; Mci", "protein_names_uniprotkb": "Multicilin; McIdas protein; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas", "protein_names_refseq": "multiciliate cell differentiation; multicilin; protein Idas", "tax_id": 10090, "disease": "primary ciliary dyskinesia 42 (Disease Ontology:DOID:0111855)", "pathway": " (mmu:622408)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21543332;26395491;30877126", "class_list": "", "function": "GMNC protein induces Mci expression that drives the second step of basal body production for multiciliation Publication Status: Online-Only, [RefSeq, PubMed]; Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development., [RefSeq, PubMed]; Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche., [RefSeq, PubMed]; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UZ45-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R111-1", "uniprot_id": [ { "id": "GUAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R111", "type": "external" } ], "mass": 51013.0, "length": 454, "protein_name": "Guanine deaminase", "gene_name": "Gda", "organism": "Mouse", "refseq_name": "guanine deaminase", "refseq_ac": [ { "id": "NP_034396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034396", "type": "external" } ], "gene_names_uniprotkb": "Gda", "gene_names_refseq": "GAH; Gda", "protein_names_uniprotkb": "Guanine deaminase; 3.5.4.3; GAH; Guanase; Guanine aminase; Guanine aminohydrolase", "protein_names_refseq": "guanase; guanine aminase; guanine aminohydrolase; guanine deaminase", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:14544); (R-MMU-74259)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10075721;21750661;28011936;30084848;32848054;33300544;34428180;35822049;40684658;40885482", "class_list": "", "function": "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008892 guanine deaminase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0098794 postsynapse;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0046098 guanine metabolic process;GO:0031116 positive regulation of microtubule polymerization;GO:0006147 guanine catabolic process;GO:0006161 deoxyguanosine catabolic process;GO:0046038 GMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R111-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97378-1", "uniprot_id": [ { "id": "I12R2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97378", "type": "external" } ], "mass": 98197.0, "length": 874, "protein_name": "Interleukin-12 receptor subunit beta-2", "gene_name": "Il12rb2", "organism": "Mouse", "refseq_name": "interleukin-12 receptor subunit beta-2 isoform 2", "refseq_ac": [ { "id": "NP_001298070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298070", "type": "external" } ], "gene_names_uniprotkb": "Il12rb2", "gene_names_refseq": "A930027I18Rik; IL-12RB2; Ifnm; Il12rb2", "protein_names_uniprotkb": "Interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2", "protein_names_refseq": "IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interferon response to microorganisms; interleukin-12 receptor subunit beta-2 isoform 2; interleukin-12 receptor subunit beta-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16162); (R-MMU-8984722); (R-MMU-9020591)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11489994;12370372;21750661;35820727;8943050;9120387", "class_list": "", "function": "Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3., [UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "B9EHD9", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019901 protein kinase binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0042022 interleukin-12 receptor complex", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0051142 positive regulation of NK T cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97378-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31311-1", "uniprot_id": [ { "id": "HXA11_MOUSE", "url": "https://www.uniprot.org/uniprot/P31311", "type": "external" } ], "mass": 34484.0, "length": 313, "protein_name": "Homeobox protein Hox-A11", "gene_name": "Hoxa11", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A11", "refseq_ac": [ { "id": "NP_034580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034580", "type": "external" } ], "gene_names_uniprotkb": "Hoxa11; Hox-1.9; Hoxa-11", "gene_names_refseq": "Hox-1.9; Hoxa-11; Hoxa11", "protein_names_uniprotkb": "Homeobox protein Hox-A11; Homeobox protein Hox-1.9", "protein_names_refseq": "homeo box A11; homeobox protein Hox-1.9; homeobox protein Hox-A11", "tax_id": 10090, "disease": "radioulnar synostosis (Disease Ontology:DOID:9827)", "pathway": " (mmu:15396)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1683707;25428506;7596412;7789268", "class_list": "", "function": "Mice mutant for Hoxd11 and Hoxa11 show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 act together to specify limb outgrowth and patterning of proximodistal axis, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V026", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001759 organ induction;GO:0007501 mesodermal cell fate specification;GO:0010720 positive regulation of cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31311-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C886-1", "uniprot_id": [ { "id": "PKHN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C886", "type": "external" } ], "mass": 66826.0, "length": 610, "protein_name": "Probable pleckstrin homology domain-containing family N member 1", "gene_name": "Plekhn1", "organism": "Mouse", "refseq_name": "probable pleckstrin homology domain-containing family N member 1 isoform 2", "refseq_ac": [ { "id": "NP_001355568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355568", "type": "external" } ], "gene_names_uniprotkb": "Plekhn1; Clpabp", "gene_names_refseq": "Clpabp; Plekhn1", "protein_names_uniprotkb": "Probable pleckstrin homology domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein; PH domain-containing family N member 1", "protein_names_refseq": "PH domain-containing family N member 1; cardiolipin and phosphatidic acid-binding protein; probable pleckstrin homology domain-containing family N member 1 isoform 2; probable pleckstrin homology domain-containing family N member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231002)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27616329", "class_list": "", "function": "Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (PubMed:27616329). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1W2P6Q7;A0A1W2P7X5;Q8R3H1", "ec_number_list": [], "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0070300 phosphatidic acid binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C886-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARU5-1", "uniprot_id": [ { "id": "A2ARU5_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARU5", "type": "external" } ], "mass": 95461.0, "length": 834, "protein_name": "Zinc finger SCAN domains 29", "gene_name": "Zscan29", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 29 isoform a", "refseq_ac": [ { "id": "NP_001277748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277748", "type": "external" } ], "gene_names_uniprotkb": "Zscan29", "gene_names_refseq": "Zfp690; Zscan29", "protein_names_uniprotkb": "Zinc finger SCAN domains 29", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 29 isoform a; zinc finger protein 690", "tax_id": 10090, "disease": "", "pathway": " (mmu:99334)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2ARU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0J9YUD4-1", "uniprot_id": [ { "id": "A0A0J9YUD4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0J9YUD4", "type": "external" } ], "mass": 69715.0, "length": 600, "protein_name": "Zinc finger protein 433", "gene_name": "Zfp433", "organism": "Mouse", "refseq_name": "zinc finger protein 433 isoform 1", "refseq_ac": [ { "id": "NP_001229996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229996", "type": "external" } ], "gene_names_uniprotkb": "Zfp433; Zfp873", "gene_names_refseq": "1700123A16Rik; Zfp433", "protein_names_uniprotkb": "Zinc finger protein 433", "protein_names_refseq": "zinc finger protein 433 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73610)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0J9YUD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2E2-1", "uniprot_id": [ { "id": "MBD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2E2", "type": "external" } ], "mass": 70023.0, "length": 636, "protein_name": "Methyl-CpG-binding domain protein 1", "gene_name": "Mbd1", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 1 isoform 1", "refseq_ac": [ { "id": "NP_038622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038622", "type": "external" } ], "gene_names_uniprotkb": "Mbd1", "gene_names_refseq": "Cxxc3; Mbd1; PCM1", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1", "protein_names_refseq": "methyl-CpG-binding domain protein 1 isoform 1; methyl-CpG-binding protein MBD1", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:17190); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10441743;12697822;15060159;15777793;21750661;36574452;9774669", "class_list": "", "function": "Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMA4;Q3U101;Q6NSW0;Q792D6;Q8CCL9;Q9DC19", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0008327 methyl-CpG binding;GO:0045322 unmethylated CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation;GO:0048712 negative regulation of astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2E2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1SSC7-1", "uniprot_id": [ { "id": "A0A1L1SSC7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1L1SSC7", "type": "external" } ], "mass": 95090.0, "length": 844, "protein_name": "Tetratricopeptide repeat domain 13", "gene_name": "Ttc13", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 13 isoform 5 precursor", "refseq_ac": [ { "id": "NP_001360872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001360872", "type": "external" } ], "gene_names_uniprotkb": "Ttc13", "gene_names_refseq": "Ttc13", "protein_names_uniprotkb": "Tetratricopeptide repeat domain 13", "protein_names_refseq": "tetratricopeptide repeat protein 13 isoform 5 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:234875)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1L1SSC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VMD6-1", "uniprot_id": [ { "id": "A0A1Y7VMD6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMD6", "type": "external" } ], "mass": 55243.0, "length": 494, "protein_name": "Leucine rich repeat containing 74A", "gene_name": "Lrrc74a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrrc74a; Gm6772", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine rich repeat containing 74A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:627607)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VMD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5G0-1", "uniprot_id": [ { "id": "MK04_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5G0", "type": "external" } ], "mass": 65574.0, "length": 583, "protein_name": "Mitogen-activated protein kinase 4", "gene_name": "Mapk4", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 4 isoform 1", "refseq_ac": [ { "id": "NP_766220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766220", "type": "external" } ], "gene_names_uniprotkb": "Mapk4; Erk4; Prkm4", "gene_names_refseq": "A330097D03Rik; Erk3; Mapk4; Prkm4; p63Mapk", "protein_names_uniprotkb": "Mitogen-activated protein kinase 4; 2.7.11.24; ERK-4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAPK 4", "protein_names_refseq": "ERK-4; Erk3-related; MAP kinase 4; MAPK 4; extracellular signal-regulated kinase 4; mitogen-activated protein kinase 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225724); (R-MMU-5687128)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16973613;18248330;18720373;19473979;21183079;21750661;25002529;32139423;33125780;34428180", "class_list": "", "function": "Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle., [UniProtKB, PubMed]; C/EBPalpha/miR-7 Controls CD4(+) T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice., [RefSeq, PubMed]; Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3., [RefSeq, PubMed]; Results uncover a unique role for ERK3, dependent on its kinase activity, during T cell development and show that this atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes survival during RAG-mediated rearrangements., [RefSeq, PubMed]; Targeted deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation, promoting lean phenotype and ameliorating diabetes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0060020 Bergmann glial cell differentiation;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P5G0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P7S4-1", "uniprot_id": [ { "id": "A0A1W2P7S4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P7S4", "type": "external" } ], "mass": 49384.0, "length": 437, "protein_name": "TLE family member 7", "gene_name": "Tle7", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001423152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423152", "type": "external" } ], "gene_names_uniprotkb": "Tle7; Gm21964", "gene_names_refseq": "Gm21964; Tle7", "protein_names_uniprotkb": "TLE family member 7", "protein_names_refseq": "transducin-like enhancer protein 7 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102638837)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P7S4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMZ3-1", "uniprot_id": [ { "id": "PLPP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMZ3", "type": "external" } ], "mass": 29223.0, "length": 260, "protein_name": "Phospholipid phosphatase 5", "gene_name": "Plpp5", "organism": "Mouse", "refseq_name": "phospholipid phosphatase 5 isoform 1", "refseq_ac": [ { "id": "NP_082276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082276", "type": "external" } ], "gene_names_uniprotkb": "Plpp5; Ppapdc1b", "gene_names_refseq": "1810019D05Rik; 2310022A04Rik; Plpp5; Ppapdc1b; Ppapdc1", "protein_names_uniprotkb": "Phospholipid phosphatase 5; 3.1.3.4; 3.6.1.75", "protein_names_refseq": "phosphatidate phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2 domain containing 1B; phosphatidic acid phosphatase type 2 domain containing 1; phosphatidic acid phosphatase type 2 domain-containing protein 1B; phospholipid phosphatase 5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71910); (R-MMU-2029485)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KL19", "ec_number_list": [ { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UMZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSF4-1", "uniprot_id": [ { "id": "PISD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSF4", "type": "external" } ], "mass": 45927.0, "length": 406, "protein_name": "Phosphatidylserine decarboxylase proenzyme, mitochondrial", "gene_name": "Pisd", "organism": "Mouse", "refseq_name": "phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_796272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796272", "type": "external" } ], "gene_names_uniprotkb": "Pisd; PISD", "gene_names_refseq": "9030221M09Rik; Pisd", "protein_names_uniprotkb": "Phosphatidylserine decarboxylase proenzyme, mitochondrial; 4.1.1.65", "protein_names_refseq": "phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1; phosphatidylserine decarboxylase proenzyme, mitochondrial", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:320951)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16192276;21750661;31219806;31285171;34428180;6862014", "class_list": "", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphatidylserine decarboxylase in mice is required for embryonic survival and mitochondria, [RefSeq, PubMed]; The phosphatidylserine decarboxylase pathway has a significant role in maintaining phospholipid homeostasis in adult skeletal muscle. Moreover, phosphatidylserine decarboxylase is essential for maintenance of mitochondrial integrity and skeletal muscle mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSD6", "ec_number_list": [ { "id": "4.1.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.65", "type": "external" } ], "go_molecular_function": "GO:0004609 phosphatidylserine decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0016540 protein autoprocessing;GO:0035694 mitochondrial protein catabolic process;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0010821 regulation of mitochondrion organization;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BSF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG1-1", "uniprot_id": [ { "id": "PIGP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHG1", "type": "external" } ], "mass": 15101.0, "length": 132, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit P", "gene_name": "Pigp", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform a", "refseq_ac": [ { "id": "NP_001153088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153088", "type": "external" } ], "gene_names_uniprotkb": "Pigp; Dcrc; Dscr5", "gene_names_refseq": "Dcrc; Dscr5; Pigp", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Down syndrome critical region protein 5 homolog; PIG-P; Phosphatidylinositol-glycan biosynthesis class P protein", "protein_names_refseq": "Down syndrome critical region gene c; Down syndrome critical region homolog 5; PIG-P; down syndrome critical region protein 5 homolog; phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform a; phosphatidylinositol N-acetylglucosaminyltransferase subunit P; phosphatidylinositol-glycan biosynthesis class P protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 55 (Disease Ontology:DOID:0080283)", "pathway": " (mmu:56176); (R-MMU-162710)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11331941;21750661;25428506", "class_list": "glycogene;glycosyltransferase", "function": "Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., [UniProtKB, UniProtKB]; Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JHG1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAK2-1", "uniprot_id": [ { "id": "PACRG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAK2", "type": "external" } ], "mass": 27726.0, "length": 241, "protein_name": "Parkin coregulated gene protein homolog", "gene_name": "Pacrg", "organism": "Mouse", "refseq_name": "parkin coregulated gene protein homolog", "refseq_ac": [ { "id": "NP_081308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081308", "type": "external" } ], "gene_names_uniprotkb": "Pacrg", "gene_names_refseq": "1700008H23Rik; Pacrg", "protein_names_uniprotkb": "Parkin coregulated gene protein homolog; Hypertension-related protein 1-like protein; PARK2 coregulated gene protein", "protein_names_refseq": "PARK2 coregulated gene protein; hypertension-related protein 1-like protein; parkin co-regulated gene protein; parkin coregulated gene protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69310)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12547187;14743368;15148410;19805151;29760428;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin) (By similarity). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PACRG is linked to parkin via a bi-directional promoter [PACRG], [RefSeq, PubMed]; Results demonstrate that the deletion of Pacrg (PARKIN-coregulated gene) is the cause of male sterility in the Quaking(viable) (qk(v)) mutant mouse., [RefSeq, PubMed]; Results show that aged single knockout Pacrg mouse and double knockout parkin-Pacrg mouse do not show behavioral or neuropathological deficits of the dopaminergic system. Collectively, these studies suggest that gene mediated deficiency in the mouse may alter pathways common to human pathogenesis but for as yet unknown reasons do not cause a pronounced Parkinson disease-like phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; The quaking mutation is a deletion of approximately 1.17 Mb of mouse chromosome 17, resulting in the deletion of the entire promoter and first five coding exons of PRKN. The recently described Parkin Co-Regulated Gene (PACRG) is completely deleted., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPF9;Q8CG20", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051087 protein-folding chaperone binding;GO:0001664 G protein-coupled receptor binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0008104 intracellular protein localization;GO:0034620 cellular response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DAK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2EG98-8", "uniprot_id": [ { "id": "PK1L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2EG98", "type": "external" } ], "mass": 236389.0, "length": 2151, "protein_name": "Polycystin-1-like protein 3", "gene_name": "Pkd1l3", "organism": "Mouse", "refseq_name": "polycystin-1-like protein 3 isoform a", "refseq_ac": [ { "id": "NP_001034789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034789", "type": "external" } ], "gene_names_uniprotkb": "Pkd1l3; 71B10", "gene_names_refseq": "Pkd1l3", "protein_names_uniprotkb": "Polycystin-1-like protein 3; PC1-like 3 protein; Polycystic kidney disease protein 1-like 3; Polycystin-1L3", "protein_names_refseq": "PC1-like 3 protein; polycystic kidney disease protein 1-like 3; polycystin-1-like protein 3 isoform a; polycystin-1-like protein 3; polycystin-1L3", "tax_id": 10090, "disease": "autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:244646)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12782129;16805797;16891422;16929298;18535624;19464260;20406802;20538909;20605874;21098668;21185261;21625513;22420714;30928102;34381056", "class_list": "", "function": "Genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores Erratum:[Genomics. 2003 Oct;82(4):498-500], [RefSeq, PubMed]; PKD1L3 is cleaved at the N-terminal G protein-coupled receptor proteolytic site.Leucine-708 and Serine-709 are crucial for G protein-coupled receptor proteolytic site cleavage in mouse PKD1L3. Erratum:[Biochem Biophys Res Commun. 2019 Jun 25;514(2):565. doi: 10.1016/j.bbrc.2019.04.150. PMID: 31056259], [RefSeq, PubMed]; PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1., [RefSeq, PubMed]; Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer, [RefSeq, PubMed]; Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:16891422, PubMed:18535624, PubMed:20406802, PubMed:21185261, PubMed:22420714, PubMed:34381056). Also shows permeability towards NA(1+), K(+) and Mg(2+) (PubMed:18535624, PubMed:34381056). Heterotetrameric complex channel is activated by external low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:16891422, PubMed:16929298, PubMed:18535624, PubMed:20406802, PubMed:34381056). May act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:16891422, PubMed:21098668, PubMed:21625513)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation., [RefSeq, PubMed]; These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QPA5;Q2EG93;Q2EG94;Q2EG95;Q2EG96;Q2EG97;Q2EG99;Q7TN87", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005227 calcium-activated cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport;GO:0070588 calcium ion transmembrane transport;GO:0050915 sensory perception of sour taste;GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q2EG98-8", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UM45-1", "uniprot_id": [ { "id": "PP1R7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UM45", "type": "external" } ], "mass": 41292.0, "length": 361, "protein_name": "Protein phosphatase 1 regulatory subunit 7", "gene_name": "Ppp1r7", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 7", "refseq_ac": [ { "id": "NP_075689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075689", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r7; Sds22", "gene_names_refseq": "2310014J01Rik; Ppp1r7; SDS22", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 7; Protein phosphatase 1 regulatory subunit 22", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 22; protein phosphatase 1 regulatory subunit 7; protein phosphatase 1, regulatory (inhibitor) subunit 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66385)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10231361;12972598;18299400;19224205;20173027;20484733;21183079;21750661;21952136;25428506;25605945;29669786;30084848;30144392;30779550;34203471;34428180;35820727;35984892;37507081", "class_list": "", "function": "Ppp1r7 may play a central role in regulating the PP1 interactome by acting as a competitive molecular 'sponge' of PP1c during heart failure progression., [RefSeq, PubMed]; Regulatory subunit of protein phosphatase 1., [UniProtKB]; The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV31;Q9Z105", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q3UM45-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8L4-1", "uniprot_id": [ { "id": "A0A140T8L4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140T8L4", "type": "external" } ], "mass": 36058.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or52z15", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or52z15; Olfr625", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140T8L4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3I2-1", "uniprot_id": [ { "id": "MBOA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3I2", "type": "external" } ], "mass": 58995.0, "length": 519, "protein_name": "Membrane-bound glycerophospholipid O-acyltransferase 2", "gene_name": "Mboat2", "organism": "Mouse", "refseq_name": "membrane-bound glycerophospholipid O-acyltransferase 2 isoform b", "refseq_ac": [ { "id": "NP_001076810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076810", "type": "external" } ], "gene_names_uniprotkb": "Mboat2; Lpcat4; Oact2", "gene_names_refseq": "2810049G06Rik; LPCAT4; Mboat2; Moact2; Oact2", "protein_names_uniprotkb": "Membrane-bound glycerophospholipid O-acyltransferase 2; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n7; LPCAT; LPEAT; LPLAT 2; Lyso-PC acyltransferase 4; Lyso-PC acyltransferase; Lyso-PE acyltransferase; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylcholine acyltransferase; Lysophosphatidylethanolamine acyltransferase; Lysophospholipid acyltransferase 2; Membrane-bound O-acyltransferase domain-containing protein 2; O-acyltransferase domain-containing protein 2; mLPCAT4", "protein_names_refseq": "1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; LPC acyltransferase 4; LPCAT; LPEAT; LPLAT 2; O-acyltransferase (membrane bound) domain containing 2; O-acyltransferase domain-containing protein 2; lyso-PC acyltransferase 4; lyso-PE acyltransferase; lysophosphatidylcholine acyltransferase 4; lysophosphatidylethanolamine acyltransferase; lysophospholipid acyltransferase 2; mLPCAT4; membrane-bound O-acyltransferase domain-containing protein 2; membrane-bound glycerophospholipid O-acyltransferase 2 isoform b; membrane-bound glycerophospholipid O-acyltransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67216); (R-MMU-1482788); (R-MMU-1482839)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17890783;18287005;21750661;29196633", "class_list": "", "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18287005, PubMed:29196633). Catalyzes the acylation of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) and to a lesser extend lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) (PubMed:18287005, PubMed:29196633). Does not acylates lysophosphatidic acid (LPA) and lysophosphatidylserine (PubMed:18287005). Prefers oleoyl-CoA as the acyl donor (PubMed:18287005, PubMed:29196633). May be involved in chondrocyte differentiation (PubMed:29196633)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9EDS7;Q8BHH5;Q8BM56;Q8R192;Q9CZ73", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0032330 regulation of chondrocyte differentiation;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R3I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7A8-1", "uniprot_id": [ { "id": "D3Z7A8_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z7A8", "type": "external" } ], "mass": 87175.0, "length": 784, "protein_name": "WD40 repeat domain 95", "gene_name": "Wdr95", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr95", "gene_names_refseq": "", "protein_names_uniprotkb": "WD40 repeat domain 95", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:381693)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z7A8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D306-1", "uniprot_id": [ { "id": "MGT4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D306", "type": "external" } ], "mass": 56250.0, "length": 478, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C", "gene_name": "Mgat4c", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C", "refseq_ac": [ { "id": "NP_001155840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155840", "type": "external" } ], "gene_names_uniprotkb": "Mgat4c", "gene_names_refseq": "9130411I17Rik; GntIVh; Mgat4c", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; 2.4.1.145; GnT-IVc; N-acetylglucosaminyltransferase IVc; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc", "protein_names_refseq": "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; gnT-IVc; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)", "tax_id": 10090, "disease": "", "pathway": " (mmu:67569); (R-MMU-975577)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20173027;21750661;27802388;28011936;30084848", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2X2", "ec_number_list": [ { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 3884, "hit_score": 0.6, "record_id": "Q9D306-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBH5-1", "uniprot_id": [ { "id": "MFSD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBH5", "type": "external" } ], "mass": 86076.0, "length": 775, "protein_name": "Major facilitator superfamily domain-containing protein 6", "gene_name": "Mfsd6", "organism": "Mouse", "refseq_name": "major facilitator superfamily domain-containing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_835182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835182", "type": "external" } ], "gene_names_uniprotkb": "Mfsd6; Mmr2", "gene_names_refseq": "2210010L05Rik; 9630025I22Rik; MMR2; Mfsd6", "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 6; Macrophage MHC class I receptor 2", "protein_names_refseq": "macrophage MHC class I receptor 2; macrophage MHC receptor 2; major facilitator superfamily domain-containing protein 6 isoform 2; major facilitator superfamily domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:98682)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17010536;19144319;21183079;21750661;23836286;31906755;34428180", "class_list": "", "function": "Isolation of a cDNA clone encoding a novel receptor (MMR2) on allograft (H-2D(d)K(d))-induced macrophages (AIM) recognizing another MHC class I molecule, H-2K(d), by the expression cloning method, [RefSeq, PubMed]; MHC class I receptor. Binds only to H-2 class I histocompatibility antigen, K-D alpha chain (H-2K(D))., [UniProtKB, PubMed]; MMRs on monocytes/macrophages and TCRs on cytotoxic T lymphocytes in mice were essential for recognition and rejection of allografted skin and lymphoma, respectively., [RefSeq, PubMed]; Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8K4;Q8VIG4", "ec_number_list": [], "go_molecular_function": "GO:0042288 MHC class I protein binding;GO:0032393 MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CBH5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YFS1-1", "uniprot_id": [ { "id": "PILB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2YFS1", "type": "external" } ], "mass": 25513.0, "length": 225, "protein_name": "Paired immunoglobulin-like type 2 receptor beta-2", "gene_name": "Pilrb2", "organism": "Mouse", "refseq_name": "paired immunoglobulin-like type 2 receptor beta-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001020103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020103", "type": "external" } ], "gene_names_uniprotkb": "Pilrb2", "gene_names_refseq": "EG545812; Pilrb2", "protein_names_uniprotkb": "Paired immunoglobulin-like type 2 receptor beta-2; Activating receptor PILR-beta-2", "protein_names_refseq": "activating receptor PILR-beta-2; paired immunoglobulin-like type 2 receptor beta-2 isoform 1 precursor; paired immunoglobulin-like type 2 receptor beta-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:545812)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB2 is probably a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2YFS1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80SX8-1", "uniprot_id": [ { "id": "PIF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80SX8", "type": "external" } ], "mass": 70942.0, "length": 650, "protein_name": "ATP-dependent DNA helicase PIF1", "gene_name": "Pif1", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase PIF1 isoform 1", "refseq_ac": [ { "id": "NP_766041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766041", "type": "external" } ], "gene_names_uniprotkb": "Pif1; PIF1", "gene_names_refseq": "4631410M14; Pif1", "protein_names_uniprotkb": "ATP-dependent DNA helicase PIF1; 5.6.2.3; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; Pif1/Rrm3 DNA helicase-like protein", "protein_names_refseq": "ATP-dependent DNA helicase PIF1 isoform 1; ATP-dependent DNA helicase PIF1; DNA 5'-3' helicase PIF1; DNA helicase-like protein; DNA repair and recombination helicase PIF1; PIF1 5'-to-3' DNA helicase homolog; PIF1 homolog; Pif1/Rrm3 DNA helicase-like protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); progeria (Disease Ontology:DOID:3911)", "pathway": " (mmu:208084); (R-MMU-171319)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17130244;21750661;21945094;23275553;26923168;31136580;35820727", "class_list": "", "function": "DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity., [UniProtKB, HAMAP, UniProtKB]; Murine cells have evolved mechanisms to ensure the functional redundancy of Pif1 or Nbs1 in the regulation of chromosome healing., [RefSeq, PubMed]; Murine telomere homeostasis or genetic stability does not depend on mPif1., [RefSeq, PubMed]; Pif1-/- animals develop a mitochondrial myopathy with respiratory chain deficiency., [RefSeq, PubMed]; They also support a role for Pif1 in weight gain resistance and liver metabolic dysregulation during nutrient stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80W44;Q8BIZ3;Q8BJ72", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0001117 protein-DNA-RNA complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80SX8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YWQ9-1", "uniprot_id": [ { "id": "TM196_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YWQ9", "type": "external" } ], "mass": 18896.0, "length": 176, "protein_name": "Transmembrane protein 196", "gene_name": "Tmem196", "organism": "Mouse", "refseq_name": "transmembrane protein 196 isoform 2", "refseq_ac": [ { "id": "NP_001153857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153857", "type": "external" } ], "gene_names_uniprotkb": "Tmem196", "gene_names_refseq": "Gm528; Tmem196", "protein_names_uniprotkb": "Transmembrane protein 196", "protein_names_refseq": "transmembrane protein 196 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217951)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26056045;36355209", "class_list": "", "function": "Acts as a tumor suppressor in lung cancer (PubMed:26056045, PubMed:36355209). Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis (By similarity). Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway (PubMed:36355209)., [UniProtKB, PubMed, UniProtKB, PubMed]; TMEM196 inhibits lung cancer metastasis by regulating the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030336 negative regulation of cell migration;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YWQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YXJ0-1", "uniprot_id": [ { "id": "DGKH_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YXJ0", "type": "external" } ], "mass": 134132.0, "length": 1211, "protein_name": "Diacylglycerol kinase eta", "gene_name": "Dgkh", "organism": "Mouse", "refseq_name": "diacylglycerol kinase eta isoform 1", "refseq_ac": [ { "id": "NP_001074805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074805", "type": "external" } ], "gene_names_uniprotkb": "Dgkh", "gene_names_refseq": "5930402B05Rik; D130015C16; DGK; Dgkh", "protein_names_uniprotkb": "Diacylglycerol kinase eta; 2.7.1.107; DAG kinase eta; DGK-eta; Diglyceride kinase eta", "protein_names_refseq": "DAG kinase eta; DGK-eta; diacylglycerol kinase eta isoform 1; diglyceride kinase eta", "tax_id": 10090, "disease": "", "pathway": " (mmu:380921); (R-MMU-114508)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;22645316;25613821;27643686;32791090;33599293;35248948", "class_list": "", "function": "Diacylglycerol kinase eta regulates C2C12 myoblast proliferation through the mTOR signaling pathway., [RefSeq, PubMed]; Diacylglycerol kinase eta regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity)., [UniProtKB, PubMed, UniProtKB]; Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase eta-knockout mouse brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B5JC35", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0032093 SAM domain binding;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D3YXJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH93-1", "uniprot_id": [ { "id": "MISSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH93", "type": "external" } ], "mass": 23885.0, "length": 242, "protein_name": "MAPK-interacting and spindle-stabilizing protein-like", "gene_name": "Mapk1ip1l", "organism": "Mouse", "refseq_name": "MAPK-interacting and spindle-stabilizing protein-like isoform 1", "refseq_ac": [ { "id": "NP_848799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848799", "type": "external" } ], "gene_names_uniprotkb": "Mapk1ip1l", "gene_names_refseq": "9130202B12; C130032J12Rik; Mapk1ip1l", "protein_names_uniprotkb": "MAPK-interacting and spindle-stabilizing protein-like; Mitogen-activated protein kinase 1-interacting protein 1-like", "protein_names_refseq": "MAPK-interacting and spindle-stabilizing protein-like isoform 1; MAPK-interacting and spindle-stabilizing protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:218975)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;28528544;31219806;32782141;36852467", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF12;Q3TGL0;Q8CC90", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BH93-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60954-1", "uniprot_id": [ { "id": "MEIS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60954", "type": "external" } ], "mass": 43002.0, "length": 390, "protein_name": "Homeobox protein Meis1", "gene_name": "Meis1", "organism": "Mouse", "refseq_name": "homeobox protein Meis1 isoform B", "refseq_ac": [ { "id": "NP_001180200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180200", "type": "external" } ], "gene_names_uniprotkb": "Meis1", "gene_names_refseq": "C530044H18Rik; Evi8; Meis1", "protein_names_uniprotkb": "Homeobox protein Meis1; Myeloid ecotropic viral integration site 1", "protein_names_refseq": "homeobox protein Meis1 isoform B; homeobox protein Meis1; myeloid ecotropic viral integration site 1", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); heart disease (Disease Ontology:DOID:114); leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:17268)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10082572;10523646;12183364;15654074;15882575;21059917;21750661;7565694;9315626;9525891", "class_list": "", "function": "Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARH5;Q5SVC8;Q60955;Q8CIL0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007626 locomotory behavior;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60954-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76LS9-1", "uniprot_id": [ { "id": "MINY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q76LS9", "type": "external" } ], "mass": 51226.0, "length": 468, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "Mindy1", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2", "refseq_ac": [ { "id": "NP_598619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598619", "type": "external" } ], "gene_names_uniprotkb": "Mindy1; Fam63a; Ni", "gene_names_refseq": "1810005H09Rik; 4930504E06Rik; Fam63a; Mindy1; cI-40; mKIAA1390; ni", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-1; 3.4.19.12; Deubiquitinating enzyme MINDY-1; NF-E2 inducible protein; Protein FAM63A", "protein_names_refseq": "NF-E2 inducible protein; deubiquitinating enzyme MINDY-1; family with sequence similarity 63, member A; protein FAM63A; ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2; ubiquitin carboxyl-terminal hydrolase MINDY-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75007)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;17923245;18299400;19144319;21183079;21750661;21952136;25605945;29644784;30084848;31219806;34203471;34428180;36210013", "class_list": "", "function": "Early megakaryocyte differentiation, characterized by colony-forming unit MK formation, was enhanced by p45-NF-E2 overexpression at the expense of CFU-granulocyte macrophage development. An increased number of acetylcholinesterase(+) MKs was observed., [RefSeq, PubMed]; High polyamine levels are required for embryonic stem cells self-renewal and that they function, in part, through promotion of high MINDY1 levels., [RefSeq, PubMed]; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEF4;Q52KE4;Q566I9;Q6PES4;Q80V14;Q8CB41;Q8CHR2", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0016807 cysteine-type carboxypeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q76LS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TRM4-1", "uniprot_id": [ { "id": "PLPL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TRM4", "type": "external" } ], "mass": 149537.0, "length": 1355, "protein_name": "Patatin-like phospholipase domain-containing protein 6", "gene_name": "Pnpla6", "organism": "Mouse", "refseq_name": "patatin-like phospholipase domain-containing protein 6 isoform 1", "refseq_ac": [ { "id": "NP_001116290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116290", "type": "external" } ], "gene_names_uniprotkb": "Pnpla6; Nte", "gene_names_refseq": "MSws; Nte; Pnpla6", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 6; 3.1.1.5; Neuropathy target esterase", "protein_names_refseq": "Swiss-cheese; neuropathy target esterase; patatin-like phospholipase domain-containing protein 6 isoform 1; patatin-like phospholipase domain-containing protein 6", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:50767); (R-MMU-6814848)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10640712;12640454;12805562;16963094;18086666;20112100;21750661;22645316;30084848;30899004;31219806;34428180;37828378;38735647", "class_list": "", "function": "Mouse brain neuropathy target esterase is a lysophospholipase, [RefSeq, PubMed]; NTE has a role in neural development and in the neurodegeneration induced by organophosphate compounds in mice, [RefSeq, PubMed]; Neuropathy target esterase activity defines phenotypes among PNPLA6 disorders., [RefSeq, PubMed]; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho) (Probable) (PubMed:18086666). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The expression of CaMKIIalpha and pCREB exhibits a significant increase in cortex and hippocampus after treatment with PFOS, compared with the control., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQD6;Q9R114", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" } ], "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0102545 phospholipase B activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0016042 lipid catabolic process;GO:0009887 animal organ morphogenesis;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3TRM4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35904-1", "uniprot_id": [ { "id": "PK3CD_MOUSE", "url": "https://www.uniprot.org/uniprot/O35904", "type": "external" } ], "mass": 119712.0, "length": 1043, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform", "gene_name": "Pik3cd", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a", "refseq_ac": [ { "id": "NP_001157524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157524", "type": "external" } ], "gene_names_uniprotkb": "Pik3cd", "gene_names_refseq": "2410099E07Rik; 2610208K16Rik; Pik3cd; p110delta", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; 2.7.1.137; 2.7.1.153; PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta", "protein_names_refseq": "PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; catalytic phosphatidylinositol 3-kinase delta; p100 delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a; phosphoinositide 3 kinase P110delta; ptdIns-3-kinase subunit delta; ptdIns-3-kinase subunit p110-delta", "tax_id": 10090, "disease": "immunodeficiency 14 (Disease Ontology:DOID:0111936); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18707); (R-MMU-1257604); (R-MMU-1660499); (R-MMU-389357); (R-MMU-512988); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-9027276); (R-MMU-912526); (R-MMU-912631); (R-MMU-983695); (R-MMU-9927354)", "pathway_count": 12, "publication_count": 17, "publication_id_list": "12130661;12235209;12774123;15496927;16116162;18259608;18809712;19297623;20081827;21750661;22020336;31219806;34428180;38365134;38705383;38829130;9235916", "class_list": "", "function": "A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular Proliferation., [RefSeq, PubMed]; Activated PI3Kdelta Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation., [RefSeq, PubMed]; PI3Kdelta inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-alpha dependent manner., [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:9235916). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJ28", "ec_number_list": [ { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35904-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2R1-1", "uniprot_id": [ { "id": "POMT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2R1", "type": "external" } ], "mass": 85234.0, "length": 746, "protein_name": "Protein O-mannosyl-transferase 1", "gene_name": "Pomt1", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase 1 isoform 1", "refseq_ac": [ { "id": "NP_660127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660127", "type": "external" } ], "gene_names_uniprotkb": "Pomt1", "gene_names_refseq": "Pomt1", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 1; 2.4.1.109; Dolichyl-phosphate-mannose--protein mannosyltransferase 1", "protein_names_refseq": "dolichyl-phosphate-mannose--protein mannosyltransferase 1; protein O-mannosyl-transferase 1 isoform 1; protein O-mannosyl-transferase 1", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2K (Disease Ontology:DOID:0110297); congenital muscular dystrophy-dystroglycanopathy type A1 (Disease Ontology:DOID:0111237); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:99011); (R-MMU-8932504); (R-MMU-8932505); (R-MMU-8932506); (R-MMU-9768727)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15383666;21750661;29867208;30899004;31219806;34428180;35820727", "class_list": "glycogene;glycosyltransferase", "function": "-mannosylation of alpha-DG in the retina carried out by POMT1 is crucial for the establishment of proper synapses at the OPL and transmission of visual information from cones and rods to their postsynaptic neurons. Publication Status: Online-Only, [RefSeq, PubMed]; During embryogenesis, Pomt1 is expressed in the neural tube, the developing eye, and the mesenchyme; targeted deletion of Pomt1 results in early embryonic lethality due to defects in the assembly of Reichert's membrane, [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYD8;Q64J18;Q8BPJ6;Q8BPU1;Q8R474", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle;GO:0016529 sarcoplasmic reticulum;GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex", "go_biological_process": "GO:1904100 positive regulation of protein O-linked glycosylation;GO:0030198 extracellular matrix organization;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 1677, "hit_score": 1.5, "record_id": "Q8R2R1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YFS3-1", "uniprot_id": [ { "id": "PILRA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2YFS3", "type": "external" } ], "mass": 33064.0, "length": 302, "protein_name": "Paired immunoglobulin-like type 2 receptor alpha", "gene_name": "Pilra", "organism": "Mouse", "refseq_name": "paired immunoglobulin-like type 2 receptor alpha precursor", "refseq_ac": [ { "id": "NP_705730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705730", "type": "external" } ], "gene_names_uniprotkb": "Pilra", "gene_names_refseq": "FDF03; Pilra", "protein_names_uniprotkb": "Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha", "protein_names_refseq": "cell surface receptor FDF03; inhibitory receptor PILR-alpha; paired immunoglobulin-like type 2 receptor alpha precursor; paired immunoglobulin-like type 2 receptor alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:231805); (R-MMU-198933)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10903717;14970179;20065029;20573830;21241660;21750661;27349870;31385804;35617401", "class_list": "", "function": "Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response., [RefSeq, PubMed]; Domain V of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion., [RefSeq, PubMed]; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. Receptor for CD99 and PIANP., [UniProtKB, PubMed]; The CD8alpha-PILRalpha interaction maintains CD8(+) T cell quiescence., [RefSeq, PubMed]; Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase., [RefSeq, PubMed]; Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYA6", "ec_number_list": [], "go_molecular_function": "GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q2YFS3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYP2-1", "uniprot_id": [ { "id": "E9PYP2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYP2", "type": "external" } ], "mass": 306178.0, "length": 2688, "protein_name": "Neurobeachin like 1", "gene_name": "Nbeal1", "organism": "Mouse", "refseq_name": "neurobeachin-like protein 1", "refseq_ac": [ { "id": "NP_775620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775620", "type": "external" } ], "gene_names_uniprotkb": "Nbeal1", "gene_names_refseq": "2310076G13Rik; A530050O19Rik; A530083I02Rik; ALS2CR17; Nbeal1", "protein_names_uniprotkb": "Neurobeachin like 1", "protein_names_refseq": "neurobeachin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269198)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30779550;31599954", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PYP2-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1B7-1", "uniprot_id": [ { "id": "MK13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1B7", "type": "external" } ], "mass": 42072.0, "length": 366, "protein_name": "Mitogen-activated protein kinase 13", "gene_name": "Mapk13", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 13", "refseq_ac": [ { "id": "NP_036080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036080", "type": "external" } ], "gene_names_uniprotkb": "Mapk13; Serk4", "gene_names_refseq": "Mapk13; SAPK4; Serk4", "protein_names_uniprotkb": "Mitogen-activated protein kinase 13; 2.7.11.24; MAP kinase 13; MAP kinase p38 delta; MAPK 13; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4", "protein_names_refseq": "MAP kinase 13; MAP kinase p38 delta; MAPK 13; SAPK/Erk/kinase 4; mitogen-activated protein kinase 13; mitogen-activated protein kinase p38 delta; p38 delta MAP kinase; stress-activated protein kinase 4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:26415); (R-MMU-168638); (R-MMU-4420097)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11378392;11846446;19135240;20090411;20626350;21183079;21558321;21750661;37458356", "class_list": "", "function": "Overexpression of the type II transforming growth factor-beta receptor inhibits fibroblasts proliferation and activates extracellular signal regulated kinase and c-Jun N-terminal kinase, [RefSeq, PubMed]; P38gamma and p38delta modulate innate immune response by regulating MEF2D activation. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M57", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity;GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072709 cellular response to sorbitol;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0006970 response to osmotic stress;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z1B7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q711-1", "uniprot_id": [ { "id": "E9Q711_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q711", "type": "external" } ], "mass": 83002.0, "length": 769, "protein_name": "Low-density lipoprotein receptor-related protein 3", "gene_name": "Lrp3", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001408463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001408463", "type": "external" } ], "gene_names_uniprotkb": "Lrp3", "gene_names_refseq": "Lrp3", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 3; 105 kDa low-density lipoprotein receptor-related protein", "protein_names_refseq": "low-density lipoprotein receptor-related protein 3 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:435965)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;36414669", "class_list": "", "function": "Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4. Publication Status: Online-Only, [RefSeq, PubMed]; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005905 clathrin-coated pit;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045669 positive regulation of osteoblast differentiation;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q711-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPQ2-1", "uniprot_id": [ { "id": "ARI4A_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPQ2", "type": "external" } ], "mass": 142055.0, "length": 1261, "protein_name": "AT-rich interactive domain-containing protein 4A", "gene_name": "Arid4a", "organism": "Mouse", "refseq_name": "AT-rich interactive domain-containing protein 4A", "refseq_ac": [ { "id": "NP_001074664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074664", "type": "external" } ], "gene_names_uniprotkb": "Arid4a; Rbbp1; Rbp1", "gene_names_refseq": "A630009N03; A630067N03Rik; Arid4a; Rbbp1", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 4A; ARID domain-containing protein 4A; Retinoblastoma-binding protein 1", "protein_names_refseq": "ARID domain-containing protein 4A; AT rich interactive domain 4A (RBP1-like); AT rich interactive domain 4A (Rbp1 like); AT-rich interactive domain-containing protein 4A; retinoblastoma-binding protein 1", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:238247); (R-MMU-3214815)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14581478;15750587;15922553;17043311;18728284;21750661;23487765;34428180", "class_list": "", "function": "DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (PubMed:17043311, PubMed:23487765). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity (PubMed:23487765). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (PubMed:17043311). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation (PubMed:23487765). Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis (PubMed:18728284). May function as a leukemia suppressor (PubMed:18728284)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; RBP1 and the mSin3 histone deacetylase complex bind to BRMS1 and repress transcription, [RefSeq, PubMed]; The retinoblastoma binding protein 1 shows a marked genomic instability, which is coincidental with decreased DNA methylation, increased acetylation of histone H3 and decreased tri-methylation of histone H4 at lysine 20 (H4K20)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXT8;B2RY61;Q05CI2;Q6PE90", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0017053 transcription repressor complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F8VPQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERV7-1", "uniprot_id": [ { "id": "PIDD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERV7", "type": "external" } ], "mass": 101141.0, "length": 915, "protein_name": "p53-induced death domain-containing protein 1", "gene_name": "Pidd1", "organism": "Mouse", "refseq_name": "p53-induced death domain-containing protein 1 isoform a", "refseq_ac": [ { "id": "NP_073145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073145", "type": "external" } ], "gene_names_uniprotkb": "Pidd1; Lrdd; Pidd", "gene_names_refseq": "1200011D09Rik; Lrdd; Pidd1; Pidd", "protein_names_uniprotkb": "p53-induced death domain-containing protein 1; 3.4.21.-; Leucine-rich repeat and death domain-containing protein", "protein_names_refseq": "leucine-rich and death domain containing; leucine-rich repeat and death domain-containing protein; p53 protein induced, with death domain; p53-induced death domain-containing protein 1 isoform a; p53-induced death domain-containing protein 1; p53-induced protein with a death domain", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 75 (Disease Ontology:DOID:0081234)", "pathway": " (mmu:57913); (R-MMU-6803207)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10973264;11695552;19364921;21750661;21952136;22279524;31219806;34428180", "class_list": "", "function": "Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity)., [UniProtKB, UniProtKB, PubMed]; P450 levels were higher in female DES-treated p53+/- mice compared to treated wild type mice. Review article, [RefSeq, PubMed]; Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 activation exists in mammals in response to DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6F4", "ec_number_list": [ { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ERV7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q271-1", "uniprot_id": [ { "id": "E9Q271_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q271", "type": "external" } ], "mass": 147423.0, "length": 1322, "protein_name": "WD repeat domain 17", "gene_name": "Wdr17", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr17", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain 17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q271-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KWH5-1", "uniprot_id": [ { "id": "PLCH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KWH5", "type": "external" } ], "mass": 187743.0, "length": 1682, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1", "gene_name": "Plch1", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3", "refseq_ac": [ { "id": "NP_001171203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171203", "type": "external" } ], "gene_names_uniprotkb": "Plch1; Kiaa1069; Plcl3", "gene_names_refseq": "PLC-eta-1; PLCeta1; Plch1; Plcl3", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; 3.1.4.11; PLC-L3; PLC-eta-1; Phosphoinositide phospholipase C-eta-1; Phospholipase C-eta-1; Phospholipase C-like protein 3", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; phosphoinositide phospholipase C-eta-1; phospholipase C-like protein 3", "tax_id": 10090, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:269437); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15583837;15702972;21041529;21262355;21750661;23540699;39627609", "class_list": "", "function": "Molecular cloning of PLC-eta1 and PLC-eta2., [RefSeq, PubMed]; PLC-eta1 is activated via intracellular calcium mobilization from the endoplasmic reticulum, and therefore amplifies G-protein coupled receptor mediated signaling, [RefSeq, PubMed]; Phospholipase C-eta was found to be expressed in mouse beta-cells, and knockout of that gene disrupts the action of exendin-4 to facilitate calcium-induced calcium release in the beta-cells of these mice. Erratum:[J Physiol. 2012 Mar 15;590(Pt 6):1511], [RefSeq, PubMed]; Study concludes that perinuclear PLCepsilon, scaffolded to mAKAP in cardiac myocytes, responds to hypertrophic stimuli to generate diacylglycerol (DAG) from PI4P in the Golgi apparatus, in close proximity to the nuclear envelope, to regulate activation of nuclear PKD and hypertrophic signaling pathways., [RefSeq, PubMed]; The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4KWH6;Q4KWH7;Q69ZS3;Q7TPQ1;Q8CFQ2", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4KWH5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64323-1", "uniprot_id": [ { "id": "PIGA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64323", "type": "external" } ], "mass": 54469.0, "length": 485, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit A", "gene_name": "Piga", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit A", "refseq_ac": [ { "id": "NP_035211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035211", "type": "external" } ], "gene_names_uniprotkb": "Piga", "gene_names_refseq": "Pig-a; Piga", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; 2.4.1.198; GlcNAc-PI synthesis protein; PIG-A; Phosphatidylinositol-glycan biosynthesis class A protein", "protein_names_refseq": "N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein; glcNAc-PI synthesis protein; phosphatidylinositol N-acetylglucosaminyltransferase subunit A; phosphatidylinositol glycan, class A; phosphatidylinositol-glycan biosynthesis class A protein; phosphatidylinositolglycan class A", "tax_id": 10090, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); autosomal recessive congenital ichthyosis 4B (Disease Ontology:DOID:0060713); multiple congenital anomalies-hypotonia-seizures syndrome 2 (Disease Ontology:DOID:0080139)", "pathway": " (mmu:18700); (R-MMU-162710)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;31219806;7734452;7851884", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD71;Q8CCQ6", "ec_number_list": [ { "id": "2.4.1.198", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.198", "type": "external" } ], "go_molecular_function": "GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789 endoplasmic reticulum membrane;GO:0030867 rough endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64323-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KX1-1", "uniprot_id": [ { "id": "MLF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KX1", "type": "external" } ], "mass": 28055.0, "length": 247, "protein_name": "Myeloid leukemia factor 2", "gene_name": "Mlf2", "organism": "Mouse", "refseq_name": "myeloid leukemia factor 2", "refseq_ac": [ { "id": "NP_001163812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163812", "type": "external" } ], "gene_names_uniprotkb": "Mlf2", "gene_names_refseq": "Mlf2", "protein_names_uniprotkb": "Myeloid leukemia factor 2; Myelodysplasia-myeloid leukemia factor 2", "protein_names_refseq": "Myelodysplasia-myeloid leukemia factor 2; myeloid leukemia factor 2 homolog; myeloid leukemia factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30853)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16452087;17114649;21183079;21750661;25428506;33300544;35820727;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99KX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1S3-1", "uniprot_id": [ { "id": "PIGN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1S3", "type": "external" } ], "mass": 105045.0, "length": 931, "protein_name": "GPI ethanolamine phosphate transferase 1", "gene_name": "Pign", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pign", "gene_names_refseq": "", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 1; 2.-.-.-; PIG-N; Phosphatidylinositol-glycan biosynthesis class N protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "multiple congenital anomalies-hypotonia-seizures syndrome 1 (Disease Ontology:DOID:0080138); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:27392); (R-MMU-162710)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10574991;21750661;31599954;40997131", "class_list": "glycogene", "function": "Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ethanolamine phosphate transferase that catalyzes an ethanolamine phosphate (EtNP) transfer from phosphatidylethanolamine (PE) to the 2-OH position of the first alpha-1,4-linked mannose of a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol and participates in the eighth step of the glycosylphosphatidylinositol-anchor biosynthesis (Probable). Also transfers the EtNP on a mannosyl GPI intermediate, 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) (Probable). May act as suppressor of replication stress and chromosome missegregation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0S6;Q8VCC3;Q9R1S1;Q9R1S2", "ec_number_list": [ { "id": "2.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R1S3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZV7-1", "uniprot_id": [ { "id": "PLDX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZV7", "type": "external" } ], "mass": 55635.0, "length": 500, "protein_name": "Plexin domain-containing protein 1", "gene_name": "Plxdc1", "organism": "Mouse", "refseq_name": "plexin domain-containing protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001157080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157080", "type": "external" } ], "gene_names_uniprotkb": "Plxdc1; Tem7", "gene_names_refseq": "2410003I07Rik; Plxdc1; Tem7", "protein_names_uniprotkb": "Plexin domain-containing protein 1; Tumor endothelial marker 7", "protein_names_refseq": "TEM7 related; plexin domain-containing protein 1 isoform 1 precursor; plexin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72324)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11559528;15574754;16202431;16574105;20919742;21750661;29500915", "class_list": "", "function": "A novel fusion expression system based on mouse TEM7 (tumor endothelial marker 7), which could facilitate protein expression., [RefSeq, PubMed]; Plays a critical role in endothelial cell capillary morphogenesis., [UniProtKB, PubMed]; Studies identify Plxdc1, Sema4D, and neuropilin-1 as novel LRP1-regulated cell-signaling proteins., [RefSeq, PubMed]; TEM7 is a novel protein whose cell surface expression is essential during endothelial cell capillary morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2A537;A2A538;Q29R73;Q8BM20;Q9CWV5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030425 dendrite", "go_biological_process": "GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91ZV7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHR9-1", "uniprot_id": [ { "id": "PIHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHR9", "type": "external" } ], "mass": 35583.0, "length": 315, "protein_name": "PIH1 domain-containing protein 2", "gene_name": "Pih1d2", "organism": "Mouse", "refseq_name": "PIH1 domain-containing protein 2", "refseq_ac": [ { "id": "NP_082576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082576", "type": "external" } ], "gene_names_uniprotkb": "Pih1d2", "gene_names_refseq": "2700059L22Rik; Pih1d2", "protein_names_uniprotkb": "PIH1 domain-containing protein 2", "protein_names_refseq": "PIH1 domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72614)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05CZ6;Q9CSM2", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDE8-1", "uniprot_id": [ { "id": "S68A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDE8", "type": "external" } ], "mass": 57898.0, "length": 519, "protein_name": "Solute carrier family 68 member 1", "gene_name": "Mfsd13a; Slc68a1", "organism": "Mouse", "refseq_name": "solute carrier family 68 member 1", "refseq_ac": [ { "id": "NP_083462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083462", "type": "external" } ], "gene_names_uniprotkb": "Mfsd13a; Slc68a1; Mfsd13a; Tmem180", "gene_names_refseq": "4930449A08Rik; 4930538D17Rik; Mfsd13a; Slc68a1; Tmem180", "protein_names_uniprotkb": "Solute carrier family 68 member 1; Major facilitator superfamily domain-containing 13A; Transmembrane protein 180", "protein_names_refseq": "major facilitator superfamily domain containing 13a; major facilitator superfamily domain-containing 13A; solute carrier family 68 member 1; transmembrane protein 180", "tax_id": 10090, "disease": "", "pathway": " (mmu:75146)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27802388", "class_list": "", "function": "May act as a cation symporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y49;Q8CD35", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PDE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCW2-1", "uniprot_id": [ { "id": "PLS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCW2", "type": "external" } ], "mass": 34052.0, "length": 307, "protein_name": "Phospholipid scramblase 2", "gene_name": "Plscr2", "organism": "Mouse", "refseq_name": "phospholipid scramblase 2", "refseq_ac": [ { "id": "NP_001182013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182013", "type": "external" } ], "gene_names_uniprotkb": "Plscr2", "gene_names_refseq": "Plscr2", "protein_names_uniprotkb": "Phospholipid scramblase 2; Ca(2+)-dependent phospholipid scramblase 2; PL scramblase 2", "protein_names_refseq": "PL scramblase 2; ca(2+)-dependent phospholipid scramblase 2; phospholipid scramblase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18828)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12509439;21750661;34428180;9485382", "class_list": "", "function": "May catalyze calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane., [UniProtKB, UniProtKB]; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB]; PLSCR2 is expressed predominantly in the cell nucleus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70233;Q921P6", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0032791 lead ion binding;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006955 immune response;GO:0071222 cellular response to lipopolysaccharide;GO:0017121 plasma membrane phospholipid scrambling;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN88-1", "uniprot_id": [ { "id": "PK1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN88", "type": "external" } ], "mass": 271977.0, "length": 2461, "protein_name": "Polycystin-1-like protein 2", "gene_name": "Pkd1l2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pkd1l2", "gene_names_refseq": "", "protein_names_uniprotkb": "Polycystin-1-like protein 2; PC1-like 2 protein; Polycystic kidney disease protein 1-like 2; Polycystin-1L2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76645)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12782129;21750661;25428506;35820727", "class_list": "glycogene", "function": "May function as a G protein-coupled receptor., [UniProtKB, UniProtKB]; May function as a G-protein-coupled receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 119, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TN88-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D187-1", "uniprot_id": [ { "id": "CIA2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D187", "type": "external" } ], "mass": 17667.0, "length": 163, "protein_name": "Cytosolic iron-sulfur assembly component 2B", "gene_name": "Ciao2b", "organism": "Mouse", "refseq_name": "cytosolic iron-sulfur assembly component 2B", "refseq_ac": [ { "id": "NP_081029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081029", "type": "external" } ], "gene_names_uniprotkb": "Ciao2b; Fam96b; Mip18", "gene_names_refseq": "1110019N10Rik; Ciao2b; Fam96b", "protein_names_uniprotkb": "Cytosolic iron-sulfur assembly component 2B; Mitotic spindle-associated MMXD complex subunit MIP18", "protein_names_refseq": "cytosolic iron-sulfur assembly component 2B; family with sequence similarity 96, member B; mitotic spindle-associated MMXD complex subunit MIP18", "tax_id": 10090, "disease": "", "pathway": " (mmu:68523)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18299400;21750661;21952136;22872234;23150669;25428506;30084848;30779550;33649389;34428180;35820727;37828378", "class_list": "", "function": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis., [UniProtKB, UniProtKB]; The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D187-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K74-1", "uniprot_id": [ { "id": "MED24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K74", "type": "external" } ], "mass": 109985.0, "length": 987, "protein_name": "Mediator of RNA polymerase II transcription subunit 24", "gene_name": "Med24", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 24 isoform 2", "refseq_ac": [ { "id": "NP_035999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035999", "type": "external" } ], "gene_names_uniprotkb": "Med24; D11Ertd307e; Thrap4; Trap100", "gene_names_refseq": "911GSE; D11Ertd307e; DRIP100; Gse2; Med24; Pparb2; Pparbp2; Thrap4; Trap100", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 24; Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; Trap100; mTRAP100", "protein_names_refseq": "genetic suppressor element 2; mTRAP100; mediator of RNA polymerase II transcription subunit 24 isoform 2; mediator of RNA polymerase II transcription subunit 24; peroxisome proliferation activation receptor binding protein 2; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 100 kDa; thyroid hormone receptor-associated protein complex 100 kDa component", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); intestinal disease (Disease Ontology:DOID:5295); neuropathy (Disease Ontology:DOID:870)", "pathway": " (mmu:23989)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10406464;11471062;11934987;12093747;17242355;21183079;21750661;31219806;31248101", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription., [UniProtKB, PubMed, PubMed]; MED24 was identified as a crucial oncogenic target of ERBB2 in lung tumor development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KFP0;Q8R004;Q9D277;Q9WVF1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0044877 protein-containing complex binding;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99K74-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXR4-1", "uniprot_id": [ { "id": "PIGC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXR4", "type": "external" } ], "mass": 33724.0, "length": 297, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "Pigc", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "refseq_ac": [ { "id": "NP_001034134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034134", "type": "external" } ], "gene_names_uniprotkb": "Pigc", "gene_names_refseq": "3110030E07Rik; Pigc", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; PIG-C; Phosphatidylinositol-glycan biosynthesis class C protein", "protein_names_refseq": "PIG-C; phosphatidylinositol N-acetylglucosaminyltransferase subunit C; phosphatidylinositol-glycan biosynthesis class C protein", "tax_id": 10090, "disease": "glycosylphosphatidylinositol biosynthesis defect 16 (Disease Ontology:DOID:0081223)", "pathway": " (mmu:67292); (R-MMU-162710)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene;glycosyltransferase", "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7H3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CXR4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY25-1", "uniprot_id": [ { "id": "MIS12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY25", "type": "external" } ], "mass": 24131.0, "length": 206, "protein_name": "Protein MIS12 homolog", "gene_name": "Mis12", "organism": "Mouse", "refseq_name": "protein MIS12 homolog", "refseq_ac": [ { "id": "NP_080269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080269", "type": "external" } ], "gene_names_uniprotkb": "Mis12", "gene_names_refseq": "2510025F08Rik; Mis12; Misc12", "protein_names_uniprotkb": "Protein MIS12 homolog", "protein_names_refseq": "MIS12 homolog; protein MIS12 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67139); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21750661;31599954;32341029", "class_list": "", "function": "Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V261;Q5QNU7;Q5QNU8;Q5QNU9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CY25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62276-1", "uniprot_id": [ { "id": "MED22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62276", "type": "external" } ], "mass": 22282.0, "length": 200, "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Med22", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 22 isoform 2", "refseq_ac": [ { "id": "NP_001029080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029080", "type": "external" } ], "gene_names_uniprotkb": "Med22; Surf5", "gene_names_refseq": "Med22; Surf-5; Surf5", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Surf-5; Surfeit locus protein 5", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 22 isoform 2; mediator of RNA polymerase II transcription subunit 22; surfeit gene 5; surfeit locus protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:20933)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;33208756;34428180;35820727;8586415", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ALA2;Q3TTZ9", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921D4-1", "uniprot_id": [ { "id": "MED6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921D4", "type": "external" } ], "mass": 28434.0, "length": 246, "protein_name": "Mediator of RNA polymerase II transcription subunit 6", "gene_name": "Med6", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 6 isoform 1", "refseq_ac": [ { "id": "NP_001334313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334313", "type": "external" } ], "gene_names_uniprotkb": "Med6; MED6", "gene_names_refseq": "1500012F11Rik; Med6", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 6; Mediator complex subunit 6", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 6 isoform 1; mediator of RNA polymerase II transcription subunit 6; mediator of RNA polymerase II transcription, subunit 6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69792)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23806337;25428506;30084848", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAK5;Q8BTP9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0001223 transcription coactivator binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q921D4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4X7-1", "uniprot_id": [ { "id": "PLCD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4X7", "type": "external" } ], "mass": 43810.0, "length": 378, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "gene_name": "Agpat4", "organism": "Mouse", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "refseq_ac": [ { "id": "NP_080920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080920", "type": "external" } ], "gene_names_uniprotkb": "Agpat4", "gene_names_refseq": "1500003P24Rik; Agpat4", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-AGP acyltransferase 4; 1-AGPAT 4; 1-acylglycerol-3-phosphate O-acyltransferase 4; 2.3.1.51; LPAAT-delta; Lysophosphatidic acid acyltransferase delta", "protein_names_refseq": "1-AGP acyltransferase 4; 1-AGPAT 4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta); 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); LPAAT-delta; lysophosphatidic acid acyltransferase-delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:68262); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15367102;21750661;24333445;28814640;29627383;31219806", "class_list": "", "function": "Agpat4/Lpaatdelta deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots, [RefSeq, PubMed]; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (PubMed:24333445)., [UniProtKB, PubMed, PubMed]; Study utilizing Lpaat-delta deficient mice identify an important role for murine Lpaat-delta in musculus soleus and extensor digitorum longus contractile force generation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKN0;Q9DB84", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4X7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0ZLH2-1", "uniprot_id": [ { "id": "PJVK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0ZLH2", "type": "external" } ], "mass": 39858.0, "length": 352, "protein_name": "Pejvakin", "gene_name": "Pjvk", "organism": "Mouse", "refseq_name": "pejvakin", "refseq_ac": [ { "id": "NP_001074180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074180", "type": "external" } ], "gene_names_uniprotkb": "Pjvk; Dfnb59; Gm1001", "gene_names_refseq": "Dfnb59; Gm1001; Pjvk", "protein_names_uniprotkb": "Pejvakin; Protein sirtaki", "protein_names_refseq": "autosomal recessive deafness type 59 protein homolog; deafness, autosomal recessive 59; pejvakin; protein sirtaki", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 59 (Disease Ontology:DOID:0110511)", "pathway": " (mmu:381375)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16804542;17329413;21750661;26544938;28089576;28209736;30936319", "class_list": "", "function": "Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage (PubMed:26544938, PubMed:30936319). Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy) (PubMed:26544938, PubMed:30936319). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss (PubMed:30936319). PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress (PubMed:30936319). In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation (PubMed:26544938, PubMed:30936319)., [UniProtKB, PubMed, PubMed]; Results demonstrate that pejvakin is required to sustain outer hair cell activity and survival in a cell-autonomous manner and imply pejvakin defects in sensory hearing loss rather than auditory neuropathy spectrum disorder; show that pejvakin forms protein complexes with Rho effectors, including ROCK2., [RefSeq, PubMed]; Studied role of pejvakin in preventing noise induced hearing loss by protecting auditory hair cells through mediating pexophagy, which plays a key role in noise-induced peroxisome proliferation; results suggest pejvakin acts as a redox-activated pexophagy receptor., [RefSeq, PubMed]; Study describes a genetic form of noise-induced hearing loss , by showing that pejvakin deficiency in mice and DFNB59 patients leads to hypervulnerability to sound, due to a peroxisomal deficiency., [RefSeq, PubMed]; The pejvakin allele described here introduces a premature stop codon, causes outer hair cell defects, and leads to progressive hearing loss., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0035253 ciliary rootlet;GO:0043025 neuronal cell body", "go_biological_process": "GO:1900063 regulation of peroxisome organization;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007605 sensory perception of sound;GO:0000302 response to reactive oxygen species;GO:0120045 stereocilium maintenance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q0ZLH2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LV7-1", "uniprot_id": [ { "id": "PIGX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LV7", "type": "external" } ], "mass": 28644.0, "length": 254, "protein_name": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit", "gene_name": "Pigx", "organism": "Mouse", "refseq_name": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit isoform 1 precursor", "refseq_ac": [ { "id": "NP_077784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077784", "type": "external" } ], "gene_names_uniprotkb": "Pigx", "gene_names_refseq": "2010319C14Rik; PIG-X; Pigx", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit; PIG-X; Phosphatidylinositol-glycan biosynthesis class X protein", "protein_names_refseq": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit isoform 1 precursor; GPI alpha-1,4-mannosyltransferase I, stabilizing subunit; phosphatidylinositol glycan, class X; phosphatidylinositol-glycan biosynthesis class X protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72084); (R-MMU-162710)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15635094;21750661;29400567;30084848", "class_list": "glycogene", "function": "A non-AUG translation initiation site (CUG) is used in rat Pigx, [RefSeq, PubMed]; Sept6 and Pigx might participate in the pathogenesis of high blood pressure., [RefSeq, PubMed]; Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99LV7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02816-1", "uniprot_id": [ { "id": "PIP_MOUSE", "url": "https://www.uniprot.org/uniprot/P02816", "type": "external" } ], "mass": 16823.0, "length": 146, "protein_name": "Prolactin-inducible protein homolog", "gene_name": "Pip", "organism": "Mouse", "refseq_name": "prolactin-inducible protein homolog precursor", "refseq_ac": [ { "id": "NP_032869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032869", "type": "external" } ], "gene_names_uniprotkb": "Pip", "gene_names_refseq": "GCDFP-15; GP17; Pip; SMGP", "protein_names_uniprotkb": "Prolactin-inducible protein homolog; 14 kDa submandibular gland protein; GCDFP-15; Gross cystic disease fluid protein 15; Prolactin-induced protein; SMGP", "protein_names_refseq": "14 kDa submandibular gland protein; gross cystic disease fluid protein 15; prolactin-inducible protein homolog precursor; prolactin-inducible protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:18716); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12890565;21750661;29536339;31447246;34379992;6546617;7925123", "class_list": "", "function": "Examined the endogenous pattern of mouse SMGP/PIP (mSMGP/mPIP) gene expression in mid-and late-embryonic, and in early postnatal development, [RefSeq, PubMed]; Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering., [RefSeq, PubMed]; Studies show that deficiency of PIP significantly affects intracellular signaling events leading to decreased pro-inflammatory cytokine production, and further confirms a role for PIP as an important immunoregulatory protein. This direct link between PIP and cell-mediated immunity, a key component of the immune system that is critical for cancer control, may have significant therapeutic implications., [RefSeq, PubMed]; We observed that the deficiency of Pip led to anomalies in the histology of lymphoid organs including the lymph nodes, spleen and thymus. We also observed anomalies in the morphology of the Eustachian tube and tympanic membrane in Pip deficient mice. Collectively, these data strongly suggest that Pip is an important regulator of immune responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64013;Q8K127;Q9QUG8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004190 aspartic-type endopeptidase activity;GO:0019864 IgG binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0002682 regulation of immune system process;GO:0070233 negative regulation of T cell apoptotic process;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02816-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZB6-1", "uniprot_id": [ { "id": "MED7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZB6", "type": "external" } ], "mass": 27205.0, "length": 233, "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "Med7", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 7", "refseq_ac": [ { "id": "NP_001098000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098000", "type": "external" } ], "gene_names_uniprotkb": "Med7; Crsp9", "gene_names_refseq": "1110063B05Rik; Crsp33; Crsp9; Med7", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 7; CRSP complex subunit 9; Cofactor required for Sp1 transcriptional activation subunit 9; Mediator complex subunit 7", "protein_names_refseq": "CRSP complex subunit 9; cofactor required for Sp1 transcriptional activation subunit 9; cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa; mediator of RNA polymerase II transcription subunit 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66213)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;25605945;31219806", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGV1;Q91VN3;Q9CWV8;Q9D0V9", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0019827 stem cell population maintenance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CZB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCX5-1", "uniprot_id": [ { "id": "MICU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCX5", "type": "external" } ], "mass": 54353.0, "length": 477, "protein_name": "Calcium uptake protein 1, mitochondrial", "gene_name": "Micu1", "organism": "Mouse", "refseq_name": "calcium uptake protein 1, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001278371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278371", "type": "external" } ], "gene_names_uniprotkb": "Micu1; Cbara1", "gene_names_refseq": "C730016L05Rik; Calc; Cbara1; Micu1", "protein_names_uniprotkb": "Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1 homolog", "protein_names_refseq": "calcium binding atopy-related autoantigen 1; calcium uptake protein 1, mitochondrial isoform 1; calcium uptake protein 1, mitochondrial", "tax_id": 10090, "disease": "myopathy with extrapyramidal signs (Disease Ontology:DOID:0111335); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:216001); (R-MMU-8949215); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "21685888;21750661;23409044;24560927;25428506;26956930;27477272;27818145;28135057;30084848;30504268;31219806;33300544;34428180;36206740;37098122;37695737;38018177;39163336", "class_list": "", "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:24560927, PubMed:27477272, PubMed:36206740). MICU1 and MICU2 (or MICU3) form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927, PubMed:27477272, PubMed:36206740). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 and MICU2 (or MICU3) induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:24560927). Also required to protect against manganese toxicity by preventing manganese uptake by MCU: mechanistically, manganese-binding to its EF-hand domains does not induce any conformational change, maintaining MCU pore occlusion (By similarity). Acts as a regulator of mitochondrial cristae structure independently of its ability to regulate the mitochondrial calcium uniporter channel (PubMed:37098122). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Isoform that regulates mitochondrial calcium uniporter (MCU) in the skeletal muscle (PubMed:27818145). Compared to other isoforms, this isoform has higher affinity for calcium, promoting mitochondrial calcium uptake at lower calcium concentrations (PubMed:27818145). This allows a rapid response of mitochondrial metabolism and ensures sustained ATP production needed for resistance and strenuous exercise (PubMed:27818145)., [UniProtKB, PubMed]; MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart., [RefSeq, PubMed]; SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK07;Q8BL84;Q8R1W0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VCX5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922V4-1", "uniprot_id": [ { "id": "PLRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922V4", "type": "external" } ], "mass": 56938.0, "length": 513, "protein_name": "Pleiotropic regulator 1", "gene_name": "Plrg1", "organism": "Mouse", "refseq_name": "pleiotropic regulator 1", "refseq_ac": [ { "id": "NP_058064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058064", "type": "external" } ], "gene_names_uniprotkb": "Plrg1", "gene_names_refseq": "Plrg1; Tango4", "protein_names_uniprotkb": "Pleiotropic regulator 1", "protein_names_refseq": "pleiotropic regulator 1, PRL1 homolog; pleiotropic regulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:53317); (R-MMU-72163)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18250455;19307306;21750661;25428506;25428507;25605945;30084848;30779550;31219806;34428180;36852467", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLRG1 is a critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during both embryonic development and adult tissue homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O55039", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q922V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEB6-1", "uniprot_id": [ { "id": "PHOCN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PEB6", "type": "external" } ], "mass": 26032.0, "length": 225, "protein_name": "MOB-like protein phocein", "gene_name": "Mob4", "organism": "Mouse", "refseq_name": "MOB-like protein phocein isoform 1", "refseq_ac": [ { "id": "NP_079559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079559", "type": "external" } ], "gene_names_uniprotkb": "Mob4; Mob3; Mobkl3; Phocn; Prei3", "gene_names_refseq": "2610109B12Rik; Mob4; Mobkl3; Phocn; Prei3", "protein_names_uniprotkb": "MOB-like protein phocein; Class II mMOB1; Mob1 homolog 3; Mob3; Mps one binder kinase activator-like 3; Preimplantation protein 3", "protein_names_refseq": "MOB-like protein phocein isoform 1; MOB1, Mps One Binder kinase activator-like 3; class II mMOB1; mob-like protein phocein; mob1 homolog 3; mob3; mps one binder kinase activator-like 3; preimplantation protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19070)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11319234;21750661;22872234;31219806;34203471;34428180;36210013", "class_list": "", "function": "Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS21;Q8BSA3;Q9CX28", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PEB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK91-1", "uniprot_id": [ { "id": "MLH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK91", "type": "external" } ], "mass": 84670.0, "length": 760, "protein_name": "DNA mismatch repair protein Mlh1", "gene_name": "Mlh1", "organism": "Mouse", "refseq_name": "DNA mismatch repair protein Mlh1 isoform 2", "refseq_ac": [ { "id": "NP_001311451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311451", "type": "external" } ], "gene_names_uniprotkb": "Mlh1", "gene_names_refseq": "1110035C23Rik; Mlh1", "protein_names_uniprotkb": "DNA mismatch repair protein Mlh1; MutL protein homolog 1", "protein_names_refseq": "DNA mismatch repair protein MLH1; DNA mismatch repair protein Mlh1 isoform 2; colon cancer, nonpolyposis type 2; mutL protein homolog 1", "tax_id": 10090, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); hereditary nonpolyposis colorectal cancer type 2 (Disease Ontology:DOID:0070274); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); malignant pleural mesothelioma (Disease Ontology:DOID:7474); sporadic breast cancer (Disease Ontology:DOID:8029); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:17350); (R-MMU-5358565)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;25428506;30084848;30899004;30949703;34428180;8674118", "class_list": "", "function": "Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (Mlh1-Pms2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with Mlh3 to form MutL gamma which plays a role in meiosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG77;Q62454", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005712 chiasma;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0000710 meiotic mismatch repair;GO:0045143 homologous chromosome segregation;GO:0007060 male meiosis chromosome segregation;GO:0016321 female meiosis chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JK91-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXN5-1", "uniprot_id": [ { "id": "MIOX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXN5", "type": "external" } ], "mass": 33164.0, "length": 285, "protein_name": "Inositol oxygenase", "gene_name": "Miox", "organism": "Mouse", "refseq_name": "inositol oxygenase", "refseq_ac": [ { "id": "NP_064361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064361", "type": "external" } ], "gene_names_uniprotkb": "Miox; Aldrl6; Rsor", "gene_names_refseq": "0610009I10Rik; Aldrl6; Miox; RSOR", "protein_names_uniprotkb": "Inositol oxygenase; 1.13.99.1; Aldehyde reductase-like 6; MI oxygenase; Myo-inositol oxygenase; Renal-specific oxidoreductase", "protein_names_refseq": "MI oxygenase; aldehyde reductase (aldose reductase)-like 6; aldehyde reductase 6, renal; aldehyde reductase-like 6; inositol oxygenase; renal-specific oxido-reducatse; renal-specific oxidoreductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56727); (R-MMU-1855183)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10944187;11880337;15504367;16330753;17012379;18364358;21750661;31437128;31616917;32169892;39145457", "class_list": "", "function": "Is developmentally regulated in kidney, exhibits a distinct spatiotemporal distribution, and probably plays a role in tubulogenesis., [RefSeq, PubMed]; Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein., [RefSeq, PubMed]; Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes., [RefSeq, PubMed]; RSOR activity is modulated by diverse mechanisms, and it is endowed with dual properties to channel glucose intermediaries, characteristic of hepatic aldehyde reductases, and to maintain osmoregulation, in diabetes., [RefSeq, PubMed]; These findings indicate that ferroptosis, an integral process in the pathogenesis of cisplatin-induced AKI, is modulated by the expression profile of MIOX., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5S8D0;Q91WQ8", "ec_number_list": [ { "id": "1.13.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.99.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0050661 NADP binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016234 inclusion body", "go_biological_process": "GO:0019310 inositol catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QXN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q765H6-1", "uniprot_id": [ { "id": "MGT5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q765H6", "type": "external" } ], "mass": 89473.0, "length": 792, "protein_name": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B", "gene_name": "Mgat5b", "organism": "Mouse", "refseq_name": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 1", "refseq_ac": [ { "id": "NP_766536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766536", "type": "external" } ], "gene_names_uniprotkb": "Mgat5b", "gene_names_refseq": "C330018B01; GNT-Vb; GnT-IX; GnTVB; Mgat5b; Vb; glcNAc-T", "protein_names_uniprotkb": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; 2.4.1.-; 2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; GNT-IX; GNT-Vb; GlcNAc-T Vb; Mannoside acetylglucosaminyltransferase 5B; N-acetylglucosaminyl-transferase Vb; N-acetylglucosaminyltransferase IX", "protein_names_refseq": "N-acetylglucosaminyl-transferase Vb; N-acetylglucosaminyltranferase VB; UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase b; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 1; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; beta1,6-N-acetylglucosaminyltransferase IX (GnT-IX); glcNAc-T Vb; mannoside acetylglucosaminyltransferase 5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:268510); (R-MMU-8932504)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14623122;16413118;21750661;21771782;22715095;24619417;30899004;37543361", "class_list": "glycogene;glycosyltransferase", "function": "A new epigenetic mechanism of brain-specific GnT-IX expression regulated by defined chromatin modifiers, providing new insights into the tissue-specific expression of glycosyltransferases., [RefSeq, PubMed]; Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth., [RefSeq, PubMed]; Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V., [RefSeq, PubMed]; Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan (By similarity). Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan (PubMed:22715095). Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway., [UniProtKB, UniProtKB, PubMed]; GnT-IX transcripts were restricted to the cerebrum, cerebellum, thymus and testis, whereas GnT-V transcripts were expressed ubiquitously in mouse tissues, [RefSeq, PubMed]; Revealed that the genomic region around the transcriptional start site of the acetylglucosaminyltransferase IX gene was highly associated with active chromatin histone marks in a neural cell-specific manner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7T8", "ec_number_list": [ { "id": "2.4.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 2931, "hit_score": 1.7, "record_id": "Q765H6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922T2-1", "uniprot_id": [ { "id": "MFAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922T2", "type": "external" } ], "mass": 38406.0, "length": 349, "protein_name": "Microfibril-associated glycoprotein 3", "gene_name": "Mfap3", "organism": "Mouse", "refseq_name": "microfibril-associated glycoprotein 3 precursor", "refseq_ac": [ { "id": "NP_663401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663401", "type": "external" } ], "gene_names_uniprotkb": "Mfap3", "gene_names_refseq": "2610509F16Rik; 2700079M14Rik; Mfap3", "protein_names_uniprotkb": "Microfibril-associated glycoprotein 3", "protein_names_refseq": "microfibril-associated glycoprotein 3 precursor; microfibril-associated glycoprotein 3; novel immunoglobulin domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:216760)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26495903;36210013;37828378", "class_list": "", "function": "Component of the elastin-associated microfibrils., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHK5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q922T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPL4-1", "uniprot_id": [ { "id": "METL9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPL4", "type": "external" } ], "mass": 36426.0, "length": 318, "protein_name": "Protein-L-histidine N-pros-methyltransferase", "gene_name": "Mettl9", "organism": "Mouse", "refseq_name": "protein-L-histidine N-pros-methyltransferase isoform 1 precursor", "refseq_ac": [ { "id": "NP_067529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067529", "type": "external" } ], "gene_names_uniprotkb": "Mettl9; MNCb-5680; drev", "gene_names_refseq": "0610012D09Rik; Drev; MNCb-5680; Mettl9; mMETTL9", "protein_names_uniprotkb": "Protein-L-histidine N-pros-methyltransferase; 2.1.1.-; DORA reverse strand protein; DREV; Methyltransferase-like protein 9; mMETTL9", "protein_names_refseq": "DORA reverse strand protein; methyltransferase-like protein 9; protein-L-histidine N-pros-methyltransferase isoform 1 precursor; protein-L-histidine N-pros-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:59052)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11132146;21750661;22872234;31219806;33563959;34218407;34428180;34562450", "class_list": "", "function": "Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34218407). Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature (PubMed:33563959, PubMed:34218407). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34218407). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959)., [UniProtKB, PubMed, PubMed]; SiRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9., [RefSeq, PubMed]; The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JG25;Q3TDX0;Q641L4;Q8R567;Q9EPL3;Q9JJ88", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0106370 protein-L-histidine N-pros-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EPL4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCD5-1", "uniprot_id": [ { "id": "MED17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCD5", "type": "external" } ], "mass": 72462.0, "length": 649, "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "Med17", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 17 isoform 1", "refseq_ac": [ { "id": "NP_659182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659182", "type": "external" } ], "gene_names_uniprotkb": "Med17; Crsp6; Trap80", "gene_names_refseq": "77kDa; C330002H14Rik; Crsp6; Med17; Trap80", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 17; CRSP complex subunit 6; Cofactor required for Sp1 transcriptional activation subunit 6; Mediator complex subunit 17; Thyroid hormone receptor-associated protein complex 80 kDa component", "protein_names_refseq": "CRSP complex subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD); mediator of RNA polymerase II transcription subunit 17 isoform 1; mediator of RNA polymerase II transcription subunit 17; thyroid hormone receptor-associated protein complex 80 kDa component", "tax_id": 10090, "disease": "infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (Disease Ontology:DOID:0111262)", "pathway": " (mmu:234959)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12037571;17132730;21750661;28223413;31219806;34428180", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYS6;Q99KQ1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X83-1", "uniprot_id": [ { "id": "METK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X83", "type": "external" } ], "mass": 43509.0, "length": 396, "protein_name": "S-adenosylmethionine synthase isoform type-1", "gene_name": "Mat1a", "organism": "Mouse", "refseq_name": "S-adenosylmethionine synthase isoform type-1", "refseq_ac": [ { "id": "NP_598414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598414", "type": "external" } ], "gene_names_uniprotkb": "Mat1a", "gene_names_refseq": "AdoMet; Ams; MATA1; MAT; Mat1a; SAMS1; SAMS", "protein_names_uniprotkb": "S-adenosylmethionine synthase isoform type-1; 2.5.1.6; AdoMet synthase 1; MAT 1; Methionine adenosyltransferase 1", "protein_names_refseq": "S-adenosylmethionine synthase isoform type-1; adoMet synthetase 1; methionine adenosyltransferase I, alpha", "tax_id": 10090, "disease": "hypermethioninemia (Disease Ontology:DOID:0050544); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:11720); (R-MMU-156581); (R-MMU-1614635); (R-MMU-2408508)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12060674;15033934;21750661;34349244;34428180;35232994;37453647;8314764", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, PubMed]; Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1 interplay promotes liver cancer tumorigenesis in mice and humans., [RefSeq, PubMed]; MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor. MAT1A-produced SAMe has a major role in ERK signaling & cyclin D1 regulation during liver regeneration & mitogenic signal response., [RefSeq, PubMed]; Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. Publication Status: Online-Only, [RefSeq, PubMed]; Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A, [RefSeq, PubMed]; This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0065003 protein-containing complex assembly;GO:0009087 L-methionine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91X83-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCL4-1", "uniprot_id": [ { "id": "MET15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCL4", "type": "external" } ], "mass": 45282.0, "length": 406, "protein_name": "12S rRNA N(4)-cytidine methyltransferase METTL15", "gene_name": "Mettl15", "organism": "Mouse", "refseq_name": "12S rRNA N(4)-cytidine methyltransferase METTL15 isoform a", "refseq_ac": [ { "id": "NP_084066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084066", "type": "external" } ], "gene_names_uniprotkb": "Mettl15; Mett5d1", "gene_names_refseq": "0610027B03Rik; Mett5d1; Mettl15", "protein_names_uniprotkb": "12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA m4C methyltransferase; 2.1.1.-; Methyltransferase 5 domain-containing protein 1; Methyltransferase-like protein 15", "protein_names_refseq": "12S rRNA N(4)-cytidine methyltransferase METTL15 isoform a; 12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA N4-methylcytidine methyltransferase; 12S rRNA m4C methyltransferase; methyltransferase 5 domain containing 1; methyltransferase 5 domain-containing protein 1; probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1; probable methyltransferase-like protein 15; putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76894)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;32573735;35682734", "class_list": "", "function": "METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue., [RefSeq, PubMed]; Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQI4", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070475 rRNA base methylation;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61845-1", "uniprot_id": [ { "id": "MEIG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61845", "type": "external" } ], "mass": 10823.0, "length": 88, "protein_name": "Meiosis-expressed gene 1 protein", "gene_name": "Meig1", "organism": "Mouse", "refseq_name": "meiosis-expressed gene 1 protein", "refseq_ac": [ { "id": "NP_032605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032605", "type": "external" } ], "gene_names_uniprotkb": "Meig1; MLZ-278; Meg1", "gene_names_refseq": "MLZ-278; Meg1; Meig1", "protein_names_uniprotkb": "Meiosis-expressed gene 1 protein; MLZ-278; Protein expressed in male leptotene and zygotene spermatocytes 278", "protein_names_refseq": "meiosis-expressed gene 1 protein; protein expressed in male leptotene and zygotene spermatocytes 278", "tax_id": 10090, "disease": "", "pathway": " (mmu:104362)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1390336;19805151;20339383;21750661;25248657;29393537;31219806;34673028;35257720;35547804", "class_list": "", "function": "A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation., [RefSeq, PubMed]; Essential for spermiogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells., [RefSeq, PubMed]; Mouse meiosis expressed gene 1 is not phosphorylated in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0002177 manchette", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008104 intracellular protein localization;GO:0051321 meiotic cell cycle;GO:0007288 sperm axoneme assembly;GO:1905198 manchette assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61845-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569E4-1", "uniprot_id": [ { "id": "MENT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q569E4", "type": "external" } ], "mass": 38118.0, "length": 350, "protein_name": "Protein MENT", "gene_name": "Gm128; Ment", "organism": "Mouse", "refseq_name": "protein MENT precursor", "refseq_ac": [ { "id": "NP_001020012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020012", "type": "external" } ], "gene_names_uniprotkb": "Gm128; Ment; Gm128", "gene_names_refseq": "Gm128; Ment; pmis1", "protein_names_uniprotkb": "Protein MENT; Methylated in normal thymocytes protein", "protein_names_refseq": "methylated in normal thymocytes protein; protein MENT precursor; protein MENT; protein missing in infertile spermatozoa 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229588)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22133874;22621904;31219806", "class_list": "", "function": "Identify Ment (Gm128) as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b, [RefSeq, PubMed]; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q569E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1A0-1", "uniprot_id": [ { "id": "METL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1A0", "type": "external" } ], "mass": 23662.0, "length": 209, "protein_name": "rRNA N(6)-adenosine-methyltransferase METTL5", "gene_name": "Mettl5", "organism": "Mouse", "refseq_name": "rRNA N(6)-adenosine-methyltransferase METTL5", "refseq_ac": [ { "id": "NP_083556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083556", "type": "external" } ], "gene_names_uniprotkb": "Mettl5", "gene_names_refseq": "2810410A08Rik; Mettl5", "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase METTL5; 2.1.1.-; Methyltransferase-like protein 5", "protein_names_refseq": "methyltransferase like 5; methyltransferase-like protein 5; rRNA N(6)-adenosine-methyltransferase METTL5; rRNA N6-adenosine-methyltransferase METTL5", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 72 (Disease Ontology:DOID:0080765)", "pathway": " (mmu:75422)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;31564433;32217665;32783360;34428180;35033535;36111643;37735874", "class_list": "", "function": "Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:32783360, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:32217665, PubMed:32783360)., [UniProtKB, PubMed, PubMed, PubMed]; Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos. Publication Status: Online-Only, [RefSeq, PubMed]; METTL5-mediated 18S rRNA m[6]A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression., [RefSeq, PubMed]; The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation., [RefSeq, PubMed]; The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031167 rRNA methylation;GO:0048863 stem cell differentiation;GO:0045727 positive regulation of translation;GO:0006364 rRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K1A0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J09-1", "uniprot_id": [ { "id": "MEP50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J09", "type": "external" } ], "mass": 36943.0, "length": 342, "protein_name": "Methylosome protein WDR77", "gene_name": "Wdr77", "organism": "Mouse", "refseq_name": "methylosome protein WDR77", "refseq_ac": [ { "id": "NP_081708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081708", "type": "external" } ], "gene_names_uniprotkb": "Wdr77; Mep50", "gene_names_refseq": "2610003I18Rik; 2610312E17Rik; Wdr77; p44/MEP50", "protein_names_uniprotkb": "Methylosome protein WDR77; MEP-50; Methylosome protein 50; WD repeat-containing protein 77", "protein_names_refseq": "MEP-50; WD repeat-containing protein 77; methylosome protein 50; methylosome protein WDR77", "tax_id": 10090, "disease": "", "pathway": " (mmu:70465); (R-MMU-191859); (R-MMU-3214858)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16712789;19584108;20519372;21183079;21750661;22645316;29706654;31432503;32782141;35197566;37563140;37828378", "class_list": "", "function": "MEP50 associated with the purinergic receptor P2X5 and is involved in osteoclast maturation., [RefSeq, PubMed]; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (By similarity). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles (By similarity). Might play a role in transcription regulation (By similarity). The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:19584108)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Substrate-recognition component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm1 in intestinal cells., [UniProtKB, PubMed]; The AR cofactor p44/WDR77 plays important roles in prostate growth and differentiation by modulating AR-target gene expression., [RefSeq, PubMed]; WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response. Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. doi: 10.1038/s41467-023-41712-w. PMID: 37749076] Publication Status: Online-Only, [RefSeq, PubMed]; Wdr77 ablation inhibited E2F3 activation and enhanced TGFbeta signaling, leading to attenuated cellular proliferation induced by loss of Pten., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFJ1;Q8BSH8;Q9CZY5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008327 methyl-CpG binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99J09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPL6-1", "uniprot_id": [ { "id": "MMP1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPL6", "type": "external" } ], "mass": 53492.0, "length": 463, "protein_name": "Interstitial collagenase B", "gene_name": "Mmp1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mmp1b; McolB", "gene_names_refseq": "", "protein_names_uniprotkb": "Interstitial collagenase B; 3.4.24.7; MMP-1b; Matrix metalloproteinase-1b; Mcol-B", "protein_names_refseq": "", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); carotid stenosis (Disease Ontology:DOID:13001); lung cancer (Disease Ontology:DOID:1324); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); atherosclerosis (Disease Ontology:DOID:1936); obstructive lung disease (Disease Ontology:DOID:2320); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); varicose veins (Disease Ontology:DOID:799); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); localized scleroderma (Disease Ontology:DOID:8472); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:83996); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-210991)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11113146;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0031334 positive regulation of protein-containing complex assembly;GO:0030574 collagen catabolic process;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPL6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61865-1", "uniprot_id": [ { "id": "MIA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61865", "type": "external" } ], "mass": 14593.0, "length": 130, "protein_name": "Melanoma-derived growth regulatory protein", "gene_name": "Mia", "organism": "Mouse", "refseq_name": "melanoma-derived growth regulatory protein precursor", "refseq_ac": [ { "id": "NP_062267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062267", "type": "external" } ], "gene_names_uniprotkb": "Mia; Cdrap; Mia1", "gene_names_refseq": "CD-RAP; Cdrap; Mia1; Mia", "protein_names_uniprotkb": "Melanoma-derived growth regulatory protein; CD-RAP; Cartilage-derived retinoic acid-sensitive protein; Melanoma inhibitory activity protein", "protein_names_refseq": "cartilage-derived retinoic acid-sensitive protein; melanoma inhibitory activity 1; melanoma inhibitory activity protein; melanoma-derived growth regulatory protein precursor; melanoma-derived growth regulatory protein", "tax_id": 10090, "disease": "osteonecrosis (Disease Ontology:DOID:10159)", "pathway": " (mmu:12587)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;30084848;31172672;34428180;36672165;7923218;9097023", "class_list": "", "function": "Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas., [UniProtKB]; MIA is a regulator of cellular senescence in human and murine melanocytes., [RefSeq, PubMed]; MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09086;P97495", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61865-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3C0-1", "uniprot_id": [ { "id": "MCMBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3C0", "type": "external" } ], "mass": 72891.0, "length": 642, "protein_name": "Mini-chromosome maintenance complex-binding protein", "gene_name": "Mcmbp", "organism": "Mouse", "refseq_name": "mini-chromosome maintenance complex-binding protein", "refseq_ac": [ { "id": "NP_666067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666067", "type": "external" } ], "gene_names_uniprotkb": "Mcmbp", "gene_names_refseq": "1110007A13Rik; MCM-BP; Mcmbp", "protein_names_uniprotkb": "Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein", "protein_names_refseq": "MCM (minichromosome maintenance deficient) binding protein; MCM-binding protein; mini-chromosome maintenance complex-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:210711)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;25153642;25605945;28528544;31219806;34428180", "class_list": "", "function": "Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3G1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030054 cell junction;GO:0042555 MCM complex", "go_biological_process": "GO:0051301 cell division;GO:0007062 sister chromatid cohesion;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R3C0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5UAK0-3", "uniprot_id": [ { "id": "MIER1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5UAK0", "type": "external" } ], "mass": 57908.0, "length": 511, "protein_name": "Mesoderm induction early response protein 1", "gene_name": "Mier1", "organism": "Mouse", "refseq_name": "mesoderm induction early response protein 1 isoform b", "refseq_ac": [ { "id": "NP_001034170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034170", "type": "external" } ], "gene_names_uniprotkb": "Mier1; Kiaa1610", "gene_names_refseq": "4933425I22Rik; 5830411K19Rik; Mier1; er1", "protein_names_uniprotkb": "Mesoderm induction early response protein 1; Early response 1; Er1; Mi-er1", "protein_names_refseq": "early response 1; mesoderm induction early response 1 homolog (Xenopus laevis; mesoderm induction early response protein 1 isoform b; mesoderm induction early response protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71148)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16147882;17242355;21183079;25428506;31219806;34428180;36210013;36934083", "class_list": "", "function": "Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1L3P9;B1AY29;B1AY34;Q5UAK1;Q5UAK2;Q5UAK3;Q6ZPL6;Q9D402", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000118 histone deacetylase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5UAK0-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60764-1", "uniprot_id": [ { "id": "MKRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60764", "type": "external" } ], "mass": 59434.0, "length": 544, "protein_name": "E3 ubiquitin-protein ligase makorin-3", "gene_name": "Mkrn3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase makorin-3", "refseq_ac": [ { "id": "NP_035876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035876", "type": "external" } ], "gene_names_uniprotkb": "Mkrn3; Zfp127; Znf127", "gene_names_refseq": "D7H15S9-1; Mkrn3; Zfp127", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase makorin-3; 2.3.2.27; RING-type E3 ubiquitin transferase makorin-3; Zinc finger protein 127", "protein_names_refseq": "E3 ubiquitin-protein ligase makorin-3; RING-type E3 ubiquitin transferase makorin-3; probable E3 ubiquitin-protein ligase makorin-3; zinc finger protein 127", "tax_id": 10090, "disease": "central precocious puberty 2 (Disease Ontology:DOID:0112309)", "pathway": " (mmu:22652)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10196368;10395905;12971993;23738509;33744966;34692086;36714607;37092553;37585624", "class_list": "", "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Acts as a key developmental timer that helps ensure puberty begins at the appropriate age, by inhibiting premature activation of the reproductive hormone cascade (PubMed:37092553). Epigenetically regulates GNRH1 transcription by disrupting the binding of methyl-DNA binding protein 3/MBD3 to the promoter of GNRH1. Mechanistically, mediates the non-proteolytic ubiquitination of MBD3 at multiple sites with 'Lys27' ubiquitin linkages and thereby regulates the methylation status of the genome, including GNRH1 promoter (PubMed:34692086). Modulates the stability and translation of GNRH1 mRNA by mediating the non-proteolytic ubiquitination of PABP family members PABPC1, PABPC3 and PABPC4 at multiple sites (PubMed:33744966). Also participates in the maintenance of genomic and epigenomic stability by regulating the abundance of APEX2 via 'Lys-48'-linked ubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity. Publication Status: Online-Only, [RefSeq, PubMed]; Methylation status of hypothalamic Mkrn3 promoter across puberty. Publication Status: Online-Only, [RefSeq, PubMed]; Mkrn3, encoding a RING zinc-finger protein, is imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY92;Q7TQE4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q60764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61847-1", "uniprot_id": [ { "id": "MEP1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61847", "type": "external" } ], "mass": 79501.0, "length": 704, "protein_name": "Meprin A subunit beta", "gene_name": "Mep1b", "organism": "Mouse", "refseq_name": "meprin A subunit beta precursor", "refseq_ac": [ { "id": "NP_032612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032612", "type": "external" } ], "gene_names_uniprotkb": "Mep1b; Mep-1b", "gene_names_refseq": "Mep-1b; Mep1b", "protein_names_uniprotkb": "Meprin A subunit beta; 3.4.24.63; Endopeptidase-2; Meprin B", "protein_names_refseq": "endopeptidase-2; meprin A subunit beta precursor; meprin A subunit beta; meprin B; meprin beta", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:17288)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11278902;16116208;1894622;1929422;21750661;30084848;35235058;8407940;8567689", "class_list": "", "function": "Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position (PubMed:11278902). Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components (By similarity)., [UniProtKB, UniProtKB, PubMed]; Meprin beta knockout reduces brain Abeta levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 8522, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q059K0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0017090 meprin A complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61847-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDC8-1", "uniprot_id": [ { "id": "S60A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDC8", "type": "external" } ], "mass": 56183.0, "length": 510, "protein_name": "Solute carrier family 60 member 1", "gene_name": "Mfsd4a; Slc60a1", "organism": "Mouse", "refseq_name": "solute carrier family 60 member 1 isoform b", "refseq_ac": [ { "id": "NP_001108134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108134", "type": "external" } ], "gene_names_uniprotkb": "Mfsd4a; Slc60a1; Mfsd4a; Mfsd4", "gene_names_refseq": "A230072B04; A930031D07Rik; Mfsd4a; Mfsd4; Slc60a1", "protein_names_uniprotkb": "Solute carrier family 60 member 1; Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4", "protein_names_refseq": "major facilitator superfamily domain containing 4; major facilitator superfamily domain-containing protein 4A; major facilitator superfamily domain-containing protein 4; solute carrier family 60 member 1 isoform b; solute carrier family 60 member 1", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:213006)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9688, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3M3;Q8C816;Q8CAF5", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQI3-1", "uniprot_id": [ { "id": "MLEC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQI3", "type": "external" } ], "mass": 32342.0, "length": 291, "protein_name": "Malectin", "gene_name": "Mlec", "organism": "Mouse", "refseq_name": "malectin precursor", "refseq_ac": [ { "id": "NP_780612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780612", "type": "external" } ], "gene_names_uniprotkb": "Mlec; Kiaa0152", "gene_names_refseq": "2410014A08Rik; ESTM19; Mlec; mKIAA0152", "protein_names_uniprotkb": "Malectin", "protein_names_refseq": "malectin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:109154); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25428506;31219806;34428180;37507081", "class_list": "", "function": "Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6C3;Q8CD40;Q8CI91", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051087 protein-folding chaperone binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6ZQI3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y86-1", "uniprot_id": [ { "id": "MK15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y86", "type": "external" } ], "mass": 60679.0, "length": 549, "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "Mapk15", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 15 isoform 1", "refseq_ac": [ { "id": "NP_808590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808590", "type": "external" } ], "gene_names_uniprotkb": "Mapk15; Erk7; Erk8", "gene_names_refseq": "ERK-8; Mapk15", "protein_names_uniprotkb": "Mitogen-activated protein kinase 15; 2.7.11.24; ERK-7; ERK-8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15", "protein_names_refseq": "ERK-7; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8; mitogen-activated protein kinase 15 isoform 1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:332110)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16484222;16624805;20395206;21183079;21190936;21750661;23351492;25823377;33300544;34428180;35820727", "class_list": "", "function": "A novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor., [RefSeq, PubMed]; Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (By similarity) (PubMed:25823377). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (By similarity). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (By similarity). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (PubMed:23351492). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions, [RefSeq, PubMed]; Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer, [RefSeq, PubMed]; Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:1905832 positive regulation of spindle assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80Y86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWY4-1", "uniprot_id": [ { "id": "MBLC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWY4", "type": "external" } ], "mass": 26923.0, "length": 260, "protein_name": "Metallo-beta-lactamase domain-containing protein 1", "gene_name": "Mblac1", "organism": "Mouse", "refseq_name": "metallo-beta-lactamase domain-containing protein 1", "refseq_ac": [ { "id": "NP_808546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808546", "type": "external" } ], "gene_names_uniprotkb": "Mblac1", "gene_names_refseq": "Mblac1", "protein_names_uniprotkb": "Metallo-beta-lactamase domain-containing protein 1; 3.1.27.-; Endoribonuclease MBLAC1", "protein_names_refseq": "endoribonuclease MBLAC1; metallo-beta-lactamase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:330216)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38083729", "class_list": "", "function": "Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage., [UniProtKB, UniProtKB]; Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHU7", "ec_number_list": [ { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0031124 mRNA 3'-end processing;GO:0008334 histone mRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BWY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE47-1", "uniprot_id": [ { "id": "S49A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE47", "type": "external" } ], "mass": 54646.0, "length": 516, "protein_name": "Solute carrier family 49 member A3", "gene_name": "Slc49a3", "organism": "Mouse", "refseq_name": "solute carrier family 49 member A3 isoform 1", "refseq_ac": [ { "id": "NP_766471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766471", "type": "external" } ], "gene_names_uniprotkb": "Slc49a3; Mfsd7a", "gene_names_refseq": "4732482E20Rik; Mfsd7a; Mfsd7; Slc49a3", "protein_names_uniprotkb": "Solute carrier family 49 member A3; Major facilitator superfamily domain-containing protein 7A", "protein_names_refseq": "major facilitator superfamily domain containing 7A; major facilitator superfamily domain-containing protein 7A; major facilitator superfamily domain-containing protein 7; solute carrier family 49 member A3 isoform 1; solute carrier family 49 member A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:243197)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505K1", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CE47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4G6-1", "uniprot_id": [ { "id": "MGT5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4G6", "type": "external" } ], "mass": 84551.0, "length": 740, "protein_name": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A", "gene_name": "Mgat5", "organism": "Mouse", "refseq_name": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A", "refseq_ac": [ { "id": "NP_660110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660110", "type": "external" } ], "gene_names_uniprotkb": "Mgat5", "gene_names_refseq": "4930471A21Rik; 5330407H02Rik; GlcNAc-TV; Mgat5", "protein_names_uniprotkb": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; 2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; GNT-V; GlcNAc-T V; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V; Secreted GNT-V; Secreted beta-1,6-N-acetylglucosaminyltransferase V", "protein_names_refseq": "GNT-V; N-acetylglucosaminyl-transferase V; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; beta1,6N-acetylglucosaminyltransferase V; glcNAc-T V", "tax_id": 10090, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:107895); (R-MMU-975577)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10700233;11217864;12122020;14561752;15459394;22715095;37019682;37172586;37828378;38912584", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10700233, PubMed:14561752, PubMed:22715095). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10700233, PubMed:12122020, PubMed:14561752, PubMed:15459394, PubMed:22715095). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration (PubMed:10700233, PubMed:14561752, PubMed:15459394). MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling (PubMed:15459394). Required for efficient interaction between TGFB1 and its receptor (PubMed:15459394). Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF (PubMed:15459394). MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways (PubMed:14561752). Promotes cell migration (PubMed:14561752, PubMed:15459394). Contributes to the regulation of the inflammatory response (PubMed:11217864, PubMed:15459394). MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens (PubMed:11217864). Required for normal leukocyte evasation and accumulation at sites of inflammation (PubMed:15459394). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells., [RefSeq, PubMed]; N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix., [UniProtKB, UniProtKB]; Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0004864 protein phosphatase inhibitor activity;GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0006487 protein N-linked glycosylation;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 2831, "hit_score": 1.4, "record_id": "Q8R4G6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE43-1", "uniprot_id": [ { "id": "METRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE43", "type": "external" } ], "mass": 34530.0, "length": 311, "protein_name": "Meteorin-like protein", "gene_name": "Metrnl", "organism": "Mouse", "refseq_name": "meteorin-like protein precursor", "refseq_ac": [ { "id": "NP_659046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659046", "type": "external" } ], "gene_names_uniprotkb": "Metrnl", "gene_names_refseq": "9430048M07Rik; Metrnl", "protein_names_uniprotkb": "Meteorin-like protein; Subfatin", "protein_names_refseq": "cometin; meteorin-like protein precursor; meteorin-like protein; subfatin", "tax_id": 10090, "disease": "", "pathway": " (mmu:210029)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;21985865;24393292;24906147;25428506;31219806;34428180;36210013;37880599;38745648;39190657", "class_list": "", "function": "Cometin is a novel neurotrophic factor(meteorin protein family) that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo., [RefSeq, PubMed]; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures., [UniProtKB, PubMed]; Meteorin-like/Meteorin-beta protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Metrnl inhibits choroidal neovascularization by attenuating the choroidal inflammation via inactivating the UCHL-1/NF-kappaB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin, [RefSeq, PubMed]; Study reports the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure; increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines., [RefSeq, PubMed]; Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-beta1/Smads signaling pathway: A potential therapeutic target. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1J2", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0009409 response to cold;GO:0050873 brown fat cell differentiation;GO:0050728 negative regulation of inflammatory response;GO:0097009 energy homeostasis;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VE43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WP0-1", "uniprot_id": [ { "id": "MASP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WP0", "type": "external" } ], "mass": 75517.0, "length": 685, "protein_name": "Mannan-binding lectin serine protease 2", "gene_name": "Masp2", "organism": "Mouse", "refseq_name": "mannan-binding lectin serine protease 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001003893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003893", "type": "external" } ], "gene_names_uniprotkb": "Masp2", "gene_names_refseq": "MASP-2; MAp19; Masp2", "protein_names_uniprotkb": "Mannan-binding lectin serine protease 2; 3.4.21.104; MASP-2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2", "protein_names_refseq": "mannan-binding lectin serine peptidase 2; mannan-binding lectin serine protease 2 isoform 1 precursor; mannan-binding lectin serine protease 2; mannose-binding protein-associated serine protease 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17175); (R-MMU-166662); (R-MMU-2855086)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10586086;15672593;15826378;16944957;29187734;30084848;31869396;34428180;38807149;9794427", "class_list": "glycogene", "function": "Highly conserved intron sequences. Restricted expression contrasts with the ubiquitous expression of neighboring genes., [RefSeq, PubMed]; Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury. Publication Status: Online-Only, [RefSeq, PubMed]; Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin., [UniProtKB, UniProtKB]; Recombinant protein of masp2 was made and purified., [RefSeq, PubMed]; Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway., [UniProtKB, UniProtKB]; That MASP-2 deficiency can increase susceptibility to adult Herpes simplex virus encephalitis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1ARY2;B1ARY3;Q9QXA4;Q9QXD2;Q9QXD5;Q9Z338", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.104", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.104", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91WP0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YR5-3", "uniprot_id": [ { "id": "EFNMT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YR5", "type": "external" } ], "mass": 78757.0, "length": 698, "protein_name": "eEF1A lysine and N-terminal methyltransferase", "gene_name": "Mettl13", "organism": "Mouse", "refseq_name": "eEF1A lysine and N-terminal methyltransferase isoform 1", "refseq_ac": [ { "id": "NP_659126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659126", "type": "external" } ], "gene_names_uniprotkb": "Mettl13; EEF1AKNMT; FEAT", "gene_names_refseq": "5630401D24Rik; Eef1aknmt; Mettl13", "protein_names_uniprotkb": "eEF1A lysine and N-terminal methyltransferase; Methyltransferase-like protein 13; eEF1A-KNMT", "protein_names_refseq": "EEF1A lysine and N-terminal methyltransferase; eEF1A lysine and N-terminal methyltransferase isoform 1; eEF1A-KNMT; methyltransferase like 13; methyltransferase-like protein 13", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:71449)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "27659353;29408807;30178547;34428180;37450238", "class_list": "", "function": "Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (By similarity). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (By similarity). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (By similarity). Has no activity towards core histones H2A, H2B, H3 and H4 (By similarity)., [UniProtKB, UniProtKB]; Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure., [RefSeq, PubMed]; Results suggest that FEAT facilitates the INSL3 production in testicular Leydig cells that is essential for transabdominal testis migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF24;Q3TFY3;Q69ZX4;Q8BWN2;Q8BX81", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91YR5-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921V5-1", "uniprot_id": [ { "id": "MGAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921V5", "type": "external" } ], "mass": 51030.0, "length": 442, "protein_name": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat2", "organism": "Mouse", "refseq_name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase precursor", "refseq_ac": [ { "id": "NP_666147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666147", "type": "external" } ], "gene_names_uniprotkb": "Mgat2", "gene_names_refseq": "CDGS2; GLCNACTII; GNT-II; GNT2; Mgat2", "protein_names_uniprotkb": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.143; Beta-1,2-N-acetylglucosaminyltransferase II; GNT-II; GlcNAc-T II; Mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II", "protein_names_refseq": "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase precursor; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; beta-1,2-N-acetylglucosaminyltransferase II; glcNAc-T II", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIa (Disease Ontology:DOID:0070253)", "pathway": " (mmu:217664); (R-MMU-975578)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11805078;12576479;12621063;25428506;30084848;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "MGAT2 is a monoacylglycerol acyltransferase expressed in the small intestine, [RefSeq, PubMed]; MGAT2 may play an important role in dietary fat absorption, [RefSeq, PubMed]; Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9384, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6X4;Q8C3Z6", "ec_number_list": [ { "id": "2.4.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.143", "type": "external" } ], "go_molecular_function": "GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 8635, "hit_score": 1.1, "record_id": "Q921V5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921Y4-1", "uniprot_id": [ { "id": "MFSD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921Y4", "type": "external" } ], "mass": 49679.0, "length": 450, "protein_name": "Solute carrier family 61 member 1", "gene_name": "Slc61a1", "organism": "Mouse", "refseq_name": "solute carrier family 61 member 1", "refseq_ac": [ { "id": "NP_598861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598861", "type": "external" } ], "gene_names_uniprotkb": "Slc61a1; Mfsd5", "gene_names_refseq": "AW556797; D15Mgi27; Mfsd5; Slc61a1", "protein_names_uniprotkb": "Solute carrier family 61 member 1; Major facilitator superfamily domain-containing protein 5; Molybdate transporter 2 homolog; Molybdate-anion transporter", "protein_names_refseq": "major facilitator superfamily domain-containing protein 5; molybdate transporter 2 homolog; molybdate-anion transporter; solute carrier family 61 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106073)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27272503;34428180", "class_list": "", "function": "Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum., [UniProtKB, UniProtKB]; Results show that Mfsd5 and Mfsd11 are both affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. Moreover, the first histological mapping of MFSD5 and MFSD11 shows ubiquitous expression in the periphery and the central nervous system of mice, where the proteins are expressed in excitatory and inhibitory mouse brain neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015098 molybdate ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0042594 response to starvation;GO:0032094 response to food;GO:0015689 molybdate ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q921Y4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWV1-1", "uniprot_id": [ { "id": "MCM8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWV1", "type": "external" } ], "mass": 92371.0, "length": 833, "protein_name": "DNA helicase MCM8", "gene_name": "Mcm8", "organism": "Mouse", "refseq_name": "DNA helicase MCM8 isoform a", "refseq_ac": [ { "id": "NP_001277983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277983", "type": "external" } ], "gene_names_uniprotkb": "Mcm8", "gene_names_refseq": "5730432L01Rik; Mcm8", "protein_names_uniprotkb": "DNA helicase MCM8; 5.6.2.4; DNA 3'-5' helicase MCM8; Minichromosome maintenance 8", "protein_names_refseq": "DNA 3'-5' helicase MCM8; DNA helicase MCM8 isoform a; DNA helicase MCM8; DNA replication licensing factor MCM8; minichromosome maintenance deficient 8", "tax_id": 10090, "disease": "primary ovarian insufficiency 10 (Disease Ontology:DOID:0080867)", "pathway": " (mmu:66634); (R-MMU-176187); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "20485683;22771120;25428506;31219806;31509747;34428180;38858601;39195969", "class_list": "", "function": "Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (By similarity). Probably by regulating HR, plays a key role during gametogenesis (PubMed:22771120). Stabilizes MCM9 protein (By similarity)., [UniProtKB, UniProtKB, PubMed]; MCM8 and MCM9 form a complex and that they coregulate their stability., [RefSeq, PubMed]; MCM8 interacts with DDX5 to promote R-loop resolution., [RefSeq, PubMed]; MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. Erratum:[Cell Rep. 2026 Jan 27;45(1):116846. doi: 10.1016/j.celrep.2025.116846. PMID: 41417734], [RefSeq, PubMed]; MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVM8;A2AVM9;Q3UZG5;Q80US2;Q80VI0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0000724 double-strand break repair via homologous recombination;GO:0007292 female gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CWV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXC3-1", "uniprot_id": [ { "id": "MGME1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXC3", "type": "external" } ], "mass": 38391.0, "length": 338, "protein_name": "Mitochondrial genome maintenance exonuclease 1", "gene_name": "Mgme1", "organism": "Mouse", "refseq_name": "mitochondrial genome maintenance exonuclease 1", "refseq_ac": [ { "id": "NP_001276559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276559", "type": "external" } ], "gene_names_uniprotkb": "Mgme1", "gene_names_refseq": "8430406I07Rik; Mgme1", "protein_names_uniprotkb": "Mitochondrial genome maintenance exonuclease 1; 3.1.-.-", "protein_names_refseq": "mitochondrial genome maintainance exonuclease 1; mitochondrial genome maintenance exonuclease 1", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 11 (Disease Ontology:DOID:0080129)", "pathway": " (mmu:74528)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22872234;23434322;29572490;31219806;34428180;36210013;38432635", "class_list": "", "function": "Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications., [RefSeq, PubMed]; MGME1 is part of a termination complex acting at the end of the D-loop region where it modulates mtDNA replication and H-strand transcription termination. Mice with MGME1 deficiency accumulate a long linear subgenomic mtDNA species, but do not develop progeria. Publication Status: Online-Only, [RefSeq, PubMed]; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANA5;Q3TIC0;Q543Z8", "ec_number_list": [], "go_molecular_function": "GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0017108 5'-flap endonuclease activity;GO:0008297 single-stranded DNA exodeoxyribonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CXC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D967-1", "uniprot_id": [ { "id": "MGDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D967", "type": "external" } ], "mass": 18582.0, "length": 164, "protein_name": "Magnesium-dependent phosphatase 1", "gene_name": "Mdp1", "organism": "Mouse", "refseq_name": "magnesium-dependent phosphatase 1", "refseq_ac": [ { "id": "NP_075886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075886", "type": "external" } ], "gene_names_uniprotkb": "Mdp1", "gene_names_refseq": "1810034K20Rik; Mdp1", "protein_names_uniprotkb": "Magnesium-dependent phosphatase 1; 3.1.3.-; 3.1.3.48; MDP-1", "protein_names_refseq": "MDP-1; magnesium-dependent phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67881)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10889041;11601995;15461449;31219806;36210013", "class_list": "", "function": "Magnesium-dependent phosphatase which may act as a tyrosine phosphatase., [UniProtKB, PubMed, PubMed, PubMed]; X ray crystallography of MDP-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003993 acid phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0030389 fructosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D967-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERV1-1", "uniprot_id": [ { "id": "MKRN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERV1", "type": "external" } ], "mass": 46597.0, "length": 416, "protein_name": "E3 ubiquitin-protein ligase makorin-2", "gene_name": "Mkrn2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase makorin-2", "refseq_ac": [ { "id": "NP_075779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075779", "type": "external" } ], "gene_names_uniprotkb": "Mkrn2", "gene_names_refseq": "2610002L04Rik; Mkrn2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase makorin-2; 2.3.2.27; RING-type E3 ubiquitin transferase makorin-2", "protein_names_refseq": "E3 ubiquitin-protein ligase makorin-2; Makorin RING zinc-finger protein 2; RING-type E3 ubiquitin transferase makorin-2; probable E3 ubiquitin-protein ligase makorin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67027)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11597136;25428506;26495903;28008940;28378844;30084848;31489847;34428180;36967804;40021952", "class_list": "", "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:28378844). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappa-B transactivation and negatively regulating inflammatory responses (PubMed:28378844). Plays a role in the regulation of spermiation and in male fertility (PubMed:28008940)., [UniProtKB, PubMed, PubMed]; MKRN2 knockout causes male infertility through decreasing STAT1, SIX4, and TNC expression. Publication Status: Online-Only, [RefSeq, PubMed]; Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTY9;Q9D0L9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002862 negative regulation of inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ26-1", "uniprot_id": [ { "id": "MEFV_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ26", "type": "external" } ], "mass": 86409.0, "length": 767, "protein_name": "Pyrin", "gene_name": "Mefv", "organism": "Mouse", "refseq_name": "pyrin isoform 3", "refseq_ac": [ { "id": "NP_062326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062326", "type": "external" } ], "gene_names_uniprotkb": "Mefv", "gene_names_refseq": "FMF; Mefv; TRIM20; pyrin", "protein_names_uniprotkb": "Pyrin", "protein_names_refseq": "familial mediterranean fever; marenostrin; pyrin isoform 3", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Sweet syndrome (Disease Ontology:DOID:0080746); IgA vasculitis (Disease Ontology:DOID:11123); asthma (Disease Ontology:DOID:2841); familial Mediterranean fever (Disease Ontology:DOID:2987); lung disease (Disease Ontology:DOID:850); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:54483); (R-MMU-844456)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10818206;12667444;23226472;25428506;27482109;34471287;37787552", "class_list": "", "function": "Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:34471287). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (By similarity). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity)., [UniProtKB, UniProtKB, PubMed]; Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes., [RefSeq, PubMed]; Pyrin has a critical role in the innate immune response, possibly by acting on ASC, a known caspase-1 activator, [RefSeq, PubMed]; These results are consistent with a model in which pyrin acts to limit the release of IL-1beta generated by activation and assembly of inflammasomes in response to subclinical immune challenges., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QN30", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0032651 regulation of interleukin-1 beta production;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032691 negative regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJ26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0S3-1", "uniprot_id": [ { "id": "MMP17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0S3", "type": "external" } ], "mass": 64333.0, "length": 578, "protein_name": "Matrix metalloproteinase-17", "gene_name": "Mmp17", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-17 preproprotein", "refseq_ac": [ { "id": "NP_035976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035976", "type": "external" } ], "gene_names_uniprotkb": "Mmp17; Mt4mmp", "gene_names_refseq": "MT4-MMP; MT4MMP; MTMMP4; Mmp17", "protein_names_uniprotkb": "Matrix metalloproteinase-17; 3.4.24.-; MMP-17; MT-MMP 4; MT4-MMP; MT4MMP; MTMMP4; Membrane-type matrix metalloproteinase 4; Membrane-type-4 matrix metalloproteinase", "protein_names_refseq": "matrix metalloproteinase-17 preproprotein; matrix metalloproteinase-17; membrane-type matrix metalloproteinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:23948); (R-MMU-1592389)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10471807;10567400;10799478;37869014", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin., [UniProtKB, PubMed]; Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UM9", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0001822 kidney development;GO:0042756 drinking behavior;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0S3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1B5-1", "uniprot_id": [ { "id": "MD2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1B5", "type": "external" } ], "mass": 23598.0, "length": 205, "protein_name": "Mitotic spindle assembly checkpoint protein MAD2A", "gene_name": "Mad2l1", "organism": "Mouse", "refseq_name": "mitotic spindle assembly checkpoint protein MAD2A", "refseq_ac": [ { "id": "NP_062372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062372", "type": "external" } ], "gene_names_uniprotkb": "Mad2l1; Mad2a", "gene_names_refseq": "MAD2; Mad2l1", "protein_names_uniprotkb": "Mitotic spindle assembly checkpoint protein MAD2A; MAD2-like protein 1; Mitotic arrest deficient 2-like protein 1", "protein_names_refseq": "MAD2 (mitotic arrest deficient, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic spindle assembly checkpoint protein MAD2A", "tax_id": 10090, "disease": "microcephaly (Disease Ontology:DOID:10907); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:56150); (R-MMU-141405); (R-MMU-141430); (R-MMU-141444); (R-MMU-174184); (R-MMU-176409); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "10892650;22645316;25605945;28528544;31219806;34428180;36247080;37725942", "class_list": "", "function": "Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (By similarity). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (By similarity)., [UniProtKB, UniProtKB]; Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence. Publication Status: Online-Only, [RefSeq, PubMed]; MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI53", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division;GO:0045930 negative regulation of mitotic cell cycle;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0042177 negative regulation of protein catabolic process;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1B5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z126-1", "uniprot_id": [ { "id": "PLF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z126", "type": "external" } ], "mass": 11243.0, "length": 105, "protein_name": "Platelet factor 4", "gene_name": "Pf4", "organism": "Mouse", "refseq_name": "platelet factor 4 precursor", "refseq_ac": [ { "id": "NP_064316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064316", "type": "external" } ], "gene_names_uniprotkb": "Pf4; Cxcl4; Scyb4", "gene_names_refseq": "Cxcl4; Pf4; Scyb4", "protein_names_uniprotkb": "Platelet factor 4; C-X-C motif chemokine 4; PF-4", "protein_names_refseq": "C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; platelet factor 4 precursor", "tax_id": 10090, "disease": "antiphospholipid syndrome (Disease Ontology:DOID:2988); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); retinal degeneration (Disease Ontology:DOID:8466); diabetic retinopathy (Disease Ontology:DOID:8947); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:56744); (R-MMU-114608); (R-MMU-202733); (R-MMU-380108); (R-MMU-418594); (R-MMU-9769739)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10319581;11468158;18250455;21750661;30084848;34428180;38547695;38577984;38657496", "class_list": "", "function": "CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-beta1/Smad2/3 signaling in mouse viral myocarditis., [RefSeq, PubMed]; CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis., [RefSeq, PubMed]; Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity., [UniProtKB, UniProtKB]; Platelet factor 4 promotes deep venous thrombosis by regulating the formation of neutrophil extracellular traps., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0031982 vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z126-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAC9-1", "uniprot_id": [ { "id": "PO5F2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAC9", "type": "external" } ], "mass": 36411.0, "length": 329, "protein_name": "POU domain, class 5, transcription factor 2", "gene_name": "Pou5f2", "organism": "Mouse", "refseq_name": "POU domain, class 5, transcription factor 2", "refseq_ac": [ { "id": "NP_083591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083591", "type": "external" } ], "gene_names_uniprotkb": "Pou5f2; Sprm1", "gene_names_refseq": "1700013G10Rik; Pou5f2; SPRM-1; Sprm1", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 2; SPRM-1; Sperm 1 POU domain transcription factor", "protein_names_refseq": "POU domain, class 5, transcription factor 2; sperm 1 POU domain transcription factor; sperm-associated POU domain protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75507)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;7908264", "class_list": "", "function": "Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVS2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A259-1", "uniprot_id": [ { "id": "PK2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A259", "type": "external" } ], "mass": 87234.0, "length": 760, "protein_name": "Polycystin-2-like protein 1", "gene_name": "Pkd2l1", "organism": "Mouse", "refseq_name": "polycystin-2-like protein 1", "refseq_ac": [ { "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "type": "external" } ], "gene_names_uniprotkb": "Pkd2l1; Trpp3", "gene_names_refseq": "B830002B15; PCL; PKD2L; Pkd2l1; Pkdl; TRPP3", "protein_names_uniprotkb": "Polycystin-2-like protein 1; Polycystic kidney disease 2-like 1 protein; Polycystin-2 homolog; Polycystin-2L1", "protein_names_refseq": "polycystic kidney disease 2-like 1 protein; polycystin-2 homolog; polycystin-2-like protein 1; polycystin-2L1; polycystin-L", "tax_id": 10090, "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:329064)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;15548533;16805797;16891422;16929298;18156604;18535624;19464260;19833970;20406802;20408813;20538909;21098668;21185261;21625513;22420714;24336288;24336289;25820328;28553944;28904867;29567962;34381056;37686387", "class_list": "", "function": "A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting Neurons in Spinal Cords of Rodents, Carnivores, and Primates. Publication Status: Online-Only, [RefSeq, PubMed]; Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:15548533, PubMed:28904867). Also forms functional heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:15548533, PubMed:16891422, PubMed:18535624, PubMed:20538909, PubMed:21185261, PubMed:24336289, PubMed:34381056). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:16891422, PubMed:16929298, PubMed:18535624, PubMed:19464260, PubMed:20406802, PubMed:20538909, PubMed:21098668, PubMed:21185261, PubMed:21625513, PubMed:22420714, PubMed:29567962). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:18535624, PubMed:19464260, PubMed:20406802, PubMed:20538909, PubMed:22420714, PubMed:28904867, PubMed:29567962). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336288, PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (By similarity). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (PubMed:15548533). May play a role in the perception of carbonation taste (PubMed:19833970). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (PubMed:28553944)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PKD2L1 forms functional cation channels on the plasma membrane by interacting with PKD1, [RefSeq, PubMed]; Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer., [RefSeq, PubMed]; These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14B55;Q14B73;Q80ZH4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051262 protein tetramerization;GO:0051289 protein homotetramerization;GO:0055085 transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "A2A259-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XF0-1", "uniprot_id": [ { "id": "PNPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XF0", "type": "external" } ], "mass": 30114.0, "length": 261, "protein_name": "Pyridoxine-5'-phosphate oxidase", "gene_name": "Pnpo", "organism": "Mouse", "refseq_name": "pyridoxine-5'-phosphate oxidase", "refseq_ac": [ { "id": "NP_598782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598782", "type": "external" } ], "gene_names_uniprotkb": "Pnpo", "gene_names_refseq": "Pnpo", "protein_names_uniprotkb": "Pyridoxine-5'-phosphate oxidase; 1.4.3.5; Pyridoxamine-phosphate oxidase", "protein_names_refseq": "pyridoxamine-phosphate oxidase; pyridoxine-5'-phosphate oxidase", "tax_id": 10090, "disease": "pyridoxamine 5'-phosphate oxidase deficiency (Disease Ontology:DOID:0111329); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:103711); (R-MMU-964975)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;25428506;34428180", "class_list": "", "function": "Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP70;Q3U445;Q3U4X1", "ec_number_list": [ { "id": "1.4.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.5", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0010181 FMN binding;GO:0004733 pyridoxamine phosphate oxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042816 vitamin B6 metabolic process;GO:0008615 pyridoxine biosynthetic process;GO:0042823 pyridoxal phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3K7-1", "uniprot_id": [ { "id": "PLCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3K7", "type": "external" } ], "mass": 31011.0, "length": 278, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase beta", "gene_name": "Agpat2", "organism": "Mouse", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor", "refseq_ac": [ { "id": "NP_080488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080488", "type": "external" } ], "gene_names_uniprotkb": "Agpat2", "gene_names_refseq": "1-AGPAT 2; 2510002J07Rik; Agpat2; BSCL1; BSCL; LPAAB; LPAAT-beta", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-AGP acyltransferase 2; 1-AGPAT 2; 1-acylglycerol-3-phosphate O-acyltransferase 2; 2.3.1.51; LPAAT-beta; Lysophosphatidic acid acyltransferase beta", "protein_names_refseq": "1-AGP acyltransferase 2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)", "tax_id": 10090, "disease": "congenital generalized lipodystrophy type 1 (Disease Ontology:DOID:0111135); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (mmu:67512); (R-MMU-1483166); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11967537;12765973;15367102;16150824;21750661;31219806;34428180;36210013;37591406", "class_list": "", "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone., [UniProtKB, PubMed]; Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr[-/-] mice., [RefSeq, PubMed]; MAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption, [RefSeq, PubMed]; There is a prevalence of mutations in this enzymes among human lipodystrophies, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0008544 epidermis development;GO:0001819 positive regulation of cytokine production;GO:0009410 response to xenobiotic stimulus;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K3K7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYY7-1", "uniprot_id": [ { "id": "PLD3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYY7", "type": "external" } ], "mass": 21492.0, "length": 195, "protein_name": "PRELI domain containing protein 3B", "gene_name": "Prelid3b", "organism": "Mouse", "refseq_name": "PRELI domain containing protein 3B", "refseq_ac": [ { "id": "NP_079807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079807", "type": "external" } ], "gene_names_uniprotkb": "Prelid3b; Slmo2", "gene_names_refseq": "2310042G06Rik; Prelid3b; Slmo2", "protein_names_uniprotkb": "PRELI domain containing protein 3B; Protein slowmo homolog 2", "protein_names_refseq": "PRELI domain containing protein 3B; likely orthologue of H. sapiens chromosome 20 open reading frame 45 (C20orf45); protein slowmo homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66390)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19892989;21750661;22872234;25428506;25605945;30084848;31219806;33649389;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADM7;Q3UC64;Q9CRD3", "ec_number_list": [], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CYY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXA1-1", "uniprot_id": [ { "id": "PLCX2_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXA1", "type": "external" } ], "mass": 38618.0, "length": 340, "protein_name": "PI-PLC X domain-containing protein 2", "gene_name": "Plcxd2", "organism": "Mouse", "refseq_name": "PI-PLC X domain-containing protein 2", "refseq_ac": [ { "id": "NP_001127952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127952", "type": "external" } ], "gene_names_uniprotkb": "Plcxd2", "gene_names_refseq": "EG433022; PLCXD-2; Plcxd2", "protein_names_uniprotkb": "PI-PLC X domain-containing protein 2; PLCXD-2; Phospholipase C X-domain containing protein 2", "protein_names_refseq": "PI-PLC X domain-containing protein 2; phospholipase C X-domain containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:433022)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;22732399;25428506;34428180", "class_list": "", "function": "Catalyzes the hydrolysis of inositol from phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI). Could also hydrolyze various multi-phosphorylated derivatives of PI, such as phosphatidylinositol-4,5 bisphosphate (PIP2), releasing inositol-1,4,5-trisphosphate (IP3) and the protein kinase C activator diacylglycerol (DAG), therefore mediating cell signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RXA1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXQ2-1", "uniprot_id": [ { "id": "PIGT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXQ2", "type": "external" } ], "mass": 65705.0, "length": 582, "protein_name": "GPI-anchor transamidase component PIGT", "gene_name": "Pigt", "organism": "Mouse", "refseq_name": "GPI-anchor transamidase component PIGT isoform 1 precursor", "refseq_ac": [ { "id": "NP_598540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598540", "type": "external" } ], "gene_names_uniprotkb": "Pigt; Ndap7", "gene_names_refseq": "2510012P17Rik; 4930534E15Rik; CGI-06; NDAP; Ndap7; Pigt", "protein_names_uniprotkb": "GPI-anchor transamidase component PIGT; Neuronal development-associated protein 7; Phosphatidylinositol-glycan biosynthesis class T protein", "protein_names_refseq": "GPI transamidase component PIG-T; GPI-anchor transamidase component PIGT isoform 1 precursor; GPI-anchor transamidase component PIGT; neuronal development-associated protein 7; phosphatidylinositol-glycan biosynthesis class T protein", "tax_id": 10090, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); multiple congenital anomalies-hypotonia-seizures syndrome 3 (Disease Ontology:DOID:0080140)", "pathway": " (mmu:78928); (R-MMU-162791)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11700951;16516892;19349973;21750661;28135057;28528544;30899004;31219806;33300544;34428180;36210013;37828378;40997131", "class_list": "glycogene", "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. May play a crucial role in GPI-T complex assembly in the luminal layer (By similarity). Binds GPI-anchor (By similarity)., [UniProtKB, UniProtKB]; Different regulations of NDAP expression by neurotrophins indicate that the expression of NDAP might be a checkpoint for apoptosis during neuronal development [NDAP], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A5G2;Q3U2X2;Q99JA3", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0030182 neuron differentiation;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BXQ2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHS4-1", "uniprot_id": [ { "id": "PLCX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHS4", "type": "external" } ], "mass": 38718.0, "length": 345, "protein_name": "PI-PLC X domain-containing protein 1", "gene_name": "Plcxd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plcxd1", "gene_names_refseq": "", "protein_names_uniprotkb": "PI-PLC X domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;22732399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYI5", "ec_number_list": [], "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CHS4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYE0-1", "uniprot_id": [ { "id": "PLAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYE0", "type": "external" } ], "mass": 55579.0, "length": 499, "protein_name": "Zinc finger protein PLAG1", "gene_name": "Plag1", "organism": "Mouse", "refseq_name": "zinc finger protein PLAG1", "refseq_ac": [ { "id": "NP_064353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064353", "type": "external" } ], "gene_names_uniprotkb": "Plag1", "gene_names_refseq": "Plag1", "protein_names_uniprotkb": "Zinc finger protein PLAG1; Pleiomorphic adenoma gene 1 protein", "protein_names_refseq": "C2H2 zinc finger protein PLAG1; pleiomorphic adenoma gene 1 protein; zinc finger protein PLAG1", "tax_id": 10090, "disease": "Silver-Russell syndrome (Disease Ontology:DOID:14681); pleomorphic adenoma (Disease Ontology:DOID:452)", "pathway": " (mmu:56711)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15044690;15585652;15606491;15930271;16108035;16193498;21750661;31464202;32959928;33346119;35820727;38240991", "class_list": "", "function": "Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis., [RefSeq, PubMed]; Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice., [RefSeq, PubMed]; Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions, [RefSeq, PubMed]; The Role of PLAG1 in Mouse Brain Development and Neurogenesis., [RefSeq, PubMed]; Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11., [UniProtKB, PubMed, PubMed, PubMed]; Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXC4;Q3UXC0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QYE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43252-1", "uniprot_id": [ { "id": "PI2R_MOUSE", "url": "https://www.uniprot.org/uniprot/P43252", "type": "external" } ], "mass": 44463.0, "length": 415, "protein_name": "Prostacyclin receptor", "gene_name": "Ptgir", "organism": "Mouse", "refseq_name": "prostacyclin receptor isoform 1", "refseq_ac": [ { "id": "NP_032993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032993", "type": "external" } ], "gene_names_uniprotkb": "Ptgir", "gene_names_refseq": "IP; PGI2; Ptgir", "protein_names_uniprotkb": "Prostacyclin receptor; PGI receptor; PGI2 receptor; Prostaglandin I2 receptor; Prostanoid IP receptor", "protein_names_refseq": "PGI receptor; PGI2 receptor; prostacyclin receptor isoform 1; prostacyclin receptor; prostaglandin I2 receptor; prostanoid IP receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:19222); (R-MMU-391908); (R-MMU-392851); (R-MMU-418555)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10446129;21750661;23457445;34101620;34428180;7511597", "class_list": "", "function": "Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase., [UniProtKB]; Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q52KE5", "ec_number_list": [], "go_molecular_function": "GO:0016501 prostacyclin receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide;GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43252-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM05-1", "uniprot_id": [ { "id": "PIAS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM05", "type": "external" } ], "mass": 55570.0, "length": 507, "protein_name": "E3 SUMO-protein ligase PIAS4", "gene_name": "Pias4", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase PIAS4", "refseq_ac": [ { "id": "NP_067476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067476", "type": "external" } ], "gene_names_uniprotkb": "Pias4; Piasg", "gene_names_refseq": "PIASY; Pias-gamma; Pias4; Piasg", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS4; 2.3.2.27; PIAS-gamma; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma", "protein_names_refseq": "E3 SUMO-protein ligase PIAS4; RING-type E3 ubiquitin transferase PIAS4; protein inhibitor of activated STAT PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein gamma", "tax_id": 10090, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:59004); (R-MMU-196791); (R-MMU-3108214); (R-MMU-3232118); (R-MMU-3232142); (R-MMU-3899300); (R-MMU-4085377); (R-MMU-4090294); (R-MMU-4615885); (R-MMU-4755510); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 14, "publication_count": 13, "publication_id_list": "10854042;11731474;12750312;16352559;16816390;21750661;25428506;27162139;27285989;27323886;28970247;30084848;34428180", "class_list": "", "function": "Findings indicate that protein inhibitor of activated STAT 4 (PIAS4) mediated SIRT1 repression in response to nutrient surplus contributes to the pathogenesis of Nonalcoholic Steatohepatitis (NASH)., [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (By similarity). Mediates sumoylation of ALKBH5, AXIN1, CEBPA, KLF8, GATA2, PARK7, HERC2, MYB, TCF4 and RNF168 (By similarity). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway (By similarity). Involved in gene silencing (By similarity). In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (PubMed:11731474). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity). Mediates sumoylation of KLF8, repressing KLF8 transcriptional activity and cell cycle progression into G(1) phase (By similarity). Sumoylates ALKBH5 downstream of MAPK8/JNK1 and MAPK9/JNK2 in response to reactive oxygen species (ROS), inhibiting ALKBH5 RNA demethylase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; PIAS4 mediated SIRT1 repression led to SMAD3 hyperacetylation and enhanced SMAD3 binding to fibrogenic gene promoters and PIAS4 promoted hepatic stellate cells activation in a SIRT1-dependent manner in vitro. Erratum:[Sci Rep. 2016 Jul 27;6:30513. doi: 10.1038/srep30513. PMID: 27461716] Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R165", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:1902174 positive regulation of keratinocyte apoptotic process;GO:0060887 limb epidermis development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JM05-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTT8-1", "uniprot_id": [ { "id": "PNMA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTT8", "type": "external" } ], "mass": 69137.0, "length": 618, "protein_name": "Paraneoplastic antigen-like protein 5", "gene_name": "Pnma5", "organism": "Mouse", "refseq_name": "paraneoplastic antigen-like protein 5", "refseq_ac": [ { "id": "NP_001093931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093931", "type": "external" } ], "gene_names_uniprotkb": "Pnma5; Kiaa1934", "gene_names_refseq": "Pnma5; mKIAA1934", "protein_names_uniprotkb": "Paraneoplastic antigen-like protein 5", "protein_names_refseq": "paraneoplastic antigen-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:385377)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19366867;21750661;29228573;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI36", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0072687 meiotic spindle", "go_biological_process": "GO:0007127 meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5DTT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2J0-1", "uniprot_id": [ { "id": "PLCD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2J0", "type": "external" } ], "mass": 88607.0, "length": 785, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3", "gene_name": "Plcd3", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 1", "refseq_ac": [ { "id": "NP_690026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690026", "type": "external" } ], "gene_names_uniprotkb": "Plcd3; Kiaa1964", "gene_names_refseq": "2610205J15Rik; Plcd3; mKIAA1964", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 3.1.4.11; PLC-delta-3; Phosphoinositide phospholipase C-delta-3; Phospholipase C-delta-3", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; PLC-delta-3; phosphoinositide phospholipase C-delta-3; phospholipase C delta 3 varioant mNab", "tax_id": 10090, "disease": "", "pathway": " (mmu:72469); (R-MMU-1855204)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16314520;18177742;19144319;21035487;21183079;21187285;21750661;22723964;24810051;25428506;31219806;34428180", "class_list": "", "function": "Double disruption of PLCd1 and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta., [RefSeq, PubMed]; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (PubMed:21187285)., [UniProtKB, PubMed, PubMed]; PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development., [RefSeq, PubMed]; PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension., [RefSeq, PubMed]; Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface., [RefSeq, PubMed]; Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 to plasma membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AHR0;A2AHR1;Q3UME8;Q69Z55;Q8BL19", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0042127 regulation of cell population proliferation;GO:0016042 lipid catabolic process;GO:0060716 labyrinthine layer blood vessel development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K2J0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53810-1", "uniprot_id": [ { "id": "PIPNA_MOUSE", "url": "https://www.uniprot.org/uniprot/P53810", "type": "external" } ], "mass": 31893.0, "length": 271, "protein_name": "Phosphatidylinositol transfer protein alpha isoform", "gene_name": "Pitpna", "organism": "Mouse", "refseq_name": "phosphatidylinositol transfer protein alpha isoform", "refseq_ac": [ { "id": "NP_032876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032876", "type": "external" } ], "gene_names_uniprotkb": "Pitpna; Pitpn", "gene_names_refseq": "Pitpna; Pitpn; vb; vibrator", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha", "protein_names_refseq": "PI-TP-alpha; Pitp alpha; phosphatidylinositol transfer protein alpha isoform; ptdIns transfer protein alpha; ptdInsTP alpha", "tax_id": 10090, "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)", "pathway": " (mmu:18738)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10801835;11980708;21750661;26740625;30042096;34428180;7654206;8049244;9182797", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:8049244). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3., [UniProtKB, UniProtKB]; These data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting alpha-granule physiology and secretion of TGF-beta1., [RefSeq, PubMed]; This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008289 lipid binding;GO:0000062 fatty-acyl-CoA binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0007409 axonogenesis;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35083-1", "uniprot_id": [ { "id": "PLCA_MOUSE", "url": "https://www.uniprot.org/uniprot/O35083", "type": "external" } ], "mass": 31709.0, "length": 285, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha", "gene_name": "Agpat1", "organism": "Mouse", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor", "refseq_ac": [ { "id": "NP_001156851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156851", "type": "external" } ], "gene_names_uniprotkb": "Agpat1", "gene_names_refseq": "1-AGPAT; 1-AGP; Agpat1", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-AGP acyltransferase 1; 1-AGPAT 1; 1-acylglycerol-3-phosphate O-acyltransferase 1; 2.3.1.51; LPAAT-alpha; Lysophosphatidic acid acyltransferase alpha", "protein_names_refseq": "1-AGP acyltransferase 1; 1-AGPAT 1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha); Lpaat-alpha; lysophosphatidic acid acyltransferase alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:55979); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14656967;15367102;20561744;21750661;28973305;33300544;34428180;9299423", "class_list": "", "function": "Agpat1-/- mice developed widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. AGPAT1 appears to serve important functions in the physiology of multiple organ systems. The Agpat1-deficient mouse provides an important model in which to study the contribution of phospholipid and triacylglycerol synthesis to physiology and diseases., [RefSeq, PubMed]; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observations strongly implicate AGPAT1 in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35446", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.121", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0001819 positive regulation of cytokine production;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35160-1", "uniprot_id": [ { "id": "PITX3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35160", "type": "external" } ], "mass": 31715.0, "length": 302, "protein_name": "Pituitary homeobox 3", "gene_name": "Pitx3", "organism": "Mouse", "refseq_name": "pituitary homeobox 3", "refseq_ac": [ { "id": "NP_032878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032878", "type": "external" } ], "gene_names_uniprotkb": "Pitx3", "gene_names_refseq": "Pitx3; Ptx3; ak; aphakia", "protein_names_uniprotkb": "Pituitary homeobox 3; Homeobox protein PITX3; Paired-like homeodomain transcription factor 3", "protein_names_refseq": "homeobox protein PITX3; pituitary homeobox 3", "tax_id": 10090, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 1 (Disease Ontology:DOID:0080606); cataract 11 multiple types (Disease Ontology:DOID:0110249); cataract 9 multiple types (Disease Ontology:DOID:0110266); Parkinson's disease (Disease Ontology:DOID:14330); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:18742)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15950611;17184956;19007884;19144721;19334279;21750661;9328475;9620774", "class_list": "", "function": "Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB03", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0014014 negative regulation of gliogenesis;GO:1904935 positive regulation of cell proliferation in midbrain;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35160-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70314-1", "uniprot_id": [ { "id": "PITX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70314", "type": "external" } ], "mass": 34075.0, "length": 315, "protein_name": "Pituitary homeobox 1", "gene_name": "Pitx1", "organism": "Mouse", "refseq_name": "pituitary homeobox 1", "refseq_ac": [ { "id": "NP_035227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035227", "type": "external" } ], "gene_names_uniprotkb": "Pitx1; Bft; Potx; Ptx1", "gene_names_refseq": "Bft; P-OTX; Pitx1; Potx; Ptx1", "protein_names_uniprotkb": "Pituitary homeobox 1; Hindlimb-expressed homeobox protein backfoot; Homeobox protein P-OTX; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1; Pituitary OTX-related factor", "protein_names_refseq": "hindlimb-expressed homeobox protein backfoot; homeobox protein P-OTX; homeobox protein PITX1; pituitary OTX-related factor; pituitary homeobox 1", "tax_id": 10090, "disease": "clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:18740)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;34428180;8675014;8755540;9070926;9226452", "class_list": "", "function": "Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Can independently activate and synergize with PIT-1 on pituitary-specific target gene promoters, thus may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. Can activate pituitary transcription of the proopiomelanocortin gene., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54742;P70427", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70314-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09101-1", "uniprot_id": [ { "id": "PIGF_MOUSE", "url": "https://www.uniprot.org/uniprot/O09101", "type": "external" } ], "mass": 24825.0, "length": 219, "protein_name": "GPI ethanolamine phosphate transferase, stabilizing subunit", "gene_name": "Pigf", "organism": "Mouse", "refseq_name": "GPI ethanolamine phosphate transferase, stabilizing subunit isoform 1", "refseq_ac": [ { "id": "NP_032864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032864", "type": "external" } ], "gene_names_uniprotkb": "Pigf", "gene_names_refseq": "Pigf", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase, stabilizing subunit; GPI ethanolamine phosphate transferase 2, stabilizing subunit; GPI ethanolamine phosphate transferase 3, stabilizing subunit; PIG-F; Phosphatidylinositol-glycan biosynthesis class F protein", "protein_names_refseq": "GPI ethanolamine phosphate transferase 2, stabilizing subunit; GPI ethanolamine phosphate transferase 3, stabilizing subunit; GPI ethanolamine phosphate transferase, stabilizing subunit isoform 1; GPI ethanolamine phosphate transferase, stabilizing subunit; PIG-F; phosphatidylinositol glycan, class F; phosphatidylinositol-glycan biosynthesis class F protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18701); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10781593;8786134", "class_list": "glycogene", "function": "Stabilizing subunit of the ethanolamine phosphate transferase 3 and ethanolamine phosphate transferase 2 complexes that sequentially transfer an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose and the second alpha-1,6-linked mannose of a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H8) (PubMed:10781593). Participates in the tenth and eleventh steps of the glycosylphosphatidylinositol-anchor biosynthesis, in association with PIGO and PIGG, respectively (PubMed:10781593)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O09101-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1P0-1", "uniprot_id": [ { "id": "PIGY_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C1P0", "type": "external" } ], "mass": 7952.0, "length": 71, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y", "gene_name": "Pigy", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit Y", "refseq_ac": [ { "id": "NP_001076001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076001", "type": "external" } ], "gene_names_uniprotkb": "Pigy; Pigyl", "gene_names_refseq": "1810008A14Rik; PIG-Y; Pigyl; Pigy", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; PIG-Y; Phosphatidylinositol-glycan biosynthesis class Y protein", "protein_names_refseq": "phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; phosphatidylinositol-glycan biosynthesis class Y protein", "tax_id": 10090, "disease": "hyperphosphatasia with impaired intellectual development syndrome 6 (Disease Ontology:DOID:0070437)", "pathway": " (mmu:66268); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30084848;34428180", "class_list": "", "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the catalytic subunit PIGA., [UniProtKB, UniProtKB]; This gene encodes a homolog of a human protein that functions in glycosylphosphatidylinositol biosynthesis. The human protein is expressed from an unusual locus that encodes two distinct proteins in upstream and downstream CDSes; however, in mouse these two proteins are expressed from distinct loci. The product of this locus is highly similar to the protein expressed from the human downstream CDS. A separate mouse locus on chromosome 6 is orthologous to the human locus and encodes a protein similar to the human protein expressed from the upstream CDS. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C1P0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15972-1", "uniprot_id": [ { "id": "PHXR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15972", "type": "external" } ], "mass": 7277.0, "length": 65, "protein_name": "Putative per-hexamer repeat protein 2", "gene_name": "Phxr2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phxr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative per-hexamer repeat protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3267239", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE22", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15972-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20918-1", "uniprot_id": [ { "id": "PLMN_MOUSE", "url": "https://www.uniprot.org/uniprot/P20918", "type": "external" } ], "mass": 90808.0, "length": 812, "protein_name": "Plasminogen", "gene_name": "Plg", "organism": "Mouse", "refseq_name": "plasminogen precursor", "refseq_ac": [ { "id": "NP_032903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032903", "type": "external" } ], "gene_names_uniprotkb": "Plg", "gene_names_refseq": "Pg; Plg", "protein_names_uniprotkb": "Plasminogen", "protein_names_refseq": "angiostatin; plasmin heavy chain A; plasmin light chain B; plasminogen precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); plasminogen deficiency type I (Disease Ontology:DOID:0111592); osteonecrosis (Disease Ontology:DOID:10159); hereditary angioedema (Disease Ontology:DOID:14735); thrombophilia (Disease Ontology:DOID:2452); Noonan syndrome (Disease Ontology:DOID:3490); conjunctivitis (Disease Ontology:DOID:6195)", "pathway": " (mmu:18815); (R-MMU-114608); (R-MMU-1592389); (R-MMU-186797); (R-MMU-75205)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12149246;2081600;26495903;26740625;30084848;34428180;37507081;38328826;38442019;38615036;39627609;39927985;7525077", "class_list": "", "function": "Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A., [UniProtKB, UniProtKB]; Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT., [RefSeq, PubMed]; Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice., [RefSeq, PubMed]; Plasminogen degrades alpha-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (By similarity). In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIS2;Q91WJ5", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0022617 extracellular matrix disassembly;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P20918-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31362-1", "uniprot_id": [ { "id": "PO2F3_MOUSE", "url": "https://www.uniprot.org/uniprot/P31362", "type": "external" } ], "mass": 46960.0, "length": 431, "protein_name": "POU domain, class 2, transcription factor 3", "gene_name": "Pou2f3", "organism": "Mouse", "refseq_name": "POU domain, class 2, transcription factor 3", "refseq_ac": [ { "id": "NP_035269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035269", "type": "external" } ], "gene_names_uniprotkb": "Pou2f3; Epoc1; Oct11; Otf-11; Otf11", "gene_names_refseq": "Epoc-1; Oct-11a; Oct11; Otf-11; Otf11; Pou2f3; Skin-1a; Skin; Skn-1a; Skn-li", "protein_names_uniprotkb": "POU domain, class 2, transcription factor 3; Epoc-1; OTF-11; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11", "protein_names_refseq": "POU domain, class 2, transcription factor 3; oct-11; octamer-binding protein 11; octamer-binding transcription factor 11", "tax_id": 10090, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": " (mmu:18988)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "8224904;8441607;9242494", "class_list": "", "function": "Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:8441607). Regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:9242494). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H3BJT4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31362-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51432-1", "uniprot_id": [ { "id": "PLCB3_MOUSE", "url": "https://www.uniprot.org/uniprot/P51432", "type": "external" } ], "mass": 139487.0, "length": 1234, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3", "gene_name": "Plcb3", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a", "refseq_ac": [ { "id": "NP_001277278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277278", "type": "external" } ], "gene_names_uniprotkb": "Plcb3", "gene_names_refseq": "Plcb3; mKIAA4098", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 3.1.4.11; PLC-beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC-beta-3; phosphoinositide phospholipase C-beta-3", "tax_id": 10090, "disease": "spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18797); (R-MMU-112043); (R-MMU-1855204); (R-MMU-399997); (R-MMU-4086398); (R-MMU-416476); (R-MMU-418217); (R-MMU-434316); (R-MMU-500657)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "21183079;21750661;22728827;28528544;29659033;30084848;34428180;37657560;37828378;38183495;38945956;9714794", "class_list": "", "function": "A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists., [RefSeq, PubMed]; Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:22728827). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (PubMed:22728827). In conjunction with OSBPL2, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle (By similarity)., [UniProtKB, UniProtKB, PubMed]; Phospholipase C-beta3 is dispensable for vascular constriction but indispensable for vascular hyperplasia., [RefSeq, PubMed]; TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIS0", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005516 calmodulin binding;GO:0005509 calcium ion binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031161 phosphatidylinositol catabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0007208 phospholipase C-activating serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P51432-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58750-1", "uniprot_id": [ { "id": "PIM3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58750", "type": "external" } ], "mass": 35970.0, "length": 326, "protein_name": "Serine/threonine-protein kinase pim-3", "gene_name": "Pim3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase pim-3", "refseq_ac": [ { "id": "NP_663453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663453", "type": "external" } ], "gene_names_uniprotkb": "Pim3", "gene_names_refseq": "Kid1; Pim3", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-3; 2.7.11.1", "protein_names_refseq": "KID-1/kinase induced by depolarization; proviral integration site 3; serine/threonine-protein kinase pim-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:223775)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15199164;16403219;17717068;21099329;21187426;29370558;31628693;36315303", "class_list": "", "function": "All three Pim kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK-293 cells Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of microRNA-124 prevents the development of acute liver failure through the upregulation of PIM-3., [RefSeq, PubMed]; PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4., [RefSeq, PubMed]; Pim-3 kinase has a novel role in the control of self-renewal of embryonic stem cells., [RefSeq, PubMed]; Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth., [UniProtKB, PubMed, PubMed, PubMed]; Study found that by promoting the phosphorylation of Stat3 Pim-3 induced the expression of Slug, Snail, and Zeb1, which enhanced epithelial-mesenchymal transition-related changes and induced melanoma migration and invasion. Exploration of the mechanism revealed that Pim-3 bound directly to Stat3 and promoted its phosphorylation. Erratum:[Cancer Biol Ther. 2025 Dec;26(1):2500190. doi: 10.1080/15384047.2025.2500190. PMID: 40367124], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007346 regulation of mitotic cell cycle;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P58750-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00286-1", "uniprot_id": [ { "id": "PIT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00286", "type": "external" } ], "mass": 32885.0, "length": 291, "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "Pou1f1", "organism": "Mouse", "refseq_name": "pituitary-specific positive transcription factor 1 isoform a", "refseq_ac": [ { "id": "NP_032875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032875", "type": "external" } ], "gene_names_uniprotkb": "Pou1f1; Pit-1; Pit1", "gene_names_refseq": "GHF-1; Hmp1; Pit-1; Pit1-rs1; Pit1; Pou1f1; dwarf; dw", "protein_names_uniprotkb": "Pituitary-specific positive transcription factor 1; GHF-1; Growth hormone factor 1; PIT-1", "protein_names_refseq": "POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); pituitary specific transcription factor 1, related sequence 1; pituitary-specific positive transcription factor 1 isoform a", "tax_id": 10090, "disease": "combined or isolated pituitary hormone deficiency 1 (Disease Ontology:DOID:0061019); pituitary gland disease (Disease Ontology:DOID:53)", "pathway": " (mmu:18736)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1561093;1977085;21745476;21750661;38169564;39227324;8407911", "class_list": "", "function": "Mouse Pit-1 w plays a role in spermatogenesis. This is the first report demonstrating the expression of Pit-1 variants arising from alternative promoters in mammals., [RefSeq, PubMed]; SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'., [UniProtKB, UniProtKB]; Transcriptional and morphological responses following distinct muscle contraction protocols for Snell dwarf (Pit1[dw/dw]) mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0021984 adenohypophysis development;GO:0060126 somatotropin secreting cell differentiation;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00286-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08EJ0-1", "uniprot_id": [ { "id": "PL8L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08EJ0", "type": "external" } ], "mass": 20115.0, "length": 177, "protein_name": "PLAC8-like protein 1", "gene_name": "Plac8l1", "organism": "Mouse", "refseq_name": "PLAC8-like protein 1", "refseq_ac": [ { "id": "NP_081348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081348", "type": "external" } ], "gene_names_uniprotkb": "Plac8l1", "gene_names_refseq": "1700009N18Rik; 1700015M15Rik; Plac8l1", "protein_names_uniprotkb": "PLAC8-like protein 1", "protein_names_refseq": "PLAC8-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69401)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAB1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08EJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LZ8-1", "uniprot_id": [ { "id": "PLPL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32LZ8", "type": "external" } ], "mass": 48480.0, "length": 432, "protein_name": "Patatin-like phospholipase domain-containing protein 5", "gene_name": "Pnpla5", "organism": "Mouse", "refseq_name": "patatin-like phospholipase domain-containing protein 5", "refseq_ac": [ { "id": "NP_083703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083703", "type": "external" } ], "gene_names_uniprotkb": "Pnpla5", "gene_names_refseq": "4833426H19Rik; GS2L; Pnpla5", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 5; 3.1.1.3", "protein_names_refseq": "patatin-like phospholipase domain-containing protein 5", "tax_id": 10090, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:75772); (R-MMU-163560)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has abundant triacylglycerol lipase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D603", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LZ8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHK5-1", "uniprot_id": [ { "id": "PLEK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHK5", "type": "external" } ], "mass": 39901.0, "length": 350, "protein_name": "Pleckstrin", "gene_name": "Plek", "organism": "Mouse", "refseq_name": "pleckstrin", "refseq_ac": [ { "id": "NP_062422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062422", "type": "external" } ], "gene_names_uniprotkb": "Plek", "gene_names_refseq": "2010300B13Rik; Plek", "protein_names_uniprotkb": "Pleckstrin", "protein_names_refseq": "pleckstrin", "tax_id": 10090, "disease": "", "pathway": " (mmu:56193); (R-MMU-114608)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10860665;19190246;21183079;21649580;21750661;26740625;31219806;31599954;34428180", "class_list": "", "function": "Major protein kinase C substrate of platelets., [UniProtKB]; Pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets, [RefSeq, PubMed]; Targeting of the pleckstrin homology domain of AKT was studied in cancer treatment in mouse models. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERI9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005080 protein kinase C binding;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0002576 platelet degranulation;GO:0007229 integrin-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JHK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9N4-1", "uniprot_id": [ { "id": "PIGH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5M9N4", "type": "external" } ], "mass": 21078.0, "length": 188, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit H", "gene_name": "Pigh", "organism": "Mouse", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 1", "refseq_ac": [ { "id": "NP_084264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084264", "type": "external" } ], "gene_names_uniprotkb": "Pigh", "gene_names_refseq": "2210416H01Rik; A930028P05Rik; PIG-H; Pigh", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; PIG-H; Phosphatidylinositol-glycan biosynthesis class H protein", "protein_names_refseq": "phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 1; phosphatidylinositol N-acetylglucosaminyltransferase subunit H; phosphatidylinositol glycan, class H; phosphatidylinositol-glycan biosynthesis class H protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:110417); (R-MMU-162710)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9N4-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SW28-1", "uniprot_id": [ { "id": "PI3R5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SW28", "type": "external" } ], "mass": 96954.0, "length": 871, "protein_name": "Phosphoinositide 3-kinase regulatory subunit 5", "gene_name": "Pik3r5", "organism": "Mouse", "refseq_name": "phosphoinositide 3-kinase regulatory subunit 5", "refseq_ac": [ { "id": "NP_796294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796294", "type": "external" } ], "gene_names_uniprotkb": "Pik3r5", "gene_names_refseq": "F730038I15Rik; Foap2; Pik3r5; p101", "protein_names_uniprotkb": "Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase p101; PtdIns-3-kinase regulatory subunit; p101-PI3K", "protein_names_refseq": "PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; p101-PI3K; phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; phosphoinositide 3-kinase regulatory subunit 5; phosphoinositide-3-kinase, regulatory subunit 5, p101; ptdIns-3-kinase p101; ptdIns-3-kinase regulatory subunit", "tax_id": 10090, "disease": "ataxia-oculomotor apraxia 3 (Disease Ontology:DOID:0060557); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:320207); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1660499); (R-MMU-389357); (R-MMU-392451); (R-MMU-6811558); (R-MMU-9027276); (R-MMU-9927354)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "21183079;33144519;34428180;36512272;37805473", "class_list": "", "function": "Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5., [RefSeq, PubMed]; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU01;Q3UDZ2;Q8C215;Q8CGQ7", "ec_number_list": [], "go_molecular_function": "GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0043406 positive regulation of MAP kinase activity;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SW28-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SX19-1", "uniprot_id": [ { "id": "PIGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SX19", "type": "external" } ], "mass": 28183.0, "length": 252, "protein_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase", "gene_name": "Pigl", "organism": "Mouse", "refseq_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1", "refseq_ac": [ { "id": "NP_001034625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034625", "type": "external" } ], "gene_names_uniprotkb": "Pigl; Gm737", "gene_names_refseq": "Gm737; Pigl", "protein_names_uniprotkb": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; 3.5.1.89; PIG-L; Phosphatidylinositol-glycan biosynthesis class L protein", "protein_names_refseq": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1; N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; ortholog of human and rat phosphatidylinositol glycan class L PIGL; phosphatidylinositol-glycan biosynthesis class L protein", "tax_id": 10090, "disease": "CHIME syndrome (Disease Ontology:DOID:0112152)", "pathway": " (mmu:327942); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29539633;31219806", "class_list": "glycogene", "function": "Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.89", "type": "external" } ], "go_molecular_function": "GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SX19-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62070-1", "uniprot_id": [ { "id": "PIM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62070", "type": "external" } ], "mass": 40060.0, "length": 370, "protein_name": "Serine/threonine-protein kinase pim-2", "gene_name": "Pim2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase pim-2", "refseq_ac": [ { "id": "NP_613072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613072", "type": "external" } ], "gene_names_uniprotkb": "Pim2; Pim-2", "gene_names_refseq": "DXCch3; Pim-2; Pim2", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-2; 2.7.11.1", "protein_names_refseq": "proviral integration site 2; serine/threonine-protein kinase pim-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18715)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12869584;12954615;15199164;15548703;15642745;15705789;17476689;18438430;21750661;35696529;36897958;37059967;38700370;7781606;9294606", "class_list": "", "function": "An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells., [RefSeq, PubMed]; Invitro transcription/translation, site-directed mutagenesis, and immunoprecipitation studies described here, show that translation initiates at three different start sites, with the two major upstream sites initiating at non-AUG (CUG) codons., [RefSeq, PubMed]; PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis., [RefSeq, PubMed]; Pim-2 regulates bone resorptive activity of osteoclasts via V-ATPase a3 isoform expression in periodontal disease., [RefSeq, PubMed]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regnase-1 D141N mutation induces CD4+ T cell-mediated lung granuloma formation via upregulation of Pim2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AER1;Q62071;Q62072;Q8R2P0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62086-1", "uniprot_id": [ { "id": "PON2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62086", "type": "external" } ], "mass": 39617.0, "length": 354, "protein_name": "Serum paraoxonase/arylesterase 2", "gene_name": "Pon2", "organism": "Mouse", "refseq_name": "serum paraoxonase/arylesterase 2", "refseq_ac": [ { "id": "NP_899131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899131", "type": "external" } ], "gene_names_uniprotkb": "Pon2", "gene_names_refseq": "6330405I24Rik; Pon2", "protein_names_uniprotkb": "Serum paraoxonase/arylesterase 2; 3.1.1.2; 3.1.1.81; A-esterase 2; Aromatic esterase 2; PON 2; Serum aryldialkylphosphatase 2", "protein_names_refseq": "A-esterase 2; aromatic esterase 2; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); familial hypercholesterolemia (Disease Ontology:DOID:13810); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:330260); (R-MMU-2142688)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12615656;15544923;15963993;30899004;31219806;34428180;37337025;38935306;8661009", "class_list": "", "function": "Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters., [UniProtKB]; FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Increased macrophage PON2 expression under oxidative stress could represent a selective cellular response to reduce oxidative burden, which may lead to attenuation of macrophage foam cell formation., [RefSeq, PubMed]; PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis, [RefSeq, PubMed]; Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD3;Q8CFK3", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.81", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004064 arylesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0009636 response to toxic substance;GO:1901335 lactone catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62086-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PD26-1", "uniprot_id": [ { "id": "PIGS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PD26", "type": "external" } ], "mass": 61711.0, "length": 555, "protein_name": "GPI-anchor transamidase component PIGS", "gene_name": "Pigs", "organism": "Mouse", "refseq_name": "GPI-anchor transamidase component PIGS isoform 1", "refseq_ac": [ { "id": "NP_958808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958808", "type": "external" } ], "gene_names_uniprotkb": "Pigs", "gene_names_refseq": "Gm393; Gm689; Pigs", "protein_names_uniprotkb": "GPI-anchor transamidase component PIGS; Phosphatidylinositol-glycan biosynthesis class S protein", "protein_names_refseq": "GPI transamidase component PIG-S; GPI-anchor transamidase component PIGS isoform 1; GPI-anchor transamidase component PIGS; phosphatidylinositol glycan, class S homolog; phosphatidylinositol-glycan biosynthesis class S protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 95 (Disease Ontology:DOID:0070382)", "pathway": " (mmu:276846); (R-MMU-162791)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19349973;30084848;30899004;31219806;34428180;40885482;40997131", "class_list": "glycogene", "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PD26-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6U7H8-1", "uniprot_id": [ { "id": "PI5L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6U7H8", "type": "external" } ], "mass": 45293.0, "length": 395, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1", "gene_name": "Pip5kl1", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_937834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937834", "type": "external" } ], "gene_names_uniprotkb": "Pip5kl1; Pipkh", "gene_names_refseq": "Pip5kl1", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; PI(4)P 5-kinase-like protein 1; PIPKH; Phosphatidylinositol phosphate kinase homolog; PtdIns(4)P-5-kinase-like protein 1", "protein_names_refseq": "PI(4)P 5-kinase-like protein 1; PIPKH; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2; phosphatidylinositol 4-phosphate 5-kinase-like protein 1; phosphatidylinositol phosphate kinase homolog; ptdIns(4)P-5-kinase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227733)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14701839", "class_list": "", "function": "Likely functions as a regulatory or scaffold-like protein that modulates the subcellular localization and activity of type I PI(4)P 5-kinases (PIPKs) (PubMed:14701839). Lacks intrinsic lipid kinase activity (PubMed:14701839)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASY7;A2ASY9;Q3TNU0;Q3V0C8;Q52KH3;Q8K345", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0030336 negative regulation of cell migration;GO:0010917 negative regulation of mitochondrial membrane potential;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6U7H8-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W71-1", "uniprot_id": [ { "id": "PKHA8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W71", "type": "external" } ], "mass": 57962.0, "length": 519, "protein_name": "Pleckstrin homology domain-containing family A member 8", "gene_name": "Plekha8", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family A member 8 isoform 2", "refseq_ac": [ { "id": "NP_001001335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001335", "type": "external" } ], "gene_names_uniprotkb": "Plekha8; Fapp2", "gene_names_refseq": "6330400G01; Fapp-2; Fapp2; Plekha8", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 8; FAPP-2; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositol 4-phosphate adapter protein 2", "protein_names_refseq": "PH domain-containing family A member 8; phosphatidylinositol-four-phosphate adapter protein 2; phosphoinositol 4-phosphate adapter protein 2; pleckstrin homology domain-containing family A member 8 isoform 2; pleckstrin homology domain-containing family A member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:231999); (R-MMU-1660499); (R-MMU-9845576)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability (By similarity). Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0097001 ceramide binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0006869 lipid transport;GO:0035621 ER to Golgi ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80W71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1C8-1", "uniprot_id": [ { "id": "PNMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1C8", "type": "external" } ], "mass": 39718.0, "length": 353, "protein_name": "Paraneoplastic antigen Ma1 homolog", "gene_name": "Pnma1", "organism": "Mouse", "refseq_name": "paraneoplastic antigen Ma1 homolog", "refseq_ac": [ { "id": "NP_081714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081714", "type": "external" } ], "gene_names_uniprotkb": "Pnma1; Ma1", "gene_names_refseq": "5730402C15Rik; Pnma1", "protein_names_uniprotkb": "Paraneoplastic antigen Ma1 homolog", "protein_names_refseq": "paraneoplastic antigen Ma1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70481)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19366867;20936693", "class_list": "", "function": "PNMA1 functions to promote neuronal death. PNMA1-mediated apoptosis can be prevented by Bcl2. Although the detailed mechanism remains to be delineated, it is likely to involve association of proteins with PNMA1 through its BH3-like sequence., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVU2;Q9CYP2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002437 inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C1C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2R7-1", "uniprot_id": [ { "id": "PIGM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2R7", "type": "external" } ], "mass": 49789.0, "length": 423, "protein_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "gene_name": "Pigm", "organism": "Mouse", "refseq_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "refseq_ac": [ { "id": "NP_080510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080510", "type": "external" } ], "gene_names_uniprotkb": "Pigm", "gene_names_refseq": "4933437L05Rik; C920011G20Rik; Pigm", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; 2.4.1.-; GPI mannosyltransferase I; GPI-MT-I; PIG-M; Phosphatidylinositol-glycan biosynthesis class M protein", "protein_names_refseq": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; PIG-M; phosphatidylinositol glycan, class M; phosphatidylinositol-glycan biosynthesis class M protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67556); (R-MMU-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30779550;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C917;Q99J22;Q9D315", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0180041 dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C2R7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C398-1", "uniprot_id": [ { "id": "PIGW_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C398", "type": "external" } ], "mass": 56841.0, "length": 503, "protein_name": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW", "gene_name": "Pigw", "organism": "Mouse", "refseq_name": "glucosaminyl-phosphatidylinositol- acyltransferase PIGW", "refseq_ac": [ { "id": "NP_001071104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071104", "type": "external" } ], "gene_names_uniprotkb": "Pigw", "gene_names_refseq": "2610044A17Rik; Gwt1; PIG-W; Pigw", "protein_names_uniprotkb": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW; 2.3.-.-; GlcN-PI-acyltransferase; PIG-W; Phosphatidylinositol-glycan biosynthesis class W protein", "protein_names_refseq": "glcN-PI-acyltransferase; glucosaminyl-phosphatidylinositol- acyltransferase PIGW; phosphatidylinositol glycan, class W; phosphatidylinositol-glycan biosynthesis class W protein", "tax_id": 10090, "disease": "hyperphosphatasia with impaired intellectual development syndrome 5 (Disease Ontology:DOID:0070432)", "pathway": " (mmu:70325); (R-MMU-162710)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21367863", "class_list": "glycogene", "function": "Acyltransferase that catalyzes the acyl transfer from an acyl-CoA at the 2-OH position of the inositol ring of a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl phosphatidylinositol, GlcN-PI) to generate a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) and participates in the fourth step of GPI-anchor biosynthesis (By similarity). Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Acylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Analysis of essential residues of PIG-W and Gwt1p and membrane topology of Gwt1p, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4S0;Q9CSX1", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C398-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K262-1", "uniprot_id": [ { "id": "PLAC9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K262", "type": "external" } ], "mass": 11275.0, "length": 108, "protein_name": "Placenta-specific protein 9", "gene_name": "Plac9", "organism": "Mouse", "refseq_name": "placenta-specific protein 9 precursor", "refseq_ac": [ { "id": "NP_997112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997112", "type": "external" } ], "gene_names_uniprotkb": "Plac9", "gene_names_refseq": "Gm10393; Gm9780; Plac9a; Plac9b; Plac9", "protein_names_uniprotkb": "Placenta-specific protein 9", "protein_names_refseq": "placenta specific 9a; placenta specific 9b; placenta-specific protein 9 precursor; placenta-specific protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:211623)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12758124;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2D9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K262-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K358-1", "uniprot_id": [ { "id": "PIGU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K358", "type": "external" } ], "mass": 49804.0, "length": 434, "protein_name": "GPI-anchor transamidase component PIGU", "gene_name": "Pigu", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pigu; Cdc91l1", "gene_names_refseq": "", "protein_names_uniprotkb": "GPI-anchor transamidase component PIGU; Cell division cycle protein 91-like 1; GPI transamidase component PIG-U; Phosphatidylinositol glycan anchor biosynthesis class U protein; Protein CDC91-like 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-162791)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22872234;25428506;30084848;31219806;34428180", "class_list": "", "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds the lipid portion of GPI-anchor. May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921E1", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0003923 GPI-anchor transamidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K358-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3Z9-1", "uniprot_id": [ { "id": "PO121_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3Z9", "type": "external" } ], "mass": 121022.0, "length": 1200, "protein_name": "Nuclear envelope pore membrane protein POM 121", "gene_name": "Pom121", "organism": "Mouse", "refseq_name": "nuclear envelope pore membrane protein POM 121", "refseq_ac": [ { "id": "NP_683734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683734", "type": "external" } ], "gene_names_uniprotkb": "Pom121; Nup121", "gene_names_refseq": "2610027A18Rik; Pom121; mKIAA0618", "protein_names_uniprotkb": "Nuclear envelope pore membrane protein POM 121; Nucleoporin Nup121; Pore membrane protein of 121 kDa", "protein_names_refseq": "nuclear envelope pore membrane protein POM 121; nucleoporin Nup121; pore membrane protein of 121 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:107939); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;17242355;20485683;21183079;22517741;25428506;25605945;27802388;29187734;30779550;31599954;33725478;34678516;34887587;35507432;35820727;36852467;39627609;40021952;40885482;40997131", "class_list": "", "function": "Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity)., [UniProtKB]; Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSH5", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q8K3Z9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCI0-1", "uniprot_id": [ { "id": "LYLAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCI0", "type": "external" } ], "mass": 63018.0, "length": 550, "protein_name": "Lysosomal leucine aminopeptidase", "gene_name": "Plbd1", "organism": "Mouse", "refseq_name": "lysosomal leucine aminopeptidase precursor", "refseq_ac": [ { "id": "NP_080082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080082", "type": "external" } ], "gene_names_uniprotkb": "Plbd1", "gene_names_refseq": "1100001H23Rik; LyLAP; Plbd1", "protein_names_uniprotkb": "Lysosomal leucine aminopeptidase; 3.4.11.-; LAMA-like protein 1; Lamina ancestor homolog 1; LyLAP; Phospholipase B domain-containing protein 1; Phospholipase B-like 1", "protein_names_refseq": "LAMA-like protein 1; lamina ancestor homolog 1; lysosomal leucine aminopeptidase precursor; lysosomal leucine aminopeptidase; phospholipase B domain-containing protein 1; putative phospholipase B-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66857); (R-MMU-1482788); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1483115)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "16170054;26495903;26740625;28011936;29187734;30084848;31219806;32152506;34428180", "class_list": "", "function": "Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0B2;Q3TA89;Q9D1S0", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEN2-1", "uniprot_id": [ { "id": "PLET1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEN2", "type": "external" } ], "mass": 25006.0, "length": 237, "protein_name": "Placenta-expressed transcript 1 protein", "gene_name": "Plet1", "organism": "Mouse", "refseq_name": "placenta-expressed transcript 1 protein precursor", "refseq_ac": [ { "id": "NP_083915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083915", "type": "external" } ], "gene_names_uniprotkb": "Plet1", "gene_names_refseq": "0610037B23Rik; 1600029D21Rik; Plet1", "protein_names_uniprotkb": "Placenta-expressed transcript 1 protein; Antigen mAgK114", "protein_names_refseq": "antigen mAgK114; placenta-expressed transcript 1 protein precursor; placenta-expressed transcript 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76509); (R-MMU-163125)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15203209;16219980;16651715;17302988;18195351;20130590;38167746", "class_list": "", "function": "Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia. Publication Status: Online-Only, [RefSeq, PubMed]; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle., [UniProtKB, PubMed]; Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q05DM2;Q9DAT1;Q9DCI0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0001953 negative regulation of cell-matrix adhesion;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPV5-1", "uniprot_id": [ { "id": "PMF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPV5", "type": "external" } ], "mass": 23121.0, "length": 202, "protein_name": "Polyamine-modulated factor 1", "gene_name": "Pmf1", "organism": "Mouse", "refseq_name": "polyamine-modulated factor 1 isoform 2", "refseq_ac": [ { "id": "NP_001297534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297534", "type": "external" } ], "gene_names_uniprotkb": "Pmf1", "gene_names_refseq": "2600009M07Rik; Pmf1", "protein_names_uniprotkb": "Polyamine-modulated factor 1; PMF-1", "protein_names_refseq": "PMF-1; polyamine-modulated factor 1 isoform 2", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); bladder carcinoma (Disease Ontology:DOID:4007)", "pathway": " (mmu:67037); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "11583586;16647090;21750661;25605945;34428180", "class_list": "", "function": "Formation of the Nrf-2/PMF-1 complex is involved in transcriptional regulation of 4E-BP1, [RefSeq, PubMed]; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity). May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCB8;Q8K237;Q924B3;Q9D6E2", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043522 leucine zipper domain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0000776 kinetochore", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPV5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CW07-1", "uniprot_id": [ { "id": "PP13G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CW07", "type": "external" } ], "mass": 37823.0, "length": 347, "protein_name": "Protein phosphatase 1 regulatory subunit 3G", "gene_name": "Ppp1r3g", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 3G", "refseq_ac": [ { "id": "NP_083904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083904", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3g", "gene_names_refseq": "1600032L17Rik; Ppp1r3g", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3G", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 3G; protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibitor subunit 3G", "tax_id": 10090, "disease": "", "pathway": " (mmu:76487)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21471512;24264575;27815211;34862394", "class_list": "", "function": "Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits., [UniProtKB, PubMed]; PPP1R3G is an important player that links glycogen metabolism to lipid metabolism in vivo., [RefSeq, PubMed]; PPP1R3G plays a critical role in postprandial glucose homeostasis and liver triglyceride metabolism via its regulation on hepatic glycogenesis., [RefSeq, PubMed]; PPP1R3G plays a major role to control postprandial glucose homeostasis during the fasting-feeding transition via its regulation on liver glycogenesis., [RefSeq, PubMed]; RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0045725 positive regulation of glycogen biosynthetic process;GO:2000467 positive regulation of glycogen (starch) synthase activity;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CW07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9W1-1", "uniprot_id": [ { "id": "CMAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9W1", "type": "external" } ], "mass": 23434.0, "length": 207, "protein_name": "Ciliary microtubule-associated protein 3", "gene_name": "Cimap3", "organism": "Mouse", "refseq_name": "ciliary microtubule-associated protein 3 isoform a", "refseq_ac": [ { "id": "NP_001186957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186957", "type": "external" } ], "gene_names_uniprotkb": "Cimap3; Pifo", "gene_names_refseq": "1700027A23Rik; Cimap3; Pifo", "protein_names_uniprotkb": "Ciliary microtubule-associated protein 3; Protein pitchfork", "protein_names_refseq": "ciliary microtubule-associated protein 3 isoform a; pitchfork; primary cilia formation; protein pitchfork", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503311)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;20643351;21606357;25080064;26901434;31010494", "class_list": "", "function": "1700027A23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner., [UniProtKB, PubMed]; Pitchfork (Pifo) associates with ciliary targeting complexes and accumulates at the basal body during cilia disassembly. Haploinsufficiency causes a unique node cilia duplication phenotype, left-right asymmetry defects, and heart failure., [RefSeq, PubMed]; Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. Publication Status: Online-Only, [RefSeq, PubMed]; The proper expression levels of Pitchfork might play a pivotal role in normal secondary palate morphogenesis., [RefSeq, PubMed]; There may be a potential correlation between Pitchfork and Kif3a that could regulate primary cilia disassembly during palate development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D9J0A0;D9J0A1;Q810M7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031267 small GTPase binding;GO:0008092 cytoskeletal protein binding;GO:0019894 kinesin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0031344 regulation of cell projection organization;GO:0033674 positive regulation of kinase activity;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D9W1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERS4-1", "uniprot_id": [ { "id": "PKHA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERS4", "type": "external" } ], "mass": 33423.0, "length": 297, "protein_name": "Pleckstrin homology domain-containing family A member 3", "gene_name": "Plekha3", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family A member 3", "refseq_ac": [ { "id": "NP_112546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112546", "type": "external" } ], "gene_names_uniprotkb": "Plekha3; Fapp1", "gene_names_refseq": "FAPP1; Plekha3", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 3; FAPP-1; PH domain-containing family A member 3; Phosphatidylinositol-four-phosphate adapter protein 1; Phosphoinositol 4-phosphate adapter protein 1", "protein_names_refseq": "FAPP-1; PH domain-containing family A member 3; phosphatidylinositol-four-phosphate adapter protein 1; phosphoinositol 4-phosphate adapter protein 1; pleckstrin homology domain-containing family A member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:83435); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11001876", "class_list": "", "function": "Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (By similarity). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (By similarity). Binds preferentially to PtdIns(4)P (By similarity). Negatively regulates APOB secretion from hepatocytes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ERS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI48-1", "uniprot_id": [ { "id": "PLAC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI48", "type": "external" } ], "mass": 12353.0, "length": 112, "protein_name": "Placenta-specific gene 8 protein", "gene_name": "Plac8", "organism": "Mouse", "refseq_name": "placenta-specific gene 8 protein", "refseq_ac": [ { "id": "NP_631937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631937", "type": "external" } ], "gene_names_uniprotkb": "Plac8", "gene_names_refseq": "C15; D5Wsu111e; Plac8", "protein_names_uniprotkb": "Placenta-specific gene 8 protein; Onzin; Protein C15", "protein_names_refseq": "onzin; placenta-specific gene 8 protein", "tax_id": 10090, "disease": "glucose intolerance (Disease Ontology:DOID:10603)", "pathway": " (mmu:231507); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12384430;34653773", "class_list": "", "function": "PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0009409 response to cold;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JI48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJQ0-1", "uniprot_id": [ { "id": "PIGB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJQ0", "type": "external" } ], "mass": 63120.0, "length": 542, "protein_name": "GPI alpha-1,2-mannosyltransferase 3", "gene_name": "Pigb", "organism": "Mouse", "refseq_name": "GPI alpha-1,2-mannosyltransferase 3", "refseq_ac": [ { "id": "NP_061377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061377", "type": "external" } ], "gene_names_uniprotkb": "Pigb", "gene_names_refseq": "Pig-b; Pigb", "protein_names_uniprotkb": "GPI alpha-1,2-mannosyltransferase 3; 2.4.1.-; GPI mannosyltransferase III; GPI-MT-III; PIG-B; Phosphatidylinositol-glycan biosynthesis class B protein", "protein_names_refseq": "GPI alpha-1,2-mannosyltransferase 3; GPI mannosyltransferase 3; GPI mannosyltransferase III; GPI-MT-III; involved in GPI-anchor biosynthesis; phosphatidylinositol glycan, class B; phosphatidylinositol-glycan biosynthesis class B protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 80 (Disease Ontology:DOID:0112216); sleeping sickness (Disease Ontology:DOID:10112)", "pathway": " (mmu:55981); (R-MMU-162710)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;34428180;8861954", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-1,2-mannosyltransferase that catalyzes the transfer of the third mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) and participates in the nineth step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). May also add the third mannose to a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) intermediate generating a 2-acyl-6-(alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H4) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U585;Q7TQ01", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0120564 dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJQ0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0T6-1", "uniprot_id": [ { "id": "PKDRE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0T6", "type": "external" } ], "mass": 241341.0, "length": 2126, "protein_name": "Polycystin family receptor for egg jelly", "gene_name": "Pkdrej", "organism": "Mouse", "refseq_name": "polycystin family receptor for egg jelly precursor", "refseq_ac": [ { "id": "NP_035235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035235", "type": "external" } ], "gene_names_uniprotkb": "Pkdrej", "gene_names_refseq": "Pkdrej", "protein_names_uniprotkb": "Polycystin family receptor for egg jelly; PKD and REJ homolog; Polycystic kidney disease and receptor for egg jelly-related protein", "protein_names_refseq": "PKD and REJ homolog; polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease and receptor for egg jelly-related protein; polycystin family receptor for egg jelly precursor; polycystin family receptor for egg jelly; receptor for egg jelly-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18766)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16261614;18562295;9949214", "class_list": "", "function": "Pkdrej controls the timing of fertilization in vivo through effects on sperm transport and exocytotic competence and is a factor in postcopulatory sexual selection., [RefSeq, PubMed]; Testis-specific protein that controls sperm transport and the timing of zona pellucida-evoked exocytosis of the sperm acrosome., [UniProtKB, PubMed]", "predicted_glycosites": 20, "predicted_n_glycosites": 18, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "F8VQF3", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0050982 detection of mechanical stimulus;GO:0060046 regulation of acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z0T6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5V5-1", "uniprot_id": [ { "id": "A0A075B5V5_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5V5", "type": "external" } ], "mass": 12931.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 1-39", "gene_name": "Ighv1-39", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-39", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-39", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5V5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5V6-1", "uniprot_id": [ { "id": "A0A075B5V6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5V6", "type": "external" } ], "mass": 10776.0, "length": 98, "protein_name": "Immunoglobulin heavy variable V1-42", "gene_name": "Ighv1-42", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-42", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V1-42", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2C0-1", "uniprot_id": [ { "id": "E9Q2C0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2C0", "type": "external" } ], "mass": 302583.0, "length": 2641, "protein_name": "Cilia and flagella associated protein 46", "gene_name": "Cfap46", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 46", "refseq_ac": [ { "id": "NP_001289475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289475", "type": "external" } ], "gene_names_uniprotkb": "Cfap46; 9330101J02Rik", "gene_names_refseq": "9330101J02Rik; Cfap46; E030019B06Rik; Gm170; Ttc40", "protein_names_uniprotkb": "Cilia and flagella associated protein 46", "protein_names_refseq": "cilia and flagella protein 46; cilia- and flagella-associated protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:212124)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30059200;40473901", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9Q2C0-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LI67-1", "uniprot_id": [ { "id": "FRPD2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LI67", "type": "external" } ], "mass": 152851.0, "length": 1392, "protein_name": "FERM and PDZ domain-containing protein 2", "gene_name": "Frmpd2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Frmpd2; Gm626", "gene_names_refseq": "", "protein_names_uniprotkb": "FERM and PDZ domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;29590622;31196628", "class_list": "", "function": "Functions as a scaffold protein and likely plays a role in N-methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic excitatory transmission (PubMed:31196628). May be involved in synapse formation in cone photoreceptor cells (PubMed:29590622). May play a role in the regulation of tight junction formation (By similarity). Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (By similarity). May pNF-kappa-Blay a role in the regulation of NOD2-mediated NF-kappa-B activation in immune response (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A140LI67-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GRI5-1", "uniprot_id": [ { "id": "A0A1B0GRI5_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GRI5", "type": "external" } ], "mass": 27328.0, "length": 255, "protein_name": "Leucine rich repeat containing 3C", "gene_name": "Lrrc3c", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 3C precursor", "refseq_ac": [ { "id": "NP_001182473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182473", "type": "external" } ], "gene_names_uniprotkb": "Lrrc3c", "gene_names_refseq": "Gm12; Lrrc3c", "protein_names_uniprotkb": "Leucine rich repeat containing 3C", "protein_names_refseq": "leucine-rich repeat-containing protein 3C precursor", "tax_id": 10090, "disease": "allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:192852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GRI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P6H7-1", "uniprot_id": [ { "id": "A0A1W2P6H7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P6H7", "type": "external" } ], "mass": 69791.0, "length": 600, "protein_name": "Predicted gene, 32687", "gene_name": "Gm32687", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC102635315 isoform 1", "refseq_ac": [ { "id": "NP_001361151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361151", "type": "external" } ], "gene_names_uniprotkb": "Gm32687", "gene_names_refseq": "Gm32687", "protein_names_uniprotkb": "Predicted gene, 32687", "protein_names_refseq": "uncharacterized protein LOC102635315 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102635315)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P6H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VJV2-1", "uniprot_id": [ { "id": "A0A1Y7VJV2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJV2", "type": "external" } ], "mass": 10704.0, "length": 120, "protein_name": "RIKEN cDNA A030014E15 gene", "gene_name": "A030014E15Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "A030014E15Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RIKEN cDNA A030014E15 gene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VJV2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A286YCU8-1", "uniprot_id": [ { "id": "A0A286YCU8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A286YCU8", "type": "external" } ], "mass": 36549.0, "length": 323, "protein_name": "Olfactory receptor", "gene_name": "Or4q3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or4q3; Olfr735", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:257909); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286YCU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8N0-1", "uniprot_id": [ { "id": "A2A8N0_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8N0", "type": "external" } ], "mass": 55047.0, "length": 476, "protein_name": "PRAME like 26", "gene_name": "Pramel26", "organism": "Mouse", "refseq_name": "oogenesin-like isoform 1", "refseq_ac": [ { "id": "NP_001005371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005371", "type": "external" } ], "gene_names_uniprotkb": "Pramel26", "gene_names_refseq": "Gm13084; Pramel26", "protein_names_uniprotkb": "PRAME like 26", "protein_names_refseq": "oogenesin-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381569)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A8N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q0F0-1", "uniprot_id": [ { "id": "E9Q0F0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q0F0", "type": "external" } ], "mass": 112265.0, "length": 1068, "protein_name": "Keratin 78", "gene_name": "Krt78", "organism": "Mouse", "refseq_name": "keratin Kb40", "refseq_ac": [ { "id": "NP_997652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997652", "type": "external" } ], "gene_names_uniprotkb": "Krt78", "gene_names_refseq": "2310030B04Rik; Kb40; Krt78", "protein_names_uniprotkb": "Keratin 78", "protein_names_refseq": "keratin Kb40", "tax_id": 10090, "disease": "", "pathway": " (mmu:332131); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;24129315;26340985;34887587", "class_list": "", "function": "K78 is strongly expressed in the basal and parabasal cell layers with decreasing intensity in the lower suprabasal cells of keratinising and non-keratinising squamous epithelia and keratinocyte cultures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q0F0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q365-1", "uniprot_id": [ { "id": "E9Q365_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q365", "type": "external" } ], "mass": 34308.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r101", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 101", "refseq_ac": [ { "id": "NP_001160308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160308", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r101", "gene_names_refseq": "100042968; Gm4135; Vmn1r101", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r101; vomeronasal 1 receptor 101", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042968)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q365-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPZ8-1", "uniprot_id": [ { "id": "F8VPZ8_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPZ8", "type": "external" } ], "mass": 34668.0, "length": 307, "protein_name": "Olfactory receptor", "gene_name": "Or51b17", "organism": "Mouse", "refseq_name": "olfactory receptor 64", "refseq_ac": [ { "id": "NP_038645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038645", "type": "external" } ], "gene_names_uniprotkb": "Or51b17; Olfr64", "gene_names_refseq": "5'[b]2; 5'beta2; MOR1-1; MOR1-2; ORL533; Olfr64; Or51b17", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6648196-6649143; olfactory receptor 64", "tax_id": 10090, "disease": "", "pathway": " (mmu:18366)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F8VPZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VQ63-1", "uniprot_id": [ { "id": "F8VQ63_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VQ63", "type": "external" } ], "mass": 36773.0, "length": 324, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r76", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor, G4", "refseq_ac": [ { "id": "NP_598966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598966", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r76", "gene_names_refseq": "V1rg4; Vmn1r76", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r76; vomeronasal 1 receptor, G4", "tax_id": 10090, "disease": "", "pathway": " (mmu:171239)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F8VQ63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VQM2-1", "uniprot_id": [ { "id": "F8VQM2_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VQM2", "type": "external" } ], "mass": 10494.0, "length": 93, "protein_name": "C-C motif chemokine ligand 26", "gene_name": "Ccl26", "organism": "Mouse", "refseq_name": "C-C motif chemokine 26 precursor", "refseq_ac": [ { "id": "NP_001013430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013430", "type": "external" } ], "gene_names_uniprotkb": "Ccl26", "gene_names_refseq": "Ccl26l; Ccl26", "protein_names_uniprotkb": "C-C motif chemokine ligand 26", "protein_names_refseq": "C-C motif chemokine 26 precursor; chemokine (C-C motif) ligand 26; eotaxin-3", "tax_id": 10090, "disease": "primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); eosinophilic esophagitis (Disease Ontology:DOID:13922); asthma (Disease Ontology:DOID:2841); Churg-Strauss syndrome (Disease Ontology:DOID:3049); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); eosinophilic gastroenteritis (Disease Ontology:DOID:4031); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); bullous pemphigoid (Disease Ontology:DOID:8506); gastroesophageal reflux disease (Disease Ontology:DOID:8534)", "pathway": " (mmu:541307)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16102831;21750661;25530546", "class_list": "", "function": "Data indicate that puerarin attenuates airway inflammation via eotaxin-3., [RefSeq, PubMed]; Distinct acidic and basic residues within CCR3 determine both receptor expression and activation by the eotaxins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding;GO:0031728 CCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0001938 positive regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F8VQM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QPX0-1", "uniprot_id": [ { "id": "J3QPX0_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QPX0", "type": "external" } ], "mass": 47508.0, "length": 416, "protein_name": "RIKEN cDNA 5730507C01 gene", "gene_name": "5730507C01Rik", "organism": "Mouse", "refseq_name": "zinc finger protein-like isoform 1", "refseq_ac": [ { "id": "NP_001188259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188259", "type": "external" } ], "gene_names_uniprotkb": "5730507C01Rik", "gene_names_refseq": "5730507C01Rik", "protein_names_uniprotkb": "RIKEN cDNA 5730507C01 gene", "protein_names_refseq": "zinc finger protein-like isoform 1", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QPX0-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6V1-1", "uniprot_id": [ { "id": "K7N6V1_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6V1", "type": "external" } ], "mass": 98060.0, "length": 857, "protein_name": "Vomeronasal 2, receptor 117", "gene_name": "Vmn2r117", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r117", "refseq_ac": [ { "id": "NP_001098051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098051", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r117", "gene_names_refseq": "EG619788; V2Rp6; Vmn2r117", "protein_names_uniprotkb": "Vomeronasal 2, receptor 117", "protein_names_refseq": "vomeronasal 2 receptor p6; vomeronasal receptor Vmn2r117", "tax_id": 10090, "disease": "", "pathway": " (mmu:619788)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6V1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N270-1", "uniprot_id": [ { "id": "L7N270_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N270", "type": "external" } ], "mass": 34602.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r123", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 123", "refseq_ac": [ { "id": "NP_001160179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160179", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r123", "gene_names_refseq": "Gm1446; Vmn1r123", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r123; vomeronasal 1 receptor 123", "tax_id": 10090, "disease": "", "pathway": " (mmu:384695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N270-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5T4-1", "uniprot_id": [ { "id": "A0A075B5T4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5T4", "type": "external" } ], "mass": 13109.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 1-4", "gene_name": "Ighv1-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5T4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YW72-1", "uniprot_id": [ { "id": "A0A0A6YW72_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YW72", "type": "external" } ], "mass": 365661.0, "length": 3346, "protein_name": "Dachsous cadherin related 2", "gene_name": "Dchs2", "organism": "Mouse", "refseq_name": "protocadherin-23", "refseq_ac": [ { "id": "NP_001344094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344094", "type": "external" } ], "gene_names_uniprotkb": "Dchs2", "gene_names_refseq": "Dchs2; EG627094; Gm417; Gm6731", "protein_names_uniprotkb": "Dachsous cadherin related 2", "protein_names_refseq": "dachsous 2; protocadherin alpha 5; protocadherin-23", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:100534287)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0072006 nephron development;GO:0043931 ossification involved in bone maturation;GO:0072137 condensed mesenchymal cell proliferation;GO:0030154 cell differentiation;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A0A6YW72-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YX66-1", "uniprot_id": [ { "id": "A0A0A6YX66_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YX66", "type": "external" } ], "mass": 13128.0, "length": 117, "protein_name": "Immunoglobulin heavy variable V1-20", "gene_name": "Ighv1-20", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-20", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V1-20", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A6YX66-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NC45-1", "uniprot_id": [ { "id": "Q5NC45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NC45", "type": "external" } ], "mass": 38404.0, "length": 344, "protein_name": "Olfactory receptor", "gene_name": "Or2av9", "organism": "Mouse", "refseq_name": "olfactory receptor 332", "refseq_ac": [ { "id": "NP_001011770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011770", "type": "external" } ], "gene_names_uniprotkb": "Or2av9; Olfr332", "gene_names_refseq": "MOR284-2; Olfr332; Or2av9", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2NKPP-926908-927915; olfactory receptor 332; olfactory receptor MOR284-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:257932)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5NC45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PUT0-1", "uniprot_id": [ { "id": "E9PUT0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PUT0", "type": "external" } ], "mass": 53739.0, "length": 460, "protein_name": "Zinc finger protein 983", "gene_name": "Zfp983", "organism": "Mouse", "refseq_name": "zinc finger protein 983", "refseq_ac": [ { "id": "NP_001159969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159969", "type": "external" } ], "gene_names_uniprotkb": "Zfp983", "gene_names_refseq": "3110052M02Rik; Zfp983; mszf57; mszf71", "protein_names_uniprotkb": "Zinc finger protein 983", "protein_names_refseq": "zinc finger protein 983", "tax_id": 10090, "disease": "", "pathway": " (mmu:73229)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5X2-1", "uniprot_id": [ { "id": "A0A075B5X2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5X2", "type": "external" } ], "mass": 12900.0, "length": 117, "protein_name": "Immunoglobulin heavy variable V1-63", "gene_name": "Ighv1-63", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-63", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V1-63", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WRH8-1", "uniprot_id": [ { "id": "A0A087WRH8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WRH8", "type": "external" } ], "mass": 33836.0, "length": 301, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Gm5157", "organism": "Mouse", "refseq_name": "sperm motility kinase X-like", "refseq_ac": [ { "id": "XP_011249060", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249060", "type": "external" } ], "gene_names_uniprotkb": "Gm5157", "gene_names_refseq": "Gm5157", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "sperm motility kinase X-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:381937)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WRH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JE99-1", "uniprot_id": [ { "id": "A0A0G2JE99_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JE99", "type": "external" } ], "mass": 11686.0, "length": 106, "protein_name": "Immunoglobulin lambda constant 1", "gene_name": "Iglc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Iglc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin lambda constant 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0019815 B cell receptor complex;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JE99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0R4J1Z0-1", "uniprot_id": [ { "id": "A0A0R4J1Z0_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0R4J1Z0", "type": "external" } ], "mass": 37011.0, "length": 331, "protein_name": "MAS-related GPR, member A2A", "gene_name": "Mrgpra2a", "organism": "Mouse", "refseq_name": "MAS-related GPR, member A2A isoform 2", "refseq_ac": [ { "id": "NP_001166059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166059", "type": "external" } ], "gene_names_uniprotkb": "Mrgpra2a", "gene_names_refseq": "Mrga2; Mrgpra2a; Mrgpra2", "protein_names_uniprotkb": "MAS-related GPR, member A2A", "protein_names_refseq": "MAS-related GPR, member A2A isoform 2; Mas-related G-protein coupled receptor member A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:668727)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35882236", "class_list": "", "function": "Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4J1Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0U1RQ84-1", "uniprot_id": [ { "id": "A0A0U1RQ84_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0U1RQ84", "type": "external" } ], "mass": 77955.0, "length": 676, "protein_name": "Zinc finger protein 626", "gene_name": "Zfp626", "organism": "Mouse", "refseq_name": "zinc finger protein 626", "refseq_ac": [ { "id": "NP_081979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081979", "type": "external" } ], "gene_names_uniprotkb": "Zfp626", "gene_names_refseq": "4833408D11Rik; 4933426I21Rik; 7630402I04Rik; Zfp626", "protein_names_uniprotkb": "Zinc finger protein 626", "protein_names_refseq": "zinc finger protein 626", "tax_id": 10090, "disease": "", "pathway": " (mmu:71163)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0U1RQ84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LHS7-1", "uniprot_id": [ { "id": "A0A140LHS7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LHS7", "type": "external" } ], "mass": 38528.0, "length": 346, "protein_name": "Olfactory receptor", "gene_name": "Or5bb10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or5bb10; Olfr1432", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LHS7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GS71-1", "uniprot_id": [ { "id": "A0A1B0GS71_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GS71", "type": "external" } ], "mass": 25039.0, "length": 263, "protein_name": "Keratin associated protein 5-25", "gene_name": "Krtap5-25", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC115486481", "refseq_ac": [ { "id": "NP_001365628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365628", "type": "external" } ], "gene_names_uniprotkb": "Krtap5-25; Gm45337", "gene_names_refseq": "Gm45337; Krtap5-25", "protein_names_uniprotkb": "Keratin associated protein 5-25", "protein_names_refseq": "uncharacterized protein LOC115486481", "tax_id": 10090, "disease": "", "pathway": " (mmu:115486481); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GS71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VIM3-1", "uniprot_id": [ { "id": "A0A1Y7VIM3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIM3", "type": "external" } ], "mass": 11873.0, "length": 128, "protein_name": "RIKEN cDNA A030003K21 gene", "gene_name": "A030003K21Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "A030003K21Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RIKEN cDNA A030003K21 gene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VIM3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VJE9-1", "uniprot_id": [ { "id": "A0A1Y7VJE9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJE9", "type": "external" } ], "mass": 16598.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad13", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 1A domain containing 13", "refseq_ac": [ { "id": "NP_001423236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423236", "type": "external" } ], "gene_names_uniprotkb": "Eif1ad13", "gene_names_refseq": "Eif1ad13; Gm21936", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4C", "protein_names_refseq": "eukaryotic translation initiation factor 1A domain containing 13", "tax_id": 10090, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:100861898)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VJE9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MV1-1", "uniprot_id": [ { "id": "TDRD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MV1", "type": "external" } ], "mass": 129696.0, "length": 1172, "protein_name": "Tudor domain-containing protein 1", "gene_name": "Tdrd1", "organism": "Mouse", "refseq_name": "tudor domain-containing protein 1", "refseq_ac": [ { "id": "NP_001002238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002238", "type": "external" } ], "gene_names_uniprotkb": "Tdrd1", "gene_names_refseq": "MTR-1; Tdrd1", "protein_names_uniprotkb": "Tudor domain-containing protein 1", "protein_names_refseq": "tudor domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83561)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11279525;14550528;16787967;17038506;17141210;19345100;19465913;19584108;20439430;22996915;24067652;35820727", "class_list": "", "function": "Isolated Mouse tudor repeat-1 (Mtr-1) which encodes a MYND domain and four copies of the tudor domain. Mtr-1 is expressed in germ-line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes., [RefSeq, PubMed]; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins., [UniProtKB, PubMed, PubMed, PubMed]; Targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male sterility because of postnatal spermatogenic defects, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2VDG6;Q6F3G0;Q8CDN7;Q8K1G3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex;GO:0071546 pi-body", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0034587 piRNA processing;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99MV1-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A9H6-1", "uniprot_id": [ { "id": "A2A9H6_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A9H6", "type": "external" } ], "mass": 405695.0, "length": 3643, "protein_name": "Leucine rich repeat containing 37", "gene_name": "Lrrc37", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrrc37", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine rich repeat containing 37", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:380730)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2A9H6-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4F2-1", "uniprot_id": [ { "id": "KLH18_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4F2", "type": "external" } ], "mass": 63686.0, "length": 574, "protein_name": "Kelch-like protein 18", "gene_name": "Klhl18", "organism": "Mouse", "refseq_name": "kelch-like protein 18 isoform 1", "refseq_ac": [ { "id": "NP_808439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808439", "type": "external" } ], "gene_names_uniprotkb": "Klhl18", "gene_names_refseq": "A930041K15; Klhl18", "protein_names_uniprotkb": "Kelch-like protein 18", "protein_names_refseq": "kelch-like protein 18 isoform 1; kelch-like protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:270201)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31696965;34597341", "class_list": "", "function": "Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (PubMed:31696965). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (PubMed:31696965). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (PubMed:31696965)., [UniProtKB, PubMed, UniProtKB]; Suggest that Cul3-Klhl18 modulates rod Talpha translocation during light/dark adaptation through Unc119 ubiquitination, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:1901992 positive regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q4F2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PWW6-1", "uniprot_id": [ { "id": "E9PWW6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWW6", "type": "external" } ], "mass": 110793.0, "length": 970, "protein_name": "Zinc finger CCCH type containing 7 A", "gene_name": "Zc3h7a", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 7A", "refseq_ac": [ { "id": "NP_666043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666043", "type": "external" } ], "gene_names_uniprotkb": "Zc3h7a", "gene_names_refseq": "A430104C18Rik; HSPC055; Zc3h7a; Zc3h7; Zc3hdc7", "protein_names_uniprotkb": "Zinc finger CCCH type containing 7 A", "protein_names_refseq": "zinc finger CCCH domain-containing protein 7A; zinc finger CCCH type domain containing 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:106205)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0035196 miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PWW6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PX68-1", "uniprot_id": [ { "id": "E9PX68_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PX68", "type": "external" } ], "mass": 82887.0, "length": 744, "protein_name": "Solute carrier family 4 (anion exchanger), member 1, adaptor protein", "gene_name": "Slc4a1ap", "organism": "Mouse", "refseq_name": "kanadaptin isoform 1", "refseq_ac": [ { "id": "NP_001334257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334257", "type": "external" } ], "gene_names_uniprotkb": "Slc4a1ap", "gene_names_refseq": "Slc4a1ap; kanadaptin", "protein_names_uniprotkb": "Solute carrier family 4 (anion exchanger), member 1, adaptor protein", "protein_names_refseq": "kanadaptin isoform 1; solute carrier family 4 (anion exchanger), member 1, adapter protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20534)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15345747;17242355;21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9PX68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5Z9-1", "uniprot_id": [ { "id": "E9Q5Z9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5Z9", "type": "external" } ], "mass": 41666.0, "length": 360, "protein_name": "Myb/SANT DNA binding domain containing 5 family member 2", "gene_name": "Msantd5f2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Msantd5f2", "gene_names_refseq": "", "protein_names_uniprotkb": "Myb/SANT DNA binding domain containing 5 family member 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q5Z9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5Q3-1", "uniprot_id": [ { "id": "A0A075B5Q3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5Q3", "type": "external" } ], "mass": 12557.0, "length": 115, "protein_name": "Immunoglobulin heavy variable 2-5", "gene_name": "Ighv2-5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv2-5", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 2-5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5Q3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A7W0-1", "uniprot_id": [ { "id": "A2A7W0_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A7W0", "type": "external" } ], "mass": 33761.0, "length": 305, "protein_name": "CD300 molecule like family member D2", "gene_name": "Cd300ld2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd300ld2; Gm11709", "gene_names_refseq": "", "protein_names_uniprotkb": "CD300 molecule like family member D2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-198933)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002757 immune response-activating signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A7W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV26-1", "uniprot_id": [ { "id": "E9PV26_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV26", "type": "external" } ], "mass": 110692.0, "length": 1098, "protein_name": "Proline rich 36", "gene_name": "Prr36", "organism": "Mouse", "refseq_name": "proline-rich protein 36", "refseq_ac": [ { "id": "NP_997086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997086", "type": "external" } ], "gene_names_uniprotkb": "Prr36; BC068157", "gene_names_refseq": "Prr36", "protein_names_uniprotkb": "Proline rich 36", "protein_names_refseq": "proline-rich protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:73072)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17114649;21750661;22645316;24129315;34678516", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "E9PV26-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YXN8-1", "uniprot_id": [ { "id": "A0A0A6YXN8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YXN8", "type": "external" } ], "mass": 43910.0, "length": 397, "protein_name": "Tyrosine-protein phosphatase non-receptor type substrate 1", "gene_name": "Sirpb1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sirpb1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Signal-regulatory protein alpha-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0032675 regulation of interleukin-6 production;GO:0050765 negative regulation of phagocytosis;GO:0032680 regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0A6YXN8-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UZN6-1", "uniprot_id": [ { "id": "G3UZN6_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UZN6", "type": "external" } ], "mass": 40303.0, "length": 359, "protein_name": "Abhydrolase domain containing 12B", "gene_name": "Abhd12b", "organism": "Mouse", "refseq_name": "protein ABHD12B", "refseq_ac": [ { "id": "NP_001181962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181962", "type": "external" } ], "gene_names_uniprotkb": "Abhd12b", "gene_names_refseq": "Abhd12b; Gm804", "protein_names_uniprotkb": "Abhydrolase domain containing 12B", "protein_names_refseq": "protein ABHD12B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504285)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UZN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A7B5-1", "uniprot_id": [ { "id": "A2A7B5_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A7B5", "type": "external" } ], "mass": 187203.0, "length": 1709, "protein_name": "PR domain zinc finger protein 2", "gene_name": "Prdm2", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 2 isoform a", "refseq_ac": [ { "id": "NP_001074824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824", "type": "external" } ], "gene_names_uniprotkb": "Prdm2", "gene_names_refseq": "4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; KMT8; Prdm2; Riz1; Riz; Znfpr1c1", "protein_names_uniprotkb": "PR domain zinc finger protein 2; 2.1.1.355; PR domain-containing protein 2; Retinoblastoma protein-interacting zinc finger protein; Zinc finger protein RIZ", "protein_names_refseq": "PR domain zinc finger protein 2 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:110593)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15282304;17242355;20557878;21750661;26709097", "class_list": "", "function": "Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator., [RefSeq, PubMed]; Prevents lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation, [RefSeq, PubMed]; RIZ1 is an important regulator of both Akt3 transcription and AKT phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT pathway, [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2A7B5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QAE1-1", "uniprot_id": [ { "id": "E9QAE1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QAE1", "type": "external" } ], "mass": 209078.0, "length": 1909, "protein_name": "NCK-associated protein 5", "gene_name": "Nckap5", "organism": "Mouse", "refseq_name": "nck-associated protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001075225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075225", "type": "external" } ], "gene_names_uniprotkb": "Nckap5", "gene_names_refseq": "8430408F21; D130011D22Rik; E030049G20Rik; Erih1; Erih2; Gm1548; Nap5; Nckap5", "protein_names_uniprotkb": "NCK-associated protein 5", "protein_names_refseq": "nck-associated protein 5 isoform 1; peripheral clock protein", "tax_id": 10090, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:210356)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30059200", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0035371 microtubule plus-end", "go_biological_process": "GO:0007019 microtubule depolymerization;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9QAE1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5S1-1", "uniprot_id": [ { "id": "A0A075B5S1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5S1", "type": "external" } ], "mass": 11090.0, "length": 98, "protein_name": "Immunoglobulin heavy variable 9-1", "gene_name": "Ighv9-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv9-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 9-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5S1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8B5-1", "uniprot_id": [ { "id": "E9Q8B5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8B5", "type": "external" } ], "mass": 99438.0, "length": 879, "protein_name": "Complement factor H-related 4", "gene_name": "Cfhr4", "organism": "Mouse", "refseq_name": "complement factor H-related protein C isoform 1 precursor", "refseq_ac": [ { "id": "NP_001025148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025148", "type": "external" } ], "gene_names_uniprotkb": "Cfhr4; Gm4788", "gene_names_refseq": "Cfhr4; Cfhrc; EG214403; Gm4788", "protein_names_uniprotkb": "Complement factor H-related 4", "protein_names_refseq": "complement factor H-related protein C isoform 1 precursor; complement factor H-related protein C", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); basal laminar drusen (Disease Ontology:DOID:0060746); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); age related macular degeneration 4 (Disease Ontology:DOID:0110017); membranous glomerulonephritis (Disease Ontology:DOID:10976); sarcoidosis (Disease Ontology:DOID:11335); panuveitis (Disease Ontology:DOID:12030); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); posterior uveitis (Disease Ontology:DOID:12574); cardiovascular system disease (Disease Ontology:DOID:1287); obstructive jaundice (Disease Ontology:DOID:13603); anterior uveitis (Disease Ontology:DOID:1407); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); nephrosis (Disease Ontology:DOID:2527); retinal drusen (Disease Ontology:DOID:2569); brain infarction (Disease Ontology:DOID:3454); macular degeneration (Disease Ontology:DOID:4448); retinal detachment (Disease Ontology:DOID:5327); proteinuria (Disease Ontology:DOID:576); amphetamine abuse (Disease Ontology:DOID:670); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:214403)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:1905370 serine-type endopeptidase complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0007596 blood coagulation;GO:0006508 proteolysis;GO:0030449 regulation of complement activation;GO:0006956 complement activation;GO:0030451 regulation of complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q8B5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7B5D6-1", "uniprot_id": [ { "id": "F7B5D6_MOUSE", "url": "https://www.uniprot.org/uniprot/F7B5D6", "type": "external" } ], "mass": 19479.0, "length": 176, "protein_name": "Neuropeptide W", "gene_name": "Npw", "organism": "Mouse", "refseq_name": "neuropeptide W preproprotein", "refseq_ac": [ { "id": "NP_001093134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093134", "type": "external" } ], "gene_names_uniprotkb": "Npw", "gene_names_refseq": "Gm935; Npw", "protein_names_uniprotkb": "Neuropeptide W", "protein_names_refseq": "neuropeptide W preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:381073); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12719537;20189998;21750661;23927541;25270269;26209028;27140610;28249734;30609248", "class_list": "", "function": "A non-AUG translation initiation site is used to express the mouse Npw preproprotein, [RefSeq, PubMed]; Neuropeptide W modulates gastric vagal afferent activity, [RefSeq, PubMed]; Orthologs of this gene express a preproprotein that is processed into a neuropeptide ligand for two G-protein coupled receptors in the central nervous system. The neuropeptide is thought to directly or indirectly regulate feeding, weight regulation, and pain response. The preproprotein is translated using a non-AUG initiation codon. [provided by RefSeq, Jul 2008]., [RefSeq]; Study indicates that NPW may play an important role in the regulation of feeding and energy metabolism., [RefSeq, PubMed]; The effect and underlying mechanisms of NGF/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported., [RefSeq, PubMed]; The neuropeptide W (NPW) mRNA quickly elevated in the early differentiation (7-14 days) of ATDC5 cells, while NPW and neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the late stage (14-21 days) of differentiation., [RefSeq, PubMed]; These findings suggest that the physiological role of NPW varies depending on the age of the mice., [RefSeq, PubMed]; These results indicate that the NPW/NPBWR1 system could play a critical role in the gating of stressful stimuli during exposure to novel environments., [RefSeq, PubMed]; These studies indicated an inconsistency between plasma and gastric NPW expression in response to nutrient ingestion, suggesting food induced gastric NPW expression may play a more important role locally, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F7B5D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8A4-1", "uniprot_id": [ { "id": "E9Q8A4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8A4", "type": "external" } ], "mass": 54308.0, "length": 466, "protein_name": "F-box and WD-40 domain protein 28", "gene_name": "Fbxw28", "organism": "Mouse", "refseq_name": "F-box and WD-40 domain protein 28 isoform 2", "refseq_ac": [ { "id": "NP_001170891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170891", "type": "external" } ], "gene_names_uniprotkb": "Fbxw28", "gene_names_refseq": "668758; Fbxw28; Gm9337", "protein_names_uniprotkb": "F-box and WD-40 domain protein 28", "protein_names_refseq": "F-box and WD-40 domain protein 28 isoform 2", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q8A4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z2T8-1", "uniprot_id": [ { "id": "D3Z2T8_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z2T8", "type": "external" } ], "mass": 43959.0, "length": 383, "protein_name": "Zinc finger protein 963", "gene_name": "Zfp963", "organism": "Mouse", "refseq_name": "zinc finger protein 669-like", "refseq_ac": [ { "id": "NP_001186952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186952", "type": "external" } ], "gene_names_uniprotkb": "Zfp963", "gene_names_refseq": "Zfp963", "protein_names_uniprotkb": "Zinc finger protein 963", "protein_names_refseq": "zinc finger protein 669-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:620419); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z2T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5Y8-1", "uniprot_id": [ { "id": "D3Z5Y8_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5Y8", "type": "external" } ], "mass": 64428.0, "length": 553, "protein_name": "Predicted gene 15446", "gene_name": "Gm15446", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm15446", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 15446", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z5Y8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PUN6-1", "uniprot_id": [ { "id": "E9PUN6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PUN6", "type": "external" } ], "mass": 215753.0, "length": 1931, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 9", "gene_name": "Adamts9", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adamts9", "gene_names_refseq": "", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 9", "protein_names_refseq": "", "tax_id": 10090, "disease": "scoliosis (Disease Ontology:DOID:0060249); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:101401); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0009617 response to bacterium;GO:0048593 camera-type eye morphogenesis;GO:0045636 positive regulation of melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUN6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVZ2-1", "uniprot_id": [ { "id": "E9PVZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVZ2", "type": "external" } ], "mass": 10207.0, "length": 95, "protein_name": "Transmembrane protein 273", "gene_name": "Tmem273", "organism": "Mouse", "refseq_name": "transmembrane protein 273 precursor", "refseq_ac": [ { "id": "NP_001157088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157088", "type": "external" } ], "gene_names_uniprotkb": "Tmem273", "gene_names_refseq": "1810011H11Rik; 4733401I05Rik; Tmem273", "protein_names_uniprotkb": "Transmembrane protein 273", "protein_names_refseq": "transmembrane protein 273 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69069)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PVZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PY60-1", "uniprot_id": [ { "id": "E9PY60_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PY60", "type": "external" } ], "mass": 35299.0, "length": 306, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r77", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 77", "refseq_ac": [ { "id": "NP_001160203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160203", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r77; Vmn1r78", "gene_names_refseq": "628946; Gm6935; Vmn1r77", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r77; vomeronasal 1 receptor 77", "tax_id": 10090, "disease": "", "pathway": " (mmu:628946)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PY60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYK6-1", "uniprot_id": [ { "id": "E9PYK6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYK6", "type": "external" } ], "mass": 35211.0, "length": 323, "protein_name": "Olfactory receptor", "gene_name": "Or9s14", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or9s14; Olfr1410", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258484)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYW5-1", "uniprot_id": [ { "id": "E9PYW5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYW5", "type": "external" } ], "mass": 35249.0, "length": 313, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r174", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor, D22", "refseq_ac": [ { "id": "NP_997431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997431", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r174", "gene_names_refseq": "V1rd22; Vmn1r174", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r174; vomeronasal 1 receptor, D22", "tax_id": 10090, "disease": "", "pathway": " (mmu:404291)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1Z0-1", "uniprot_id": [ { "id": "E9Q1Z0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1Z0", "type": "external" } ], "mass": 58224.0, "length": 538, "protein_name": "Keratin 90", "gene_name": "Krt90", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC239673", "refseq_ac": [ { "id": "NP_808385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808385", "type": "external" } ], "gene_names_uniprotkb": "Krt90; 4732456N10Rik", "gene_names_refseq": "4732456N10Rik; Ket90; Krt90", "protein_names_uniprotkb": "Keratin 90", "protein_names_refseq": "uncharacterized protein LOC239673", "tax_id": 10090, "disease": "", "pathway": " (mmu:239673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34887587", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q1Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q564-1", "uniprot_id": [ { "id": "E9Q564_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q564", "type": "external" } ], "mass": 35569.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or52ae7", "organism": "Mouse", "refseq_name": "olfactory receptor 608", "refseq_ac": [ { "id": "NP_666967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666967", "type": "external" } ], "gene_names_uniprotkb": "Or52ae7; Olfr608", "gene_names_refseq": "MOR26-3; Olfr608; Or52ae7", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6191595-6192545; olfactory receptor 608; olfactory receptor MOR26-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258751)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q564-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8T0-1", "uniprot_id": [ { "id": "E9Q8T0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8T0", "type": "external" } ], "mass": 36038.0, "length": 311, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r7", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 7", "refseq_ac": [ { "id": "NP_001160182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160182", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r7", "gene_names_refseq": "EG434016; Gm5568; V1rc31; Vmn1r7", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r7; vomeronasal 1 receptor 7; vomeronasal 1 receptor, C31", "tax_id": 10090, "disease": "", "pathway": " (mmu:434016)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q8T0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9G1-1", "uniprot_id": [ { "id": "E9Q9G1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9G1", "type": "external" } ], "mass": 22465.0, "length": 206, "protein_name": "U8 snoRNA-decapping enzyme", "gene_name": "Nudt16l2", "organism": "Mouse", "refseq_name": "U8 snoRNA-decapping enzyme-like", "refseq_ac": [ { "id": "NP_082838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082838", "type": "external" } ], "gene_names_uniprotkb": "Nudt16l2; 1700080E11Rik", "gene_names_refseq": "1700080E11Rik; Nudt16l2; Tseg8", "protein_names_uniprotkb": "U8 snoRNA-decapping enzyme; 3.6.1.62; 3.6.1.64; IDP phosphatase; Inosine diphosphate phosphatase; Nucleoside diphosphate-linked moiety X motif 16; m7GpppN-mRNA hydrolase", "protein_names_refseq": "U8 snoRNA-decapping enzyme-like; nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 2; nudix motif 16-like; testis specific expressed protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:73532)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "3.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.17", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0030515 snoRNA binding;GO:1990174 phosphodiesterase decapping endonuclease activity;GO:1990003 IDP phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0006402 mRNA catabolic process;GO:0016077 sno(s)RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7CWV4-1", "uniprot_id": [ { "id": "F7CWV4_MOUSE", "url": "https://www.uniprot.org/uniprot/F7CWV4", "type": "external" } ], "mass": 37083.0, "length": 335, "protein_name": "Olfactory receptor", "gene_name": "Or14a256", "organism": "Mouse", "refseq_name": "olfactory receptor 294", "refseq_ac": [ { "id": "NP_001011750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011750", "type": "external" } ], "gene_names_uniprotkb": "Or14a256; Olfr294; Olfr304", "gene_names_refseq": "MOR219-5; Olfr294; Or14a256", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2NHDJ-9504525-9505532; olfactory receptor 294; olfactory receptor MOR219-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:257904)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7CWV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPX2-1", "uniprot_id": [ { "id": "F8VPX2_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPX2", "type": "external" } ], "mass": 50534.0, "length": 458, "protein_name": "F-box/WD repeat-containing protein 9", "gene_name": "Fbxw9", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 9", "refseq_ac": [ { "id": "NP_081067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081067", "type": "external" } ], "gene_names_uniprotkb": "Fbxw9", "gene_names_refseq": "1110017H11Rik; Fbw9; Fbxw9", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 9; F-box and WD-40 domain-containing protein 9", "protein_names_refseq": "F-box/WD repeat-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:68628); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15345747;21750661", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F8VPX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "I7HIK1-1", "uniprot_id": [ { "id": "I7HIK1_MOUSE", "url": "https://www.uniprot.org/uniprot/I7HIK1", "type": "external" } ], "mass": 34484.0, "length": 302, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r204", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 204", "refseq_ac": [ { "id": "NP_001039009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039009", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r204", "gene_names_refseq": "Gm11301; Vmn1r204", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r204; vomeronasal 1 receptor 204", "tax_id": 10090, "disease": "", "pathway": " (mmu:632793)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Putative pheromone receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "I7HIK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QN14-1", "uniprot_id": [ { "id": "J3QN14_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QN14", "type": "external" } ], "mass": 116002.0, "length": 987, "protein_name": "Zinc finger protein 616", "gene_name": "Zfp616", "organism": "Mouse", "refseq_name": "zinc finger protein 616", "refseq_ac": [ { "id": "NP_001171041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171041", "type": "external" } ], "gene_names_uniprotkb": "Zfp616", "gene_names_refseq": "Gm12330; Zfp616", "protein_names_uniprotkb": "Zinc finger protein 616", "protein_names_refseq": "KRAB box containing protein; novel KRAB box containing protein; zinc finger protein 616", "tax_id": 10090, "disease": "", "pathway": " (mmu:327963)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "J3QN14-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7MU59-1", "uniprot_id": [ { "id": "L7MU59_MOUSE", "url": "https://www.uniprot.org/uniprot/L7MU59", "type": "external" } ], "mass": 35348.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or8k21", "organism": "Mouse", "refseq_name": "olfactory receptor 1053", "refseq_ac": [ { "id": "NP_001171328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171328", "type": "external" } ], "gene_names_uniprotkb": "Or8k21; Olfr1053", "gene_names_refseq": "MOR187-4; Olfr1053-ps1; Olfr1053; Or8k21", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-47793414-47792471; olfactory receptor 1053, pseudogene 1; olfactory receptor 1053; olfactory receptor MOR187-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:257974)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7MU59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7MUB9-1", "uniprot_id": [ { "id": "L7MUB9_MOUSE", "url": "https://www.uniprot.org/uniprot/L7MUB9", "type": "external" } ], "mass": 21033.0, "length": 191, "protein_name": "Reproductive homeobox 2G", "gene_name": "Rhox2g", "organism": "Mouse", "refseq_name": "reproductive homeobox 2G", "refseq_ac": [ { "id": "NP_001107625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107625", "type": "external" } ], "gene_names_uniprotkb": "Rhox2g", "gene_names_refseq": "EG434766; Rhox2.7; Rhox2f; Rhox2g", "protein_names_uniprotkb": "Reproductive homeobox 2G", "protein_names_refseq": "reproductive homeobox 2F; reproductive homeobox 2G", "tax_id": 10090, "disease": "", "pathway": " (mmu:434766)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7MUB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SZ93-1", "uniprot_id": [ { "id": "NPT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SZ93", "type": "external" } ], "mass": 46377.0, "length": 420, "protein_name": "Sodium-dependent phosphate transport protein 4", "gene_name": "Slc17a3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc17a3; NPT4", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 4; NPT4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "gout (Disease Ontology:DOID:13189)", "pathway": " (mmu:105355)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38641061", "class_list": "", "function": "Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule. Mediates the renal excretion of uric acid and the uremic toxin 3-indoxyl sulfate., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3UWD9;G5E894;Q5SZ92;Q8VCY5", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0019534 toxin transmembrane transporter activity;GO:0015562 efflux transmembrane transporter activity;GO:0008308 voltage-gated monoatomic anion channel activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0046415 urate metabolic process;GO:0015711 organic anion transport;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport;GO:0015747 urate transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SZ93-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5Z8-1", "uniprot_id": [ { "id": "A0A075B5Z8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5Z8", "type": "external" } ], "mass": 12575.0, "length": 112, "protein_name": "T cell receptor alpha variable 6-1", "gene_name": "Trav6-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav6-1", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 6-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5Z8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WPP3-1", "uniprot_id": [ { "id": "A0A087WPP3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WPP3", "type": "external" } ], "mass": 25606.0, "length": 222, "protein_name": "Predicted gene, 20820", "gene_name": "Gm20820", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm20820", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 20820", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WPP3-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q007-1", "uniprot_id": [ { "id": "E9Q007_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q007", "type": "external" } ], "mass": 41709.0, "length": 373, "protein_name": "Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9", "gene_name": "Hsd3b9", "organism": "Mouse", "refseq_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b4", "refseq_ac": [ { "id": "NP_001357799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357799", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b9; Gm4450", "gene_names_refseq": "100043461; Gm4450; Hsd3b9", "protein_names_uniprotkb": "Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9", "protein_names_refseq": "NADPH-dependent 3-keto-steroid reductase Hsd3b4; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (mmu:100043461); (R-MMU-193048); (R-MMU-193993); (R-MMU-194002)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q007-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1I8-1", "uniprot_id": [ { "id": "A0A0B4J1I8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1I8", "type": "external" } ], "mass": 12670.0, "length": 117, "protein_name": "Immunoglobulin kappa variable 4-59", "gene_name": "Igkv4-59", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv4-59", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa variable 4-59", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1I8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JGT0-1", "uniprot_id": [ { "id": "A0A0G2JGT0_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JGT0", "type": "external" } ], "mass": 12726.0, "length": 114, "protein_name": "Predicted gene 43218", "gene_name": "Gm43218", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm43218", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 43218", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JGT0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LI28-1", "uniprot_id": [ { "id": "A0A140LI28_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LI28", "type": "external" } ], "mass": 49639.0, "length": 432, "protein_name": "Family with sequence similarity 81, member B", "gene_name": "Fam81b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fam81b", "gene_names_refseq": "", "protein_names_uniprotkb": "Family with sequence similarity 81, member B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LI28-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GSX1-1", "uniprot_id": [ { "id": "A0A1B0GSX1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GSX1", "type": "external" } ], "mass": 19412.0, "length": 172, "protein_name": "Coiled coil domain containing 200", "gene_name": "Ccdc200", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 200 isoform 1", "refseq_ac": [ { "id": "NP_001359474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359474", "type": "external" } ], "gene_names_uniprotkb": "Ccdc200; Gm11634", "gene_names_refseq": "Ccdc200; Gm11634", "protein_names_uniprotkb": "Coiled coil domain containing 200", "protein_names_refseq": "coiled-coil domain-containing protein 200 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:667306)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GSX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Y7VJH8-1", "uniprot_id": [ { "id": "A0A1Y7VJH8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJH8", "type": "external" } ], "mass": 10110.0, "length": 109, "protein_name": "Predicted gene, 47969", "gene_name": "Gm47969", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm47969", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 47969", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VJH8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YUK6-1", "uniprot_id": [ { "id": "D3YUK6_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YUK6", "type": "external" } ], "mass": 97326.0, "length": 857, "protein_name": "Vomeronasal 2, receptor27", "gene_name": "Vmn2r27", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor27 precursor", "refseq_ac": [ { "id": "NP_001098112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098112", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r27", "gene_names_refseq": "EG232367; Vmn2r27", "protein_names_uniprotkb": "Vomeronasal 2, receptor27", "protein_names_refseq": "vomeronasal 2, receptor27 precursor; vomeronasal receptor Vmn2r27", "tax_id": 10090, "disease": "", "pathway": " (mmu:232367)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YUK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6YNI8-1", "uniprot_id": [ { "id": "F6YNI8_MOUSE", "url": "https://www.uniprot.org/uniprot/F6YNI8", "type": "external" } ], "mass": 16464.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad19", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 1A-like", "refseq_ac": [ { "id": "NP_001257651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257651", "type": "external" } ], "gene_names_uniprotkb": "Eif1ad19", "gene_names_refseq": "Eif1ad19; Gm21319", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4C", "protein_names_refseq": "eukaryotic translation initiation factor 1A-like", "tax_id": 10090, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:100861908)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6YNI8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UZV2-1", "uniprot_id": [ { "id": "G3UZV2_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UZV2", "type": "external" } ], "mass": 100229.0, "length": 921, "protein_name": "Interferon activated gene 206", "gene_name": "Ifi206", "organism": "Mouse", "refseq_name": "interferon activated gene 206", "refseq_ac": [ { "id": "NP_001359365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359365", "type": "external" } ], "gene_names_uniprotkb": "Ifi206; Gm4955", "gene_names_refseq": "EG240921; Gm4955; Ifi206; Pyblhin-C", "protein_names_uniprotkb": "Interferon activated gene 206", "protein_names_refseq": "interferon activated gene 206; signaling mucin HKR1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:102639543)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15557274;17786933;21750661;30779550;34428180", "class_list": "", "function": "Interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation, [RefSeq, PubMed]; P206 represents the newest HIN-200 family member discovered. It has distinct pattern of expression however maintains many of the hallmarks of HIN-200 proteins. [Ifi206], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3UZV2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UYU0-1", "uniprot_id": [ { "id": "G3UYU0_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UYU0", "type": "external" } ], "mass": 54224.0, "length": 520, "protein_name": "Mex3 RNA binding family member A", "gene_name": "Mex3a", "organism": "Mouse", "refseq_name": "RNA-binding protein MEX3A", "refseq_ac": [ { "id": "NP_001025061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025061", "type": "external" } ], "gene_names_uniprotkb": "Mex3a", "gene_names_refseq": "2700083E18Rik; Gm411; Mex3a; Rkhd4", "protein_names_uniprotkb": "Mex3 RNA binding family member A", "protein_names_refseq": "RNA-binding protein MEX3A; mex3 homolog A; ring finger and KH domain containing 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72640)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;28285904;32052574;36276637;36690670;37433992", "class_list": "", "function": "Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state. Publication Status: Online-Only, [RefSeq, PubMed]; MEX3A regulates Lgr5(+) stem cell maintenance in the developing intestinal epithelium., [RefSeq, PubMed]; Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment., [RefSeq, PubMed]; Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "G3UYU0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3KMI0-1", "uniprot_id": [ { "id": "J3KMI0_MOUSE", "url": "https://www.uniprot.org/uniprot/J3KMI0", "type": "external" } ], "mass": 25834.0, "length": 227, "protein_name": "Predicted gene, 20815", "gene_name": "Gm20815", "organism": "Mouse", "refseq_name": "spermiogenesis specific transcript on the Y family member", "refseq_ac": [ { "id": "NP_001017394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017394", "type": "external" } ], "gene_names_uniprotkb": "Gm20815", "gene_names_refseq": "Gm20815", "protein_names_uniprotkb": "Predicted gene, 20815", "protein_names_refseq": "spermiogenesis specific transcript on the Y family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039753)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3KMI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QPI8-1", "uniprot_id": [ { "id": "J3QPI8_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QPI8", "type": "external" } ], "mass": 16517.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad16", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC627873", "refseq_ac": [ { "id": "NP_001341505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341505", "type": "external" } ], "gene_names_uniprotkb": "Eif1ad16", "gene_names_refseq": "627873; Eif1ad16; Gm6803", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4C", "protein_names_refseq": "uncharacterized protein LOC627873", "tax_id": 10090, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:627873)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QPI8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6Y5-1", "uniprot_id": [ { "id": "K7N6Y5_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6Y5", "type": "external" } ], "mass": 24790.0, "length": 207, "protein_name": "Predicted gene 8011", "gene_name": "Gm8011", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm8011", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 8011", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6Y5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7MTV4-1", "uniprot_id": [ { "id": "L7MTV4_MOUSE", "url": "https://www.uniprot.org/uniprot/L7MTV4", "type": "external" } ], "mass": 35224.0, "length": 313, "protein_name": "Olfactory receptor family 10 subfamily AK member 8", "gene_name": "Or10ak8", "organism": "Mouse", "refseq_name": "olfactory receptor 1329", "refseq_ac": [ { "id": "NP_001011870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011870", "type": "external" } ], "gene_names_uniprotkb": "Or10ak8; Olfr1329", "gene_names_refseq": "MOR259-2; Olfr1329; Or10ak8", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily AK member 8", "protein_names_refseq": "GA_x6K02T2QD9B-18619941-18620882; olfactory receptor 1329; olfactory receptor MOR259-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258214)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7MTV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N2B8-1", "uniprot_id": [ { "id": "L7N2B8_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N2B8", "type": "external" } ], "mass": 98977.0, "length": 865, "protein_name": "Vomeronasal 2, receptor 61", "gene_name": "Vmn2r61", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r61 precursor", "refseq_ac": [ { "id": "NP_001098528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098528", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r61", "gene_names_refseq": "Casr-rs2; EG637873; Gprc2a-rs2; Vmn2r61", "protein_names_uniprotkb": "Vomeronasal 2, receptor 61", "protein_names_refseq": "G protein-coupled receptor, family C, group 2, member A, related sequence 2; calcium sensing receptor, related sequence 2; vomeronasal receptor Vmn2r61 precursor; vomeronasal receptor Vmn2r61", "tax_id": 10090, "disease": "", "pathway": " (mmu:637873)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N2B8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N2C7-1", "uniprot_id": [ { "id": "L7N2C7_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N2C7", "type": "external" } ], "mass": 24626.0, "length": 213, "protein_name": "Predicted gene 8122", "gene_name": "Gm8122", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm8122", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 8122", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N2C7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B6C4-1", "uniprot_id": [ { "id": "A0A075B6C4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B6C4", "type": "external" } ], "mass": 11803.0, "length": 109, "protein_name": "T cell receptor alpha variable 21-DV12", "gene_name": "Trav21-dv12", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav21-dv12", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 21-DV12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21606376;21750661;35999236", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009617 response to bacterium;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A075B6C4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YWG4-1", "uniprot_id": [ { "id": "A0A0A6YWG4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YWG4", "type": "external" } ], "mass": 13049.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 5-12-4", "gene_name": "Ighv5-12-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv5-12-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 5-12-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A6YWG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1J5-1", "uniprot_id": [ { "id": "A0A0B4J1J5_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1J5", "type": "external" } ], "mass": 12996.0, "length": 117, "protein_name": "Immunoglobulin heavy variable V9-3", "gene_name": "Ighv9-3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv9-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable V9-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1J5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1J6-1", "uniprot_id": [ { "id": "A0A0B4J1J6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1J6", "type": "external" } ], "mass": 13550.0, "length": 119, "protein_name": "Immunoglobulin heavy variable 10-1", "gene_name": "Ighv10-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv10-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 10-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1J6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JDE9-1", "uniprot_id": [ { "id": "A0A0G2JDE9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JDE9", "type": "external" } ], "mass": 2108.0, "length": 20, "protein_name": "T cell receptor alpha joining 22", "gene_name": "Traj22", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traj22", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 22", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JDE9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JDZ0-1", "uniprot_id": [ { "id": "A0A0G2JDZ0_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JDZ0", "type": "external" } ], "mass": 2086.0, "length": 21, "protein_name": "T cell receptor alpha joining 56", "gene_name": "Traj56", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traj56", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 56", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JDZ0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JE22-1", "uniprot_id": [ { "id": "A0A0G2JE22_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JE22", "type": "external" } ], "mass": 1942.0, "length": 20, "protein_name": "T cell receptor alpha joining 44", "gene_name": "Traj44", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traj44", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 44", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JE22-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JES9-1", "uniprot_id": [ { "id": "A0A0G2JES9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JES9", "type": "external" } ], "mass": 12607.0, "length": 117, "protein_name": "Immunoglobulin kappa chain variable 4-54", "gene_name": "Igkv4-54", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv4-54", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 4-54", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JES9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JEZ6-1", "uniprot_id": [ { "id": "A0A0G2JEZ6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JEZ6", "type": "external" } ], "mass": 1448.0, "length": 13, "protein_name": "Immunoglobulin kappa joining 1", "gene_name": "Igkj1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkj1", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa joining 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JEZ6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8M4-1", "uniprot_id": [ { "id": "A0A140T8M4_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140T8M4", "type": "external" } ], "mass": 11116.0, "length": 101, "protein_name": "Immunoglobulin kappa variable 8-19", "gene_name": "Igkv8-19", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv8-19", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa variable 8-19", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;34887587", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A140T8M4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GS61-1", "uniprot_id": [ { "id": "A0A1B0GS61_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GS61", "type": "external" } ], "mass": 22749.0, "length": 206, "protein_name": "Coiled coil domain 201", "gene_name": "Ccdc201", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccdc201; Gm11985", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled coil domain 201", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GS61-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YX25-1", "uniprot_id": [ { "id": "D3YX25_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YX25", "type": "external" } ], "mass": 10736.0, "length": 99, "protein_name": "Prostate and testis expressed 12", "gene_name": "Pate12", "organism": "Mouse", "refseq_name": "prostate and testis expressed Q precursor", "refseq_ac": [ { "id": "NP_001161058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161058", "type": "external" } ], "gene_names_uniprotkb": "Pate12; Gm7257", "gene_names_refseq": "EG639025; Gm7257; Pate-q; Pate12", "protein_names_uniprotkb": "Prostate and testis expressed 12", "protein_names_refseq": "prostate and testis expressed Q precursor; prostate and testis expressed Q", "tax_id": 10090, "disease": "", "pathway": " (mmu:639025)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YX25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5M2-1", "uniprot_id": [ { "id": "A0A075B5M2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5M2", "type": "external" } ], "mass": 10153.0, "length": 94, "protein_name": "Immunoglobulin kappa chain variable 4-61", "gene_name": "Igkv4-61", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv4-61", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 4-61", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5M2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SP45-1", "uniprot_id": [ { "id": "Q5SP45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SP45", "type": "external" } ], "mass": 17888.0, "length": 163, "protein_name": "RIKEN cDNA 5730522E02 gene", "gene_name": "5730522E02Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "5730522E02Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RIKEN cDNA 5730522E02 gene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SP45-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGI1-1", "uniprot_id": [ { "id": "F193A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGI1", "type": "external" } ], "mass": 166901.0, "length": 1517, "protein_name": "Protein FAM193A", "gene_name": "Fam193a", "organism": "Mouse", "refseq_name": "protein FAM193A", "refseq_ac": [ { "id": "NP_001230052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230052", "type": "external" } ], "gene_names_uniprotkb": "Fam193a", "gene_names_refseq": "Fam193a", "protein_names_uniprotkb": "Protein FAM193A", "protein_names_refseq": "family with sequence similarity 193, member A; protein FAM193A", "tax_id": 10090, "disease": "", "pathway": " (mmu:231128)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Acts as a positive regulator of p53/TP53 by interacting with p53 repressors MDM2 and MDM4 and destabilizing MDM4 which leads to enhanced p53 transcriptional activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0QWZ1;Q499G1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901798 positive regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGI1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51162-1", "uniprot_id": [ { "id": "FABP6_MOUSE", "url": "https://www.uniprot.org/uniprot/P51162", "type": "external" } ], "mass": 14486.0, "length": 128, "protein_name": "Gastrotropin", "gene_name": "Fabp6", "organism": "Mouse", "refseq_name": "gastrotropin", "refseq_ac": [ { "id": "NP_032401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032401", "type": "external" } ], "gene_names_uniprotkb": "Fabp6; Illbp", "gene_names_refseq": "Fabp6; GT; I-15P; I-BABP; ILBP3; ILBP; Illbp", "protein_names_uniprotkb": "Gastrotropin; Fatty acid-binding protein 6; GT; ILBP; Ileal lipid-binding protein", "protein_names_refseq": "gastrotropin; ileal bile acid-binding protein; ileal lipid-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16204); (R-MMU-159418); (R-MMU-163560)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12651103;23251388;25754072;33527741;8089185", "class_list": "", "function": "Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (PubMed:23251388). Stimulates gastric acid and pepsinogen secretion (By similarity)., [UniProtKB, UniProtKB, PubMed]; Sexually dimorphic response of mice to the Western-style diet caused by deficiency of fatty acid binding protein 6 (Fabp6)., [RefSeq, PubMed]; The ligand binding activity of purified recombinant murine ILBP (mILBP) in vitro; mILBP exhibits a preference for certain species of bile and fatty acids., [RefSeq, PubMed]; The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]., [RefSeq]; The results demonstrate that ilbp is involved in the apical to basolateral transport of bile acids in ileal enterocytes, and is vital for the maintenance of bile acid homeostasis in the enterohepatic circulation (EHC) in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRT9", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015908 fatty acid transport;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51162-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2K0-1", "uniprot_id": [ { "id": "F193B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2K0", "type": "external" } ], "mass": 95084.0, "length": 892, "protein_name": "Protein FAM193B", "gene_name": "Fam193b", "organism": "Mouse", "refseq_name": "protein FAM193B isoform 1", "refseq_ac": [ { "id": "NP_663357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663357", "type": "external" } ], "gene_names_uniprotkb": "Fam193b; Kiaa1931", "gene_names_refseq": "Fam193b; IRIZIO; Kiaa1931", "protein_names_uniprotkb": "Protein FAM193B", "protein_names_refseq": "protein FAM193B isoform 1; protein FAM193B", "tax_id": 10090, "disease": "", "pathway": " (mmu:212483)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21177767;21183079;21750661", "class_list": "", "function": "Expression of full length IRIZIO cDNA also cooperated with PAX3-FOXO1 in the transformation of Arf-/- myoblasts. Given that IRIZIO is expressed at increased levels in rhabdomyosarcoma, it might contribute to rhabdomyosarcomagenesis in humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z63;Q8K1B4;Q8VCA1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U2K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CID3-1", "uniprot_id": [ { "id": "FA20A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CID3", "type": "external" } ], "mass": 61526.0, "length": 541, "protein_name": "Pseudokinase FAM20A", "gene_name": "Fam20a", "organism": "Mouse", "refseq_name": "pseudokinase FAM20A precursor", "refseq_ac": [ { "id": "NP_722477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722477", "type": "external" } ], "gene_names_uniprotkb": "Fam20a", "gene_names_refseq": "Fam20a", "protein_names_uniprotkb": "Pseudokinase FAM20A", "protein_names_refseq": "ortholog of human family with sequence similarity 20, member A FAM20A; protein FAM20A; pseudokinase FAM20A precursor; pseudokinase FAM20A", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1G (Disease Ontology:DOID:0110066)", "pathway": " (mmu:208659); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15676076;20847595;21549343;22732358;22900076;25789606;31667691;34428180;35278791;37625561", "class_list": "", "function": "Epithelial-specific deletion of FAM20A leads to short root defects., [RefSeq, PubMed]; Fam20a null mice develop amelogenesis imperfecta and ectopic mineralization of muscular arteries and the gene is highly expressed in ameloblasts and the parathyroid gland, [RefSeq, PubMed]; Possible link between Fam20a mutation and growth disorder Publication Status: Online-Only, [RefSeq, PubMed]; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals., [UniProtKB, PubMed]; Resulta indicate that family with sequence similarity 20 member A (FAM20A) is essential for amelogenesis, but is dispensable for dentinogenesis., [RefSeq, PubMed]; The effect and mechanism of gene Fam20a on the development and function of salivary glands in mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0009617 response to bacterium;GO:0031214 biomineral tissue development;GO:0070166 enamel mineralization;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CID3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES89-1", "uniprot_id": [ { "id": "EXTL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES89", "type": "external" } ], "mass": 37391.0, "length": 330, "protein_name": "Exostosin-like 2", "gene_name": "Extl2", "organism": "Mouse", "refseq_name": "exostosin-like 2 isoform a", "refseq_ac": [ { "id": "NP_001156986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156986", "type": "external" } ], "gene_names_uniprotkb": "Extl2; Extr2", "gene_names_refseq": "3000001D04Rik; Extl2", "protein_names_uniprotkb": "Exostosin-like 2; 2.4.1.223; Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; Alpha-GalNAcT EXTL2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase", "protein_names_refseq": "EXT-related protein 2; alpha-1,4-N-acetylhexosaminyltransferase EXTL2; alpha-GalNAcT EXTL2; exostoses (multiple)-like 2; exostoses-like 2; exostosin-like 2 isoform a; exostosin-like 2; exotoses (multiple)-like 2; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:58193); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10965119;12562774;23395820;23734945;24176719;29305908;32347583;32703234;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling., [RefSeq, PubMed]; Crystal structure of EXTL2, [RefSeq, PubMed]; Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis., [RefSeq, PubMed]; EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.[review] Review article, [RefSeq, PubMed]; EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a 'quality control system' for proteoglycans, [RefSeq, PubMed]; EXTL2-mediated regulation of glycosaminoglycans synthesis is important for tissue regeneration processes following liver injury., [RefSeq, PubMed]; Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains., [UniProtKB, UniProtKB]; The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505Q8;Q9CX90", "ec_number_list": [ { "id": "2.4.1.223", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.223", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0005539 glycosaminoglycan binding;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0019276 UDP-N-acetylgalactosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ES89-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14CH0-1", "uniprot_id": [ { "id": "F171B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14CH0", "type": "external" } ], "mass": 92045.0, "length": 825, "protein_name": "Protein FAM171B", "gene_name": "Fam171b", "organism": "Mouse", "refseq_name": "protein FAM171B precursor", "refseq_ac": [ { "id": "NP_780723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780723", "type": "external" } ], "gene_names_uniprotkb": "Fam171b", "gene_names_refseq": "D430039N05Rik; Fam171b", "protein_names_uniprotkb": "Protein FAM171B", "protein_names_refseq": "protein FAM171B precursor; protein FAM171B", "tax_id": 10090, "disease": "", "pathway": " (mmu:241520)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;30899004;32848054;34052262;34678516;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C756;Q8CAF3;Q8CBZ4;Q8CFT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q14CH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGZ2-1", "uniprot_id": [ { "id": "F168A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGZ2", "type": "external" } ], "mass": 26184.0, "length": 244, "protein_name": "Protein FAM168A", "gene_name": "Fam168a", "organism": "Mouse", "refseq_name": "protein FAM168A isoform 2", "refseq_ac": [ { "id": "NP_848879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848879", "type": "external" } ], "gene_names_uniprotkb": "Fam168a; Kiaa0280", "gene_names_refseq": "2610030B18Rik; B930006L02Rik; Fam168a; mKIAA0280", "protein_names_uniprotkb": "Protein FAM168A", "protein_names_refseq": "protein FAM168A isoform 2; protein FAM168A", "tax_id": 10090, "disease": "", "pathway": " (mmu:319604)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22645316;24129315;32782141", "class_list": "", "function": "In cancer context, decreases POLB ubiquitination and stabilizes its protein levels. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Results in protection of cells from induced-DNA damage and apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVC2;Q80U50;Q8BGN7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:1905053 positive regulation of base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N13-1", "uniprot_id": [ { "id": "HDAC9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N13", "type": "external" } ], "mass": 65687.0, "length": 588, "protein_name": "Histone deacetylase 9", "gene_name": "Hdac9", "organism": "Mouse", "refseq_name": "histone deacetylase 9 isoform 2", "refseq_ac": [ { "id": "NP_077038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077038", "type": "external" } ], "gene_names_uniprotkb": "Hdac9; Hdac7b; Hdrp; Mitr", "gene_names_refseq": "D030072B18Rik; HD7B; HD9; HDRP; Hdac7b; Hdac9; Mitr; mKIAA0744", "protein_names_uniprotkb": "Histone deacetylase 9; 3.5.1.98; HD7b; HD9; Histone deacetylase 7B; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR", "protein_names_refseq": "MEF2-interacting transcription repressor MITR; histone deacetylase 7B; histone deacetylase 9 isoform 2; histone deacetylase-related protein", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:79221)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11022042;11390982;12202037;12242305;15546868;15567413;15711539;16611996;17101791;21183079;21750661;34428180;38528189;38672510;38967258", "class_list": "", "function": "Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA SNHG12 suppresses adipocyte inflammation and insulin resistance by regulating the HDAC9/Nrf2 axis., [RefSeq, PubMed]; MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase, [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQN7;Q8R4Y6;Q9EPT2", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0005080 protein kinase C binding;GO:0004407 histone deacetylase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99N13-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70175-1", "uniprot_id": [ { "id": "DLG3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70175", "type": "external" } ], "mass": 93482.0, "length": 849, "protein_name": "Disks large homolog 3", "gene_name": "Dlg3", "organism": "Mouse", "refseq_name": "disks large homolog 3 isoform 2", "refseq_ac": [ { "id": "NP_001171249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171249", "type": "external" } ], "gene_names_uniprotkb": "Dlg3; Dlgh3", "gene_names_refseq": "Dlg3; Dlgh3; SAP102; mKIAA1232", "protein_names_uniprotkb": "Disks large homolog 3; SAP-102; SAP102; Synapse-associated protein 102", "protein_names_refseq": "discs, large homolog 3; disks large homolog 3 isoform 2; disks large homolog 3; synapse-associated protein 102", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); non-syndromic X-linked intellectual disability 90 (Disease Ontology:DOID:0112041); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:53310); (R-MMU-438066); (R-MMU-451308); (R-MMU-5673001); (R-MMU-6794361); (R-MMU-8849932)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12738960;18034455;19243221;21119615;21183079;21750661;25780553;34203471;34244435;34428180;40684658", "class_list": "", "function": "MAGUKs are essential, but redundant, in long-term potentiation., [RefSeq, PubMed]; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling., [UniProtKB]; SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0035418 protein localization to synapse", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P70175-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QVP9-1", "uniprot_id": [ { "id": "FAK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QVP9", "type": "external" } ], "mass": 115794.0, "length": 1009, "protein_name": "Protein-tyrosine kinase 2-beta", "gene_name": "Ptk2b", "organism": "Mouse", "refseq_name": "protein-tyrosine kinase 2-beta isoform 1", "refseq_ac": [ { "id": "NP_001155838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155838", "type": "external" } ], "gene_names_uniprotkb": "Ptk2b; Fak2; Pyk2; Raftk", "gene_names_refseq": "CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PYK2; Ptk2b; Raftk", "protein_names_uniprotkb": "Protein-tyrosine kinase 2-beta; 2.7.10.2; CADTK; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK 2; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2; RAFTK; Related adhesion focal tyrosine kinase", "protein_names_refseq": "CAK-beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein-tyrosine kinase 2-beta isoform 1; protein-tyrosine kinase 2-beta; related adhesion focal tyrosine kinase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (mmu:19229); (R-MMU-391160); (R-MMU-4420097); (R-MMU-9013420); (R-MMU-9020558)", "pathway_count": 5, "publication_count": 63, "publication_id_list": "10469599;10881171;11238453;11420674;11493697;12486027;12674328;12960403;14739300;15561106;17537919;17698736;17846174;17947660;17963734;18195107;18391070;18587400;19144319;19561089;19880522;19884968;20529287;20688918;21183079;21195757;21640103;21750661;22257498;22342188;22544749;22811489;22984613;24340001;24841674;26098895;26458186;26495903;26552846;26663135;27086609;28555636;28643946;29782321;29803828;30576317;30644388;30664624;31219806;31330317;31574128;31604999;32693110;32911704;33300544;34428180;36210013;38552722;38719751;39627609;7499242;8940124;9422762", "class_list": "", "function": "Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia., [RefSeq, PubMed]; Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3beta-Srebp2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G protein-coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ16;G3X8V1", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0030546 signaling receptor activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 6.6, "record_id": "Q9QVP9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XI1-1", "uniprot_id": [ { "id": "DUS3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XI1", "type": "external" } ], "mass": 71078.0, "length": 637, "protein_name": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like", "gene_name": "Dus3l", "organism": "Mouse", "refseq_name": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1", "refseq_ac": [ { "id": "NP_659107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659107", "type": "external" } ], "gene_names_uniprotkb": "Dus3l", "gene_names_refseq": "Dus3l", "protein_names_uniprotkb": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; 1.3.1.-; 1.3.1.89; mRNA-dihydrouridine synthase DUS3L; tRNA-dihydrouridine synthase 3-like", "protein_names_refseq": "mRNA-dihydrouridine synthase DUS3L; putative zinc finger protein MA23; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224907)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;25153642;28135057;28528544;31219806;34428180", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZQ1;Q7TT12", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "1.3.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.89", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity;GO:0102265 tRNA-dihydrouridine47 synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91XI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88662-1", "uniprot_id": [ { "id": "EMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88662", "type": "external" } ], "mass": 19747.0, "length": 172, "protein_name": "Epithelial membrane protein 2", "gene_name": "Emp2", "organism": "Mouse", "refseq_name": "epithelial membrane protein 2", "refseq_ac": [ { "id": "NP_031955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031955", "type": "external" } ], "gene_names_uniprotkb": "Emp2; Xmp", "gene_names_refseq": "Emp2; XMP", "protein_names_uniprotkb": "Epithelial membrane protein 2; EMP-2; Protein XMP", "protein_names_refseq": "EMP-2; epithelial membrane protein 2", "tax_id": 10090, "disease": "nephrotic syndrome type 10 (Disease Ontology:DOID:0080386); placental insufficiency (Disease Ontology:DOID:3891)", "pathway": " (mmu:13731)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12189152;12710941;12763482;14978215;16216233;16487956;17609206;18400107;25428506;28295343;30773261;31550239;33774530;9615230", "class_list": "", "function": "Addressed the normal function of EMP2 by testing the prediction that it influences integrin-related cell functions, [RefSeq, PubMed]; Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface., [RefSeq, PubMed]; Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (PubMed:31550239). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:14978215, PubMed:17609206). Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (PubMed:14978215). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (PubMed:12763482). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:12189152). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity). Regulates cell contraction through PTK2 activation (By similarity). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (By similarity). Positively regulates cell proliferation (By similarity). Plays a role during cell death and cell blebbing (By similarity). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16216233, PubMed:16487956). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (PubMed:28295343). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (PubMed:30773261). May play a role in glomerular filtration (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death., [RefSeq, PubMed]; This protein is expressed in discrete anatomical regions of the eye., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0072659 protein localization to plasma membrane;GO:0003093 regulation of glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88662-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51906-1", "uniprot_id": [ { "id": "EAA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P51906", "type": "external" } ], "mass": 56694.0, "length": 523, "protein_name": "Excitatory amino acid transporter 3", "gene_name": "Slc1a1", "organism": "Mouse", "refseq_name": "excitatory amino acid transporter 3", "refseq_ac": [ { "id": "NP_033225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033225", "type": "external" } ], "gene_names_uniprotkb": "Slc1a1; Eaac1; Eaat3", "gene_names_refseq": "D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1; Slc1a1", "protein_names_uniprotkb": "Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1", "protein_names_refseq": "excitatory amino acid carrier 2; excitatory amino acid transporter 3; excitatory amino-acid carrier 1; glutamate transporter mEAAC2; sodium-dependent glutamate/aspartate transporter 3", "tax_id": 10090, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); dicarboxylic aminoaciduria (Disease Ontology:DOID:0060650); schizophrenia 18 (Disease Ontology:DOID:0070093); neurodegenerative disease (Disease Ontology:DOID:1289); low tension glaucoma (Disease Ontology:DOID:13544); epilepsy (Disease Ontology:DOID:1826); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (mmu:20510); (R-MMU-210500); (R-MMU-9958863)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12119102;18684713;21183079;26739563;30840898;33300544;37542723;37803915;39927985;7766664;9233792", "class_list": "", "function": "EAAT3 impedes oligodendrocyte remyelination in chronic cerebral hypoperfusion-induced white matter injury., [RefSeq, PubMed]; HIF-1alpha drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1., [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:12119102, PubMed:18684713). Can also transport L-cysteine (PubMed:30840898). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:9233792). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:9233792). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (PubMed:30840898). Negatively regulated by ARL6IP5 (PubMed:12119102)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35869;O35875;Q6P1F7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005253 monoatomic anion channel activity;GO:0015108 chloride transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0071577 zinc ion transmembrane transport;GO:0071242 cellular response to ammonium ion;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P51906-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60229-1", "uniprot_id": [ { "id": "EIF3E_MOUSE", "url": "https://www.uniprot.org/uniprot/P60229", "type": "external" } ], "mass": 52221.0, "length": 445, "protein_name": "Eukaryotic translation initiation factor 3 subunit E", "gene_name": "Eif3e", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit E", "refseq_ac": [ { "id": "NP_032414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032414", "type": "external" } ], "gene_names_uniprotkb": "Eif3e; Eif3s6; Int6", "gene_names_refseq": "48kDa; Eif3e; Eif3s6; Int6; eIF3-p46; eIF3-p48", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit E; Eukaryotic translation initiation factor 3 subunit 6; MMTV integration site 6; Mammary tumor-associated protein INT-6; Viral integration site protein INT-6; eIF-3 p48; eIF3e", "protein_names_refseq": "MMTV integration site 6; eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3, subunit 6 48kDa; mammary tumor integration site 6; mammary tumor-associated protein INT-6; viral integration site protein INT-6", "tax_id": 10090, "disease": "intermittent claudication (Disease Ontology:DOID:3669)", "pathway": " (mmu:16341); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "15592455;17525332;17581632;22645316;25605945;25758454;28528544;34428180;37453647;37507081;7853537;9260927", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins., [UniProtKB, PubMed, HAMAP]; EIF3e is an angiogenesis suppressor. Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O43902;Q64058;Q64059;Q64252", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016605 PML body", "go_biological_process": "GO:0006413 translational initiation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P60229-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VPQ9-1", "uniprot_id": [ { "id": "EAF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2VPQ9", "type": "external" } ], "mass": 21649.0, "length": 191, "protein_name": "Chromatin modification-related protein MEAF6", "gene_name": "Meaf6", "organism": "Mouse", "refseq_name": "chromatin modification-related protein MEAF6 isoform 2", "refseq_ac": [ { "id": "NP_001277630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277630", "type": "external" } ], "gene_names_uniprotkb": "Meaf6", "gene_names_refseq": "2310005N01Rik; 2810036M01Rik; Meaf6", "protein_names_uniprotkb": "Chromatin modification-related protein MEAF6; Esa1-associated factor 6 homolog; MYST/Esa1-associated factor 6; Protein EAF6 homolog", "protein_names_refseq": "chromatin modification-related protein MEAF6 isoform 2; chromatin modification-related protein MEAF6; esa1-associated factor 6 homolog; protein EAF6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70088); (R-MMU-3214847); (R-MMU-6804758)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;21750661;23806337;32918898;34428180", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASC6;Q9D7J5", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0036408 histone H3K14 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000776 kinetochore", "go_biological_process": "GO:0050793 regulation of developmental process;GO:2000278 regulation of DNA biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2VPQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XUX1-1", "uniprot_id": [ { "id": "DUSTY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6XUX1", "type": "external" } ], "mass": 104901.0, "length": 927, "protein_name": "Dual serine/threonine and tyrosine protein kinase", "gene_name": "Dstyk", "organism": "Mouse", "refseq_name": "dual serine/threonine and tyrosine protein kinase", "refseq_ac": [ { "id": "NP_766104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766104", "type": "external" } ], "gene_names_uniprotkb": "Dstyk; Ripk5", "gene_names_refseq": "A930019K20Rik; C430014H23Rik; C820013G01; Dstyk; Ripk5", "protein_names_uniprotkb": "Dual serine/threonine and tyrosine protein kinase; 2.7.12.1; Dusty PK; Dusty protein kinase; Receptor-interacting serine/threonine-protein kinase 5", "protein_names_refseq": "dual serine/threonine and tyrosine protein kinase; dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5", "tax_id": 10090, "disease": "congenital anomalies of the kidney and urinary tract 1 (Disease Ontology:DOID:0080206); hereditary spastic paraplegia 23 (Disease Ontology:DOID:0110774)", "pathway": " (mmu:213452)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17123648;21750661;23862974;25400726;34428180;37746849", "class_list": "", "function": "Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; DSTYK homozygous knockout mice show impaired capabilities of learning and memory. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULK4;Q5EBN5;Q8C7D4;Q8C923;Q9CTP7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0033674 positive regulation of kinase activity;GO:0044344 cellular response to fibroblast growth factor stimulus;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6XUX1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA79-1", "uniprot_id": [ { "id": "DPEP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA79", "type": "external" } ], "mass": 54247.0, "length": 493, "protein_name": "Dipeptidase 3", "gene_name": "Dpep3", "organism": "Mouse", "refseq_name": "dipeptidase 3 precursor", "refseq_ac": [ { "id": "NP_082236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082236", "type": "external" } ], "gene_names_uniprotkb": "Dpep3; Mbd3", "gene_names_refseq": "1700018F16Rik; Dpep3; MBD-3; MLZ-136", "protein_names_uniprotkb": "Dipeptidase 3; MBD-3; MLZ-136; Membrane-bound dipeptidase 3; Protein expressed in male leptotene and zygotene spermatocytes 136", "protein_names_refseq": "dipeptidase 3 precursor; protein expressed in male leptotene and zygotene spermatocytes 136; putative membrane-bound dipeptidase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71854)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12738806;20173027;20339383;21724266;30084848;31212048;32325220;34428180", "class_list": "", "function": "Cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3, [RefSeq, PubMed]; DPEP3 forms complexes with Ts4-immunoreactive molecules, such as TEX101, on the surfaces of spermatocytes, spermatids, and testicular spermatozoa., [RefSeq, PubMed]; Data showed that Dpep3 mRNA was specifically detected in testis and DPEP3 is evolutionarily conserved among eutherians. Dpep3 knockout mice displayed normal fertility even a significant reduction in sperm count. These findings inferred that despite of the testis-specific expression pattern, Dpep3 is dispensable for mouse fertility., [RefSeq, PubMed]; Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine (PubMed:32325220). The absence of activity may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). Does not hydrolyze leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Does not hydrolyze the beta-lactam antibiotic imipenem (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DA79-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C739-1", "uniprot_id": [ { "id": "F110B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C739", "type": "external" } ], "mass": 40360.0, "length": 366, "protein_name": "Protein FAM110B", "gene_name": "Fam110b", "organism": "Mouse", "refseq_name": "protein FAM110B", "refseq_ac": [ { "id": "NP_775602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775602", "type": "external" } ], "gene_names_uniprotkb": "Fam110b", "gene_names_refseq": "1700012H17Rik; 5031405P22; Fam110b", "protein_names_uniprotkb": "Protein FAM110B", "protein_names_refseq": "protein FAM110B", "tax_id": 10090, "disease": "", "pathway": " (mmu:242297)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKH0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C739-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGI4-1", "uniprot_id": [ { "id": "FA13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGI4", "type": "external" } ], "mass": 79424.0, "length": 693, "protein_name": "Protein FAM13A", "gene_name": "Fam13a", "organism": "Mouse", "refseq_name": "protein FAM13A", "refseq_ac": [ { "id": "NP_705802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705802", "type": "external" } ], "gene_names_uniprotkb": "Fam13a; Fam13a1; Precm1", "gene_names_refseq": "D430015B01Rik; FAM13A1; Fam13a; Precm1", "protein_names_uniprotkb": "Protein FAM13A; Precm1 protein", "protein_names_refseq": "protein FAM13A", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:58909); (R-MMU-8980692); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15234000;21183079;21750661;26371245;26862784;30084848;32053709;32193374;34224973;35820727", "class_list": "", "function": "(Microbial infection) Plays a role in the clearance of Pseudomonas aeruginosa by macrophages (PubMed:26371245). In complex with ANXA2, promotes activation of Rho GTPases following P.aeruginosa infection (PubMed:26371245)., [UniProtKB, PubMed]; A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. Erratum:[Am J Respir Crit Care Med. 2020 Dec 15;202(12):1746. doi: 10.1164/rccm.v202erratum8. PMID: 33320073], [RefSeq, PubMed]; Fam13a expression was reduced in the lungs of mice with hypoxia-induced pulmonary hypertension. Genetic loss of Fam13a exacerbated pulmonary hypertension in mice exposed to chronic hypoxia in association with deteriorated pulmonary artery remodeling. Study data revealed a protective role of Fam13a in the development of pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution. Publication Status: Online-Only, [RefSeq, PubMed]; Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ91", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08579-1", "uniprot_id": [ { "id": "EMD_MOUSE", "url": "https://www.uniprot.org/uniprot/O08579", "type": "external" } ], "mass": 29436.0, "length": 259, "protein_name": "Emerin", "gene_name": "Emd", "organism": "Mouse", "refseq_name": "emerin isoform 1", "refseq_ac": [ { "id": "NP_031953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031953", "type": "external" } ], "gene_names_uniprotkb": "Emd; Sta", "gene_names_refseq": "Emd; Sta", "protein_names_uniprotkb": "Emerin", "protein_names_refseq": "emerin isoform 1", "tax_id": 10090, "disease": "X-linked Emery-Dreifuss muscular dystrophy 1 (Disease Ontology:DOID:0070246); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:13726); (R-MMU-2980766); (R-MMU-2995383); (R-MMU-4419969); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9609523)", "pathway_count": 9, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10579712;12670476;18230648;19131326;19933576;21183079;21750661;25428506;31219806;32848054;32923640;34203471;34428180;36852467;37940872;40021952;40885482;9107678", "class_list": "", "function": "Emerin and lamin A/C are bound to actin at the late stages of myotube differentiation, [RefSeq, PubMed]; Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation. Publication Status: Online-Only, [RefSeq, PubMed]; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells., [UniProtKB, UniProtKB]; This gene is the founding member of the LEM (Lap2beta, Emerin, and Man1) domain gene family. It encodes an integral membrane protein of the inner nuclear membrane. This gene may be involved in transcriptional regulation and genomic organization. In humans, mutations in this gene cause a class of diseases called laminopathies, which includes Emery-Dreifuss muscular dystrophy (EDMD). [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIH6;Q3UJP3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1990000 amyloid fibril formation;GO:0046827 positive regulation of protein export from nucleus;GO:0071363 cellular response to growth factor stimulus;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O08579-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNF9-1", "uniprot_id": [ { "id": "F117A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNF9", "type": "external" } ], "mass": 48054.0, "length": 451, "protein_name": "Protein FAM117A", "gene_name": "Fam117a", "organism": "Mouse", "refseq_name": "protein FAM117A", "refseq_ac": [ { "id": "NP_766131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766131", "type": "external" } ], "gene_names_uniprotkb": "Fam117a", "gene_names_refseq": "5730593F17Rik; Fam117a", "protein_names_uniprotkb": "Protein FAM117A", "protein_names_refseq": "protein FAM117A", "tax_id": 10090, "disease": "", "pathway": " (mmu:215512)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJJ0;Q3TND5;Q8BJY9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUM6-1", "uniprot_id": [ { "id": "F163B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUM6", "type": "external" } ], "mass": 18306.0, "length": 167, "protein_name": "Protein FAM163B", "gene_name": "Fam163b", "organism": "Mouse", "refseq_name": "protein FAM163B", "refseq_ac": [ { "id": "NP_780636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780636", "type": "external" } ], "gene_names_uniprotkb": "Fam163b", "gene_names_refseq": "C630035N08Rik; Fam163b", "protein_names_uniprotkb": "Protein FAM163B", "protein_names_refseq": "protein FAM163B", "tax_id": 10090, "disease": "", "pathway": " (mmu:109349)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;22645316;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BUM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD58-1", "uniprot_id": [ { "id": "EVI2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD58", "type": "external" } ], "mass": 47993.0, "length": 444, "protein_name": "Protein EVI2B", "gene_name": "Evi2b", "organism": "Mouse", "refseq_name": "protein EVI2B precursor", "refseq_ac": [ { "id": "NP_001070964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070964", "type": "external" } ], "gene_names_uniprotkb": "Evi2b", "gene_names_refseq": "Evi-2; Evi2b; Evi2", "protein_names_uniprotkb": "Protein EVI2B; EVI-2B; Ecotropic viral integration site 2B protein", "protein_names_refseq": "EVI-2B; ecotropic viral integration site 2B protein; protein EVI2B precursor; protein EVI2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:101488212); (mmu:216984)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17242355;18250455;19144319;20485683;21183079;21913724;25428506;26495903;27802388;28011936;28186500;29187734;35984892;39627609", "class_list": "", "function": "Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1A3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0043066 negative regulation of apoptotic process;GO:0061515 myeloid cell development;GO:2000035 regulation of stem cell division;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VD58-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4P8-1", "uniprot_id": [ { "id": "HECW1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4P8", "type": "external" } ], "mass": 179467.0, "length": 1604, "protein_name": "E3 ubiquitin-protein ligase HECW1", "gene_name": "Hecw1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HECW1", "refseq_ac": [ { "id": "NP_001074817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074817", "type": "external" } ], "gene_names_uniprotkb": "Hecw1; Kiaa0322; Nedl1", "gene_names_refseq": "9330116H24Rik; E130207I19Rik; Hecw1; Nedl1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECW1; 2.3.2.26; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1; mNEDL1", "protein_names_refseq": "E3 ubiquitin-protein ligase HECW1; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1; mNEDL1", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477)", "pathway": " (mmu:94253); (R-MMU-4641258)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;14684739;16452087;21183079;21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YZ67;Q6A086;Q8BIA6;Q8BKC2;Q8BKL3;Q8BKZ8", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4P8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2N4-1", "uniprot_id": [ { "id": "DTNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2N4", "type": "external" } ], "mass": 84067.0, "length": 746, "protein_name": "Dystrobrevin alpha", "gene_name": "Dtna", "organism": "Mouse", "refseq_name": "dystrobrevin alpha isoform a", "refseq_ac": [ { "id": "NP_001272736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272736", "type": "external" } ], "gene_names_uniprotkb": "Dtna; Dtn", "gene_names_refseq": "2210407P21Rik; DTN-A; Dtna; Dtn; Gm19389; a-DB-1; adbn", "protein_names_uniprotkb": "Dystrobrevin alpha; Alpha-dystrobrevin; DTN-A", "protein_names_refseq": "alpha-dystrobrevin; dystrobrevin alpha isoform a", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); left ventricular noncompaction (Disease Ontology:DOID:0060480); myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 (Disease Ontology:DOID:0061184); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:13527); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10570976;11316798;14623885;21183079;21750661;22577143;25428506;29118297;32587503;35820727;36045406;38507070;7547961;8631824;9119373;9214383;9701558", "class_list": "", "function": "Alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in synapse maturation and required for normal muscle function., [UniProtKB]; Plasticity and structural alterations of mitochondria and sarcoplasmic organelles in muscles of mice deficient in alpha-dystrobrevin, a component of the dystrophin-glycoprotein complex., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97319;Q61498;Q61499;Q9QZZ5;Q9WUL9;Q9WUM0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030424 axon", "go_biological_process": "GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D2N4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45VK7-1", "uniprot_id": [ { "id": "DYHC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q45VK7", "type": "external" } ], "mass": 492339.0, "length": 4306, "protein_name": "Cytoplasmic dynein 2 heavy chain 1", "gene_name": "Dync2h1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 2 heavy chain 1 isoform 1", "refseq_ac": [ { "id": "NP_084127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084127", "type": "external" } ], "gene_names_uniprotkb": "Dync2h1; Dhc1b; Dnchc2; Kiaa1997", "gene_names_refseq": "4432416O06Rik; D030010H02Rik; D330044F14Rik; DHC11; DHC1b; DHC2; Dnchc2; Dync2h1; b2b414Clo; m152Asp; m407Asp; mDHC11", "protein_names_uniprotkb": "Cytoplasmic dynein 2 heavy chain 1; Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11; Dynein heavy chain isotype 1B; mDHC11", "protein_names_refseq": "cytoplasmic dynein 2 heavy chain 1 isoform 1; cytoplasmic dynein 2 heavy chain 1; cytoplasmic dynein heavy chain 2; dynein heavy chain 11; dynein heavy chain isotype 1B", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); asphyxiating thoracic dystrophy 3 (Disease Ontology:DOID:0110087); VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (mmu:110350); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11907264;12432068;16061793;16229832;21750661;22872234;25428506;29187734;30084848;31219806;34203471;34428180;35820727;36210013;8666668;9373155", "class_list": "", "function": "May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JJF9;B8JJG0;O08822;Q5VI59;Q5VI60;Q5VI61;Q5VI62;Q69Z42;Q8BJL5;Q8BL87;Q8BMC7;Q8BUI9;Q8BXK5;Q9CRR8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0045177 apical part of cell", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060294 cilium movement involved in cell motility;GO:0007507 heart development;GO:0016485 protein processing;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q45VK7-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SUF7-1", "uniprot_id": [ { "id": "Q5SUF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SUF7", "type": "external" } ], "mass": 262833.0, "length": 2381, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha", "gene_name": "Cacna1g", "organism": "Mouse", "refseq_name": "voltage-dependent T-type calcium channel subunit alpha-1G isoform X4", "refseq_ac": [ { "id": "XP_006532133", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532133", "type": "external" } ], "gene_names_uniprotkb": "Cacna1g", "gene_names_refseq": "Cacna1g; Cav3.1d; [a]1G; a1G; alpha-1G; mKIAA1123", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha", "protein_names_refseq": "voltage-dependent T-type calcium channel subunit alpha-1G isoform X4", "tax_id": 10090, "disease": "cerebellar ataxia type 42 (Disease Ontology:DOID:0111742)", "pathway": " (mmu:12291)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21750661;22645316", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the `low-voltage activated (LVA)` group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0097110 scaffold protein binding;GO:0005245 voltage-gated calcium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0008332 low voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042391 regulation of membrane potential;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5SUF7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YYP6-1", "uniprot_id": [ { "id": "A0A0A6YYP6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YYP6", "type": "external" } ], "mass": 44037.0, "length": 397, "protein_name": "Tyrosine-protein phosphatase non-receptor type substrate 1", "gene_name": "Sirpb1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sirpb1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Signal-regulatory protein alpha-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0032675 regulation of interleukin-6 production;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0A6YYP6-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4U2R1-1", "uniprot_id": [ { "id": "HERC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4U2R1", "type": "external" } ], "mass": 527456.0, "length": 4836, "protein_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "Herc2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": [ { "id": "NP_034548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034548", "type": "external" } ], "gene_names_uniprotkb": "Herc2; Jdf2; Kiaa0393; Rjs", "gene_names_refseq": "D15F32S1h; D7H15F32S1; D7H15F37S1; Herc2; jdf2; mKIAA0393; rjs", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HERC2; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2", "protein_names_refseq": "E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; probable E3 ubiquitin-protein ligase HERC2", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 38 (Disease Ontology:DOID:0081203); pigmentation disease (Disease Ontology:DOID:10123)", "pathway": " (mmu:15204); (R-MMU-3108214); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473); (R-MMU-983168)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10441737;17242355;21183079;21750661;25428506;30016717;30084848;31219806;34203471;34418053;34428180;36241744;40021952;9689098;9949213", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Also modulates iron metabolism by regulating the basal turnover of FBXL5., [UniProtKB, UniProtKB]; HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9PZT6;O88473;Q3TRJ8;Q3TS47;Q3TST2;Q3UFQ6;Q3URH7;Q5DU32;Q7TPR5;Q80VV7;Q9QYT1;Q9Z168;Q9Z171", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0032183 SUMO binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q4U2R1-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z4R1-1", "uniprot_id": [ { "id": "HFM1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z4R1", "type": "external" } ], "mass": 161379.0, "length": 1434, "protein_name": "Probable ATP-dependent DNA helicase HFM1", "gene_name": "Hfm1", "organism": "Mouse", "refseq_name": "probable ATP-dependent DNA helicase HFM1 isoform 1", "refseq_ac": [ { "id": "NP_808541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808541", "type": "external" } ], "gene_names_uniprotkb": "Hfm1", "gene_names_refseq": "A330009G12Rik; Gm1046; Hfm1; Mer3; Sec63d1", "protein_names_uniprotkb": "Probable ATP-dependent DNA helicase HFM1; 5.6.2.4; DNA 3'-5' helicase HFM1", "protein_names_refseq": "DNA 3'-5' helicase HFM1; SEC63 domain containing 1; probable ATP-dependent DNA helicase HFM1 isoform 1; probable ATP-dependent DNA helicase HFM1", "tax_id": 10090, "disease": "primary ovarian insufficiency 9 (Disease Ontology:DOID:0080866)", "pathway": " (mmu:330149)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23555294;35526155;38822414", "class_list": "", "function": "Biallelic HFM1 variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degrees., [RefSeq, PubMed]; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis., [UniProtKB, PubMed]; The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice. Publication Status: Online-Only, [RefSeq, PubMed]; We propose that initial steps of recombination are sufficient to support homology recognition, pairing, and initial chromosome synapsis and that HFM1 is required to form normal numbers of COs and to complete synapsis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007283 spermatogenesis;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z4R1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TGF2-1", "uniprot_id": [ { "id": "F107B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TGF2", "type": "external" } ], "mass": 15572.0, "length": 131, "protein_name": "Protein FAM107B", "gene_name": "Fam107b", "organism": "Mouse", "refseq_name": "protein FAM107B isoform 1", "refseq_ac": [ { "id": "NP_079902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079902", "type": "external" } ], "gene_names_uniprotkb": "Fam107b", "gene_names_refseq": "3110001A13Rik; Fam107b; Gm50615", "protein_names_uniprotkb": "Protein FAM107B", "protein_names_refseq": "novel DUF1151 domain containing protein; protein FAM107B isoform 1; protein FAM107B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66540)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19224205;20173027;21750661;23806337;25605945;25637808;30084848;30779550;34428180", "class_list": "", "function": "Fam107B and DRR1 show different spatio-temporal expression patterns in the central nervous system, suggesting at least partially different functional roles in the brain; glucocorticoid receptor-induced regulation appears to be a unique property of DRR1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR82", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TGF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHQ6-1", "uniprot_id": [ { "id": "DOP1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHQ6", "type": "external" } ], "mass": 257483.0, "length": 2295, "protein_name": "Protein DOP1B", "gene_name": "Dop1b", "organism": "Mouse", "refseq_name": "protein DOP1B isoform 2", "refseq_ac": [ { "id": "NP_080976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080976", "type": "external" } ], "gene_names_uniprotkb": "Dop1b; Dopey2; Kiaa0933", "gene_names_refseq": "0610038M01Rik; 2610510B01Rik; C21orf5; Dop1b; Dopey2; mKIAA0933", "protein_names_uniprotkb": "Protein DOP1B", "protein_names_refseq": "dopey family member 2; protein DOP1B isoform 2; protein DOP1B; protein dopey-2", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:70028)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12767918;17242355;18250455;21183079;21750661;30084848;31219806;33300544;34428180;35820727", "class_list": "", "function": "May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLV2;Q3UH78;Q80TN8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0050890 cognition;GO:0006895 Golgi to endosome transport;GO:0009880 embryonic pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UHQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9T0-1", "uniprot_id": [ { "id": "E9Q9T0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9T0", "type": "external" } ], "mass": 110740.0, "length": 1031, "protein_name": "Fibrosin-like 1", "gene_name": "Fbrsl1", "organism": "Mouse", "refseq_name": "fibrosin-1-like protein isoform 1", "refseq_ac": [ { "id": "NP_001136114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136114", "type": "external" } ], "gene_names_uniprotkb": "Fbrsl1", "gene_names_refseq": "2410025L10Rik; Fbrsl1; Gm1049; Gm29766; mKIAA1545", "protein_names_uniprotkb": "Fibrosin-like 1", "protein_names_refseq": "AUTS2-like protein; fibrosin-1-like protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9T0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AWC9-1", "uniprot_id": [ { "id": "B1AWC9_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AWC9", "type": "external" } ], "mass": 83301.0, "length": 736, "protein_name": "Phosphodiesterase", "gene_name": "Pde4b", "organism": "Mouse", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4B isoform 7", "refseq_ac": [ { "id": "NP_001391715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001391715", "type": "external" } ], "gene_names_uniprotkb": "Pde4b", "gene_names_refseq": "Dpde4; Pde4b; dunce", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4B isoform 7", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:18578); (R-MMU-180024)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15345747;21750661;38920631;39256048", "class_list": "", "function": "Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice. Publication Status: Online-Only, [RefSeq, PubMed]; PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:1901898 negative regulation of relaxation of cardiac muscle;GO:0050852 T cell receptor signaling pathway;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1AWC9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8JJD3-1", "uniprot_id": [ { "id": "B8JJD3_MOUSE", "url": "https://www.uniprot.org/uniprot/B8JJD3", "type": "external" } ], "mass": 56942.0, "length": 526, "protein_name": "Fanconi anemia, complementation group E", "gene_name": "Fance", "organism": "Mouse", "refseq_name": "Fanconi anemia group E protein isoform 1", "refseq_ac": [ { "id": "NP_001157291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157291", "type": "external" } ], "gene_names_uniprotkb": "Fance", "gene_names_refseq": "2810451D06Rik; Fance", "protein_names_uniprotkb": "Fanconi anemia, complementation group E", "protein_names_refseq": "Fanconi anemia group E protein isoform 1", "tax_id": 10090, "disease": "Fanconi anemia complementation group E (Disease Ontology:DOID:0111084)", "pathway": " (mmu:72775); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12093742;21750661;26939056;27486799;37563658", "class_list": "", "function": "Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. Publication Status: Online-Only, [RefSeq, PubMed]; Primary ovarian insufficiency is induced by Fance mutation in a mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Results provide evidence that fance protein plays an important, but not absolutely essential, role in the initial developmental expansion of the male germ line. Publication Status: Online-Only, [RefSeq, PubMed]; The fact that defects in the human ortholog result in Fanconi anemia disease suggests that this protein has a critical function and is likely evolutionarily conserved., [RefSeq, PubMed]; This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0036297 interstrand cross-link repair;GO:0001541 ovarian follicle development;GO:0048872 homeostasis of number of cells;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B8JJD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WPN7-1", "uniprot_id": [ { "id": "A0A087WPN7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WPN7", "type": "external" } ], "mass": 11343.0, "length": 100, "protein_name": "Immunoglobulin heavy variable 13-2", "gene_name": "Ighv13-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv13-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 13-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WPN7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K409-1", "uniprot_id": [ { "id": "DPOLB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K409", "type": "external" } ], "mass": 38288.0, "length": 335, "protein_name": "DNA polymerase beta", "gene_name": "Polb", "organism": "Mouse", "refseq_name": "DNA polymerase beta", "refseq_ac": [ { "id": "NP_035260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035260", "type": "external" } ], "gene_names_uniprotkb": "Polb", "gene_names_refseq": "A430088C08Rik; Polb", "protein_names_uniprotkb": "DNA polymerase beta; 2.7.7.7; 4.2.99.-; 4.2.99.18; 5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase", "protein_names_refseq": "5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase; DNA polymerase beta; Pol beta", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:18970); (R-MMU-110362); (R-MMU-110373); (R-MMU-110381); (R-MMU-5649702); (R-MMU-5651801); (R-MMU-5689880); (R-MMU-73930)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "21750661;23806337;25605945;30084848;31219806;34428180;36702010;38245510", "class_list": "", "function": "DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Publication Status: Online-Only, [RefSeq, PubMed]; Polbeta/XRCC1 heterodimerization dictates DNA damage recognition and basal Polbeta protein levels without interfering with mouse viability or fertility., [RefSeq, PubMed]; Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAB6;Q922Z7", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005876 spindle microtubule", "go_biological_process": "GO:0006287 base-excision repair, gap-filling;GO:0001701 in utero embryonic development;GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K409-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFD5-1", "uniprot_id": [ { "id": "DLGP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFD5", "type": "external" } ], "mass": 105873.0, "length": 977, "protein_name": "Disks large-associated protein 3", "gene_name": "Dlgap3", "organism": "Mouse", "refseq_name": "disks large-associated protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001289010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289010", "type": "external" } ], "gene_names_uniprotkb": "Dlgap3; Dap3", "gene_names_refseq": "DAP-3; DAP3; Dlgap3; Prpl8; Sapap3", "protein_names_uniprotkb": "Disks large-associated protein 3; DAP-3; PSD-95/SAP90-binding protein 3; SAP90/PSD-95-associated protein 3; SAPAP3", "protein_names_refseq": "PSD-95/SAP90-binding protein 3; SAP90/PSD 95 associated protein 3; discs, large homolog-associated protein 3; disks large-associated protein 3 isoform 1; prion protein ligand 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:242667); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15024750;16452087;21183079;21750661;22517741;22645316;25428506;30084848;32848054;34678516;39043310;40885482", "class_list": "", "function": "Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour., [RefSeq, PubMed]; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDX0;Q6XBF2", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0001540 amyloid-beta binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0065003 protein-containing complex assembly;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6PFD5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U458-1", "uniprot_id": [ { "id": "DJC11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U458", "type": "external" } ], "mass": 63233.0, "length": 559, "protein_name": "DnaJ homolog subfamily C member 11", "gene_name": "Dnajc11", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 11", "refseq_ac": [ { "id": "NP_766292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766292", "type": "external" } ], "gene_names_uniprotkb": "Dnajc11", "gene_names_refseq": "Dnajc11; E030019A03Rik", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 11", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 11; dnaJ homolog subfamily C member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:230935)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12964007;21183079;21750661;25111180;31550165;33300544", "class_list": "", "function": "A link between DNAJC11 and neuromuscular diseases Publication Status: Online-Only, [RefSeq, PubMed]; E030019A03 is the mouse ortholog of human FLJ10737, consisting of the DnaJ domain, bipartite nuclear localization signal (NLS), FADH domain, and FEMCA domain., [RefSeq, PubMed]; Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice., [RefSeq, PubMed]; Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A8C9;Q8BP83;Q8C1Z4;Q8C6U5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5U458-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQF6-1", "uniprot_id": [ { "id": "DPYL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQF6", "type": "external" } ], "mass": 61516.0, "length": 564, "protein_name": "Dihydropyrimidinase-related protein 5", "gene_name": "Dpysl5", "organism": "Mouse", "refseq_name": "dihydropyrimidinase-related protein 5 isoform a", "refseq_ac": [ { "id": "NP_075534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075534", "type": "external" } ], "gene_names_uniprotkb": "Dpysl5; Crmp5", "gene_names_refseq": "CRAM; CRMP-5; Crmp5; Dpysl5", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 5; CRMP-5; Collapsin response mediator protein 5; DRP-5", "protein_names_refseq": "DRP-5; collapsin response mediator protein 5; dihydropyrimidinase-related protein 5 isoform a; dihydropyrimidinase-related protein 5", "tax_id": 10090, "disease": "Ritscher-Schinzel syndrome (Disease Ontology:DOID:0060565)", "pathway": " (mmu:65254); (R-MMU-399956)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10956643;12581152;15509652;15834957;15926912;21183079;22645316;24129315;31219806;31233825;32848054;33638112;34034836;38047349;40684658;40885482", "class_list": "", "function": "Beyond their signalling function in axon outgrowth and guidance, CRMPs also play a role in mature neurons both in axons and in dendrites, [RefSeq, PubMed]; CRAM regulates filopodial dynamics and growth cone development, thereby restricting the response of growth cone to repulsive guidance cues, [RefSeq, PubMed]; CRMP5 participates in oocyte meiosis by regulating spastin to correct microtubule-kinetochore misconnection., [RefSeq, PubMed]; Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice., [RefSeq, PubMed]; In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons., [RefSeq, PubMed]; Involved in the negative regulation of dendrite outgrowth., [UniProtKB, UniProtKB]; Results suggest that CRMP5 regulates social behavior via modulation of surface GluA2 trafficking and affects memory performance in Alzheimer Disease mice., [RefSeq, PubMed]; Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050774 negative regulation of dendrite morphogenesis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EQF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A699-1", "uniprot_id": [ { "id": "F1712_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A699", "type": "external" } ], "mass": 87487.0, "length": 822, "protein_name": "Protein FAM171A2", "gene_name": "Fam171a2", "organism": "Mouse", "refseq_name": "protein FAM171A2 precursor", "refseq_ac": [ { "id": "NP_954670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954670", "type": "external" } ], "gene_names_uniprotkb": "Fam171a2", "gene_names_refseq": "Fam171a2", "protein_names_uniprotkb": "Protein FAM171A2", "protein_names_refseq": "protein FAM171A2 precursor; protein FAM171A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217219)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;30899004;33300544", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B7ZC48;Q05CH6;Q6P2L1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "A2A699-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXD6-1", "uniprot_id": [ { "id": "F16P1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXD6", "type": "external" } ], "mass": 36912.0, "length": 338, "protein_name": "Fructose-1,6-bisphosphatase 1", "gene_name": "Fbp1", "organism": "Mouse", "refseq_name": "fructose-1,6-bisphosphatase 1 isoform 1", "refseq_ac": [ { "id": "NP_062268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062268", "type": "external" } ], "gene_names_uniprotkb": "Fbp1; Fbp3; Fbp", "gene_names_refseq": "Fbp-2; Fbp1; Fbp2; Fbp3", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase 1; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; FBPase 3; Fructose-1,6-bisphosphatase isozyme 3; Liver FBPase", "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 3; FBPase liver; fructose-1,6-bisphosphatase 1 isoform 1; fructose-1,6-bisphosphatase 1; fructose-1,6-bisphosphatase isozyme 3; liver FBPase", "tax_id": 10090, "disease": "fructose-1,6-bisphosphatase deficiency (Disease Ontology:DOID:5204)", "pathway": " (mmu:14121); (R-MMU-70263)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11250076;16497803;17242355;18375435;20719858;21183079;21750661;23806337;32754266;34428180;37453647;37908738;38834617;9106734", "class_list": "glycogene", "function": "1alpha,25(OH)2D3 ameliorates insulin resistance by alleviating gammadelta T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain., [UniProtKB, PubMed, PubMed, PubMed]; FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97323;Q3UEH1", "ec_number_list": [ { "id": "3.1.3.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.11", "type": "external" } ], "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0097403 cellular response to raffinose;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032869 cellular response to insulin stimulus;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QXD6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP78-1", "uniprot_id": [ { "id": "F10C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP78", "type": "external" } ], "mass": 37202.0, "length": 315, "protein_name": "Protein FRA10AC1 homolog", "gene_name": "Fra10ac1", "organism": "Mouse", "refseq_name": "protein FRA10AC1 homolog isoform 1", "refseq_ac": [ { "id": "NP_001074544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074544", "type": "external" } ], "gene_names_uniprotkb": "Fra10ac1", "gene_names_refseq": "5730455O13Rik; Fra10ac1", "protein_names_uniprotkb": "Protein FRA10AC1 homolog", "protein_names_refseq": "protein FRA10AC1 homolog isoform 1; protein FRA10AC1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70567)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15203205;17242355;21183079;23806337", "class_list": "", "function": "May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VPM5;Q1LZ54;Q3T9W6", "ec_number_list": [], "go_molecular_function": "GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BP78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHC9-1", "uniprot_id": [ { "id": "ELF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHC9", "type": "external" } ], "mass": 63203.0, "length": 593, "protein_name": "ETS-related transcription factor Elf-2", "gene_name": "Elf2", "organism": "Mouse", "refseq_name": "ETS-related transcription factor Elf-2 isoform 2", "refseq_ac": [ { "id": "NP_001277988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277988", "type": "external" } ], "gene_names_uniprotkb": "Elf2; Nerf", "gene_names_refseq": "2610036A20Rik; A230104O07Rik; EU32; Elf2; NERF-1A; NERF-1B; NERF-2; NERF", "protein_names_uniprotkb": "ETS-related transcription factor Elf-2; E74-like factor 2; New ETS-related factor", "protein_names_refseq": "ETS-related transcription factor Elf-2 isoform 2; ETS-related transcription factor Elf-2; ets domain transcription factor; ets family transcription factor ELF2A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69257); (R-MMU-8939245)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "20173027;21183079;21606357;21750661;22517741;22645316;24129315;25428506;29237092;31219806;32782141;32848054;35820727;36084651;36852467;40885482;9001422", "class_list": "", "function": "Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q6NST2;Q8BTX8;Q9JHC7;Q9JHC8;Q9JHD0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9JHC9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35387-1", "uniprot_id": [ { "id": "HAX1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35387", "type": "external" } ], "mass": 31654.0, "length": 280, "protein_name": "HCLS1-associated protein X-1", "gene_name": "Hax1", "organism": "Mouse", "refseq_name": "HCLS1-associated protein X-1 isoform 1", "refseq_ac": [ { "id": "NP_035956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035956", "type": "external" } ], "gene_names_uniprotkb": "Hax1; Hs1bp1", "gene_names_refseq": "HAX-1; HSP1BP-1; Hax1; Hs1bp1; SIG-111; Silg111; mHAX-1s", "protein_names_uniprotkb": "HCLS1-associated protein X-1; HAX-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1", "protein_names_refseq": "HCLS1-associated protein X-1 isoform 1; HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); severe congenital neutropenia 3 (Disease Ontology:DOID:0112133)", "pathway": " (mmu:23897)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10760273;16814492;18288109;21750661;26915802;26997484;32079675;33600816;33741962;35379774", "class_list": "", "function": "Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance. Publication Status: Online-Only, [RefSeq, PubMed]; Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export., [RefSeq, PubMed]; Neuroprotective roles of HAX-1 in ischemic neuronal injury., [RefSeq, PubMed]; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542F8", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0019966 interleukin-1 binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35387-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BY71-1", "uniprot_id": [ { "id": "HAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BY71", "type": "external" } ], "mass": 49278.0, "length": 416, "protein_name": "Histone acetyltransferase type B catalytic subunit", "gene_name": "Hat1", "organism": "Mouse", "refseq_name": "histone acetyltransferase type B catalytic subunit", "refseq_ac": [ { "id": "NP_080391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080391", "type": "external" } ], "gene_names_uniprotkb": "Hat1", "gene_names_refseq": "2410071B14Rik; Hat-1; Hat1; KAT1", "protein_names_uniprotkb": "Histone acetyltransferase type B catalytic subunit; 2.3.1.-; 2.3.1.48; Histone acetyltransferase 1; Histone methacryltransferase HAT1", "protein_names_refseq": "histidine aminotransferase 1; histone acetyltransferase 1; histone acetyltransferase type B catalytic subunit; histone methacryltransferase HAT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107435); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;23548937;23754951;23806337;25153642;31695772;32366460;34098071;34428180;37907924", "class_list": "", "function": "Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging. Publication Status: Online-Only, [RefSeq, PubMed]; Expression levels of Hat1 promoter mRNA are not significantly different in vitrified oocyte promoter compared with fresh oocytes., [RefSeq, PubMed]; HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome. Publication Status: Online-Only, [RefSeq, PubMed]; Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly., [RefSeq, PubMed]; Histone acetyltransferase 1 is required for DNA replication fork function and stability., [RefSeq, PubMed]; Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0042393 histone binding;GO:0010485 histone H4 acetyltransferase activity;GO:0140218 histone methacryltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016363 nuclear matrix;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BY71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0S6-1", "uniprot_id": [ { "id": "H2AZ_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C0S6", "type": "external" } ], "mass": 13553.0, "length": 128, "protein_name": "Histone H2A.Z", "gene_name": "H2az1", "organism": "Mouse", "refseq_name": "histone H2A.Z isoform 1", "refseq_ac": [ { "id": "NP_058030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058030", "type": "external" } ], "gene_names_uniprotkb": "H2az1; H2afz; H2az", "gene_names_refseq": "H2A.Z1; H2A.Z; H2a.z-1; H2afz; H2az1", "protein_names_uniprotkb": "Histone H2A.Z; H2A/z", "protein_names_refseq": "H2A histone family, member Z; histone H2A.Z isoform 1; histone H2A.Z", "tax_id": 10090, "disease": "", "pathway": " (mmu:51788)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11516949;12660166;15195148;15546624;16204459;21750661;30842416;31645732;32542325;33725478;34428180;35820727;35984892;37507081;37828378;7217105", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXZ3;P17317;Q3UA55;Q3UK43;Q68FD2", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0071392 cellular response to estradiol stimulus;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P0C0S6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04441-1", "uniprot_id": [ { "id": "HG2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P04441", "type": "external" } ], "mass": 31557.0, "length": 279, "protein_name": "H-2 class II histocompatibility antigen gamma chain", "gene_name": "Cd74", "organism": "Mouse", "refseq_name": "H-2 class II histocompatibility antigen gamma chain isoform 1", "refseq_ac": [ { "id": "NP_001036070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036070", "type": "external" } ], "gene_names_uniprotkb": "Cd74; Ii", "gene_names_refseq": "CLIP; Cd74; DHLAG; HLADG; Ia-GAMMA; Ii", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen gamma chain; Ia antigen-associated invariant chain; Ii chain; Ii; MHC class II-associated invariant chain", "protein_names_refseq": "H-2 class II histocompatibility antigen gamma chain isoform 1; H-2 class II histocompatibility antigen gamma chain; HLA-DR-GAMMA; Ia-associated invariant chain; MHC class II-associated invariant chain; class II-associated invariant chain peptide; dinucleotide microsatellite; histocompatibility: class II antigens, gamma chain of; ia antigen-associated invariant chain; ii chain; invariant polypeptide of major histocompatibility complex, class II antigen-associated", "tax_id": 10090, "disease": "", "pathway": " (mmu:16149); (R-MMU-202733); (R-MMU-2132295)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;11465105;11483509;12417635;1319610;16075062;16393994;1656276;18250455;19144319;19224205;20173027;2111346;21913724;2492095;26495903;26740625;28011936;29255075;30084848;3038530;31599954;32152506;32855215;3422739;34428180;37828378;6327293;8343954;8977190", "class_list": "glycogene", "function": "Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome., [UniProtKB, UniProtKB]; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44., [UniProtKB, PubMed, PubMed]; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O19452", "ec_number_list": [], "go_molecular_function": "GO:0035718 macrophage migration inhibitory factor binding;GO:0001540 amyloid-beta binding;GO:0023026 MHC class II protein complex binding;GO:0042609 CD4 receptor binding;GO:0050998 nitric-oxide synthase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0006886 intracellular protein transport;GO:0006952 defense response;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P04441-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U0D9-1", "uniprot_id": [ { "id": "HACE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U0D9", "type": "external" } ], "mass": 102114.0, "length": 909, "protein_name": "E3 ubiquitin-protein ligase HACE1", "gene_name": "Hace1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HACE1", "refseq_ac": [ { "id": "NP_766061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766061", "type": "external" } ], "gene_names_uniprotkb": "Hace1; Kiaa1320", "gene_names_refseq": "1700042J16Rik; A730034A22Rik; Hace1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HACE1; 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1", "protein_names_refseq": "E3 ubiquitin-protein ligase HACE1; HECT-type E3 ubiquitin transferase HACE1", "tax_id": 10090, "disease": "", "pathway": " (mmu:209462); (R-MMU-983168); (R-MMU-9958825)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "17694067;19350571;21750661;22872234;23864022;25428506;29121340;31219806;32366477;33603169;34203471;34428180;36210013;37828378;37846480;38332367", "class_list": "", "function": "Authors show that the genetic ablation of hace1 in the YAC128 mouse model of HD accelerates motor deficits and exacerbates cognitive and psychiatric phenotypes in vivo., [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (By similarity). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (By similarity). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (By similarity). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB (PubMed:19350571)., [UniProtKB, PubMed, UniProtKB]; HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases., [RefSeq, PubMed]; HACE1 blocks HIF1alpha accumulation under hypoxia in a RAC1 dependent manner., [RefSeq, PubMed]; Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes., [RefSeq, PubMed]; The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6VQI5;F7ALT5;Q5DTY7;Q8BXY2;Q8R160;Q8R3G4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0030334 regulation of cell migration;GO:0061025 membrane fusion;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3U0D9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60848-1", "uniprot_id": [ { "id": "HELLS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60848", "type": "external" } ], "mass": 95126.0, "length": 821, "protein_name": "Lymphocyte-specific helicase", "gene_name": "Hells", "organism": "Mouse", "refseq_name": "lymphocyte-specific helicase", "refseq_ac": [ { "id": "NP_032260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032260", "type": "external" } ], "gene_names_uniprotkb": "Hells; Lsh; Pasg", "gene_names_refseq": "E130115I21Rik; Hells; LSH; Lysh; PASG; YFK8", "protein_names_uniprotkb": "Lymphocyte-specific helicase; 3.6.4.-; Proliferation-associated SNF2-like protein", "protein_names_refseq": "lymphocyte-specific helicase; proliferation-associated SNF2-like protein", "tax_id": 10090, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome 4 (Disease Ontology:DOID:0090011); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:15201)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10781083;11325543;11357197;11711429;14517253;14612388;15105378;15647320;18299400;21183079;21750661;21952136;22946062;25428506;25428507;25605945;27802388;28528544;30084848;30779550;32001511;33159050;33649389;34428180;35820727;36194437;37709749;39627609;8647447;9878251", "class_list": "", "function": "ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications (PubMed:11711429, PubMed:14517253). It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements (PubMed:14517253, PubMed:14612388, PubMed:15647320, PubMed:37709749). Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection (PubMed:22946062). During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening (PubMed:32001511). Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability (PubMed:11325543, PubMed:11357197, PubMed:15105378). Involved in regulation of the expansion or survival of lymphoid cells (PubMed:10781083, PubMed:37709749, PubMed:8647447)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells. Publication Status: Online-Only, [RefSeq, PubMed]; LSH mediates gene repression through macroH2A deposition. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497T3;Q8VDZ1;Q9CYV7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0035861 site of double-strand break;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q60848-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640R3-1", "uniprot_id": [ { "id": "HECAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640R3", "type": "external" } ], "mass": 46367.0, "length": 418, "protein_name": "Hepatic and glial cell adhesion molecule", "gene_name": "Hepacam", "organism": "Mouse", "refseq_name": "hepatic and glial cell adhesion molecule precursor", "refseq_ac": [ { "id": "NP_780398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780398", "type": "external" } ], "gene_names_uniprotkb": "Hepacam", "gene_names_refseq": "2900042E01Rik; Glialcam; Hepacam; Hepn1", "protein_names_uniprotkb": "Hepatic and glial cell adhesion molecule; Hepatocyte cell adhesion molecule; Protein hepaCAM; glialCAM", "protein_names_refseq": "hepatic and glial cell adhesion molecule precursor; hepatic and glial cell adhesion molecule; protein hepaCAM", "tax_id": 10090, "disease": "megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); megalencephalic leukoencephalopathy with subcortical cysts 2B (Disease Ontology:DOID:0080317); megalencephalic leukoencephalopathy with subcortical cysts 2A (Disease Ontology:DOID:0080318)", "pathway": " (mmu:72927)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17114649;18293412;21183079;21750661;22405205;22645316;30899004;32848054;33300544;34171291;37620511;40021952;40885482", "class_list": "", "function": "Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation. Publication Status: Online-Only, [RefSeq, PubMed]; GlialCAM, an immunoglobulin-like cell adhesion molecule is expressed in glial cells of the central nervous system., [RefSeq, PubMed]; HepaCAM controls astrocyte self-organization and coupling., [RefSeq, PubMed]; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 24, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0097450 astrocyte end-foot", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q640R3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TS99-1", "uniprot_id": [ { "id": "HELT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TS99", "type": "external" } ], "mass": 26973.0, "length": 240, "protein_name": "Hairy and enhancer of split-related protein HELT", "gene_name": "Helt", "organism": "Mouse", "refseq_name": "hairy and enhancer of split-related protein HELT", "refseq_ac": [ { "id": "NP_776150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776150", "type": "external" } ], "gene_names_uniprotkb": "Helt; Hesl; Mgn", "gene_names_refseq": "A830086M02; Helt; Heslike; Hesl; Mgn; megane", "protein_names_uniprotkb": "Hairy and enhancer of split-related protein HELT; HES/HEY-like transcription factor; Protein Hes-like; Protein megane", "protein_names_refseq": "HES/HEY-like transcription factor; Hes-like transcription factor; bHLH transcription factor megane; hairy and enhancer of split-related protein HELT; mesencephalic GABAergic neurons enhancer of split related protein; protein megane", "tax_id": 10090, "disease": "", "pathway": " (mmu:234219)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14764602;15071116;16644143;16968817;17611227;23576753;31219806", "class_list": "", "function": "Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity, [RefSeq, PubMed]; Homozygous Mgn-null mice die between the second and the fifth postnatal week of age, and show a complete depletion of Gad65 and Gad67 expression in the superior colliculus and a reduction in the inferior colliculus., [RefSeq, PubMed]; Identification of a novel mouse bHLH factor, termed Heslike, that has Hes1-like bHLH domain and transcriptional repressor activity; Heslike is coexpressed with the bHLH factor Mash1 in brain regions that give rise to GABAergic neurons, [RefSeq, PubMed]; Mgn is a single copy gene on mouse chromosome 8 and encodes a 27kDa protein that functions in the nucleus., [RefSeq, PubMed]; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TS99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Z4-1", "uniprot_id": [ { "id": "HEPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0Z4", "type": "external" } ], "mass": 129666.0, "length": 1157, "protein_name": "Hephaestin", "gene_name": "Heph", "organism": "Mouse", "refseq_name": "hephaestin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001153099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153099", "type": "external" } ], "gene_names_uniprotkb": "Heph; Kiaa0698", "gene_names_refseq": "C130006F04Rik; Cpl; Heph; Hp; mKIAA0698; sla", "protein_names_uniprotkb": "Hephaestin; 1.16.3.1; Hp", "protein_names_refseq": "haphaestin; hephaestin isoform 1 precursor; sex linked anemia", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:15203); (R-MMU-425410); (R-MMU-917937)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14751926;21183079;21750661;30084848;30182051;30647129;9988272", "class_list": "", "function": "HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution. Publication Status: Online-Only, [RefSeq, PubMed]; Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form (PubMed:14751926). Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (PubMed:14751926, PubMed:30647129, PubMed:9988272)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AI63;Q6ZQ65;Q80Y80;Q8C4S2", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006826 iron ion transport;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0160179 intestinal iron absorption;GO:1904040 positive regulation of iron export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z0Z4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z130-1", "uniprot_id": [ { "id": "HNRDL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z130", "type": "external" } ], "mass": 33559.0, "length": 301, "protein_name": "Heterogeneous nuclear ribonucleoprotein D-like", "gene_name": "Hnrnpdl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hnrnpdl; Hnrnpdl1; Hnrpdl; Jktbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein D-like; JKT41-binding protein; hnRNP D-like; hnRNP DL", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306)", "pathway": " (mmu:50926)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10717477;15190078;21750661;24129315;33300544;34428180", "class_list": "", "function": "Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers (By similarity). Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity)., [UniProtKB, PubMed]; Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CT01", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0000785 chromatin", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z130-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49710-1", "uniprot_id": [ { "id": "HCLS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P49710", "type": "external" } ], "mass": 54240.0, "length": 486, "protein_name": "Hematopoietic lineage cell-specific protein", "gene_name": "Hcls1", "organism": "Mouse", "refseq_name": "hematopoietic lineage cell-specific protein", "refseq_ac": [ { "id": "NP_032251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032251", "type": "external" } ], "gene_names_uniprotkb": "Hcls1; Hs1", "gene_names_refseq": "HS1; Hcls1", "protein_names_uniprotkb": "Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1", "protein_names_refseq": "hematopoietic cell-specific LYN substrate 1; hematopoietic lineage cell-specific protein; lckBP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15163)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10590261;17947660;19001085;19064729;21183079;21750661;23017497;26495903;27281784;28122813;28678266;31219806;7535527;7628441;8943564", "class_list": "", "function": "HS1 and Arp2/3 complex-mediated actin polymerization are essential for the most efficient dendritic cell random migration and force generation., [RefSeq, PubMed]; HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation., [RefSeq, PubMed]; Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors., [RefSeq, PubMed]; Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity., [RefSeq, PubMed]; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922I8", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0042307 positive regulation of protein import into nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P49710-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7X6-1", "uniprot_id": [ { "id": "HEG1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7X6", "type": "external" } ], "mass": 141899.0, "length": 1337, "protein_name": "Protein HEG homolog 1", "gene_name": "Heg1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Heg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein HEG homolog 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:77446)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19151727;21183079;21750661;34428180;35820727", "class_list": "", "function": "Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR26;Q6GQS6;Q8CED0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "E9Q7X6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R081-1", "uniprot_id": [ { "id": "HNRPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R081", "type": "external" } ], "mass": 63964.0, "length": 586, "protein_name": "Heterogeneous nuclear ribonucleoprotein L", "gene_name": "Hnrnpl", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein L isoform b", "refseq_ac": [ { "id": "NP_796275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796275", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpl; Hnrpl", "gene_names_refseq": "D830027H13Rik; Hnrnpl; Hnrpl", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein L; hnRNP L", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein L isoform b; hnRNP L", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); systemic scleroderma (Disease Ontology:DOID:418); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15388); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "12130696;18250455;21183079;21750661;22523384;22645316;24129315;25428506;28315936;33300544;34428180;34887587;35820727;36537238;37453647;37828378;38744970;39627609;40684658", "class_list": "", "function": "Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation., [RefSeq, PubMed]; Inflammation modulates the interaction of hnRNP I and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA, [RefSeq, PubMed]; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54789;Q499X2;Q8K0S7", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0045892 negative regulation of DNA-templated transcription;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0045727 positive regulation of translation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R081-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70507-1", "uniprot_id": [ { "id": "HCN4_MOUSE", "url": "https://www.uniprot.org/uniprot/O70507", "type": "external" } ], "mass": 129065.0, "length": 1201, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "gene_name": "Hcn4", "organism": "Mouse", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "refseq_ac": [ { "id": "NP_001074661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074661", "type": "external" } ], "gene_names_uniprotkb": "Hcn4; Bcng3", "gene_names_refseq": "Bcng3; Hcn3; Hcn4", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; BCNG-3; Brain cyclic nucleotide-gated channel 3", "protein_names_refseq": "brain cyclic nucleotide-gated channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4", "tax_id": 10090, "disease": "Brugada syndrome 8 (Disease Ontology:DOID:0110225); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sick sinus syndrome (Disease Ontology:DOID:13884); generalized epilepsy (Disease Ontology:DOID:1827)", "pathway": " (mmu:330953); (R-MMU-1296061)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11675786;14643687;14657344;17114649;21183079;21220308;22645316;22715094;25428506;32647060;40885482;9630217", "class_list": "", "function": "Gene expression of HCN4 during mouse heart development., [RefSeq, PubMed]; HCN4 channels are essential for the proper generation of pacemaker potentials in the emerging sinoatrial node, [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions (By similarity). Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (PubMed:14657344, PubMed:21220308). Contributes to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli (PubMed:11675786)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RY58", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0086091 regulation of heart rate by cardiac conduction;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O70507-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10518-1", "uniprot_id": [ { "id": "HEM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P10518", "type": "external" } ], "mass": 36024.0, "length": 330, "protein_name": "Delta-aminolevulinic acid dehydratase", "gene_name": "Alad", "organism": "Mouse", "refseq_name": "delta-aminolevulinic acid dehydratase", "refseq_ac": [ { "id": "NP_001263375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263375", "type": "external" } ], "gene_names_uniprotkb": "Alad; Lv", "gene_names_refseq": "ALADH; Alad; Lv", "protein_names_uniprotkb": "Delta-aminolevulinic acid dehydratase; 4.2.1.24; ALADH; Porphobilinogen synthase", "protein_names_refseq": "delta-aminolevulinic acid dehydratase; porphobilinogen synthase", "tax_id": 10090, "disease": "sickle cell anemia (Disease Ontology:DOID:10923); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); porphyria cutanea tarda (Disease Ontology:DOID:3132); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:17025); (R-MMU-189451); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "17242355;21183079;23056320;23806337;25428506;26495903;27650074;2922298;30084848;31219806;34428180;4981581", "class_list": "", "function": "Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen., [UniProtKB, PubMed]; Similar to its role at the beta-globin promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner, [RefSeq, PubMed]; This study demonstrated for the first time the involvement of striatal delta-ALA-D activity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and its correlation with the MPO activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THV6", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0032791 lead ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004655 porphobilinogen synthase activity;GO:1904854 proteasome core complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006979 response to oxidative stress;GO:0007584 response to nutrient;GO:0010043 response to zinc ion;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P10518-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17095-2", "uniprot_id": [ { "id": "HMGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17095", "type": "external" } ], "mass": 11614.0, "length": 107, "protein_name": "High mobility group protein HMG-I/HMG-Y", "gene_name": "Hmga1", "organism": "Mouse", "refseq_name": "high mobility group protein HMG-I/HMG-Y isoform a", "refseq_ac": [ { "id": "NP_001020598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020598", "type": "external" } ], "gene_names_uniprotkb": "Hmga1; Hmgiy; Hmgi", "gene_names_refseq": "Hmga1a; Hmga1b; Hmga1; Hmgiy; Hmgi; Hmgy", "protein_names_uniprotkb": "High mobility group protein HMG-I/HMG-Y; HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1", "protein_names_refseq": "high mobility group AT-hook protein 1; high mobility group protein A1; high mobility group protein HMG-I/HMG-Y isoform a; high mobility group protein HMG-I/HMG-Y; high mobility group protein I", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); uterine cancer (Disease Ontology:DOID:363); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:111241); (mmu:15361); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11410365;11593421;1429598;16452087;17242355;17525332;17622165;18630941;19131326;21183079;23806337;31219806;3192537;33725478;34428180;38430408", "class_list": "", "function": "HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions., [UniProtKB]; HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy., [RefSeq, PubMed]; This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WV2;Q924L7;Q924L8", "ec_number_list": [], "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030878 thyroid gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003016 respiratory system process;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P17095-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49698-1", "uniprot_id": [ { "id": "HNF4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P49698", "type": "external" } ], "mass": 52684.0, "length": 474, "protein_name": "Hepatocyte nuclear factor 4-alpha", "gene_name": "Hnf4a", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 4-alpha isoform HNF4alpha2", "refseq_ac": [ { "id": "NP_032287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032287", "type": "external" } ], "gene_names_uniprotkb": "Hnf4a; Hnf-4; Hnf4; Nr2a1; Tcf14", "gene_names_refseq": "HNF-4; Hnf4alpha; Hnf4a; Hnf4; MODY1; Nr2a1; TCF-14; Tcf14", "protein_names_uniprotkb": "Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; TCF-14; Transcription factor 14; Transcription factor HNF-4", "protein_names_refseq": "HNF4 alpha; Nuclear receptor 2A1; hepatocyte nuclear factor 4-alpha isoform HNF4alpha2; hepatocyte nuclear factor 4-alpha; nuclear receptor subfamily 2 group A member 1; transcription factor 14; transcription factor HNF-4", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); Fanconi renotubular syndrome 4 (Disease Ontology:DOID:0080760); maturity-onset diabetes of the young type 1 (Disease Ontology:DOID:0111099); Fanconi syndrome (Disease Ontology:DOID:1062); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcohol use disorder (Disease Ontology:DOID:1574); glaucoma (Disease Ontology:DOID:1686); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:15378); (R-MMU-383280)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16670015;17242355;17407387;20159955;21183079;21750661;28751364;30530698;30555544;34428180;7999795", "class_list": "", "function": "The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]., [RefSeq]; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5I5;A2ICH0;Q3UNX3;Q8CFY1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005102 signaling receptor binding;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49698-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1F6-1", "uniprot_id": [ { "id": "HID1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1F6", "type": "external" } ], "mass": 88779.0, "length": 788, "protein_name": "Protein HID1", "gene_name": "Hid1", "organism": "Mouse", "refseq_name": "protein HID1 isoform 1", "refseq_ac": [ { "id": "NP_780663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780663", "type": "external" } ], "gene_names_uniprotkb": "Hid1", "gene_names_refseq": "C630004H02Rik; Hid1", "protein_names_uniprotkb": "Protein HID1; HID1 domain-containing protein; Protein hid-1 homolog", "protein_names_refseq": "HID1 domain-containing protein; UPF0663 transmembrane protein C17orf28 homolog; protein HID1 isoform 1; protein HID1; protein hid-1 homolog", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 105 (Disease Ontology:DOID:0070391)", "pathway": " (mmu:217310)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;27751232;34428180;36210013;37828378", "class_list": "", "function": "Plays a role in the biogenesis of large dense core vesicles (LDCVs) at the trans-Golgi network; necessary for the proper sorting of cargo into LDCVs and is required for proper regulated exocytosis (also known as regulated secretory pathway)., [UniProtKB, UniProtKB]; The authors demonstrate that HID-1 deficiency prevented secretory granule maturation by blocking homotypic fusion of immature secretory granules. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A6S8;Q8C8V6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0009749 response to glucose;GO:0030070 insulin processing;GO:0061792 secretory granule maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R1F6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88844-1", "uniprot_id": [ { "id": "IDHC_MOUSE", "url": "https://www.uniprot.org/uniprot/O88844", "type": "external" } ], "mass": 46674.0, "length": 414, "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic", "gene_name": "Idh1", "organism": "Mouse", "refseq_name": "isocitrate dehydrogenase [NADP] cytoplasmic", "refseq_ac": [ { "id": "NP_001104790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104790", "type": "external" } ], "gene_names_uniprotkb": "Idh1", "gene_names_refseq": "E030024J03Rik; Id-1; Idh-1; Idh1; Idpc", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP] cytoplasmic; 1.1.1.42; Cytosolic NADP-isocitrate dehydrogenase; IDH1; IDH; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "IDH; IDP; NADP(+)-specific ICDH; cytosolic NADP-isocitrate dehydrogenase; isocitrate dehydrogenase [NADP] cytoplasmic; oxalosuccinate decarboxylase", "tax_id": 10090, "disease": "D-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050575); myelodysplastic syndrome (Disease Ontology:DOID:0050908); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); autoimmune disease (Disease Ontology:DOID:417); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:15926); (R-MMU-389542); (R-MMU-6798695); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12031902;21183079;21750661;23576753;23806337;28135057;29923039;34428180;37453647;37507081;9866202", "class_list": "", "function": "Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:12031902, PubMed:29923039). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:12031902). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAV7", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O88844-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2V5-1", "uniprot_id": [ { "id": "HDAC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2V5", "type": "external" } ], "mass": 125787.0, "length": 1149, "protein_name": "Protein deacetylase HDAC6", "gene_name": "Hdac6", "organism": "Mouse", "refseq_name": "protein deacetylase HDAC6 isoform 2", "refseq_ac": [ { "id": "NP_001123888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123888", "type": "external" } ], "gene_names_uniprotkb": "Hdac6", "gene_names_refseq": "Hd6; Hdac5; Hdac6; Sfc6; mHDA2", "protein_names_uniprotkb": "Protein deacetylase HDAC6; 3.5.1.-; Tubulin-lysine deacetylase HDAC6; mHDA2", "protein_names_refseq": "histone deacetylase 5; histone deacetylase mHDA2; protein deacetylase HDAC6 isoform 2; protein deacetylase HDAC6; scurfy candidate 6; tubulin-lysine deacetylase HDAC6", "tax_id": 10090, "disease": "polycystic liver disease 1 (Disease Ontology:DOID:0060980); polycystic kidney disease (Disease Ontology:DOID:0080322); chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (Disease Ontology:DOID:0112106); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); cholangiocarcinoma (Disease Ontology:DOID:4947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15185); (R-MMU-3371511); (R-MMU-350054); (R-MMU-5620920); (R-MMU-9646399)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10873806;11533236;12486003;12606581;16933150;19893491;20675388;21183079;21750661;22645316;22819792;24129315;25428506;26746851;27737934;30084848;30779550;31219806;32848054;34428180;35075301;35822049;35922041;36757814;39412062;9891014", "class_list": "", "function": "Deacetylates a wide range of non-histone substrates (PubMed:12606581, PubMed:19893491, PubMed:26746851, PubMed:27737934, PubMed:35075301). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:19893491, PubMed:27737934, PubMed:12606581). Required for cilia disassembly via deacetylation of alpha-tubulin (By similarity). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (PubMed:12486003). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). Deacetylates SQSTM1 (By similarity). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (By similarity). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (PubMed:26746851). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (By similarity). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (By similarity). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (By similarity). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (By similarity). Deacetylates PRDM16 (PubMed:35075301). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (PubMed:35922041). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:22819792)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AUA6", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0090044 positive regulation of tubulin deacetylation;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0016241 regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9Z2V5-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63961-1", "uniprot_id": [ { "id": "EGLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63961", "type": "external" } ], "mass": 70021.0, "length": 653, "protein_name": "Endoglin", "gene_name": "Eng", "organism": "Mouse", "refseq_name": "endoglin isoform 1 precursor", "refseq_ac": [ { "id": "NP_031958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031958", "type": "external" } ], "gene_names_uniprotkb": "Eng; Edg", "gene_names_refseq": "CD105; Endo; Eng; S-endoglin", "protein_names_uniprotkb": "Endoglin; Cell surface MJ7/18 antigen", "protein_names_refseq": "cell surface MJ7/18 antigen; endoglin isoform 1 precursor; transmembrane glycoprotein", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); arteriovenous malformation (Disease Ontology:DOID:11294); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); cholestasis (Disease Ontology:DOID:13580); breast cancer (Disease Ontology:DOID:1612); coronary artery disease (Disease Ontology:DOID:3393); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13805)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10625534;17540773;20042635;21737454;21750661;23300529;28530658;31599954;34428180;8125301;8194490", "class_list": "", "function": "Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 19, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q61520;Q8K100", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0030546 signaling receptor activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q63961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811D0-1", "uniprot_id": [ { "id": "DLG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811D0", "type": "external" } ], "mass": 100120.0, "length": 905, "protein_name": "Disks large homolog 1", "gene_name": "Dlg1", "organism": "Mouse", "refseq_name": "disks large homolog 1 isoform 2", "refseq_ac": [ { "id": "NP_001239362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239362", "type": "external" } ], "gene_names_uniprotkb": "Dlg1; Dlgh1", "gene_names_refseq": "B130052P05Rik; Dlg1; Dlgh1; E-dlg/SAP97; SAP-97; SAP97; mKIAA4187", "protein_names_uniprotkb": "Disks large homolog 1; E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; SAP-97; SAP97; Synapse-associated protein 97", "protein_names_refseq": "discs, large homolog 1; disks large homolog 1 isoform 2; disks large homolog 1; embryo-dlg/synapse-associated protein 97", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:13383); (R-MMU-399719); (R-MMU-438066); (R-MMU-451308); (R-MMU-5673001); (R-MMU-8849932)", "pathway_count": 6, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;11238884;14988405;15277200;16519681;17242355;18034455;21183079;21750661;23676497;24129315;25428506;25558062;28528544;29758280;30084848;30779550;31219806;31599954;34428180;36596415;37828378;40885482;8638125;8922391;9434093", "class_list": "", "function": "Essential multidomain scaffolding protein required for normal development (PubMed:11238884). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)., [UniProtKB, PubMed, PubMed, UniProtKB]; Involvement of SAP97 anchored multiprotein complexes in regulating cardiorenal signaling and trafficking networks. Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q62402;Q6PGB5;Q8CGN7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031579 membrane raft organization;GO:0030432 peristalsis;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0048729 tissue morphogenesis;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q811D0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LIS8-1", "uniprot_id": [ { "id": "A0A140LIS8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LIS8", "type": "external" } ], "mass": 37840.0, "length": 335, "protein_name": "Dehydrogenase/reductase 7 like 1", "gene_name": "Dhrs7l", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase 7 like 1", "refseq_ac": [ { "id": "NP_001423196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423196", "type": "external" } ], "gene_names_uniprotkb": "Dhrs7l; Gm4756", "gene_names_refseq": "Dhrs7l; EG209183; Gm4756", "protein_names_uniprotkb": "Dehydrogenase/reductase 7 like 1", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7 like 1; dehydrogenase/reductase 7 like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:209183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LIS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6R2-1", "uniprot_id": [ { "id": "IDH3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6R2", "type": "external" } ], "mass": 39639.0, "length": 366, "protein_name": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "gene_name": "Idh3a", "organism": "Mouse", "refseq_name": "isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083849", "type": "external" } ], "gene_names_uniprotkb": "Idh3a", "gene_names_refseq": "1110003P10Rik; 1500012E04Rik; Idh3a", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; 1.1.1.41; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha", "protein_names_refseq": "NAD(+)-specific ICDH subunit alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; isocitric dehydrogenase subunit alpha", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 90 (Disease Ontology:DOID:0112147); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (mmu:67834); (R-MMU-71403); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;23576753;23806337;26495903;30478029;33300544;33986196;35820727;36288343;37453647;37507081;37828378;39927985", "class_list": "", "function": "Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-9-5p regulates immunometabolic and epigenetic pathways in beta-glucan-trained immunity via IDH3alpha. Erratum:[JCI Insight. 2022 Mar 22;7(6):e159640. doi: 10.1172/jci.insight.159640. PMID: 35315365] Publication Status: Online-Only, [RefSeq, PubMed]; The role of IDH3 in retinal disease and mitochondrial function, was investigated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAM8;Q8C8A1;Q9D1L1", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9D6R2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D666-1", "uniprot_id": [ { "id": "SUN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D666", "type": "external" } ], "mass": 101976.0, "length": 913, "protein_name": "SUN domain-containing protein 1", "gene_name": "Sun1", "organism": "Mouse", "refseq_name": "SUN domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001243044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243044", "type": "external" } ], "gene_names_uniprotkb": "Sun1; Unc84a", "gene_names_refseq": "4632417G13Rik; 5730434D03Rik; Sun1; Unc84a; mKIAA0810", "protein_names_uniprotkb": "SUN domain-containing protein 1; Protein unc-84 homolog A; Sad1/unc-84 protein-like 1", "protein_names_refseq": "SUN domain-containing protein 1 isoform 2; SUN domain-containing protein 1; protein unc-84 homolog A; sad1/unc-84 protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77053)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;11593002;12036294;16380439;16648470;17132086;17543860;17724119;18845190;19211677;19509342;19841137;19843581;19874786;19933576;20711465;21183079;21750661;21966565;22826121;23348741;24062341;24413433;25892231;26842404;27025256;29878215;30899004;34428180;34678516;34887587;36989130;40997131", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:16380439, PubMed:20711465, PubMed:24062341, PubMed:25892231, PubMed:26842404). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:19874786). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (PubMed:19874786). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (PubMed:17543860, PubMed:19211677, PubMed:19509342, PubMed:24062341, PubMed:25892231, PubMed:26842404). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (PubMed:17543860). Helps to define the distribution of nuclear pore complexes (NPCs) (PubMed:17724119). Required for efficient localization of SYNE4 in the nuclear envelope (PubMed:23348741). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (PubMed:20711465). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Isoform 5 may be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN1 isoform 5:SYNE3 LINC complex may tether spermatid nuclei to anterior cytoskeletal structures such as actin filaments present at membraneous junctions of spermatids and Sertoli cells., [UniProtKB, PubMed]; Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3Z0V9;Q3TIW3;Q3TV96;Q6B4H0;Q80SU8;Q8BZ99;Q99P23", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity;GO:0005521 lamin binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0090292 nuclear matrix anchoring at nuclear membrane;GO:0007283 spermatogenesis;GO:0006998 nuclear envelope organization;GO:0070197 meiotic attachment of telomere to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q9D666-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TY60-1", "uniprot_id": [ { "id": "F131B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TY60", "type": "external" } ], "mass": 35958.0, "length": 332, "protein_name": "Protein FAM131B", "gene_name": "Fam131b", "organism": "Mouse", "refseq_name": "protein FAM131B isoform b", "refseq_ac": [ { "id": "NP_001106798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106798", "type": "external" } ], "gene_names_uniprotkb": "Fam131b", "gene_names_refseq": "6330503C03Rik; 6530406I18Rik; Fam131b", "protein_names_uniprotkb": "Protein FAM131B", "protein_names_refseq": "protein FAM131B isoform b; protein FAM131B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76156)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16452087;17114649;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQE4;Q9D390", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TY60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N480-1", "uniprot_id": [ { "id": "L7N480_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N480", "type": "external" } ], "mass": 83702.0, "length": 754, "protein_name": "Golgi associated RAB2 interactor family member 5B", "gene_name": "Garin5b", "organism": "Mouse", "refseq_name": "Golgi-associated RAB2 interactor protein 5B", "refseq_ac": [ { "id": "NP_766483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766483", "type": "external" } ], "gene_names_uniprotkb": "Garin5b", "gene_names_refseq": "4930401F20Rik; Fam71e2; Garin5b", "protein_names_uniprotkb": "Golgi associated RAB2 interactor family member 5B", "protein_names_refseq": "Golgi-associated RAB2 interactor protein 5B; family with sequence similarity 71, member E2", "tax_id": 10090, "disease": "", "pathway": " (mmu:243822)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "L7N480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z2W7-1", "uniprot_id": [ { "id": "D3Z2W7_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z2W7", "type": "external" } ], "mass": 58034.0, "length": 503, "protein_name": "Cytochrome P450 3A", "gene_name": "Cyp3a59", "organism": "Mouse", "refseq_name": "cytochrome P450, family 3, subfamily a, polypeptide 59", "refseq_ac": [ { "id": "NP_001098630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098630", "type": "external" } ], "gene_names_uniprotkb": "Cyp3a59", "gene_names_refseq": "Cyp3a59", "protein_names_uniprotkb": "Cytochrome P450 3A; 1.14.14.-", "protein_names_refseq": "cytochrome P450, family 3, subfamily a, polypeptide 59; cytochrome P450, subfamily 3A, polypeptide 59", "tax_id": 10090, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); oral submucous fibrosis (Disease Ontology:DOID:5773); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:100041449); (R-MMU-211945); (R-MMU-211958); (R-MMU-211981); (R-MMU-5423646); (R-MMU-9027307); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070989 oxidative demethylation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z2W7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27889-1", "uniprot_id": [ { "id": "HNF1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P27889", "type": "external" } ], "mass": 61588.0, "length": 558, "protein_name": "Hepatocyte nuclear factor 1-beta", "gene_name": "Hnf1b", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 1-beta isoform 2", "refseq_ac": [ { "id": "NP_001278197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278197", "type": "external" } ], "gene_names_uniprotkb": "Hnf1b; Hnf-1b; Tcf2", "gene_names_refseq": "HNF-1-beta; HNF-1Beta; HNF-1B; Hnf1beta; Hnf1b; LFB3; Tcf-2; Tcf2; vHNF1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; TCF-2; Transcription factor 2", "protein_names_refseq": "hepatocyte nuclear factor 1-beta isoform 2; hepatocyte nuclear factor 1-beta; homeoprotein LFB3; transcription factor 2", "tax_id": 10090, "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); renal cysts and diabetes syndrome (Disease Ontology:DOID:0111101); pancreas disease (Disease Ontology:DOID:26); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:21410)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10331425;11456274;1673925;17242355;21183079;21750661;30084848;31219806;39277686;40997131", "class_list": "", "function": "Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NC37;Q8R162;Q9CS26;Q9R1W1;Q9R1W2;Q9WTL5;Q9WTL6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0061017 hepatoblast differentiation;GO:0048806 genitalia development;GO:0060429 epithelium development;GO:0001714 endodermal cell fate specification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27889-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCW4-1", "uniprot_id": [ { "id": "ETFB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCW4", "type": "external" } ], "mass": 27623.0, "length": 255, "protein_name": "Electron transfer flavoprotein subunit beta", "gene_name": "Etfb", "organism": "Mouse", "refseq_name": "electron transfer flavoprotein subunit beta", "refseq_ac": [ { "id": "NP_080971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080971", "type": "external" } ], "gene_names_uniprotkb": "Etfb", "gene_names_refseq": "0610009I16Rik; 2810441H06Rik; Etfb", "protein_names_uniprotkb": "Electron transfer flavoprotein subunit beta; Beta-ETF", "protein_names_refseq": "beta-ETF; electron transfer flavoprotein subunit beta", "tax_id": 10090, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (mmu:110826); (R-MMU-611105); (R-MMU-8876725)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "21750661;23576753;23806337;25023281;25605945;26915330;31599954;31941714;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Hepatic neddylation also enhances ETFA and ETFB expression in adult mice and prevents fasting-induced steatosis and mortality., [RefSeq, PubMed]; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (By similarity). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:25023281). ETFB binds an AMP molecule that probably has a purely structural role (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results identify new protein-protein interactions between AIF-Cx43, ETFB-Cx43 and AIF-ETFB as possible players in the regulation of the mitochondrial redox state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810V3", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0017133 mitochondrial electron transfer flavoprotein complex;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045251 electron transfer flavoprotein complex", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904 respiratory electron transport chain;GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DCW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GRI2-1", "uniprot_id": [ { "id": "A0A1B0GRI2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GRI2", "type": "external" } ], "mass": 66113.0, "length": 571, "protein_name": "Predicted gene, 35315", "gene_name": "Gm35315", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm35315", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 35315", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GRI2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WQL6-1", "uniprot_id": [ { "id": "A0A087WQL6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WQL6", "type": "external" } ], "mass": 6212.0, "length": 57, "protein_name": "Keratin associated protein 20-1", "gene_name": "Krtap20-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 20-2", "refseq_ac": [ { "id": "NP_034804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034804", "type": "external" } ], "gene_names_uniprotkb": "Krtap20-1; Krtap6-3", "gene_names_refseq": "HGTpII.3; Krtap20-1; Krtap6-3", "protein_names_uniprotkb": "Keratin associated protein 20-1", "protein_names_refseq": "keratin associated protein 6-3; keratin-associated protein 20-2; keratin-associated protein 6.3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040249); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15385554;21750661", "class_list": "", "function": "Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A087WQL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UWW6-1", "uniprot_id": [ { "id": "G3UWW6_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UWW6", "type": "external" } ], "mass": 25715.0, "length": 228, "protein_name": "Cleavage and polyadenylation specificity factor subunit 4", "gene_name": "Cpsf4l", "organism": "Mouse", "refseq_name": "putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform 1", "refseq_ac": [ { "id": "NP_080958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080958", "type": "external" } ], "gene_names_uniprotkb": "Cpsf4l", "gene_names_refseq": "0610010C04Rik; 1500000C01Rik; Cpsf4l; D11Ertd636e", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 4; CPSF 30 kDa subunit; Cleavage and polyadenylation specificity factor 30 kDa subunit", "protein_names_refseq": "putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52670)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UWW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35215-1", "uniprot_id": [ { "id": "DOPD_MOUSE", "url": "https://www.uniprot.org/uniprot/O35215", "type": "external" } ], "mass": 13077.0, "length": 118, "protein_name": "D-dopachrome decarboxylase", "gene_name": "Ddt", "organism": "Mouse", "refseq_name": "D-dopachrome decarboxylase", "refseq_ac": [ { "id": "NP_034157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034157", "type": "external" } ], "gene_names_uniprotkb": "Ddt", "gene_names_refseq": "Ddt", "protein_names_uniprotkb": "D-dopachrome decarboxylase; 4.1.1.84; D-dopachrome tautomerase", "protein_names_refseq": "D-dopachrome decarboxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:13202)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23806337;30084848;34428180;35820727;37453647;37464010;9716662;9858785", "class_list": "", "function": "Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0005126 cytokine receptor binding;GO:0033981 D-dopachrome decarboxylase activity;GO:0050178 phenylpyruvate tautomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0050729 positive regulation of inflammatory response;GO:0042438 melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35215-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WT4-1", "uniprot_id": [ { "id": "DJC17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WT4", "type": "external" } ], "mass": 34465.0, "length": 303, "protein_name": "DnaJ homolog subfamily C member 17", "gene_name": "Dnajc17", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 17", "refseq_ac": [ { "id": "NP_631878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631878", "type": "external" } ], "gene_names_uniprotkb": "Dnajc17", "gene_names_refseq": "1700025B16Rik; D9Bwg1371e; Dnajc17", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 17", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 17; dnaJ homolog subfamily C member 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:69408)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20160132;25605945", "class_list": "", "function": "Dnajc17 is highly expressed in the thyroid bud and had an essential function in development, suggesting an important role of this protein in organogenesis and/or function of the thyroid gland., [RefSeq, PubMed]; May negatively affect PAX8-induced thyroglobulin/TG transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGH2;Q8C5R1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR25-1", "uniprot_id": [ { "id": "DPH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR25", "type": "external" } ], "mass": 52365.0, "length": 489, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "gene_name": "Dph2", "organism": "Mouse", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_080620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080620", "type": "external" } ], "gene_names_uniprotkb": "Dph2; Dph2l2", "gene_names_refseq": "9130020C19Rik; Dph2l2; Dph2", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; MmDph2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase DPH2", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform 1; 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; DPH2-like 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase DPH2; diphthamide biosynthesis protein 2 homolog-like 2; diphtheria toxin resistance protein 2; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 2", "tax_id": 10090, "disease": "diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 2 (Disease Ontology:DOID:0070478)", "pathway": " (mmu:67728); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15485916;17242355;21203470;21750661;34428180;37507081", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0L8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CR25-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZK7-1", "uniprot_id": [ { "id": "DOK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZK7", "type": "external" } ], "mass": 48027.0, "length": 444, "protein_name": "Docking protein 3", "gene_name": "Dok3", "organism": "Mouse", "refseq_name": "docking protein 3", "refseq_ac": [ { "id": "NP_038767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038767", "type": "external" } ], "gene_names_uniprotkb": "Dok3; Dokl", "gene_names_refseq": "Dok3; Dokl", "protein_names_uniprotkb": "Docking protein 3; DOK-L; Downstream of tyrosine kinase 3; p62(dok)-like protein", "protein_names_refseq": "DOK-L; Dok-like protein; docking protein 3; downstream of tyrosine kinase 3; p62(dok)-like protein; p62Dok-like protein", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:27261); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10567556;10733577;14993273;17947660;19144319;21183079;26495903;34245977;34743196;36970719;37906628", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function., [UniProtKB, PubMed]; DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11., [RefSeq, PubMed]; Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis., [RefSeq, PubMed]; Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QZK7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Y0-1", "uniprot_id": [ { "id": "DYRK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Y0", "type": "external" } ], "mass": 65572.0, "length": 586, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 3", "gene_name": "Dyrk3", "organism": "Mouse", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a", "refseq_ac": [ { "id": "NP_663483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663483", "type": "external" } ], "gene_names_uniprotkb": "Dyrk3", "gene_names_refseq": "Dyrk3", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 3; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:226419)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12356771;15607427;16524748;20167603;21750661;23415227;29237092;31219806;34171798;34428180", "class_list": "", "function": "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1., [RefSeq, PubMed]; DYRK3 contributes to differentiation and hypoxic control in neuroblastoma., [RefSeq, PubMed]; DYRK3, expression is strong in erythroid cells and testis, but is also detected in adult kidney and liver, [RefSeq, PubMed]; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:12356771). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (By similarity). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (By similarity). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (By similarity). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (By similarity). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (By similarity). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (By similarity). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603)., [UniProtKB, UniProtKB, PubMed, PubMed]; Study identified the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein with the ability to condense P-granule-like speckles in the cytosol and to prevent stress granule dissolution via its N-terminal domain when it is in a kinase-inactive form., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM34", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:1903008 organelle disassembly;GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q922Y0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCG4-1", "uniprot_id": [ { "id": "DPPA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCG4", "type": "external" } ], "mass": 32699.0, "length": 296, "protein_name": "Developmental pluripotency-associated protein 4", "gene_name": "Dppa4", "organism": "Mouse", "refseq_name": "developmental pluripotency-associated protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001018002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018002", "type": "external" } ], "gene_names_uniprotkb": "Dppa4", "gene_names_refseq": "2410091M23Rik; Dppa4; ECAT15-1", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 4; ECAT15-1; Embryonic stem cell-associated transcript 15-1 protein", "protein_names_refseq": "developmental pluripotency-associated protein 4 isoform 2; developmental pluripotency-associated protein 4; embryonic stem cell-associated transcript 15-1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73693)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12620990;16990585;17855347;18366076;21750661;21896782;34428180;34878123;34931676;36852467", "class_list": "", "function": "DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development., [RefSeq, PubMed]; DPPA4 is a nuclear factor associated with active chromatin, [RefSeq, PubMed]; Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival., [RefSeq, PubMed]; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage., [UniProtKB, PubMed, PubMed]; Study of expression and function of pluripotent markers such as Dppa2 and Dppa4 is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals., [RefSeq, PubMed]; Thsi study identifies DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P228;Q810Y6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048731 system development;GO:0006351 DNA-templated transcription;GO:0010467 gene expression;GO:0060484 lung-associated mesenchyme development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CCG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39054-1", "uniprot_id": [ { "id": "DYN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P39054", "type": "external" } ], "mass": 98145.0, "length": 870, "protein_name": "Dynamin-2", "gene_name": "Dnm2", "organism": "Mouse", "refseq_name": "dynamin-2 isoform 1", "refseq_ac": [ { "id": "NP_001240822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240822", "type": "external" } ], "gene_names_uniprotkb": "Dnm2; Dyn2", "gene_names_refseq": "Dnm2; Dyn2; Udnm; b2b2159Clo", "protein_names_uniprotkb": "Dynamin-2; 3.6.5.5; Dynamin UDNM", "protein_names_refseq": "dynamin-2 isoform 1", "tax_id": 10090, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); microcytic anemia (Disease Ontology:DOID:11252); centronuclear myopathy (Disease Ontology:DOID:14717); cystic kidney disease (Disease Ontology:DOID:2975); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (mmu:13430); (R-MMU-166016); (R-MMU-190873); (R-MMU-196025); (R-MMU-203641); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722); (R-MMU-437239); (R-MMU-8856828); (R-MMU-9766229)", "pathway_count": 11, "publication_count": 22, "publication_id_list": "15694365;16325581;17702744;18425118;18923138;21750661;21952136;22872234;23092955;23806337;26740625;31219806;33113375;33300544;34203471;34428180;35820727;36210013;37139790;37317811;39627609;9143510", "class_list": "", "function": "A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease., [RefSeq, PubMed]; BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes., [RefSeq, PubMed]; Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (By similarity). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:18923138). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (By similarity). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (PubMed:33113375). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (By similarity). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18, by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (By similarity). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (PubMed:18425118). Also plays a role in cytokinesis (PubMed:18923138). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBE1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0097749 membrane tubulation;GO:0061572 actin filament bundle organization;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P39054-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04117-1", "uniprot_id": [ { "id": "FABP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P04117", "type": "external" } ], "mass": 14650.0, "length": 132, "protein_name": "Fatty acid-binding protein, adipocyte", "gene_name": "Fabp4", "organism": "Mouse", "refseq_name": "fatty acid-binding protein, adipocyte isoform 1", "refseq_ac": [ { "id": "NP_077717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077717", "type": "external" } ], "gene_names_uniprotkb": "Fabp4; Ap2", "gene_names_refseq": "422/aP2; AFABP; ALBP/Ap2; ALBP; Ap2; Fabp4; Lbpl; P15", "protein_names_uniprotkb": "Fatty acid-binding protein, adipocyte; 3T3-L1 lipid-binding protein; A-FABP; AFABP; ALBP; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4; Myelin P2 protein homolog; P15; P2 adipocyte protein; Protein 422", "protein_names_refseq": "3T3-L1 lipid-binding protein; P2 adipocyte protein; adipocyte lipid-binding protein; adipocyte protein aP2; adipocyte-type fatty acid-binding protein; fatty acid-binding protein 4; fatty acid-binding protein, adipocyte isoform 1; fatty acid-binding protein, adipocyte; myelin P2 protein homolog; protein 422", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); impotence (Disease Ontology:DOID:1875); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:11770); (R-MMU-163560)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10423455;12077340;14594993;1554730;16574478;17516629;17761196;21183079;2452440;2844775;3015943;34428180;3520554;36288343;37507081;3968175;39927985;6206497;7929228;8161548;8447836;8463311", "class_list": "", "function": "Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0051427 hormone receptor binding;GO:0060229 lipase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0050872 white fat cell differentiation;GO:0050873 brown fat cell differentiation;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P04117-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVL6-1", "uniprot_id": [ { "id": "EXTL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVL6", "type": "external" } ], "mass": 104474.0, "length": 918, "protein_name": "Exostosin-like 3", "gene_name": "Extl3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Extl3", "gene_names_refseq": "", "protein_names_uniprotkb": "Exostosin-like 3; 2.4.1.223; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206)", "pathway": " (R-MMU-2022928)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19336225;21183079;25428506;28011936;28811323;35263589;36240758", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) (PubMed:19336225). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (By similarity). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (PubMed:19336225)., [UniProtKB, UniProtKB, PubMed]; Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway (PubMed:28811323, PubMed:35263589, PubMed:36240758). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (By similarity). Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway (By similarity). Required for the function of REG3A and REG3G in glucose tolerance in pancreas (PubMed:36240758). Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (PubMed:35263589)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QKN8", "ec_number_list": [ { "id": "2.4.1.223", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.223", "type": "external" } ], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0000287 magnesium ion binding;GO:0016757 glycosyltransferase activity;GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0030307 positive regulation of cell growth;GO:0032496 response to lipopolysaccharide;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9WVL6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YX91-1", "uniprot_id": [ { "id": "A0A0A6YX91_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YX91", "type": "external" } ], "mass": 13435.0, "length": 119, "protein_name": "Immunoglobulin heavy variable 7-2", "gene_name": "Ighv7-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv7-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 7-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A6YX91-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7M2-1", "uniprot_id": [ { "id": "T22D2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7M2", "type": "external" } ], "mass": 78197.0, "length": 769, "protein_name": "TSC22 domain family protein 2", "gene_name": "Tsc22d2", "organism": "Mouse", "refseq_name": "TSC22 domain family protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001074698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074698", "type": "external" } ], "gene_names_uniprotkb": "Tsc22d2", "gene_names_refseq": "1810043J12Rik; 5530402M19Rik; Tsc22d2", "protein_names_uniprotkb": "TSC22 domain family protein 2", "protein_names_refseq": "TSC22 domain family 2; TSC22 domain family protein 2 isoform 1; TSC22 domain family protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72033)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17147695;21750661;25153642;25428506;26495903;28011936;28528544;32152506", "class_list": "", "function": "All TSC22D2 transcripts depend on hypertonicity as the signal for their upregulation and are unresponsive to increases in cell-permeable osmolytes. mRNA stabilization is the mechanism for TSC22D2 upregulation by hyperosmolality., [RefSeq, PubMed]; May protect kidney cells from hyperosmotic stress., [UniProtKB, PubMed]; Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JFZ4;A7LCN1;Q3V1I7;Q6PE86", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006970 response to osmotic stress;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9Q7M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMQ6-1", "uniprot_id": [ { "id": "J3QMQ6_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMQ6", "type": "external" } ], "mass": 20695.0, "length": 198, "protein_name": "Predicted gene 3336", "gene_name": "Gm3336", "organism": "Mouse", "refseq_name": "uncharacterized LOC729966 homolog precursor", "refseq_ac": [ { "id": "NP_001182182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182182", "type": "external" } ], "gene_names_uniprotkb": "Gm3336", "gene_names_refseq": "100041434; 2410018E23Rik; Gm3336", "protein_names_uniprotkb": "Predicted gene 3336", "protein_names_refseq": "uncharacterized LOC729966 homolog precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100502950)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QMQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PWS6-1", "uniprot_id": [ { "id": "E9PWS6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWS6", "type": "external" } ], "mass": 11591.0, "length": 100, "protein_name": "RIKEN cDNA A630073D07 gene", "gene_name": "A630073D07Rik", "organism": "Mouse", "refseq_name": "Gliadoralin-A-like precursor", "refseq_ac": [ { "id": "NP_001136441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136441", "type": "external" } ], "gene_names_uniprotkb": "A630073D07Rik", "gene_names_refseq": "A630073D07Rik; Gm1688", "protein_names_uniprotkb": "RIKEN cDNA A630073D07 gene", "protein_names_refseq": "Gliadoralin-A-like precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:381819)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PWS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1C7-1", "uniprot_id": [ { "id": "E9Q1C7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1C7", "type": "external" } ], "mass": 29931.0, "length": 252, "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4A2", "gene_name": "Speer4a2", "organism": "Mouse", "refseq_name": "spermatogenesis associated glutamate (E)-rich protein 4-like", "refseq_ac": [ { "id": "NP_001171050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171050", "type": "external" } ], "gene_names_uniprotkb": "Speer4a2; Gm10471", "gene_names_refseq": "Gm10471; Speer4a2", "protein_names_uniprotkb": "Spermatogenesis associated glutamate (E)-rich protein 4A2", "protein_names_refseq": "spermatogenesis associated glutamate (E)-rich protein 4-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039045)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q1C7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q281-1", "uniprot_id": [ { "id": "E9Q281_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q281", "type": "external" } ], "mass": 97705.0, "length": 856, "protein_name": "Vomeronasal 2, receptor 114", "gene_name": "Vmn2r114", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r114 precursor", "refseq_ac": [ { "id": "NP_001096054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096054", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r114", "gene_names_refseq": "EG666002; V2Rp3; Vmn2r114", "protein_names_uniprotkb": "Vomeronasal 2, receptor 114", "protein_names_refseq": "vomeronasal 2 receptor p3; vomeronasal receptor Vmn2r114 precursor; vomeronasal receptor Vmn2r114", "tax_id": 10090, "disease": "", "pathway": " (mmu:666002)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q281-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMS9-1", "uniprot_id": [ { "id": "J3QMS9_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMS9", "type": "external" } ], "mass": 12236.0, "length": 113, "protein_name": "RIKEN cDNA E030018B13 gene", "gene_name": "E030018B13Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC381994", "refseq_ac": [ { "id": "NP_001243240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243240", "type": "external" } ], "gene_names_uniprotkb": "E030018B13Rik", "gene_names_refseq": "E030018B13Rik; Gm1697", "protein_names_uniprotkb": "RIKEN cDNA E030018B13 gene", "protein_names_refseq": "uncharacterized protein LOC381994", "tax_id": 10090, "disease": "", "pathway": " (mmu:381994)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QMS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6Z8-1", "uniprot_id": [ { "id": "K7N6Z8_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6Z8", "type": "external" } ], "mass": 97011.0, "length": 848, "protein_name": "Vomeronasal 2, receptor 9", "gene_name": "Vmn2r9", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001098091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098091", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r9", "gene_names_refseq": "EG435864; Vmn2r9", "protein_names_uniprotkb": "Vomeronasal 2, receptor 9", "protein_names_refseq": "vomeronasal 2, receptor 9 isoform 1 precursor; vomeronasal receptor Vmn2r9", "tax_id": 10090, "disease": "", "pathway": " (mmu:435864)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1K1-1", "uniprot_id": [ { "id": "A0A0B4J1K1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1K1", "type": "external" } ], "mass": 12160.0, "length": 110, "protein_name": "T cell receptor alpha variable 4-3", "gene_name": "Trav4-3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav4-3", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 4-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1K1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0N4SW31-1", "uniprot_id": [ { "id": "A0A0N4SW31_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0N4SW31", "type": "external" } ], "mass": 5381.0, "length": 51, "protein_name": "Matrix metallopeptidase 24 opposite strand transcript 1", "gene_name": "Mmp24os1", "organism": "Mouse", "refseq_name": "protein MMP24OS", "refseq_ac": [ { "id": "NP_001371098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001371098", "type": "external" } ], "gene_names_uniprotkb": "Mmp24os1; BC029722", "gene_names_refseq": "Mmp24os1", "protein_names_uniprotkb": "Matrix metallopeptidase 24 opposite strand transcript 1", "protein_names_refseq": "protein MMP24OS", "tax_id": 10090, "disease": "", "pathway": " (mmu:613262)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0N4SW31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3Z1-1", "uniprot_id": [ { "id": "E9Q3Z1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3Z1", "type": "external" } ], "mass": 14633.0, "length": 139, "protein_name": "RIKEN cDNA B230217C12 gene", "gene_name": "B230217C12Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "B230217C12Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RIKEN cDNA B230217C12 gene", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:68127)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q3Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W2P7V2-1", "uniprot_id": [ { "id": "A0A1W2P7V2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1W2P7V2", "type": "external" } ], "mass": 27189.0, "length": 236, "protein_name": "GLI pathogenesis-related 1 like 3", "gene_name": "Glipr1l3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Glipr1l3", "gene_names_refseq": "", "protein_names_uniprotkb": "GLI pathogenesis-related 1 like 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P7V2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6X8Z9-1", "uniprot_id": [ { "id": "TEX55_MOUSE", "url": "https://www.uniprot.org/uniprot/A6X8Z9", "type": "external" } ], "mass": 43579.0, "length": 381, "protein_name": "Testis-specific expressed protein 55", "gene_name": "Tex55", "organism": "Mouse", "refseq_name": "testis-specific expressed protein 55 isoform 1", "refseq_ac": [ { "id": "NP_083318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083318", "type": "external" } ], "gene_names_uniprotkb": "Tex55; Tscpa", "gene_names_refseq": "4930435E12Rik; TSCPA; Tex55", "protein_names_uniprotkb": "Testis-specific expressed protein 55; Testis-specific conserved, cAMP-dependent type II PK-anchoring protein", "protein_names_refseq": "testis-specific conserved, cAMP dependent type PK anchoring protein; testis-specific conserved, cAMP-dependent type II PK-anchoring protein; testis-specific expressed protein 55 isoform 1; testis-specific expressed protein 55; uncharacterized protein C3orf30 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74663)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19821082;33458765", "class_list": "", "function": "TSCPA was expressed specifically in mouse and human testis and might play an important role in spermatogenesis., [RefSeq, PubMed]; Tex55 encodes a conserved putative A-kinase anchoring protein dispensable for male fertility in the mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4QMY3;Q8C5T0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6X8Z9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AUC4-1", "uniprot_id": [ { "id": "B1AUC4_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AUC4", "type": "external" } ], "mass": 41847.0, "length": 352, "protein_name": "Ubiquitin-conjugating enzyme E2 U", "gene_name": "Ube2u", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 U", "refseq_ac": [ { "id": "NP_001028945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028945", "type": "external" } ], "gene_names_uniprotkb": "Ube2u", "gene_names_refseq": "Ube2u", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 U; E2 ubiquitin-conjugating enzyme U; Ubiquitin carrier protein U; Ubiquitin-protein ligase U", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 U", "tax_id": 10090, "disease": "", "pathway": " (mmu:381534)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0000209 protein polyubiquitination;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AUC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z298-1", "uniprot_id": [ { "id": "D3Z298_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z298", "type": "external" } ], "mass": 62087.0, "length": 562, "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces1h", "organism": "Mouse", "refseq_name": "carboxylesterase 1H precursor", "refseq_ac": [ { "id": "NP_001357759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357759", "type": "external" } ], "gene_names_uniprotkb": "Ces1h", "gene_names_refseq": "2310039D24Rik; Ces1h", "protein_names_uniprotkb": "Carboxylic ester hydrolase; 3.1.1.-", "protein_names_refseq": "carboxylesterase 1H precursor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:75704)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2E9-1", "uniprot_id": [ { "id": "E9Q2E9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2E9", "type": "external" } ], "mass": 19034.0, "length": 183, "protein_name": "Keratin-associated protein", "gene_name": "Krtap11-1", "organism": "Mouse", "refseq_name": "keratin associated protein 11-1", "refseq_ac": [ { "id": "NP_001106877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106877", "type": "external" } ], "gene_names_uniprotkb": "Krtap11-1", "gene_names_refseq": "Hacl1; KAP11.1; Krtap11-1; PRED29", "protein_names_uniprotkb": "Keratin-associated protein", "protein_names_refseq": "keratin associated protein 11-1; keratin-associated protein 11.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16693); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q2E9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6D3-1", "uniprot_id": [ { "id": "E9Q6D3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6D3", "type": "external" } ], "mass": 38346.0, "length": 323, "protein_name": "Coiled-coil domain containing 121, retrogene 1", "gene_name": "Ccdc121rt1", "organism": "Mouse", "refseq_name": "coiled-coil domain containing 121rt1", "refseq_ac": [ { "id": "NP_997163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997163", "type": "external" } ], "gene_names_uniprotkb": "Ccdc121rt1", "gene_names_refseq": "6530421E24Rik; Ccdc121rt1; Ccdc121; Gm755", "protein_names_uniprotkb": "Coiled-coil domain containing 121, retrogene 1", "protein_names_refseq": "coiled-coil domain containing 121rt1; coiled-coil domain containing 121", "tax_id": 10090, "disease": "", "pathway": " (mmu:403180)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q6D3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UYQ4-1", "uniprot_id": [ { "id": "KAD9_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UYQ4", "type": "external" } ], "mass": 219534.0, "length": 1894, "protein_name": "Adenylate kinase 9", "gene_name": "Ak9", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ak9", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate kinase 9; 2.7.4.4; 2.7.4.6", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 89 (Disease Ontology:DOID:0070588); normal pressure hydrocephalus (Disease Ontology:DOID:1572)", "pathway": " (R-MMU-499943)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37713809", "class_list": "", "function": "Broad-specificity nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. For this activity shows the following substrate preference CDP > UDP > ADP > TDP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" } ], "go_molecular_function": "GO:0050145 nucleoside monophosphate kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031514 motile cilium", "go_biological_process": "GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UYQ4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6V2-1", "uniprot_id": [ { "id": "K7N6V2_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6V2", "type": "external" } ], "mass": 98577.0, "length": 862, "protein_name": "Vomeronasal 2, receptor 58", "gene_name": "Vmn2r58", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r58 precursor", "refseq_ac": [ { "id": "NP_001098525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098525", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r58", "gene_names_refseq": "EG628422; Vmn2r58", "protein_names_uniprotkb": "Vomeronasal 2, receptor 58", "protein_names_refseq": "vomeronasal receptor Vmn2r58 precursor; vomeronasal receptor Vmn2r58", "tax_id": 10090, "disease": "", "pathway": " (mmu:628422)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6V2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N709-1", "uniprot_id": [ { "id": "K7N709_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N709", "type": "external" } ], "mass": 97542.0, "length": 852, "protein_name": "Vomeronasal 2, receptor 47", "gene_name": "Vmn2r47", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 47", "refseq_ac": [ { "id": "NP_001098621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098621", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r47", "gene_names_refseq": "Gm10302; Vmn2r47", "protein_names_uniprotkb": "Vomeronasal 2, receptor 47", "protein_names_refseq": "vomeronasal 2, receptor 47; vomeronasal receptor Vmn2r47", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042891)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N709-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0QWR8-1", "uniprot_id": [ { "id": "M0QWR8_MOUSE", "url": "https://www.uniprot.org/uniprot/M0QWR8", "type": "external" } ], "mass": 73819.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "Slco1a8", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slco1a8", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:625716)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0QWR8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1H7-1", "uniprot_id": [ { "id": "A0A0B4J1H7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1H7", "type": "external" } ], "mass": 13305.0, "length": 120, "protein_name": "Immunoglobulin kappa variable 1-135", "gene_name": "Igkv1-135", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv1-135", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa variable 1-135", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "21750661;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0B4J1H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GSG7-1", "uniprot_id": [ { "id": "A0A1B0GSG7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GSG7", "type": "external" } ], "mass": 109837.0, "length": 984, "protein_name": "Kinesin-like protein", "gene_name": "Kif19b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kif19b; Gm4869", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;30059200", "class_list": "", "function": "Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A1B0GSG7-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QK46-1", "uniprot_id": [ { "id": "J3QK46_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QK46", "type": "external" } ], "mass": 66184.0, "length": 637, "protein_name": "Transmembrane protein 200C", "gene_name": "Tmem200c", "organism": "Mouse", "refseq_name": "transmembrane protein 200C", "refseq_ac": [ { "id": "NP_001193590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193590", "type": "external" } ], "gene_names_uniprotkb": "Tmem200c", "gene_names_refseq": "EG622645; Gm6338; Tmem200c", "protein_names_uniprotkb": "Transmembrane protein 200C", "protein_names_refseq": "transmembrane protein 200C", "tax_id": 10090, "disease": "", "pathway": " (mmu:622645)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27802388", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "J3QK46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0QW81-1", "uniprot_id": [ { "id": "M0QW81_MOUSE", "url": "https://www.uniprot.org/uniprot/M0QW81", "type": "external" } ], "mass": 27188.0, "length": 227, "protein_name": "Predicted gene, 3488", "gene_name": "Gm3488", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041735 isoform 2", "refseq_ac": [ { "id": "NP_001243814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243814", "type": "external" } ], "gene_names_uniprotkb": "Gm3488", "gene_names_refseq": "100041735; 100041747; Gm3488; Gm3494", "protein_names_uniprotkb": "Predicted gene, 3488", "protein_names_refseq": "uncharacterized protein LOC100041735 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041735); (mmu:666329)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0QW81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28776-1", "uniprot_id": [ { "id": "I23O1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28776", "type": "external" } ], "mass": 45641.0, "length": 407, "protein_name": "Indoleamine 2,3-dioxygenase 1", "gene_name": "Ido1", "organism": "Mouse", "refseq_name": "indoleamine 2,3-dioxygenase 1 isoform 2", "refseq_ac": [ { "id": "NP_001280619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280619", "type": "external" } ], "gene_names_uniprotkb": "Ido1; Ido; Indo", "gene_names_refseq": "Ido1; Ido; Indo", "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 1; 1.13.11.52; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase", "protein_names_refseq": "IDO-1; indole 2,3-dioxygenase; indoleamine 2,3-dioxygenase 1 isoform 2; indoleamine-pyrrole 2,3 dioxygenase", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); chlamydia (Disease Ontology:DOID:11263); dengue disease (Disease Ontology:DOID:12205); toxic shock syndrome (Disease Ontology:DOID:14115); pulmonary tuberculosis (Disease Ontology:DOID:2957); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); eczema herpeticum (Disease Ontology:DOID:9123)", "pathway": " (mmu:15930); (R-MMU-71240)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15063630;18026683;18384884;1937018;19741271;21750661;22157149;25691885", "class_list": "", "function": "Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (PubMed:15063630)., [UniProtKB, PubMed, UniProtKB, PubMed]; Catalyzes the first and rate limiting step of the catabolism of tryptophan along the kynurenine pathway. Involved in immune regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030485 smooth muscle contractile fiber;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0002666 positive regulation of T cell tolerance induction;GO:0032693 negative regulation of interleukin-10 production;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0019441 L-tryptophan catabolic process to kynurenine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28776-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1P8-1", "uniprot_id": [ { "id": "I2BP2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1P8", "type": "external" } ], "mass": 59292.0, "length": 570, "protein_name": "Interferon regulatory factor 2-binding protein 2", "gene_name": "Irf2bp2", "organism": "Mouse", "refseq_name": "interferon regulatory factor 2-binding protein 2", "refseq_ac": [ { "id": "NP_001158070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158070", "type": "external" } ], "gene_names_uniprotkb": "Irf2bp2", "gene_names_refseq": "E130305N23Rik; IRF-2BP2; Irf2bp2", "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; IRF-2BP2", "protein_names_refseq": "IRF-2-binding protein 2; interferon regulatory factor 2-binding protein 2", "tax_id": 10090, "disease": "common variable immunodeficiency 14 (Disease Ontology:DOID:0081156); neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:270110)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;20485683;20702774;21183079;25428506;26195219;27286791;28135057;28716987;30016717;30084848;31219806;31529495;32239393;32782141;32848054;34428180;35865523;40885482", "class_list": "", "function": "Ablation of IRF2BP2 in macrophages worsens atherosclerosis in mice., [RefSeq, PubMed]; Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity)., [UniProtKB, UniProtKB]; Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease by Directly Repressing the Transcription of ATF3., [RefSeq, PubMed]; IRF2BP2 as a novel negative regulator in controlling pathological Cardiac Hypertrophy at the transcriptional level was defined., [RefSeq, PubMed]; IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles., [RefSeq, PubMed]; Interferon Regulatory Factor-2 Binding Protein 2 Ameliorates Sepsis-Induced Cardiomyopathy via AMPK-Mediated Anti-Inflammation and Anti-Apoptosis., [RefSeq, PubMed]; Irf2bp2 gene expression was decreased in CD4 T cells upon activation. Ectopic expression of IRF2BP2 led to a reduction in CD25 expression and STAT5 phosphorylation, along with an impaired proliferative capacity. IRF2BP2 overexpression in differentiated Th cells resulted in reduced IL-4 and pro-TGF-beta production in Th2 and iTregs but had no effect on IFN-gamma or IL-17 expression in Th1 and Th17 cells, respectively., [RefSeq, PubMed]; Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2-Null Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJC6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "E9Q1P8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4C2-3", "uniprot_id": [ { "id": "I17RC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4C2", "type": "external" } ], "mass": 77148.0, "length": 698, "protein_name": "Interleukin-17 receptor C", "gene_name": "Il17rc", "organism": "Mouse", "refseq_name": "interleukin-17 receptor C isoform 2", "refseq_ac": [ { "id": "NP_598920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598920", "type": "external" } ], "gene_names_uniprotkb": "Il17rc", "gene_names_refseq": "1110025H02Rik; Gm19850; IL-17RC; IL17-RC; IL17-RL; Il17rc; Il17rl", "protein_names_uniprotkb": "Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; IL-17RL; Interleukin-17 receptor-like protein; ZcytoR14", "protein_names_refseq": "IL-17 receptor C; IL-17RL; interleukin-17 receptor C isoform 2; interleukin-17 receptor-like protein; zcytoR14", "tax_id": 10090, "disease": "chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); interstitial lung disease (Disease Ontology:DOID:3082)", "pathway": " (mmu:171095)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16785495;17911633;19144317;20554964;26735852;27923703;28813677;30084848;32076265;34428180", "class_list": "", "function": "Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:19144317, PubMed:27923703). Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:20554964). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:27923703). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The biologic activity of IL-17 is dependent on a complex composed of receptors IL-17RA and IL-17RC., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3X9C0;Q99J43", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0032755 positive regulation of interleukin-6 production;GO:0071621 granulocyte chemotaxis;GO:0050832 defense response to fungus;GO:1900017 positive regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K4C2-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R409-1", "uniprot_id": [ { "id": "HEXI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R409", "type": "external" } ], "mass": 40243.0, "length": 356, "protein_name": "Protein HEXIM1", "gene_name": "Hexim1", "organism": "Mouse", "refseq_name": "protein HEXIM1", "refseq_ac": [ { "id": "NP_620092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620092", "type": "external" } ], "gene_names_uniprotkb": "Hexim1; Clp1", "gene_names_refseq": "7330426E13Rik; CLP-1; Clp1; HIS1; Hexim1", "protein_names_uniprotkb": "Protein HEXIM1; Cardiac lineage protein 1", "protein_names_refseq": "cardiac lineage protein 1; protein HEXIM1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192231)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12119119;15172687;17242355;18079413;20173027;21183079;22872234;25301555;25428506;26859361;28013147;28135057;28528544;28951318;30084848;30779550;34428180", "class_list": "", "function": "CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy, [RefSeq, PubMed]; Conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition, [RefSeq, PubMed]; Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively., [RefSeq, PubMed]; HEXIM1 plays critical roles in coronary vessel development and myocardial growth, [RefSeq, PubMed]; Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus., [RefSeq, PubMed]; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway., [UniProtKB, UniProtKB]; Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004860 protein kinase inhibitor activity;GO:0017069 snRNA binding;GO:0097322 7SK snRNA binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0120259 7SK snRNP", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8R409-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60598-1", "uniprot_id": [ { "id": "SRC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60598", "type": "external" } ], "mass": 61250.0, "length": 546, "protein_name": "Src substrate cortactin", "gene_name": "Cttn", "organism": "Mouse", "refseq_name": "src substrate cortactin isoform 1", "refseq_ac": [ { "id": "NP_031829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031829", "type": "external" } ], "gene_names_uniprotkb": "Cttn; Ems1", "gene_names_refseq": "1110020L01Rik; Cttn; Ems1", "protein_names_uniprotkb": "Src substrate cortactin", "protein_names_refseq": "mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin isoform 1; src substrate cortactin", "tax_id": 10090, "disease": "", "pathway": " (mmu:13043)", "pathway_count": 1, "publication_count": 52, "publication_id_list": "10.3389/fragi.2021.757801;11433297;12913069;17242355;17403031;17451412;17959782;18515860;20539040;21183079;21540332;22252131;22262902;22297987;22645316;23015759;23296090;23806337;24129315;24574519;24700464;24788674;25153642;25428506;25428507;25518936;26495903;28011936;28135057;28528544;30084848;30568170;30570111;31024527;31167468;31599954;31600191;32782141;32848054;33649389;34428180;34887587;35820727;35822049;36852467;37212571;37828378;38126170;40684658;40885482;7516062;7693700", "class_list": "", "function": "Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; ERbeta promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway., [RefSeq, PubMed]; Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGC2", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0070064 proline-rich region binding;GO:0005522 profilin binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0006886 intracellular protein transport;GO:0016477 cell migration;GO:0045987 positive regulation of smooth muscle contraction;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "Q60598-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U4G3-1", "uniprot_id": [ { "id": "XXLT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U4G3", "type": "external" } ], "mass": 43839.0, "length": 392, "protein_name": "Xyloside xylosyltransferase 1", "gene_name": "Xxylt1", "organism": "Mouse", "refseq_name": "xyloside xylosyltransferase 1", "refseq_ac": [ { "id": "NP_941028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941028", "type": "external" } ], "gene_names_uniprotkb": "Xxylt1", "gene_names_refseq": "Xxylt1", "protein_names_uniprotkb": "Xyloside xylosyltransferase 1; 2.4.2.62; UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase", "protein_names_refseq": "UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase; xyloside xylosyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268880)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26414444;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QL73;Q3TLX5;Q8K2I0", "ec_number_list": [ { "id": "2.4.2.62", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.62", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0035252 UDP-xylosyltransferase activity;GO:0140560 xylosyl alpha-1,3-xylosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 4, "hit_score": 0.3, "record_id": "Q3U4G3-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5RM54-1", "uniprot_id": [ { "id": "A0A1D5RM54_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1D5RM54", "type": "external" } ], "mass": 101878.0, "length": 893, "protein_name": "Maestro heat-like repeat family member 3", "gene_name": "Mroh3", "organism": "Mouse", "refseq_name": "maestro heat-like repeat family member 3", "refseq_ac": [ { "id": "NP_001316539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316539", "type": "external" } ], "gene_names_uniprotkb": "Mroh3", "gene_names_refseq": "2310006M14Rik; Mroh3", "protein_names_uniprotkb": "Maestro heat-like repeat family member 3", "protein_names_refseq": "maestro heat-like repeat family member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76422)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5RM54-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1P1-1", "uniprot_id": [ { "id": "A0A0B4J1P1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1P1", "type": "external" } ], "mass": 12602.0, "length": 111, "protein_name": "T cell receptor beta, variable 30", "gene_name": "Trbv30", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trbv30", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor beta, variable 30", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1P1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JEB6-1", "uniprot_id": [ { "id": "CFA47_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JEB6", "type": "external" } ], "mass": 360346.0, "length": 3184, "protein_name": "Cilia and flagella-associated protein 47", "gene_name": "Cfap47", "organism": "Mouse", "refseq_name": "cilia and flagella-associated protein 47", "refseq_ac": [ { "id": "NP_001355647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355647", "type": "external" } ], "gene_names_uniprotkb": "Cfap47", "gene_names_refseq": "100041373; Cfap47; Chdc2; Gm16462; Gm3297; Gm7173; Gm8787", "protein_names_uniprotkb": "Cilia and flagella-associated protein 47", "protein_names_refseq": "calponin homology domain containing 2; cilia and flagella-associated protein 47", "tax_id": 10090, "disease": "X-linked spermatogenic failure 3 (Disease Ontology:DOID:0112274); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:636104)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;33472045", "class_list": "", "function": "Plays a role in flagellar formation and sperm motility., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0120212 sperm head-tail coupling apparatus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060271 cilium assembly;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JEB6-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22907-1", "uniprot_id": [ { "id": "HEM3_MOUSE", "url": "https://www.uniprot.org/uniprot/P22907", "type": "external" } ], "mass": 39344.0, "length": 361, "protein_name": "Porphobilinogen deaminase", "gene_name": "Hmbs", "organism": "Mouse", "refseq_name": "porphobilinogen deaminase isoform 1", "refseq_ac": [ { "id": "NP_038579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038579", "type": "external" } ], "gene_names_uniprotkb": "Hmbs; Uros1", "gene_names_refseq": "Hmbs; PBGD; Ups; Uros1", "protein_names_uniprotkb": "Porphobilinogen deaminase; 2.5.1.61; HMBS; Hydroxymethylbilane synthase; PBG-D; Pre-uroporphyrinogen synthase", "protein_names_refseq": "PBG-D; porphobilinogen deaminase isoform 1; porphobilinogen deaminase; pre-uroporphyrinogen synthase", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); seminoma (Disease Ontology:DOID:4440); liver carcinoma (Disease Ontology:DOID:686)", "pathway": " (mmu:15288); (R-MMU-189451)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;23806337;2768242;30615115;32197664;32916704;34428180;8563760", "class_list": "glycogene", "function": "As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact., [UniProtKB, UniProtKB]; Brain ventricular enlargement in human and murine acute intermittent porphyria., [RefSeq, PubMed]; Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria. Publication Status: Online-Only, [RefSeq, PubMed]; To investigate the dramatically different manifestations, knock-in mice with human homozygous dominant-Acute intermittent porphyria (HD-AIP) missense mutations c.500G>A (p.Arg167Glu) or c.518_519GC>AG (p.Arg173Glu), designated R167Q or R173Q mice, respectively, were generated and compared with the previously established T1/T2 mice with ~30% residual HMBS activity and the heterozygous AIP phenotype, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIV0", "ec_number_list": [ { "id": "2.5.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.61", "type": "external" } ], "go_molecular_function": "GO:0004418 hydroxymethylbilane synthase activity;GO:0031406 carboxylic acid binding;GO:0004852 uroporphyrinogen-III synthase activity;GO:0043176 amine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0001889 liver development;GO:0006779 porphyrin-containing compound biosynthetic process;GO:0009410 response to xenobiotic stimulus;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P22907-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9Q5-1", "uniprot_id": [ { "id": "E9Q9Q5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9Q5", "type": "external" } ], "mass": 35550.0, "length": 327, "protein_name": "RIKEN cDNA 1700113H08 gene", "gene_name": "1700113H08Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C12orf42 homolog", "refseq_ac": [ { "id": "NP_083961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083961", "type": "external" } ], "gene_names_uniprotkb": "1700113H08Rik", "gene_names_refseq": "1700113H08Rik", "protein_names_uniprotkb": "RIKEN cDNA 1700113H08 gene", "protein_names_refseq": "uncharacterized protein C12orf42 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76640)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9Q5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LIP3-1", "uniprot_id": [ { "id": "A0A140LIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LIP3", "type": "external" } ], "mass": 30404.0, "length": 267, "protein_name": "RIKEN cDNA 4933424G06 gene", "gene_name": "4933424G06Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf92 homolog", "refseq_ac": [ { "id": "NP_001361251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361251", "type": "external" } ], "gene_names_uniprotkb": "4933424G06Rik", "gene_names_refseq": "1700104I15Rik; 4933424G06Rik", "protein_names_uniprotkb": "RIKEN cDNA 4933424G06 gene", "protein_names_refseq": "uncharacterized protein C2orf92 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71166)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LIP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH64-1", "uniprot_id": [ { "id": "EHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH64", "type": "external" } ], "mass": 61174.0, "length": 543, "protein_name": "EH domain-containing protein 2", "gene_name": "Ehd2", "organism": "Mouse", "refseq_name": "EH domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_694708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694708", "type": "external" } ], "gene_names_uniprotkb": "Ehd2", "gene_names_refseq": "C130052H20Rik; Ehd2", "protein_names_uniprotkb": "EH domain-containing protein 2", "protein_names_refseq": "EH domain-containing protein 2 isoform 1; EH domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:259300); (R-MMU-983231)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14676205;15345747;17914359;18502764;19131326;21177873;21183079;21750661;24508342;30084848;31219806;34203471;34428180;36625722;37507081;37703099", "class_list": "", "function": "ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:24508342). Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4 (PubMed:14676205). Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (PubMed:18502764, PubMed:21177873). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Appears to connect endocytosis to the actin cytoskeleton through interactions of its N-terminal domain with membranes and its C-terminal EH domain with the novel EHBP1 protein, [RefSeq, PubMed]; EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry. Publication Status: Online-Only, [RefSeq, PubMed]; EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL28", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0072659 protein localization to plasma membrane;GO:0060271 cilium assembly;GO:0030866 cortical actin cytoskeleton organization;GO:2001137 positive regulation of endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BH64-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1N2-1", "uniprot_id": [ { "id": "HDBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1N2", "type": "external" } ], "mass": 24566.0, "length": 228, "protein_name": "Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1", "gene_name": "Gpihbp1", "organism": "Mouse", "refseq_name": "glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_081006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081006", "type": "external" } ], "gene_names_uniprotkb": "Gpihbp1; Hbp1", "gene_names_refseq": "1110002J19Rik; GPI-HBP1; Gpihbp1", "protein_names_uniprotkb": "Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; GPI-HBP1; GPI-anchored HDL-binding protein 1; High density lipoprotein-binding protein 1", "protein_names_refseq": "glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor; glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1", "tax_id": 10090, "disease": "familial GPIHBP1 deficiency (Disease Ontology:DOID:0111420)", "pathway": " (mmu:68453); (R-MMU-163125); (R-MMU-8963889); (R-MMU-8963901); (R-MMU-975634)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "12496272;17403372;17620854;18340083;18713736;18787041;19304573;20620994;21750661;21844202;24726386;25387803;27811232;34428180;37172802;37974401", "class_list": "", "function": "AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats., [RefSeq, PubMed]; Eliminating the N-glycosylation site in a truncated soluble version of GPIHBP1 causes a modest reduction in the secretion of the protein. These studies demonstrate that N-glycosylation of GPIHBP1 is important for the trafficking of GPIHBP1 to cell surface, [RefSeq, PubMed]; GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries., [RefSeq, PubMed]; Gpihbp1 transcript levels in brown and white adipose tissue were lower in endothelial cell PPARgamma knockout mice than in littermate control mice, suggesting that PPARgamma regulates Gpihbp1 expression in vivo. (GPIHBP1) Erratum:[Mol Endocrinol. 2008 Dec;22(12):2766], [RefSeq, PubMed]; Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (PubMed:20620994). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (PubMed:20620994, PubMed:24726386, PubMed:27811232). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:17403372). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:18340083). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (PubMed:12496272)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress., [RefSeq, PubMed]; The acidic domain of GPIHBP1 is important and electrostatic interactions play a key role in ligand binding, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0008035 high-density lipoprotein particle binding;GO:0035473 lipase binding;GO:0060230 lipoprotein lipase activator activity;GO:0071813 lipoprotein particle binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006886 intracellular protein transport;GO:0042632 cholesterol homeostasis;GO:0050821 protein stabilization;GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D1N2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKE1-1", "uniprot_id": [ { "id": "H2A1B_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKE1", "type": "external" } ], "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-B", "gene_name": "H2ac4", "organism": "Mouse", "refseq_name": "histone H2A type 1-B", "refseq_ac": [ { "id": "NP_783591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783591", "type": "external" } ], "gene_names_uniprotkb": "H2ac4; Hist1h2ab", "gene_names_refseq": "H2A.1; H2a-53; H2ac4; Hist1h2ab", "protein_names_uniprotkb": "Histone H2A type 1-B", "protein_names_refseq": "histone 1, H2ab; histone H2A type 1-B; histone H2A type 1; histone cluster 1, H2ab", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 14, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;2249786;24352239;24681537;27105115;30154464;34428180;35984892;36511295;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "C0HKE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKE3-1", "uniprot_id": [ { "id": "H2A1D_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKE3", "type": "external" } ], "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-D", "gene_name": "H2ac7", "organism": "Mouse", "refseq_name": "histone H2A type 1-D", "refseq_ac": [ { "id": "NP_835495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835495", "type": "external" } ], "gene_names_uniprotkb": "H2ac7; Hist1h2ad", "gene_names_refseq": "H2ac7; Hist1h2ad", "protein_names_uniprotkb": "Histone H2A type 1-D", "protein_names_refseq": "histone 1, H2ad; histone H2A type 1-D; histone H2A type 1; histone cluster 1, H2ad", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 13, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;35820727;37828378;7217105;8858344", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "C0HKE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THW5-1", "uniprot_id": [ { "id": "H2AV_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THW5", "type": "external" } ], "mass": 13509.0, "length": 128, "protein_name": "Histone H2A.V", "gene_name": "H2az2", "organism": "Mouse", "refseq_name": "histone H2A.V isoform 1", "refseq_ac": [ { "id": "NP_084214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084214", "type": "external" } ], "gene_names_uniprotkb": "H2az2; H2afv; H2av", "gene_names_refseq": "C530002L11Rik; H2A.Z2; H2a.z-2; H2afv; H2av; H2az2; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre", "protein_names_uniprotkb": "Histone H2A.V; H2A.F/Z; H2A.Z variant histone 2", "protein_names_refseq": "H2A histone family, member V; H2A.Z variant histone 2; histone H2A.F/Z; histone H2A.V isoform 1; histone H2A.V", "tax_id": 10090, "disease": "", "pathway": " (mmu:77605); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 14, "publication_count": 3, "publication_id_list": "16204459;33725478;39627609", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NC92;Q6ZWU0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3THW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88705-1", "uniprot_id": [ { "id": "HCN3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88705", "type": "external" } ], "mass": 86641.0, "length": 779, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "gene_name": "Hcn3", "organism": "Mouse", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1", "refseq_ac": [ { "id": "NP_032253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032253", "type": "external" } ], "gene_names_uniprotkb": "Hcn3; Hac3", "gene_names_refseq": "BCNG-4; Bcng4; HAC-3; Hac3; Hcn3; Hcn4", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3; HAC-3; Hyperpolarization-activated cation channel 3", "protein_names_refseq": "hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:15168); (R-MMU-1296061)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12928435;15923185;17114649;21183079;21753018;21903939;23382386;31290157;37733590;9630217;9634236", "class_list": "", "function": "Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:15923185). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:21753018, PubMed:21903939, PubMed:31290157). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei (PubMed:31290157). Exerts a significant influence on the configuration of the cardiac action potential waveform (PubMed:21903939). Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (PubMed:31290157)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The distinct expression pattern in conjunction with the unusual biophysical properties implies that HCN3 may play an unique role in the body, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0035725 sodium ion transmembrane transport;GO:0003254 regulation of membrane depolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O88705-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70696-1", "uniprot_id": [ { "id": "H2B1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P70696", "type": "external" } ], "mass": 14237.0, "length": 127, "protein_name": "Histone H2B type 1-A", "gene_name": "H2bc1", "organism": "Mouse", "refseq_name": "histone H2B type 1-A", "refseq_ac": [ { "id": "NP_783594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783594", "type": "external" } ], "gene_names_uniprotkb": "H2bc1; Hist1h2ba; Th2b", "gene_names_refseq": "H2bc1; Hist1h2ba; Th2b", "protein_names_uniprotkb": "Histone H2B type 1-A; Histone H2B, testis; Testis-specific histone H2B", "protein_names_refseq": "histone 1, H2ba; histone H2B type 1-A; histone H2B, testis; histone cluster 1, H2ba; testis-specific histone H2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:319177); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 14, "publication_id_list": "12408966;21925322;22872234;23884607;24692660;26740625;26854224;28366643;29187734;30154464;30939211;31235600;31645732;8672246", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response., [RefSeq, PubMed]; TH2B and ZBTB16 co-localize in the neonatal testis. Upon the appearance of the primary spermatocytes, TH2B no longer co-localized with the ZBTB16 positive spermatogonia but were instead detected within the differentiating spermatogonia., [RefSeq, PubMed]; These data suggest that Rnf20 functions at the Rfx3 locus regulating cilia motility and cardiac situs and identify H2Bub1 as an upstream transcriptional regulator controlling tissue-specific expression of cilia genes. Our findings mechanistically link the two functional gene ontologies that have been implicated in human CHD: chromatin remodeling and cilia function., [RefSeq, PubMed]; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCL9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0042393 histone binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0000786 nucleosome", "go_biological_process": "GO:0006954 inflammatory response;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0031639 plasminogen activation;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70696-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00PI9-1", "uniprot_id": [ { "id": "HNRL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00PI9", "type": "external" } ], "mass": 84940.0, "length": 745, "protein_name": "Heterogeneous nuclear ribonucleoprotein U-like protein 2", "gene_name": "Hnrnpul2", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein U-like protein 2", "refseq_ac": [ { "id": "NP_001074665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074665", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpul2; Hnrpul2; Manp", "gene_names_refseq": "1110031M08Rik; Hnrnpul2; Hnrpul2", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U-like protein 2; MLF1-associated nuclear protein", "protein_names_refseq": "MLF1-associated nuclear protein; heterogeneous nuclear ribonucleoprotein U-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68693)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "17008314;17242355;18630941;19144319;20485683;21183079;24129315;25428506;28528544;29187734;34428180;34887587;35984892;37453647;39627609;40684658", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VPM4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse", "go_biological_process": "GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q00PI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWY9-1", "uniprot_id": [ { "id": "H2B1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWY9", "type": "external" } ], "mass": 13906.0, "length": 126, "protein_name": "Histone H2B type 1-C/E/G", "gene_name": "H2bc4; H2bc6; H2bc8", "organism": "Mouse", "refseq_name": "histone H2B type 1-C/E/G", "refseq_ac": [ { "id": "NP_001171124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171124", "type": "external" } ], "gene_names_uniprotkb": "H2bc4; H2bc6; H2bc8; Hist1h2bc; Hist1h2be; Hist1h2bg", "gene_names_refseq": "Gm11398; H2bc4; H2bc6; H2bc8; Hist1h2be", "protein_names_uniprotkb": "Histone H2B type 1-C/E/G", "protein_names_refseq": "histone 1, H2be; histone H2B type 1-C/E/G; histone cluster 1, H2be", "tax_id": 10090, "disease": "", "pathway": " (mmu:319179); (mmu:319181); (mmu:68024); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 23, "publication_count": 19, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;27105115;29187734;30154464;31645732;32822587;33300544;33649389;33725478;34428180;35984892;37453647;8676066", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates multiple transcripts through alternative splicing, the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6ZWY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLR9-1", "uniprot_id": [ { "id": "HIF1N_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLR9", "type": "external" } ], "mass": 40241.0, "length": 349, "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "Hif1an", "organism": "Mouse", "refseq_name": "hypoxia-inducible factor 1-alpha inhibitor", "refseq_ac": [ { "id": "NP_795932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795932", "type": "external" } ], "gene_names_uniprotkb": "Hif1an", "gene_names_refseq": "2310046M24Rik; A830014H24Rik; FIH1; FIH; Hif1an", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha inhibitor; 1.14.11.30; 1.14.11.n4; Hypoxia-inducible factor asparagine hydroxylase", "protein_names_refseq": "hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:319594); (R-MMU-1234174)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17636018;19892989;20173027;20399150;20720525;21808058;22095574;25428506;25605945;25671767;30084848;31219806;34428180;38422022", "class_list": "", "function": "Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment., [RefSeq, PubMed]; FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms., [RefSeq, PubMed]; Hydroxylates HIF-1 alpha at 'Asn-799' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation (By similarity). Positively regulates ASB4 activity, promoting vascular differentiation., [UniProtKB, UniProtKB, PubMed]; Lackin of hypoxia-inducible factor 1 alpha subunit inhibitor exhibit reduced body weight, elevated metabolic rate, hyperventilation, and improved glucose and lipid homeostasis and are resistant to high-fat-diet-induced weight gain and hepatic steatosis., [RefSeq, PubMed]; Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C in osteosarcoma., [RefSeq, PubMed]; Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3B7;Q3U3G4", "ec_number_list": [ { "id": "1.14.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.30", "type": "external" }, { "id": "1.14.11.n4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.n4", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0005112 Notch binding;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045746 negative regulation of Notch signaling pathway;GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BLR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7BAB2-1", "uniprot_id": [ { "id": "F7BAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/F7BAB2", "type": "external" } ], "mass": 119327.0, "length": 1078, "protein_name": "Transmembrane protein 132B", "gene_name": "Tmem132b", "organism": "Mouse", "refseq_name": "transmembrane protein 132B precursor", "refseq_ac": [ { "id": "NP_001177281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177281", "type": "external" } ], "gene_names_uniprotkb": "Tmem132b", "gene_names_refseq": "Tmem132b; mKIAA1786", "protein_names_uniprotkb": "Transmembrane protein 132B", "protein_names_refseq": "transmembrane protein 132B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:208151)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F7BAB2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K339-1", "uniprot_id": [ { "id": "KIN17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K339", "type": "external" } ], "mass": 44722.0, "length": 391, "protein_name": "DNA/RNA-binding protein KIN17", "gene_name": "Kin", "organism": "Mouse", "refseq_name": "DNA/RNA-binding protein KIN17 isoform 1", "refseq_ac": [ { "id": "NP_079556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079556", "type": "external" } ], "gene_names_uniprotkb": "Kin; Btcd; Kin17", "gene_names_refseq": "Kin17; Kin", "protein_names_uniprotkb": "DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN, antigenic determinant of recA protein", "protein_names_refseq": "DNA/RNA-binding protein KIN17 isoform 1; DNA/RNA-binding protein KIN17; KIN, antigenic determinant of recA protein homolog; antigenic determinant of rec-A protein; binding to curved DNA", "tax_id": 10090, "disease": "", "pathway": " (mmu:16588); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15252136;1715759;1923796;27853268;34428180;8670903;8954809", "class_list": "", "function": "Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This report demonstrates the importance of Kin17 as a critical factor that acts prior to the repair phase of DSB repair and is of bona fide importance for CSR. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV58", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006397 mRNA processing;GO:0006260 DNA replication;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K339-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97484-1", "uniprot_id": [ { "id": "LIRB3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97484", "type": "external" } ], "mass": 93054.0, "length": 841, "protein_name": "Paired immunoglobulin-like receptor B", "gene_name": "Pirb", "organism": "Mouse", "refseq_name": "paired immunoglobulin-like receptor B isoform 1 precursor", "refseq_ac": [ { "id": "NP_035225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035225", "type": "external" } ], "gene_names_uniprotkb": "Pirb; Lilrb3", "gene_names_refseq": "Gp91; LIR-3; Lilrb3; PIR-B; Pirb", "protein_names_uniprotkb": "Paired immunoglobulin-like receptor B; Cell-surface glycoprotein p91; LIR-3; Leukocyte immunoglobulin-like receptor 3; Leukocyte immunoglobulin-like receptor subfamily B member 3; PIR-B", "protein_names_refseq": "cell-surface glycoprotein p91; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; paired immunoglobulin-like receptor B isoform 1 precursor; paired immunoglobulin-like receptor B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18733)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10327049;10611342;11207596;19144319;35820727;38383888;39095838;39320067;9054430;9482905", "class_list": "", "function": "CaSSiDI: novel single-cell 'Cluster Similarity Scoring and Distinction Index' reveals critical functions for PirB and context-dependent Cebpb repression., [RefSeq, PubMed]; Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; May act as receptor for class I MHC antigens. Becomes activated upon coligation of PIRB and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)., [UniProtKB, PubMed, PubMed, PubMed]; Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030109 HLA-B specific inhibitory MHC class I receptor activity;GO:0032394 MHC class Ib receptor activity;GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007611 learning or memory;GO:1900271 regulation of long-term synaptic potentiation;GO:0001782 B cell homeostasis;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97484-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45KJ6-1", "uniprot_id": [ { "id": "LN28B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q45KJ6", "type": "external" } ], "mass": 26903.0, "length": 247, "protein_name": "Protein lin-28 homolog B", "gene_name": "Lin28b", "organism": "Mouse", "refseq_name": "protein lin-28 homolog B", "refseq_ac": [ { "id": "NP_001026942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026942", "type": "external" } ], "gene_names_uniprotkb": "Lin28b", "gene_names_refseq": "2810403D23Rik; D030047M17Rik; Lin-28.2; Lin28b", "protein_names_uniprotkb": "Protein lin-28 homolog B; Lin-28B", "protein_names_refseq": "lin-28B; protein lin-28 homolog B", "tax_id": 10090, "disease": "neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:380669)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19211792;21962509;22345399;22723554;22976955", "class_list": "", "function": "Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma., [RefSeq, PubMed]; Rpl22 inactivation promotes neoplastic transformation by inducing expression of Lin28B, [RefSeq, PubMed]; Study reports Lin28b is expressed in fetal liver and thymus, but not adult bone marrow or thymus; ectopic expression of Lin28 reprograms hematopoietic progenitor cells from adult bone marrow, endowing them with ability to mediate fetal-like lymphopoiesis, [RefSeq, PubMed]; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation. This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent. Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop (By similarity). Mediates MYC-induced let-7 repression (PubMed:19211792). When overexpressed, may stimulate growth of carcinoma cell lines (By similarity)., [UniProtKB, PubMed, UniProtKB]; When overexpressed in mice, both Lin28a and LIN28B promotes resistance to high-fat-diet induced diabetes; conversely, muscle-specific loss of Lin28a or overexpression of let-7 results in insulin resistance and impaired glucose tolerance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZC6;Q3V444", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050779 RNA destabilization;GO:2000635 negative regulation of primary miRNA processing;GO:0031054 pre-miRNA processing;GO:2000627 positive regulation of miRNA catabolic process;GO:2000632 negative regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q45KJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D945-1", "uniprot_id": [ { "id": "LLPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D945", "type": "external" } ], "mass": 15391.0, "length": 130, "protein_name": "Protein LLP homolog", "gene_name": "Llph", "organism": "Mouse", "refseq_name": "protein LLP homolog", "refseq_ac": [ { "id": "NP_079707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079707", "type": "external" } ], "gene_names_uniprotkb": "Llph", "gene_names_refseq": "1190005P17Rik; Llph", "protein_names_uniprotkb": "Protein LLP homolog; Protein LAPS18-like", "protein_names_refseq": "protein LLP homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26961175;34428180", "class_list": "", "function": "In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission., [UniProtKB, PubMed]; The characteristics and roles of previously unknown cell-permeable protein mLLP in modulating neural development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQP9", "ec_number_list": [], "go_molecular_function": "GO:0001099 basal RNA polymerase II transcription machinery binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0060999 positive regulation of dendritic spine development;GO:0097484 dendrite extension", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D945-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YY23-1", "uniprot_id": [ { "id": "LONF1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YY23", "type": "external" } ], "mass": 85106.0, "length": 762, "protein_name": "LON peptidase N-terminal domain and RING finger protein 1", "gene_name": "Lonrf1", "organism": "Mouse", "refseq_name": "LON peptidase N-terminal domain and RING finger protein 1", "refseq_ac": [ { "id": "NP_001074619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074619", "type": "external" } ], "gene_names_uniprotkb": "Lonrf1", "gene_names_refseq": "Lonrf1", "protein_names_uniprotkb": "LON peptidase N-terminal domain and RING finger protein 1", "protein_names_refseq": "LON peptidase N-terminal domain and RING finger protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244421); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;36888978", "class_list": "", "function": "Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YY23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1T1-1", "uniprot_id": [ { "id": "LRC25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1T1", "type": "external" } ], "mass": 32673.0, "length": 297, "protein_name": "Leucine-rich repeat-containing protein 25", "gene_name": "Lrrc25", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 25 precursor", "refseq_ac": [ { "id": "NP_694714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694714", "type": "external" } ], "gene_names_uniprotkb": "Lrrc25; Mapa", "gene_names_refseq": "Lrrc25; Mapa", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 25; Monocyte and plasmacytoid-activated protein", "protein_names_refseq": "leucine-rich repeat-containing protein 25 precursor; leucine-rich repeat-containing protein 25; monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:211228)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12384430;17947660;19144319;21183079;21750661;30340835", "class_list": "", "function": "LRRC25 as a critical molecular switch whose down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and NF-kappaB-dependent manner., [RefSeq, PubMed]; Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0006954 inflammatory response;GO:0007507 heart development;GO:0007249 canonical NF-kappaB signal transduction;GO:0051599 response to hydrostatic pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1T1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJV6-1", "uniprot_id": [ { "id": "LMTK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XJV6", "type": "external" } ], "mass": 150891.0, "length": 1424, "protein_name": "Serine/threonine-protein kinase LMTK3", "gene_name": "Lmtk3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase LMTK3 precursor", "refseq_ac": [ { "id": "NP_001005511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005511", "type": "external" } ], "gene_names_uniprotkb": "Lmtk3; Aatyk3", "gene_names_refseq": "Lmtk3; aatyk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase LMTK3; 2.7.11.1; Apoptosis-associated tyrosine kinase 3; Lemur tyrosine kinase 3", "protein_names_refseq": "apoptosis-associated tyrosine kinase 3; serine/threonine-protein kinase LMTK3 precursor; serine/threonine-protein kinase LMTK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381983)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16452087;17114649;17651901;20485683;21183079;21750661;22645316;24129315;24760852;25428506;31310731;40885482", "class_list": "", "function": "Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction. Further investigation revealed abnormalities in GluA1 trafficking after AMPA stimulation in Lmtk3-KO neurons, along with a reduction in GluA1 expression in the post-synaptic density., [RefSeq, PubMed]; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852)., [UniProtKB, UniProtKB, PubMed]; The dopamine metabolite levels and dopamine turnover rate are increased in the striata of Lmtk3(-/-) mice compared with controls. In addition, we found that LMTK3 is involved in the endocytic trafficking of N-methyl-d-aspartate receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6BLZ0;Q52KF1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5XJV6-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AHG0-1", "uniprot_id": [ { "id": "LZTS3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "external" } ], "mass": 74986.0, "length": 700, "protein_name": "Leucine zipper putative tumor suppressor 3", "gene_name": "Lzts3", "organism": "Mouse", "refseq_name": "leucine zipper putative tumor suppressor 3 isoform b", "refseq_ac": [ { "id": "NP_001277956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956", "type": "external" } ], "gene_names_uniprotkb": "Lzts3; Prosapip1", "gene_names_refseq": "Lzts3; Prosapip1", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1", "protein_names_refseq": "leucine zipper putative tumor suppressor 3 isoform b; leucine zipper putative tumor suppressor 3; proSAP-interacting protein 1; proline rich synapse associated protein interacting protein 1 (Prosapip1)", "tax_id": 10090, "disease": "", "pathway": " (mmu:241638)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22645316;28890345;31599954;34678516;34887587;40885482", "class_list": "", "function": "Data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use., [RefSeq, PubMed]; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2AHF9;Q3TSY0;Q6PE51", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0061001 regulation of dendritic spine morphogenesis;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A2AHG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60592-1", "uniprot_id": [ { "id": "MAST2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60592", "type": "external" } ], "mass": 190534.0, "length": 1734, "protein_name": "Microtubule-associated serine/threonine-protein kinase 2", "gene_name": "Mast2", "organism": "Mouse", "refseq_name": "microtubule-associated serine/threonine-protein kinase 2 isoform 1", "refseq_ac": [ { "id": "NP_001036208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036208", "type": "external" } ], "gene_names_uniprotkb": "Mast2; Mast205", "gene_names_refseq": "MAST205; Mast2; Mtssk", "protein_names_uniprotkb": "Microtubule-associated serine/threonine-protein kinase 2; 2.7.11.1", "protein_names_refseq": "microtubule associated testis specific serine/threonine protein kinase; microtubule-associated serine/threonine-protein kinase 2 isoform 1; microtubule-associated serine/threonine-protein kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17776)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10404183;14764729;15308666;17242355;21183079;21750661;28011936;31219806;34428180;8246979;8902215", "class_list": "", "function": "Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9M1;Q8CHD1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0016020 membrane;GO:0015630 microtubule cytoskeleton;GO:0070161 anchoring junction;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0032655 regulation of interleukin-12 production;GO:0048515 spermatid differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60592-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C192-1", "uniprot_id": [ { "id": "LRC4B_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C192", "type": "external" } ], "mass": 76156.0, "length": 709, "protein_name": "Leucine-rich repeat-containing protein 4B", "gene_name": "Lrrc4b", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 4B precursor", "refseq_ac": [ { "id": "NP_937893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937893", "type": "external" } ], "gene_names_uniprotkb": "Lrrc4b; Lrig4", "gene_names_refseq": "A830007M12; Lrig4; Lrrc4b; Ngl3", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4B; NGL-3; Netrin-G3 ligand", "protein_names_refseq": "NGL-3; leucine-rich repeat-containing protein 4B precursor; leucine-rich repeat-containing protein 4B; leucine-rich repeats and immunoglobulin-like domains 4; netrin-G3 ligand", "tax_id": 10090, "disease": "", "pathway": " (mmu:272381); (R-MMU-388844)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16980967;21183079;21750661;22645316;28695613;33300544;34428180", "class_list": "", "function": "NGL-3 induced differentiation of hippocampal mossy fibers. This activity of NGL-3 was dependent on afadin, but not the afadin-binding presynaptic nectin-1., [RefSeq, PubMed]; Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0044300 cerebellar mossy fiber;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P0C192-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60664-1", "uniprot_id": [ { "id": "IRAG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60664", "type": "external" } ], "mass": 59588.0, "length": 539, "protein_name": "Inositol 1,4,5-triphosphate receptor associated 2", "gene_name": "Irag2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Irag2; Jaw1; Lrmp", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol 1,4,5-triphosphate receptor associated 2; Lymphoid-restricted membrane protein; Protein Jaw1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:16970); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "20071408;21183079;21750661;29187734;29878215;30084848;32647060;34428180;8021504;8798562;9314557", "class_list": "", "function": "Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion (PubMed:9314557). Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules (PubMed:29878215). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (PubMed:32647060)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMU8", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007338 single fertilization;GO:0002376 immune system process;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60664-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C031-1", "uniprot_id": [ { "id": "LRC4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C031", "type": "external" } ], "mass": 71992.0, "length": 640, "protein_name": "Leucine-rich repeat-containing protein 4C", "gene_name": "Lrrc4c", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 4C precursor", "refseq_ac": [ { "id": "NP_001276671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276671", "type": "external" } ], "gene_names_uniprotkb": "Lrrc4c; Ngl1", "gene_names_refseq": "6430556C10Rik; Lrrc4c; NGL-1", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4C; NGL-1; Netrin-G1 ligand", "protein_names_refseq": "leucine-rich repeat-containing protein 4C precursor; leucine-rich repeat-containing protein 4C; netrin-G1 ligand", "tax_id": 10090, "disease": "", "pathway": " (mmu:241568)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14595443;15590698;21183079;21750661;30084848;30899004;33300544;34428180;4595443", "class_list": "", "function": "May promote neurite outgrowth of developing thalamic neurons., [UniProtKB, PubMed]; NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q505E5;Q8BGH8", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0099560 synaptic membrane adhesion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8C031-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11152-1", "uniprot_id": [ { "id": "LIPL_MOUSE", "url": "https://www.uniprot.org/uniprot/P11152", "type": "external" } ], "mass": 53109.0, "length": 474, "protein_name": "Lipoprotein lipase", "gene_name": "Lpl", "organism": "Mouse", "refseq_name": "lipoprotein lipase precursor", "refseq_ac": [ { "id": "NP_032535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032535", "type": "external" } ], "gene_names_uniprotkb": "Lpl", "gene_names_refseq": "Lpl", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1", "protein_names_refseq": "O 1-4-5; lipoprotein lipase precursor; phospholipase A1", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial lipoprotein lipase deficiency (Disease Ontology:DOID:14118); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16956); (R-MMU-8963889); (R-MMU-8963901); (R-MMU-975634)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12648094;1339460;17403372;1748295;1765386;18250455;20620994;24726386;25066055;26495903;26740625;2723548;27811232;31219806;34428180;3597382;37507081;37828378;8675619", "class_list": "", "function": "Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:20620994, PubMed:24726386, PubMed:27811232)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05956;Q542L4;Q9D3M9;Q9DCM8", "ec_number_list": [ { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:1904179 positive regulation of adipose tissue development;GO:0001523 retinoid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P11152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14BB9-1", "uniprot_id": [ { "id": "MA6D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14BB9", "type": "external" } ], "mass": 20433.0, "length": 191, "protein_name": "MAP6 domain-containing protein 1", "gene_name": "Map6d1", "organism": "Mouse", "refseq_name": "MAP6 domain-containing protein 1", "refseq_ac": [ { "id": "NP_941001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941001", "type": "external" } ], "gene_names_uniprotkb": "Map6d1", "gene_names_refseq": "A330066I15Rik; Map6d1", "protein_names_uniprotkb": "MAP6 domain-containing protein 1; 21 kDa STOP-like protein; SL21", "protein_names_refseq": "21 kDa STOP-like protein; MAP6 domain-containing protein 1; SL21", "tax_id": 10090, "disease": "", "pathway": " (mmu:208158)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16837464;21183079;22517741;22645316;26192747;32848054;34678516;40021952;40885482", "class_list": "", "function": "May have microtubule-stabilizing activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQE2;Q8C540", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q14BB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHZ5-1", "uniprot_id": [ { "id": "LMOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHZ5", "type": "external" } ], "mass": 62018.0, "length": 550, "protein_name": "Leiomodin-2", "gene_name": "Lmod2", "organism": "Mouse", "refseq_name": "leiomodin-2", "refseq_ac": [ { "id": "NP_444328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444328", "type": "external" } ], "gene_names_uniprotkb": "Lmod2", "gene_names_refseq": "C-Lmod; Lmod2", "protein_names_uniprotkb": "Leiomodin-2; C-LMOD; Cardiac leiomodin; Leiomodin", "protein_names_refseq": "cardiac leiomodin; leiomodin-2", "tax_id": 10090, "disease": "dilated cardiomyopathy 2G (Disease Ontology:DOID:0081163); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:93677)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11318603;17572376;21183079;25428506;26487682;27274810;30102883;31517052;37126682;38478604", "class_list": "", "function": "Data indicate that leiomodin 2 protein(Lmod2) functions to elongate actin filaments in the heart., [RefSeq, PubMed]; Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Lmod2 is necessary for effective skeletal muscle contraction., [RefSeq, PubMed]; Loss of Lmod2 in adult mice results in a rapid loss of contractile force and cardiac failure. These results indicate that Lmod2 functions to maintain thin filament length and uniformity, which contributes to proper contractile force generation., [RefSeq, PubMed]; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:26487682). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:26487682, PubMed:27274810)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PM7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0031430 M band", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030041 actin filament polymerization;GO:0045214 sarcomere organization;GO:0045010 actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UHZ5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62073-1", "uniprot_id": [ { "id": "M3K7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62073", "type": "external" } ], "mass": 64228.0, "length": 579, "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "Map3k7", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 7 isoform A", "refseq_ac": [ { "id": "NP_766276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766276", "type": "external" } ], "gene_names_uniprotkb": "Map3k7; Tak1", "gene_names_refseq": "B430101B05; Map3k7; Tak1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 7; 2.7.11.25; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1", "protein_names_refseq": "TGF-beta-activated kinase 1; mitogen-activated protein kinase kinase kinase 7 isoform A; transforming growth factor-beta-activated kinase 1", "tax_id": 10090, "disease": "frontometaphyseal dysplasia (Disease Ontology:DOID:0111785); frontometaphyseal dysplasia 2 (Disease Ontology:DOID:0111787); prostate cancer (Disease Ontology:DOID:10283); benign hypertensive renal disease (Disease Ontology:DOID:11520); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:26409); (R-MMU-168638); (R-MMU-202424); (R-MMU-2871837); (R-MMU-4086398); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-5689880); (R-MMU-9020702); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-975163)", "pathway_count": 16, "publication_count": 51, "publication_id_list": "10.1101/2023.09.13.557529;10748100;12556533;15647289;16157589;17242355;17496917;17548520;17709393;17965022;18617512;19144319;20060931;21183079;21750661;22057290;22307082;22517741;22644295;22645316;22872234;24534530;25050617;25632008;26444420;26648529;27084103;27230958;27402796;27777970;28842570;29147012;29163172;29229953;29291351;30084848;30765691;30779550;31219806;31402917;31519887;32869445;33327477;34428180;35803916;35822049;36852467;37832545;39044278;40885482;8533096", "class_list": "", "function": "Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10748100, PubMed:16157589, PubMed:21183079, PubMed:29291351). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10748100, PubMed:16157589, PubMed:21183079, PubMed:29291351). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:10748100, PubMed:16157589, PubMed:21183079, PubMed:29291351, PubMed:8533096). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (By similarity). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (By similarity). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:17965022). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (By similarity). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (By similarity). Promotes TRIM5 capsid-specific restriction activity (By similarity). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (PubMed:28842570). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 11, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "Q62073-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAM1-1", "uniprot_id": [ { "id": "LRC34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAM1", "type": "external" } ], "mass": 46635.0, "length": 415, "protein_name": "Leucine-rich repeat-containing protein 34", "gene_name": "Lrrc34", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 34", "refseq_ac": [ { "id": "NP_082217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082217", "type": "external" } ], "gene_names_uniprotkb": "Lrrc34; Spata34", "gene_names_refseq": "1700007J06Rik; Lrrc34; SPATA34", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 34", "protein_names_refseq": "leucine-rich repeat-containing protein 34; spermatogenesis associated SPATA34", "tax_id": 10090, "disease": "", "pathway": " (mmu:71827)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;24435972;24991885;31621016;32299535;34549596", "class_list": "", "function": "Authors found that the Spata34 gene KO mice had normal fertility compared with wild type mice, and no overt detectable difference was found in testis/body weight ratios, testicular histology, sperm counts and spermatozoa motility parameters between WT and Spata34 KO mice., [RefSeq, PubMed]; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro., [UniProtKB, PubMed]; LRRC34 is a novel nucleolar protein that is predominantly expressed in pluripotent stem cells., [RefSeq, PubMed]; Lrrc34 Interacts with Oct4 and Has an Impact on Telomere Length in Mouse Embryonic Stem Cells., [RefSeq, PubMed]; Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansion In Vitro., [RefSeq, PubMed]; Lrrc34 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Overexpression of Spata34 in COS7 cells inhibited the transcriptional activity of AP-1, p53 and p21 which suggested that Spata34 protein may act as a transcriptional repressor in p53 and p21 pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUN5;Q14B04", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0000723 telomere maintenance;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DAM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXZ0-1", "uniprot_id": [ { "id": "MACF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXZ0", "type": "external" } ], "mass": 831878.0, "length": 7354, "protein_name": "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4", "gene_name": "Macf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Macf1; Acf7; Aclp7; Kiaa0754; Macf", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4; Actin cross-linking family 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "lissencephaly 9 with complex brainstem malformation (Disease Ontology:DOID:0112228); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:11426)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10601340;15345747;16076900;16452087;16815997;17114649;17242355;18854161;21183079;21295697;21750661;22645316;26526844;29237092;30016717;31219806;34418053;34428180;35820727;36210013;36288343;36757814;36852467;40021952;40885482;8954775", "class_list": "", "function": "F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:16815997, PubMed:18854161, PubMed:21295697). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (PubMed:16815997). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (PubMed:18854161). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (PubMed:21295697). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (PubMed:21295697). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (PubMed:26526844)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "B1ARU3;P97394;P97395;P97396;Q4PLL5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration;GO:0016055 Wnt signaling pathway;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q9QXZ0-1", "record_type": "protein", "filter_code": "0000000.1000111.000010.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTL7-1", "uniprot_id": [ { "id": "LYPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTL7", "type": "external" } ], "mass": 24794.0, "length": 231, "protein_name": "Acyl-protein thioesterase 2", "gene_name": "Lypla2", "organism": "Mouse", "refseq_name": "acyl-protein thioesterase 2", "refseq_ac": [ { "id": "NP_036072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036072", "type": "external" } ], "gene_names_uniprotkb": "Lypla2", "gene_names_refseq": "Lypla2; LysoII", "protein_names_uniprotkb": "Acyl-protein thioesterase 2; 3.1.2.-; 3.1.2.22; APT-2; LPL-II; LysoPLA II; Lysophospholipase 2; Lysophospholipase II; Palmitoyl-protein hydrolase; mLyso II", "protein_names_refseq": "APT-2; LPL-II; acyl-protein thioesterase 2; lysoPLA II; lysophospholipase II; mLyso II; palmitoyl-protein hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26394); (R-MMU-373760)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10064901;23396970;25301951;26740625;32152506;34428180;34678516;38538834", "class_list": "", "function": "Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:38538834). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (PubMed:10064901). Hydrolyzes prostaglandin glycerol esters (PG-Gs) (PubMed:25301951). Hydrolyzes PG-Gs in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJD6", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046464 acylglycerol catabolic process;GO:1905344 prostaglandin catabolic process;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YWE6-1", "uniprot_id": [ { "id": "MN1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YWE6", "type": "external" } ], "mass": 134072.0, "length": 1297, "protein_name": "Transcriptional activator MN1", "gene_name": "Mn1", "organism": "Mouse", "refseq_name": "transcriptional activator MN1", "refseq_ac": [ { "id": "NP_001074704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074704", "type": "external" } ], "gene_names_uniprotkb": "Mn1", "gene_names_refseq": "Mn1", "protein_names_uniprotkb": "Transcriptional activator MN1", "protein_names_refseq": "meningioma 1; probable tumor suppressor protein MN1; transcriptional activator MN1", "tax_id": 10090, "disease": "meningioma (Disease Ontology:DOID:3565); familial meningioma (Disease Ontology:DOID:4586); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (mmu:433938)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15870292;16105979;17525718;18948418;19386590;33542482;33974912;34428180", "class_list": "", "function": "Important role for MN1 in maintaining the appropriate maturation and function of calvarial osteoblasts, [RefSeq, PubMed]; Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML., [RefSeq, PubMed]; Leukemogenic effect of MN1-ets variant gene 6 in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome, [RefSeq, PubMed]; MN1 overexpression is associated with the development of myeloproliferative disease, [RefSeq, PubMed]; Menin is necessary for long term maintenance of meningioma-1 driven leukemia., [RefSeq, PubMed]; Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development., [RefSeq, PubMed]; Mn1 is an important factor in development of membranous bones, [RefSeq, PubMed]; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate (PubMed:18948418). Required during later stages of palate development for normal growth and medial fusion of the palatal shelves (PubMed:18948418). Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL (PubMed:19386590). Necessary for normal development of the membranous bones of the skull (PubMed:15870292). May play a role in tumor suppression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0033689 negative regulation of osteoblast proliferation;GO:0001957 intramembranous ossification;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "D3YWE6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TN34-1", "uniprot_id": [ { "id": "MILK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TN34", "type": "external" } ], "mass": 108288.0, "length": 1009, "protein_name": "MICAL-like protein 2", "gene_name": "Micall2", "organism": "Mouse", "refseq_name": "MICAL-like protein 2", "refseq_ac": [ { "id": "NP_777275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777275", "type": "external" } ], "gene_names_uniprotkb": "Micall2; Jrab", "gene_names_refseq": "A930021H16Rik; JRAB; MICAL-L2; Micall2; mFLJ00139", "protein_names_uniprotkb": "MICAL-like protein 2; Junctional Rab13-binding protein; MICAL-L2; Molecule interacting with CasL-like 2", "protein_names_refseq": "MICAL-like protein 2; junctional Rab13-binding protein; molecule interacting with CasL-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231830)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "16525024;18094055;18332111;19144319;20008558;21183079;21540332;21750661;22645316;23100251;23890175;25428506;30016717;30059200;31488862;32782141;32848054;33976349;36852467;40021952;40885482", "class_list": "", "function": "Although actinin-4 bound to JRAB/MICAL-L2 without Rab13, the actinin-4-JRAB/MICAL-L2 interaction was enhanced by Rab13 activation., [RefSeq, PubMed]; Effector of small Rab GTPases RAB8A and RAB13 which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins (PubMed:16525024, PubMed:18094055, PubMed:20008558, PubMed:23100251, PubMed:23890175). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (PubMed:33976349)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Interaction between JRAB and filamin regulates JRABDeltaCC-induced cell spreading., [RefSeq, PubMed]; JRAB/MICAL-L2 mediates the endocytic recycling of occludin and the formation of functional TJs by linking Rab13 to actin cytoskeleton., [RefSeq, PubMed]; Rab13 and JRAB regulate reorganization of the actin cytoskeleton throughout epithelial junctional development., [RefSeq, PubMed]; Show that Rab13 regulates neurite outgrowth in the rat pheochromocytoma cell line PC12 through an interaction with JRAB/MICAL-L2., [RefSeq, PubMed]; The LIM domain, independent of the C-terminus, is necessary for the function of open-form JRAB/MICAL-L2 Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 41, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 41, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 41, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 42, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPY3;Q3UB65", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0031005 filamin binding;GO:0042805 actinin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0055037 recycling endosome;GO:0043005 neuron projection", "go_biological_process": "GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0034446 substrate adhesion-dependent cell spreading;GO:0030041 actin filament polymerization;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "Q3TN34-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30204-1", "uniprot_id": [ { "id": "MSRE_MOUSE", "url": "https://www.uniprot.org/uniprot/P30204", "type": "external" } ], "mass": 50170.0, "length": 458, "protein_name": "Macrophage scavenger receptor types I and II", "gene_name": "Msr1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Msr1; Scvr", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; SR-A; Scavenger receptor type A", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); arteriosclerosis (Disease Ontology:DOID:2349); severe acute respiratory syndrome (Disease Ontology:DOID:2945); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:20288); (R-MMU-3000480)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10722588;19144319;1978939;21750661;34418053;34428180;7666008;8380589;8394868;9348300", "class_list": "", "function": "Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense (PubMed:9348300, PubMed:10722588). Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling (PubMed:9348300, PubMed:10722588)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QNQ5;Q923G0;Q9QZ56", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0001540 amyloid-beta binding;GO:0030169 low-density lipoprotein particle binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034362 low-density lipoprotein particle;GO:0016020 membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0010629 negative regulation of gene expression;GO:0042953 lipoprotein transport;GO:0010744 positive regulation of macrophage derived foam cell differentiation;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P30204-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THE2-1", "uniprot_id": [ { "id": "ML12B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THE2", "type": "external" } ], "mass": 19779.0, "length": 172, "protein_name": "Myosin regulatory light chain 12B", "gene_name": "Myl12a; Myl12b", "organism": "Mouse", "refseq_name": "myosin regulatory light chain 12B", "refseq_ac": [ { "id": "NP_075891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075891", "type": "external" } ], "gene_names_uniprotkb": "Myl12a; Myl12b; Mrlc2; Mylc2b", "gene_names_refseq": "1500001M02Rik; MLC20; Myl12b; Mylc2b; RLC-B", "protein_names_uniprotkb": "Myosin regulatory light chain 12B; MLC20; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2", "protein_names_refseq": "myosin light chain, regulatory B; myosin regulatory light chain 12B; myosin regulatory light chain 20 kDa; myosin regulatory light chain MRLC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67938); (R-MMU-445355); (R-MMU-5627123)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "18299400;19224205;20173027;20484733;21750661;21952136;22872234;24825904;25428506;26823757;32152506;34203471;34428180;35820727;37453647;37828378", "class_list": "", "function": "Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion., [UniProtKB, UniProtKB]; Phosphorylated MYL12B may be employed as a potential plasma biomarker for the early diagnosis of sepsis induced acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVH2;Q9CQL8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0005938 cell cortex;GO:0045177 apical part of cell;GO:0001725 stress fiber", "go_biological_process": "GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q3THE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHU5-1", "uniprot_id": [ { "id": "MTCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHU5", "type": "external" } ], "mass": 213862.0, "length": 1945, "protein_name": "Microtubule cross-linking factor 1", "gene_name": "Mtcl1", "organism": "Mouse", "refseq_name": "microtubule cross-linking factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001107570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107570", "type": "external" } ], "gene_names_uniprotkb": "Mtcl1; 1110012J17Rik; Ccdc165; Kiaa0802; Soga2", "gene_names_refseq": "1110012J17Rik; Ccdc165; D130071O13; Kiaa0802; Mtcl1; Soga2; mKIAA0802; t8219b25", "protein_names_uniprotkb": "Microtubule cross-linking factor 1; Coiled-coil domain-containing protein 165; PAR-1-interacting protein; SOGA family member 2", "protein_names_refseq": "PAR-1-interacting protein; SOGA family member 2; coiled-coil domain-containing protein 165; microtubule cross-linking factor 1 isoform 1; microtubule cross-linking factor 1; protein SOGA2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68617)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23902687;28283581;30084848;34203471;34428180;40885482", "class_list": "", "function": "Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; These results indicate that MTCL1-mediated formation of stable microtubule bundles is crucial for maintenance of AnkG localization., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAM2;Q80TR7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0010506 regulation of autophagy;GO:0051301 cell division;GO:0090314 positive regulation of protein targeting to membrane;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UHU5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61216-1", "uniprot_id": [ { "id": "MRE11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61216", "type": "external" } ], "mass": 80223.0, "length": 706, "protein_name": "Double-strand break repair protein MRE11", "gene_name": "Mre11a; Mre11", "organism": "Mouse", "refseq_name": "double-strand break repair protein MRE11 isoform 2", "refseq_ac": [ { "id": "NP_001297657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297657", "type": "external" } ], "gene_names_uniprotkb": "Mre11a; Mre11; Mre11a", "gene_names_refseq": "Mre11a; Mre11b; Mre11", "protein_names_uniprotkb": "Double-strand break repair protein MRE11; 3.1.-.-; MRE11 homolog 1; MRE11 homolog A; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MmMRE11A", "protein_names_refseq": "MRE11 homolog 1; MRE11 homolog A; double-strand break repair protein MRE11 isoform 2; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A", "tax_id": 10090, "disease": "ataxia-telangiectasia-like disorder 1 (Disease Ontology:DOID:0081384); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); malignant astrocytoma (Disease Ontology:DOID:3069); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); Lynch syndrome (Disease Ontology:DOID:3883); skin cancer (Disease Ontology:DOID:4159); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:17535); (R-MMU-1834949); (R-MMU-2559586); (R-MMU-5685938); (R-MMU-5685939); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693548); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 16, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12208847;12684226;14690604;17242355;17291760;18854157;21183079;21750661;25428506;28977635;30017584;30084848;30779550;31219806;38200309;38888340;38894566;40021952;9224597", "class_list": "", "function": "Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:14690604, PubMed:17291760, PubMed:18854157). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:18854157). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:14690604, PubMed:18854157). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:18854157). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (By similarity). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (By similarity). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (By similarity). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (By similarity). MRE11 endonuclease activity is also enhanced by AGER/RAGE (PubMed:28977635). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:18854157). The MRN complex is also required for the processing of R-loops (By similarity). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (PubMed:38200309). In telomeres the MRN complex may modulate t-loop formation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Following high NaCl, Mre11 exits from the nucleus, DNA double-strand breaks accumulate in the S and G2 phases of the cell cycle, and DNA repair is inhibited., [RefSeq, PubMed]; MRE11 is essential for the long-term viability of undifferentiated spermatogonia., [RefSeq, PubMed]; Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder., [RefSeq, PubMed]; The data indicate that even subtle perturbation of Mre11 complex functions results in severe genotoxic stress, and that the complex is critically important for homeostasis of proliferative tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62430", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0004520 DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body;GO:0035861 site of double-strand break;GO:0005657 replication fork", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61216-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TL7-1", "uniprot_id": [ { "id": "MON2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TL7", "type": "external" } ], "mass": 189078.0, "length": 1715, "protein_name": "Protein MON2 homolog", "gene_name": "Mon2", "organism": "Mouse", "refseq_name": "protein MON2 homolog isoform 1", "refseq_ac": [ { "id": "NP_001156496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156496", "type": "external" } ], "gene_names_uniprotkb": "Mon2; Kiaa1040; Sf21", "gene_names_refseq": "2610528O22Rik; Mon2; Sf21; mKIAA1040", "protein_names_uniprotkb": "Protein MON2 homolog; Protein SF21", "protein_names_refseq": "protein MON2 homolog isoform 1; protein MON2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67074)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16219684;21183079;21750661;25605945;31219806;34428180", "class_list": "", "function": "Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRE3;Q8BTA8;Q8K4V3", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0006895 Golgi to endosome transport;GO:0006623 protein targeting to vacuole;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80TL7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BR76-1", "uniprot_id": [ { "id": "MKS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BR76", "type": "external" } ], "mass": 111810.0, "length": 992, "protein_name": "Meckelin", "gene_name": "Tmem67", "organism": "Mouse", "refseq_name": "meckelin precursor", "refseq_ac": [ { "id": "NP_808529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808529", "type": "external" } ], "gene_names_uniprotkb": "Tmem67; Mks3", "gene_names_refseq": "5330408M12Rik; B230117O07; Tmem67; b2b1163.1Clo; b2b1291.1Clo", "protein_names_uniprotkb": "Meckelin; Meckel syndrome type 3 protein homolog; Transmembrane protein 67", "protein_names_refseq": "meckel syndrome type 3 protein homolog; meckelin precursor; meckelin", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 3 (Disease Ontology:DOID:0070117); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Joubert syndrome 6 (Disease Ontology:DOID:0111001); nephronophthisis 11 (Disease Ontology:DOID:0111118); COACH syndrome (Disease Ontology:DOID:0111589); portal hypertension (Disease Ontology:DOID:10762); meningocele (Disease Ontology:DOID:1088); hydrocephalus (Disease Ontology:DOID:10908); coloboma (Disease Ontology:DOID:12270); nephronophthisis (Disease Ontology:DOID:12712); communicating hydrocephalus (Disease Ontology:DOID:1573); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); cystic kidney disease (Disease Ontology:DOID:2975); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:329795); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17185389;19211713;19515853;19815549;21725307;21750661;23393159;26035863;26495903;30899004;30931988;34428180", "class_list": "", "function": "Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Is a key regulator of stereociliary bundle orientation (PubMed:26035863). Required for epithelial cell branching morphology (PubMed:26035863). Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (PubMed:26035863)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/beta-catenin signalling in the developing cerebellum via Hoxb5. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q78U07", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051787 misfolded protein binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005930 axoneme;GO:0036038 MKS complex", "go_biological_process": "GO:0007507 heart development;GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BR76-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K396-1", "uniprot_id": [ { "id": "MND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K396", "type": "external" } ], "mass": 23849.0, "length": 205, "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "Mnd1", "organism": "Mouse", "refseq_name": "meiotic nuclear division protein 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_084073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084073", "type": "external" } ], "gene_names_uniprotkb": "Mnd1", "gene_names_refseq": "2610034E18Rik; Gaj; Mnd1", "protein_names_uniprotkb": "Meiotic nuclear division protein 1 homolog", "protein_names_refseq": "meiotic nuclear division protein 1 homolog isoform 1; meiotic nuclear division protein 1 homolog; meiotic nuclear divisions 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76915)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11940665;15834424;16675459;17426123;17639081;24943459;31393579", "class_list": "", "function": "Assuming the mouse model accurately reflects the impact of this variant in humans, rs140107488 appears to be a benign allele that can be eliminated or de-prioritized in clinical genomic analyses of infertility patients., [RefSeq, PubMed]; Characterization of the MND1 gene in Saccharomyces cerevisiae and identification of a potential homolog in mouse., [RefSeq, PubMed]; Data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis [Mnd1], [RefSeq, PubMed]; HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity. Publication Status: Online-Only, [RefSeq, PubMed]; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0A1", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K396-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRB9-1", "uniprot_id": [ { "id": "MIC19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRB9", "type": "external" } ], "mass": 26335.0, "length": 227, "protein_name": "MICOS complex subunit Mic19", "gene_name": "Chchd3", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic19 isoform 1", "refseq_ac": [ { "id": "NP_079612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612", "type": "external" } ], "gene_names_uniprotkb": "Chchd3; Mic19", "gene_names_refseq": "0610041L09Rik; 1700039J09Rik; Chchd3; Micos19", "protein_names_uniprotkb": "MICOS complex subunit Mic19; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3", "protein_names_refseq": "MICOS complex subunit Mic19 isoform 1; MICOS complex subunit Mic19; coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial", "tax_id": 10090, "disease": "hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:66075)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21081504;21183079;21750661;25428506;29187734;33300544;34428180;36288343;37473754;37507081;38168065", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology., [UniProtKB, UniProtKB, PubMed]; Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism., [RefSeq, PubMed]; Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0061617 MICOS complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008053 mitochondrial fusion;GO:0042407 cristae formation;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9CRB9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D273-1", "uniprot_id": [ { "id": "MMAB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D273", "type": "external" } ], "mass": 26273.0, "length": 237, "protein_name": "Corrinoid adenosyltransferase MMAB", "gene_name": "Mmab", "organism": "Mouse", "refseq_name": "corrinoid adenosyltransferase MMAB isoform 1 precursor", "refseq_ac": [ { "id": "NP_084232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084232", "type": "external" } ], "gene_names_uniprotkb": "Mmab", "gene_names_refseq": "9130222L19Rik; ATR; Mmab", "protein_names_uniprotkb": "Corrinoid adenosyltransferase MMAB; 2.5.1.-; ATP:co(I)rrinoid adenosyltransferase MMAB; Methylmalonic aciduria type B homolog", "protein_names_refseq": "ATP:co(I)rrinoid adenosyltransferase MMAB; ATP:cob(I)alamin adenosyltransferase; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; cob(II)alamin adenosyltransferase; cob(II)yrinic acid a,c-diamide adenosyltransferase; cobinamide/cobalamin adenosyltransferase; corrinoid adenosyltransferase MMAB isoform 1 precursor; corrinoid adenosyltransferase MMAB; methylmalonic aciduria (cobalamin deficiency) type B homolog", "tax_id": 10090, "disease": "methylmalonic acidemia cblB type (Disease Ontology:DOID:0060743); methylmalonic acidemia (Disease Ontology:DOID:14749); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:77697); (R-MMU-9759218)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;23022071;23576753;23806337;36288343", "class_list": "", "function": "Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA., [UniProtKB, UniProtKB]; The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFL6;Q8CBZ0;Q8VBZ4", "ec_number_list": [ { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031419 cobalamin binding;GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0008817 corrinoid adenosyltransferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009235 cobalamin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D273-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCS2-1", "uniprot_id": [ { "id": "MTL26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCS2", "type": "external" } ], "mass": 22687.0, "length": 204, "protein_name": "Methyltransferase-like 26", "gene_name": "Mettl26", "organism": "Mouse", "refseq_name": "methyltransferase-like 26", "refseq_ac": [ { "id": "NP_080962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080962", "type": "external" } ], "gene_names_uniprotkb": "Mettl26; 0610011F06Rik", "gene_names_refseq": "0610011F06Rik; Mettl26", "protein_names_uniprotkb": "Methyltransferase-like 26", "protein_names_refseq": "UPF0585 protein C16orf13 homolog; methyltransferase-like 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:68347)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIB0-1", "uniprot_id": [ { "id": "MOG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIB0", "type": "external" } ], "mass": 20413.0, "length": 185, "protein_name": "Ran guanine nucleotide release factor", "gene_name": "Rangrf", "organism": "Mouse", "refseq_name": "ran guanine nucleotide release factor isoform 1", "refseq_ac": [ { "id": "NP_001272370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272370", "type": "external" } ], "gene_names_uniprotkb": "Rangrf; Mog1; Rangnrf", "gene_names_refseq": "2400006H24Rik; Mog1; Rangnrf; Rangrf", "protein_names_uniprotkb": "Ran guanine nucleotide release factor; Ran-binding protein MOG1; RanGNRF", "protein_names_refseq": "ran guanine nucleotide release factor isoform 1; ran-binding protein MOG1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57785)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10811801;11733047;15716349;18184654;23420830;35533905", "class_list": "", "function": "In cardiomyocytes, MOG1 is mostly localized in the cell membrane and co-localized with Nav1.5, indicating that MOG1 is a critical regulator of sodium channel function in the heart, [RefSeq, PubMed]; May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWZ0", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0099103 channel activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0006913 nucleocytoplasmic transport;GO:0090307 mitotic spindle assembly;GO:2000010 positive regulation of protein localization to cell surface;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIB0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM52-1", "uniprot_id": [ { "id": "MINK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM52", "type": "external" } ], "mass": 147295.0, "length": 1308, "protein_name": "Misshapen-like kinase 1", "gene_name": "Mink1", "organism": "Mouse", "refseq_name": "misshapen-like kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_057922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057922", "type": "external" } ], "gene_names_uniprotkb": "Mink1; Map4k6; Mink", "gene_names_refseq": "B55; MINK; Map4k6; Mink1; Ysk2", "protein_names_uniprotkb": "Misshapen-like kinase 1; 2.7.11.1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6", "protein_names_refseq": "GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIKs-related kinase; Yeast Sps1/Ste20-related kinase 2; misshapen-like kinase 1 isoform 1; misshapen/NIK-related kinase", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:50932); (R-MMU-2559580)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10708748;15608642;16452087;19144319;21183079;21750661;22645316;24129315;27631493;28400474;31647983;33300544;38723371;40885482", "class_list": "", "function": "A critical regulator of Th17 cell differentiation, [RefSeq, PubMed]; Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling., [RefSeq, PubMed]; MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration., [RefSeq, PubMed]; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (PubMed:15608642). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5SXG2;Q921M6;Q9JM92", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0046330 positive regulation of JNK cascade;GO:0070050 neuron cellular homeostasis;GO:0000165 MAPK cascade;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9JM52-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVL5-1", "uniprot_id": [ { "id": "MORC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVL5", "type": "external" } ], "mass": 108310.0, "length": 950, "protein_name": "MORC family CW-type zinc finger protein 1", "gene_name": "Morc1", "organism": "Mouse", "refseq_name": "MORC family CW-type zinc finger protein 1", "refseq_ac": [ { "id": "NP_034946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034946", "type": "external" } ], "gene_names_uniprotkb": "Morc1; Morc", "gene_names_refseq": "Morc1; Morc", "protein_names_uniprotkb": "MORC family CW-type zinc finger protein 1; Protein microrchidia", "protein_names_refseq": "MORC family CW-type zinc finger protein 1; protein microrchidia", "tax_id": 10090, "disease": "melancholic depression (Disease Ontology:DOID:1595)", "pathway": " (mmu:17450)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10369865;25503965;26275923;28315936;30084848;38502704", "class_list": "", "function": "MORC1 represses transposable elements in the mouse male germline. Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604. PMID: 26159654] Publication Status: Online-Only, [RefSeq, PubMed]; Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes., [RefSeq, PubMed]; Morc1-/- mice display increased depressive-like behavior; a promising novel mouse model for depression., [RefSeq, PubMed]; Required for spermatogenesis (PubMed:10369865, PubMed:25503965). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965). Not required for piRNA biosynthesis (PubMed:25503965)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0001662 behavioral fear response;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVL5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SUA5-1", "uniprot_id": [ { "id": "MYO1G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SUA5", "type": "external" } ], "mass": 117227.0, "length": 1024, "protein_name": "Unconventional myosin-Ig", "gene_name": "Myo1g", "organism": "Mouse", "refseq_name": "unconventional myosin-Ig", "refseq_ac": [ { "id": "NP_848534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848534", "type": "external" } ], "gene_names_uniprotkb": "Myo1g", "gene_names_refseq": "E430002D17Rik; Myo1g", "protein_names_uniprotkb": "Unconventional myosin-Ig", "protein_names_refseq": "myosin 1G; myosin-Ig; unconventional myosin-Ig", "tax_id": 10090, "disease": "", "pathway": " (mmu:246177)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12486594;19968988;20071333;21750661;23038771;24310084;25083865;25605945;27106882;29187734;31219806;33785780;34428180;39627609;40021952", "class_list": "", "function": "Data propose that Myo1G regulates cell elasticity by deformations of the actin network at the cell cortex., [RefSeq, PubMed]; Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes. Publication Status: Online-Only, [RefSeq, PubMed]; Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes., [RefSeq, PubMed]; Study found that the unconventional myosin 1g (Myo1g) motor generates membrane tension, enforces cell-intrinsic meandering search, and enhances T-DC interactions during lymph-node surveillance. Increased turning and meandering motility, as opposed to ballistic motility, is enhanced by Myo1g. Myo1g acts as a 'turning motor' and generates a form of cellular 'flanerie.', [RefSeq, PubMed]; The results described here reveal a novel molecular mechanism by which Myo1g mediates and regulates cell stiffness in B-lymphocytes., [RefSeq, PubMed]; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration (PubMed:25083865). Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication (PubMed:25083865). Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes (PubMed:24310084). Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis (PubMed:23038771)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIT8;Q8BJ17;Q8BJ65;Q8R019;Q91ZI1", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0030048 actin filament-based movement;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q5SUA5-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08551-1", "uniprot_id": [ { "id": "NFL_MOUSE", "url": "https://www.uniprot.org/uniprot/P08551", "type": "external" } ], "mass": 61508.0, "length": 543, "protein_name": "Neurofilament light polypeptide", "gene_name": "Nefl", "organism": "Mouse", "refseq_name": "neurofilament light polypeptide", "refseq_ac": [ { "id": "NP_035040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035040", "type": "external" } ], "gene_names_uniprotkb": "Nefl; Nf68; Nfl", "gene_names_refseq": "CMT2E; NF-L; NF68; Nefl; Nfl", "protein_names_uniprotkb": "Neurofilament light polypeptide; 68 kDa neurofilament protein; NF-L; Neurofilament triplet L protein", "protein_names_refseq": "68 kDa neurofilament protein; neurofilament light polypeptide; neurofilament triplet L protein", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); fatal familial insomnia (Disease Ontology:DOID:0050433); stroke (Disease Ontology:DOID:0051061); Charcot-Marie-Tooth disease dominant intermediate G (Disease Ontology:DOID:0080294); COVID-19 (Disease Ontology:DOID:0080600); mild cognitive impairment (Disease Ontology:DOID:0080832); Charcot-Marie-Tooth disease type 1F (Disease Ontology:DOID:0110149); Charcot-Marie-Tooth disease type 2E (Disease Ontology:DOID:0110165); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Lewy body dementia (Disease Ontology:DOID:12217); Sjogren's syndrome (Disease Ontology:DOID:12894); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); invasive ductal carcinoma (Disease Ontology:DOID:3008); demyelinating disease (Disease Ontology:DOID:3213); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); syphilis (Disease Ontology:DOID:4166); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); progressive multifocal leukoencephalopathy (Disease Ontology:DOID:643); vascular dementia (Disease Ontology:DOID:8725); neuromyelitis optica (Disease Ontology:DOID:8869); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:18039); (R-MMU-438066); (R-MMU-5673001)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "16236762;16452087;16452088;1717455;18034455;18687884;19458039;2246261;22517741;22645316;22723690;22872234;24129315;28657654;29237092;30031227;3103856;32848054;33300544;34428180;34678516;35822049;3785173;3919033;40021952;40684658;40885482", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0Z0", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030426 growth cone;GO:0031594 neuromuscular junction;GO:0043209 myelin sheath", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0045110 intermediate filament bundle assembly;GO:0021510 spinal cord development;GO:0050885 neuromuscular process controlling balance;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P08551-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04690-1", "uniprot_id": [ { "id": "NF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04690", "type": "external" } ], "mass": 319596.0, "length": 2841, "protein_name": "Neurofibromin", "gene_name": "Nf1", "organism": "Mouse", "refseq_name": "neurofibromin", "refseq_ac": [ { "id": "NP_035027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035027", "type": "external" } ], "gene_names_uniprotkb": "Nf1", "gene_names_refseq": "Dsk9; E030030H24Rik; Mhdadsk9; Nf-1; Nf1", "protein_names_uniprotkb": "Neurofibromin; Neurofibromatosis-related protein NF-1", "protein_names_refseq": "neurofibromatosis 1; neurofibromatosis-related protein NF-1; neurofibromin", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:18015); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10671200;21183079;2169593;21750661;22118770;25605945;30016717;30084848;33300544;34418053;34428180;7958951;8353485", "class_list": "", "function": "Stimulates the GTPase activity of Ras (By similarity). NF1 shows greater affinity for Ras GAP, but lower specific activity (By similarity). May be a regulator of Ras activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61956;Q61957", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008017 microtubule binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0045545 syndecan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0046580 negative regulation of Ras protein signal transduction;GO:0048820 hair follicle maturation;GO:0001889 liver development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q04690-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SYD0-1", "uniprot_id": [ { "id": "MYO1D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SYD0", "type": "external" } ], "mass": 116081.0, "length": 1006, "protein_name": "Unconventional myosin-Id", "gene_name": "Myo1d", "organism": "Mouse", "refseq_name": "unconventional myosin-Id", "refseq_ac": [ { "id": "NP_796364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796364", "type": "external" } ], "gene_names_uniprotkb": "Myo1d", "gene_names_refseq": "9930104H07Rik; D11Ertd9e; Myo1d; myosin-1d", "protein_names_uniprotkb": "Unconventional myosin-Id", "protein_names_refseq": "myosin-Id; unconventional myosin-Id", "tax_id": 10090, "disease": "", "pathway": " (mmu:338367)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18034455;20089841;22872234;29559226;30279225;33300544;34203471;34428180;34459138;34887587;36210013", "class_list": "", "function": "MYO1D is needed to maintain epithelial integrity and protect against dextran sodium sulfate-induced colitis. Publication Status: Online-Only, [RefSeq, PubMed]; New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D., [RefSeq, PubMed]; These findings reveal that myosin Id localizes in dendritic spines through the TH1 domain., [RefSeq, PubMed]; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSK7;Q8BWY5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030048 actin filament-based movement;GO:0061502 early endosome to recycling endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5SYD0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z64-1", "uniprot_id": [ { "id": "NANOG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Z64", "type": "external" } ], "mass": 34240.0, "length": 305, "protein_name": "Homeobox protein NANOG", "gene_name": "Nanog", "organism": "Mouse", "refseq_name": "homeobox protein NANOG isoform 2", "refseq_ac": [ { "id": "NP_001276757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276757", "type": "external" } ], "gene_names_uniprotkb": "Nanog; Ecat4; Enk", "gene_names_refseq": "2410002E02Rik; ENK; Nanog; Stm1; ecat4", "protein_names_uniprotkb": "Homeobox protein NANOG; ES cell-associated protein 4; Early embryo specific expression NK-type homeobox protein; Homeobox transcription factor Nanog", "protein_names_refseq": "ES cell-associated protein 4; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; homeobox protein NANOG isoform 2; homeobox protein NANOG; homeobox transcription factor Nanog", "tax_id": 10090, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:71950)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "12609610;12787504;12787505;14728807;15108323;15502159;15582778;15619621;15939376;16518401;16790525;16791199;16801560;16840789;18177668;18957414;19483677;21149613;21915945;22988117;25428506;25825768;27311888;33107035;35820727;36852467", "class_list": "glycogene", "function": "Nanog is a homeodomain protein whose enhanced expression confers constitutive self-renewal on ES cells. Forced expression of Nanog liberates ES cells from the requirement for gp130 stimulation., [RefSeq, PubMed]; The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6SMR1;Q7TN85", "ec_number_list": [], "go_molecular_function": "GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0009825 multidimensional cell growth;GO:0001714 endodermal cell fate specification;GO:0072752 cellular response to rapamycin;GO:0001710 mesodermal cell fate commitment;GO:0010454 negative regulation of cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q80Z64-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C119-1", "uniprot_id": [ { "id": "NDNF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C119", "type": "external" } ], "mass": 65027.0, "length": 568, "protein_name": "Protein NDNF", "gene_name": "Ndnf", "organism": "Mouse", "refseq_name": "protein NDNF precursor", "refseq_ac": [ { "id": "NP_765987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765987", "type": "external" } ], "gene_names_uniprotkb": "Ndnf", "gene_names_refseq": "A930038C07Rik; Ndnf; epidermacan", "protein_names_uniprotkb": "Protein NDNF; Epidermacan; Neuron-derived neurotrophic factor", "protein_names_refseq": "fibronectin type-III domain-containing protein C4orf31 homolog; protein NDNF precursor; protein NDNF", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070)", "pathway": " (mmu:68169)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18757743;20969804;24706764;31883645", "class_list": "", "function": "Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (PubMed:18757743). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80VN3;Q8BWV6", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0010976 positive regulation of neuron projection development;GO:0030198 extracellular matrix organization;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C119-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIM5-1", "uniprot_id": [ { "id": "MYCD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIM5", "type": "external" } ], "mass": 101400.0, "length": 935, "protein_name": "Myocardin", "gene_name": "Myocd", "organism": "Mouse", "refseq_name": "myocardin isoform A", "refseq_ac": [ { "id": "NP_660118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660118", "type": "external" } ], "gene_names_uniprotkb": "Myocd; Bsac2; Mycd; Srfcp", "gene_names_refseq": "BSAC2A; Myocd; Srfcp", "protein_names_uniprotkb": "Myocardin; Basic SAP coiled-coil transcription activator 2; SRF cofactor protein", "protein_names_refseq": "SRF co-factor protein (cardiac and smooth muscle); SRF cofactor protein; basic SAP coiled-coil transcription activator 2; myocardin isoform A", "tax_id": 10090, "disease": "congenital megabladder (Disease Ontology:DOID:0112014); aortic atherosclerosis (Disease Ontology:DOID:10230); dilated cardiomyopathy (Disease Ontology:DOID:12930); patent ductus arteriosus (Disease Ontology:DOID:13832); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:214384)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11439182;12397177;12640126;12663482;14645532;15601857;16141410;16818234;19237536;19776005;20385216;21750661;31513549;33743134", "class_list": "", "function": "Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells, [RefSeq, PubMed]; Positively regulates the activation of smooth muscle cell gene promoter regions (PubMed:20385216). Activation of the MYH6 promoter is enhanced in the presence of MEF2C (PubMed:20385216)., [UniProtKB, PubMed]; Positively regulates the activation of smooth muscle cell gene promoter regions., [UniProtKB, PubMed]; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SS65;Q6W8X1;Q8C3W6;Q8VIL4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042826 histone deacetylase binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0070412 R-SMAD binding;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0070514 SRF-myogenin-E12 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0001560 regulation of cell growth by extracellular stimulus;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0035733 hepatic stellate cell activation;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0003231 cardiac ventricle development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8VIM5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTI7-1", "uniprot_id": [ { "id": "MYO1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTI7", "type": "external" } ], "mass": 121944.0, "length": 1063, "protein_name": "Unconventional myosin-Ic", "gene_name": "Myo1c", "organism": "Mouse", "refseq_name": "unconventional myosin-Ic isoform b", "refseq_ac": [ { "id": "NP_001074243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074243", "type": "external" } ], "gene_names_uniprotkb": "Myo1c", "gene_names_refseq": "MMIb; MYO1E; Myo1c; NMI; mm1beta; myr2", "protein_names_uniprotkb": "Unconventional myosin-Ic; MMI-beta; MMIb; Myosin I beta", "protein_names_refseq": "MMI-beta; myosin I beta; myosin-Ibeta; myosin-Ic; nuclear myosin I beta; unconventional myosin-Ic isoform b; unconventional myosin-Ic", "tax_id": 10090, "disease": "", "pathway": " (mmu:17913); (R-MMU-2029482); (R-MMU-5250924)", "pathway_count": 3, "publication_count": 36, "publication_id_list": "11030652;11853671;12490950;14980509;15014434;15976448;16102537;16492791;16514417;16957816;16960872;16971510;17994197;21183079;21750661;22872234;22918957;23806337;25428506;26961175;27802388;29187734;30059200;31219806;33965643;34203471;34428180;34887587;36064721;36210013;37507081;37828378;39627609;8449986;9119401;9182797", "class_list": "", "function": "Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation., [UniProtKB, PubMed]; Myosin 1c: A novel regulator of glucose uptake in brown adipocytes., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes., [UniProtKB, PubMed]; This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08571;O08834;Q3TBQ4;Q3U231;Q5ND46;Q5ND48;Q5ND49;Q9ERB6;Q9QW54", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0006338 chromatin remodeling;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9WTI7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN1-1", "uniprot_id": [ { "id": "TXLNG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN1", "type": "external" } ], "mass": 60309.0, "length": 524, "protein_name": "Gamma-taxilin", "gene_name": "Txlng", "organism": "Mouse", "refseq_name": "gamma-taxilin isoform 2", "refseq_ac": [ { "id": "NP_001277705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277705", "type": "external" } ], "gene_names_uniprotkb": "Txlng; Lrg", "gene_names_refseq": "4932441K18Rik; Fiat; Lrp; Txlng", "protein_names_uniprotkb": "Gamma-taxilin; FIAT; Factor inhibiting ATF4-mediated transcription; Lipopolysaccharide-responsive gene protein", "protein_names_refseq": "factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; gamma-taxilin isoform 2; gamma-taxilin; lipopolysaccharide-responsive gene protein; lipopolysaccharide-specific response protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:353170)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15911876;17242355;19016261;19232401;19913514;20392257;21183079;21750661;23463631;24375853;24440290;27906582;29949140;34428180", "class_list": "", "function": "An interplay between Sp1 and Sp3 as a mechanism involved in the control of Fiat gene expression in osteoblasts., [RefSeq, PubMed]; FIAT can both modulate early osteoblast activity by interacting with ATF4 and regulate later osteoblast function through inhibition of FRA-1., [RefSeq, PubMed]; Inhibition of FIAT expression increases ATF4 activity and confirm the important role of FIAT in osteoblast function, [RefSeq, PubMed]; May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression., [UniProtKB, PubMed, PubMed, PubMed]; Negative regulator of bone mass acting distinctly on bone formation without alteration in resorption and affecting both the trabecular and the cortical compartments, [RefSeq, PubMed]; Our study showed that miR-98 was an important regulator in osteoblast mineralization and miR-98 carried out its function through a novel miR-98-FIAT/Sp7 regulatory loop, [RefSeq, PubMed]; The bone phenotype of compound Naca(+/-); Fiat(+/-) heterozygotes confirms that FIAT and alphaNAC are part of a common genetic pathway and support a role for the FIAT/alphaNAC interaction in normal bone physiology., [RefSeq, PubMed]; These results show that FIAT regulates bone mass accrual and establish FIAT as a novel transcriptional regulator of osteoblastic function.(FIAT protein, mouse), [RefSeq, PubMed]; Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with gram-negative bacteria ., [RefSeq, PubMed]; We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2-interacting aNAC, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFJ5;Q148Z8;Q2LGB1;Q2PMX1;Q8BP11", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030500 regulation of bone mineralization;GO:0010564 regulation of cell cycle process;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BHN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V24-1", "uniprot_id": [ { "id": "VGLL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V24", "type": "external" } ], "mass": 30999.0, "length": 287, "protein_name": "Transcription cofactor vestigial-like protein 4", "gene_name": "Vgll4", "organism": "Mouse", "refseq_name": "transcription cofactor vestigial-like protein 4 isoform 1", "refseq_ac": [ { "id": "NP_808351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808351", "type": "external" } ], "gene_names_uniprotkb": "Vgll4", "gene_names_refseq": "VGL-4; Vgll4", "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 4; Vgl-4", "protein_names_refseq": "transcription cofactor vestigial-like protein 4 isoform 1; transcription cofactor vestigial-like protein 4; vestigial like 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:232334)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15140898;21750661;27720608;30119884;32782141;37921465", "class_list": "", "function": "Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma in a mouse model with G2/M phase arrest and apoptosis promotion., [RefSeq, PubMed]; Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease., [RefSeq, PubMed]; May act as a specific coactivator for the mammalian TEFs., [UniProtKB, UniProtKB, UniProtKB]; VGLL4 inhibits cardiomyocyte proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation., [RefSeq, PubMed]; Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0030178 negative regulation of Wnt signaling pathway;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80V24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35918-1", "uniprot_id": [ { "id": "VGFR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35918", "type": "external" } ], "mass": 150462.0, "length": 1345, "protein_name": "Vascular endothelial growth factor receptor 2", "gene_name": "Kdr", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor receptor 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034742", "type": "external" } ], "gene_names_uniprotkb": "Kdr; Flk-1; Flk1", "gene_names_refseq": "6130401C07; Flk-1; Flk1; Kdr; Krd-1; Ly73; VEGFR-2; VEGFR2; orv; sVEGFR-2", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 2; 2.7.10.1; FLK-1; Fetal liver kinase 1; Kinase NYK; Protein-tyrosine kinase receptor flk-1; VEGFR-2", "protein_names_refseq": "VEGF receptor-2; fetal liver kinase 1; kinase NYK; protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 2 isoform 1 precursor; vascular endothelial growth factor receptor-3", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); salivary gland carcinoma (Disease Ontology:DOID:0050904); stroke (Disease Ontology:DOID:0051061); brain glioma (Disease Ontology:DOID:0060108); colitis (Disease Ontology:DOID:0060180); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoma (Disease Ontology:DOID:1115); retinopathy of prematurity (Disease Ontology:DOID:13025); adhesions of uterus (Disease Ontology:DOID:13812); lymphangioma (Disease Ontology:DOID:1475); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); hemangiopericytoma (Disease Ontology:DOID:264); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); inverted papilloma (Disease Ontology:DOID:3179); neurilemmoma (Disease Ontology:DOID:3192); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); breast angiosarcoma (Disease Ontology:DOID:4511); pancreatic carcinoma (Disease Ontology:DOID:4905); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal telangiectasia (Disease Ontology:DOID:7736); ulcerative colitis (Disease Ontology:DOID:8577); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16542); (R-MMU-194306); (R-MMU-195399); (R-MMU-4420097); (R-MMU-5218921)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10878616;11387210;11465105;12023952;12796773;12881528;15026417;15673613;1717995;17702744;18250455;19635461;19652084;19668192;20705758;21183079;26495903;27802388;27966990;31599954;34428180;7559454;7596435;7681362;8356051;8423988", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 77, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 14, "disease_count": 63, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "C5H7S5;Q8VCD0", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005178 integrin binding;GO:0005524 ATP binding;GO:0015026 coreceptor activity;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:1903010 regulation of bone development;GO:0035162 embryonic hemopoiesis;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P35918-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51960-1", "uniprot_id": [ { "id": "MYBA_MOUSE", "url": "https://www.uniprot.org/uniprot/P51960", "type": "external" } ], "mass": 85728.0, "length": 751, "protein_name": "Myb-related protein A", "gene_name": "Mybl1", "organism": "Mouse", "refseq_name": "myb-related protein A isoform 1", "refseq_ac": [ { "id": "NP_032677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032677", "type": "external" } ], "gene_names_uniprotkb": "Mybl1; Amyb", "gene_names_refseq": "A-myb; G1-419-6; Mybl1; repro9", "protein_names_uniprotkb": "Myb-related protein A; A-Myb; Myb-like protein 1", "protein_names_refseq": "myb-like protein 1; myb-related protein A isoform 1; myb-related protein A; myeloblastosis oncogene-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17864)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750041;21750661;23523368;29848638;31219806;32895557;36497007;7813437;8084617", "class_list": "", "function": "LncRNA ENSMUST00000171502 Induced by HIF-1alpha Ameliorates Ischemic Acute Kidney Injury via Targeting the miR-130b-3p/Mybl-1 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition., [RefSeq, PubMed]; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:23523368, PubMed:7813437). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1 (PubMed:21750041, PubMed:23523368). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (PubMed:23523368). Transcriptional activator of SOX30 (PubMed:29848638)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P51960-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZN7-1", "uniprot_id": [ { "id": "MYOF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZN7", "type": "external" } ], "mass": 233324.0, "length": 2048, "protein_name": "Myoferlin", "gene_name": "Myof", "organism": "Mouse", "refseq_name": "myoferlin isoform 2", "refseq_ac": [ { "id": "NP_001093104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093104", "type": "external" } ], "gene_names_uniprotkb": "Myof; Fer1l3; Kiaa1207", "gene_names_refseq": "2310004N10Rik; 2310051D19Rik; E030042N20Rik; Fer1l3; Myof", "protein_names_uniprotkb": "Myoferlin; Fer-1-like protein 3", "protein_names_refseq": "fer-1-like protein 3; myoferlin isoform 2", "tax_id": 10090, "disease": "limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); hereditary angioedema (Disease Ontology:DOID:14735)", "pathway": " (mmu:226101)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11959863;16280346;17702744;18502764;19131326;19144319;20008164;20571050;21177873;21183079;21750661;22645316;23806337;31219806;34354129;34428180;35984564;37828378;39927985", "class_list": "", "function": "Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin), [RefSeq, PubMed]; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; IGF1 receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1, [RefSeq, PubMed]; Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; Increased expression in myofibres after muscle injury and in a mouse model of muscular dystrophy, [RefSeq, PubMed]; Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Myoferlin forms a complex with dynamin-2 and VEGFR-2, which prevents CBL-dependent VEGFR-2 polyubiquitination and proteasomal degradation., [RefSeq, PubMed]; Myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes., [RefSeq, PubMed]; The protein encoded by this gene is a member of the ferlin family of proteins, which have been implicated in fusion events in muscle tissue. Members of this family have a carboxy-terminal single pass transmembrane domain and multiple C2 domains, which bind negatively charged phospholipids in the presence of calcium ions. This gene is expressed at high levels in myoblasts and upregulated in damaged skeletal muscle. Mice deficient in this protein display defects in myoblast fusion, muscle regeneration, and angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMG0;Q80V33;Q8BU64;Q8BU70;Q8BUC1;Q8BVY6;Q8C0D1;Q8R3B4", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0031965 nuclear membrane;GO:0031410 cytoplasmic vesicle;GO:0031902 late endosome membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0034605 cellular response to heat;GO:0061025 membrane fusion;GO:0033292 T-tubule organization;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q69ZN7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYJ6-1", "uniprot_id": [ { "id": "TBCD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYJ6", "type": "external" } ], "mass": 147451.0, "length": 1307, "protein_name": "TBC1 domain family member 4", "gene_name": "Tbc1d4", "organism": "Mouse", "refseq_name": "TBC1 domain family member 4 isoform 3", "refseq_ac": [ { "id": "NP_001074747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074747", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d4; As160; Kiaa0603", "gene_names_refseq": "5930406J04Rik; A930035N22; As160; Tbc1d4", "protein_names_uniprotkb": "TBC1 domain family member 4; AS160; Akt substrate of 160 kDa", "protein_names_refseq": "TBC1 domain family member 4 isoform 3; akt substrate of 160 kDa", "tax_id": 10090, "disease": "acanthosis nigricans (Disease Ontology:DOID:3138)", "pathway": " (mmu:210789)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;11994271;12637568;15254270;16804075;16804077;18276765;21183079;21750661;22318952;22418434;24101676;24129315;25428506;25552597;25923736;28135057;29662023;30210362;31219806;33872597;34428180;36210013;36707786;37074686;38608276", "class_list": "", "function": "AS160 was shown to be a substrate for Akt, and two sites of phosphorylation, both in RXRXXS/T motifs, were identified by mass spectrometry and mutation, [RefSeq, PubMed]; Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance., [RefSeq, PubMed]; May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity)., [UniProtKB]; TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization After Exercise and Contraction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q149C0;Q149C1;Q3T9E8;Q3TAQ5;Q5DU23;Q66JU2;Q6P2M2;Q8BMH6;Q8BXM2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0031982 vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0016192 vesicle-mediated transport;GO:0031339 negative regulation of vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8BYJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJA3-1", "uniprot_id": [ { "id": "HMBX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJA3", "type": "external" } ], "mass": 47116.0, "length": 419, "protein_name": "Homeobox-containing protein 1", "gene_name": "Hmbox1", "organism": "Mouse", "refseq_name": "homeobox-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001334555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334555", "type": "external" } ], "gene_names_uniprotkb": "Hmbox1", "gene_names_refseq": "F830020C16Rik; Hmbox1", "protein_names_uniprotkb": "Homeobox-containing protein 1", "protein_names_refseq": "homeobox-containing protein 1 isoform 1; homeobox-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:219150)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23685356;31583496;36174712;37208615", "class_list": "", "function": "Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity). Might also be involved in the DNA damage response at telomeres (By similarity)., [UniProtKB, UniProtKB, PubMed]; Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HMBOX1 participated in the functional maintenance of mouse aortic endothelial cells, the aortic endothelial cells of HMBOX1 KO mouse showed increased apoptosis and decreased autophagy with lipopolysaccharidetreatment., [RefSeq, PubMed]; Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS. Publication Status: Online-Only, [RefSeq, PubMed]; N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80WC2;Q8BWE7;Q99LV1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042162 telomeric DNA binding;GO:0044877 protein-containing complex binding;GO:0003691 double-stranded telomeric DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:1905324 telomere-telomerase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BJA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDB0-1", "uniprot_id": [ { "id": "MKNK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDB0", "type": "external" } ], "mass": 51633.0, "length": 459, "protein_name": "MAP kinase-interacting serine/threonine-protein kinase 2", "gene_name": "Mknk2", "organism": "Mouse", "refseq_name": "MAP kinase-interacting serine/threonine-protein kinase 2 isoform a", "refseq_ac": [ { "id": "NP_067437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067437", "type": "external" } ], "gene_names_uniprotkb": "Mknk2; Mnk2", "gene_names_refseq": "2010016G11Rik; Gprk7; Mknk2; Mnk2", "protein_names_uniprotkb": "MAP kinase-interacting serine/threonine-protein kinase 2; 2.7.11.1; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2", "protein_names_refseq": "G protein-coupled receptor kinase 7; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform a; MAP kinase-interacting serine/threonine-protein kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17347)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11154262;15254222;16162500;17689282;17903173;20574055;20679220;20823271;20927323;21183079;21750661;30779550;31219806;34428180;35608154;9155017", "class_list": "", "function": "MNK1 and MNK2 are kinases involved in anti-apoptotic signaling in response to serum withdrawal, [RefSeq, PubMed]; MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling., [RefSeq, PubMed]; Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development, [RefSeq, PubMed]; Oncogenic role for Mnk1/2 in tumor development, [RefSeq, PubMed]; Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation., [RefSeq, PubMed]; Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]., [RefSeq]; The roles of features in the catalytic domains and C termini in determining the regulatory properties and basal activities of Mnk1 AND Mnk2 are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08606;Q75PY0;Q9D893", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006417 regulation of translation;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0030097 hemopoiesis;GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CDB0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61581-1", "uniprot_id": [ { "id": "IBP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61581", "type": "external" } ], "mass": 28969.0, "length": 281, "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "Igfbp7", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 7 isoform 2 precursor", "refseq_ac": [ { "id": "NP_032074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032074", "type": "external" } ], "gene_names_uniprotkb": "Igfbp7; Mac25", "gene_names_refseq": "AGM; Fstl2; Igfbp7; Mac25", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; MAC25 protein", "protein_names_refseq": "IBP-7; IGF-binding protein 7; IGFBP-7; angiomodulin; insulin-like growth factor-binding protein 7 isoform 2 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:29817); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10623583;10859029;11112448;18772245;21750661;26495903;34428180;37270777;38218180;38840498;8649839", "class_list": "", "function": "Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury., [RefSeq, PubMed]; METTL3-mediated m[6]A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis., [RefSeq, PubMed]; Structural insight into CD93 recognition by IGFBP7., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88812;Q9EQW0", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0001558 regulation of cell growth;GO:0009966 regulation of signal transduction;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61581-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWH1-1", "uniprot_id": [ { "id": "PHC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWH1", "type": "external" } ], "mass": 89799.0, "length": 850, "protein_name": "Polyhomeotic-like protein 2", "gene_name": "Phc2", "organism": "Mouse", "refseq_name": "polyhomeotic-like protein 2 isoform B", "refseq_ac": [ { "id": "NP_001182012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182012", "type": "external" } ], "gene_names_uniprotkb": "Phc2; Edr2; Ph2", "gene_names_refseq": "A3galt2; D130050K19Rik; D4Ertd810e; Edr2; Mph2; Phc2; p36", "protein_names_uniprotkb": "Polyhomeotic-like protein 2; Early development regulatory protein 2; mPH2; p36", "protein_names_refseq": "early development regulator 2; early development regulatory protein 2; polyhomeotic 2 protein; polyhomeotic-like 2; polyhomeotic-like protein 2 isoform B; polyhomeotic-like protein 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:54383); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "12034499;15580621;16024804;21750661;22872859;27827373;28900001;31219806;31375680;33603070;34428180;40885482;9627119", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility., [UniProtKB, PubMed]; Study demonstrates that Phc2 regulates hematopoietic stem and progenitor cells mobilization through the repression of Vcam1 expression by enhancing both H3K27me3 and H2AK119ub in bone marrow stromal cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AS98;B1ASA4;O88463;Q8K5D9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000792 heterochromatin;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QWH1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U28-1", "uniprot_id": [ { "id": "MADD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U28", "type": "external" } ], "mass": 175180.0, "length": 1577, "protein_name": "MAP kinase-activating death domain protein", "gene_name": "Madd", "organism": "Mouse", "refseq_name": "MAP kinase-activating death domain protein isoform 10", "refseq_ac": [ { "id": "NP_001171190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171190", "type": "external" } ], "gene_names_uniprotkb": "Madd; Kiaa0358", "gene_names_refseq": "9630059K23Rik; IG20; Madd; Rab3GEP; RabGEF", "protein_names_uniprotkb": "MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; Rab3GEP; RabGEF", "protein_names_refseq": "MAP kinase-activating death domain protein isoform 10; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange protein; Rab3 GEP; insulinoma-glucagonoma protein 20; rab3 GDP/GTP exchange factor", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:228355); (R-MMU-5357905); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11359932;12388783;15345747;16452087;18559336;18849981;20173027;21183079;21750661;22645316;24379354;33300544;34428180;40885482", "class_list": "", "function": "Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:11359932, PubMed:18559336). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (PubMed:11359932, PubMed:12388783, PubMed:18849981). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (PubMed:12388783). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (PubMed:18849981). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture, [RefSeq, PubMed]; These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin release from beta-cells and that its functional disruption can cause type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQK3;Q6P4I6;Q80W52;Q80WL3;Q80WL4;Q80WL5;Q80WL6;Q80WL7;Q80WL8;Q80WL9;Q80WM0;Q80WM1;Q80WM2;Q8CBC1", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0060125 negative regulation of growth hormone secretion;GO:0043410 positive regulation of MAPK cascade;GO:0097194 execution phase of apoptosis;GO:2001236 regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q80U28-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LC3-1", "uniprot_id": [ { "id": "NDUAA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LC3", "type": "external" } ], "mass": 40603.0, "length": 355, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "Ndufa10", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077159", "type": "external" } ], "gene_names_uniprotkb": "Ndufa10", "gene_names_refseq": "2900053E13Rik; Ndufa10", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; CI-42kD; Complex I-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit", "protein_names_refseq": "CI-42kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; complex I-42kD", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 22 (Disease Ontology:DOID:0112069)", "pathway": " (mmu:67273); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "21750661;23576753;23806337;24652937;31219806;33300544;34428180;36288343;37453647;37507081;37828378;38575788;38671439;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, PubMed]; CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKK0;Q8BL57;Q9CW21", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99LC3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC69-1", "uniprot_id": [ { "id": "NDUA9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC69", "type": "external" } ], "mass": 42525.0, "length": 377, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "gene_name": "Ndufa9", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079634", "type": "external" } ], "gene_names_uniprotkb": "Ndufa9", "gene_names_refseq": "1010001N11Rik; Ndufa9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; CI-39kD; Complex I-39kD; NADH-ubiquinone oxidoreductase 39 kDa subunit", "protein_names_refseq": "CI-39kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; NADH-ubiquinone oxidoreductase 39 kDa subunit; complex I-39kD", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 26 (Disease Ontology:DOID:0112086)", "pathway": " (mmu:66108); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19004814;21750661;23576753;23806337;30084848;31219806;31536960;33300544;34428180;36288343;37453647;38575788;38657899;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB]; NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTD3;Q99JP9", "ec_number_list": [], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006744 ubiquinone biosynthetic process;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9DC69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97432-1", "uniprot_id": [ { "id": "NBR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97432", "type": "external" } ], "mass": 109958.0, "length": 988, "protein_name": "Next to BRCA1 gene 1 protein", "gene_name": "Nbr1", "organism": "Mouse", "refseq_name": "next to BRCA1 gene 1 protein isoform 1", "refseq_ac": [ { "id": "NP_001239149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239149", "type": "external" } ], "gene_names_uniprotkb": "Nbr1; M17s2", "gene_names_refseq": "Nbr1; mKIAA0049", "protein_names_uniprotkb": "Next to BRCA1 gene 1 protein; Membrane component chromosome 17 surface marker 2 homolog; Neighbor of BRCA1 gene 1 protein", "protein_names_refseq": "membrane component chromosome 17 surface marker 2 homolog; neighbor of BRCA1 gene 1 protein; next to BRCA1 gene 1 protein isoform 1; next to BRCA1 gene 1 protein; next to the Brca1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17966); (R-MMU-9664873)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11179671;21750661;26495903;31916398;34001883;34374750;34428180;35820727;35984892;37620146;37828378;8975707", "class_list": "", "function": "NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARgamma. Publication Status: Online-Only, [RefSeq, PubMed]; Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation., [RefSeq, PubMed]; P62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (PubMed:31916398). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIH9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051019 mitogen-activated protein kinase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0030500 regulation of bone mineralization;GO:0045668 negative regulation of osteoblast differentiation;GO:0032872 regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97432-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZQ1-1", "uniprot_id": [ { "id": "MYORG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZQ1", "type": "external" } ], "mass": 81362.0, "length": 716, "protein_name": "Alpha-galactosidase MYORG", "gene_name": "Myorg", "organism": "Mouse", "refseq_name": "alpha-galactosidase MYORG", "refseq_ac": [ { "id": "NP_001078984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078984", "type": "external" } ], "gene_names_uniprotkb": "Myorg; AI464131; Kiaa1161; Net37", "gene_names_refseq": "Gm762; Kiaa1161; Myorg; NET37", "protein_names_uniprotkb": "Alpha-galactosidase MYORG; 3.2.1.22; Myogenesis regulating glycosidase; Nuclear envelope transmembrane protein 37", "protein_names_refseq": "alpha-galactosidase MYORG; full=Nuclear envelope transmembrane protein 37; myogenesis-regulating glycosidase; nuclear envelope transmembrane protein 37", "tax_id": 10090, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (mmu:329828)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17062158;19349973;19706595;21750661;29910000;30084848;30899004;34428180;37828378", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-galactosidase with unusual specificity for the Gal-alpha1,4-Glc structure, whose in vivo substrate is still unknown (By similarity). Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (PubMed:19706595)., [UniProtKB, PubMed, UniProtKB]; In mice, Myorg mRNA was expressed specifically in S100beta-positive astrocytes, and knockout of Myorg induced the formation of brain calcification at 9 months of age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2ANN6;B2RU42", "ec_number_list": [], "go_molecular_function": "GO:0004557 alpha-galactosidase activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0005975 carbohydrate metabolic process;GO:0048741 skeletal muscle fiber development;GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q69ZQ1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3I4-1", "uniprot_id": [ { "id": "MYRIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3I4", "type": "external" } ], "mass": 94924.0, "length": 856, "protein_name": "Rab effector MyRIP", "gene_name": "Myrip", "organism": "Mouse", "refseq_name": "rab effector MyRIP", "refseq_ac": [ { "id": "NP_653140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653140", "type": "external" } ], "gene_names_uniprotkb": "Myrip; Slac2c", "gene_names_refseq": "A230081N12Rik; Myrip; Slac2-c; Slac2c", "protein_names_uniprotkb": "Rab effector MyRIP; Exophilin-8; Myosin-VIIa- and Rab-interacting protein; SlaC2-c; Slp homolog lacking C2 domains c; Synaptotagmin-like protein lacking C2 domains C", "protein_names_refseq": "exophilin 8; myosin-VIIa- and Rab-interacting protein; rab effector MyRIP; slp homolog lacking C2 domains c; synaptotagmin-like protein lacking C2 domains C", "tax_id": 10090, "disease": "", "pathway": " (mmu:245049); (R-MMU-9824585)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11964381;12062444;12221080;15927964;17827149;21183079;21750661;28673385", "class_list": "", "function": "Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2. Publication Status: Online-Only, [RefSeq, PubMed]; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release., [UniProtKB, PubMed]; Slac2-c acts as a functional myosin VIIa receptor and the Rab27A.Slac2-c x myosin VIIa tripartite protein complex regulates the transport of retinal melanosomes in pigment epithelium cells, [RefSeq, PubMed]; Synaptotagmin-like protein homologue lacking C2 domains-c) is a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin GeneRIF: Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L320;A1L321;Q8CFC0;Q8K4H5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0016324 apical plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032024 positive regulation of insulin secretion;GO:0030050 vesicle transport along actin filament", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3I4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35136-1", "uniprot_id": [ { "id": "NCAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35136", "type": "external" } ], "mass": 93204.0, "length": 837, "protein_name": "Neural cell adhesion molecule 2", "gene_name": "Ncam2", "organism": "Mouse", "refseq_name": "neural cell adhesion molecule 2 isoform a precursor", "refseq_ac": [ { "id": "NP_001106679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106679", "type": "external" } ], "gene_names_uniprotkb": "Ncam2; Ocam; Rncam", "gene_names_refseq": "Ncam-2; Ncam2; Ocam; RNCAM", "protein_names_uniprotkb": "Neural cell adhesion molecule 2; N-CAM-2; NCAM-2; Neural cell adhesion molecule RB-8; R4B12", "protein_names_refseq": "R4B12 antigen; neural cell adhesion molecule 2 isoform a precursor; neural cell adhesion molecule RB-8; olfactory axon cell adhesion molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:17968)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;30899004;33300544;34428180;36251052;37522285;37724425;9221781;9334170", "class_list": "glycogene", "function": "Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits., [RefSeq, PubMed]; May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons., [UniProtKB]; Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)., [RefSeq, PubMed]; The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O35962;Q0VF23", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0016604 nuclear body;GO:0043005 neuron projection;GO:0097060 synaptic membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "O35136-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04247-1", "uniprot_id": [ { "id": "MYG_MOUSE", "url": "https://www.uniprot.org/uniprot/P04247", "type": "external" } ], "mass": 17070.0, "length": 154, "protein_name": "Myoglobin", "gene_name": "Mb", "organism": "Mouse", "refseq_name": "myoglobin", "refseq_ac": [ { "id": "NP_001157519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157519", "type": "external" } ], "gene_names_uniprotkb": "Mb", "gene_names_refseq": "Mb", "protein_names_uniprotkb": "Myoglobin; 1.11.1.-; 1.7.-.-; Nitrite reductase MB; Pseudoperoxidase MB", "protein_names_refseq": "myoglobin; nitrite reductase MB; pseudoperoxidase MB", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); iron deficiency anemia (Disease Ontology:DOID:11758); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); acute kidney failure (Disease Ontology:DOID:3021); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); hyperthyroidism (Disease Ontology:DOID:7998); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (mmu:17189); (R-MMU-8981607)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10468637;11304494;15132981;21183079;21750661;34384891;36288343;37161046;37507081;3758071;37759463;39927985;4043406;8666923;9804424", "class_list": "", "function": "Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice. Publication Status: Online-Only, [RefSeq, PubMed]; Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:10468637, PubMed:11304494). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (By similarity). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:15132981)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004601 peroxidase activity;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016528 sarcoplasm", "go_biological_process": "GO:0043353 enucleate erythrocyte differentiation;GO:0002931 response to ischemia;GO:0003009 skeletal muscle contraction;GO:0007507 heart development;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04247-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHK1-1", "uniprot_id": [ { "id": "MYCT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHK1", "type": "external" } ], "mass": 69062.0, "length": 637, "protein_name": "Proton myo-inositol cotransporter", "gene_name": "Slc2a13", "organism": "Mouse", "refseq_name": "proton myo-inositol cotransporter", "refseq_ac": [ { "id": "NP_001028805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028805", "type": "external" } ], "gene_names_uniprotkb": "Slc2a13", "gene_names_refseq": "6530403A04; A630029G22Rik; Gm308; Slc2a13", "protein_names_uniprotkb": "Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; H(+)-myo-inositol symporter; Hmit; Solute carrier family 2 member 13", "protein_names_refseq": "h(+)-myo-inositol cotransporter; h(+)-myo-inositol symporter; hmit; proton myo-inositol cotransporter; solute carrier family 2 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:239606); (R-MMU-429593)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19607714;21183079;22564531;26094765;31219806", "class_list": "glycogene", "function": "Astrocytes obtained directly from the brain express HMIT and is expressed in neurons, [RefSeq, PubMed]; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers., [UniProtKB, UniProtKB]; Inositol transport and homeostasis were unaffected in H+/myo-inositol transporter targeted null-mutant mice. Publication Status: Online-Only, [RefSeq, PubMed]; SLC2A13 is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch cleavage. Review article, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0051117 ATPase binding;GO:0005366 myo-inositol:proton symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0055085 transmembrane transport;GO:1902004 positive regulation of amyloid-beta formation;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UHK1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SV80-1", "uniprot_id": [ { "id": "MYO19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SV80", "type": "external" } ], "mass": 108075.0, "length": 963, "protein_name": "Unconventional myosin-XIX", "gene_name": "Myo19", "organism": "Mouse", "refseq_name": "unconventional myosin-XIX isoform 1", "refseq_ac": [ { "id": "NP_079690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079690", "type": "external" } ], "gene_names_uniprotkb": "Myo19; Myohd1", "gene_names_refseq": "1110055A02Rik; Myo19; Myohd1", "protein_names_uniprotkb": "Unconventional myosin-XIX; Myosin head domain-containing protein 1", "protein_names_refseq": "myosin head domain containing 1; myosin head domain-containing protein 1; unconventional myosin-XIX isoform 1; unconventional myosin-XIX", "tax_id": 10090, "disease": "", "pathway": " (mmu:66196); (R-MMU-9013419); (R-MMU-9013425)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24825904;31219806;34428180", "class_list": "", "function": "Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:24825904). Motor protein that moves towards the plus-end of actin filaments (PubMed:24825904). Required for mitochondrial inheritance during mitosis (By similarity). May be involved in mitochondrial transport or positioning (By similarity)., [UniProtKB, UniProtKB, PubMed]; Myo19 is a high-duty ratio molecular motor moving to the plus-end of the actin filament., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH54;Q9D2Z3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0034642 mitochondrion migration along actin filament;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SV80-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPH6-1", "uniprot_id": [ { "id": "MYCB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPH6", "type": "external" } ], "mass": 521232.0, "length": 4749, "protein_name": "E3 ubiquitin-protein ligase MYCBP2", "gene_name": "Mycbp2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MYCBP2", "refseq_ac": [ { "id": "NP_997098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997098", "type": "external" } ], "gene_names_uniprotkb": "Mycbp2; Pam; Phr1", "gene_names_refseq": "C130061D10Rik; Mycbp2; Pam; Phr1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MYCBP2; 2.3.2.33; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein Magellan; Protein associated with Myc", "protein_names_refseq": "E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; RING-type E3 ubiquitin transferase MYCBP2; pam, highwire, rpm 1; pam/highwire/rpm-1 protein; probable E3 ubiquitin-protein ligase MYCBP2; protein Magellan; protein associated with Myc", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); thyroid gland carcinoma (Disease Ontology:DOID:3963); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:105689)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12522145;14729956;17114649;17242355;17901218;18031680;19371781;19398581;20156452;20534529;21098484;21183079;21324225;21750661;23525682;23665224;25428506;26304119;29067676;30084848;31219806;31599954;34203471;34418053;34428180;36852467;40021952", "class_list": "", "function": "Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (By similarity). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (PubMed:14729956, PubMed:17901218, PubMed:18031680). Required for the formation of major central nervous system axon tracts (PubMed:17901218, PubMed:18031680). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (PubMed:18031680). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (PubMed:19371781, PubMed:21324225). Regulates axon guidance in the olfactory system (PubMed:23525682). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (PubMed:23665224). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (By similarity). Regulates the internalization of TRPV1 in peripheral sensory neurons (PubMed:21098484). May mediate ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (By similarity). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (By similarity). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquitination and degradation of NR1D1 (PubMed:20534529)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This study shows that Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9PUJ6;Q6PCM8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:0050905 neuromuscular process;GO:0032880 regulation of protein localization;GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q7TPH6-1", "record_type": "protein", "filter_code": "0000000.1100111.000100.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXR5-1", "uniprot_id": [ { "id": "NALCN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXR5", "type": "external" } ], "mass": 200441.0, "length": 1738, "protein_name": "Sodium leak channel NALCN", "gene_name": "Nalcn", "organism": "Mouse", "refseq_name": "sodium leak channel NALCN", "refseq_ac": [ { "id": "NP_796367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796367", "type": "external" } ], "gene_names_uniprotkb": "Nalcn; Vgcnl1", "gene_names_refseq": "A530023G15Rik; Nalcn; Vgcnl1", "protein_names_uniprotkb": "Sodium leak channel NALCN; Sodium leak channel non-selective protein; Voltage gated channel-like protein 1", "protein_names_refseq": "sodium leak channel NALCN; sodium leak channel non-selective protein; voltage gated channel like 1; voltage gated channel-like protein 1", "tax_id": 10090, "disease": "congenital limbs-face contractures-hypotonia-developmental delay syndrome (Disease Ontology:DOID:0081048)", "pathway": " (mmu:338370); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17448995;19092807;19575010;21040849;21099296;21177381;21750661;22508057;27177420;37640554;38197879", "class_list": "", "function": "Contributions of the Sodium Leak Channel NALCN to Pacemaking of Medial Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons., [RefSeq, PubMed]; Findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel, [RefSeq, PubMed]; NALCN ion channel is a new actor in pancreatic beta-cell physiology. Review article, [RefSeq, PubMed]; The Na[+] leak channel NALCN controls spontaneous activity and mediates synaptic modulation by alpha2-adrenergic receptors in auditory neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-unc-80 homolog (C. elegans) protein-non-selective protein voltage gated channel like 1 complex in a G protein-dependent fashion, [RefSeq, PubMed]; Unlike any of the other 20 family members, NALCN forms a voltage-independent, nonselective cation channel; NALCN mutant mice have a severely disrupted respiratory rhythm and die within 24 hours of birth., [RefSeq, PubMed]; Voltage-sensing, pore-forming subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (By similarity). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (PubMed:21177381, PubMed:22508057). Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (PubMed:27177420). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (PubMed:19092807). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (PubMed:19092807, PubMed:19575010, PubMed:21040849)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYM2", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0022840 leak channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0035725 sodium ion transmembrane transport;GO:0070588 calcium ion transmembrane transport;GO:0060075 regulation of resting membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BXR5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C854-4", "uniprot_id": [ { "id": "MYEF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C854", "type": "external" } ], "mass": 63295.0, "length": 591, "protein_name": "Myelin expression factor 2", "gene_name": "Myef2", "organism": "Mouse", "refseq_name": "myelin expression factor 2 isoform 1", "refseq_ac": [ { "id": "NP_001155889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155889", "type": "external" } ], "gene_names_uniprotkb": "Myef2; Kiaa1341; Mef2", "gene_names_refseq": "9430071B01; Myef2; mKIAA1341", "protein_names_uniprotkb": "Myelin expression factor 2; MEF-2; MyEF-2", "protein_names_refseq": "MEF-2; myEF-2; myelin expression factor 2 isoform 1; myelin expression factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17876)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11471062;22801375;24129315;25428506;26495903;31599954;34428180;35820727;7534248;7539003;9282330", "class_list": "", "function": "RUNX1 interacts with two novel protein partners, LSD1 and MYEF2, in erythroid cells., [RefSeq, PubMed]; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60690;Q6P930;Q6ZPT3;Q8QZZ1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C854-4", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R411-1", "uniprot_id": [ { "id": "MYCT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R411", "type": "external" } ], "mass": 21079.0, "length": 188, "protein_name": "Myc target protein 1", "gene_name": "Myct1", "organism": "Mouse", "refseq_name": "myc target protein 1", "refseq_ac": [ { "id": "NP_081069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081069", "type": "external" } ], "gene_names_uniprotkb": "Myct1; Mtmc1", "gene_names_refseq": "1110020B04Rik; Mtmc1; Myct1", "protein_names_uniprotkb": "Myc target protein 1; Myc target in myeloid cells protein 1", "protein_names_refseq": "myc target in myeloid cells protein 1; myc target protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68632)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11909865;16365299;17242355;21183079;34428180", "class_list": "", "function": "May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability and inhibition of hematopoietic differentiation., [UniProtKB, PubMed]; The properties imparted by MT-MC1 are the result of its control of a small and select c-Myc target gene population, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ11;Q8C6M8;Q9D182", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MZ6-1", "uniprot_id": [ { "id": "MYO7B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MZ6", "type": "external" } ], "mass": 240859.0, "length": 2113, "protein_name": "Unconventional myosin-VIIb", "gene_name": "Myo7b", "organism": "Mouse", "refseq_name": "unconventional myosin-VIIb", "refseq_ac": [ { "id": "NP_115770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115770", "type": "external" } ], "gene_names_uniprotkb": "Myo7b", "gene_names_refseq": "Myo7b", "protein_names_uniprotkb": "Unconventional myosin-VIIb", "protein_names_refseq": "myosin-VIIb; unconventional myosin-VIIb", "tax_id": 10090, "disease": "", "pathway": " (mmu:17922)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11401444;16186105;21183079;24725409;26812017;30084848;31219806;32209652;34418053", "class_list": "", "function": "Cloned, expressed and purified the catalytic motor domain, and characterized its actin-activated ATPase cycle, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EHR5;Q571N7;Q8R0U3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0005902 microvillus", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030154 cell differentiation;GO:0030048 actin filament-based movement;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99MZ6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIF9-1", "uniprot_id": [ { "id": "MYOTI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIF9", "type": "external" } ], "mass": 55316.0, "length": 496, "protein_name": "Myotilin", "gene_name": "Myot", "organism": "Mouse", "refseq_name": "myotilin", "refseq_ac": [ { "id": "NP_001028793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028793", "type": "external" } ], "gene_names_uniprotkb": "Myot; Myo; Ttid", "gene_names_refseq": "5530402I04Rik; Myot; Ttid", "protein_names_uniprotkb": "Myotilin; Myofibrillar titin-like Ig domains protein; Titin immunoglobulin domain protein", "protein_names_refseq": "myofibrillar titin-like Ig domains protein; myotilin; titin immunoglobulin domain protein", "tax_id": 10090, "disease": "myofibrillar myopathy 3 (Disease Ontology:DOID:0080094); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:58916)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11335118;15752755;17074808;19878039;24129315;39927985", "class_list": "", "function": "Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells (By similarity)., [UniProtKB]; Either myotilin does not participate in muscle development and basal function maintenance or other proteins serve as structural and functional compensatory molecules when myotilin is absent, [RefSeq, PubMed]; Features suggest an important role for myotilin in sarcomere organization., [RefSeq, PubMed]; Myotilin does not have a significant influence on muscle mass, muscle fiber size, or regulation of muscle contraction. Alternatively, compensatory over-expressions of other elements may compensate for the lack of myotilin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051393 alpha-actinin binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030424 axon;GO:0042383 sarcolemma;GO:0030018 Z disc", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JIF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK37-1", "uniprot_id": [ { "id": "MYOZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK37", "type": "external" } ], "mass": 31457.0, "length": 296, "protein_name": "Myozenin-1", "gene_name": "Myoz1", "organism": "Mouse", "refseq_name": "myozenin-1", "refseq_ac": [ { "id": "NP_067483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067483", "type": "external" } ], "gene_names_uniprotkb": "Myoz1", "gene_names_refseq": "2310001N11Rik; FATZ; Myoz1; Myoz", "protein_names_uniprotkb": "Myozenin-1; Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; Protein FATZ", "protein_names_refseq": "calcineurin-2; calsarcin-2; filamin-, actinin- and telethonin-binding protein; myozenin-1; skeletal muscle-specific protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:59011)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10984498;11114196;17341303;21183079;28002607;39927985", "class_list": "", "function": "Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis., [UniProtKB, PubMed, PubMed]; Results provide insights into the potential functions of miR-432 as well as its proposed target, MYOZ1, during muscle development. Publication Status: Online-Only, [RefSeq, PubMed]; Study defined proximal promoter region of calsarcin-1 (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required for transcription of CS-1 gene, but not CS-2 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9L3;Q9D7N4", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0030018 Z disc;GO:0031143 pseudopodium", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043503 skeletal muscle fiber adaptation;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0045214 sarcomere organization;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JK37-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "S4R2P9-1", "uniprot_id": [ { "id": "NAC3_MOUSE", "url": "https://www.uniprot.org/uniprot/S4R2P9", "type": "external" } ], "mass": 102984.0, "length": 928, "protein_name": "Sodium/calcium exchanger 3", "gene_name": "Slc8a3", "organism": "Mouse", "refseq_name": "sodium/calcium exchanger 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001161392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161392", "type": "external" } ], "gene_names_uniprotkb": "Slc8a3; Ncx3", "gene_names_refseq": "Ncx3; Slc8a3", "protein_names_uniprotkb": "Sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 3; sodium/calcium exchanger 3 isoform 1 precursor; sodium/calcium exchanger 3; solute carrier family 8 member 3", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:110893); (R-MMU-418359); (R-MMU-425561); (R-MMU-5578775)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "14722618;21593315;21750661;21959935;22806131;23506867;24101730;24616101;31599954;34203471;34360942;35087161;35705078;38859730", "class_list": "", "function": "Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; NCX3 plays an important role in vivo in the control of Ca(2+) concentrations in the skeletal muscle fibers and at the neuromuscular junction, [RefSeq, PubMed]; Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-alpha-Synuclein Transgenic Old Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-calcium exchanger-3 regulates pain ''wind-up'': From human psychophysics to spinal mechanisms., [RefSeq, PubMed]; The Na[+]/Ca[2+] exchanger NCX3 mediates Ca[2+] entry into matrix vesicles to facilitate initial steps of mineralization in osteoblasts., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS90;Q8VHJ8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0015368 calcium:monoatomic cation antiporter activity;GO:1905060 calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005741 mitochondrial outer membrane;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "S4R2P9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97460-1", "uniprot_id": [ { "id": "NPAS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97460", "type": "external" } ], "mass": 90916.0, "length": 816, "protein_name": "Neuronal PAS domain-containing protein 2", "gene_name": "Npas2", "organism": "Mouse", "refseq_name": "neuronal PAS domain-containing protein 2", "refseq_ac": [ { "id": "NP_032745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032745", "type": "external" } ], "gene_names_uniprotkb": "Npas2", "gene_names_refseq": "MOP4; Npas2; bHLHe9", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 2; Neuronal PAS2", "protein_names_refseq": "neuronal PAS domain-containing protein 2; neuronal PAS2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18143)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "12843397;14645221;15797872;16628007;16636276;17417633;18230344;18316400;18439826;19147932;20026146;21750661;22245004;23831463;24048828;24067359;25212631;29163035;30084848;33109704;34428180;35915264;36379250;36450499;40885482;9012850", "class_list": "", "function": "A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice., [RefSeq, PubMed]; Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver., [RefSeq, PubMed]; Involvement of Npas2 and Per2 modifications in zinc-induced acute diurnal toxicity in mice., [RefSeq, PubMed]; Results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal light:dark cycle and feeding conditions and that NPAS2 is critical for adaptability to food restriction, [RefSeq, PubMed]; The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. The encoded protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Dec 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (PubMed:25212631). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (PubMed:29163035)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051775 response to redox state;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P97460-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571H0-1", "uniprot_id": [ { "id": "NPA1P_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571H0", "type": "external" } ], "mass": 254614.0, "length": 2274, "protein_name": "Nucleolar pre-ribosomal-associated protein 1", "gene_name": "Urb1", "organism": "Mouse", "refseq_name": "nucleolar pre-ribosomal-associated protein 1", "refseq_ac": [ { "id": "NP_083773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083773", "type": "external" } ], "gene_names_uniprotkb": "Urb1; Kiaa0539; Npa1", "gene_names_refseq": "4921511H13Rik; 5730405K23Rik; Urb1; mKIAA0539", "protein_names_uniprotkb": "Nucleolar pre-ribosomal-associated protein 1; URB1 ribosome biogenesis 1 homolog", "protein_names_refseq": "nucleolar pre-ribosomal-associated protein 1; nucleolar preribosomal-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:207932)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20173027;21183079;21750661;22872234;31219806;34428180;36852467;36890225;37828378", "class_list": "", "function": "Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYN4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q571H0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF6-1", "uniprot_id": [ { "id": "NECT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKF6", "type": "external" } ], "mass": 57035.0, "length": 515, "protein_name": "Nectin-1", "gene_name": "Nectin1", "organism": "Mouse", "refseq_name": "nectin-1 precursor", "refseq_ac": [ { "id": "NP_067399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067399", "type": "external" } ], "gene_names_uniprotkb": "Nectin1; Hvec; Prr1; Pvrl1", "gene_names_refseq": "Cd111; HIgR; HveC; Nectin1; PRR1; PRR; Pvrl1; nectin-1", "protein_names_uniprotkb": "Nectin-1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Nectin cell adhesion molecule 1; Poliovirus receptor-related protein 1", "protein_names_refseq": "herpes virus entry mediator C; herpesvirus entry mediator C; nectin-1 alpha; nectin-1 delta; nectin-1 precursor; poliovirus receptor-related protein 1", "tax_id": 10090, "disease": "cleft lip-palate-ectodermal dysplasia syndrome (Disease Ontology:DOID:0060773); ectodermal dysplasia (Disease Ontology:DOID:2121); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:58235); (R-MMU-418990); (R-MMU-420597)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10744716;10781093;11090177;11827984;15328010;15345747;15728677;17242355;18703497;19144319;19349973;19656770;21183079;21750661;21798896;22645316;22955284;30899004;31219806;33300544;34203471;34428180;38030279", "class_list": "", "function": "(Microbial infection) Acts as a receptor for pseudorabies virus/PRV., [UniProtKB, PubMed]; Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:11827984, PubMed:15328010, PubMed:18703497, PubMed:21798896, PubMed:22955284). Acts by forming homophilic or heterophilic trans-dimers (PubMed:11827984). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (PubMed:11827984, PubMed:21798896). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed:15328010). Involved in synaptogegesis (PubMed:11827984). Has some neurite outgrowth-promoting activity (PubMed:22955284). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed:21798896). Required for enamel mineralization (PubMed:18703497)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9M9;Q9ERL5;Q9JI17", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0060041 retina development in camera-type eye;GO:0046718 symbiont entry into host cell;GO:0051963 regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q9JKF6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61937-1", "uniprot_id": [ { "id": "NPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61937", "type": "external" } ], "mass": 32560.0, "length": 292, "protein_name": "Nucleophosmin", "gene_name": "Npm1", "organism": "Mouse", "refseq_name": "nucleophosmin isoform 1", "refseq_ac": [ { "id": "NP_032748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032748", "type": "external" } ], "gene_names_uniprotkb": "Npm1", "gene_names_refseq": "B23; NO38; Npm1; Npm", "protein_names_uniprotkb": "Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin", "protein_names_refseq": "nucleolar phosphoprotein B23; nucleolar protein NO38; nucleophosmin isoform 1; numatrin", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary ovarian insufficiency (Disease Ontology:DOID:5426); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:18148); (R-MMU-3899300); (R-MMU-606279); (R-MMU-6804115); (R-MMU-8869496); (R-MMU-9833482)", "pathway_count": 6, "publication_count": 36, "publication_id_list": "11278991;12882984;16452087;17242355;18630941;19131326;19144319;19933706;20513429;21183079;21750661;22645316;23806337;24788674;24991885;25428506;28528544;30779550;31219806;31361958;31599954;3219912;32848054;33300544;33649389;33725478;34428180;35820727;35984892;36288343;36852467;37453647;37507081;39627609;40885482;9642267", "class_list": "", "function": "Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (PubMed:20513429)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:2000767 positive regulation of cytoplasmic translation;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q61937-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KCD5-1", "uniprot_id": [ { "id": "NIPBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6KCD5", "type": "external" } ], "mass": 315450.0, "length": 2798, "protein_name": "Nipped-B-like protein", "gene_name": "Nipbl", "organism": "Mouse", "refseq_name": "nipped-B-like protein isoform a", "refseq_ac": [ { "id": "NP_081983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081983", "type": "external" } ], "gene_names_uniprotkb": "Nipbl; Scc2", "gene_names_refseq": "Idn3; Nipbl", "protein_names_uniprotkb": "Nipped-B-like protein; Delangin homolog; SCC2 homolog", "protein_names_refseq": "Nipped-B homolog; SCC2 homolog; delangin homolog; nipped-B-like protein isoform a; nipped-B-like protein", "tax_id": 10090, "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:71175); (R-MMU-2470946)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;15146185;15146186;17242355;19144319;19763162;20485683;21183079;22645316;23806337;23967866;24129315;24287868;25428506;28041881;29094699;29379197;30779550;31219806;34428180;34678516;36210013;36852467;37958548;38507484;39742660", "class_list": "", "function": "Gastrulation-stage gene expression in Nipbl[+/-] mouse embryos foreshadows the development of syndromic birth defects., [RefSeq, PubMed]; Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of Cornelia de Lange Syndrome., [RefSeq, PubMed]; Nipbl Haploinsufficiency Leads to Delayed Outflow Tract Septation and Aortic Valve Thickening. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the loading of the cohesin complex on to DNA (PubMed:29094699). Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6KC78;Q7TNS4;Q8BKV4;Q8CES9;Q9CUC6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0070087 chromo shadow domain binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0032039 integrator complex", "go_biological_process": "GO:0061010 gallbladder development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q6KCD5-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14BI7-1", "uniprot_id": [ { "id": "TDRD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14BI7", "type": "external" } ], "mass": 155980.0, "length": 1383, "protein_name": "ATP-dependent RNA helicase TDRD9", "gene_name": "Tdrd9", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase TDRD9", "refseq_ac": [ { "id": "NP_083332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083332", "type": "external" } ], "gene_names_uniprotkb": "Tdrd9", "gene_names_refseq": "4930441E05Rik; Tdrd9", "protein_names_uniprotkb": "ATP-dependent RNA helicase TDRD9; 3.6.4.13; Tudor domain-containing protein 9", "protein_names_refseq": "ATP-dependent RNA helicase TDRD9; putative ATP-dependent RNA helicase TDRD9; tudor domain-containing protein 9", "tax_id": 10090, "disease": "spermatogenic failure 30 (Disease Ontology:DOID:0111913)", "pathway": " (mmu:74691)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17660561;19584108;20011505;20059948;21750661;28633017;30031227;31219806;35820727", "class_list": "", "function": "ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017). Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4 (PubMed:28633017)., [UniProtKB, PubMed, PubMed]; ATPase activity of TDRD9 is dispensable for piRNA biogenesis but is essential for transposon silencing and male fertility, [RefSeq, PubMed]; Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1Q3J8;Q14AW6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.1.1.386", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071547 piP-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q14BI7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTX6-1", "uniprot_id": [ { "id": "CUL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTX6", "type": "external" } ], "mass": 89692.0, "length": 776, "protein_name": "Cullin-1", "gene_name": "Cul1", "organism": "Mouse", "refseq_name": "cullin-1", "refseq_ac": [ { "id": "NP_036172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036172", "type": "external" } ], "gene_names_uniprotkb": "Cul1", "gene_names_refseq": "Cul-1; Cul1", "protein_names_uniprotkb": "Cullin-1; CUL-1", "protein_names_refseq": "cullin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26965); (R-MMU-1169091); (R-MMU-1170546); (R-MMU-174113); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2565942); (R-MMU-2871837); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-68949); (R-MMU-69231); (R-MMU-69601); (R-MMU-8854050); (R-MMU-8939902); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-917937); (R-MMU-9708530); (R-MMU-9762114); (R-MMU-983168); (R-MMU-9929356)", "pathway_count": 27, "publication_count": 21, "publication_id_list": "10097128;10508527;11735228;11967155;12140560;16880526;20190741;21750661;23319590;23452855;23452856;24129315;25605945;31219806;33300544;34203471;34428180;36210013;37507081;39003567;9663463", "class_list": "", "function": "CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis., [RefSeq, PubMed]; Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Neddylated CUL1-RBX1 ubiquitinates p53/TP53 recruited by Cul7-RING(FBXW8) complex (By similarity). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (By similarity). The SCF(FBXO31) protein ligase complex specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUI7", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0008283 cell population proliferation;GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9WTX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2Y4-1", "uniprot_id": [ { "id": "MLKL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2Y4", "type": "external" } ], "mass": 54317.0, "length": 472, "protein_name": "Mixed lineage kinase domain-like protein", "gene_name": "Mlkl", "organism": "Mouse", "refseq_name": "mixed lineage kinase domain-like protein isoform 1", "refseq_ac": [ { "id": "NP_001297542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297542", "type": "external" } ], "gene_names_uniprotkb": "Mlkl", "gene_names_refseq": "9130019I15Rik; Mlkl", "protein_names_uniprotkb": "Mixed lineage kinase domain-like protein", "protein_names_refseq": "mixed lineage kinase domain-like protein isoform 1; mixed lineage kinase domain-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74568); (R-MMU-3295583); (R-MMU-5213460); (R-MMU-5675482)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "21750661;22265413;23612963;23835476;24012422;24019532;24095729;27321907;27819681;28807105;28892415;30059200;32200799;32296175;35820727", "class_list": "", "function": "Findings implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3., [RefSeq, PubMed]; Neither Mlkl nor Rip3 deficiency provided protection against polymicrobial sepsis-induced animal death in the study of septic shock induced by CLP., [RefSeq, PubMed]; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:23835476, PubMed:24012422, PubMed:24019532, PubMed:27321907, PubMed:32200799, PubMed:32296175). Does not have protein kinase activity (PubMed:24012422). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:23835476, PubMed:24012422, PubMed:24019532, PubMed:27321907). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799, PubMed:32296175). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The importance of the RIP3-MLKL interaction in the formation of functional necrosomes and suggest that translocation of necrosomes to mitochondria-associated membranes is essential for necroptosis signaling., [RefSeq, PubMed]; This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIJ5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0070207 protein homotrimerization;GO:0097527 necroptotic signaling pathway;GO:0070266 necroptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D2Y4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4I2-1", "uniprot_id": [ { "id": "MEII1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4I2", "type": "external" } ], "mass": 140874.0, "length": 1268, "protein_name": "Meiosis inhibitor protein 1", "gene_name": "Mei1", "organism": "Mouse", "refseq_name": "meiosis inhibitor protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001297364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297364", "type": "external" } ], "gene_names_uniprotkb": "Mei1", "gene_names_refseq": "4932408F18Rik; Mei1", "protein_names_uniprotkb": "Meiosis inhibitor protein 1; Meiosis defective protein 1", "protein_names_refseq": "meiosis defective protein 1; meiosis inhibitor protein 1 isoform 2; meiosis inhibitor protein 1", "tax_id": 10090, "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590)", "pathway": " (mmu:74369)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11820814;14668445;15928951;21750661;30388401;33300544", "class_list": "", "function": "Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis., [RefSeq, PubMed]; Mei1 is required for vertebrate meiosis., [RefSeq, PubMed]; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ44;F8WHB9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0048477 oogenesis;GO:0040038 polar body extrusion after meiotic divisions;GO:0045141 meiotic telomere clustering", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D4I2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RHR9-1", "uniprot_id": [ { "id": "MAGI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RHR9", "type": "external" } ], "mass": 161974.0, "length": 1471, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "gene_name": "Magi1", "organism": "Mouse", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c", "refseq_ac": [ { "id": "NP_001025021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025021", "type": "external" } ], "gene_names_uniprotkb": "Magi1; Baiap1; Bap1", "gene_names_refseq": "AIP3; BAP1; Baiap1; Gukmi1; MAGI1c; Magi-1; Magi1; TNRC19; WWP3; mKIAA4129", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; BAI1-associated protein 1; BAP-1; MAGI-1; Membrane-associated guanylate kinase inverted 1", "protein_names_refseq": "BAI1-associated protein 1; membrane-associated guanylate kinase inverted 1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14924)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10772923;11274227;11350080;15304526;15317815;15383320;15509766;20485683;21183079;21750661;22517741;22645316;24806444;31219806;32848054;33712709;34428180;34678516;40021952;40885482;9395497", "class_list": "", "function": "MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (PubMed:24806444). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O54893;O54894;O54895", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007165 signal transduction;GO:0001886 endothelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6RHR9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDG8-1", "uniprot_id": [ { "id": "MON1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDG8", "type": "external" } ], "mass": 62131.0, "length": 556, "protein_name": "Vacuolar fusion protein MON1 homolog A", "gene_name": "Mon1a", "organism": "Mouse", "refseq_name": "vacuolar fusion protein MON1 homolog A", "refseq_ac": [ { "id": "NP_082645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082645", "type": "external" } ], "gene_names_uniprotkb": "Mon1a", "gene_names_refseq": "2810468K17Rik; Mon1a", "protein_names_uniprotkb": "Vacuolar fusion protein MON1 homolog A", "protein_names_refseq": "vacuolar fusion protein MON1 homolog A", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (mmu:72825); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17242355;17632513;19144319;20305638;21183079;21750661;22665492;24121729;34418053;34428180", "class_list": "", "function": "A role for Mon1a in anterograde trafficking through the secretory apparatus., [RefSeq, PubMed]; Data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses, [RefSeq, PubMed]; Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism., [RefSeq, PubMed]; Plays an important role in membrane trafficking through the secretory apparatus., [UniProtKB, UniProtKB, UniProtKB]; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (PubMed:17632513). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study presents evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80UP6;Q9CYS2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0035658 Mon1-Ccz1 complex", "go_biological_process": "GO:0015031 protein transport;GO:0006879 intracellular iron ion homeostasis;GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PDG8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62433-1", "uniprot_id": [ { "id": "NDRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62433", "type": "external" } ], "mass": 43009.0, "length": 394, "protein_name": "Protein NDRG1", "gene_name": "Ndrg1", "organism": "Mouse", "refseq_name": "protein NDRG1", "refseq_ac": [ { "id": "NP_032707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032707", "type": "external" } ], "gene_names_uniprotkb": "Ndrg1; Ndr1; Ndrl; Tdd5", "gene_names_refseq": "CAP43; CMT4D; DRG1; HMSNL; NMSL; Ndr1; Ndrg1; Ndrl; PROXY1; RTP; TDD5", "protein_names_uniprotkb": "Protein NDRG1; N-myc downstream-regulated gene 1 protein; Protein Ndr1", "protein_names_refseq": "N-myc downstream regulated 1; N-myc downstream-regulated gene 1 protein; protein NDRG1; protein Ndr1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4D (Disease Ontology:DOID:0110186)", "pathway": " (mmu:17988)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10381566;12804568;14729612;15082788;15461589;17242355;19144319;21183079;21303696;21636852;21655274;21750661;24265802;24687281;25428506;28135057;28528544;30084848;30779550;31219806;34428180;39444004;9144177", "class_list": "", "function": "May be a mast cell maturation-associated inducible protein that allows the cells to be susceptible to extracellular stimuli leading to degranulation, [RefSeq, PubMed]; NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Nickel induces HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway., [RefSeq, PubMed]; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97862", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0045296 cadherin binding;GO:0031267 small GTPase binding;GO:0016151 nickel cation binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0071456 cellular response to hypoxia;GO:0032287 peripheral nervous system myelin maintenance;GO:0030330 DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q62433-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60949-1", "uniprot_id": [ { "id": "TBCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60949", "type": "external" } ], "mass": 142026.0, "length": 1255, "protein_name": "TBC1 domain family member 1", "gene_name": "Tbc1d1", "organism": "Mouse", "refseq_name": "TBC1 domain family member 1 isoform 3", "refseq_ac": [ { "id": "NP_001297540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297540", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d1; Kiaa1108; Tbc1", "gene_names_refseq": "1110062G02Rik; Nob1; Nobq1; Tbc1d1; Tbc1; mKIAA1108", "protein_names_uniprotkb": "TBC1 domain family member 1", "protein_names_refseq": "TBC1 domain family member 1 isoform 3; tre-2/USP6, BUB2, cdc16) domain family, member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57915)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "19740738;20299473;20701589;21183079;21750661;23349504;23671593;24101676;26495903;27467141;27826658;30542240;30733181;31219806;34428180;34837397;7566974", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia-reperfusion injury via TAK1-JNK/p38 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLW9;Q80TJ9;Q923F8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60949-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK03-1", "uniprot_id": [ { "id": "MIGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK03", "type": "external" } ], "mass": 65548.0, "length": 593, "protein_name": "Mitoguardin 2", "gene_name": "Miga2", "organism": "Mouse", "refseq_name": "mitoguardin 2 isoform 1", "refseq_ac": [ { "id": "NP_001229336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229336", "type": "external" } ], "gene_names_uniprotkb": "Miga2; Fam73b", "gene_names_refseq": "5730472N09Rik; C9orf54; Fam73b; Miga2", "protein_names_uniprotkb": "Mitoguardin 2; Protein FAM73B", "protein_names_refseq": "mFLJ00199 protein; mitoguardin 2 isoform 1; ortholog of family with sequence similarity 73, member B FAM73B; protein FAM73B", "tax_id": 10090, "disease": "", "pathway": " (mmu:108958); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;26711011;26716412;34428180", "class_list": "", "function": "Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD., [RefSeq, PubMed]; Regulator of mitochondrial fusion (PubMed:26711011). Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6PX05;Q3U4J7;Q3UST7", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060348 bone development;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BK03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K337-1", "uniprot_id": [ { "id": "I5P2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K337", "type": "external" } ], "mass": 112762.0, "length": 993, "protein_name": "Type II inositol 1,4,5-trisphosphate 5-phosphatase", "gene_name": "Inpp5b", "organism": "Mouse", "refseq_name": "type II inositol 1,4,5-trisphosphate 5-phosphatase precursor", "refseq_ac": [ { "id": "NP_032411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032411", "type": "external" } ], "gene_names_uniprotkb": "Inpp5b", "gene_names_refseq": "5PTase; INPP5P; Inpp5b", "protein_names_uniprotkb": "Type II inositol 1,4,5-trisphosphate 5-phosphatase; 3.1.3.36; 3.1.3.56; 5-phosphatase II; 5PTase; Inositol polyphosphate-5-phosphatase B; Phosphoinositide 5-phosphatase", "protein_names_refseq": "5-phosphatase II; inositol polyphosphate-5-phosphatase, 75 kDa; phosphoinositide 5-phosphatase; type II inositol 1,4,5-trisphosphate 5-phosphatase precursor; type II inositol 1,4,5-trisphosphate 5-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:16330); (R-MMU-1855183); (R-MMU-1855204)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11311145;19536138;20872266;21750661;22072788;25869668;34428180;38927017;9525932", "class_list": "", "function": "CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events., [UniProtKB, PubMed, PubMed]; Study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl function, [RefSeq, PubMed]; This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54996;Q8CF65;Q91ZF8", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030670 phagocytic vesicle membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K337-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VL1-1", "uniprot_id": [ { "id": "TDRKH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VL1", "type": "external" } ], "mass": 62134.0, "length": 560, "protein_name": "Tudor and KH domain-containing protein", "gene_name": "Tdrkh", "organism": "Mouse", "refseq_name": "tudor and KH domain-containing protein isoform 1", "refseq_ac": [ { "id": "NP_082583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082583", "type": "external" } ], "gene_names_uniprotkb": "Tdrkh; Tdrd2", "gene_names_refseq": "2700091C21Rik; Tdrd2; Tdrkh", "protein_names_uniprotkb": "Tudor and KH domain-containing protein; Tudor domain-containing protein 2", "protein_names_refseq": "tudor and KH domain-containing protein isoform 1; tudor domain-containing protein 2", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:72634)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19584108;19918066;21750661;22645316;23714778;29118143;30590800", "class_list": "", "function": "Loss of Tdrkh is associated with impaired spermatogenesis., [RefSeq, PubMed]; Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1., [RefSeq, PubMed]; We show that mitochondria-anchored TDRKH controls multiple steps of pachytene piRNA biogenesis in mice. TDRKH specifically recruits MIWI, but not MILI, to engage the piRNA pathway. It is required for the production of the entire MIWI-bound piRNA population and enables trimming of MILI-bound piRNAs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0071546 pi-body;GO:0071547 piP-body", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80VL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UKC1-1", "uniprot_id": [ { "id": "TAXB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UKC1", "type": "external" } ], "mass": 93630.0, "length": 814, "protein_name": "Tax1-binding protein 1 homolog", "gene_name": "Tax1bp1", "organism": "Mouse", "refseq_name": "tax1-binding protein 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_080092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080092", "type": "external" } ], "gene_names_uniprotkb": "Tax1bp1", "gene_names_refseq": "1200003J11Rik; 1700069J21Rik; D6Ertd404e; D6Ertd772e; T6bp; TXBP151; Tax1bp1", "protein_names_uniprotkb": "Tax1-binding protein 1 homolog", "protein_names_refseq": "TRAF6-binding protein homolog; tax1-binding protein 1 homolog isoform 1; tax1-binding protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:52440); (R-MMU-5357905); (R-MMU-936440)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10435631;15509224;16075062;18239685;19144319;21183079;21750661;21765415;25605945;31219806;33207181;34225486;34428180;35470757;35984892;38065272", "class_list": "", "function": "Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages., [RefSeq, PubMed]; Multifaceted roles of TAX1BP1 in autophagy. Review article, [RefSeq, PubMed]; TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction., [RefSeq, PubMed]; Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:18239685, PubMed:33207181). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (By similarity). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:18239685). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (By similarity). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (By similarity). Mediates the autophagic degradation of other substrates including TICAM1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YT6;Q9CVF0;Q9DC45", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0019900 kinase binding;GO:0035591 signaling adaptor activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0000407 phagophore assembly site", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UKC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XB4-1", "uniprot_id": [ { "id": "NRAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XB4", "type": "external" } ], "mass": 195756.0, "length": 1728, "protein_name": "Nebulin-related-anchoring protein", "gene_name": "Nrap", "organism": "Mouse", "refseq_name": "nebulin-related-anchoring protein isoform 3", "refseq_ac": [ { "id": "NP_001273481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273481", "type": "external" } ], "gene_names_uniprotkb": "Nrap", "gene_names_refseq": "Nrap", "protein_names_uniprotkb": "Nebulin-related-anchoring protein; N-RAP", "protein_names_refseq": "N-RAP; nebulin-related-anchoring protein isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18175)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10320340;11732910;12692149;12789664;15765519;21183079;21750661;30986853;34428180;36288343;40021952;9295142", "class_list": "", "function": "Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy., [RefSeq, PubMed]; Highly conserved and exclusively expressed in cardiac and skeletal muscle. Candidate cause for cardiac and skeletal myopathies, [RefSeq, PubMed]; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QN76;O35884;Q3UTY7;Q3UU10;Q80V40", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0017166 vinculin binding", "go_cellular_component": "GO:0030018 Z disc;GO:0005916 fascia adherens;GO:0030016 myofibril;GO:0005927 muscle tendon junction", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0071691 cardiac muscle thin filament assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80XB4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYG0-1", "uniprot_id": [ { "id": "NDRG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYG0", "type": "external" } ], "mass": 40789.0, "length": 371, "protein_name": "Protein NDRG2", "gene_name": "Ndrg2", "organism": "Mouse", "refseq_name": "protein NDRG2 isoform 2", "refseq_ac": [ { "id": "NP_001139431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139431", "type": "external" } ], "gene_names_uniprotkb": "Ndrg2; Kiaa1248; Ndr2", "gene_names_refseq": "Ndr2; Ndrg2; SYLD", "protein_names_uniprotkb": "Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Ndr2", "protein_names_refseq": "N-myc downstream regulated 2; N-myc downstream-regulated gene 2 protein; protein NDRG2 isoform 2; protein NDRG2; protein Ndr2", "tax_id": 10090, "disease": "", "pathway": " (mmu:29811)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10581191;14985363;15207261;15461589;16520977;17242355;18630941;20485683;21183079;21247902;21636852;21750661;30084848;34428180;36288343;36989575;37329577;37507081;38037211;39193856;39927985;40885482", "class_list": "", "function": "Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data identify Ndrg2 as a novel insulin-dependent phosphoprotein and suggest that PKC theta may inhibit insulin action in part by reducing its phosphorylation by Akt., [RefSeq, PubMed]; NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3/TIMP3/MMP pathway in mice with retinal degenerative disease., [RefSeq, PubMed]; NDRG2 regulates glucose metabolism and ferroptosis of OGD/R-treated astrocytes by the Wnt/beta-catenin signaling., [RefSeq, PubMed]; ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis., [RefSeq, PubMed]; Reprogramming astrocytic NDRG2/NF-kappaB/C3 signaling restores the diabetes-associated cognitive dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI48;Q3TY42;Q3U3T5;Q69ZN2;Q8C661", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9QYG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z204-1", "uniprot_id": [ { "id": "HNRPC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z204", "type": "external" } ], "mass": 34385.0, "length": 313, "protein_name": "Heterogeneous nuclear ribonucleoproteins C1/C2", "gene_name": "Hnrnpc", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2", "refseq_ac": [ { "id": "NP_001164452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164452", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpc; Hnrpc", "gene_names_refseq": "D14Wsu171e; Hnrnpc; Hnrpc1; Hnrpc2; Hnrpc; hnRNPC1; hnRNPC2; hnrnp-C", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein C1; heterogeneous nuclear ribonucleoprotein C2; heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2; heterogeneous nuclear ribonucleoproteins C1/C2; heterogeneous ribonucleoprotein C1/C2; hnRNP C1 / hnRNP C2; hnRNP C1/C2; snoRNA MBI-122", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 74 (Disease Ontology:DOID:0061047); atherosclerosis (Disease Ontology:DOID:1936); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:15381); (R-MMU-4570464); (R-MMU-72163); (R-MMU-72203); (R-MMU-9013418); (R-MMU-9013422); (R-MMU-9770562)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10805751;15345747;17242355;19144319;21183079;21750661;23806337;29846695;30084848;31219806;33725478;34428180;35729324;35820727;36681355;37453647;39627609", "class_list": "", "function": "Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HnRNPC induces isoform shifts in miR-21-5p leading to cancer development., [RefSeq, PubMed]; N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway., [RefSeq, PubMed]; The data show that hnRNPC1 may be involved in the internalization of miR-30d inside exosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLB5;Q501Q3;Q8C2G5;Q99KE2;Q9CQT3;Q9CY83", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0004857 enzyme inhibitor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0090367 negative regulation of mRNA modification", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9Z204-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99L90-1", "uniprot_id": [ { "id": "MCRS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99L90", "type": "external" } ], "mass": 51692.0, "length": 462, "protein_name": "Microspherule protein 1", "gene_name": "Mcrs1", "organism": "Mouse", "refseq_name": "microspherule protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001157628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157628", "type": "external" } ], "gene_names_uniprotkb": "Mcrs1; Msp58", "gene_names_refseq": "ICP22BP; MSP58; Mcrs1; P78", "protein_names_uniprotkb": "Microspherule protein 1; 58 kDa microspherule protein", "protein_names_refseq": "58 kDa microspherule protein; microspherule protein 1 isoform 2; nucleolar protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:51812); (R-MMU-3214847); (R-MMU-5689603); (R-MMU-5696394); (R-MMU-9772755)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "15345747;16479539;19144319;21183079;21750661;23806337;29187734;30059200;30084848;31219806;31671403;32152506;34203471;34428180;36210013;36951681;9654073", "class_list": "", "function": "Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis., [RefSeq, PubMed]; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity). May also be an inhibitor of TERT telomerase activity (By similarity). Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U) (By similarity). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (By similarity). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (By similarity). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (By similarity). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (By similarity). Regulates G2/M transition and spindle assembly during oocyte meiosis (PubMed:36951681). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (PubMed:36951681). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (PubMed:36951681). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (By similarity). Required for epiblast development during early embryogenesis (PubMed:31671403). Essential for cell viability (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35255;Q32P11", "ec_number_list": [], "go_molecular_function": "GO:0002151 G-quadruplex RNA binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding;GO:0010521 telomerase inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99L90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS57-1", "uniprot_id": [ { "id": "MABP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS57", "type": "external" } ], "mass": 162892.0, "length": 1503, "protein_name": "Mitogen-activated protein kinase-binding protein 1", "gene_name": "Mapkbp1", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_036071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036071", "type": "external" } ], "gene_names_uniprotkb": "Mapkbp1; Jnkbp1; Kiaa0596", "gene_names_refseq": "2810483F24Rik; JNKBP-1; Jnkbp1; Mapkbp1; mKIAA0596", "protein_names_uniprotkb": "Mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; JNKBP-1", "protein_names_refseq": "JNK-binding protein 1; Jun N-terminal kinase binding protein 1; mitogen-activated protein kinase-binding protein 1 isoform 2", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 2 with or without cortical malformations (Disease Ontology:DOID:0070293); nephronophthisis 20 (Disease Ontology:DOID:0111127); microcephaly (Disease Ontology:DOID:10907); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:26390)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10471813;19385034;21750661;25428506;28089251", "class_list": "", "function": "Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway (PubMed:10471813)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The Mapkbp1 protein could enhance the NF-kappaB activation induced by MAP kinase kinase kinase 7 and TNF Receptor-Associated Factor 2 , and could promote TNF Receptor-Associated Factor 2 polyubiquitination., [RefSeq, PubMed]; We identified mutations in MAPKBP1 as a genetic cause of juvenile or late-onset and cilia-independent nephronophthisis. Erratum:[Am J Hum Genet. 2017 Feb 2;100(2):372. doi: 10.1016/j.ajhg.2017.01.025. PMID: 28157543], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AWL8;Q80TW5;Q9R0L0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0097431 mitotic spindle pole;GO:0000922 spindle pole", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0032717 negative regulation of interleukin-8 production;GO:1900425 negative regulation of defense response to bacterium;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NS57-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A070-1", "uniprot_id": [ { "id": "TGRM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A070", "type": "external" } ], "mass": 194910.0, "length": 1776, "protein_name": "TOG array regulator of axonemal microtubules protein 1", "gene_name": "Togaram1", "organism": "Mouse", "refseq_name": "TOG array regulator of axonemal microtubules protein 1 isoform 2", "refseq_ac": [ { "id": "NP_808473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808473", "type": "external" } ], "gene_names_uniprotkb": "Togaram1; Fam179b; Kiaa0423", "gene_names_refseq": "A430041B07Rik; C130034K06; Fam179b; Togaram1", "protein_names_uniprotkb": "TOG array regulator of axonemal microtubules protein 1; Crescerin-1; Protein FAM179B", "protein_names_refseq": "TOG array regulator of axonemal microtubules protein 1 isoform 2; TOG array regulator of axonemal microtubules protein 1; crescerin-1; family with sequence similarity 179, member B; protein FAM179B", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (mmu:328108)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22872234;26378256;28063167;31219806;32747439;34203471;34428180", "class_list": "", "function": "Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (PubMed:26378256, PubMed:32747439)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This study reveals that the cell-specific loss of TOG in oligodendrocytes severely reduced myelination in the CNS., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F8WJB2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0005881 cytoplasmic microtubule;GO:0005856 cytoskeleton", "go_biological_process": "GO:0060271 cilium assembly;GO:0000226 microtubule cytoskeleton organization;GO:0031116 positive regulation of microtubule polymerization;GO:1905515 non-motile cilium assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6A070-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VII8-1", "uniprot_id": [ { "id": "MCR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VII8", "type": "external" } ], "mass": 106447.0, "length": 978, "protein_name": "Mineralocorticoid receptor", "gene_name": "Nr3c2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nr3c2; Mlr", "gene_names_refseq": "", "protein_names_uniprotkb": "Mineralocorticoid receptor; MR; Nuclear receptor subfamily 3 group C member 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060855); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); pseudohypoaldosteronism (Disease Ontology:DOID:4479); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-MMU-3371497); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11997477;17242355;19029984;21183079;21750661;34428180;40885482;40997131", "class_list": "", "function": "Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VII9", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VII8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VS7-1", "uniprot_id": [ { "id": "MGST1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VS7", "type": "external" } ], "mass": 17552.0, "length": 155, "protein_name": "Microsomal glutathione S-transferase 1", "gene_name": "Mgst1", "organism": "Mouse", "refseq_name": "microsomal glutathione S-transferase 1 isoform 1", "refseq_ac": [ { "id": "NP_064330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064330", "type": "external" } ], "gene_names_uniprotkb": "Mgst1", "gene_names_refseq": "1500002K10Rik; Gst; Mgst1", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 1; 2.5.1.18; Microsomal GST-1; Microsomal GST-I", "protein_names_refseq": "microsomal GST-1; microsomal GST-I; microsomal glutathione S-transferase 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56615); (R-MMU-156590); (R-MMU-5423646); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "15157743;15641772;19444856;21750661;23576753;25428506;26495903;27802388;28011936;29702404;31219806;31599954;34428180;35547804;37321450;37453647", "class_list": "", "function": "A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression., [RefSeq, PubMed]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Gst genes are extensively downregulated in primary but not metastatic TRAMP tumors., [RefSeq, PubMed]; Identification of the promoter region and a comprehensive examination of tissue expression of MGST1, [RefSeq, PubMed]; MGST1 is a dominant, highly expressed enzyme in mouse retinal pigment epithelium (RPE) microsomes that displays an important protective function against oxidative insult in the RPE that decreases with age., [RefSeq, PubMed]; The impact of MGST1 on hematopoiesis was also shown in hematopoietic stem/progenitor cells (HSPC) isolated from mice, where it was expressed at high levels. Upon promoting HSPC differentiation, lentiviral shRNA MGST1 knockdown significantly reduced differentiated, dedicated cells of the hematopoietic system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ57;Q9R191", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0034635 glutathione transport;GO:0032496 response to lipopolysaccharide;GO:0009410 response to xenobiotic stimulus;GO:0006749 glutathione metabolic process;GO:0071449 cellular response to lipid hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91VS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV30-1", "uniprot_id": [ { "id": "NFAT5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV30", "type": "external" } ], "mass": 165800.0, "length": 1534, "protein_name": "Nuclear factor of activated T-cells 5", "gene_name": "Nfat5", "organism": "Mouse", "refseq_name": "nuclear factor of activated T-cells 5 isoform c", "refseq_ac": [ { "id": "NP_001273189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273189", "type": "external" } ], "gene_names_uniprotkb": "Nfat5", "gene_names_refseq": "B130038B15Rik; CAG-8; CAG80; NFATL1; Nfat5; OREBP; TonEBP; mKIAA0827; nfatz", "protein_names_uniprotkb": "Nuclear factor of activated T-cells 5; NF-AT5; Rel domain-containing transcription factor NFAT5; T-cell transcription factor NFAT5", "protein_names_refseq": "T-cell transcription factor NFAT5; nuclear factor of activated T-cells 5 isoform c; rel domain-containing transcription factor NFAT5; tonicity-responsive enhancer binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:54446)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10377394;11233530;11780147;11934689;14983020;21750661;23233732;23806337;31219806;34428180;35822049;38381247;38421307;38426494;40885482;40997131", "class_list": "", "function": "A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc., [RefSeq, PubMed]; SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and Oxidative Stress in Parkinson's Disease., [RefSeq, PubMed]; Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the NFAT5/TonEBP DNA binding domain bound to a TonE DNA element. The structure shows DNA encirclement by two dimerization interfaces: (1) at the TIG domain similar to NF-kappaB family members, and (2) at the DNA recognition domain., [RefSeq, PubMed]; Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:11934689, PubMed:14983020). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (By similarity). Mediates the transcriptional response to hypertonicity (By similarity). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (By similarity). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0P3;E9Q6U2;G5E8N9;Q91WY0;Q9JLA1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0003091 renal water homeostasis;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9WV30-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01237-1", "uniprot_id": [ { "id": "HMDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01237", "type": "external" } ], "mass": 97040.0, "length": 887, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "gene_name": "Hmgcr", "organism": "Mouse", "refseq_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1", "refseq_ac": [ { "id": "NP_032281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032281", "type": "external" } ], "gene_names_uniprotkb": "Hmgcr", "gene_names_refseq": "HMG-CoAR; Hmgcr; Red", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase; 1.1.1.34; HMG-CoA reductase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1; HMG-CoA reductase", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:15357); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12920113;16100574;19224205;20173027;21183079;21750661;2258621;22872234;25428506;30084848;30619997;30779550;31219806;34203471;34428180;35820727;38641905", "class_list": "", "function": "Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial beta-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X8U5;Q5U4I2", "ec_number_list": [ { "id": "1.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0042802 identical protein binding;GO:0051721 protein phosphatase 2A binding;GO:0030695 GTPase regulator activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q01237-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URK3-1", "uniprot_id": [ { "id": "TET1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URK3", "type": "external" } ], "mass": 222945.0, "length": 2039, "protein_name": "Methylcytosine dioxygenase TET1", "gene_name": "Tet1", "organism": "Mouse", "refseq_name": "methylcytosine dioxygenase TET1 isoform 1", "refseq_ac": [ { "id": "NP_001240786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240786", "type": "external" } ], "gene_names_uniprotkb": "Tet1; Cxxc6; Kiaa1676", "gene_names_refseq": "2510010B09Rik; Cxxc6; D10Ertd17e; LCX; Tet1; mKIAA1676", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET1; 1.14.11.80; CXXC-type zinc finger protein 6; Ten-eleven translocation 1 gene protein homolog", "protein_names_refseq": "CXXC finger 6; CXXC-type zinc finger protein 6; methylcytosine dioxygenase TET1 isoform 1; methylcytosine dioxygenase TET1; ten-eleven translocation 1 gene protein homolog; tet oncogene 1", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:52463)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "20639862;21451524;21490601;21496894;21514197;21606357;21750661;21778364;21816367;23151479;23352454;23352810;23729667;24357321;25284789;25557551;25568311;27916660;28504700;28531272;28554894;28855337;31089182;32286661;32855402;33262245;33895792;34166371;36056023;36852467;40128797;40155743", "class_list": "", "function": "Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dioxygenase that plays a key role in active DNA demethylation (PubMed:27916660, PubMed:36056023). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (PubMed:27916660). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (PubMed:36056023). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared with isoform 1, although some overlap between both isoforms, hence differentially regulating excitatory synaptic transmission (PubMed:33262245). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (PubMed:33262245). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (PubMed:33262245). In immature and partially differentiated gonadotrope cells, represses luteinizing hormone gene LHB expression directly and does not catalyze 5hmC at the gene promoter (PubMed:28855337)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Dioxygenase that plays a key role in active DNA demethylation (PubMed:27916660, PubMed:36056023). Binds to promoters, particularly to those with high CG content (PubMed:27916660). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (PubMed:33262245). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (PubMed:33262245). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (PubMed:33262245)., [UniProtKB, PubMed, PubMed, PubMed]; Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:20639862, PubMed:21496894, PubMed:21778364). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:28504700, PubMed:32286661). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, iron homeostasis, neural activity or DNA repair (PubMed:20639862, PubMed:31089182, PubMed:32855402, PubMed:33895792). Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification (PubMed:20639862, PubMed:28504700). Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (By similarity). May play a role in the pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (By similarity). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (PubMed:34166371). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (PubMed:23151479). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "D0VLQ4;E9Q9Y4;Q6ZPK2;Q9CY36", "ec_number_list": [ { "id": "1.14.11.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.80", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005694 chromosome", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "Q3URK3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35330-1", "uniprot_id": [ { "id": "ICAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35330", "type": "external" } ], "mass": 31390.0, "length": 277, "protein_name": "Intercellular adhesion molecule 2", "gene_name": "Icam2", "organism": "Mouse", "refseq_name": "intercellular adhesion molecule 2 precursor", "refseq_ac": [ { "id": "NP_034624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034624", "type": "external" } ], "gene_names_uniprotkb": "Icam2", "gene_names_refseq": "CD102; Icam-2; Icam2; Ly-60", "protein_names_uniprotkb": "Intercellular adhesion molecule 2; ICAM-2; Lymphocyte function-associated AG-1 counter-receptor", "protein_names_refseq": "intercellular adhesion molecule 2 precursor; lymphocyte function-associated AG-1 counter-receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:15896); (R-MMU-198933); (R-MMU-216083); (R-MMU-5621575)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;1401904;21750661;38126167;9472040", "class_list": "glycogene", "function": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1401904). Also endothelial blood vessels receptor ligand of dendritic cell (DC) CD209 signaling receptor that mediates triggering transendothelial migration of DC presursors from blood into peripheral tissues and, subsequently, into lymphoid tissues. Mediates adhesive interactions important for antigen presentation, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity)., [UniProtKB, UniProtKB, PubMed]; ICAM2 is related to good prognosis in dendritic cell immunotherapy for cancer., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8Q4", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032154 cleavage furrow;GO:0071944 cell periphery;GO:0005902 microvillus;GO:0001931 uropod", "go_biological_process": "GO:0007155 cell adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion;GO:0036336 dendritic cell migration;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35330-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TPJ7-1", "uniprot_id": [ { "id": "MIDN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TPJ7", "type": "external" } ], "mass": 49192.0, "length": 465, "protein_name": "Midnolin", "gene_name": "Midn", "organism": "Mouse", "refseq_name": "midnolin isoform 2", "refseq_ac": [ { "id": "NP_001292727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292727", "type": "external" } ], "gene_names_uniprotkb": "Midn", "gene_names_refseq": "3000003C15Rik; Midn", "protein_names_uniprotkb": "Midnolin; Midbrain nucleolar protein", "protein_names_refseq": "midbrain nucleolar protein; midnolin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:59090)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10974535;21750661;24187134;27326929;32782141;36852467;37129245;38625151;39627609", "class_list": "", "function": "Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (By similarity). Promotes also the degradation of other substrates such as CBX4 (PubMed:27326929). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose., [RefSeq, PubMed]; Midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells, [RefSeq, PubMed]; This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Viable mutations of mouse midnolin suppress B cell malignancies., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3X5;Q9JJJ6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0033132 negative regulation of glucokinase activity;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3TPJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48356-1", "uniprot_id": [ { "id": "LEPR_MOUSE", "url": "https://www.uniprot.org/uniprot/P48356", "type": "external" } ], "mass": 130789.0, "length": 1162, "protein_name": "Leptin receptor", "gene_name": "Lepr", "organism": "Mouse", "refseq_name": "leptin receptor isoform 3 precursor", "refseq_ac": [ { "id": "NP_001116371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116371", "type": "external" } ], "gene_names_uniprotkb": "Lepr; Db; Obr", "gene_names_refseq": "B219; LEP-R; LEPROT; Leprb; Lepr; Modb1; OB-RGRP; Obr; db; diabetes; obese-like; obl", "protein_names_uniprotkb": "Leptin receptor; B219; LEP-R; OB receptor; OB-R", "protein_names_refseq": "OB receptor; leptin receptor gene-related protein; leptin receptor isoform 3 precursor", "tax_id": 10090, "disease": "sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); short bowel syndrome (Disease Ontology:DOID:10605); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); arteriosclerosis (Disease Ontology:DOID:2349); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diastolic heart failure (Disease Ontology:DOID:9775); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16847)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10660043;10799542;11018044;11108838;11861497;11923481;12196522;12594516;17620316;17726024;20223942;21183079;21750661;25232147;25383904;8548812;8608603;8616721;8628397;8692797;9322935;9344648;9732873;9845674", "class_list": "", "function": "Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis., [UniProtKB, PubMed]; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942)., [UniProtKB, PubMed, PubMed, PubMed]; Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:11861497, PubMed:11923481, PubMed:25383904). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:11923481, PubMed:25383904). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 5, "disease_count": 27, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O35686;O54986;Q61215;Q64309;Q9QWG3;Q9QWV5", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019953 sexual reproduction;GO:1903999 negative regulation of eating behavior;GO:1904060 negative regulation of locomotor rhythm;GO:0001525 angiogenesis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P48356-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70211-1", "uniprot_id": [ { "id": "DCC_MOUSE", "url": "https://www.uniprot.org/uniprot/P70211", "type": "external" } ], "mass": 158341.0, "length": 1447, "protein_name": "Netrin receptor DCC", "gene_name": "Dcc", "organism": "Mouse", "refseq_name": "netrin receptor DCC precursor", "refseq_ac": [ { "id": "NP_031857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031857", "type": "external" } ], "gene_names_uniprotkb": "Dcc", "gene_names_refseq": "C030036D22Rik; Dcc; Igdcc1", "protein_names_uniprotkb": "Netrin receptor DCC; Tumor suppressor protein DCC", "protein_names_refseq": "deleted in colorectal carcinoma; netrin receptor DCC precursor; netrin receptor DCC; tumor suppressor protein DCC", "tax_id": 10090, "disease": "mirror movements 1 (Disease Ontology:DOID:0070636); depressive disorder (Disease Ontology:DOID:1596); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13176); (R-MMU-373752); (R-MMU-418885); (R-MMU-418889)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11533026;15494734;18585357;21321230;22220752;22645316;28250456;29782851;30899004;32848054;33300544;40885482;8570174", "class_list": "", "function": "Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 4, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "G3X9X6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001764 neuron migration;GO:0006915 apoptotic process;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70211-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48722-1", "uniprot_id": [ { "id": "HS74L_MOUSE", "url": "https://www.uniprot.org/uniprot/P48722", "type": "external" } ], "mass": 94382.0, "length": 838, "protein_name": "Heat shock 70 kDa protein 4L", "gene_name": "Hspa4l", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 4L isoform 1", "refseq_ac": [ { "id": "NP_035150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035150", "type": "external" } ], "gene_names_uniprotkb": "Hspa4l; Apg1; Hsp4l; Hsph3; Osp94", "gene_names_refseq": "94kDa; APG-1; Hspa4l; Osp94", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4L; Heat shock 70-related protein APG-1; Osmotic stress protein 94", "protein_names_refseq": "heat shock 70 kDa protein 4L isoform 1; heat shock 70 kDa protein 4L; heat shock 70-related protein APG-1; heat shock 70kDa protein 4 like; osmotic stress protein 94", "tax_id": 10090, "disease": "", "pathway": " (mmu:18415); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16923965;17114649;17525332;21183079;21750661;22645316;23980576;24788674;30914484;33894646;37507081;8647834;9006898", "class_list": "", "function": "HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth., [RefSeq, PubMed]; Heat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice., [RefSeq, PubMed]; Hspa4l-null mice showed male infertility and the malformation of sperm heads. Hspa4l enhanced the release of Ppp1cc2 from complexes with Hsp70 and Hsc70. Introduction of a Prm2 S56A mutation to Hspa4l-null mice restored the malformation of sperm heads and the infertility of Hspa4l (-/-) mice. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase., [UniProtKB]; These results provide evidence that Hspa4l is required for normal spermatogenesis and suggest that Hspa4l plays a role in osmotolerance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97854;Q3TQN2;Q3UNG4;Q8BQD0;Q8CC45;Q91X29", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P48722-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08048-1", "uniprot_id": [ { "id": "HGF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08048", "type": "external" } ], "mass": 82945.0, "length": 728, "protein_name": "Hepatocyte growth factor", "gene_name": "Hgf", "organism": "Mouse", "refseq_name": "hepatocyte growth factor isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001276387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276387", "type": "external" } ], "gene_names_uniprotkb": "Hgf", "gene_names_refseq": "C230052L06Rik; HGF/SF; Hgf; NK1; NK2; SF/HGF; SF", "protein_names_uniprotkb": "Hepatocyte growth factor; Hepatopoietin-A; SF; Scatter factor", "protein_names_refseq": "hepatocyte growth factor isoform 1 preproprotein; hepatopoietin-A; scatter factor", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); limb ischemia (Disease Ontology:DOID:0050852); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); graft-versus-host disease (Disease Ontology:DOID:0081267); autosomal recessive nonsyndromic deafness 39 (Disease Ontology:DOID:0110497); keratoconus (Disease Ontology:DOID:10126); dermatomyositis (Disease Ontology:DOID:10223); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); myopia (Disease Ontology:DOID:11830); vitiligo (Disease Ontology:DOID:12306); retinopathy of prematurity (Disease Ontology:DOID:13025); angle-closure glaucoma (Disease Ontology:DOID:13550); adult-onset Still's disease (Disease Ontology:DOID:14256); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); inverted papilloma (Disease Ontology:DOID:3179); central nervous system disease (Disease Ontology:DOID:331); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); meningioma (Disease Ontology:DOID:3565); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466); localized scleroderma (Disease Ontology:DOID:8472); cholesteatoma (Disease Ontology:DOID:869); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15234); (R-MMU-114608); (R-MMU-1257604); (R-MMU-5673001); (R-MMU-6806942); (R-MMU-6807004); (R-MMU-6811558); (R-MMU-8851805); (R-MMU-8851907); (R-MMU-8865999); (R-MMU-8874081); (R-MMU-8875513); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-8875791); (R-MMU-9734091)", "pathway_count": 16, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17804794;1831975;20624990;2142751;2144630;34428180;37642183;37913847;37981065;7822318;8081873;8135822;8241272;9488442", "class_list": "", "function": "Extracellular vesicles of iPS cells highly capable of producing HGF and TGF-beta1 can attenuate Sjogren's syndrome via innate immunity regulation., [RefSeq, PubMed]; Hepatocyte growth factor attenuates high glucose-disturbed mitochondrial dynamics in podocytes by decreasing ARF6-dependent DRP1 translocation., [RefSeq, PubMed]; Intercellular Interactions Mediated by HGF And TGF-Beta Promote the 3D Spherical and Xenograft Growth of Liver Cancer Cells., [RefSeq, PubMed]; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9420, "biomarker_type": "", "glycan_count": 2, "disease_count": 46, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O55027;Q53WS5;Q61662;Q64007;Q6LBE6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0001889 liver development;GO:0006508 proteolysis;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q08048-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ND04-1", "uniprot_id": [ { "id": "HSF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5ND04", "type": "external" } ], "mass": 67316.0, "length": 624, "protein_name": "Heat shock factor protein 5", "gene_name": "Hsf5", "organism": "Mouse", "refseq_name": "heat shock factor protein 5", "refseq_ac": [ { "id": "NP_001038992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038992", "type": "external" } ], "gene_names_uniprotkb": "Hsf5; Gm739", "gene_names_refseq": "Gm739; Hsf5; MLZ-220", "protein_names_uniprotkb": "Heat shock factor protein 5; HSF 5; HSTF 5; Heat shock transcription factor 5; MLZ-220; Protein expressed in male leptotene and zygotene spermatocytes 220", "protein_names_refseq": "HSF 5; HSTF 5; heat shock factor protein 5; heat shock transcription factor 5; protein expressed in male leptotene and zygotene spermatocytes 220", "tax_id": 10090, "disease": "", "pathway": " (mmu:327992)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20339383;21183079;37206036;38684656", "class_list": "", "function": "Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions (PubMed:38684656). Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes (PubMed:38684656)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KGG8;Q3TLD8", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0001216 DNA-binding transcription activator activity;GO:0001217 DNA-binding transcription repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001741 XY body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ND04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2X1-1", "uniprot_id": [ { "id": "HNRPF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2X1", "type": "external" } ], "mass": 45730.0, "length": 415, "protein_name": "Heterogeneous nuclear ribonucleoprotein F", "gene_name": "Hnrnpf", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein F", "refseq_ac": [ { "id": "NP_001159899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159899", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpf; Hnrpf", "gene_names_refseq": "4833420I20Rik; Hnrnpf; Hnrpf", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein F; hnRNP F", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein F; hnRNP F", "tax_id": 10090, "disease": "renal glycosuria (Disease Ontology:DOID:9432)", "pathway": " (mmu:98758); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "18299400;21183079;21750661;21952136;23806337;24788674;25153642;25605945;26740625;28135057;28528544;29187734;31219806;34428180;35820727;35984892;37453647;38195017;40997131", "class_list": "", "function": "Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)., [UniProtKB]; Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWK2;Q8BVU8;Q8K2U9;Q8R0E7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0071013 catalytic step 2 spliceosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z2X1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I1X5-1", "uniprot_id": [ { "id": "IASPP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5I1X5", "type": "external" } ], "mass": 88976.0, "length": 824, "protein_name": "RelA-associated inhibitor", "gene_name": "Ppp1r13l", "organism": "Mouse", "refseq_name": "relA-associated inhibitor", "refseq_ac": [ { "id": "NP_001010836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010836", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r13l; Nkip1", "gene_names_refseq": "IASPP; Nkip1; Ppp1r13l; wa3", "protein_names_uniprotkb": "RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1; PPP1R13B-like protein; Protein iASPP", "protein_names_refseq": "NFkB interacting protein 1; PPP1R13B-like protein; inhibitor of ASPP protein; protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; relA-associated inhibitor", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); autosomal recessive disease (Disease Ontology:DOID:0050737)", "pathway": " (mmu:333654); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15661756;19144319;19263435;21183079;21750661;22872234;24129315;28069640;31219806;33128543;33332723;34203471;34428180;36210013;36288343;37270580", "class_list": "", "function": "IASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Erratum:[Acta Biochim Biophys Sin (Shanghai). 2021 Dec 8;53(12):1739. doi: 10.1093/abbs/gmaa168. PMID: 33336692], [RefSeq, PubMed]; Mice with mutation in Nkip1 (Ppp1r13l) represent a potentially important model for the analysis of the role of inflammatory processes in heart disease., [RefSeq, PubMed]; P53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer., [RefSeq, PubMed]; Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640)., [UniProtKB, UniProtKB, PubMed]; Studies revealed that overexpression of PPP1R13L causes faster p53 degradation, a likely explanation for the depletion of p53., [RefSeq, PubMed]; Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by upregulating Nrf2 signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030054 cell junction;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q5I1X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57016-1", "uniprot_id": [ { "id": "LAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P57016", "type": "external" } ], "mass": 58864.0, "length": 528, "protein_name": "Ladinin-1", "gene_name": "Lad1", "organism": "Mouse", "refseq_name": "ladinin-1", "refseq_ac": [ { "id": "NP_598425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598425", "type": "external" } ], "gene_names_uniprotkb": "Lad1", "gene_names_refseq": "LADA; Lad1; lad-1", "protein_names_uniprotkb": "Ladinin-1; LADA; Lad-1; Linear IgA disease antigen homolog", "protein_names_refseq": "ladinin-1; linear IgA disease antigen homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:16763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;27802388;9119369", "class_list": "", "function": "Anchoring filament protein which is a component of the basement membrane zone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005604 basement membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P57016-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15702-1", "uniprot_id": [ { "id": "LEUK_MOUSE", "url": "https://www.uniprot.org/uniprot/P15702", "type": "external" } ], "mass": 40038.0, "length": 395, "protein_name": "Leukosialin", "gene_name": "Spn", "organism": "Mouse", "refseq_name": "leukosialin precursor", "refseq_ac": [ { "id": "NP_001032899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032899", "type": "external" } ], "gene_names_uniprotkb": "Spn", "gene_names_refseq": "A630014B01Rik; Cd43; Galgp; Ly-48; Ly48; Spn", "protein_names_uniprotkb": "Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Ly-48; Lymphocyte antigen 48; Sialophorin", "protein_names_refseq": "3E8 antigen; B-cell differentiation antigen LP-3; leukocyte sialoglycoprotein; leukosialin precursor; leukosialin; lymphocyte antigen 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:20737); (R-MMU-202733); (R-MMU-210991)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11078605;11238599;11728336;17638845;18490738;18614175;19696198;1973410;21183079;21289089;2144340;21750661;2347365;26700769;38673806;39627609;7514104", "class_list": "", "function": "Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (PubMed:11728336, PubMed:17638845, PubMed:21289089). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment (PubMed:18490738). Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (By similarity). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin (PubMed:26700769). Acts as a T-cell counter-receptor for SIGLEC1 (PubMed:11238599)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Protects cells from apoptotic signals, promoting cell survival., [UniProtKB, PubMed]; Runx3 Regulates CD8[+] T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019904 protein domain specific binding;GO:0031072 heat shock protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0002296 T-helper 1 cell lineage commitment;GO:0001934 positive regulation of protein phosphorylation;GO:0007162 negative regulation of cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:2000406 positive regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P15702-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5G3-1", "uniprot_id": [ { "id": "KIF23_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5G3", "type": "external" } ], "mass": 108776.0, "length": 953, "protein_name": "Kinesin-like protein KIF23", "gene_name": "Kif23", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF23 isoform 2", "refseq_ac": [ { "id": "NP_077207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077207", "type": "external" } ], "gene_names_uniprotkb": "Kif23", "gene_names_refseq": "3110001D19Rik; CHO1; Kif23; Knsl5; MKLP-1; MKLP1", "protein_names_uniprotkb": "Kinesin-like protein KIF23", "protein_names_refseq": "kinesin-like 5 (mitotic kinesin-like protein 1); kinesin-like protein KIF23 isoform 2; kinesin-like protein KIF23", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia type IIIa (Disease Ontology:DOID:0111399)", "pathway": " (mmu:71819); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-68884); (R-MMU-983189)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11416179;19020301;19144319;21183079;21750661;22522702;25428506;28528544;30016717;31219806;32818800;34428180;36210013;38569671", "class_list": "", "function": "Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro (By similarity)., [UniProtKB]; Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III., [RefSeq, PubMed]; Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80V30;Q99PT8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0007018 microtubule-based movement;GO:0032467 positive regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "E9Q5G3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP89-1", "uniprot_id": [ { "id": "LACTB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP89", "type": "external" } ], "mass": 60705.0, "length": 551, "protein_name": "Serine beta-lactamase-like protein LACTB, mitochondrial", "gene_name": "Lactb", "organism": "Mouse", "refseq_name": "serine beta-lactamase-like protein LACTB, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_109642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109642", "type": "external" } ], "gene_names_uniprotkb": "Lactb; Lact1", "gene_names_refseq": "LACT-1; Lact1; Lactb; Mrpl56", "protein_names_uniprotkb": "Serine beta-lactamase-like protein LACTB, mitochondrial; 3.4.-.-", "protein_names_refseq": "mitochondrial ribosomal protein L56; serine beta lactamase-like protein; serine beta-lactamase-like protein LACTB, mitochondrial isoform 1 precursor; serine beta-lactamase-like protein LACTB, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:80907)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11707067;21750661;23576753;23806337;25428506;28329758;30084848;30216112;30779550;32152506;34428180;37453647;37507081", "class_list": "", "function": "Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758)., [UniProtKB, UniProtKB, PubMed]; These findings indicate that miRNA-351-5p functions in skeletal myogenesis by targeting LACTB and is regulated by lnc-mg, supporting the role of the competing endogenous RNA network in skeletal myogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EP89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3Y3-1", "uniprot_id": [ { "id": "LN28A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3Y3", "type": "external" } ], "mass": 22720.0, "length": 209, "protein_name": "Protein lin-28 homolog A", "gene_name": "Lin28a", "organism": "Mouse", "refseq_name": "protein lin-28 homolog A", "refseq_ac": [ { "id": "NP_665832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665832", "type": "external" } ], "gene_names_uniprotkb": "Lin28a; Lin28; Tex17", "gene_names_refseq": "Gm10299; Lin-28; Lin28a; Lin28; Tex17; lin-28A", "protein_names_uniprotkb": "Protein lin-28 homolog A; Lin-28A; Testis-expressed protein 17", "protein_names_refseq": "RNA-binding protein LIN-28; protein lin-28 homolog A; testis expressed gene 17; testis-expressed protein 17", "tax_id": 10090, "disease": "nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:83557)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11279525;12798299;14643679;15003116;15722555;16227573;17473174;18292307;18566191;18604195;19703396;21750661;22078496;23102813;24209617;26045559;28179426;28671666;37188880;37774938;38341436;38729326;39148295", "class_list": "", "function": "Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia., [RefSeq, PubMed]; Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury., [RefSeq, PubMed]; Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state., [RefSeq, PubMed]; MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway., [RefSeq, PubMed]; MicroRNA regulation is a conserved feature of the Lin-28 gene in diverse animals. Erratum:[Dev Biol. 2003 Oct 15;262(2):361], [RefSeq, PubMed]; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18292307, PubMed:18566191, PubMed:18604195, PubMed:19703396, PubMed:23102813, PubMed:24209617). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813). Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Temporally regulated expression of Lin-28 in the mouse embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NV62", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0045666 positive regulation of neuron differentiation;GO:0048863 stem cell differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0060964 regulation of miRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8K3Y3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55203-1", "uniprot_id": [ { "id": "LDB2_MOUSE", "url": "https://www.uniprot.org/uniprot/O55203", "type": "external" } ], "mass": 42691.0, "length": 373, "protein_name": "LIM domain-binding protein 2", "gene_name": "Ldb2", "organism": "Mouse", "refseq_name": "LIM domain-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001070866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070866", "type": "external" } ], "gene_names_uniprotkb": "Ldb2; Clim1", "gene_names_refseq": "CLIM1; CLP-36; Ldb2; Ldb3", "protein_names_uniprotkb": "LIM domain-binding protein 2; CLIM-1; Carboxyl-terminal LIM domain-binding protein 1; LDB-2; LIM domain-binding factor CLIM1", "protein_names_refseq": "LIM domain-binding factor CLIM1; LIM domain-binding protein 2 isoform 2; LIM domain-binding protein 2; carboxyl-terminal LIM domain-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16826)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10330499;11882901;16815859;19675209;21750661;33656268;34428180;35836803;36210013;9192866;9860983", "class_list": "", "function": "CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Publication Status: Online-Only, [RefSeq, PubMed]; Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia., [RefSeq, PubMed]; Regulates the transcriptional activity of LIM-containing proteins such as LHX3 or PITX1., [UniProtKB, PubMed]; Transcription cofactor (PubMed:9192866). Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:9192866)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55205;Q3UHY1;Q6AXE6", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030334 regulation of cell migration;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKS4-1", "uniprot_id": [ { "id": "LDB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKS4", "type": "external" } ], "mass": 76432.0, "length": 723, "protein_name": "LIM domain-binding protein 3", "gene_name": "Ldb3", "organism": "Mouse", "refseq_name": "LIM domain-binding protein 3 isoform b", "refseq_ac": [ { "id": "NP_001034160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034160", "type": "external" } ], "gene_names_uniprotkb": "Ldb3; Kiaa0613", "gene_names_refseq": "Ldb3; PDLIM6; ZASP", "protein_names_uniprotkb": "LIM domain-binding protein 3; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ-motif protein", "protein_names_refseq": "LIM domain-binding protein 3 isoform b; LIM domain-binding protein 3; PDZ-LIM domain protein; Z-band alternatively spliced PDZ-motif protein; cypher; oracle protein; protein cypher; protein oracle", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); congenital myopathy (Disease Ontology:DOID:0081337); dilated cardiomyopathy 1C (Disease Ontology:DOID:0110423); distal myopathy (Disease Ontology:DOID:11720); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:24131)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10391924;10427098;10727866;12499364;21183079;21750661;24129315;30016717;30084848;34158421;37507081;39927985", "class_list": "", "function": "May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RSB0;B7ZNT6;Q6A038;Q811P2;Q811P3;Q811P4;Q811P5;Q9D130;Q9JKS3;Q9R0Z1;Q9WVH1;Q9WVH2", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0048471 perinuclear region of cytoplasm;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0045214 sarcomere organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JKS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06795-1", "uniprot_id": [ { "id": "MDR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P06795", "type": "external" } ], "mass": 140994.0, "length": 1276, "protein_name": "ATP-dependent translocase ABCB1", "gene_name": "Abcb1b", "organism": "Mouse", "refseq_name": "ATP-dependent translocase ABCB1", "refseq_ac": [ { "id": "NP_035205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035205", "type": "external" } ], "gene_names_uniprotkb": "Abcb1b; Abcb1; Mdr1b; Mdr1; Pgy1-1; Pgy1", "gene_names_refseq": "Abcb1b; Abcb1; Mdr1b; Mdr1; Pgy-1; Pgy1; mdr", "protein_names_uniprotkb": "ATP-dependent translocase ABCB1; 7.6.2.1; 7.6.2.2; ATP-binding cassette sub-family B member 1B; Multidrug resistance protein 1B; P-glycoprotein 1; Phospholipid transporter ABCB1", "protein_names_refseq": "ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-dependent translocase ABCB1; P glycoprotein 1; multidrug resistance protein 1B; multidrug resistance protein 1; phospholipid transporter ABCB1", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18669)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19144319;21750661;2248681;25605945;2570420;33300544;34428180;35341895;35997049;36270516;3768958;38426412;38522903", "class_list": "", "function": "Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation., [RefSeq, PubMed]; Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation., [RefSeq, PubMed]; Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1., [RefSeq, PubMed]; Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice., [RefSeq, PubMed]; Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]., [RefSeq]; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 43, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0001894 tissue homeostasis;GO:0035640 exploration behavior;GO:0045332 phospholipid translocation;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06795-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14873-1", "uniprot_id": [ { "id": "MAP1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P14873", "type": "external" } ], "mass": 270255.0, "length": 2464, "protein_name": "Microtubule-associated protein 1B", "gene_name": "Map1b", "organism": "Mouse", "refseq_name": "microtubule-associated protein 1B", "refseq_ac": [ { "id": "NP_032660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032660", "type": "external" } ], "gene_names_uniprotkb": "Map1b; Mtap1b; Mtap5", "gene_names_refseq": "A230055D22; LC1; MAP5; Map1b; Mtap-5; Mtap1b; Mtap5", "protein_names_uniprotkb": "Microtubule-associated protein 1B; MAP-1B; MAP1(X); MAP1.2", "protein_names_refseq": "MAP-1B; MAP1(X); MAP1.2; Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)); microtubule-associated protein 1B; microtubule-associated protein 5", "tax_id": 10090, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); autosomal dominant nonsyndromic deafness 83 (Disease Ontology:DOID:0070609); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:17755)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "12147674;12807913;15345747;16452087;17114649;17320046;17704770;18075266;19131326;20485683;21183079;21288476;21750661;21984824;22517741;24129315;2480963;25428506;25775433;28528544;30084848;31219806;31277379;31711525;32848054;33268592;33300544;34418053;34678516;35820727;35822049;38316337;38757694;40021952;40885482", "class_list": "", "function": "FMRP regulates postnatal neuronal migration via MAP1B. Publication Status: Online-Only, [RefSeq, PubMed]; Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation., [UniProtKB, PubMed, PubMed, PubMed]; The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 100, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9QM11", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding;GO:0005519 cytoskeletal regulatory protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097457 hippocampal mossy fiber;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0047497 mitochondrion transport along microtubule;GO:0061162 establishment of monopolar cell polarity;GO:0007409 axonogenesis;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P14873-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHK3-1", "uniprot_id": [ { "id": "MBOA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHK3", "type": "external" } ], "mass": 53436.0, "length": 473, "protein_name": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "gene_name": "Mboat7", "organism": "Mouse", "refseq_name": "membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "refseq_ac": [ { "id": "NP_084210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084210", "type": "external" } ], "gene_names_uniprotkb": "Mboat7; Bb1; Leng4; Lpiat1; Oact7", "gene_names_refseq": "5730589L02Rik; BB1; LPLAT 7; Leng4; Lpiat1; Lpiat; Mboat7; m-mboa-7", "protein_names_uniprotkb": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7; 1-acylglycerophosphatidylinositol O-acyltransferase; 2.3.1.-; Bladder and breast carcinoma-overexpressed gene 1 protein; LPIAT1; LPLAT 7; Leukocyte receptor cluster member 4; Lysophosphatidylinositol acyltransferase 1; Lysophospholipid acyltransferase 7; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7; m-mboa-7", "protein_names_refseq": "1-acylglycerophosphatidylinositol O-acyltransferase; bladder and breast carcinoma-overexpressed gene 1 protein; leukocyte receptor cluster (LRC) member 4; lysophosphatidylinositol acyltransferase 1; lysophospholipid acyltransferase 7; membrane-bound O-acyltransferase domain-containing protein 7; membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 57 (Disease Ontology:DOID:0081219); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:77582); (R-MMU-1482922)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15065000;18094042;21746835;21750661;23097495;23472195;31219806;32253259;33300544;37217003;38648183", "class_list": "", "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:23097495, PubMed:23472195, PubMed:32253259). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:23097495, PubMed:23472195). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259)., [UniProtKB, PubMed, PubMed, PubMed]; Congenital hydrocephalus in Mboat 7 null mice, [RefSeq, PubMed]; Data show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7) plays a crucial role in brain development in mice., [RefSeq, PubMed]; LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles., [RefSeq, PubMed]; LPIAT1 has an essential role in maintaining physiological levels of PtdIns and PtdInsP(2) in the mouse, [RefSeq, PubMed]; Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDM6;Q8R1P9;Q9CY76", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" } ], "go_molecular_function": "GO:0071617 lysophospholipid acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006661 phosphatidylinositol biosynthetic process;GO:0021819 layer formation in cerebral cortex;GO:0021591 ventricular system development;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CHK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PER3-1", "uniprot_id": [ { "id": "MARE3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PER3", "type": "external" } ], "mass": 31966.0, "length": 281, "protein_name": "Microtubule-associated protein RP/EB family member 3", "gene_name": "Mapre3", "organism": "Mouse", "refseq_name": "microtubule-associated protein RP/EB family member 3 isoform 1", "refseq_ac": [ { "id": "NP_579928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579928", "type": "external" } ], "gene_names_uniprotkb": "Mapre3", "gene_names_refseq": "EB2; EB3; EBF3; Mapre3; RP3", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 3; EB1 protein family member 3; EB3; EBF3; End-binding protein 3; RP3", "protein_names_refseq": "EB1 protein family member 3; end-binding protein 3; microtubule-associated protein RP/EB family member 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100732)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17114649;17310996;18283108;21183079;21646404;21750661;24706950;34428180;35216391", "class_list": "", "function": "Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid. Publication Status: Online-Only, [RefSeq, PubMed]; DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling., [RefSeq, PubMed]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61167", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription;GO:0031113 regulation of microtubule polymerization;GO:0048148 behavioral response to cocaine", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6PER3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Q1-1", "uniprot_id": [ { "id": "MARC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Q1", "type": "external" } ], "mass": 38194.0, "length": 338, "protein_name": "Mitochondrial amidoxime reducing component 2", "gene_name": "Mtarc2", "organism": "Mouse", "refseq_name": "mitochondrial amidoxime reducing component 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_598445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598445", "type": "external" } ], "gene_names_uniprotkb": "Mtarc2; Marc2; Mg87; Mosc2", "gene_names_refseq": "2810484M10Rik; Marc2; Mosc2; Mtarc2; mARC1", "protein_names_uniprotkb": "Mitochondrial amidoxime reducing component 2; 1.7.-.-; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; mARC2", "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; mitochondrial amidoxime reducing component 2 isoform 1 precursor; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67247); (R-MMU-211945)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17768142;21750661;23576753;25605945;27802388;28135057;31554661;34428180;35820727;37453647", "class_list": "", "function": "Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Striking phenotypical features of MARC2 Knockout Mice mice were lower body weight, increased body temperature, decreased levels of total cholesterol, and increased glucose levels, supporting previous findings that MARC2 affects energy pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q922Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1L5-1", "uniprot_id": [ { "id": "MAST1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1L5", "type": "external" } ], "mass": 170997.0, "length": 1570, "protein_name": "Microtubule-associated serine/threonine-protein kinase 1", "gene_name": "Mast1", "organism": "Mouse", "refseq_name": "microtubule-associated serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_064329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064329", "type": "external" } ], "gene_names_uniprotkb": "Mast1; Kiaa0973; Sast", "gene_names_refseq": "9430008B02Rik; Mast1; SAST170; SAST", "protein_names_uniprotkb": "Microtubule-associated serine/threonine-protein kinase 1; 2.7.11.1; Syntrophin-associated serine/threonine-protein kinase", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 1; syntrophin associated serine/threonine kinase; syntrophin-associated serine-threonine protein kinase", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (Disease Ontology:DOID:0111403)", "pathway": " (mmu:56527)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10404183;16452087;21183079;21750661;30449657;34203471;34418053;34678516;34774870", "class_list": "", "function": "Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway., [RefSeq, PubMed]; Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQG9;Q80TN0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0007420 brain development;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9R1L5-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6T264-1", "uniprot_id": [ { "id": "MAML1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6T264", "type": "external" } ], "mass": 107726.0, "length": 1020, "protein_name": "Mastermind-like protein 1", "gene_name": "Maml1", "organism": "Mouse", "refseq_name": "mastermind-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_780543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780543", "type": "external" } ], "gene_names_uniprotkb": "Maml1; Kiaa0200", "gene_names_refseq": "D930008C07Rik; Mam-1; Mam1; Maml1; mKIAA0200", "protein_names_uniprotkb": "Mastermind-like protein 1; Mam-1", "protein_names_refseq": "mastermind like 1; mastermind-like protein 1 isoform 2; mastermind-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103806); (R-MMU-2122947); (R-MMU-350054); (R-MMU-8941856)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15019995;15187027;19144319;21183079;21750661;25038227;25428506;31038233;31219806;31416089", "class_list": "", "function": "A dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 inhibition, [RefSeq, PubMed]; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions., [UniProtKB, PubMed, PubMed]; DnMAML1 expression leads to robust precocious oligodendrocytes differentiation and premature axonal myelination in the spinal cord, possibly by upregulating Nkx2.2 and downregulating Pdgfra expression. Unexpectedly, at late embryonic stages, dnMAML1 expression dramatically increased the number of oligodendrocyte precursor cells (OPCs), indicating a stage-dependent effect of Notch signaling on OPC proliferation., [RefSeq, PubMed]; Neuron production in mouse cerebral cortex is coordinated by the MAML1., [RefSeq, PubMed]; There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505D8;Q5SUC2;Q6PDK3;Q6ZQG5;Q8BIU5;Q8R3T0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0002193 MAML1-RBP-Jkappa- ICN1 complex;GO:1990433 CSL-Notch-Mastermind transcription factor complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6T264-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23804-1", "uniprot_id": [ { "id": "MDM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P23804", "type": "external" } ], "mass": 54558.0, "length": 489, "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "Mdm2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Mdm2 isoform 2", "refseq_ac": [ { "id": "NP_001275515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275515", "type": "external" } ], "gene_names_uniprotkb": "Mdm2", "gene_names_refseq": "1700007J15Rik; Mdm-2; Mdm2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27; Double minute 2 protein; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2", "protein_names_refseq": "E3 ubiquitin-protein ligase Mdm2 isoform 2; E3 ubiquitin-protein ligase Mdm2; RING-type E3 ubiquitin transferase Mdm2; double minute 2 protein; oncoprotein Mdm2; p53-binding protein Mdm2; transformed mouse 3T3 cell double minute 2", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); breast cancer (Disease Ontology:DOID:1612); ichthyosis (Disease Ontology:DOID:1697); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); intermittent claudication (Disease Ontology:DOID:3669); liver disease (Disease Ontology:DOID:409); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); priapism (Disease Ontology:DOID:9286)", "pathway": " (mmu:17246); (R-MMU-198323); (R-MMU-2559580); (R-MMU-2559585); (R-MMU-3232142); (R-MMU-399719); (R-MMU-5689880); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-69541); (R-MMU-8941858); (R-MMU-9766229)", "pathway_count": 13, "publication_count": 33, "publication_id_list": "10075719;10611322;10713175;10906133;11359766;11588219;14642282;15195100;17110379;19833129;2026149;21183079;21303257;21750661;21804542;22624716;24504419;25088421;25428506;25543083;25605945;25751059;27568562;27956626;28892044;30084848;30779550;30879903;31557161;33468664;34428180;8660994;8917101", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219). Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity). Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity). Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity). Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity). Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (PubMed:14642282). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61040;Q64330;Q91XK7", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0003170 heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P23804-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49717-1", "uniprot_id": [ { "id": "MCM4_MOUSE", "url": "https://www.uniprot.org/uniprot/P49717", "type": "external" } ], "mass": 96736.0, "length": 862, "protein_name": "DNA replication licensing factor MCM4", "gene_name": "Mcm4", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM4", "refseq_ac": [ { "id": "NP_032591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032591", "type": "external" } ], "gene_names_uniprotkb": "Mcm4; Cdc21; Mcmd4", "gene_names_refseq": "19G; Cdc21; Mcm4; Mcmd4; mKIAA4003; mcdc21", "protein_names_uniprotkb": "DNA replication licensing factor MCM4; 3.6.4.12; CDC21 homolog; P1-CDC21", "protein_names_refseq": "CDC21 homolog; DNA replication licensing factor MCM4; P1-CDC21; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog", "tax_id": 10090, "disease": "immunodeficiency 54 (Disease Ontology:DOID:0111967)", "pathway": " (mmu:17217); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "10567526;12207017;21183079;21750661;22645316;23806337;24788674;25605945;26524493;28528544;30084848;31219806;31599954;32152506;34203471;34428180;35820727;36210013;37028609;37507081;39627609;7610039;9798653", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, PubMed]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]; E2F2 is upregulated by the ERK pathway and regulates decidualization via MCM4., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O89056", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:0006279 premeiotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P49717-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSJ2-1", "uniprot_id": [ { "id": "MAP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSJ2", "type": "external" } ], "mass": 96450.0, "length": 906, "protein_name": "Microtubule-associated protein 6", "gene_name": "Map6", "organism": "Mouse", "refseq_name": "microtubule-associated protein 6 isoform 3", "refseq_ac": [ { "id": "NP_001036820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036820", "type": "external" } ], "gene_names_uniprotkb": "Map6; Mtap6", "gene_names_refseq": "2810411E12Rik; Map-6; Map6; Mtap6; STOP", "protein_names_uniprotkb": "Microtubule-associated protein 6; MAP-6; STOP; Stable tubule-only polypeptide", "protein_names_refseq": "microtubule-associated protein 6 isoform 3; stable tubule-only polypeptide", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:17760)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12231625;12782132;14516200;15389836;16837464;17114649;18034455;21183079;21750661;22517741;22645316;23806337;25153642;26192747;26198635;28135057;28521134;28657654;32782141;32848054;33300544;34678516;35822049;40021952;40885482;9501006;9600916", "class_list": "", "function": "Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:9600916). Specifically has microtubule cold stabilizing activity (PubMed:9600916). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (PubMed:28521134)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; STOP-/- mice had no detectable defects in brain anatomy but showed synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 30, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 30, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 30, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "O55129;O70586;O70587;Q78DV4;Q78DV5", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0030424 axon", "go_biological_process": "GO:0048813 dendrite morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0050772 positive regulation of axonogenesis;GO:0032418 lysosome localization;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "Q7TSJ2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDG6-1", "uniprot_id": [ { "id": "M3K21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDG6", "type": "external" } ], "mass": 110112.0, "length": 1002, "protein_name": "Mitogen-activated protein kinase kinase kinase 21", "gene_name": "Map3k21", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 21", "refseq_ac": [ { "id": "NP_663583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663583", "type": "external" } ], "gene_names_uniprotkb": "Map3k21; Kiaa1804; Mlk4", "gene_names_refseq": "Map3k21; Mlk4; mKIAA1804", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 21; 2.7.11.25; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 21; mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:234878)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21602844;34428180", "class_list": "", "function": "MLK4 is a negative regulator of TLR4 signaling., [RefSeq, PubMed]; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTU6;Q811F5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004706 JUN kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VDG6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D067-1", "uniprot_id": [ { "id": "SAXO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D067", "type": "external" } ], "mass": 79689.0, "length": 708, "protein_name": "Stabilizer of axonemal microtubules 6", "gene_name": "Mdm1; Saxo6", "organism": "Mouse", "refseq_name": "nuclear protein MDM1 isoform 3", "refseq_ac": [ { "id": "NP_001156376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156376", "type": "external" } ], "gene_names_uniprotkb": "Mdm1; Saxo6; Mdm-1; Mdm1", "gene_names_refseq": "Arrd2; Mdm-1; Mdm1; Saxo6", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 6; Mdm4 transformed 3T3 cell double minute 1 protein; Mouse double minute 1; Nuclear protein MDM1", "protein_names_refseq": "MDM1 nuclear protein; double minute 1; mdm4 transformed 3T3 cell double minute 1 protein; nuclear protein MDM1 isoform 3; nuclear protein MDM1; transformed mouse 3T3 cell double minute 1", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:17245)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;26337392;3182840;34428180;36171205", "class_list": "", "function": "Mdm1 ablation results in retinal degeneration by specific intraflagellar transport defects of photoreceptor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61841;Q61842;Q9DBR6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005814 centriole", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0046600 negative regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D067-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1M4-1", "uniprot_id": [ { "id": "MCA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1M4", "type": "external" } ], "mass": 19859.0, "length": 174, "protein_name": "Eukaryotic translation elongation factor 1 epsilon-1", "gene_name": "Eef1e1", "organism": "Mouse", "refseq_name": "eukaryotic translation elongation factor 1 epsilon-1", "refseq_ac": [ { "id": "NP_079656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079656", "type": "external" } ], "gene_names_uniprotkb": "Eef1e1", "gene_names_refseq": "1110003A02Rik; AIMP3; Eef1e1", "protein_names_uniprotkb": "Eukaryotic translation elongation factor 1 epsilon-1; Elongation factor p18; Multisynthase complex auxiliary component p18", "protein_names_refseq": "elongation factor p18; eukaryotic translation elongation factor 1 epsilon-1; multisynthase complex auxiliary component p18; multisynthetase complex auxiliary component p18", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66143); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12060739;15680327;20726853;30302025;30858199;31219806;34428180", "class_list": "", "function": "AIMP3 is a specific regulator of mature lamin A and imply that enhanced expression of AIMP3 might be a factor driving cellular and/or organismal aging [AIMP3], [RefSeq, PubMed]; Gamma-H2AX removal was delayed, and homologous DNA repair activity was significantly reduced. Reduction of RPA foci formation and subsequent Rad51 foci formation probably underlie the significant reduction in homologous recombination activity in the absence of AIMP3. Together, our data demonstrate that AIMP3 plays a role in genome stability through the DNA repair process Publication Status: Online-Only, [RefSeq, PubMed]; High-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells., [RefSeq, PubMed]; Positive modulator of ATM response to DNA damage., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1M4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27808-1", "uniprot_id": [ { "id": "MGAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P27808", "type": "external" } ], "mass": 51690.0, "length": 447, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat1", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "NP_001103618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103618", "type": "external" } ], "gene_names_uniprotkb": "Mgat1; Gnt1", "gene_names_refseq": "Mgat-1; Mgat1", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.101; GNT-I; GlcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I", "protein_names_refseq": "GNT-I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; glcNAc-T I", "tax_id": 10090, "disease": "", "pathway": " (mmu:17308); (R-MMU-964739)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "1421759;1533386;20805325;21750661;26495903;27802388;28011936;31219806;31599954;34428180;35984892;36210013", "class_list": "glycogene;glycosyltransferase", "function": "Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006487 protein N-linked glycosylation;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 9485, "hit_score": 1.3, "record_id": "P27808-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26041-1", "uniprot_id": [ { "id": "MOES_MOUSE", "url": "https://www.uniprot.org/uniprot/P26041", "type": "external" } ], "mass": 67767.0, "length": 577, "protein_name": "Moesin", "gene_name": "Msn", "organism": "Mouse", "refseq_name": "moesin", "refseq_ac": [ { "id": "NP_034963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034963", "type": "external" } ], "gene_names_uniprotkb": "Msn", "gene_names_refseq": "Msn", "protein_names_uniprotkb": "Moesin; Membrane-organizing extension spike protein", "protein_names_refseq": "membrane-organizing extension spike protein; moesin", "tax_id": 10090, "disease": "immunodeficiency 50 (Disease Ontology:DOID:0112001); primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (mmu:17698); (R-MMU-437239)", "pathway_count": 2, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10947843;11425343;11777944;1429901;1573844;17947660;21167822;21183079;21327982;22875842;23806337;24127566;27301331;27976727;28978692;29187734;29247647;30084848;31219806;32152506;34428180;34887587;35820727;36100057;36160865;36288343;37453647;37507081;37828378;39627609;9456324;9472040;9856983;9890997", "class_list": "", "function": "Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (By similarity). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (By similarity). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (By similarity). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:22875842). Modulates phagolysosomal biogenesis in macrophages (PubMed:28978692). Also participates in immunologic synapse formation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AX70;Q3UL28;Q8BSN4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1902115 regulation of organelle assembly;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P26041-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQR7-1", "uniprot_id": [ { "id": "MAGBI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQR7", "type": "external" } ], "mass": 37203.0, "length": 327, "protein_name": "Melanoma-associated antigen B18", "gene_name": "Mageb18", "organism": "Mouse", "refseq_name": "melanoma-associated antigen B18", "refseq_ac": [ { "id": "NP_776144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776144", "type": "external" } ], "gene_names_uniprotkb": "Mageb18", "gene_names_refseq": "B430216B18Rik; Mageb18", "protein_names_uniprotkb": "Melanoma-associated antigen B18; MAGE-B18 antigen", "protein_names_refseq": "MAGE-B18 antigen; melanoma antigen family B, 18; melanoma-associated antigen B18", "tax_id": 10090, "disease": "", "pathway": " (mmu:215641)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22332604", "class_list": "", "function": "Demonstrate that knockdown of MAGEB18 inhibits the growth of B16-F0 cells and induces apoptosis, which correlates with increased levels of TP53 (tumour protein 53), p21, Bax and caspase 3, [RefSeq, PubMed]; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG2-1", "uniprot_id": [ { "id": "MET16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG2", "type": "external" } ], "mass": 62341.0, "length": 553, "protein_name": "RNA N(6)-adenosine-methyltransferase METTL16", "gene_name": "Mettl16", "organism": "Mouse", "refseq_name": "RNA N(6)-adenosine-methyltransferase METTL16", "refseq_ac": [ { "id": "NP_080473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080473", "type": "external" } ], "gene_names_uniprotkb": "Mettl16; Mett10d", "gene_names_refseq": "2610100D03Rik; 2810013M15Rik; A830095F14Rik; Mett10d; Mettl16", "protein_names_uniprotkb": "RNA N(6)-adenosine-methyltransferase METTL16; 2.1.1.346; 2.1.1.348; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase", "protein_names_refseq": "N6-adenosine-methyltransferase METTL16; RNA N(6)-adenosine-methyltransferase METTL16; RNA N6-adenosine-methyltransferase METTL16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; methyltransferase 10 domain containing; methyltransferase 10 domain-containing protein; methyltransferase like 16; methyltransferase-like protein 16; putative methyltransferase METT10D", "tax_id": 10090, "disease": "", "pathway": " (mmu:67493)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "20173027;21183079;21750661;29262316;30197299;31219806;34203471;34428180;35820727;37828378;38605226", "class_list": "", "function": "A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells., [RefSeq, PubMed]; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMA9;Q9D062", "ec_number_list": [ { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.346", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.346", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding;GO:0035613 RNA stem-loop binding;GO:0030629 U6 snRNA 3'-end binding;GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0010608 post-transcriptional regulation of gene expression;GO:0006402 mRNA catabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4R2-1", "uniprot_id": [ { "id": "MGT4D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4R2", "type": "external" } ], "mass": 43300.0, "length": 373, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D", "gene_name": "Mgat4d", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor", "refseq_ac": [ { "id": "NP_080509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080509", "type": "external" } ], "gene_names_uniprotkb": "Mgat4d", "gene_names_refseq": "4933434I20Rik; GnT1IP-L; GnT1IP; Mgat4d", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; GlcNAcT-I inhibitory protein; GnT1IP; N-acetylglucosaminyltransferase MGAT1 inhibitory protein", "protein_names_refseq": "GlcNAcT-I inhibitory protein; MGAT4 family, member C; N-acetylglucosaminyltransferase MGAT1 inhibitory protein; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; glycosyltransferase 54 domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67555)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20805325;26371870", "class_list": "glycogene;glycosyltransferase", "function": "May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E2F697;E9QM08", "ec_number_list": [], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006487 protein N-linked glycosylation;GO:0010561 negative regulation of glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D4R2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYR6-1", "uniprot_id": [ { "id": "MAP1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYR6", "type": "external" } ], "mass": 300140.0, "length": 2776, "protein_name": "Microtubule-associated protein 1A", "gene_name": "Map1a", "organism": "Mouse", "refseq_name": "microtubule-associated protein 1A isoform 2", "refseq_ac": [ { "id": "NP_001166977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166977", "type": "external" } ], "gene_names_uniprotkb": "Map1a; Mtap1a; Mtap1", "gene_names_refseq": "6330416M19Rik; Map1a; Mtap-1; Mtap1a; Mtap1; moth1", "protein_names_uniprotkb": "Microtubule-associated protein 1A; MAP-1A", "protein_names_refseq": "MAP-1A; microtubule-associated protein 1A isoform 2; modifier of tubby hearing 1; short MAP1A; short microtubule-associated protein 1A", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hypothyroidism (Disease Ontology:DOID:1459); hepatitis B (Disease Ontology:DOID:2043)", "pathway": " (mmu:17754)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11311937;16452087;17320046;18034455;19131326;21183079;21288476;21750661;22645316;25428506;28701415;29237092;31599954;32848054;35822049;36104704;37705167;40021952;40885482", "class_list": "", "function": "Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model., [RefSeq, PubMed]; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements., [UniProtKB]; Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 77, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "A2ARN9;Q3TQM8;Q3TUV8;Q3UHB7;Q9QZH9;Q9QZI0;Q9QZI1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0005518 collagen binding;GO:0008093 cytoskeletal anchor activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0099641 anterograde axonal protein transport;GO:0007409 axonogenesis;GO:0007613 memory;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9QYR6-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVS4-1", "uniprot_id": [ { "id": "MOK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVS4", "type": "external" } ], "mass": 48065.0, "length": 420, "protein_name": "MAPK/MAK/MRK overlapping kinase", "gene_name": "Mok", "organism": "Mouse", "refseq_name": "MAPK/MAK/MRK overlapping kinase isoform 1", "refseq_ac": [ { "id": "NP_036103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036103", "type": "external" } ], "gene_names_uniprotkb": "Mok; Rage; Stk30", "gene_names_refseq": "Mok; RAGE1; Rage; Stk30", "protein_names_uniprotkb": "MAPK/MAK/MRK overlapping kinase; 2.7.11.22; MOK protein kinase; Serine/threonine kinase 30", "protein_names_refseq": "MAPK/MAK/MRK overlapping kinase isoform 1; MAPK/MAK/MRK overlapping kinase; T/STK 30; renal tumor antigen; serine/threonine kinase 30", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:26448)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10421840;15327990;21750661;25243405;28336525;37315391;37399380", "class_list": "", "function": "Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (PubMed:10421840). Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner (PubMed:25243405)., [UniProtKB, PubMed, PubMed]; Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure., [RefSeq, PubMed]; Identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2, [RefSeq, PubMed]; MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS., [RefSeq, PubMed]; This provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activation in amyotrophic lateral sclerosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFU4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0097546 ciliary base", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WVS4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63239-1", "uniprot_id": [ { "id": "NEC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63239", "type": "external" } ], "mass": 84174.0, "length": 753, "protein_name": "Neuroendocrine convertase 1", "gene_name": "Pcsk1", "organism": "Mouse", "refseq_name": "neuroendocrine convertase 1 precursor", "refseq_ac": [ { "id": "NP_038656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038656", "type": "external" } ], "gene_names_uniprotkb": "Pcsk1; Att-1; Nec-1; Nec1", "gene_names_refseq": "Nec-1; Nec1; PC1; PC3; Pcsk1; Phpp-1; SPC3", "protein_names_uniprotkb": "Neuroendocrine convertase 1; 3.4.21.93; Furin homolog; NEC 1; PC1; PC3; Prohormone convertase 1; Propeptide-processing protease; Proprotein convertase 1", "protein_names_refseq": "furin homolog; neuroendocrine convertase 1 precursor; neuroendocrine convertase 1; prohormone convertase 1/3; prohormone convertase 1; propeptide-processing protease", "tax_id": 10090, "disease": "proprotein convertase 1/3 deficiency (Disease Ontology:DOID:0111698); hypothyroidism (Disease Ontology:DOID:1459); islet cell tumor (Disease Ontology:DOID:1799); endocrine system disease (Disease Ontology:DOID:28); hyperglycemia (Disease Ontology:DOID:4195); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18548); (R-MMU-209952); (R-MMU-422085)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12095256;16384863;1657897;1862107;2017186;2169760;21750661;25428506;34203471;35900711;8449925", "class_list": "", "function": "Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, oxytocin, vasopressin, enkephalin, dynorphin, somatostatin, insulin and AGRP., [UniProtKB, PubMed]; Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P21662;P22546", "ec_number_list": [ { "id": "3.4.21.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.94", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93", "type": "external" }, { "id": "3.4.17.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.10", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0030141 secretory granule;GO:0030425 dendrite", "go_biological_process": "GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0050714 positive regulation of protein secretion;GO:0016540 protein autoprocessing;GO:0043043 peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P63239-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQE1-1", "uniprot_id": [ { "id": "NPS3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQE1", "type": "external" } ], "mass": 28308.0, "length": 247, "protein_name": "Protein NipSnap homolog 3B", "gene_name": "Nipsnap3b", "organism": "Mouse", "refseq_name": "protein NipSnap homolog 3B isoform 1", "refseq_ac": [ { "id": "NP_079899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079899", "type": "external" } ], "gene_names_uniprotkb": "Nipsnap3b; Nipsnap3a", "gene_names_refseq": "2700063N13Rik; Nipsnap3a; Nipsnap3b", "protein_names_uniprotkb": "Protein NipSnap homolog 3B; NipSnap-related protein; NipSnap3A; NipSnap3B; Protein NipSnap homolog 3A", "protein_names_refseq": "NIPSNAP-related protein; nipsnap homolog 3A; protein NipSnap homolog 3A; protein NipSnap homolog 3B isoform 1; protein NipSnap homolog 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66536)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23806337;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AWZ4;Q8VHX9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z24-1", "uniprot_id": [ { "id": "NEGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Z24", "type": "external" } ], "mass": 37900.0, "length": 348, "protein_name": "Neuronal growth regulator 1", "gene_name": "Negr1", "organism": "Mouse", "refseq_name": "neuronal growth regulator 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001034183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034183", "type": "external" } ], "gene_names_uniprotkb": "Negr1; Kiaa3001; Ntra", "gene_names_refseq": "5330422G01Rik; KILON; Negr1; Ntra", "protein_names_uniprotkb": "Neuronal growth regulator 1; Kilon; Kindred of IgLON; Neurotractin", "protein_names_refseq": "kindred of IgLON; neuronal growth regulator 1 isoform a precursor; neurotractin", "tax_id": 10090, "disease": "", "pathway": " (mmu:320840); (R-MMU-163125)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15946856;18034455;21750661;30899004;33300544", "class_list": "", "function": "May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHQ8;Q80T70", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:0060538 skeletal muscle organ development;GO:0007626 locomotory behavior;GO:0010976 positive regulation of neuron projection development;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80Z24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70414-1", "uniprot_id": [ { "id": "NAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70414", "type": "external" } ], "mass": 108035.0, "length": 970, "protein_name": "Sodium/calcium exchanger 1", "gene_name": "Slc8a1", "organism": "Mouse", "refseq_name": "sodium/calcium exchanger 1 isoform A precursor", "refseq_ac": [ { "id": "NP_035536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035536", "type": "external" } ], "gene_names_uniprotkb": "Slc8a1; Ncx", "gene_names_refseq": "D930008O12Rik; Ncx1; Slc8a1", "protein_names_uniprotkb": "Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 1; Na/Ca exchanger; sodium/calcium exchanger 1 isoform A precursor; sodium/calcium exchanger 1; solute carrier family 8 member 1", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:20541); (R-MMU-418359); (R-MMU-425561); (R-MMU-5578775)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10967099;12781968;21183079;21750661;23506867;25428506;27802388;30084848;31219806;34428180;38714663;8659820", "class_list": "", "function": "Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8659820). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:8659820). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:8659820). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:10967099). Required for normal embryonic heart development and the onset of heart contractions (PubMed:10967099)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70414-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55125-1", "uniprot_id": [ { "id": "NIPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55125", "type": "external" } ], "mass": 33363.0, "length": 284, "protein_name": "Protein NipSnap homolog 1", "gene_name": "Nipsnap1", "organism": "Mouse", "refseq_name": "protein NipSnap homolog 1", "refseq_ac": [ { "id": "NP_032724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032724", "type": "external" } ], "gene_names_uniprotkb": "Nipsnap1", "gene_names_refseq": "Nipsnap1", "protein_names_uniprotkb": "Protein NipSnap homolog 1; NipSnap1", "protein_names_refseq": "4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1; protein NipSnap homolog 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:18082)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20497468;21750661;22311985;23576753;23806337;30982665;33300544;34428180;37453647;9661659", "class_list": "", "function": "Data suggest that amyloid precursor proteins may affect mitochondrial function through a direct interaction with NIPSNAP1 as well as with other mitochondrial proteins., [RefSeq, PubMed]; NIPSNAP1 is an interacting molecule of NST and plays a crucial role in pain transmission., [RefSeq, PubMed]; Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0016020 membrane;GO:0097060 synaptic membrane", "go_biological_process": "GO:0019233 sensory perception of pain;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O55125-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01705-1", "uniprot_id": [ { "id": "NOTC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01705", "type": "external" } ], "mass": 270835.0, "length": 2531, "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "Notch1", "organism": "Mouse", "refseq_name": "neurogenic locus notch homolog protein 1 precursor", "refseq_ac": [ { "id": "NP_032740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032740", "type": "external" } ], "gene_names_uniprotkb": "Notch1; Motch", "gene_names_refseq": "9930111A19Rik; Mis6; N1; Notch1; Tan1; lin-12", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 1; Motch A; Notch 1; mT14; p300", "protein_names_refseq": "Motch A; Notch gene homolog 1; mT14; major type A protein; neurogenic locus notch homolog protein 1 precursor; neurogenic locus notch homolog protein 1; p300", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); aortic valve disease 1 (Disease Ontology:DOID:0080333); intestinal cancer (Disease Ontology:DOID:10155); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); brain cancer (Disease Ontology:DOID:1319); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); hemangiopericytoma (Disease Ontology:DOID:264); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); cholangiocarcinoma (Disease Ontology:DOID:4947); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18128); (R-MMU-1912420); (R-MMU-2122947); (R-MMU-2122948); (R-MMU-350054); (R-MMU-8941856)", "pathway_count": 6, "publication_count": 63, "publication_id_list": "10.1101/2023.09.13.557529;10437788;10882062;10882063;11226752;11459941;11465105;11518718;12050162;12123574;12807718;1425352;1426644;15019995;15240571;15802643;15965470;17573339;18299578;18430783;18628966;21183079;21464124;21750661;21757702;22310717;22645316;22778262;23160044;23615612;23886940;24573683;24730386;25038227;26192747;26495903;27281612;27802388;28011936;28089369;28395734;28498977;30016717;30018219;30127001;32782141;32848054;33725478;33789105;34428180;35290457;35820727;36210013;37838775;38359610;38474544;40885482;7956822;8440332;8449489;8486742;9384671;9653148", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 39, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 50, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 50, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 22, "glyco_site_count": 60, "binding_glycan_count": 0, "secondary_ac_list": "Q06007;Q3TZW2;Q3U3Y2;Q61905;Q7TQ50;Q7TQ51;Q7TQ52;Q8K428;Q99JC2;Q9QW58;Q9R0X7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004857 enzyme inhibitor activity;GO:0004888 transmembrane signaling receptor activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0046579 positive regulation of Ras protein signal transduction;GO:0002051 osteoblast fate commitment;GO:0001708 cell fate specification;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 12.4, "record_id": "Q01705-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A037-1", "uniprot_id": [ { "id": "N4BP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A037", "type": "external" } ], "mass": 99147.0, "length": 893, "protein_name": "NEDD4-binding protein 1", "gene_name": "N4bp1", "organism": "Mouse", "refseq_name": "NEDD4-binding protein 1", "refseq_ac": [ { "id": "NP_085040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085040", "type": "external" } ], "gene_names_uniprotkb": "N4bp1; Kiaa0615", "gene_names_refseq": "N4bp1", "protein_names_uniprotkb": "NEDD4-binding protein 1; 3.1.-.-; N4BP1", "protein_names_refseq": "NEDD4-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80750); (R-MMU-9758274)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11717310;17592138;20233849;21183079;25428506;30084848;30779550;31219806;31599954;32971525;33990547;37807845;38697117", "class_list": "", "function": "May have a role in regulating tumor progression and the response of cancer cells to chemotherapy., [RefSeq, PubMed]; N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB kinase family to limit Toll-like receptor signaling and inflammation., [RefSeq, PubMed]; N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development., [RefSeq, PubMed]; Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation (PubMed:32971525). Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (PubMed:32971525). In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (PubMed:32971525). Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (PubMed:17592138)., [UniProtKB, UniProtKB, PubMed, PubMed]; The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCI4;Q3UH87;Q3UY69", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016787 hydrolase activity;GO:0004540 RNA nuclease activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0045087 innate immune response;GO:0045071 negative regulation of viral genome replication;GO:0031397 negative regulation of protein ubiquitination;GO:0034644 cellular response to UV;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6A037-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE10-1", "uniprot_id": [ { "id": "NAA40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE10", "type": "external" } ], "mass": 27229.0, "length": 237, "protein_name": "N-alpha-acetyltransferase 40", "gene_name": "Naa40", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 40", "refseq_ac": [ { "id": "NP_081919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081919", "type": "external" } ], "gene_names_uniprotkb": "Naa40; Nat11; Patt1", "gene_names_refseq": "4931433E08Rik; Naa40; Nat11; NatD", "protein_names_uniprotkb": "N-alpha-acetyltransferase 40; 2.3.1.257; N-acetyltransferase 11; N-alpha-acetyltransferase D; NatD; Protein acetyltransferase 1", "protein_names_refseq": "N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog; N-acetyltransferase 11; N-alpha-acetyltransferase 40; N-alpha-acetyltransferase D; Nalpha acetyltransferase 40; natD catalytic subunit; protein acetyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70999)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22231784;28528544;35057804;36210013", "class_list": "", "function": "Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism (PubMed:22231784)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3R7;Q6PE89;Q9D4I5", "ec_number_list": [ { "id": "2.3.1.257", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.257", "type": "external" } ], "go_molecular_function": "GO:0010485 histone H4 acetyltransferase activity;GO:0043998 histone H2A acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034451 centriolar satellite;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VE10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPT4-1", "uniprot_id": [ { "id": "MYDGF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPT4", "type": "external" } ], "mass": 17982.0, "length": 166, "protein_name": "Myeloid-derived growth factor", "gene_name": "Mydgf", "organism": "Mouse", "refseq_name": "myeloid-derived growth factor precursor", "refseq_ac": [ { "id": "NP_543027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543027", "type": "external" } ], "gene_names_uniprotkb": "Mydgf; D17Wsu104e", "gene_names_refseq": "D17Wsu104e; Il25; Ly6elg; Mydgf", "protein_names_uniprotkb": "Myeloid-derived growth factor; MYDGF", "protein_names_refseq": "UPF0556 protein C19orf10 homolog; myeloid-derived growth factor precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:28106)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11714798;15378209;25581518;26740625;37767706;39170023", "class_list": "", "function": "Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway., [UniProtKB, PubMed]; Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis., [RefSeq, PubMed]; The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]., [RefSeq]; [Loss of Myeloid-Derived Growth Factor Leads to Increased Fibrosis in Mice After Myocardial Infarction]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSI7;Q3UG74", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CPT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV84-1", "uniprot_id": [ { "id": "NDKD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV84", "type": "external" } ], "mass": 20549.0, "length": 186, "protein_name": "Nucleoside diphosphate kinase D, mitochondrial", "gene_name": "Nme4", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase D, mitochondrial precursor", "refseq_ac": [ { "id": "NP_062705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062705", "type": "external" } ], "gene_names_uniprotkb": "Nme4", "gene_names_refseq": "2610027N22Rik; 2810024O08Rik; 5730493H09Rik; NDK4; NDK; NDPK-D; NDPKD; NM23-M4; Nm23M4; Nme4", "protein_names_uniprotkb": "Nucleoside diphosphate kinase D, mitochondrial; 2.7.4.6; NDK4; NDPK-D; Nucleoside diphosphate kinase 4; nm23-M4", "protein_names_refseq": "NDP kinase, mitochondrial; expressed in non-metastatic cells 4, protein; non-metastatic cells 4, protein expressed in; nucleoside diphosphate kinase 4; nucleoside diphosphate kinase D, mitochondrial precursor; nucleoside diphosphate kinase D, mitochondrial; nucleoside diphosphate kinase D; nucleoside diphosphate kinase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:56520); (R-MMU-499943)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12383506;16476741;21750661;28528544;34344832;34674701;38177901", "class_list": "", "function": "A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondria-specific nucleoside diphosphate kinase that catalyzes the transfer of a gamma-phosphoryl group from ATP to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, participating in nucleoside triphosphate homeostasis (By similarity). In vitro, purine nucleoside triphosphates are much more effective as donors and acceptors than pyrimidine nucleoside triphosphates, and ribonucleosides derivatives are superior to their deoxyribonucleosides counterparts (By similarity). Associates with cardiolipin-containing mitochondrial inner membrane and locally produces ADP in the mitochondrial intermembrane space, which is directly taken up via the ADP/ATP translocase (ANT) into the matrix to stimulate respiratory ATP regeneration. Also directly provides GTP for mitochondrial GTPases, such as the dynamin-related GTPase OPA1. Additionally, catalyzes the anionic phospholipid transfer, namely cardiolipin, from the mitochondrial inner membrane (IM) to the outer membrane (OM) through the formation of contact sites between IM and OM, in a nucleoside diphosphate kinase-independent manner. The switch between the nucleoside diphosphate kinase and the phospholipid transfer activity may depend on the availability and accessibility of cardiolipin and other anionic phospholipids in the IM outer leaflet and OM inner leaflet (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression., [RefSeq, PubMed]; The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006869 lipid transport;GO:0034214 protein hexamerization;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process;GO:0006241 CTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WV84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPL2-1", "uniprot_id": [ { "id": "PHF12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPL2", "type": "external" } ], "mass": 109509.0, "length": 1003, "protein_name": "PHD finger protein 12", "gene_name": "Phf12", "organism": "Mouse", "refseq_name": "PHD finger protein 12", "refseq_ac": [ { "id": "NP_777277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777277", "type": "external" } ], "gene_names_uniprotkb": "Phf12; Kiaa1523", "gene_names_refseq": "2410142K10Rik; F630045O13; PF1; Phf12; mKIAA1523", "protein_names_uniprotkb": "PHD finger protein 12; PHD factor 1; Pf1", "protein_names_refseq": "PHD factor 1; PHD finger protein 12; PHD zinc finger transcription factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:268448)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11390640;17242355;20173027;21183079;21750661;22872234;25428506;27956701;30084848;30779550;34428180;34887587;36852467;40885482", "class_list": "", "function": "These data reveal an unsuspected function for the Pf1-associated chromatin complex in the ribosomal biogenesis and senescence pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail. SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules. SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (By similarity). May also play a role in ribosomal biogenesis (PubMed:27956701)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5SPL3;Q6ZPN8;Q80W50", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0035091 phosphatidylinositol binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0070822 Sin3-type complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q5SPL2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFZ1-1", "uniprot_id": [ { "id": "TECRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFZ1", "type": "external" } ], "mass": 41893.0, "length": 361, "protein_name": "Trans-2,3-enoyl-CoA reductase-like", "gene_name": "Tecrl", "organism": "Mouse", "refseq_name": "trans-2,3-enoyl-CoA reductase-like", "refseq_ac": [ { "id": "NP_722496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722496", "type": "external" } ], "gene_names_uniprotkb": "Tecrl; Srd5a2l2", "gene_names_refseq": "D330017N19Rik; Srd5a2l2; Tecrl", "protein_names_uniprotkb": "Trans-2,3-enoyl-CoA reductase-like; 1.3.1.-; Steroid 5-alpha-reductase 2-like 2 protein", "protein_names_refseq": "steroid 5 alpha-reductase 2-like 2; steroid 5-alpha-reductase 2-like 2 protein; synaptic glycoprotein SC2-like; trans-2,3-enoyl-CoA reductase-like", "tax_id": 10090, "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); catecholaminergic polymorphic ventricular tachycardia 3 (Disease Ontology:DOID:0060677)", "pathway": " (mmu:243078); (R-MMU-75876)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;27861123;35577932;38753506", "class_list": "", "function": "Deletion of TECRL promotes skeletal muscle repair by up-regulating EGR2., [RefSeq, PubMed]; TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIX3", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "1.3.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.93", "type": "external" } ], "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BFZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1E6-1", "uniprot_id": [ { "id": "TBCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1E6", "type": "external" } ], "mass": 27386.0, "length": 244, "protein_name": "Tubulin-folding cofactor B", "gene_name": "Tbcb", "organism": "Mouse", "refseq_name": "tubulin-folding cofactor B isoform 1", "refseq_ac": [ { "id": "NP_079824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079824", "type": "external" } ], "gene_names_uniprotkb": "Tbcb; Ckap1", "gene_names_refseq": "2410007D12Rik; CG22; CKAPI; Ckap1; Tbcb", "protein_names_uniprotkb": "Tubulin-folding cofactor B; Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B", "protein_names_refseq": "cytoskeleton-associated protein 1; cytoskeleton-associated protein CKAPI; tubulin-folding cofactor B isoform 1; tubulin-specific chaperone B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66411)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17184771;17217416;17947660;21183079;22777741", "class_list": "", "function": "Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation (PubMed:17184771). May function as a negative regulator of axonal growth (PubMed:17217416)., [UniProtKB, UniProtKB, PubMed, PubMed]; Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex., [RefSeq, PubMed]; We show that TBCB overexpression depolymerizes microtubules. We found that this function is based on the ability of TBCB to form a binary complex with TBCE that greatly enhances the efficiency of this cofactor to dissociate tubulin in vivo and in vitro., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWR6;Q9DCZ6", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007021 tubulin complex assembly;GO:0031122 cytoplasmic microtubule organization;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D1E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70372-1", "uniprot_id": [ { "id": "TERT_MOUSE", "url": "https://www.uniprot.org/uniprot/O70372", "type": "external" } ], "mass": 127978.0, "length": 1122, "protein_name": "Telomerase reverse transcriptase", "gene_name": "Tert", "organism": "Mouse", "refseq_name": "telomerase reverse transcriptase isoform 1", "refseq_ac": [ { "id": "NP_033380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033380", "type": "external" } ], "gene_names_uniprotkb": "Tert", "gene_names_refseq": "EST2; TCS1; TP2; TRT; TR; Tert", "protein_names_uniprotkb": "Telomerase reverse transcriptase; 2.7.7.49; Telomerase catalytic subunit", "protein_names_refseq": "telomerase catalytic subunit; telomerase reverse transcriptase beta; telomerase reverse transcriptase isoform 1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal dominant dyskeratosis congenita 2 (Disease Ontology:DOID:0070016); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); beta thalassemia (Disease Ontology:DOID:12241); aplastic anemia (Disease Ontology:DOID:12449); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); chronic kidney disease (Disease Ontology:DOID:784); chronic myeloid leukemia (Disease Ontology:DOID:8552); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); plasma cell leukemia (Disease Ontology:DOID:9513); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21752); (R-MMU-171319); (R-MMU-174430); (R-MMU-201722)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "13679242;17130244;19047167;19487455;19571879;21750661;30084848;30779550;34203471;38908367;39329419;9582020;9724727", "class_list": "glycogene", "function": "TERT activation targets DNA methylation and multiple aging hallmarks., [RefSeq, PubMed]; TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential., [RefSeq, PubMed]; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 78, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35432;Q9JK99", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0003968 RNA-directed RNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0071897 DNA biosynthetic process;GO:2000648 positive regulation of stem cell proliferation;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70372-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q7-1", "uniprot_id": [ { "id": "TEBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q7", "type": "external" } ], "mass": 18721.0, "length": 160, "protein_name": "Prostaglandin E synthase 3", "gene_name": "Ptges3", "organism": "Mouse", "refseq_name": "prostaglandin E synthase 3", "refseq_ac": [ { "id": "NP_062740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062740", "type": "external" } ], "gene_names_uniprotkb": "Ptges3; Sid3177; Tebp", "gene_names_refseq": "5730442A20Rik; Ptges3; Ptges; Tebp; cPGES; p23; sid3177", "protein_names_uniprotkb": "Prostaglandin E synthase 3; 5.3.99.3; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; Progesterone receptor complex p23; Sid 3177; Telomerase-binding protein p23; cPGES", "protein_names_refseq": "cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; p23 cochaperone; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; sid 3177; telomerase binding protein, p23", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); oligodendroglioma (Disease Ontology:DOID:3181)", "pathway": " (mmu:56351); (R-MMU-2162123); (R-MMU-3371497); (R-MMU-3371511); (R-MMU-3371568); (R-MMU-8937144); (R-MMU-8939211); (R-MMU-9018519)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "14563409;15345747;15378723;17242355;18630941;19144319;21183079;21750661;22645316;23022695;23806337;25428506;25605945;27281784;28135057;28650975;30084848;31599954;34428180;37453647", "class_list": "", "function": "Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity., [RefSeq, PubMed]; Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23; the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90-p23 client protein, we investigated glucocorticoid signaling. Publication Status: Online-Only, [RefSeq, PubMed]; We report the generation of transgenic mouse lines that overexpress wild-type p23 or uncleavable p23, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542V4;Q9D7V0;Q9WV83", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0070182 DNA polymerase binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008283 cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0051402 neuron apoptotic process;GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway;GO:0032212 positive regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9R0Q7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHK6-1", "uniprot_id": [ { "id": "TEN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHK6", "type": "external" } ], "mass": 308425.0, "length": 2771, "protein_name": "Teneurin-4", "gene_name": "Tenm4", "organism": "Mouse", "refseq_name": "teneurin-4 isoform 1", "refseq_ac": [ { "id": "NP_001297689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297689", "type": "external" } ], "gene_names_uniprotkb": "Tenm4; Doc4; Kiaa1302; Odz4; Tnm4", "gene_names_refseq": "Doc4; ELM2; Odz4; Ten-m4; Tenm4; l(7)-3Rn; l7Rn3; mKIAA1302", "protein_names_uniprotkb": "Teneurin-4; Downstream of CHOP4; Protein Odd Oz/ten-m homolog 4; Ten-4; Ten-m4; Tenascin-M4; Teneurin transmembrane protein 4", "protein_names_refseq": "downstream of CHOP4; odd Oz/ten-m homolog 4; protein Odd Oz/ten-m homolog 4; ten-4; tenascin-M4; teneurin-4 isoform 1; teneurin-4", "tax_id": 10090, "disease": "essential tremor 5 (Disease Ontology:DOID:0111432)", "pathway": " (mmu:23966)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10225957;12000766;12915301;15489520;19349973;21183079;21750661;22872234;22915103;25428506;30084848;33300544;34105348;34203471;34428180;35820727;40885482;9649432", "class_list": "", "function": "Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O70465;Q3TSI0;Q3UH52;Q80TF5;Q9WTS7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0060912 cardiac cell fate specification;GO:0007165 signal transduction;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0001702 gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q3UHK6-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5VCS6-1", "uniprot_id": [ { "id": "TDRD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5VCS6", "type": "external" } ], "mass": 116016.0, "length": 1040, "protein_name": "Tudor domain-containing protein 5", "gene_name": "Tdrd5", "organism": "Mouse", "refseq_name": "tudor domain-containing protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001128213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128213", "type": "external" } ], "gene_names_uniprotkb": "Tdrd5; Gm103", "gene_names_refseq": "Gm103; Tdrd5", "protein_names_uniprotkb": "Tudor domain-containing protein 5", "protein_names_refseq": "tudor domain containing protein 5; tudor domain-containing protein 5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214575)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15465492;21183079;21383078;21750661;29317670;29733347", "class_list": "", "function": "By conditional inactivation of Tdrd5 in postnatal male germ cells (Tdrd5cKO), we show that spermatogenesis is arrested at the round spermatid stage, and the testes of Tdrd5cKO mice are about half the weight of wildtype controls., [RefSeq, PubMed]; Conditional inactivation of TDRD5 in mouse postnatal germ cells reveals that TDRD5 selectively regulates the production of pachytene piRNAs from abundant piRNA-producing precursors, with little effect on low-abundant piRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly., [UniProtKB, PubMed]; TDRD5 is a novel component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis., [RefSeq, PubMed]; Tdrd5 expression is restricted to the male germline throughout development to adulthood, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YQ76;D3YXM4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0071546 pi-body;GO:0033391 chromatoid body;GO:0005737 cytoplasm", "go_biological_process": "GO:0030719 P granule organization;GO:0007286 spermatid development;GO:0141196 transposable element silencing by piRNA-mediated DNA methylation;GO:0030154 cell differentiation;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5VCS6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3J4-1", "uniprot_id": [ { "id": "MTEF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3J4", "type": "external" } ], "mass": 47357.0, "length": 412, "protein_name": "Transcription termination factor 3, mitochondrial", "gene_name": "Mterf3", "organism": "Mouse", "refseq_name": "transcription termination factor 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079823", "type": "external" } ], "gene_names_uniprotkb": "Mterf3; Mterfd1", "gene_names_refseq": "2410017I18Rik; Mterf3; Mterfd1", "protein_names_uniprotkb": "Transcription termination factor 3, mitochondrial; Mitochondrial transcription termination factor 3; mTERF domain-containing protein 1, mitochondrial; mTERF3", "protein_names_refseq": "MTERF domain containing 1; mTERF domain-containing protein 1, mitochondrial; transcription termination factor 3, mitochondrial precursor; transcription termination factor 3, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66410); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17662942;21750661;23300484;34428180", "class_list": "", "function": "Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes (PubMed:17662942, PubMed:23300484). Required for normal mitochondrial function (PubMed:17662942, PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:17662942, PubMed:23300484)., [UniProtKB, UniProtKB, PubMed, PubMed]; MTERF3 is the first example of a mitochondrial protein that acts as a specific repressor of mammalian mtDNA transcription initiation in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSV1;Q9CWM7", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0061668 mitochondrial ribosome assembly;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R3J4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU31-1", "uniprot_id": [ { "id": "ICEF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU31", "type": "external" } ], "mass": 45812.0, "length": 406, "protein_name": "Interactor protein for cytohesin exchange factors 1", "gene_name": "Ipcef1", "organism": "Mouse", "refseq_name": "interactor protein for cytohesin exchange factors 1 isoform 1", "refseq_ac": [ { "id": "NP_001164271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164271", "type": "external" } ], "gene_names_uniprotkb": "Ipcef1; Kiaa0403", "gene_names_refseq": "A130090K04Rik; Ipcef1", "protein_names_uniprotkb": "Interactor protein for cytohesin exchange factors 1", "protein_names_refseq": "interactor protein for cytohesin exchange factors 1 isoform 1; interactor protein for cytohesin exchange factors 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320495)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30016717;34192530;34428180", "class_list": "", "function": "Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner., [UniProtKB]; Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZY2;Q8CAP9", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007167 enzyme-linked receptor protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5DU31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWW1-1", "uniprot_id": [ { "id": "HOME2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWW1", "type": "external" } ], "mass": 40570.0, "length": 354, "protein_name": "Homer protein homolog 2", "gene_name": "Homer2", "organism": "Mouse", "refseq_name": "homer protein homolog 2 isoform 2", "refseq_ac": [ { "id": "NP_001157558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157558", "type": "external" } ], "gene_names_uniprotkb": "Homer2; Vesl2", "gene_names_refseq": "9330120H11Rik; CPD; Homer2; Vesl-2", "protein_names_uniprotkb": "Homer protein homolog 2; Cupidin; Homer-2; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2", "protein_names_refseq": "VASP/Ena-related gene up-regulated during seizure and LTP 2; cupidin; homer homolog 2; homer protein homolog 2 isoform 2; homer protein homolog 2; homer, neuronal immediate early gene, 2; homer-2", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 68 (Disease Ontology:DOID:0110589); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328); muscular atrophy (Disease Ontology:DOID:767); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:26557); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11491285;12860966;21750661;25816005;35008503;9808458;9808459", "class_list": "", "function": "Homer2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities., [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, PubMed, UniProtKB]; Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O89025;Q9Z0E4", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0032703 negative regulation of interleukin-2 production;GO:0019722 calcium-mediated signaling;GO:0042220 response to cocaine;GO:0048148 behavioral response to cocaine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QWW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZP6-1", "uniprot_id": [ { "id": "NFIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZP6", "type": "external" } ], "mass": 33638.0, "length": 311, "protein_name": "NEDD4 family-interacting protein 2", "gene_name": "Ndfip2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndfip2; Kiaa1165; N4wbp5A", "gene_names_refseq": "", "protein_names_uniprotkb": "NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76273)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12050153;15252135;21750661;26495903;27088444;37828378", "class_list": "", "function": "Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (By similarity). May modulate EGFR signaling (By similarity). Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (PubMed:27088444)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTZ9;Q6IR02;Q8BVC5", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007034 vacuolar transport;GO:0010629 negative regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91ZP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97434-1", "uniprot_id": [ { "id": "MPRIP_MOUSE", "url": "https://www.uniprot.org/uniprot/P97434", "type": "external" } ], "mass": 116408.0, "length": 1024, "protein_name": "Myosin phosphatase Rho-interacting protein", "gene_name": "Mprip", "organism": "Mouse", "refseq_name": "myosin phosphatase Rho-interacting protein isoform 2", "refseq_ac": [ { "id": "NP_036157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036157", "type": "external" } ], "gene_names_uniprotkb": "Mprip; Kiaa0864; Mrip; Rhoip3", "gene_names_refseq": "9530046C02; Gm34094; Mprip; RIP3; Rhoip3; mKIAA0864; p116Rip", "protein_names_uniprotkb": "Myosin phosphatase Rho-interacting protein; RIP3; Rho-interacting protein 3; p116Rip", "protein_names_refseq": "Rho interacting protein 3; Rho-interacting protein 3 (p116RIP) (RIP3); myosin phosphatase Rho-interacting protein isoform 2; p116 Rho interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:26936)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12732640;15469989;16243315;16452087;17242355;19144319;20093627;21183079;21750661;22517741;22645316;22872234;28528544;30031227;31219806;34203471;34428180;34887587;36210013;37310356;40885482;9199174", "class_list": "", "function": "LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein., [RefSeq, PubMed]; P116Rip is an F-actin-binding protein with in vitro bundling activity and in vivo capability of disassembling the actomyosin-based cytoskeleton., [RefSeq, PubMed]; P116Rip oligomerizes via its C-terminal coiled-coil domain and, when overexpressed, inhibits RhoA-induced SRF activation without affecting RhoA-GTP levels., [RefSeq, PubMed]; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBR5;Q3TC85;Q3TRS0;Q3U1Y8;Q3U3E4;Q5SWZ3;Q5SWZ4;Q5SWZ7;Q6P559;Q80YC8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P97434-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRM6-1", "uniprot_id": [ { "id": "MEI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRM6", "type": "external" } ], "mass": 44471.0, "length": 389, "protein_name": "Meiosis-specific protein MEI4", "gene_name": "Mei4", "organism": "Mouse", "refseq_name": "meiosis-specific protein MEI4 isoform 1", "refseq_ac": [ { "id": "NP_780422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780422", "type": "external" } ], "gene_names_uniprotkb": "Mei4", "gene_names_refseq": "4930486G11Rik; Mei4", "protein_names_uniprotkb": "Meiosis-specific protein MEI4", "protein_names_refseq": "UPF0623 protein; meiosis-specific protein MEI4 isoform 1; meiosis-specific protein MEI4; meiosis-specific, MEI4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75033)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20551173;21750661;25795304;27723721;30569039;37431931;38252283", "class_list": "", "function": "Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility., [RefSeq, PubMed]; Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation., [RefSeq, PubMed]; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:25795304, PubMed:27723721). Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721)., [UniProtKB, PubMed, PubMed, PubMed]; The association of MEI4 to chromosome axes is required for DNA double-strand break formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Z7;Q8C4E8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome;GO:0000800 lateral element", "go_biological_process": "GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis;GO:0042138 meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BRM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NWV3-1", "uniprot_id": [ { "id": "IF122_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NWV3", "type": "external" } ], "mass": 134798.0, "length": 1182, "protein_name": "Intraflagellar transport protein 122 homolog", "gene_name": "Ift122", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 122 homolog isoform 2", "refseq_ac": [ { "id": "NP_001161235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161235", "type": "external" } ], "gene_names_uniprotkb": "Ift122; Wdr10", "gene_names_refseq": "Ift122; Wdr10; sopb", "protein_names_uniprotkb": "Intraflagellar transport protein 122 homolog; WD repeat-containing protein 10", "protein_names_refseq": "WD repeat domain 10; WD repeat-containing protein 10; intraflagellar transport 122 homolog; intraflagellar transport protein 122 homolog isoform 2; intraflagellar transport protein 122 homolog", "tax_id": 10090, "disease": "cranioectodermal dysplasia 1 (Disease Ontology:DOID:0080803); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:81896); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "19000668;19208653;21209331;21750661;22872234;25428506;30476139;31219806;32152506;34203471;34428180;35820727;36210013", "class_list": "", "function": "As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Studies on a complex A mutant mouse, defective for the Ift122 gene, is reported., [RefSeq, PubMed]; The C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAU2;Q8C8U5;Q8CD77", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0010172 embryonic body morphogenesis;GO:0021513 spinal cord dorsal/ventral patterning;GO:0072594 establishment of protein localization to organelle;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6NWV3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AG06-1", "uniprot_id": [ { "id": "MEIOC_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AG06", "type": "external" } ], "mass": 108830.0, "length": 965, "protein_name": "Meiosis-specific coiled-coil domain-containing protein MEIOC", "gene_name": "Meioc", "organism": "Mouse", "refseq_name": "meiosis-specific coiled-coil domain-containing protein MEIOC", "refseq_ac": [ { "id": "NP_001121048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121048", "type": "external" } ], "gene_names_uniprotkb": "Meioc; Gm1564", "gene_names_refseq": "Gm1564; Gm663; Meioc", "protein_names_uniprotkb": "Meiosis-specific coiled-coil domain-containing protein MEIOC; Meiosis-specific with coiled-coil domain protein", "protein_names_refseq": "meiosis-specific coiled-coil domain-containing protein MEIOC; meiosis-specific with coiled-coil domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:268491)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;26742488;28380054;29033321;36001654", "class_list": "", "function": "Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054)., [UniProtKB, PubMed, PubMed]; Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2K8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AG06-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TRM8-1", "uniprot_id": [ { "id": "HXK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TRM8", "type": "external" } ], "mass": 100101.0, "length": 922, "protein_name": "Hexokinase-3", "gene_name": "Hk3", "organism": "Mouse", "refseq_name": "hexokinase-3 isoform 1", "refseq_ac": [ { "id": "NP_001028417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028417", "type": "external" } ], "gene_names_uniprotkb": "Hk3", "gene_names_refseq": "HK III; HK-III; Hk3", "protein_names_uniprotkb": "Hexokinase-3; 2.7.1.1; HK III; Hexokinase type III; Hexokinase-C", "protein_names_refseq": "hexokinase type III; hexokinase-3 isoform 1; hexokinase-C", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:212032); (R-MMU-6798695); (R-MMU-70171)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;25428506;25904018;31219806;31599954;34428180;35943566;38484574", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels., [RefSeq, PubMed]; Hexokinase expression is highly enriched in neurons compared to astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 59, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAX6;Q3UDP1;Q3UEA4", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0006002 fructose 6-phosphate metabolic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TRM8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCP5-1", "uniprot_id": [ { "id": "MFF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCP5", "type": "external" } ], "mass": 32931.0, "length": 291, "protein_name": "Mitochondrial fission factor", "gene_name": "Mff", "organism": "Mouse", "refseq_name": "mitochondrial fission factor isoform 2", "refseq_ac": [ { "id": "NP_001297624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297624", "type": "external" } ], "gene_names_uniprotkb": "Mff", "gene_names_refseq": "5230400G24Rik; Mff", "protein_names_uniprotkb": "Mitochondrial fission factor", "protein_names_refseq": "mitochondrial fission factor isoform 2", "tax_id": 10090, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 2 (Disease Ontology:DOID:0060994); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:75734)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17208939;17242355;21183079;21750661;23283981;23867156;23921378;30059978;33177519;33476744;35822049;40885482", "class_list": "", "function": "Immunofluorescence analysis of Drp1 suggests that Fis1 and Mff are important for the number and size of Drp1 puncta on mitochondria., [RefSeq, PubMed]; MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. Publication Status: Online-Only, [RefSeq, PubMed]; MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria., [RefSeq, PubMed]; Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids., [RefSeq, PubMed]; Plays a role in mitochondrial and peroxisomal fission (PubMed:23283981, PubMed:30059978). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and mitochondrial fission factor, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT87;Q91VG0;Q9D3P5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion;GO:0007005 mitochondrion organization;GO:0010666 positive regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PCP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K595-1", "uniprot_id": [ { "id": "MCLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K595", "type": "external" } ], "mass": 65450.0, "length": 566, "protein_name": "Mucolipin-2", "gene_name": "Mcoln2", "organism": "Mouse", "refseq_name": "mucolipin-2 isoform 2", "refseq_ac": [ { "id": "NP_001005846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005846", "type": "external" } ], "gene_names_uniprotkb": "Mcoln2", "gene_names_refseq": "3300002C04Rik; Mcoln2; TRPML2", "protein_names_uniprotkb": "Mucolipin-2; TRPML2; Transient receptor potential channel mucolipin 2", "protein_names_refseq": "mucolipidin 2; mucolipin-2 isoform 2; transient receptor potential channel mucolipin 2", "tax_id": 10090, "disease": "mucolipidosis type IV (Disease Ontology:DOID:0080490); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (mmu:68279); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12403827;16137664;16606612;17050035;18794901;19763610;21750661;22753890;26432893;30084848;30479274;34428180", "class_list": "", "function": "Expressed in both B-cell lines and primary B-lymphocytes., [RefSeq, PubMed]; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19763610). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (PubMed:26432893). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel (PubMed:18794901)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Study reveals interesting differences in the regulation and distribution of the members of the TRPML family and identifies a novel role for TRPML2 in the innate immune response., [RefSeq, PubMed]; TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2., [RefSeq, PubMed]; There is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa, [RefSeq, PubMed]; These data provide a direct link between TRPML2 activation, CCL2 release and stimulation of macrophage migration in the innate immune response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCG4;Q8K2T6;Q9CQD3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0005381 iron ion transmembrane transporter activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0055037 recycling endosome;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045087 innate immune response;GO:0032722 positive regulation of chemokine production;GO:0002250 adaptive immune response;GO:0071639 positive regulation of monocyte chemotactic protein-1 production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K595-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42932-1", "uniprot_id": [ { "id": "TCPQ_MOUSE", "url": "https://www.uniprot.org/uniprot/P42932", "type": "external" } ], "mass": 59555.0, "length": 548, "protein_name": "T-complex protein 1 subunit theta", "gene_name": "Cct8", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit theta", "refseq_ac": [ { "id": "NP_033970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033970", "type": "external" } ], "gene_names_uniprotkb": "Cct8; Cctq", "gene_names_refseq": "Cct8; Cctq; Tcpq", "protein_names_uniprotkb": "T-complex protein 1 subunit theta; 3.6.1.-; CCT-theta; TCP-1-theta", "protein_names_refseq": "CCT-theta; T-complex protein 1 subunit theta; TCP-1-theta; chaperonin containing Tcp1, subunit 8 (theta); chaperonin subunit 8 (theta)", "tax_id": 10090, "disease": "", "pathway": " (mmu:12469); (R-MMU-390471); (R-MMU-5620922); (R-MMU-6798695); (R-MMU-6814122)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22645316;23806337;23807208;23872636;24788674;25428506;29187734;30084848;30779550;31219806;34083746;34203471;34428180;34887587;35771867;36210013;37453647;37507081;37828378;39627609;40684658;7890169", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB]; The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0044297 cell body", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P42932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKY8-1", "uniprot_id": [ { "id": "MTEF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKY8", "type": "external" } ], "mass": 43453.0, "length": 385, "protein_name": "Transcription termination factor 2, mitochondrial", "gene_name": "Mterf2", "organism": "Mouse", "refseq_name": "transcription termination factor 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083108", "type": "external" } ], "gene_names_uniprotkb": "Mterf2; Mterfd3", "gene_names_refseq": "1700007D05Rik; Mterf2; Mterfd3", "protein_names_uniprotkb": "Transcription termination factor 2, mitochondrial; Mitochondrial transcription termination factor 2; mTERF domain-containing protein 3, mitochondrial; mTERF2", "protein_names_refseq": "MTERF domain containing 3; mTERF domain-containing protein 3, mitochondrial; transcription termination factor 2, mitochondrial precursor; transcription termination factor 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:74238)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19366608;19490905;21750661", "class_list": "", "function": "Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006393 termination of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BKY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504N7-1", "uniprot_id": [ { "id": "IFIXL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q504N7", "type": "external" } ], "mass": 43825.0, "length": 393, "protein_name": "Pyrin and HIN domain-containing protein 1-like", "gene_name": "Ifi214", "organism": "Mouse", "refseq_name": "pyrin and HIN domain-containing protein 1-like", "refseq_ac": [ { "id": "NP_001019892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019892", "type": "external" } ], "gene_names_uniprotkb": "Ifi214; BC094916", "gene_names_refseq": "Ifi214; Pyhin-B; p214", "protein_names_uniprotkb": "Pyrin and HIN domain-containing protein 1-like; Interferon-inducible protein 214", "protein_names_refseq": "interferon-inducible protein 214; pyrin and HIN domain-containing protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:545384)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "This gene encodes a protein that is a member of the PAAD/DAPIN/Pyrin domain family of proteins. However, compared to the related pyrin and HIN domain family, member 1 (Pyhin1) protein, this protein is C-terminally truncated and lacks a HIN domain, which has an unknown function. It is therefore possible that this gene represents a pseudogene of the Pyhin1 gene, but it is currently being retained as a functional protein-coding gene based on the presence of an intact PAAD/DAPIN/Pyrin domain. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1B4", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q504N7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08784-1", "uniprot_id": [ { "id": "TCOF_MOUSE", "url": "https://www.uniprot.org/uniprot/O08784", "type": "external" } ], "mass": 135001.0, "length": 1320, "protein_name": "Treacle protein", "gene_name": "Tcof1", "organism": "Mouse", "refseq_name": "treacle protein isoform 2", "refseq_ac": [ { "id": "NP_035682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035682", "type": "external" } ], "gene_names_uniprotkb": "Tcof1", "gene_names_refseq": "Tcof1; treacle", "protein_names_uniprotkb": "Treacle protein; Treacher Collins syndrome protein homolog", "protein_names_refseq": "Treacher Collins Franceschetti syndrome 1, homolog; treacher Collins syndrome protein homolog; treacle protein isoform 2", "tax_id": 10090, "disease": "Treacher Collins syndrome 1 (Disease Ontology:DOID:0080789); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (mmu:21453)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;17873058;19131326;19144319;21183079;21750661;22645316;23806337;25428506;25428507;26495903;28528544;29187734;31219806;33725478;34428180;35082403;35820727;35984892;36852467;39237990;9158147;9299440", "class_list": "", "function": "Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification., [UniProtKB, UniProtKB]; Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O08857", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0097110 scaffold protein binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0014029 neural crest formation;GO:0006417 regulation of translation;GO:0014032 neural crest cell development;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O08784-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TB92-1", "uniprot_id": [ { "id": "MILR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TB92", "type": "external" } ], "mass": 27366.0, "length": 246, "protein_name": "Allergin-1", "gene_name": "Milr1", "organism": "Mouse", "refseq_name": "allergin-1 isoform a precursor", "refseq_ac": [ { "id": "NP_001028607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028607", "type": "external" } ], "gene_names_uniprotkb": "Milr1; Gm885; Mca32", "gene_names_refseq": "Allergin-1; Gm885; Mca32; Milr1", "protein_names_uniprotkb": "Allergin-1; Allergy inhibitory receptor 1; MCA-32; Mast cell Ag-32; Mast cell antigen 32; Mast cell immunoglobulin-like receptor 1", "protein_names_refseq": "allergin-1 isoform a precursor; allergy inhibitory receptor 1; mast cell Ag-32; mast cell antigen 32; surface protein MCA-32", "tax_id": 10090, "disease": "", "pathway": " (mmu:380732)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19144319;20526344;21750661;24552759;27932517;31793637;31900344;38442194", "class_list": "", "function": "Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation., [RefSeq, PubMed]; An inhibitory immunoreceptor Allergin-1 regulates the intestinal dysbiosis and barrier function in mice., [RefSeq, PubMed]; Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; It is a immunoglobulin-like receptor which regulates the activation of mast cell.(review) Review article, [RefSeq, PubMed]; Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice., [RefSeq, PubMed]; The results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTB7;B7ZP18;D6RUW9;Q3TC23;Q3TDY5;Q3U5M7;Q3U9F5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0043303 mast cell degranulation;GO:0033004 negative regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TB92-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTX9-1", "uniprot_id": [ { "id": "HSDL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTX9", "type": "external" } ], "mass": 36868.0, "length": 330, "protein_name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "gene_name": "Hsdl1", "organism": "Mouse", "refseq_name": "inactive hydroxysteroid dehydrogenase-like protein 1 isoform a", "refseq_ac": [ { "id": "NP_780394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780394", "type": "external" } ], "gene_names_uniprotkb": "Hsdl1", "gene_names_refseq": "2700067E09Rik; Hsdl1", "protein_names_uniprotkb": "Inactive hydroxysteroid dehydrogenase-like protein 1", "protein_names_refseq": "inactive hydroxysteroid dehydrogenase-like protein 1 isoform a; inactive hydroxysteroid dehydrogenase-like protein 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72552)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22872234;31219806;33300544;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U839", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BTX9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52792-1", "uniprot_id": [ { "id": "HXK4_MOUSE", "url": "https://www.uniprot.org/uniprot/P52792", "type": "external" } ], "mass": 52089.0, "length": 465, "protein_name": "Hexokinase-4", "gene_name": "Gck", "organism": "Mouse", "refseq_name": "hexokinase-4 isoform 2", "refseq_ac": [ { "id": "NP_001274315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274315", "type": "external" } ], "gene_names_uniprotkb": "Gck; Gk", "gene_names_refseq": "GLK; Gck; Gk; Gls006; HK4; HKIV; HXKP; Hlb62; MODY2", "protein_names_uniprotkb": "Hexokinase-4; 2.7.1.1; Glucokinase; HK IV; HK4; Hexokinase type IV; Hexokinase-D", "protein_names_refseq": "HK IV; hexokinase type IV; hexokinase-4 isoform 2; hexokinase-4; hexokinase-D", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); hyperglycemia (Disease Ontology:DOID:4195); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:103988)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10713097;1999433;21750661;21987372;24187134;25428506;27520373;7665557;8530440;8575768;8575769;9867845", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:8530440). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:8530440, PubMed:9867845). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (PubMed:8530440, PubMed:9867845). In pancreas, plays an important role in modulating insulin secretion (PubMed:8530440). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (PubMed:9867845). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:9867845). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52791", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52792-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDM2-1", "uniprot_id": [ { "id": "SRSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDM2", "type": "external" } ], "mass": 27745.0, "length": 248, "protein_name": "Serine/arginine-rich splicing factor 1", "gene_name": "Srsf1", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 1 isoform 2", "refseq_ac": [ { "id": "NP_001071635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071635", "type": "external" } ], "gene_names_uniprotkb": "Srsf1; Sfrs1", "gene_names_refseq": "1110054N12Rik; 5730507C05Rik; 6330415C05Rik; Asf; Sf2; Sfrs1; Srsf1", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 1; ASF/SF2; Pre-mRNA-splicing factor SRp30a; Splicing factor, arginine/serine-rich 1", "protein_names_refseq": "ASF/SF2; pre-mRNA-splicing factor SRp30a; serine/arginine-rich splicing factor 1 isoform 2; serine/arginine-rich splicing factor 1; splicing factor, arginine/serine-rich 1 (ASF/SF2)", "tax_id": 10090, "disease": "neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0070513); stomach cancer (Disease Ontology:DOID:10534); renovascular hypertension (Disease Ontology:DOID:1591); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:110809); (R-MMU-159236); (R-MMU-72163); (R-MMU-72165); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "11925564;15652482;19131326;21750661;22645316;24129315;28785060;34428180;37453647;37907803;38271475;38569495;39069042;9307018", "class_list": "", "function": "Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1, [RefSeq, PubMed]; LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-kappaB axis., [RefSeq, PubMed]; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing (PubMed:28785060). Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing (By similarity). Specifically regulates alternative splicing of cardiac isoforms of CAMK2D, LDB3/CYPHER and TNNT2/CTNT during heart remodeling at the juvenile to adult transition. The inappropriate accumulation of a neonatal and neuronal isoform of CAMKD2 in the adult heart results in aberrant calcium handling and defective excitation-contraction coupling in cardiomyocytes. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (PubMed:15652482)., [UniProtKB, UniProtKB, PubMed, PubMed]; SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing., [RefSeq, PubMed]; SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing. Publication Status: Online-Only, [RefSeq, PubMed]; Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGJ5;Q3UCH2;Q5SXC5;Q8BJV3;Q8C1H9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043422 protein kinase B binding;GO:0044547 DNA topoisomerase binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0001701 in utero embryonic development;GO:0048255 mRNA stabilization;GO:0008380 RNA splicing;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6PDM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U4H6-1", "uniprot_id": [ { "id": "HEXD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U4H6", "type": "external" } ], "mass": 54576.0, "length": 486, "protein_name": "Hexosaminidase D", "gene_name": "Hexd", "organism": "Mouse", "refseq_name": "hexosaminidase D isoform 2", "refseq_ac": [ { "id": "NP_001001333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001333", "type": "external" } ], "gene_names_uniprotkb": "Hexd; Hexdc", "gene_names_refseq": "Hexdc; Hexd", "protein_names_uniprotkb": "Hexosaminidase D; 3.2.1.52; Beta-N-acetylhexosaminidase; Beta-hexosaminidase D; Hexosaminidase domain-containing protein; N-acetyl-beta-galactosaminidase", "protein_names_refseq": "N-acetyl-beta-galactosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase D; hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing; hexosaminidase D isoform 2; hexosaminidase domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:238023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19040401;21750661;21807949;31219806;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Has hexosaminidase activity (PubMed:19040401). Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (By similarity)., [UniProtKB, PubMed, UniProtKB]; Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates., [UniProtKB, UniProtKB, UniProtKB]; Lipid-droplet-targeted isoform is a key regulator of the proteasome, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7UUP4;B7UUP5;Q6NSQ8", "ec_number_list": [], "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U4H6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNT9-1", "uniprot_id": [ { "id": "BICL1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0JNT9", "type": "external" } ], "mass": 65287.0, "length": 577, "protein_name": "BICD family-like cargo adapter 1", "gene_name": "Bicdl1", "organism": "Mouse", "refseq_name": "BICD family-like cargo adapter 1", "refseq_ac": [ { "id": "NP_001074277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074277", "type": "external" } ], "gene_names_uniprotkb": "Bicdl1; Bicdr1; Ccdc64", "gene_names_refseq": "2210403N09Rik; BICDR-1; Bicdl1; Ccdc64", "protein_names_uniprotkb": "BICD family-like cargo adapter 1; BICD-related protein 1; BICDR-1; Bicaudal D-related protein 1; Coiled-coil domain-containing protein 64A", "protein_names_refseq": "BICD family-like cargo adapter 1; BICD-related protein 1; bicaudal D-related protein 1; coiled-coil domain containing 64; coiled-coil domain-containing protein 64A", "tax_id": 10090, "disease": "", "pathway": " (mmu:75665)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20360680;21750661;29420470;33734450;36071160", "class_list": "", "function": "Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:29420470, PubMed:33734450, PubMed:36071160). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; BICDR-1 has an important role as temporal regulator of secretory trafficking during the early phase of neuronal differentiation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9J5;Q8CB56;Q8R1D2", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0031175 neuron projection development;GO:0047496 vesicle transport along microtubule;GO:0055107 Golgi to secretory granule transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0JNT9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFE2-1", "uniprot_id": [ { "id": "HPF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFE2", "type": "external" } ], "mass": 39291.0, "length": 346, "protein_name": "Histone PARylation factor 1", "gene_name": "Hpf1", "organism": "Mouse", "refseq_name": "histone PARylation factor 1 isoform 1", "refseq_ac": [ { "id": "NP_082575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082575", "type": "external" } ], "gene_names_uniprotkb": "Hpf1; 2700029M09Rik", "gene_names_refseq": "2700029M09Rik; C230006B22Rik; C4orf27; Hpf1", "protein_names_uniprotkb": "Histone PARylation factor 1", "protein_names_refseq": "UPF0609 protein C4orf27 homolog; histone PARylation factor 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72612)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23806337;33589610", "class_list": "", "function": "Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1., [UniProtKB, UniProtKB]; HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090734 site of DNA damage;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0071168 protein localization to chromatin;GO:0070212 protein poly-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXG3-1", "uniprot_id": [ { "id": "IFT57_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXG3", "type": "external" } ], "mass": 48772.0, "length": 429, "protein_name": "Intraflagellar transport protein 57 homolog", "gene_name": "Ift57", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 57 homolog", "refseq_ac": [ { "id": "NP_082956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082956", "type": "external" } ], "gene_names_uniprotkb": "Ift57; Hippi", "gene_names_refseq": "4833420A15Rik; Esrrbl1; Hippi; Ift57; MHS4R2", "protein_names_uniprotkb": "Intraflagellar transport protein 57 homolog; HIP1-interacting protein", "protein_names_refseq": "HIP1-interacting protein; Vestrogen-related receptor beta like 1; estrogen-related receptor beta like 1; huntingtin-interacting protein-1 protein interactor; intraflagellar transport 57 homolog; intraflagellar transport protein 57 homolog", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); orofaciodigital syndrome XVIII (Disease Ontology:DOID:0060961)", "pathway": " (mmu:73916); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11062270;11788820;11835052;11916979;12821668;17027958;17107665;17874297;17931679;18188704;19253336;21750661;23810713;25860617;31637240", "class_list": "", "function": "Hip-1 and Hippi cooperate to induce neuronal apoptosis in a caspase-8-dependent manner., [RefSeq, PubMed]; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Together with RAB23 and KIF17, it is required for the localization of specific G protein-coupled receptors, such as dopamime receptor DRD1, to primary cilia (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear., [UniProtKB, PubMed, UniProtKB]; Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924M2;Q9CUS6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0005930 axoneme", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0050680 negative regulation of epithelial cell proliferation;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BXG3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61727-1", "uniprot_id": [ { "id": "I10R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61727", "type": "external" } ], "mass": 64248.0, "length": 575, "protein_name": "Interleukin-10 receptor subunit alpha", "gene_name": "Il10ra", "organism": "Mouse", "refseq_name": "interleukin-10 receptor subunit alpha isoform 1 precursor", "refseq_ac": [ { "id": "NP_032374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032374", "type": "external" } ], "gene_names_uniprotkb": "Il10ra; Il10r", "gene_names_refseq": "CDw210a; CDw210; IL-10R1; IL-10RA; Il10ra; Il10r; mIL-10R", "protein_names_uniprotkb": "Interleukin-10 receptor subunit alpha; CDw210a; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; Interleukin-10 receptor subunit 1", "protein_names_refseq": "IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha isoform 1 precursor; interleukin-10 receptor subunit alpha", "tax_id": 10090, "disease": "inflammatory bowel disease 28 (Disease Ontology:DOID:0110899)", "pathway": " (mmu:16154); (R-MMU-6783783)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;26740625;37828378;8248239;8910398", "class_list": "", "function": "Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019969 interleukin-10 binding;GO:0004920 interleukin-10 receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0010507 negative regulation of autophagy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway;GO:0060729 intestinal epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61727-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46935-1", "uniprot_id": [ { "id": "NEDD4_MOUSE", "url": "https://www.uniprot.org/uniprot/P46935", "type": "external" } ], "mass": 102706.0, "length": 887, "protein_name": "E3 ubiquitin-protein ligase NEDD4", "gene_name": "Nedd4", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NEDD4 isoform 1", "refseq_ac": [ { "id": "NP_035020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035020", "type": "external" } ], "gene_names_uniprotkb": "Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a; Rpf1", "gene_names_refseq": "E430025J12Rik; EG639396; Gm7265; KIAA0093; Nedd4-1; Nedd4a; Nedd4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEDD4; 2.3.2.26; HECT-type E3 ubiquitin transferase NEDD4; NEDD-4; Neural precursor cell expressed developmentally down-regulated protein 4", "protein_names_refseq": "E3 ubiquitin-protein ligase NEDD4 isoform 1; E3 ubiquitin-protein ligase NEDD4; HECT-type E3 ubiquitin transferase NEDD4; neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated gene 4a", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:17999); (R-MMU-1169408); (R-MMU-1253288); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-983168)", "pathway_count": 6, "publication_count": 41, "publication_id_list": "11042109;12697834;1378265;15060076;15908698;16452087;17242355;18286479;19047365;19131326;19193720;20159449;20980250;21183079;21540332;21750661;22517741;22645316;24788674;25153642;25428506;26495903;28528544;28784777;30084848;30779550;31219806;32782141;33300544;34203471;34428180;34887587;35820727;36852467;37507081;37828378;38888282;39627609;40885482;9182527;9407065", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (PubMed:18286479). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates DAZAP2, leading to its proteasomal degradation (By similarity). Ubiquitinates POLR2A (By similarity). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O08758;Q3UZI2;Q8BGB3", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0031698 beta-2 adrenergic receptor binding;GO:0019871 sodium channel inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007528 neuromuscular junction development;GO:0031175 neuron projection development;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P46935-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KNY0-1", "uniprot_id": [ { "id": "IGFN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3KNY0", "type": "external" } ], "mass": 303658.0, "length": 2849, "protein_name": "Immunoglobulin-like and fibronectin type III domain-containing protein 1", "gene_name": "Igfn1", "organism": "Mouse", "refseq_name": "immunoglobulin-like and fibronectin type III domain-containing protein 1", "refseq_ac": [ { "id": "NP_808310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808310", "type": "external" } ], "gene_names_uniprotkb": "Igfn1", "gene_names_refseq": "9830123M21Rik; Igfn1", "protein_names_uniprotkb": "Immunoglobulin-like and fibronectin type III domain-containing protein 1", "protein_names_refseq": "eEF1A2 binding protein; immunoglobulin-like and fibronectin type 3 domain containing 1 protein; immunoglobulin-like and fibronectin type III domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226438)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20206623;21750661;25428506;28665998;34418053", "class_list": "", "function": "Expression of IGFN1_v1 partially rescued fusion and myotube morphology in the Igfn1 exon 13 knock-out cell line, indicating a role for this variant in myoblast fusion and differentiation Publication Status: Online-Only, [RefSeq, PubMed]; KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ74", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0030018 Z disc", "go_biological_process": "GO:0007520 myoblast fusion;GO:0045445 myoblast differentiation;GO:0014902 myotube differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3KNY0-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922G7-1", "uniprot_id": [ { "id": "TEKT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922G7", "type": "external" } ], "mass": 50311.0, "length": 430, "protein_name": "Tektin-2", "gene_name": "Tekt2", "organism": "Mouse", "refseq_name": "tektin-2", "refseq_ac": [ { "id": "NP_036032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036032", "type": "external" } ], "gene_names_uniprotkb": "Tekt2", "gene_names_refseq": "Tekt2; tektin-t", "protein_names_uniprotkb": "Tektin-2; Tektin-t; Testicular tektin", "protein_names_refseq": "tektin-2; testicular tektin", "tax_id": 10090, "disease": "", "pathway": " (mmu:24084)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10456331;15340058;18474621;21750661;24394471;25428506;35547804;36206347;36210013;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Tek2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis., [RefSeq, PubMed]; Tektin-t participates in dynein inner arm formation or attachment and that the loss of Tektin-t results in impaired motility of both flagella and cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVR0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0036126 sperm flagellum;GO:0005814 centriole;GO:0097228 sperm principal piece", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q922G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WS2-1", "uniprot_id": [ { "id": "NLRP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WS2", "type": "external" } ], "mass": 97402.0, "length": 869, "protein_name": "NACHT, LRR and PYD domains-containing protein 6", "gene_name": "Nlrp6", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 6", "refseq_ac": [ { "id": "NP_598707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598707", "type": "external" } ], "gene_names_uniprotkb": "Nlrp6; Nalp6; Navr; Pypaf5", "gene_names_refseq": "Avr; Nalp6; Navr/Avr; Navr; Nlrp6; Non-AVR; Pypaf5", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; Non-AVR; Non-angiotensin-vasopressin receptor; PYRIN-containing APAF1-like protein 5-like", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 6; NACHT, leucine rich repeat and PYD containing 6; NACHT/LRR/pyrin domain-containing protein 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; non-angiotensin-vasopressin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:101613)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "11984003;12633874;20923861;21543645;21565393;21593405;21750661;22763455;23470617;23696660;24581500;26253422;26494172;26638072;27339979;28445725;28801232;29281815;29281837;30084848;30248149;30392956;31219806;32424362;33230225;33372132;33617596;33918100;34678144;38720893;38968694;7489366;9095083", "class_list": "", "function": "Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 (PubMed:21593405, PubMed:30392956, PubMed:32424362, PubMed:34678144). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30392956). Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) (PubMed:26494172, PubMed:30392956, PubMed:34678144). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome (PubMed:34678144). Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex (PubMed:34678144). The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu (PubMed:30392956). The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine (PubMed:21565393, PubMed:22763455, PubMed:23696660, PubMed:26638072, PubMed:28445725, PubMed:30392956). Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 (PubMed:30392956). Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (PubMed:26494172, PubMed:34678144). Required to prevent infection by the apicomplexan parasite C.tyzzeri in enterocytes by promoting GSDMD-dependent release of IL18 (PubMed:33372132). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (PubMed:21565393, PubMed:22763455, PubMed:26638072, PubMed:33617596). Its role in the regulation of the gut microbiota composition is however subject to discussion (PubMed:28801232, PubMed:29281815, PubMed:29281837). Essential for gut mucosal self-renewal and proliferation (PubMed:21543645, PubMed:21565393, PubMed:21593405). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria (PubMed:24581500, PubMed:27339979). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (PubMed:22763455, PubMed:30248149, PubMed:33230225, PubMed:33918100). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (PubMed:26253422)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NLRP6 negatively regulates host defense against polymicrobial sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model., [RefSeq, PubMed]; The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]., [RefSeq]; The suppressive role of NLRP6 in host defense against Streptococcus suis infection., [RefSeq, PubMed]; This publication deals with the rat ortholog of the mouse Nlrp6 gene., [RefSeq, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9W978;F8UKQ6;Q67EY0;Q8K0L4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003725 double-stranded RNA binding;GO:0042277 peptide binding;GO:0035591 signaling adaptor activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0032741 positive regulation of interleukin-18 production;GO:0010506 regulation of autophagy;GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q91WS2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35951-1", "uniprot_id": [ { "id": "LDLR_MOUSE", "url": "https://www.uniprot.org/uniprot/P35951", "type": "external" } ], "mass": 94947.0, "length": 862, "protein_name": "Low-density lipoprotein receptor", "gene_name": "Ldlr", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001239587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239587", "type": "external" } ], "gene_names_uniprotkb": "Ldlr", "gene_names_refseq": "Hlb301; Ldlr", "protein_names_uniprotkb": "Low-density lipoprotein receptor; LDL receptor", "protein_names_refseq": "LDL receptor; low-density lipoprotein receptor isoform 2 precursor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); migraine without aura (Disease Ontology:DOID:12783); familial hypercholesterolemia (Disease Ontology:DOID:13810); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); xanthomatosis (Disease Ontology:DOID:3345); systemic lupus erythematosus (Disease Ontology:DOID:9074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:16835); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8964026); (R-MMU-8964038)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11247302;11465105;12169628;1475710;21750661;26495903;27802388;28011936;28528544;30084848;34428180;35820727;37828378;39950214;8466528", "class_list": "", "function": "Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTJ9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0001523 retinoid metabolic process;GO:0006629 lipid metabolic process;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35951-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48678-1", "uniprot_id": [ { "id": "LMNA_MOUSE", "url": "https://www.uniprot.org/uniprot/P48678", "type": "external" } ], "mass": 74238.0, "length": 665, "protein_name": "Prelamin-A/C", "gene_name": "Lmna", "organism": "Mouse", "refseq_name": "prelamin-A/C isoform A precursor", "refseq_ac": [ { "id": "NP_001002011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002011", "type": "external" } ], "gene_names_uniprotkb": "Lmna; Lmn1", "gene_names_refseq": "Dhe; Lmna", "protein_names_uniprotkb": "Prelamin-A/C", "protein_names_refseq": "lamin C; lamin-A/C; prelamin-A/C isoform A precursor; prelamin-A/C", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial partial lipodystrophy (Disease Ontology:DOID:0050440); congenital muscular dystrophy (Disease Ontology:DOID:0050557); atrioventricular block (Disease Ontology:DOID:0050820); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); restrictive dermopathy 2 (Disease Ontology:DOID:0070370); aortic valve disease 2 (Disease Ontology:DOID:0080334); mandibuloacral dysplasia type A lipodystrophy (Disease Ontology:DOID:0081128); Charcot-Marie-Tooth disease type 2B1 (Disease Ontology:DOID:0110156); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome (Disease Ontology:DOID:0111584); otitis media (Disease Ontology:DOID:10754); lipoatrophic diabetes mellitus (Disease Ontology:DOID:11712); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); Werner syndrome (Disease Ontology:DOID:5688); muscle tissue disease (Disease Ontology:DOID:66); cerebrovascular disease (Disease Ontology:DOID:6713); lipodystrophy (Disease Ontology:DOID:811); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:16905); (R-MMU-2980766); (R-MMU-2995383); (R-MMU-352238); (R-MMU-4419969)", "pathway_count": 5, "publication_count": 58, "publication_id_list": "10.1101/2023.09.13.557529;10579712;11799477;11929849;16380439;16452087;16648470;17242355;17652517;18230648;18606848;18808171;19124654;19131326;19144319;1959608;19843581;19933576;21183079;21327075;21498514;21540332;21547077;21750661;21982926;22349700;23443134;23535822;23695662;23806337;25428506;2583287;26436652;26495903;2719959;28241138;30016717;30059200;30084848;31219806;31576060;32782141;32848054;34105348;34428180;34887587;35822049;36288343;36852467;37453647;37507081;40021952;40684658;40885482;40997131;7781761;7916626;8187835", "class_list": "", "function": "Isoform C2 may have a role in determining the organization of nuclear and chromosomal structures during spermatogenesis., [UniProtKB, PubMed]; Lamin C2 as a 'natural lamin deletion mutant' that confers unique properties to the nuclear envelope which would be essential for dynamic telomere repositioning during meiotic prophase I, [RefSeq, PubMed]; Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10579712, PubMed:28241138, PubMed:31576060). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10579712, PubMed:28241138). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (By similarity). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:10579712, PubMed:28241138). Lamin A and C are present in equal amounts in the lamina of mammals (By similarity). Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (By similarity). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:11799477, PubMed:19124654, PubMed:23535822). Required for osteoblastogenesis and bone formation (By similarity). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:21547077, PubMed:21982926). Required for cardiac homeostasis (PubMed:26436652)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence., [UniProtKB, UniProtKB]; This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 50, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 29, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "B3RH23;B3RH24;P11516;P97859;Q3TIH0;Q3TTS8;Q3U733;Q3U7I5;Q3UCA0;Q3UCJ8;Q3UCU3;Q91WF2;Q9DC21", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0008157 protein phosphatase 1 binding;GO:0160123 structural constituent of nuclear lamina", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0090435 protein localization to nuclear envelope;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 7.5, "record_id": "P48678-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35942-1", "uniprot_id": [ { "id": "NEK2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35942", "type": "external" } ], "mass": 51243.0, "length": 443, "protein_name": "Serine/threonine-protein kinase Nek2", "gene_name": "Nek2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek2 isoform 1", "refseq_ac": [ { "id": "NP_035022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035022", "type": "external" } ], "gene_names_uniprotkb": "Nek2", "gene_names_refseq": "Nek2", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek2; 2.7.11.1; Never in mitosis A-related kinase 2; NimA-related protein kinase 2", "protein_names_refseq": "NIMA - related expressed kinase 2; NIMA-related expressed kinase 2; NIMA-related kinase 2; Nek2 kinase; never in mitosis A-related kinase 2; nimA-related protein kinase 2; serine/threonine-protein kinase Nek2 isoform 1; serine/threonine-protein kinase Nek2", "tax_id": 10090, "disease": "retinitis pigmentosa 67 (Disease Ontology:DOID:0110359); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18005); (R-MMU-179409); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518); (R-MMU-9929356)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "14668482;14697346;34428180;37348763;38176677;9187143;9434622;9583679", "class_list": "", "function": "Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction., [RefSeq, PubMed]; NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis., [RefSeq, PubMed]; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (By similarity). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (By similarity). Phosphorylates and activates NEK11 in G1/S-arrested cells. Involved in the regulation of centrosome disjunction (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35959;Q3TPD7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UP24-1", "uniprot_id": [ { "id": "NLRC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UP24", "type": "external" } ], "mass": 116749.0, "length": 1024, "protein_name": "NLR family CARD domain-containing protein 4", "gene_name": "Nlrc4", "organism": "Mouse", "refseq_name": "NLR family CARD domain-containing protein 4", "refseq_ac": [ { "id": "NP_001028539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028539", "type": "external" } ], "gene_names_uniprotkb": "Nlrc4; Card12; Ipaf", "gene_names_refseq": "9530011P19Rik; CLAN1; CLANA; CLANB; CLANC; CLAND; CLAN; Card12; IPAF; Nlrc4", "protein_names_uniprotkb": "NLR family CARD domain-containing protein 4; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf", "protein_names_refseq": "NLR family CARD domain-containing protein 4; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; ice protease-activating factor", "tax_id": 10090, "disease": "familial cold autoinflammatory syndrome 4 (Disease Ontology:DOID:0090065)", "pathway": " (mmu:268973)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "15190255;16648852;16648853;16717117;18070936;18250455;19343209;20133635;20603313;21147462;21750661;21874021;21918512;22174673;22231517;22484733;22547706;22885697;23765277;26449474;26585513;29146805;29182158;30084848;34428180;39175123", "class_list": "", "function": "Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association., [RefSeq, PubMed]; Cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways [IPAF], [RefSeq, PubMed]; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAU8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0061133 endopeptidase activator activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q3UP24-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505F1-1", "uniprot_id": [ { "id": "NR2C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q505F1", "type": "external" } ], "mass": 65476.0, "length": 590, "protein_name": "Nuclear receptor subfamily 2 group C member 1", "gene_name": "Nr2c1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 2 group C member 1", "refseq_ac": [ { "id": "NP_035759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035759", "type": "external" } ], "gene_names_uniprotkb": "Nr2c1; Tr2-11; Tr2", "gene_names_refseq": "4831444H07Rik; 80.3; Eenr; Nr2c1; TR2; Tr2-11", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor TR2; Testicular receptor 2; mTR2", "protein_names_refseq": "80-3 cNDA; early embryonic nuclear receptor; mTR2; nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; orphan nuclear receptor TR2; orphan receptor, TR2-11; testicular receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22025); (R-MMU-383280)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "11463856;12052874;12093744;16130175;16317770;17187077;17389641;17431400;17974920;18682553;19131575;19204783;26712358;28551284;30084848;31219806;34428180;8530418;8595902;8858600;9071982;9369481;9504722;9694834;9774688", "class_list": "", "function": "Nr2c1 may be a candidate for mediating parallel adaptive changes in cranial neural sensory specializations such as the olfactory epithelium, retina and mystacial vibrissae and in non-neural craniofacial features including teeth, [RefSeq, PubMed]; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This study supports a role for Nr2c1 in defining the biphasic period of retinal development and specifically influencing the early phase of retinal cell fate. Erratum:[Dev Biol. 2017 Sep 1;429(1):370. doi: 10.1016/j.ydbio.2017.07.009. PMID: 28743516], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97763;Q0VGP8;Q3UIJ7;Q4U1Z4;Q60927;Q62152;Q8VIJ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q505F1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02830-1", "uniprot_id": [ { "id": "HXA7_MOUSE", "url": "https://www.uniprot.org/uniprot/P02830", "type": "external" } ], "mass": 25682.0, "length": 229, "protein_name": "Homeobox protein Hox-A7", "gene_name": "Hoxa7", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A7 isoform 1", "refseq_ac": [ { "id": "NP_034585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034585", "type": "external" } ], "gene_names_uniprotkb": "Hoxa7; Hox-1.1; Hoxa-7", "gene_names_refseq": "Hox-1.1; Hoxa7; M6", "protein_names_uniprotkb": "Homeobox protein Hox-A7; Homeobox protein Hox-1.1; Homeobox protein M6-12; M6", "protein_names_refseq": "HOMEOBOX PROTEIN HOX-A7 (HOX-1.1) (M6-12) (M6); homeobox protein Hox-A7 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15404)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;2877873;2885847;2986010;7890170", "class_list": "glycogene", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RS54;Q544P0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02830-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10637-1", "uniprot_id": [ { "id": "TAU_MOUSE", "url": "https://www.uniprot.org/uniprot/P10637", "type": "external" } ], "mass": 76243.0, "length": 733, "protein_name": "Microtubule-associated protein tau", "gene_name": "Mapt", "organism": "Mouse", "refseq_name": "microtubule-associated protein tau isoform 1", "refseq_ac": [ { "id": "NP_001033698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033698", "type": "external" } ], "gene_names_uniprotkb": "Mapt; Mtapt; Tau", "gene_names_refseq": "Mapt; Mtapt; PHF-tau; Tau", "protein_names_uniprotkb": "Microtubule-associated protein tau; Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau", "protein_names_refseq": "microtubule-associated protein tau isoform 1; neurofibrillary tangle protein; paired helical filament-tau", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); frontotemporal dementia 1 (Disease Ontology:DOID:0051060); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); Pick's disease (Disease Ontology:DOID:11870); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); progressive supranuclear palsy (Disease Ontology:DOID:678); tauopathy (Disease Ontology:DOID:680); vascular dementia (Disease Ontology:DOID:8725); frontotemporal dementia (Disease Ontology:DOID:9255); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17762); (R-MMU-264870); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;1374898;14999081;15345747;15705853;15953362;16452087;16630055;17078951;17114649;17242355;17482548;21183079;21726571;21750661;23807304;24326295;26192747;26816085;27975253;30059200;3122323;32848054;35357812;35879403;36288343;36888912;39927985;40684658;40885482;7877441;7927211;8402267", "class_list": "", "function": "Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 0, "mined_o_glycosites": 2, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 48, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 23, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A2A5Y9;P10638;Q60684;Q60685;Q60686;Q62286;Q91WK4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0004857 enzyme inhibitor activity;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0032387 negative regulation of intracellular transport;GO:0046785 microtubule polymerization;GO:0047497 mitochondrion transport along microtubule;GO:1903748 negative regulation of establishment of protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P10637-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100010001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70387-1", "uniprot_id": [ { "id": "HFE_MOUSE", "url": "https://www.uniprot.org/uniprot/P70387", "type": "external" } ], "mass": 40534.0, "length": 359, "protein_name": "Hereditary hemochromatosis protein homolog", "gene_name": "Hfe", "organism": "Mouse", "refseq_name": "hereditary hemochromatosis protein homolog isoform b precursor", "refseq_ac": [ { "id": "NP_001334422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334422", "type": "external" } ], "gene_names_uniprotkb": "Hfe; Mr2", "gene_names_refseq": "Hfe; MR2", "protein_names_uniprotkb": "Hereditary hemochromatosis protein homolog", "protein_names_refseq": "hereditary hemochromatosis protein homolog isoform b precursor; hereditary hemochromatosis protein homolog", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 1 (Disease Ontology:DOID:0111029); Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); dilated cardiomyopathy (Disease Ontology:DOID:12930); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); hemochromatosis (Disease Ontology:DOID:2352); ovarian cancer (Disease Ontology:DOID:2394); porphyria cutanea tarda (Disease Ontology:DOID:3132); liver disease (Disease Ontology:DOID:409); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); intestinal obstruction (Disease Ontology:DOID:8437); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15216); (R-MMU-917977)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30084848;37750297;39072788;39273097;9020055;9396865", "class_list": "", "function": "A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration., [RefSeq, PubMed]; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage., [RefSeq, PubMed]; Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 35, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14AQ5;Q5SZ90;Q9D754", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0039706 co-receptor binding;GO:1990459 transferrin receptor binding;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0002725 negative regulation of T cell cytokine production;GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0006879 intracellular iron ion homeostasis;GO:0046415 urate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70387-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ51-1", "uniprot_id": [ { "id": "MFS11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ51", "type": "external" } ], "mass": 49133.0, "length": 449, "protein_name": "UNC93-like protein MFSD11", "gene_name": "Mfsd11", "organism": "Mouse", "refseq_name": "UNC93-like protein MFSD11 isoform 1", "refseq_ac": [ { "id": "NP_848735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848735", "type": "external" } ], "gene_names_uniprotkb": "Mfsd11; Et", "gene_names_refseq": "2600014M03Rik; Mfsd11", "protein_names_uniprotkb": "UNC93-like protein MFSD11; Major facilitator superfamily domain-containing protein 11; Protein ET", "protein_names_refseq": "UNC93-like protein MFSD11 isoform 1; UNC93-like protein MFSD11; major facilitator superfamily domain-containing protein 11; protein ET", "tax_id": 10090, "disease": "", "pathway": " (mmu:69900)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;21750661;25428506;25428507;27272503;34428180;9358160", "class_list": "", "function": "Results show that Mfsd5 and Mfsd11 are both affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. Moreover, the first histological mapping of MFSD5 and MFSD11 shows ubiquitous expression in the periphery and the central nervous system of mice, where the proteins are expressed in excitatory and inhibitory mouse brain neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AA30;A2AA32;B2RQK5;O54844;Q8BJ61", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0042594 response to starvation;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BJ51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1I5-1", "uniprot_id": [ { "id": "MCEE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1I5", "type": "external" } ], "mass": 19017.0, "length": 178, "protein_name": "Methylmalonyl-CoA epimerase, mitochondrial", "gene_name": "Mcee", "organism": "Mouse", "refseq_name": "methylmalonyl-CoA epimerase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_082902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082902", "type": "external" } ], "gene_names_uniprotkb": "Mcee", "gene_names_refseq": "1110007A04Rik; Mcee", "protein_names_uniprotkb": "Methylmalonyl-CoA epimerase, mitochondrial; 5.1.99.1; DL-methylmalonyl-CoA racemase", "protein_names_refseq": "DL-methylmalonyl-CoA racemase; methylmalonyl-CoA epimerase, mitochondrial isoform 1 precursor; methylmalonyl-CoA epimerase, mitochondrial", "tax_id": 10090, "disease": "methylmalonic acidemia (Disease Ontology:DOID:14749)", "pathway": " (mmu:73724); (R-MMU-71032)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23576753;23806337;25428506;34428180;36288343", "class_list": "", "function": "Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004493 methylmalonyl-CoA epimerase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046491 L-methylmalonyl-CoA metabolic process;GO:1901290 succinyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D1I5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCS3-1", "uniprot_id": [ { "id": "MECR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCS3", "type": "external" } ], "mass": 40343.0, "length": 373, "protein_name": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial", "gene_name": "Mecr", "organism": "Mouse", "refseq_name": "enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_079573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079573", "type": "external" } ], "gene_names_uniprotkb": "Mecr; Nrbf1", "gene_names_refseq": "Mecr; NRBF-1; Nrbf1", "protein_names_uniprotkb": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 1.3.1.104; 2-enoyl thioester reductase; NRBF-1; Nuclear receptor-binding factor 1", "protein_names_refseq": "2-enoyl thioester reductase; enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 2 precursor; enoyl-[acyl-carrier-protein] reductase, mitochondrial; nuclear receptor binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial", "tax_id": 10090, "disease": "childhood-onset dystonia with optic atrophy and basal ganglia abnormalities (Disease Ontology:DOID:0081419); Leber hereditary optic neuropathy with demyelinating disease of CNS (Disease Ontology:DOID:0111756); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (mmu:26922); (R-MMU-77346)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "19440339;21750661;23576753;23806337;25428506;25605945;28369354;30084848;30266742;32440681;37507081", "class_list": "", "function": "ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance., [RefSeq, PubMed]; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (PubMed:30266742). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The results showed a ventricular dilatation behind impaired heart function upon Mecr overexpression, concurrent with appearance of dysmorphic mitochondria, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L39", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016922 nuclear receptor binding;GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DCS3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35701-1", "uniprot_id": [ { "id": "MATN3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35701", "type": "external" } ], "mass": 51845.0, "length": 481, "protein_name": "Matrilin-3", "gene_name": "Matn3", "organism": "Mouse", "refseq_name": "matrilin-3 precursor", "refseq_ac": [ { "id": "NP_034900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034900", "type": "external" } ], "gene_names_uniprotkb": "Matn3", "gene_names_refseq": "Matn3", "protein_names_uniprotkb": "Matrilin-3", "protein_names_refseq": "matrilin-3 precursor", "tax_id": 10090, "disease": "multiple epiphyseal dysplasia 5 (Disease Ontology:DOID:0070299); Marfan syndrome (Disease Ontology:DOID:14323); osteochondrodysplasia (Disease Ontology:DOID:2256); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:17182); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10656920;10660556;23956175;24129315;33227438;38520693;9287130", "class_list": "", "function": "Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks., [UniProtKB, PubMed]; Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation., [RefSeq, PubMed]; The Matrilin-3 T298M mutation predisposes for post-traumatic osteoarthritis in a knock-in mouse model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543Q2;Q9JHM0", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35701-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32442-1", "uniprot_id": [ { "id": "MEOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P32442", "type": "external" } ], "mass": 27980.0, "length": 253, "protein_name": "Homeobox protein MOX-1", "gene_name": "Meox1", "organism": "Mouse", "refseq_name": "homeobox protein MOX-1", "refseq_ac": [ { "id": "NP_034921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034921", "type": "external" } ], "gene_names_uniprotkb": "Meox1; Mox-1; Mox1", "gene_names_refseq": "D330041M02Rik; Meox1; Mox-1; Mox1; squig", "protein_names_uniprotkb": "Homeobox protein MOX-1; Mesenchyme homeobox 1", "protein_names_refseq": "homeobox protein MOX-1", "tax_id": 10090, "disease": "Klippel-Feil syndrome 2 (Disease Ontology:DOID:0080590); Klippel-Feil syndrome (Disease Ontology:DOID:10426)", "pathway": " (mmu:17285)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12925591;1363541;15024065;15039437;18417617;19520072;22206000;34428180", "class_list": "glycogene", "function": "Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543E8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0001757 somite specification", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32442-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32443-1", "uniprot_id": [ { "id": "MEOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P32443", "type": "external" } ], "mass": 33506.0, "length": 303, "protein_name": "Homeobox protein MOX-2", "gene_name": "Meox2", "organism": "Mouse", "refseq_name": "homeobox protein MOX-2", "refseq_ac": [ { "id": "NP_032610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032610", "type": "external" } ], "gene_names_uniprotkb": "Meox2; Gax; Mox-2; Mox2", "gene_names_refseq": "Gax; Meox2; Mox-2; Mox2", "protein_names_uniprotkb": "Homeobox protein MOX-2; Growth arrest-specific homeobox; Mesenchyme homeobox 2", "protein_names_refseq": "growth arrest-specific homeobox; homeobox protein MOX-2", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:17286)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10403250;12925591;1363541;16116430;16284941;25561514;34428180;7623821;7909944", "class_list": "", "function": "Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (PubMed:10403250, PubMed:12925591, PubMed:1363541). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (PubMed:10403250). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:16116430). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (By similarity). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544T6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32443-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SW45-1", "uniprot_id": [ { "id": "MKS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SW45", "type": "external" } ], "mass": 64416.0, "length": 561, "protein_name": "Tectonic-like complex member MKS1", "gene_name": "Mks1", "organism": "Mouse", "refseq_name": "tectonic-like complex member MKS1", "refseq_ac": [ { "id": "NP_001034773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034773", "type": "external" } ], "gene_names_uniprotkb": "Mks1", "gene_names_refseq": "B8d3; Mks1; avc6", "protein_names_uniprotkb": "Tectonic-like complex member MKS1; Meckel syndrome type 1 protein homolog", "protein_names_refseq": "Meckel syndrome, type 1; meckel syndrome type 1 protein homolog; tectonic-like complex member MKS1", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 1 (Disease Ontology:DOID:0070115); Bardet-Biedl syndrome 13 (Disease Ontology:DOID:0110135); Joubert syndrome 28 (Disease Ontology:DOID:0110997); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:380718); (R-MMU-5610787); (R-MMU-5620912)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16415886;17185389;19515853;19776033;21565611;21725307;21763481;22179047;34428180", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mks1 expression in mouse embryos, as determined by in situ hybridization, agrees well with the tissue phenotype of MKS., [RefSeq, PubMed]; Mks1 is required for ciliogenesis and shh signaling in mouse model of human meckel syndrome., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3W3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5SW45-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60805-1", "uniprot_id": [ { "id": "MERTK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60805", "type": "external" } ], "mass": 110157.0, "length": 994, "protein_name": "Tyrosine-protein kinase Mer", "gene_name": "Mertk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Mer isoform 2 precursor", "refseq_ac": [ { "id": "NP_032613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032613", "type": "external" } ], "gene_names_uniprotkb": "Mertk; Mer", "gene_names_refseq": "Eyk; Mertk; Mer; Nyk; nmf12", "protein_names_uniprotkb": "Tyrosine-protein kinase Mer; 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK", "protein_names_refseq": "Tyro 12; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; receptor tyrosine kinase MerTK; tyrosine-protein kinase Mer isoform 2 precursor", "tax_id": 10090, "disease": "retinitis pigmentosa 38 (Disease Ontology:DOID:0110367); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:17289); (R-MMU-202733)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10227296;12884290;14704368;15673687;18039660;19117932;19224205;20173027;20363878;20978472;21792939;26495903;27802388;30899004;33402181;34428180;36210013;7784083;9891051", "class_list": "", "function": "Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 2, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q62194", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q60805-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPV4-1", "uniprot_id": [ { "id": "MBB1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPV4", "type": "external" } ], "mass": 152037.0, "length": 1344, "protein_name": "Myb-binding protein 1A", "gene_name": "Mybbp1a", "organism": "Mouse", "refseq_name": "myb-binding protein 1A", "refseq_ac": [ { "id": "NP_058056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058056", "type": "external" } ], "gene_names_uniprotkb": "Mybbp1a; P160", "gene_names_refseq": "Mybbp1a; P160; p160MBP; p67MBP", "protein_names_uniprotkb": "Myb-binding protein 1A; Myb-binding protein of 160 kDa", "protein_names_refseq": "myb-binding protein 1A; myb-binding protein of 160 kDa; nuclear protein P160", "tax_id": 10090, "disease": "", "pathway": " (mmu:18432); (R-MMU-5250924)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;11956195;12941609;14744933;15345747;16452087;17242355;19129230;19131326;19144319;21183079;21540332;21952136;22645316;24463520;24788674;25153642;25428506;25428507;25605945;29187734;30084848;30779550;31219806;34428180;34887587;35820727;37298588;38064566;38583415;39627609;39927985;9447996", "class_list": "", "function": "In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response., [RefSeq, PubMed]; Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:11956195, PubMed:14744933, PubMed:9447996). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35851;Q80Y66;Q8R4X2;Q99KP0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex;GO:0110016 B-WICH complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q7TPV4-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGV8-1", "uniprot_id": [ { "id": "MID51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGV8", "type": "external" } ], "mass": 51184.0, "length": 463, "protein_name": "Mitochondrial dynamics protein MID51", "gene_name": "Mief1", "organism": "Mouse", "refseq_name": "mitochondrial dynamics protein MID51 isoform 1", "refseq_ac": [ { "id": "NP_848834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848834", "type": "external" } ], "gene_names_uniprotkb": "Mief1; Mid51; Smcr7l", "gene_names_refseq": "A230016E22; Mief1; Smcr7l", "protein_names_uniprotkb": "Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like", "protein_names_refseq": "Smith-Magenis syndrome chromosome region, candidate 7-like; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51 isoform 1; mitochondrial dynamics protein MID51; mitochondrial dynamics protein of 51 kDa homolog", "tax_id": 10090, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (mmu:239555); (R-MMU-9937383)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17114649;21183079;21750661;23283981;23921378;24508339;26101352;27076521", "class_list": "", "function": "ADP is an essential cofactor for MiD51 during mitochondrial fission., [RefSeq, PubMed]; MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria., [RefSeq, PubMed]; MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity., [RefSeq, PubMed]; Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L., [UniProtKB, PubMed, PubMed]; This paper combines confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the endoplasmic reticulum in mitochondrial fission., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4Y9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0090314 positive regulation of protein targeting to membrane;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGV8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3X9-1", "uniprot_id": [ { "id": "MFA3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3X9", "type": "external" } ], "mass": 45342.0, "length": 409, "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "Mfap3l", "organism": "Mouse", "refseq_name": "microfibrillar-associated protein 3-like isoform a precursor", "refseq_ac": [ { "id": "NP_001171352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171352", "type": "external" } ], "gene_names_uniprotkb": "Mfap3l; Kiaa0626", "gene_names_refseq": "4933428A15Rik; 5430405D20Rik; Mfap3l; NYD-sp9; mKIAA0626", "protein_names_uniprotkb": "Microfibrillar-associated protein 3-like", "protein_names_refseq": "microfibrillar-associated protein 3-like isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71306)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;34428180;37828378", "class_list": "", "function": "May participate in the nuclear signaling of EGFR and MAPK1/ERK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80TV6;Q8BJA9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D3X9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61190-1", "uniprot_id": [ { "id": "I10R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61190", "type": "external" } ], "mass": 39774.0, "length": 349, "protein_name": "Interleukin-10 receptor subunit beta", "gene_name": "Il10rb", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il10rb; Crfb4", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-10 receptor subunit beta; CRF2-4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; Interleukin-10 receptor subunit 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "graft-versus-host disease (Disease Ontology:DOID:0081267); inflammatory bowel disease 25 (Disease Ontology:DOID:0110909); hepatitis B (Disease Ontology:DOID:2043); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (R-MMU-6783783); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19144319;21750661;35984892;37828378;9047351;9463407", "class_list": "", "function": "Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004920 interleukin-10 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:1905571 interleukin-10 receptor complex", "go_biological_process": "GO:0051607 defense response to virus;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway;GO:1901857 positive regulation of cellular respiration;GO:0140105 interleukin-10-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35632-1", "uniprot_id": [ { "id": "HYAL2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35632", "type": "external" } ], "mass": 53618.0, "length": 473, "protein_name": "Hyaluronidase-2", "gene_name": "Hyal2", "organism": "Mouse", "refseq_name": "hyaluronidase-2 precursor", "refseq_ac": [ { "id": "NP_034619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034619", "type": "external" } ], "gene_names_uniprotkb": "Hyal2", "gene_names_refseq": "Hyal2", "protein_names_uniprotkb": "Hyaluronidase-2; 3.2.1.35; Hyal-2; Hyaluronoglucosaminidase-2", "protein_names_refseq": "hyal-2; hyaluronidase-2 precursor; hyaluronidase-2", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:15587); (R-MMU-2142845); (R-MMU-2160916)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11296287;11731268;11960552;18772348;19349973;21750661;23172227;26495903;26515055;28081210;28765635;30899004;31262781;34428180;37828378;38490466;9790770", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (Probable). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:18772348, PubMed:23172227, PubMed:26515055, PubMed:28081210)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyal-2 enhancement of tumor necrosis factor-alpha-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1. Publication Status: Online-Only, [RefSeq, PubMed]; Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells., [RefSeq, PubMed]; Knockdown of Hyal2 in articular cartilage induced osteoarthritis development and progression possibly mediated by an imbalance of hyaluronan metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Mice deficient in HYAL2 are more susceptible to an acute model of colitis, and this increased susceptibility is abrogated by transfusion of HYAL2-competent platelets., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35631;Q99MS9;Q99MT0", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0001618 virus receptor activity;GO:0030971 receptor tyrosine kinase binding;GO:0050431 transforming growth factor beta binding;GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0010764 negative regulation of fibroblast migration;GO:0071493 cellular response to UV-B;GO:0042117 monocyte activation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O35632-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01867-1", "uniprot_id": [ { "id": "IGG2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P01867", "type": "external" } ], "mass": 44259.0, "length": 404, "protein_name": "Immunoglobulin heavy constant gamma 2B", "gene_name": "Ighg2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighg2b; Igh-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant gamma 2B; Ig gamma-2B chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-977606)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "117548;117549;20173027;20571061;21750661;24082034;30084848;34428180;34887587;35984892;36064721;37507081;6283537;6766534;6799207;6803173;7512967", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P01866", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0042571 immunoglobulin complex, circulating;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0019731 antibacterial humoral response;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0050766 positive regulation of phagocytosis;GO:0006910 phagocytosis, recognition", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P01867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100010000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BV49-1", "uniprot_id": [ { "id": "IFIX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BV49", "type": "external" } ], "mass": 46887.0, "length": 420, "protein_name": "Pyrin and HIN domain-containing protein 1", "gene_name": "Ifi209; Pyhin1", "organism": "Mouse", "refseq_name": "pyrin and HIN domain-containing protein 1", "refseq_ac": [ { "id": "NP_778191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778191", "type": "external" } ], "gene_names_uniprotkb": "Ifi209; Pyhin1; Ifi209; Ifix; Pyhin1", "gene_names_refseq": "4930422C14; Ifi209; Ifix; Pyhin-1; Pyhin1", "protein_names_uniprotkb": "Pyrin and HIN domain-containing protein 1; Ifi-209; Interferon-inducible protein 209; Interferon-inducible protein X; Interferon-inducible protein p209", "protein_names_refseq": "ifi-209; interferon-inducible protein 209; interferon-inducible protein X; interferon-inducible protein p209; pyrin and HIN domain family, member 1; pyrin and HIN domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:236312)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15896773;21750661;23606517;26495903;34428180;39627609;40997131", "class_list": "", "function": "Promotes LPS-induced IFN-beta and NO production in macrophages, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNA6;Q3KNA7;Q8BLY5;Q8BVS6", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BV49-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z461-1", "uniprot_id": [ { "id": "HERC6_MOUSE", "url": "https://www.uniprot.org/uniprot/F2Z461", "type": "external" } ], "mass": 112928.0, "length": 1003, "protein_name": "E3 ISG15--protein ligase Herc6", "gene_name": "Herc6", "organism": "Mouse", "refseq_name": "E3 ISG15--protein ligase Herc6", "refseq_ac": [ { "id": "NP_080268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080268", "type": "external" } ], "gene_names_uniprotkb": "Herc6", "gene_names_refseq": "1700121D12Rik; 2510038N07Rik; 4930427L17Rik; CEB1; Herc5; Herc6", "protein_names_uniprotkb": "E3 ISG15--protein ligase Herc6; 2.3.2.-", "protein_names_refseq": "E3 ISG15--protein ligase Herc6; hect domain and RLD 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67138); (R-MMU-983168)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "20385878;21750661;22138649;22272257;25428506;30084848;30779550;31219806;31599954;34203471;34428180;35820727;37279284;37651190", "class_list": "", "function": "Data show that the HerC6 N-terminal RCC1-like domain (RLD) allows ISG15 conjugation., [RefSeq, PubMed]; Expression of the Herc5-mediated ubiquitin-like protein ISGylation system can distinctly potentiate interferon-beta-induced antiviral effects against influenza A virus., [RefSeq, PubMed]; MHERC6 is essential for endogenous murine ISGylation and thus represents the dominant ISG15 E3 ligase in mice., [RefSeq, PubMed]; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon., [UniProtKB, PubMed]; Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEA7;Q9CU70", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "F2Z461-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1G5-1", "uniprot_id": [ { "id": "I20L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1G5", "type": "external" } ], "mass": 41020.0, "length": 368, "protein_name": "Interferon-stimulated 20 kDa exonuclease-like 2", "gene_name": "Isg20l2", "organism": "Mouse", "refseq_name": "interferon-stimulated 20 kDa exonuclease-like 2", "refseq_ac": [ { "id": "NP_808331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808331", "type": "external" } ], "gene_names_uniprotkb": "Isg20l2", "gene_names_refseq": "4930429N24; Isg20l2", "protein_names_uniprotkb": "Interferon-stimulated 20 kDa exonuclease-like 2; 3.1.-.-", "protein_names_refseq": "interferon-stimulated 20 kDa exonuclease-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229504); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;29187734;34428180", "class_list": "", "function": "3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMV7;Q8BKA9", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006396 RNA processing;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U1G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T19-1", "uniprot_id": [ { "id": "HEPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80T19", "type": "external" } ], "mass": 9410.0, "length": 83, "protein_name": "Hepcidin-2", "gene_name": "Hamp2", "organism": "Mouse", "refseq_name": "hepcidin-2 preproprotein", "refseq_ac": [ { "id": "NP_899080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899080", "type": "external" } ], "gene_names_uniprotkb": "Hamp2; Hepc2", "gene_names_refseq": "1810073K19Rik; HEPC2; Hamp2", "protein_names_uniprotkb": "Hepcidin-2", "protein_names_refseq": "hepcidin-2 preproprotein; hepcidin-2", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 2B (Disease Ontology:DOID:0111032); iron deficiency anemia (Disease Ontology:DOID:11758); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); pure red-cell aplasia (Disease Ontology:DOID:1340); extrahepatic cholestasis (Disease Ontology:DOID:13619); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:66438)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12729891;14564671;21750661;26826199;31601421;34428180", "class_list": "", "function": "Both Hepc 1 and Hepc 2 expression responds coordinately to dietary iron. This work provides additional evidence of the key role of Hepc in the regulation of iron homeostasis., [RefSeq, PubMed]; Comparative analysis of sequence, genomic structure and expression of the hepcidin 1 and 2 genes., [RefSeq, PubMed]; Hepcidin role in the iron homeostasis., [RefSeq, PubMed]; Radiation exposure directly or indirectly induces urinary excretion of hepcidin-2 at least in part by the upregulation of Hamp2 mRNA in the liver., [RefSeq, PubMed]; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis., [UniProtKB]; This gene encodes a peptide hormone that functions in the regulation of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Transgenic mice overexpressing the encoded protein develop normally with hematologic parameters similar to the non-transgenic mice. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFW2", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0097690 iron ion transmembrane transporter inhibitor activity;GO:0141108 transporter regulator activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005615 extracellular space;GO:0014704 intercalated disc;GO:0005576 extracellular region", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80T19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62748-1", "uniprot_id": [ { "id": "HPCL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P62748", "type": "external" } ], "mass": 22338.0, "length": 193, "protein_name": "Hippocalcin-like protein 1", "gene_name": "Hpcal1", "organism": "Mouse", "refseq_name": "hippocalcin-like protein 1", "refseq_ac": [ { "id": "NP_057886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057886", "type": "external" } ], "gene_names_uniprotkb": "Hpcal1", "gene_names_refseq": "Hpcal1; NVL-3; NVP-3; Nvp3; VILIP3; Vnsl3; Vsnl3", "protein_names_uniprotkb": "Hippocalcin-like protein 1; NVL-3; NVP-3; Neural visinin-like protein 3; VILIP-3; Visinin-like protein 3", "protein_names_refseq": "hippocalcin-like protein 1; neural visinin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:53602)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14739275;21750661;35403545;36438486", "class_list": "", "function": "Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation., [UniProtKB, UniProtKB, UniProtKB]; Visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35333", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62748-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97290-1", "uniprot_id": [ { "id": "IC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97290", "type": "external" } ], "mass": 55585.0, "length": 504, "protein_name": "Plasma protease C1 inhibitor", "gene_name": "Serping1", "organism": "Mouse", "refseq_name": "plasma protease C1 inhibitor precursor", "refseq_ac": [ { "id": "NP_033906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033906", "type": "external" } ], "gene_names_uniprotkb": "Serping1; C1nh", "gene_names_refseq": "C1 Inh; C1INH.; C1Inh; C1nh; Serping1", "protein_names_uniprotkb": "Plasma protease C1 inhibitor; C1 Inh; C1 esterase inhibitor; C1-inhibiting factor; C1Inh; Serpin G1", "protein_names_refseq": "C1 esterase inhibitor; C1-inhibiting factor; complement component 1 inhibitor; plasma protease C1 inhibitor precursor; plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) proteinase inhibitor, clade G, member 1; serpin G1", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); COVID-19 (Disease Ontology:DOID:0080600); hereditary angioedema type I (Disease Ontology:DOID:0080939); toxic shock syndrome (Disease Ontology:DOID:14115); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); glioblastoma (Disease Ontology:DOID:3068); cerebral infarction (Disease Ontology:DOID:3526); macular degeneration (Disease Ontology:DOID:4448); pancreatitis (Disease Ontology:DOID:4989); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:12258); (R-MMU-114608); (R-MMU-9769739); (R-MMU-977606); (R-MMU-9855719)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11956243;12421980;16944957;17330941;21750661;25428506;26495903;26740625;32152506;34354123;34428180;35982894;38212417;9199246;9652403", "class_list": "", "function": "A novel murine in vivo model for acute hereditary angioedema attacks. Publication Status: Online-Only, [RefSeq, PubMed]; Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor., [RefSeq, PubMed]; Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serping1 associated with alpha-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson's disease mice. Publication Status: Online-Only, [RefSeq, PubMed]; Transgenic mice have been generated that express human C1 inhibitor mRNA and protein under the control of the human promoter and regulatory elements; C1nh production is demonstrated in mouse brain, spleen, liver, heart, kidney, and lung., [RefSeq, PubMed]; Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ATR7;O88330;Q99M43;Q9QX09", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001869 negative regulation of complement activation, lectin pathway;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97290-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLH7-1", "uniprot_id": [ { "id": "HIRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLH7", "type": "external" } ], "mass": 65215.0, "length": 601, "protein_name": "HIRA-interacting protein 3", "gene_name": "Hirip3", "organism": "Mouse", "refseq_name": "HIRA-interacting protein 3 isoform 1", "refseq_ac": [ { "id": "NP_766334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766334", "type": "external" } ], "gene_names_uniprotkb": "Hirip3", "gene_names_refseq": "B130036O03; Hirip3", "protein_names_uniprotkb": "HIRA-interacting protein 3", "protein_names_refseq": "HIRA-interacting protein 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233876)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;17622165;21183079;21750661", "class_list": "", "function": "Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSF3", "ec_number_list": [], "go_molecular_function": "GO:0000511 H2A-H2B histone complex chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BLH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35047-1", "uniprot_id": [ { "id": "HOP2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35047", "type": "external" } ], "mass": 24748.0, "length": 217, "protein_name": "Homologous-pairing protein 2 homolog", "gene_name": "Psmc3ip", "organism": "Mouse", "refseq_name": "homologous-pairing protein 2 homolog", "refseq_ac": [ { "id": "NP_032975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032975", "type": "external" } ], "gene_names_uniprotkb": "Psmc3ip; Hop2; Tbpip", "gene_names_refseq": "GT198; HOP2; Psmc3ip; Tbpip", "protein_names_uniprotkb": "Homologous-pairing protein 2 homolog; PSMC3-interacting protein; Proteasome 26S ATPase subunit 3-interacting protein; TBP-1-interacting protein; Tat-binding protein 1-interacting protein", "protein_names_refseq": "PSMC3-interacting protein; TBP-1-interacting protein; homologous-pairing protein 2 homolog; proteasome 26S ATPase subunit 3-interacting protein; tat-binding protein 1-interacting protein", "tax_id": 10090, "disease": "ovarian dysgenesis 3 (Disease Ontology:DOID:0080495)", "pathway": " (mmu:19183)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11739747;14667414;15192114;15834424;16675459;17426123;17639080;17639081;21750661;31433867;34600885;9345291", "class_list": "", "function": "C-terminal basic region of TBPIP/HOP2 is required for efficient DNA binding and is also essential for its homologous pairing stimulation activity, [RefSeq, PubMed]; Data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis, [RefSeq, PubMed]; Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation., [RefSeq, PubMed]; Hop2 interacts with the transcription factor CEBPalpha and suppresses adipocyte differentiation., [RefSeq, PubMed]; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V035", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0003690 double-stranded DNA binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0120231 DNA recombinase auxiliary factor complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0030521 androgen receptor signaling pathway;GO:0030520 estrogen receptor signaling pathway;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35047-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCN7-1", "uniprot_id": [ { "id": "HLTF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCN7", "type": "external" } ], "mass": 113317.0, "length": 1003, "protein_name": "DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF", "gene_name": "Hltf", "organism": "Mouse", "refseq_name": "DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF", "refseq_ac": [ { "id": "NP_033236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033236", "type": "external" } ], "gene_names_uniprotkb": "Hltf; Smarca3; Snf2l3; Zbu1", "gene_names_refseq": "Hltf; P113; Smarca3; Snf2l3", "protein_names_uniprotkb": "DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF; 2.3.2.27; 3.6.4.-; HLTF; Helicase-like transcription factor; P113; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3; TNF-response element-binding protein", "protein_names_refseq": "DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; TNF-response element-binding protein; sucrose nonfermenting protein 2-like 3", "tax_id": 10090, "disease": "gastrointestinal system cancer (Disease Ontology:DOID:3119)", "pathway": " (mmu:20585); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "18250455;18299400;20173027;21457752;21750661;21913724;25428506;25428507;30084848;30779550;31219806;31599954;34428180;37624843;9126292;9427542", "class_list": "", "function": "Functions as a DNA-dependent ATPase and E3 ubiquitin-protein ligase involved in chromatin regulation and DNA damage tolerance (DDT) (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of monoubiquitinated PCNA at 'Lys-164' in response to genotoxic stress, promoting error-free postreplication repair via template switching (By similarity). Acts as an epigenetic regulator by promoting recruitment of DNMT1, thereby ensuring DNA methylation inheritance: specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and mediates histone H3 'Lys-23' polyubiquitination (H3K23ub), a docking site for DNMT1, leading to DNMT1 recruitment and replication-coupled DNA methylation maintenance (By similarity). Catalyzes formation of H3K23ub in two steps: first mediates monoubiquitination together with UBE2E1 and UBE2D2, and then extends ubiquitin chains via 'Lys-63'-linked ubiquitination together with UBE2N and UBE2V2 (By similarity). Also acts as a chromatin redodeling factor, thereby regulating transcription (PubMed:9126292, PubMed:9427542). Exhibits ATP-dependent double-stranded DNA (dsDNA) translocase activity but lacks classical helicase activity; mediates replication fork reversal by concertedly unwinding and annealing nascent and parental strands, thereby suppressing DNA synthesis and maintaining genomic stability (By similarity). Resolves G-quadruplex (G4) DNA structures in cooperation with MSH2, limiting replication stress and G4 accumulation across the cell cycle (By similarity). Contributes to nucleotide excision repair by evicting lesion-containing oligonucleotides using its HIRAN and ATPase domains (By similarity). Can displace single-stranded DNA from triplex structures through ATP-dependent dsDNA translocation (By similarity). Also has protein clearing activity at the stalled replication fork, facilitating restart of DNA replication (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta cells resulting in neonatal lethality. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35596;O35597;Q80VT6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6PCN7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08983-1", "uniprot_id": [ { "id": "HPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08983", "type": "external" } ], "mass": 79853.0, "length": 704, "protein_name": "BLOC-3 complex member HPS1", "gene_name": "Hps1", "organism": "Mouse", "refseq_name": "BLOC-3 complex member HPS1 isoform 1", "refseq_ac": [ { "id": "NP_062297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062297", "type": "external" } ], "gene_names_uniprotkb": "Hps1; Ep; Hps", "gene_names_refseq": "6030422N11Rik; Gm21361; Hps1; Hps; ep", "protein_names_uniprotkb": "BLOC-3 complex member HPS1; Hermansky-Pudlak syndrome 1 protein homolog", "protein_names_refseq": "BLOC-3 complex member HPS1 isoform 1; BLOC-3 complex member HPS1; Hermansky-Pudlak syndrome 1 homolog; Hermansky-Pudlak syndrome protein homolog; hermansky-Pudlak syndrome 1 protein homolog; pale ear", "tax_id": 10090, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); Hermansky-Pudlak syndrome 1 (Disease Ontology:DOID:0060539); platelet storage pool deficiency (Disease Ontology:DOID:2223); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:192236); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;33224134;35820727;9158155;9256466", "class_list": "", "function": "Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38., [UniProtKB, UniProtKB]; HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35155;O35725;O35950", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0031085 BLOC-3 complex;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1903232 melanosome assembly;GO:0003016 respiratory system process;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08983-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08890-1", "uniprot_id": [ { "id": "IDS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08890", "type": "external" } ], "mass": 62186.0, "length": 552, "protein_name": "Iduronate 2-sulfatase", "gene_name": "Ids", "organism": "Mouse", "refseq_name": "iduronate 2-sulfatase isoform 1 precursor", "refseq_ac": [ { "id": "NP_034628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034628", "type": "external" } ], "gene_names_uniprotkb": "Ids", "gene_names_refseq": "Ids", "protein_names_uniprotkb": "Iduronate 2-sulfatase; 3.1.6.13; Alpha-L-iduronate sulfate sulfatase", "protein_names_refseq": "alpha-L-iduronate sulfate sulfatase; iduronate 2-sulfatase isoform 1 precursor; iduronate sulfatase", "tax_id": 10090, "disease": "mucopolysaccharidosis II (Disease Ontology:DOID:12799)", "pathway": " (mmu:15931); (R-MMU-2024096); (R-MMU-2024101)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15149955;16174644;21750661;26495903;30899004;34203471;37860991;8325651", "class_list": "glycogene", "function": "Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate., [UniProtKB, UniProtKB]; Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q32KI7;Q3TM30", "ec_number_list": [ { "id": "3.1.6.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.13", "type": "external" } ], "go_molecular_function": "GO:0004423 iduronate-2-sulfatase activity;GO:0005509 calcium ion binding;GO:0008484 sulfuric ester hydrolase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0006027 glycosaminoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q08890-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08624-1", "uniprot_id": [ { "id": "HXC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08624", "type": "external" } ], "mass": 29865.0, "length": 264, "protein_name": "Homeobox protein Hox-C4", "gene_name": "Hoxc4", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C4", "refseq_ac": [ { "id": "NP_038581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038581", "type": "external" } ], "gene_names_uniprotkb": "Hoxc4; Hox-3.5; Hoxc-4", "gene_names_refseq": "Hox-3.5; Hoxc4", "protein_names_uniprotkb": "Homeobox protein Hox-C4; Homeobox protein Hox-3.5", "protein_names_refseq": "homeo box C4; homeobox protein Hox-3.5; homeobox protein Hox-C4", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:15423)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1363091;1720547;21750661;34428180;8099712", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08624-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61670-1", "uniprot_id": [ { "id": "HLX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61670", "type": "external" } ], "mass": 50079.0, "length": 476, "protein_name": "H2.0-like homeobox protein", "gene_name": "Hlx", "organism": "Mouse", "refseq_name": "H2.0-like homeobox protein", "refseq_ac": [ { "id": "NP_032276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032276", "type": "external" } ], "gene_names_uniprotkb": "Hlx; Hlx1", "gene_names_refseq": "Hlx1; Hlx", "protein_names_uniprotkb": "H2.0-like homeobox protein; Homeobox protein HLX1", "protein_names_refseq": "H2.0-like homeo box 1; H2.0-like homeobox protein; homeobox protein HLX1", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (mmu:15284)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12055627;1672660;21750661;24934598;28701693;28898547;32782141", "class_list": "", "function": "HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings, [RefSeq, PubMed]; Methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx., [RefSeq, PubMed]; Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61670-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW74-1", "uniprot_id": [ { "id": "HLF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW74", "type": "external" } ], "mass": 33149.0, "length": 295, "protein_name": "Hepatic leukemia factor", "gene_name": "Hlf", "organism": "Mouse", "refseq_name": "hepatic leukemia factor isoform 1", "refseq_ac": [ { "id": "NP_766151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766151", "type": "external" } ], "gene_names_uniprotkb": "Hlf", "gene_names_refseq": "E230015K02Rik; Hlf", "protein_names_uniprotkb": "Hepatic leukemia factor", "protein_names_refseq": "hepatic leukemia factor isoform 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:217082)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15175240;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PF83", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0035914 skeletal muscle cell differentiation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BW74-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08650-1", "uniprot_id": [ { "id": "HYAS3_MOUSE", "url": "https://www.uniprot.org/uniprot/O08650", "type": "external" } ], "mass": 63349.0, "length": 554, "protein_name": "Hyaluronan synthase 3", "gene_name": "Has3", "organism": "Mouse", "refseq_name": "hyaluronan synthase 3", "refseq_ac": [ { "id": "NP_001317977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317977", "type": "external" } ], "gene_names_uniprotkb": "Has3", "gene_names_refseq": "Has3", "protein_names_uniprotkb": "Hyaluronan synthase 3; 2.4.1.212; HA synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3", "protein_names_refseq": "HA synthase 3; hyaluronan synthase 3; hyaluronate synthase 3; hyaluronic acid synthase 3", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:15118); (R-MMU-2142845)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10455188;16014622;21750661;24790187;9083017", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEB9", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0045893 positive regulation of DNA-templated transcription;GO:1900106 positive regulation of hyaluranon cable assembly;GO:0030213 hyaluronan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08650-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09030-1", "uniprot_id": [ { "id": "I13R1_MOUSE", "url": "https://www.uniprot.org/uniprot/O09030", "type": "external" } ], "mass": 48402.0, "length": 424, "protein_name": "Interleukin-13 receptor subunit alpha-1", "gene_name": "Il13ra1", "organism": "Mouse", "refseq_name": "interleukin-13 receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_598751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598751", "type": "external" } ], "gene_names_uniprotkb": "Il13ra1; Il13ra; Il13r", "gene_names_refseq": "CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra1; Il13ra; NR4", "protein_names_uniprotkb": "Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Interleukin-13-binding protein; NR4; Novel cytokine receptor 4", "protein_names_refseq": "IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; interleukin-13 receptor subunit alpha-1 precursor; interleukin-13 receptor subunit alpha-1; interleukin-13-binding protein; novel cytokine receptor 4", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); pulmonary hypertension (Disease Ontology:DOID:6432); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:16164); (R-MMU-6785807)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;37828378;8552669", "class_list": "", "function": "Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (By similarity)., [UniProtKB]; This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9890, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q7TT27", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity;GO:0016515 interleukin-13 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005898 interleukin-13 receptor complex;GO:0016516 interleukin-4 receptor complex", "go_biological_process": "GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0019221 cytokine-mediated signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway;GO:0007259 cell surface receptor signaling pathway via JAK-STAT;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O09030-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88786-1", "uniprot_id": [ { "id": "I13R2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88786", "type": "external" } ], "mass": 44483.0, "length": 383, "protein_name": "Interleukin-13 receptor subunit alpha-2", "gene_name": "Il13ra2", "organism": "Mouse", "refseq_name": "interleukin-13 receptor subunit alpha-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001292988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292988", "type": "external" } ], "gene_names_uniprotkb": "Il13ra2", "gene_names_refseq": "CD213a2; IL-13R-alpha-2; Il13ra2", "protein_names_uniprotkb": "Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2", "protein_names_refseq": "interleukin-13 receptor subunit alpha-2 isoform 2 precursor; interleukin-13 receptor subunit alpha-2", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:16165); (R-MMU-6785807)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10491413;12642601;12642602;17114462;34391816;37963919;38291404;9725226;9916716", "class_list": "", "function": "A soluble form of the IL-13 receptor alpha 2 inhibited IL-13 activity and the progression of liver fibrosis in schistosomiasis., [RefSeq, PubMed]; Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:12642602). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1., [UniProtKB, PubMed, UniProtKB]; IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis., [RefSeq, PubMed]; Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2. Publication Status: Online-Only, [RefSeq, PubMed]; Studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response, [RefSeq, PubMed]; The IL-13 receptor alpha 2 can be used to inhibit type-2 cytokine-mediated inflammation in the lung., [RefSeq, PubMed]; This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A3F812;Q3V2V5", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0019221 cytokine-mediated signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88786-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01572-1", "uniprot_id": [ { "id": "IFNA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P01572", "type": "external" } ], "mass": 21646.0, "length": 189, "protein_name": "Interferon alpha-1", "gene_name": "Ifna1", "organism": "Mouse", "refseq_name": "interferon alpha-1 precursor", "refseq_ac": [ { "id": "NP_034632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034632", "type": "external" } ], "gene_names_uniprotkb": "Ifna1", "gene_names_refseq": "If1ai14; Ifa1; Ifna1", "protein_names_uniprotkb": "Interferon alpha-1; IFN-alpha-1", "protein_names_refseq": "IFN-alpha-1; interferon 1ai14; interferon alpha family gene 1; interferon alpha-1 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15962); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15254193;2987811;36681180;38660315;6188104;9244179", "class_list": "", "function": "Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression., [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M0A3;Q810G7", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01572-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01753-1", "uniprot_id": [ { "id": "HVM09_MOUSE", "url": "https://www.uniprot.org/uniprot/P01753", "type": "external" } ], "mass": 12890.0, "length": 117, "protein_name": "Ig heavy chain V region 186-1", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 186-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6788376", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11271", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01753-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01758-1", "uniprot_id": [ { "id": "HVM14_MOUSE", "url": "https://www.uniprot.org/uniprot/P01758", "type": "external" } ], "mass": 12972.0, "length": 117, "protein_name": "Ig heavy chain V region 108A", "gene_name": "Igh-VJ558", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igh-VJ558", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 108A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "37453647;6789211", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01758-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01786-1", "uniprot_id": [ { "id": "HVM17_MOUSE", "url": "https://www.uniprot.org/uniprot/P01786", "type": "external" } ], "mass": 12975.0, "length": 117, "protein_name": "Ig heavy chain V region MOPC 47A", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region MOPC 47A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "115869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01786-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01787-1", "uniprot_id": [ { "id": "HVM18_MOUSE", "url": "https://www.uniprot.org/uniprot/P01787", "type": "external" } ], "mass": 13777.0, "length": 123, "protein_name": "Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "3141511;6769593;7231520;813561;819932", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01787-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01791-1", "uniprot_id": [ { "id": "HVM22_MOUSE", "url": "https://www.uniprot.org/uniprot/P01791", "type": "external" } ], "mass": 13896.0, "length": 123, "protein_name": "Ig heavy chain V region HPCM6", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region HPCM6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7231520", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01791-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01794-1", "uniprot_id": [ { "id": "HVM25_MOUSE", "url": "https://www.uniprot.org/uniprot/P01794", "type": "external" } ], "mass": 13807.0, "length": 123, "protein_name": "Ig heavy chain V region HPCG14", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region HPCG14", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7231520", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01794-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01795-1", "uniprot_id": [ { "id": "HVM26_MOUSE", "url": "https://www.uniprot.org/uniprot/P01795", "type": "external" } ], "mass": 16219.0, "length": 144, "protein_name": "Ig heavy chain V region M167", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region M167", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "6101208;819932", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01795-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01796-1", "uniprot_id": [ { "id": "HVM27_MOUSE", "url": "https://www.uniprot.org/uniprot/P01796", "type": "external" } ], "mass": 12675.0, "length": 113, "protein_name": "Ig heavy chain V-III region A4", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V-III region A4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "417344", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01796-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01801-1", "uniprot_id": [ { "id": "HVM32_MOUSE", "url": "https://www.uniprot.org/uniprot/P01801", "type": "external" } ], "mass": 12810.0, "length": 115, "protein_name": "Ig heavy chain V-III region J606", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V-III region J606", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6798111", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01801-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01806-1", "uniprot_id": [ { "id": "HVM36_MOUSE", "url": "https://www.uniprot.org/uniprot/P01806", "type": "external" } ], "mass": 12911.0, "length": 116, "protein_name": "Ig heavy chain V region 441", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 441", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6795591", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01806-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01812-1", "uniprot_id": [ { "id": "HVM42_MOUSE", "url": "https://www.uniprot.org/uniprot/P01812", "type": "external" } ], "mass": 13051.0, "length": 117, "protein_name": "Ig heavy chain V region MOPC 173", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region MOPC 173", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "11947590;5062012;6787590;812695", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01812-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06799-1", "uniprot_id": [ { "id": "IFNA7_MOUSE", "url": "https://www.uniprot.org/uniprot/P06799", "type": "external" } ], "mass": 21603.0, "length": 190, "protein_name": "Interferon alpha-7", "gene_name": "Ifna7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ifna7; Ifa7; Ifna14", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-7; IFN-alpha-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15970); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;3017340", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P06799-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09025-1", "uniprot_id": [ { "id": "HXC8_MOUSE", "url": "https://www.uniprot.org/uniprot/P09025", "type": "external" } ], "mass": 27740.0, "length": 242, "protein_name": "Homeobox protein Hox-C8", "gene_name": "Hoxc8", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C8", "refseq_ac": [ { "id": "NP_034596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034596", "type": "external" } ], "gene_names_uniprotkb": "Hoxc8; Hox-3.1; Hoxc-8", "gene_names_refseq": "D130011F21Rik; Hox-3.1; Hoxc8", "protein_names_uniprotkb": "Homeobox protein Hox-C8; Homeobox protein Hox-3.1; Homeobox protein M31", "protein_names_refseq": "homeo box C8; homeobox protein Hox-3.1; homeobox protein Hox-C8; homeobox protein M31", "tax_id": 10090, "disease": "", "pathway": " (mmu:15426); (R-MMU-9762293)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1696731;2877873;2895723;2900757;3007994;7791786", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09025-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09092-1", "uniprot_id": [ { "id": "HXA6_MOUSE", "url": "https://www.uniprot.org/uniprot/P09092", "type": "external" } ], "mass": 26335.0, "length": 232, "protein_name": "Homeobox protein Hox-A6", "gene_name": "Hoxa6", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A6", "refseq_ac": [ { "id": "NP_034584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034584", "type": "external" } ], "gene_names_uniprotkb": "Hoxa6; Hox-1.2; Hoxa-6", "gene_names_refseq": "Hox-1.2; Hoxa6", "protein_names_uniprotkb": "Homeobox protein Hox-A6; Homeobox protein Hox-1.2; Homeobox protein M5-4", "protein_names_refseq": "homeo box A6; homeobox protein Hox-1.2; homeobox protein Hox-A6; homeobox protein M5-4", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:15403)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2416462", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI98", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09092-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10629-1", "uniprot_id": [ { "id": "HXC6_MOUSE", "url": "https://www.uniprot.org/uniprot/P10629", "type": "external" } ], "mass": 26915.0, "length": 235, "protein_name": "Homeobox protein Hox-C6", "gene_name": "Hoxc6", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C6 isoform 1", "refseq_ac": [ { "id": "NP_034595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034595", "type": "external" } ], "gene_names_uniprotkb": "Hoxc6; Hox-3.3; Hoxc-6", "gene_names_refseq": "Hox-3.3; Hox-6.1; Hoxc6", "protein_names_uniprotkb": "Homeobox protein Hox-C6; Homeobox protein Hox-3.3; Homeobox protein Hox-6.1", "protein_names_refseq": "homeo box C6; homeobox protein Hox-3.3; homeobox protein Hox-6.1; homeobox protein Hox-C6 isoform 1; homeobox protein Hox-C6", "tax_id": 10090, "disease": "", "pathway": " (mmu:15425)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1684715;2458223;2570032;2901346;37150392;7905473", "class_list": "", "function": "MicroRNA-574-5p targeting HOXC6 expression inhibits the hepatocyte lipid uptake to alleviate non-alcoholic fatty liver disease., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61683", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10629-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12968-1", "uniprot_id": [ { "id": "IAPP_MOUSE", "url": "https://www.uniprot.org/uniprot/P12968", "type": "external" } ], "mass": 10022.0, "length": 93, "protein_name": "Islet amyloid polypeptide", "gene_name": "Iapp", "organism": "Mouse", "refseq_name": "islet amyloid polypeptide precursor", "refseq_ac": [ { "id": "NP_034621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034621", "type": "external" } ], "gene_names_uniprotkb": "Iapp", "gene_names_refseq": "DAP; Iapp", "protein_names_uniprotkb": "Islet amyloid polypeptide; Amylin; DAP; Diabetes-associated peptide; IAPP", "protein_names_refseq": "amylin; diabetes-associated peptide; islet amyloid polypeptide precursor", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:15874); (R-MMU-418555); (R-MMU-419812)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22872234;2666169;2668946;32152506;34203471;39433955;9278863", "class_list": "", "function": "Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The overexpression of human amylin in pancreatic beta cells facilitate the appearance of amylin aggregates in the kidney contributing to diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0016234 inclusion body", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0051260 protein homooligomerization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12968-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17919-1", "uniprot_id": [ { "id": "HXB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17919", "type": "external" } ], "mass": 31672.0, "length": 297, "protein_name": "Homeobox protein Hox-B1", "gene_name": "Hoxb1", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B1", "refseq_ac": [ { "id": "NP_032292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032292", "type": "external" } ], "gene_names_uniprotkb": "Hoxb1; Hox-2.9; Hoxb-1", "gene_names_refseq": "Hox-2.9; Hoxb1", "protein_names_uniprotkb": "Homeobox protein Hox-B1; Homeobox protein Hox-2.9", "protein_names_refseq": "homeo box B1; homeobox protein Hox-2.9; homeobox protein Hox-B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15407)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1673098;1972280;1983472", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAY6;Q9CYH3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021570 rhombomere 4 development;GO:0021571 rhombomere 5 development;GO:0021754 facial nucleus development;GO:0021546 rhombomere development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17919-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20040-1", "uniprot_id": [ { "id": "HB24_MOUSE", "url": "https://www.uniprot.org/uniprot/P20040", "type": "external" } ], "mass": 30205.0, "length": 264, "protein_name": "H-2 class II histocompatibility antigen, E-Q beta chain", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, E-Q beta chain; E-W17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2106558;2460545;37828378", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20040-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41139-1", "uniprot_id": [ { "id": "ID4_MOUSE", "url": "https://www.uniprot.org/uniprot/P41139", "type": "external" } ], "mass": 16596.0, "length": 161, "protein_name": "DNA-binding protein inhibitor ID-4", "gene_name": "Id4", "organism": "Mouse", "refseq_name": "DNA-binding protein inhibitor ID-4", "refseq_ac": [ { "id": "NP_112443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112443", "type": "external" } ], "gene_names_uniprotkb": "Id4; Id-4; Idb4", "gene_names_refseq": "Id4; Idb4; bHLHb27", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-4; Inhibitor of DNA binding 4; Inhibitor of differentiation 4", "protein_names_refseq": "DNA-binding protein inhibitor ID-4; inhibitor of differentiation 4", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:15904)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19217292;38342917;8139914;9831657;9838043", "class_list": "", "function": "Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0060741 prostate gland stromal morphogenesis;GO:0061682 seminal vesicle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41139-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51125-1", "uniprot_id": [ { "id": "ICAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P51125", "type": "external" } ], "mass": 84922.0, "length": 788, "protein_name": "Calpastatin", "gene_name": "Cast", "organism": "Mouse", "refseq_name": "calpastatin isoform 1", "refseq_ac": [ { "id": "NP_001288082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288082", "type": "external" } ], "gene_names_uniprotkb": "Cast", "gene_names_refseq": "Cast", "protein_names_uniprotkb": "Calpastatin; Calpain inhibitor", "protein_names_refseq": "calpain inhibitor; calpastatin isoform 1; calpastatin type III", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); PLACK syndrome (Disease Ontology:DOID:0070526); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Sjogren's syndrome (Disease Ontology:DOID:12894); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); vasculitis (Disease Ontology:DOID:865); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12380); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10403772;10876161;17242355;1730065;19131326;19144319;21183079;21750661;23806337;25153642;25428506;26495903;28528544;30059200;30084848;30779550;31156619;31219806;34428180;36288343;36902150", "class_list": "", "function": "Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin. Publication Status: Online-Only, [RefSeq, PubMed]; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQV4;Q9EQV5;Q9QXQ3;Q9QXQ4;Q9R0N1", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0010466 negative regulation of peptidase activity;GO:1990709 presynaptic active zone organization;GO:0043086 negative regulation of catalytic activity;GO:0030163 protein catabolic process;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P51125-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70225-1", "uniprot_id": [ { "id": "I11RB_MOUSE", "url": "https://www.uniprot.org/uniprot/P70225", "type": "external" } ], "mass": 46731.0, "length": 432, "protein_name": "Interleukin-11 receptor subunit alpha-2", "gene_name": "Il11ra2", "organism": "Mouse", "refseq_name": "interleukin-11 receptor subunit alpha-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034680", "type": "external" } ], "gene_names_uniprotkb": "Il11ra2", "gene_names_refseq": "Etl-2; Etl2; Il11ra-ps1; Il11ra2", "protein_names_uniprotkb": "Interleukin-11 receptor subunit alpha-2; IL-11 receptor subunit alpha-2; IL-11 receptor subunit beta; IL-11R subunit alpha-2; IL-11R subunit beta; IL-11R-alpha-2; IL-11R-beta; IL-11RA2; IL-11RB; Interleukin-11 receptor subunit beta", "protein_names_refseq": "IL-11 receptor subunit alpha-2; IL-11 receptor subunit beta; IL-11R subunit alpha-2; IL-11R subunit beta; IL-11R-alpha-2; IL-11R-beta; IL-11RA2; IL-11RB; interleukin 11 receptor, alpha chain 2; interleukin-11 receptor subunit alpha-2 isoform 1 precursor; interleukin-11 receptor subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042555); (mmu:16158)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20007572;8662802;8973540;9073505", "class_list": "", "function": "Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells., [UniProtKB]; Unlike humans, discrete transcripts encoding soluble and membrane forms of mouse IL-13Ralpha2 are both generated by alternative splicing., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RTL4;B1AXR8;O09074;Q78DW8", "ec_number_list": [], "go_molecular_function": "GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0032502 developmental process;GO:0007566 embryo implantation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70225-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70312-1", "uniprot_id": [ { "id": "HYAS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70312", "type": "external" } ], "mass": 63510.0, "length": 552, "protein_name": "Hyaluronan synthase 2", "gene_name": "Has2", "organism": "Mouse", "refseq_name": "hyaluronan synthase 2", "refseq_ac": [ { "id": "NP_032242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032242", "type": "external" } ], "gene_names_uniprotkb": "Has2", "gene_names_refseq": "Has2", "protein_names_uniprotkb": "Hyaluronan synthase 2; 2.4.1.212; HA synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2", "protein_names_refseq": "HA synthase 2; hyaluronan synthase 2; hyaluronan synthase homolog; hyaluronate synthase 2; hyaluronic acid synthase 2", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (mmu:15117); (R-MMU-2142845)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10455188;10930438;30084848;34428180;8643441;8798545;9016821", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (PubMed:10455188)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70411;Q62405;Q68EF7", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0001570 vasculogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70312-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01822-1", "uniprot_id": [ { "id": "HXD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01822", "type": "external" } ], "mass": 34180.0, "length": 328, "protein_name": "Homeobox protein Hox-D1", "gene_name": "Hoxd1", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D1", "refseq_ac": [ { "id": "NP_034597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034597", "type": "external" } ], "gene_names_uniprotkb": "Hoxd1; Hox-4.9; Hoxd-1", "gene_names_refseq": "Hox-4.9; Hoxd1", "protein_names_uniprotkb": "Homeobox protein Hox-D1; Homeobox protein Hox-4.9", "protein_names_refseq": "homeo box D1; homeobox protein Hox-4.9; homeobox protein Hox-D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15429)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1348361;1356009", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBQ9", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0019233 sensory perception of pain;GO:0030182 neuron differentiation;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01822-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05A56-1", "uniprot_id": [ { "id": "HYAL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05A56", "type": "external" } ], "mass": 54385.0, "length": 481, "protein_name": "Hyaluronidase-4", "gene_name": "Hyal4", "organism": "Mouse", "refseq_name": "hyaluronidase-4", "refseq_ac": [ { "id": "NP_084124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084124", "type": "external" } ], "gene_names_uniprotkb": "Hyal4", "gene_names_refseq": "4632428M18Rik; CSHY; Hyal4", "protein_names_uniprotkb": "Hyaluronidase-4; 3.2.1.35; CSHY; Chondroitin sulfate endo-beta-N-acetylgalactosaminidase; Chondroitin sulfate hydrolase; Hyal-4; Hyaluronoglucosaminidase-4", "protein_names_refseq": "chondroitin sulfate endo-beta-N-acetylgalactosaminidase; chondroitin sulfate hydrolase; hyal-4; hyaluronidase-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:77042); (R-MMU-2024101); (R-MMU-2160916)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23086929", "class_list": "glycogene;glycosylhydrolase", "function": "Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Also has chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity)., [UniProtKB]; Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9D660", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0052757 chondroitin hydrolase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030207 chondroitin sulfate proteoglycan catabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05A56-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYV2-1", "uniprot_id": [ { "id": "HHLA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYV2", "type": "external" } ], "mass": 56354.0, "length": 514, "protein_name": "HERV-H LTR-associating protein 1 homolog", "gene_name": "Hhla1", "organism": "Mouse", "refseq_name": "HERV-H LTR-associating protein 1 homolog precursor", "refseq_ac": [ { "id": "NP_001138568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138568", "type": "external" } ], "gene_names_uniprotkb": "Hhla1", "gene_names_refseq": "F930104E18Rik; Hhla1", "protein_names_uniprotkb": "HERV-H LTR-associating protein 1 homolog", "protein_names_refseq": "HERV-H LTR-associating protein 1 homolog precursor; HERV-H LTR-associating protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:654498)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TYV2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60625-1", "uniprot_id": [ { "id": "ICAM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60625", "type": "external" } ], "mass": 96946.0, "length": 917, "protein_name": "Intercellular adhesion molecule 5", "gene_name": "Icam5", "organism": "Mouse", "refseq_name": "intercellular adhesion molecule 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032345", "type": "external" } ], "gene_names_uniprotkb": "Icam5; Icam3; Tlcn", "gene_names_refseq": "CD50; ICAM-3; ICAM-5; Icam3; Icam5; TLN; Tlcn", "protein_names_uniprotkb": "Intercellular adhesion molecule 5; ICAM-5; Telencephalin", "protein_names_refseq": "intercellular adhesion molecule 3; intercellular adhesion molecule 5 isoform 1 precursor; telencephalin", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:15898); (R-MMU-198933); (R-MMU-216083)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20485683;22187327;23897576;30899004;31219806;31882402;33300544;40885482;7794412;9244438", "class_list": "glycogene", "function": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (By similarity). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:22187327)., [UniProtKB, PubMed, UniProtKB]; ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 28, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "G5E826;Q2KHL7;Q3UY19", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0042995 cell projection;GO:0031259 uropod membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0051289 protein homotetramerization;GO:0006909 phagocytosis;GO:0033631 cell-cell adhesion mediated by integrin;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "Q60625-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100100011001.111.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60819-1", "uniprot_id": [ { "id": "I15RA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60819", "type": "external" } ], "mass": 28061.0, "length": 263, "protein_name": "Interleukin-15 receptor subunit alpha", "gene_name": "Il15ra", "organism": "Mouse", "refseq_name": "interleukin-15 receptor subunit alpha isoform 2", "refseq_ac": [ { "id": "NP_001258426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258426", "type": "external" } ], "gene_names_uniprotkb": "Il15ra", "gene_names_refseq": "IL-15RA; Il15ra", "protein_names_uniprotkb": "Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA", "protein_names_refseq": "IL-15 receptor subunit alpha; IL-15R-alpha; interleukin-15 receptor subunit alpha isoform 2; interleukin-15 receptor subunit alpha", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16169); (R-MMU-8983432)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12734349;12885940;15215246;17947230;21289316;21750661;7641685", "class_list": "", "function": "High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AP35;A2AP36;A2AP37;Q80Z90;Q80Z91;Q80Z92;Q8R5E4", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042010 interleukin-15 receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031965 nuclear membrane", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0010977 negative regulation of neuron projection development;GO:0050766 positive regulation of phagocytosis;GO:0007259 cell surface receptor signaling pathway via JAK-STAT;GO:0032825 positive regulation of natural killer cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60819-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60872-1", "uniprot_id": [ { "id": "IF1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60872", "type": "external" } ], "mass": 16502.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 1A", "gene_name": "Eif1a", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 1A isoform 2", "refseq_ac": [ { "id": "NP_034250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034250", "type": "external" } ], "gene_names_uniprotkb": "Eif1a", "gene_names_refseq": "Ef1a; Eftu; Eif1a; Eif4c; eIF-1A; eIF-4C", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 1A; Eukaryotic translation initiation factor 4C; eIF-1A; eIF-4C", "protein_names_refseq": "eukaryotic translation initiation factor 1A isoform 2; eukaryotic translation initiation factor 4C", "tax_id": 10090, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:13664)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34405343;8631492;9753744", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88847;Q8R2M4;Q9CX76;Q9DB61", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60872-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61189-1", "uniprot_id": [ { "id": "ICLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61189", "type": "external" } ], "mass": 26021.0, "length": 236, "protein_name": "Methylosome subunit pICln", "gene_name": "Clns1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clns1a; Clci; Clcni", "gene_names_refseq": "", "protein_names_uniprotkb": "Methylosome subunit pICln; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; ClCI; I(Cln)", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-191859)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25605945;31219806;34428180;36210013", "class_list": "", "function": "Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:0000387 spliceosomal snRNP assembly;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61189-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61647-1", "uniprot_id": [ { "id": "HYAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61647", "type": "external" } ], "mass": 65545.0, "length": 583, "protein_name": "Hyaluronan synthase 1", "gene_name": "Has1", "organism": "Mouse", "refseq_name": "hyaluronan synthase 1", "refseq_ac": [ { "id": "NP_032241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032241", "type": "external" } ], "gene_names_uniprotkb": "Has1; Has", "gene_names_refseq": "HAS; Has1", "protein_names_uniprotkb": "Hyaluronan synthase 1; 2.4.1.212; HA synthase 1; Hyaluronate synthase 1; Hyaluronic acid synthase 1", "protein_names_refseq": "HA synthase 1; hyaluronan synthase 1; hyaluronan synthase1; hyaluronate synthase 1; hyaluronic acid synthase 1", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:15116); (R-MMU-2142845)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10455188;10617644;34428180;38518923;8626618", "class_list": "glycogene;glycosyltransferase", "function": "AbetaPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease., [RefSeq, PubMed]; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential for the synthesis of hyaluronan, a major component of most extracellular matrices that has a structural role in tissue architecture and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0044849 estrous cycle;GO:0036120 cellular response to platelet-derived growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61647-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61716-1", "uniprot_id": [ { "id": "IFNAB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61716", "type": "external" } ], "mass": 21736.0, "length": 190, "protein_name": "Interferon alpha-11", "gene_name": "Ifna11", "organism": "Mouse", "refseq_name": "interferon alpha-11 precursor", "refseq_ac": [ { "id": "NP_032359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032359", "type": "external" } ], "gene_names_uniprotkb": "Ifna11", "gene_names_refseq": "IFN-[a]11; If1ai10; Ifna11", "protein_names_uniprotkb": "Interferon alpha-11; IFN-alpha-11; Limitin", "protein_names_refseq": "IFN-alpha-11; interferon 1ai10; interferon alpha family, gene 11; interferon alpha-11 precursor; limitin", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15964); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11884139;15254193;1655578;16565497;22912583", "class_list": "", "function": "A unique and subtype-specific activation of NK cells by IFN-alpha11., [RefSeq, PubMed]; Has antiviral and antiproliferative activities (PubMed:15254193). Produced by macrophages and stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase (By similarity). During viral infection, mediates antiviral effect, either directly by inducing interferon-stimulated genes, either indirectly through stimulation of natural killer cells enabling them to control viral replication (PubMed:22912583)., [UniProtKB, PubMed, PubMed]; IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice., [RefSeq, PubMed]; Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q810G4", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61716-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHB0-1", "uniprot_id": [ { "id": "I20RA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHB0", "type": "external" } ], "mass": 61978.0, "length": 546, "protein_name": "Interleukin-20 receptor subunit alpha", "gene_name": "Il20ra", "organism": "Mouse", "refseq_name": "interleukin-20 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_766374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766374", "type": "external" } ], "gene_names_uniprotkb": "Il20ra", "gene_names_refseq": "E230031K19; Il20ra", "protein_names_uniprotkb": "Interleukin-20 receptor subunit alpha; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20R1; IL-20RA", "protein_names_refseq": "IL-20 receptor subunit alpha; IL-20R-alpha; IL-20R1; IL-20RA; interleukin-20 receptor subunit alpha precursor; interleukin-20 receptor subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:237313); (R-MMU-5684996); (R-MMU-8854691)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19078987;23811545;25428506;30084848;34428180;37828378", "class_list": "", "function": "IL-20R1 and IL-20R2 are constitutively express in the brain., [RefSeq, PubMed]; MIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice., [RefSeq, PubMed]; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW64", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0030876 interleukin-20 receptor complex", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PHB0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W15-1", "uniprot_id": [ { "id": "IBPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W15", "type": "external" } ], "mass": 28573.0, "length": 270, "protein_name": "Insulin-like growth factor-binding protein-like 1", "gene_name": "Igfbpl1", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein-like 1 precursor", "refseq_ac": [ { "id": "NP_061211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061211", "type": "external" } ], "gene_names_uniprotkb": "Igfbpl1; Igfbprp4", "gene_names_refseq": "2810011G06Rik; 2810453O06Rik; IGFBPL; Igfbpl1", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein-like 1; IGFBP-rP4; IGFBP-related protein 10; Insulin-like growth factor-binding-related protein 4", "protein_names_refseq": "IGFBP-like protein; IGFBP-rP4; IGFBP-related protein 10; insulin-like growth factor-binding protein-like 1 precursor; insulin-like growth factor-binding-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75426)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071228 cellular response to tumor cell;GO:0001558 regulation of cell growth;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80W15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W93-1", "uniprot_id": [ { "id": "HYDIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W93", "type": "external" } ], "mass": 581523.0, "length": 5154, "protein_name": "Axonemal central pair apparatus protein HYDIN", "gene_name": "Hydin", "organism": "Mouse", "refseq_name": "hydrocephalus-inducing protein", "refseq_ac": [ { "id": "NP_766504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766504", "type": "external" } ], "gene_names_uniprotkb": "Hydin; Hy3", "gene_names_refseq": "1700034M11Rik; 4930545D19Rik; 4932703P14; 672398; A830061H17; AC069308.21gm4; Gm9558; Hydin; hy-3; hy3; hyrh", "protein_names_uniprotkb": "Axonemal central pair apparatus protein HYDIN; Hydrocephalus-inducing protein; Protein Hy-3", "protein_names_refseq": "hydrocephalus 3; hydrocephalus-inducing protein; protein Hy-3", "tax_id": 10090, "disease": "primary ciliary dyskinesia 5 (Disease Ontology:DOID:0110617); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:244653)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12719380;17296793;18250199;25428506;30084848;30089752;30535028;31219806;32072696;32376282;34203471;34428180;35820727;40885482", "class_list": "", "function": "A domain with homology to caldesmon, an actin-binding protein, suggests an interaction with the cytoskeleton., [RefSeq, PubMed]; HYDIN loss-of-function inhibits GATA4 expression and enhances atrial septal defect risk., [RefSeq, PubMed]; It plays a role in sperm motility., [RefSeq, PubMed]; Required for ciliary motility (PubMed:18250199). Required for localization of SPEF2 to the ciliary axoneme in ciliated respiratory epithelial cells (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ06;Q68ED1;Q8BRL9;Q8CDF4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:1990718 axonemal central pair projection", "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0007420 brain development;GO:0021591 ventricular system development;GO:0003341 cilium movement;GO:0002064 epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80W93-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XF5-1", "uniprot_id": [ { "id": "I22R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XF5", "type": "external" } ], "mass": 26613.0, "length": 230, "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "Il22ra2", "organism": "Mouse", "refseq_name": "interleukin-22 receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_839989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839989", "type": "external" } ], "gene_names_uniprotkb": "Il22ra2", "gene_names_refseq": "CRF2-10; CRF2-s1; CRF2X; Il-22bp; Il22ra2", "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-2; CRF2-S1; Cytokine receptor family type 2, soluble 1; IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22BP; Interleukin-22-binding protein; ZcytoR16", "protein_names_refseq": "IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; IL22BP; cytokine receptor family II soluble 1; cytokine receptor family type 2, soluble 1; interleukin-22 receptor subunit alpha-2 precursor; interleukin-22 receptor subunit alpha-2; interleukin-22-binding protein; zcytoR16", "tax_id": 10090, "disease": "", "pathway": " (mmu:237310); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12700595;15201862;19285080;23075849;33207209;36108991;37211203;38101567;38687788", "class_list": "", "function": "Cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes, [RefSeq, PubMed]; Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens., [RefSeq, PubMed]; Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders., [RefSeq, PubMed]; Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues., [RefSeq, PubMed]; IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury., [RefSeq, PubMed]; IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice., [RefSeq, PubMed]; Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses., [UniProtKB, PubMed]; The IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU14;Q7TNI5", "ec_number_list": [], "go_molecular_function": "GO:0042017 interleukin-22 binding;GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0140368 decoy receptor complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway;GO:0042509 regulation of tyrosine phosphorylation of STAT protein", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80XF5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XZ4-1", "uniprot_id": [ { "id": "I22R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XZ4", "type": "external" } ], "mass": 63795.0, "length": 581, "protein_name": "Interleukin-22 receptor subunit alpha-1", "gene_name": "Il22ra1", "organism": "Mouse", "refseq_name": "interleukin-22 receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_839988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839988", "type": "external" } ], "gene_names_uniprotkb": "Il22ra1", "gene_names_refseq": "9130219A07Rik; IL-22R; Il22ra1; Il22r", "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-1; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1", "protein_names_refseq": "IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; interleukin-22 receptor alpha chain; interleukin-22 receptor subunit alpha-1 precursor; interleukin-22 receptor subunit alpha-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230828); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12618864;20971950;24742671", "class_list": "", "function": "Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation., [UniProtKB, PubMed]; Genomic structure and inducible expression of the IL-22 receptor alpha chain., [RefSeq, PubMed]; This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RU51;Q3URP9", "ec_number_list": [], "go_molecular_function": "GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0030876 interleukin-20 receptor complex", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80XZ4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812F3-1", "uniprot_id": [ { "id": "HYAL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q812F3", "type": "external" } ], "mass": 60808.0, "length": 526, "protein_name": "Hyaluronidase-5", "gene_name": "Hyal5", "organism": "Mouse", "refseq_name": "hyaluronidase-5 isoform a precursor", "refseq_ac": [ { "id": "NP_083233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083233", "type": "external" } ], "gene_names_uniprotkb": "Hyal5", "gene_names_refseq": "4933439A12Rik; Hyal5", "protein_names_uniprotkb": "Hyaluronidase-5; 3.2.1.35; Hyal-5; Hyaluronoglucosaminidase-5", "protein_names_refseq": "hyal-5; hyaluronidase Hyal-5; hyaluronidase PH-20; hyaluronidase-5 isoform a precursor; hyaluronidase-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74468); (R-MMU-2160916); (R-MMU-2534343)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16330764;16925524;19605784;19926939;31670981", "class_list": "glycogene;glycosylhydrolase", "function": "A comparative analysis between WT and Spam1/Hyal5 dKO epididymal sperm revealed that the absence of these 2 sperm Hyals resulted in a marked accumulation of sperm on the outside of the cumulus-oocyte complex., [RefSeq, PubMed]; Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments (PubMed:16330764, PubMed:16925524, PubMed:19605784). Does not appear to be essential for fertilization (PubMed:19605784)., [UniProtKB, PubMed, PubMed, PubMed]; Mouse SPAM1 and HYAL5 but not HYALP1 proteins exhibit hyaluronidase activity at neutral pH., [RefSeq, PubMed]; The HYAL5-deficient female mice were fully fertile and yielded normal litter sizes. HYAL5-deficient epididymal sperm is functionally normal. Thus, HYAL5 may be dispensable for fertilization., [RefSeq, PubMed]; The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase HYAL5 may not be required for fertilization, at least in the mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0007341 penetration of zona pellucida;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q812F3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFZ6-1", "uniprot_id": [ { "id": "IDI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFZ6", "type": "external" } ], "mass": 26665.0, "length": 227, "protein_name": "Isopentenyl-diphosphate delta-isomerase 2", "gene_name": "Idi2", "organism": "Mouse", "refseq_name": "isopentenyl-diphosphate delta-isomerase 2", "refseq_ac": [ { "id": "NP_796171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796171", "type": "external" } ], "gene_names_uniprotkb": "Idi2; Gm9745", "gene_names_refseq": "4833405L16Rik; IPPI2; Idi2", "protein_names_uniprotkb": "Isopentenyl-diphosphate delta-isomerase 2; 5.3.3.2; IPP isomerase 2; IPPI2; Isopentenyl pyrophosphate isomerase 2", "protein_names_refseq": "IPP isomerase 2; isopentenyl diphosphate delta-isomerase type 2; isopentenyl pyrophosphate isomerase 2; isopentenyl-diphosphate delta-isomerase 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:320581); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14629038", "class_list": "", "function": "Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)., [UniProtKB, UniProtKB]; Significant positive fitness effect of IDI2, revealed by the pattern of sequence conservation, as well as its specific expression pattern underscores the importance of the IDI gene duplication, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZF0", "ec_number_list": [ { "id": "5.3.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.2", "type": "external" } ], "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0009240 isopentenyl diphosphate biosynthetic process;GO:0050992 dimethylallyl diphosphate biosynthetic process;GO:0046490 isopentenyl diphosphate metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BFZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH06-1", "uniprot_id": [ { "id": "I17RE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH06", "type": "external" } ], "mass": 70833.0, "length": 637, "protein_name": "Interleukin-17 receptor E", "gene_name": "Il17re", "organism": "Mouse", "refseq_name": "interleukin-17 receptor E isoform 2", "refseq_ac": [ { "id": "NP_001029201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029201", "type": "external" } ], "gene_names_uniprotkb": "Il17re", "gene_names_refseq": "IL-17RE; Il17re; Il25r", "protein_names_uniprotkb": "Interleukin-17 receptor E; IL-17 receptor E; IL-17RE", "protein_names_refseq": "IL-17 receptor E; interleukin-17 receptor E isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57890)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16310341;21750661;21982598;21993848;21993849;32641167;34428180;35144761;37235960", "class_list": "", "function": "Clinical significance of Interleukin 17 receptor E in diabetic nephropathy., [RefSeq, PubMed]; IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IkappaBzeta, in Th17 cells to potentiate the Th17 cell response, [RefSeq, PubMed]; Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model., [RefSeq, PubMed]; Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors., [UniProtKB, PubMed, PubMed, PubMed]; The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3I5F0;Q6NSU9;Q8C5D0;Q8K4C1;Q8R335", "ec_number_list": [], "go_molecular_function": "GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BH06-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMJ3-1", "uniprot_id": [ { "id": "IF1AX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMJ3", "type": "external" } ], "mass": 16460.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 1A, X-chromosomal", "gene_name": "Eif1ax", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 1A, X-chromosomal", "refseq_ac": [ { "id": "NP_079713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079713", "type": "external" } ], "gene_names_uniprotkb": "Eif1ax; Eif1ay", "gene_names_refseq": "1500010B24Rik; Eif1ax; Eif1ay; eIF-4C", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 1A, X-chromosomal; Eukaryotic translation initiation factor 4C; eIF-1A X isoform; eIF-4C; eIF1A X isoform", "protein_names_refseq": "eIF1A X isoform; eukaryotic translation initiation factor 1A, X-chromosomal; eukaryotic translation initiation factor 1A, Y-linked; eukaryotic translation initiation factor 4C", "tax_id": 10090, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:66235); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY50;Q6ZWL8;Q8BJZ2;Q8BMH8;Q9CSL9", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex", "go_biological_process": "GO:0006413 translational initiation;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BMJ3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPC6-1", "uniprot_id": [ { "id": "IDHG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPC6", "type": "external" } ], "mass": 43850.0, "length": 396, "protein_name": "Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "gene_name": "", "organism": "Mouse", "refseq_name": "probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "refseq_ac": [ { "id": "NP_766489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766489", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933405O20Rik", "protein_names_uniprotkb": "Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Isocitric dehydrogenase subunit gamma 2; NAD(+)-specific ICDH subunit gamma 2", "protein_names_refseq": "NAD(+)-specific ICDH subunit gamma 2; isocitric dehydrogenase subunit gamma 2; probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (mmu:243996)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18614015;31616917", "class_list": "", "function": "Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BPC6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24668-1", "uniprot_id": [ { "id": "MPRD_MOUSE", "url": "https://www.uniprot.org/uniprot/P24668", "type": "external" } ], "mass": 31172.0, "length": 278, "protein_name": "Cation-dependent mannose-6-phosphate receptor", "gene_name": "M6pr", "organism": "Mouse", "refseq_name": "cation-dependent mannose-6-phosphate receptor precursor", "refseq_ac": [ { "id": "NP_034879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034879", "type": "external" } ], "gene_names_uniprotkb": "M6pr; 46mpr", "gene_names_refseq": "CD-MPR; M6pr; Mpr46", "protein_names_uniprotkb": "Cation-dependent mannose-6-phosphate receptor; 46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; CD-MPR; MPR 46", "protein_names_refseq": "46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; MPR 46; cation-dependent mannose-6-phosphate receptor precursor; cation-dependent mannose-6-phosphate receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17113); (R-MMU-432720); (R-MMU-6811440); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9840310)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;1376319;1645352;1647783;1848553;19144319;19349973;19656770;20407205;22761827;26495903;28252385;30899004;31219806;34428180", "class_list": "glycogene", "function": "Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5. Publication Status: Online-Only, [RefSeq, PubMed]; Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice, [RefSeq, PubMed]; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex., [UniProtKB]; We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 8796, "biomarker_type": "", "glycan_count": 21, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0005770 late endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006622 protein targeting to lysosome;GO:0007041 lysosomal transport;GO:0033299 secretion of lysosomal enzymes", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P24668-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07113-1", "uniprot_id": [ { "id": "MPRI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07113", "type": "external" } ], "mass": 273815.0, "length": 2483, "protein_name": "Cation-independent mannose-6-phosphate receptor", "gene_name": "Igf2r", "organism": "Mouse", "refseq_name": "cation-independent mannose-6-phosphate receptor precursor", "refseq_ac": [ { "id": "NP_034645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034645", "type": "external" } ], "gene_names_uniprotkb": "Igf2r", "gene_names_refseq": "CD222; CI-MPR; Igf2r; M6P/IGF2R; Mpr300", "protein_names_uniprotkb": "Cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; CI-MPR; IGF-II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300", "protein_names_refseq": "300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; IGF-II/CI-MPR; M6P/IGF2 receptor; M6PR; MPR 300; cation-independent MPR; cation-independent mannose-6-phosphate receptor precursor; cation-independent mannose-6-phosphate receptor; insulin-like growth factor II receptor; mannose-6-phosphate receptor, cation independent", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colon carcinoma (Disease Ontology:DOID:1520); nephroblastoma (Disease Ontology:DOID:2154); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); in situ carcinoma (Disease Ontology:DOID:8719); breast carcinoma in situ (Disease Ontology:DOID:8791); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16004); (R-MMU-432722); (R-MMU-6798695); (R-MMU-6811440); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 6, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;16075062;17242355;1848553;18630941;19131326;19144319;19349973;19656770;20173027;20485683;21183079;24129315;25605945;30899004;31219806;34428180;35984892;36210013;37507081;37828378;8188212;8194771;8226743;8462104;8584025", "class_list": "glycogene", "function": "Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 16, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 18, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 18, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 18, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 126, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 12, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q61822;Q6LED1", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0001965 G-protein alpha-subunit binding;GO:0005520 insulin-like growth factor binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen", "go_biological_process": "GO:0001889 liver development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "Q07113-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGT6-1", "uniprot_id": [ { "id": "MILK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGT6", "type": "external" } ], "mass": 94079.0, "length": 870, "protein_name": "MICAL-like protein 1", "gene_name": "Micall1", "organism": "Mouse", "refseq_name": "MICAL-like protein 1", "refseq_ac": [ { "id": "NP_803412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803412", "type": "external" } ], "gene_names_uniprotkb": "Micall1; D15Mit260; Kiaa1668; Mirab13", "gene_names_refseq": "D15Mit260; D15N2e; EST573322; EST820961; MIRab13; Micall1; mKIAA1668", "protein_names_uniprotkb": "MICAL-like protein 1; MIRab13; Molecule interacting with Rab13", "protein_names_refseq": "MICAL-like protein 1; microtubule associated monoxygenase, calponin and LIM domain containing -like 1; molecule interacting with Rab13", "tax_id": 10090, "disease": "", "pathway": " (mmu:27008)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18094055;21183079;21750661;23572513;33972531", "class_list": "", "function": "Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane. Also involved in cargo protein delivery to the plasma membrane (By similarity). May indirectly play a role in neurite outgrowth (PubMed:23572513). During sprouting angiogenesis, in complex with PACSIN2 and EHD4, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (PubMed:33972531). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QKJ4;Q8BJ60", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005929 cilium;GO:0030054 cell junction", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CD10-1", "uniprot_id": [ { "id": "MICU2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CD10", "type": "external" } ], "mass": 49476.0, "length": 432, "protein_name": "Calcium uptake protein 2, mitochondrial", "gene_name": "Micu2", "organism": "Mouse", "refseq_name": "calcium uptake protein 2, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_082919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082919", "type": "external" } ], "gene_names_uniprotkb": "Micu2; Efha1", "gene_names_refseq": "1110008L20Rik; 4833427E09Rik; Efha1; Micu2; Smhs2", "protein_names_uniprotkb": "Calcium uptake protein 2, mitochondrial; EF-hand domain-containing family member A1", "protein_names_refseq": "EF hand domain family A1; EF-hand domain-containing family member A1; calcium uptake protein 2, mitochondrial isoform 1; calcium uptake protein 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68514); (R-MMU-8949215); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "23409044;24560927;25428506;28273446;29073106;30755530;31361958;33932586;39163336", "class_list": "", "function": "A possible role for tissue-specific stoichiometry between the Ca(2+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated., [RefSeq, PubMed]; Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart., [RefSeq, PubMed]; Micu2 role in regulating angiotensin II-mediated hypertensive responses that are critical in protecting the abdominal aorta from injury., [RefSeq, PubMed]; Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJU4;Q8K0K2;Q9CUR8", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CD10-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K273-1", "uniprot_id": [ { "id": "EMC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K273", "type": "external" } ], "mass": 14677.0, "length": 131, "protein_name": "ER membrane protein complex subunit 5", "gene_name": "Mmgt1", "organism": "Mouse", "refseq_name": "ER membrane protein complex subunit 5", "refseq_ac": [ { "id": "NP_666346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666346", "type": "external" } ], "gene_names_uniprotkb": "Mmgt1; Emc5; Tmem32", "gene_names_refseq": "9630048L06Rik; Emc5; Mir5116; Mmgt1; Tmem32; mir-5116", "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Membrane magnesium transporter 1; Transmembrane protein 32", "protein_names_refseq": "ER membrane protein complex subunit 5; transmembrane protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:236792)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18057121;21183079;25428506", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). May be involved Mg(2+) transport (PubMed:18057121)., [UniProtKB, PubMed, UniProtKB]; These experiments suggest that MMgT proteins may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells.(MMgT1 PROTEIN, MOUSE), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7UH87", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015087 cobalt ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0006812 monoatomic cation transport;GO:0006825 copper ion transport;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K273-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ65-1", "uniprot_id": [ { "id": "MTAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ65", "type": "external" } ], "mass": 31062.0, "length": 283, "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "organism": "Mouse", "refseq_name": "S-methyl-5'-thioadenosine phosphorylase", "refseq_ac": [ { "id": "NP_077753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077753", "type": "external" } ], "gene_names_uniprotkb": "Mtap", "gene_names_refseq": "1300019I21Rik; MSAP; Mtap", "protein_names_uniprotkb": "S-methyl-5'-thioadenosine phosphorylase; 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MTAP", "protein_names_refseq": "5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; S-methyl-5'-thioadenosine phosphorylase", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)", "pathway": " (mmu:66902); (R-MMU-1237112)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12824877;18237276;23806337;23840755;24324622;24788674;25153642;26819315;28528544;37453647;37507081", "class_list": "", "function": "Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates., [UniProtKB, HAMAP, PubMed]; Data demonstrate that MTAP deficiency leads to accumulation of MTA inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver., [RefSeq, PubMed]; Germline Mutations in Mtap is associated with lymphomagenesis. Publication Status: Online-Only, [RefSeq, PubMed]; MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB activation and apoptosis in hepatic stellate cells. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJS4", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "4.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.-", "type": "external" } ], "go_molecular_function": "GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006166 purine ribonucleoside salvage;GO:0032259 methylation;GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CQ65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQE4-1", "uniprot_id": [ { "id": "NEMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQE4", "type": "external" } ], "mass": 49817.0, "length": 437, "protein_name": "Nuclear envelope integral membrane protein 1", "gene_name": "Nemp1", "organism": "Mouse", "refseq_name": "nuclear envelope integral membrane protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106682", "type": "external" } ], "gene_names_uniprotkb": "Nemp1; Kiaa0286; Tmem194a; Tmem194", "gene_names_refseq": "Nemp1; Tmem194a; Tmem194", "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 1", "protein_names_refseq": "nuclear envelope integral membrane protein 1 isoform 1 precursor; transmembrane protein 194A", "tax_id": 10090, "disease": "", "pathway": " (mmu:210035)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;25946333;30084848;32923640;36215313", "class_list": "", "function": "Nemp1 represents a new type of RanGTP-binding protein. Publication Status: Online-Only, [RefSeq, PubMed]; The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (PubMed:32923640). Essential for normal erythropoiesis (PubMed:36215313). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (PubMed:36215313)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0071763 nuclear membrane organization;GO:0043131 erythrocyte enucleation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6ZQE4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19246-1", "uniprot_id": [ { "id": "NFH_MOUSE", "url": "https://www.uniprot.org/uniprot/P19246", "type": "external" } ], "mass": 116994.0, "length": 1090, "protein_name": "Neurofilament heavy polypeptide", "gene_name": "Nefh", "organism": "Mouse", "refseq_name": "neurofilament heavy polypeptide", "refseq_ac": [ { "id": "NP_035034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035034", "type": "external" } ], "gene_names_uniprotkb": "Nefh; Kiaa0845; Nfh", "gene_names_refseq": "NF-H; NF200; Nefh; Nfh; mKIAA0845", "protein_names_uniprotkb": "Neurofilament heavy polypeptide; 200 kDa neurofilament protein; NF-H; Neurofilament triplet H protein", "protein_names_refseq": "200 kDa neurofilament protein; neurofilament 200kDa; neurofilament heavy polypeptide; neurofilament triplet H protein", "tax_id": 10090, "disease": "autoimmune optic neuritis (Disease Ontology:DOID:0040089); congenital hypothyroidism (Disease Ontology:DOID:0050328); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Charcot-Marie-Tooth disease axonal type 2CC (Disease Ontology:DOID:0110180); sciatic neuropathy (Disease Ontology:DOID:11446); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); optic neuritis (Disease Ontology:DOID:1210); hypothyroidism (Disease Ontology:DOID:1459); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725); neuromyelitis optica (Disease Ontology:DOID:8869); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (mmu:380684)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16452087;18353774;21183079;22645316;22723690;3145094;3220257;32848054;33300544;40021952;40684658;40885482", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 59, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A1E2H9;Q5SVF6;Q61959", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0048936 peripheral nervous system neuron axonogenesis;GO:1990830 cellular response to leukemia inhibitory factor;GO:0000226 microtubule cytoskeleton organization;GO:0060052 neurofilament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P19246-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG18-1", "uniprot_id": [ { "id": "NECA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG18", "type": "external" } ], "mass": 40934.0, "length": 352, "protein_name": "N-terminal EF-hand calcium-binding protein 1", "gene_name": "Necab1", "organism": "Mouse", "refseq_name": "N-terminal EF-hand calcium-binding protein 1", "refseq_ac": [ { "id": "NP_848732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848732", "type": "external" } ], "gene_names_uniprotkb": "Necab1; Efcbp1", "gene_names_refseq": "1700003H21Rik; Efcbp1; Necab1; STIP-1", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 1; EF-hand calcium-binding protein 1", "protein_names_refseq": "EF-hand calcium-binding protein 1; N-terminal EF-hand calcium-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69352)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12044471;21183079;23850650;37863964", "class_list": "", "function": "Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic beta-cells. Publication Status: Online-Only, [RefSeq, PubMed]; The genes for the three Necab's, including Necab-1, were expressed in specific, non-overlapping areas of the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80W91", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0001835 blastocyst hatching;GO:0042984 regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BG18-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0W6-1", "uniprot_id": [ { "id": "NFIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0W6", "type": "external" } ], "mass": 24914.0, "length": 221, "protein_name": "NEDD4 family-interacting protein 1", "gene_name": "Ndfip1", "organism": "Mouse", "refseq_name": "NEDD4 family-interacting protein 1", "refseq_ac": [ { "id": "NP_075372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075372", "type": "external" } ], "gene_names_uniprotkb": "Ndfip1; N4wbp5", "gene_names_refseq": "0610010M22Rik; N4wbp5; Ndfip1", "protein_names_uniprotkb": "NEDD4 family-interacting protein 1; NEDD4 WW domain-binding protein 5", "protein_names_refseq": "NEDD4 WW domain-binding protein 5; NEDD4 family-interacting protein 1; Nedd4 WW binding protein 5", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (mmu:65113)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11042109;11748237;15240697;16075062;16822981;17137798;18250455;18776082;18819914;19706893;20962770;21750661;23897647;24520172;25631046;25632008;25801959;26319551;26495903;26740625;27088444;28011936;28051111;31219806;32152506;34428180;36617825;37023120;38365133", "class_list": "", "function": "Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (PubMed:11748237, PubMed:17137798, PubMed:20962770). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (PubMed:28051111). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (PubMed:27088444). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (PubMed:24520172, PubMed:28051111). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (By similarity). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (By similarity). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (By similarity). Important for normal development of dendrites and dendritic spines in cortex (PubMed:23897647). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (PubMed:25632008). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (By similarity). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. Publication Status: Online-Only, [RefSeq, PubMed]; Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease., [RefSeq, PubMed]; Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQH8", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005938 cell cortex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0048302 regulation of isotype switching to IgG isotypes;GO:0010629 negative regulation of gene expression;GO:0006879 intracellular iron ion homeostasis;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8R0W6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZP9-1", "uniprot_id": [ { "id": "NECA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZP9", "type": "external" } ], "mass": 43441.0, "length": 389, "protein_name": "N-terminal EF-hand calcium-binding protein 2", "gene_name": "Necab2", "organism": "Mouse", "refseq_name": "N-terminal EF-hand calcium-binding protein 2", "refseq_ac": [ { "id": "NP_473436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473436", "type": "external" } ], "gene_names_uniprotkb": "Necab2; Efcbp2", "gene_names_refseq": "Efcbp2; Necab2", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 2; EF-hand calcium-binding protein 2; Neuronal calcium-binding protein 2", "protein_names_refseq": "EF hand calcium binding protein 2; N-terminal EF-hand calcium-binding protein 2; neuronal calcium binding 2; neuronal calcium-binding protein 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:117148)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11641222;23850650;24129315;26843217", "class_list": "", "function": "May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation., [UniProtKB, UniProtKB]; The genes for the three Necab's, including Necab-2, were expressed in specific, non-overlapping areas of the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZI4;Q8C492", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031802 type 5 metabotropic glutamate receptor binding;GO:0005509 calcium ion binding;GO:0031687 A2A adenosine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0098794 postsynapse", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0060168 positive regulation of adenosine receptor signaling pathway;GO:0042984 regulation of amyloid precursor protein biosynthetic process;GO:1900451 positive regulation of glutamate receptor signaling pathway;GO:1904021 negative regulation of G protein-coupled receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYF9-1", "uniprot_id": [ { "id": "NDRG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYF9", "type": "external" } ], "mass": 41555.0, "length": 375, "protein_name": "Protein NDRG3", "gene_name": "Ndrg3", "organism": "Mouse", "refseq_name": "protein NDRG3 isoform 2", "refseq_ac": [ { "id": "NP_038893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038893", "type": "external" } ], "gene_names_uniprotkb": "Ndrg3; Ndr3", "gene_names_refseq": "4833415O14Rik; Ndr3; Ndrg3", "protein_names_uniprotkb": "Protein NDRG3; N-myc downstream-regulated gene 3 protein; Protein Ndr3", "protein_names_refseq": "N-myc downstream regulated 3; N-myc downstream-regulated gene 3 protein; protein NDRG3 isoform 2; protein NDRG3; protein Ndr3", "tax_id": 10090, "disease": "", "pathway": " (mmu:29812)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10581191;17242355;21183079;21636852;25428506;25605945;28528544;30084848;31219806;34428180;35820727;37172727", "class_list": "", "function": "Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0046697 decidualization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9QYF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTS5-1", "uniprot_id": [ { "id": "TEN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTS5", "type": "external" } ], "mass": 306468.0, "length": 2764, "protein_name": "Teneurin-2", "gene_name": "Tenm2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tenm2; Kiaa1127; Odz2; Tnm2", "gene_names_refseq": "", "protein_names_uniprotkb": "Teneurin-2; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10225957;10588872;10625539;12000766;12915301;21183079;21750661;30792275;30899004;33109704;33300544;34428180", "class_list": "", "function": "Induces gene transcription inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 15, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 15, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 15, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q5NBW7;Q5NBW8;Q80TJ0;Q9JLC0;Q9QYZ1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q9WTS5-1", "record_type": "protein", "filter_code": "0000000.1000100.001000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80313-1", "uniprot_id": [ { "id": "TCPH_MOUSE", "url": "https://www.uniprot.org/uniprot/P80313", "type": "external" } ], "mass": 59652.0, "length": 544, "protein_name": "T-complex protein 1 subunit eta", "gene_name": "Cct7", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit eta", "refseq_ac": [ { "id": "NP_031664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031664", "type": "external" } ], "gene_names_uniprotkb": "Cct7; Ccth", "gene_names_refseq": "Cct7; Ccth; Cctz", "protein_names_uniprotkb": "T-complex protein 1 subunit eta; 3.6.1.-; CCT-eta; TCP-1-eta", "protein_names_refseq": "CCT-eta; T-complex protein 1 subunit eta; TCP-1-eta; chaperonin containing Tcp1, subunit 7 (eta); chaperonin containing t-complex subunit eta; chaperonin subunit 7 (eta)", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (mmu:12468); (R-MMU-390471); (R-MMU-6814122); (R-MMU-9013418); (R-MMU-9013422)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10336634;18299400;20173027;21750661;21880732;21952136;23806337;24129315;25428506;26495903;29187734;30084848;31219806;32152506;33300544;33649389;34428180;34887587;35820727;37828378;39627609;39927985;7953530", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P80313-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VL8-1", "uniprot_id": [ { "id": "TE2IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VL8", "type": "external" } ], "mass": 43353.0, "length": 393, "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "gene_name": "Terf2ip", "organism": "Mouse", "refseq_name": "telomeric repeat-binding factor 2-interacting protein 1", "refseq_ac": [ { "id": "NP_065609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065609", "type": "external" } ], "gene_names_uniprotkb": "Terf2ip; MNCb-0448; MNCb-0628; Rap1", "gene_names_refseq": "Rap1; Terf2ip", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1", "protein_names_refseq": "RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein Rap1; repressor/activator protein 1 homolog; telomeric repeat-binding factor 2-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57321); (R-MMU-110330); (R-MMU-110331); (R-MMU-171319); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174430); (R-MMU-174437); (R-MMU-2559586); (R-MMU-9670095)", "pathway_count": 11, "publication_count": 13, "publication_id_list": "14659874;15345747;17242355;20339076;20622869;20622870;21183079;31219806;33754023;34428180;35210222;36441670;38697492", "class_list": "", "function": "Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes., [UniProtKB, PubMed, PubMed, PubMed]; Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARalpha signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states., [RefSeq, PubMed]; Terf2ip deficiency accelerates non-alcoholic steatohepatitis through regulating lipophagy and fatty acid oxidation via Sirt1/AMPK pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YWE8;Q543F4;Q8C2Y1;Q9JJE8;Q9JJE9", "ec_number_list": [], "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042162 telomeric DNA binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000783 nuclear telomere cap complex", "go_biological_process": "GO:0032205 negative regulation of telomere maintenance;GO:0010833 telomere maintenance via telomere lengthening;GO:0032204 regulation of telomere maintenance;GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91VL8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XQ2-1", "uniprot_id": [ { "id": "TBCD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XQ2", "type": "external" } ], "mass": 91837.0, "length": 815, "protein_name": "TBC1 domain family member 5", "gene_name": "Tbc1d5", "organism": "Mouse", "refseq_name": "TBC1 domain family member 5 isoform b", "refseq_ac": [ { "id": "NP_001272922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272922", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d5", "gene_names_refseq": "1600014N05Rik; Tbc1d5", "protein_names_uniprotkb": "TBC1 domain family member 5", "protein_names_refseq": "TBC1 domain family member 5 isoform b", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72238)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21750661;21952136;24129315;25428506;28602638;30084848;34428180;34678516;35820727;38848175", "class_list": "", "function": "Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models., [RefSeq, PubMed]; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity)., [UniProtKB, UniProtKB]; TBC1D5 shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PZJ9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0035612 AP-2 adaptor complex binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0005776 autophagosome;GO:0030904 retromer complex", "go_biological_process": "GO:0015031 protein transport;GO:0042594 response to starvation;GO:0016236 macroautophagy;GO:0002092 positive regulation of receptor internalization;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80XQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIV8-1", "uniprot_id": [ { "id": "TBCE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIV8", "type": "external" } ], "mass": 59086.0, "length": 524, "protein_name": "Tubulin-specific chaperone E", "gene_name": "Tbce", "organism": "Mouse", "refseq_name": "tubulin-specific chaperone E", "refseq_ac": [ { "id": "NP_848027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848027", "type": "external" } ], "gene_names_uniprotkb": "Tbce", "gene_names_refseq": "2610206D02Rik; C530005D02Rik; Tbce; pmn", "protein_names_uniprotkb": "Tubulin-specific chaperone E; Tubulin-folding cofactor E", "protein_names_refseq": "progressive motor neuropathy; tubulin-folding cofactor E; tubulin-specific chaperone E", "tax_id": 10090, "disease": "hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); Kenny-Caffey syndrome type 1 (Disease Ontology:DOID:0080722); hypoparathyroidism (Disease Ontology:DOID:11199)", "pathway": " (mmu:70430)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12389029;17184771;21750661;22645316;27488538;35820727", "class_list": "", "function": "This gene encodes a tubulin binding cofactor that participates in microtubule dynamics. A mouse model of progressive motor neuropathy (pmn) was discovered to harbor a single amino acid deletion in this gene. Mice that are homozygous for pmn allele exhibit progressive atrophy and premature death due to respiratory failure. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]; This study reported that reduced expression of the tubulin-specific chaperone TBCE leads to defective microtubule polymerization and impaired microtubule-dependent axonal transport in sensory DRG neurons of pmn mice., [RefSeq, PubMed]; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation (PubMed:12389029, PubMed:17184771). Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0048936 peripheral nervous system neuron axonogenesis;GO:0007409 axonogenesis;GO:0008344 adult locomotory behavior;GO:0009791 post-embryonic development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CIV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VP0-1", "uniprot_id": [ { "id": "TCPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VP0", "type": "external" } ], "mass": 130266.0, "length": 1166, "protein_name": "Tectonin beta-propeller repeat-containing protein 1", "gene_name": "Tecpr1", "organism": "Mouse", "refseq_name": "tectonin beta-propeller repeat-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_081686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081686", "type": "external" } ], "gene_names_uniprotkb": "Tecpr1; Kiaa1358", "gene_names_refseq": "2210010N04Rik; Tecpr1; mKIAA1358", "protein_names_uniprotkb": "Tectonin beta-propeller repeat-containing protein 1", "protein_names_refseq": "tectonin beta-propeller repeat-containing protein 1 isoform 1; tectonin beta-propeller repeat-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70381)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21575909;30016717", "class_list": "", "function": "Although Tecpr1-deficient mice appear normal, Tecpr1-deficient mouse embryo fibroblasts were defective for selective autophagy and supported increased intracellular multiplication of Shigella., [RefSeq, PubMed]; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHA3;Q8R3E0;Q99KQ5;Q9CVC6", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005654 nucleoplasm;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:1901096 regulation of autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80VP0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925J9-1", "uniprot_id": [ { "id": "MED1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925J9", "type": "external" } ], "mass": 167141.0, "length": 1575, "protein_name": "Mediator of RNA polymerase II transcription subunit 1", "gene_name": "Med1", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 1 isoform 3", "refseq_ac": [ { "id": "NP_001073587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073587", "type": "external" } ], "gene_names_uniprotkb": "Med1; Crsp210; Drip205; Pbp; Pparbp; Trap220; Trip2", "gene_names_refseq": "CRSP210; DRIP205; Med1; PBP; Pparbp; TRAP220; TRIP-2; l11Jus15", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 1; Mediator complex subunit 1; PBP; PPAR-binding protein; Peroxisome proliferator-activated receptor-binding protein; TR-interacting protein 2; TRIP-2; Thyroid hormone receptor-associated protein complex 220 kDa component; Thyroid receptor-interacting protein 2; Trap220", "protein_names_refseq": "PPAR-binding protein; Ppar binding protein; TR-interacting protein 2; mediator of RNA polymerase II transcription subunit 1 isoform 3; mediator of RNA polymerase II transcription subunit 1; peroxisome proliferator-activated receptor-binding protein; thyroid hormone receptor-associated protein complex 220 kDa component; thyroid receptor-interacting protein 2", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:19014); (R-MMU-383280); (R-MMU-400206); (R-MMU-9018519); (R-MMU-9707564)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10882104;11266503;11471062;11867769;12037571;12709428;14500757;14636573;15150259;15340084;15528208;16137621;17132730;17525332;21183079;21750661;22645316;24043798;25644604;25644605;34428180;36852467;40885482;40997131;9325263", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2A526;A2A528;O88323;Q3UHV0;Q6AXD5;Q8BW37;Q8BX19;Q8VDQ7;Q925K0", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0060745 mammary gland branching involved in pregnancy;GO:0035162 embryonic hemopoiesis;GO:2001141 regulation of RNA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q925J9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGC0-1", "uniprot_id": [ { "id": "HTSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGC0", "type": "external" } ], "mass": 86240.0, "length": 757, "protein_name": "17S U2 SnRNP complex component HTATSF1", "gene_name": "Htatsf1", "organism": "Mouse", "refseq_name": "17S U2 SnRNP complex component HTATSF1", "refseq_ac": [ { "id": "NP_082518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082518", "type": "external" } ], "gene_names_uniprotkb": "Htatsf1", "gene_names_refseq": "1600023H17Rik; 2600017A12Rik; 2700077B20Rik; Htatsf1; TAT-SF1", "protein_names_uniprotkb": "17S U2 SnRNP complex component HTATSF1; HIV Tat-specific factor 1 homolog", "protein_names_refseq": "17S U2 SnRNP complex component HTATSF1; HIV Tat-specific factor 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72459); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15345747;15485897;17242355;21183079;23806337;24352707;34887587;35820727", "class_list": "", "function": "CA150 FF domains recognize multiple sites within the Tat-SF1 protein conforming to the consensus motif (D/E)(2/5)-F/W/Y-(D/E)(2/5)., [RefSeq, PubMed]; Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop. HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences. Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation. Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites. Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination., [UniProtKB, UniProtKB]; Our results predict sex as a determinant of HIV effects in brain. Increased behavioral deficits in males correlated with glial activation and synaptic damage, both of which are implicated in cognitive/motor impairments in patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVC7;Q1WWK0;Q9CT41;Q9DAU3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140463 chromatin-protein adaptor activity;GO:0160004 poly-ADP-D-ribose modification-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005686 U2 snRNP;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006351 DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJX4-1", "uniprot_id": [ { "id": "MALR1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJX4", "type": "external" } ], "mass": 236194.0, "length": 2123, "protein_name": "MAM and LDL-receptor class A domain-containing protein 1", "gene_name": "Malrd1", "organism": "Mouse", "refseq_name": "MAM and LDL-receptor class A domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001297384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297384", "type": "external" } ], "gene_names_uniprotkb": "Malrd1; Diet1; Gm13318", "gene_names_refseq": "Diet1; Gm13318; Gm13364; Malrd1", "protein_names_uniprotkb": "MAM and LDL-receptor class A domain-containing protein 1", "protein_names_refseq": "MAM and LDL-receptor class A domain-containing protein 1 precursor; MAM and LDL-receptor class A domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102635496)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10744778;23747249;26045262;29295820", "class_list": "", "function": "Diet1 appears to be a control point for the production of fibroblast growth factor 15/19 in enterocytes, and thus a regulator of bile acid and lipid homeostasis., [RefSeq, PubMed]; Diet1-deficient mice exhibited an elevated bile acid pool size and impaired feedback regulation of hepatic Cyp7a1, which encodes the rate-limiting enzyme in bile acid synthesis., [RefSeq, PubMed]; Enhances production and/or transport of FGF15 and thus has a role in regulation of bile acid synthesis., [UniProtKB, PubMed]; Genetic variation in DIET1 may be a determinant of FGF19 secretion levels, and may affect bile acid metabolism in both physiological and pathological conditions, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "R9W764", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0070858 negative regulation of bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AJX4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26645-1", "uniprot_id": [ { "id": "MARCS_MOUSE", "url": "https://www.uniprot.org/uniprot/P26645", "type": "external" } ], "mass": 29661.0, "length": 309, "protein_name": "Myristoylated alanine-rich C-kinase substrate", "gene_name": "Marcks", "organism": "Mouse", "refseq_name": "myristoylated alanine-rich C-kinase substrate", "refseq_ac": [ { "id": "NP_032564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032564", "type": "external" } ], "gene_names_uniprotkb": "Marcks; Macs", "gene_names_refseq": "Macs; Marcks; PKCSL", "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate; MARCKS", "protein_names_refseq": "80K protein; myristoylated alanine-rich C-kinase substrate", "tax_id": 10090, "disease": "Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:17118); (R-MMU-399997)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12577052;1396720;15345747;17242355;1868832;19131326;2006186;20205598;21183079;2384168;24658276;25428506;28011936;30185885;30655546;33725478;37586467;37828378;7588787;8700893;8849678", "class_list": "", "function": "Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3 and stabilizing MARCKS expression in diabetic cardiomyopathy., [RefSeq, PubMed]; Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes. Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation (PubMed:30185885, PubMed:30655546, PubMed:8700893). Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (By similarity). During inflammation, promotes the migration of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:20205598). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (PubMed:30185885). Also plays a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001520 outer dense fiber;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0010976 positive regulation of neuron projection development;GO:0006915 apoptotic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P26645-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54841-1", "uniprot_id": [ { "id": "MAFB_MOUSE", "url": "https://www.uniprot.org/uniprot/P54841", "type": "external" } ], "mass": 35809.0, "length": 323, "protein_name": "Transcription factor MafB", "gene_name": "Mafb", "organism": "Mouse", "refseq_name": "transcription factor MafB", "refseq_ac": [ { "id": "NP_034788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034788", "type": "external" } ], "gene_names_uniprotkb": "Mafb; Krml; Maf1", "gene_names_refseq": "Kreisler; Krml1; Krml; Mafb; kr", "protein_names_uniprotkb": "Transcription factor MafB; Kreisler; Maf-B; Segmentation protein Kr; Transcription factor Maf-1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B", "protein_names_refseq": "Kreisler (maf-related) leucine zipper protein; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; maf-B; segmentation protein Kr; transcription factor Maf-1; transcription factor MafB; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B", "tax_id": 10090, "disease": "Duane retraction syndrome 3 (Disease Ontology:DOID:0061029); multicentric carpotarsal osteolysis syndrome (Disease Ontology:DOID:0111534); Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (mmu:16658)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10383433;10721736;10790365;11823429;14513037;15135046;16443760;16847325;16943423;17360442;17548468;17901057;17977745;18199433;19143053;19440205;25428506;27181683;30084848;30779550;34428180;8001130", "class_list": "", "function": "Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3C8;Q3UPT9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021571 rhombomere 5 development;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P54841-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KL35-1", "uniprot_id": [ { "id": "MAGIX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KL35", "type": "external" } ], "mass": 34771.0, "length": 324, "protein_name": "PDZ domain-containing protein MAGIX", "gene_name": "Magix", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein MAGIX", "refseq_ac": [ { "id": "NP_061302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061302", "type": "external" } ], "gene_names_uniprotkb": "Magix; Pdzx", "gene_names_refseq": "Magix; Pdzx; Sfc18", "protein_names_uniprotkb": "PDZ domain-containing protein MAGIX", "protein_names_refseq": "PDZ domain containing X chromosome; PDZ domain-containing protein MAGIX", "tax_id": 10090, "disease": "", "pathway": " (mmu:54634)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10857745;17242355;21183079;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIG3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4KL35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D992-1", "uniprot_id": [ { "id": "MAJIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D992", "type": "external" } ], "mass": 29175.0, "length": 256, "protein_name": "Membrane-anchored junction protein", "gene_name": "Majin", "organism": "Mouse", "refseq_name": "membrane-anchored junction protein isoform 1", "refseq_ac": [ { "id": "NP_001159391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159391", "type": "external" } ], "gene_names_uniprotkb": "Majin", "gene_names_refseq": "1700123I01Rik; Majin", "protein_names_uniprotkb": "Membrane-anchored junction protein", "protein_names_refseq": "membrane-anchored junction protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:622554)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26548954;30718482;32408858", "class_list": "", "function": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane., [UniProtKB, PubMed]; Study identified meiosis-specific telomere and inner nuclear membrane-binding proteins, telomere repeat-binding bouquet formation protein 2 (TERB2) and membrane-anchored junction protein (MAJIN), which form a complex with TERB1. Erratum:[Cell. 2018 May 3;173(4):1058. doi: 10.1016/j.cell.2018.04.025. PMID: 29727665], [RefSeq, PubMed]; The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans. Publication Status: Online-Only, [RefSeq, PubMed]; The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q4N4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis;GO:1990918 double-strand break repair involved in meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D992-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8A8-1", "uniprot_id": [ { "id": "TEKT5_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8A8", "type": "external" } ], "mass": 62734.0, "length": 557, "protein_name": "Tektin-5", "gene_name": "Tekt5", "organism": "Mouse", "refseq_name": "tektin-5", "refseq_ac": [ { "id": "NP_001277930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277930", "type": "external" } ], "gene_names_uniprotkb": "Tekt5", "gene_names_refseq": "3300001K11Rik; Tekt5", "protein_names_uniprotkb": "Tektin-5", "protein_names_refseq": "tektin-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:70426)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20378928;31208979;36206347;37295417;37865089;37989994", "class_list": "", "function": "Results showed that TEKT5 controls tubulin stability to enhance the growth and survival of cancer cells and to promote sperm morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme (PubMed:20378928, PubMed:37295417, PubMed:37865089, PubMed:37989994). Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A-tubule of the sperm flagellum (PubMed:37295417, PubMed:37865089)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TEKT5 protein was highly expressed in mouse spermatids and was localized in the flagellar accessory structures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D5HP88;Q14BE9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G5E8A8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70323-1", "uniprot_id": [ { "id": "TBX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70323", "type": "external" } ], "mass": 51668.0, "length": 479, "protein_name": "T-box transcription factor TBX1", "gene_name": "Tbx1", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX1 isoform 1", "refseq_ac": [ { "id": "NP_035662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035662", "type": "external" } ], "gene_names_uniprotkb": "Tbx1", "gene_names_refseq": "Tbx1; nmf219", "protein_names_uniprotkb": "T-box transcription factor TBX1; T-box protein 1; Testis-specific T-box protein", "protein_names_refseq": "T-box protein 1; T-box transcription factor TBX1 isoform 1; T-box transcription factor TBX1; testis-specific T-box protein", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); DiGeorge syndrome (Disease Ontology:DOID:11198); hypoparathyroidism (Disease Ontology:DOID:11199); velocardiofacial syndrome (Disease Ontology:DOID:12583); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); epilepsy (Disease Ontology:DOID:1826); acute kidney failure (Disease Ontology:DOID:3021); tetralogy of Fallot (Disease Ontology:DOID:6419); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:21380)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11239417;11242049;11242110;11412027;15385444;15703190;16556915;21177346;21750661;22495305;31412026;7920656;8853987;8878690", "class_list": "", "function": "Transcription factor that plays a key role in cardiovascular development by promoting pharyngeal arch segmentation during embryonic development (PubMed:11239417, PubMed:11242049, PubMed:11242110, PubMed:11412027, PubMed:15703190, PubMed:16556915). Also involved in craniofacial muscle development (PubMed:15385444). Together with NKX2-5, acts as a regulator of asymmetric cardiac morphogenesis by promoting expression of PITX2 (PubMed:16556915). Acts upstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026). Required for hair follicle stem cell self-renewal (PubMed:22495305). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60706;Q99MP0;Q99P22", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0001708 cell fate specification;GO:0048752 semicircular canal morphogenesis;GO:2001054 negative regulation of mesenchymal cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P70323-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70325-1", "uniprot_id": [ { "id": "TBX4_MOUSE", "url": "https://www.uniprot.org/uniprot/P70325", "type": "external" } ], "mass": 61101.0, "length": 552, "protein_name": "T-box transcription factor TBX4", "gene_name": "Tbx4", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX4 isoform a", "refseq_ac": [ { "id": "NP_035666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035666", "type": "external" } ], "gene_names_uniprotkb": "Tbx4", "gene_names_refseq": "3930401C23; Tbx4", "protein_names_uniprotkb": "T-box transcription factor TBX4; T-box protein 4", "protein_names_refseq": "T-box protein 4; T-box transcription factor TBX4 isoform a; T-box transcription factor TBX4", "tax_id": 10090, "disease": "ischiocoxopodopatellar syndrome (Disease Ontology:DOID:0111382); arthropathy (Disease Ontology:DOID:381)", "pathway": " (mmu:21387)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;30084848;8853987;8878690", "class_list": "", "function": "Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AQT9;Q8R5F6", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70325-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80317-1", "uniprot_id": [ { "id": "TCPZ_MOUSE", "url": "https://www.uniprot.org/uniprot/P80317", "type": "external" } ], "mass": 58004.0, "length": 531, "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "Cct6a", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit zeta", "refseq_ac": [ { "id": "NP_033968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033968", "type": "external" } ], "gene_names_uniprotkb": "Cct6a; Cct6; Cctz1; Cctz", "gene_names_refseq": "CCT-zeta-1; CCT-zeta; Cct6a; Cct6; Cctz-1; TCP-1-zeta", "protein_names_uniprotkb": "T-complex protein 1 subunit zeta; 3.6.1.-; CCT-zeta-1; TCP-1-zeta", "protein_names_refseq": "T-complex protein 1 subunit zeta; chaperonin containing TCP-1; chaperonin containing Tcp1, subunit 6a (zeta); chaperonin subunit 6a (zeta)", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:12466); (R-MMU-390471); (R-MMU-6814122); (R-MMU-9013418)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10336634;22645316;23806337;25428506;25605945;28375158;30084848;32152506;33300544;33725478;34428180;34887587;37453647;37507081;39627609;39927985;7953530", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance., [UniProtKB, UniProtKB]; Selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0001669 acrosomal vesicle;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904851 positive regulation of establishment of protein localization to telomere", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P80317-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10400-1", "uniprot_id": [ { "id": "POL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P10400", "type": "external" } ], "mass": 13302.0, "length": 120, "protein_name": "Retrovirus-related Pol polyprotein", "gene_name": "Pol", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pol", "gene_names_refseq": "", "protein_names_uniprotkb": "Retrovirus-related Pol polyprotein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2415714;34428180;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10400-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II04-1", "uniprot_id": [ { "id": "NEBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0II04", "type": "external" } ], "mass": 52201.0, "length": 452, "protein_name": "Nebulette", "gene_name": "Nebl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nebl; Lnebl", "gene_names_refseq": "", "protein_names_uniprotkb": "Nebulette; Actin-binding Z-disk protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:74103)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15004028;21750661;24129315;35822049;36288343;37507081;40885482", "class_list": "", "function": "Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity)., [UniProtKB]; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0005523 tropomyosin binding;GO:0031005 filamin binding;GO:0003779 actin binding", "go_cellular_component": "GO:0001725 stress fiber;GO:0030018 Z disc;GO:0005737 cytoplasm", "go_biological_process": "GO:0071691 cardiac muscle thin filament assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q0II04-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U133-1", "uniprot_id": [ { "id": "ZN746_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U133", "type": "external" } ], "mass": 69821.0, "length": 652, "protein_name": "Zinc finger protein 746", "gene_name": "Zfp746; Znf746", "organism": "Mouse", "refseq_name": "zinc finger protein 746 isoform 1", "refseq_ac": [ { "id": "NP_001156947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156947", "type": "external" } ], "gene_names_uniprotkb": "Zfp746; Znf746; Zfp746", "gene_names_refseq": "2810407L07Rik; Zfp746; Znf746", "protein_names_uniprotkb": "Zinc finger protein 746", "protein_names_refseq": "zinc finger protein 746 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69228); (R-MMU-212436)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "19224205;20173027;21376232;21750661;22872234;25605945;26324925;33649389;34428180;35820727;37870275;38151567", "class_list": "", "function": "Conditional knockout of parkin in adult animals leads to progressive loss of dopamine neurons in a PARIS-dependent manner., [RefSeq, PubMed]; Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; PARIS overexpression leads to reduced mitochondrial number and structural abnormalities, [RefSeq, PubMed]; PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification., [RefSeq, PubMed]; Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPR1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U133-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YP2-1", "uniprot_id": [ { "id": "NEUL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YP2", "type": "external" } ], "mass": 80429.0, "length": 704, "protein_name": "Neurolysin, mitochondrial", "gene_name": "Nln", "organism": "Mouse", "refseq_name": "neurolysin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083723", "type": "external" } ], "gene_names_uniprotkb": "Nln", "gene_names_refseq": "4930472G13Rik; Nln", "protein_names_uniprotkb": "Neurolysin, mitochondrial; 3.4.24.16; MEP; Microsomal endopeptidase; Mitochondrial oligopeptidase M; Neurotensin endopeptidase", "protein_names_refseq": "MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin, mitochondrial precursor; neurolysin, mitochondrial; neurotensin endopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75805); (R-MMU-375276)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17620116;21750661;25147932;31219806;31486527;34428180;37507081", "class_list": "", "function": "Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Melanoma cells secrete neurolysin which may have an important role in tumor proliferation/angiogenesis in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice., [RefSeq, PubMed]; These results confirm the identity of neurolysin as a novel Ang II binding site, suggesting that neurolysin may play a significant role in opposing the pathophysiological actions of the brain RAS and influencing brain morphology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJP1;Q8R3F4", "ec_number_list": [ { "id": "3.4.24.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.16", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0042277 peptide binding;GO:0008233 peptidase activity;GO:0070012 oligopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1902809 regulation of skeletal muscle fiber differentiation;GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0030163 protein catabolic process;GO:0006111 regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91YP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQW8-1", "uniprot_id": [ { "id": "NDST4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQW8", "type": "external" } ], "mass": 100655.0, "length": 872, "protein_name": "N-heparan sulfate sulfotransferase 4", "gene_name": "Ndst4", "organism": "Mouse", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4", "refseq_ac": [ { "id": "NP_072087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072087", "type": "external" } ], "gene_names_uniprotkb": "Ndst4; Hsst4", "gene_names_refseq": "4930439H17Rik; Ndst4", "protein_names_uniprotkb": "N-heparan sulfate sulfotransferase 4; 2.8.2.8; NDST-4", "protein_names_refseq": "N-HSST 4; N-deacetylase/N-sulfotransferase 4; N-heparan sulfate sulfotransferase 4; NDST-4; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (mmu:64580); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11087757;21750661;27793051", "class_list": "glycogene", "function": "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has weak deacetylase activity but high sulfotransferase activity. Plays a crucial role in the differentiation of colonic progenitor cells (PubMed:27793051)., [UniProtKB, PubMed, PubMed]; This study revealed the involvement of Ndst4 in the development and homeostasis of colonic epithelium, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D3Z1R7", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQW8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A000-1", "uniprot_id": [ { "id": "MOONR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A000", "type": "external" } ], "mass": 108875.0, "length": 959, "protein_name": "Protein moonraker", "gene_name": "4933427D14Rik; Kiaa0753", "organism": "Mouse", "refseq_name": "protein moonraker", "refseq_ac": [ { "id": "NP_083239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083239", "type": "external" } ], "gene_names_uniprotkb": "4933427D14Rik; Kiaa0753; Mnr", "gene_names_refseq": "4933427D14Rik; Gm43951; Kiaa0753; MNR", "protein_names_uniprotkb": "Protein moonraker; MNR", "protein_names_refseq": "protein moonraker", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340); orofaciodigital syndrome (Disease Ontology:DOID:4501)", "pathway": " (mmu:74477)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26643951;32848054;39245790", "class_list": "", "function": "Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. May play a role in cilium assembly., [UniProtKB, UniProtKB]; KIAA0753 enhances osteoblast differentiation suppressed by diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80XQ5;Q9CUC0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0071539 protein localization to centrosome;GO:0007099 centriole replication;GO:0061824 cytosolic ciliogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6A000-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB30-1", "uniprot_id": [ { "id": "PHKG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB30", "type": "external" } ], "mass": 46572.0, "length": 406, "protein_name": "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform", "gene_name": "Phkg2", "organism": "Mouse", "refseq_name": "phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 1", "refseq_ac": [ { "id": "NP_081164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081164", "type": "external" } ], "gene_names_uniprotkb": "Phkg2", "gene_names_refseq": "1500017I02Rik; Phkg2", "protein_names_uniprotkb": "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; 2.7.11.19; PHK-gamma-LT; PHK-gamma-T; Phosphorylase kinase subunit gamma-2", "protein_names_refseq": "PHK-gamma-LT; PHK-gamma-T; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 1; phosphorylase kinase subunit gamma-2; serine/threonine-protein kinase PHKG2", "tax_id": 10090, "disease": "glycogen storage disease IXc (Disease Ontology:DOID:0111043); glycogen storage disease (Disease Ontology:DOID:2747); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:68961); (R-MMU-70221)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H632", "ec_number_list": [ { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0004689 phosphorylase kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DB30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQA0-1", "uniprot_id": [ { "id": "NBEL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQA0", "type": "external" } ], "mass": 301924.0, "length": 2742, "protein_name": "Neurobeachin-like protein 2", "gene_name": "Nbeal2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nbeal2; Kiaa0540", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurobeachin-like protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "gray platelet syndrome (Disease Ontology:DOID:0111044)", "pathway": " (mmu:235627); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22299025;31219806;34428180", "class_list": "", "function": "Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070889 platelet alpha granule organization;GO:0007596 blood coagulation;GO:0035855 megakaryocyte development;GO:0030220 platelet formation;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZQA0-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVD5-1", "uniprot_id": [ { "id": "MPP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVD5", "type": "external" } ], "mass": 65540.0, "length": 576, "protein_name": "MAGUK p55 subfamily member 7", "gene_name": "Mpp7", "organism": "Mouse", "refseq_name": "MAGUK p55 subfamily member 7 isoform 1", "refseq_ac": [ { "id": "NP_001074756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074756", "type": "external" } ], "gene_names_uniprotkb": "Mpp7", "gene_names_refseq": "1110068J02Rik; 2810038M04Rik; 5430426E14Rik; Gm955; Mpp7", "protein_names_uniprotkb": "MAGUK p55 subfamily member 7", "protein_names_refseq": "MAGUK p55 subfamily member 7 isoform 1; MAGUK p55 subfamily member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:75739); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "21183079;21750661;27001270;34428180", "class_list": "", "function": "Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MPP7 as a novel candidate gene for Primary open angle glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148N6;Q8BZZ8;Q9D3K2", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0031334 positive regulation of protein-containing complex assembly;GO:0070830 bicellular tight junction assembly;GO:0071896 protein localization to adherens junction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BVD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R3M4-1", "uniprot_id": [ { "id": "POLI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6R3M4", "type": "external" } ], "mass": 79653.0, "length": 717, "protein_name": "DNA polymerase iota", "gene_name": "Poli", "organism": "Mouse", "refseq_name": "DNA polymerase iota isoform 1", "refseq_ac": [ { "id": "NP_001129562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129562", "type": "external" } ], "gene_names_uniprotkb": "Poli; Rad30b", "gene_names_refseq": "Poli; Rad30b", "protein_names_uniprotkb": "DNA polymerase iota; 2.7.7.7; Rad30 homolog B", "protein_names_refseq": "DNA polymerase iota isoform 1; DNA polymerase iota; RAD30 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:26447); (R-MMU-5656121); (R-MMU-5656169)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10458907;12925679;14657033;15026325;16357261;21750661;28077247;28077248;35820727;38402183", "class_list": "", "function": "DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that either DNA polymerase iota does not participate in hypermutation, or its role is nonessential and can be readily assumed by another low-fidelity polymerase., [RefSeq, PubMed]; Error-prone DNA polymerase specifically involved in DNA repair (PubMed:15026325, PubMed:16357261). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:15026325, PubMed:16357261). Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template (By similarity). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (By similarity). May play a role in hypermutation of immunoglobulin genes (By similarity). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity., [UniProtKB, UniProtKB]; Exon 2 deletion abrogates both the DNA polymerase and dRP lyase activities of Pol iota in the presence of either Mg(2+) or Mn(2+) ions. Thus, 129-derived strains of mice express catalytically inactive alternatively spliced Pol iota variant., [RefSeq, PubMed]; Mouse DNA polymerase iota lacking exon 2 (42 amino acids) is catalytically inactive in vitro., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q641P1;Q6R3M3;Q9R1A6", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006281 DNA repair;GO:0019985 translesion synthesis;GO:0071494 cellular response to UV-C", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6R3M4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35214-1", "uniprot_id": [ { "id": "OPSX_MOUSE", "url": "https://www.uniprot.org/uniprot/O35214", "type": "external" } ], "mass": 37209.0, "length": 337, "protein_name": "Visual pigment-like receptor peropsin", "gene_name": "Rrh", "organism": "Mouse", "refseq_name": "visual pigment-like receptor peropsin isoform 2", "refseq_ac": [ { "id": "NP_033128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033128", "type": "external" } ], "gene_names_uniprotkb": "Rrh", "gene_names_refseq": "Rrh", "protein_names_uniprotkb": "Visual pigment-like receptor peropsin", "protein_names_refseq": "peropsin; visual pigment-like receptor peropsin isoform 2; visual pigment-like receptor peropsin", "tax_id": 10090, "disease": "", "pathway": " (mmu:20132); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;29109151;35820727;9275222", "class_list": "", "function": "Mice with a null mutation in the peropsin gene (Rrh) exhibited normal retinal histology, normal morphology of outer segments and RPE cells, and no evidence of photoreceptor degeneration. Biochemically, Rrh-/- mice had approximately 2-fold higher vitamin A (all-trans-retinol) in the neural retina following a photobleach., [RefSeq, PubMed]; Opsin-family protein localized to the apical microvilli of the retinal pigment epithelium (RPE), where it may participate in retinoid exchange between photoreceptors and RPE or light-dependent retinoid processing (PubMed:29109151, PubMed:9275222). Although it possesses the structural features of a GPCR, no evidence for canonical G protein activation in vivo has been reported (PubMed:29109151, PubMed:9275222)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35214-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UV70-1", "uniprot_id": [ { "id": "PDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UV70", "type": "external" } ], "mass": 61180.0, "length": 538, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "Pdp1", "organism": "Mouse", "refseq_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform c", "refseq_ac": [ { "id": "NP_001028625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028625", "type": "external" } ], "gene_names_uniprotkb": "Pdp1; Ppm2c", "gene_names_refseq": "Gm1024; PDPC 1; Pdp1; Ppm2c", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; 3.1.3.43; PDP 1; PDPC 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1", "protein_names_refseq": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform c; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; protein phosphatase 2C, magnesium dependent, catalytic subunit; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehyrogenase phosphatase catalytic subunit 1", "tax_id": 10090, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:381511); (R-MMU-204174)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19411760;21750661;27538372;31219806;34428180;38301889", "class_list": "", "function": "Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1)., [RefSeq, PubMed]; Defects in PP2Cm may be responsible for a subset of human maple syrup urine disease, [RefSeq, PubMed]; Mitochondrial PDP1 is a potential regulator that controls cardiac differentiation at an early differentiation stage in mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA;GO:0035970 peptidyl-threonine dephosphorylation;GO:0140176 positive regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UV70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52430-1", "uniprot_id": [ { "id": "PON1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52430", "type": "external" } ], "mass": 39565.0, "length": 355, "protein_name": "Serum paraoxonase/arylesterase 1", "gene_name": "Pon1", "organism": "Mouse", "refseq_name": "serum paraoxonase/arylesterase 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035264", "type": "external" } ], "gene_names_uniprotkb": "Pon1; Pon", "gene_names_refseq": "Pon1; Pon", "protein_names_uniprotkb": "Serum paraoxonase/arylesterase 1; 3.1.1.2; 3.1.1.81; 3.1.8.1; A-esterase 1; Aromatic esterase 1; PON 1; Serum aryldialkylphosphatase 1", "protein_names_refseq": "A-esterase 1; PON 1; aromatic esterase 1; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1 isoform 1 precursor; serum paraoxonase/arylesterase 1", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); cerebral cavernous malformation (Disease Ontology:DOID:0060669); bone disease (Disease Ontology:DOID:0080001); beta-thalassemia major (Disease Ontology:DOID:0080771); keratoconus (Disease Ontology:DOID:10126); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); glucose intolerance (Disease Ontology:DOID:10603); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); Behcet's disease (Disease Ontology:DOID:13241); exfoliation syndrome (Disease Ontology:DOID:13641); capillary leak syndrome (Disease Ontology:DOID:14400); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:18979); (R-MMU-2142688); (R-MMU-9754706)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15963993;17330941;21750661;26495903;26740625;28011936;30905786;32152506;32976529;33838286;34428180;35984892;36899882;37453647;37507081;39627609;40997131;7638166;8601628;9170151", "class_list": "", "function": "Ccl2 gene ablation protects LDL receptor and PON1 double deficient mice from liver injury, oxidative stress and inflammation., [RefSeq, PubMed]; Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet., [RefSeq, PubMed]; Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 48, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91X30", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.81", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0005576 extracellular region", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0046434 organophosphate catabolic process;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P52430-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0F2B4-1", "uniprot_id": [ { "id": "NLGN4_MOUSE", "url": "https://www.uniprot.org/uniprot/B0F2B4", "type": "external" } ], "mass": 97348.0, "length": 945, "protein_name": "Neuroligin 4-like", "gene_name": "Nlgn4l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nlgn4l; Nl4*; Nlgn4x; Nlgn4", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuroligin 4-like; NL-4; Neuroligin-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (R-MMU-6794361)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18227507;18434543;21282647;21750661;30100184;37828378", "class_list": "glycogene", "function": "Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in the formation or maintenance of synaptic junctions via its interactions (via the extracellular domains) with neurexin family members. Plays a role in synaptic signal transmission., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7LAI9;B1P942", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031404 chloride ion binding;GO:0097110 scaffold protein binding;GO:0042043 neurexin family protein binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0003360 brainstem development;GO:0008049 male courtship behavior;GO:0002124 territorial aggressive behavior;GO:0007416 synapse assembly;GO:0035176 social behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B0F2B4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55065-1", "uniprot_id": [ { "id": "PLTP_MOUSE", "url": "https://www.uniprot.org/uniprot/P55065", "type": "external" } ], "mass": 54453.0, "length": 493, "protein_name": "Phospholipid transfer protein", "gene_name": "Pltp", "organism": "Mouse", "refseq_name": "phospholipid transfer protein isoform a precursor", "refseq_ac": [ { "id": "NP_035255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035255", "type": "external" } ], "gene_names_uniprotkb": "Pltp", "gene_names_refseq": "Bpife; OD107; Pltp", "protein_names_uniprotkb": "Phospholipid transfer protein; Lipid transfer protein II", "protein_names_refseq": "lipid transfer protein II; phospholipid transfer protein isoform a precursor", "tax_id": 10090, "disease": "dry eye syndrome (Disease Ontology:DOID:10140); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:18830); (R-MMU-8964058)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10079112;16944957;21750661;23386199;35820727;35982498;36362012;36852467;37620514;7615508;7654777", "class_list": "", "function": "C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia. Publication Status: Online-Only, [RefSeq, PubMed]; Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models. Publication Status: Online-Only, [RefSeq, PubMed]; Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:10079112, PubMed:7615508, PubMed:7654777). Facilitates the transfer of a spectrum of different lipid molecules, including sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, and phosphatidyl ethanolamine (PubMed:10079112). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (By similarity). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (By similarity). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q99L70", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity;GO:0008035 high-density lipoprotein particle binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:1901611 phosphatidylglycerol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0046836 glycolipid transport;GO:0006869 lipid transport;GO:0010875 positive regulation of cholesterol efflux;GO:0035627 ceramide transport;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P55065-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URQ7-1", "uniprot_id": [ { "id": "MTHSD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URQ7", "type": "external" } ], "mass": 40789.0, "length": 372, "protein_name": "Methenyltetrahydrofolate synthase domain-containing protein", "gene_name": "Mthfsd", "organism": "Mouse", "refseq_name": "methenyltetrahydrofolate synthase domain-containing protein isoform 1", "refseq_ac": [ { "id": "NP_001159954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159954", "type": "external" } ], "gene_names_uniprotkb": "Mthfsd", "gene_names_refseq": "C920004D05; Mthfsd", "protein_names_uniprotkb": "Methenyltetrahydrofolate synthase domain-containing protein", "protein_names_refseq": "methenyltetrahydrofolate synthase domain-containing protein isoform 1; methenyltetrahydrofolate synthase domain-containing protein; methenyltetrahydrofolate synthetase domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:234814)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;26525917;31219806", "class_list": "", "function": "Identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WS4;Q8BUM0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIN1-1", "uniprot_id": [ { "id": "PEBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIN1", "type": "external" } ], "mass": 21191.0, "length": 187, "protein_name": "Phosphatidylethanolamine-binding protein 2", "gene_name": "Pbp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pbp2; Pebp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylethanolamine-binding protein 2; PEBP-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:76400)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12037323;12193403;21750661;31219806", "class_list": "", "function": "May bind to phospholipids. May act as serine protease inhibitor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KND5;Q8VIN0;Q9DA20", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007286 spermatid development;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VIN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57787-1", "uniprot_id": [ { "id": "MOT4_MOUSE", "url": "https://www.uniprot.org/uniprot/P57787", "type": "external" } ], "mass": 50373.0, "length": 470, "protein_name": "Monocarboxylate transporter 4", "gene_name": "Slc16a3", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 4", "refseq_ac": [ { "id": "NP_001033742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033742", "type": "external" } ], "gene_names_uniprotkb": "Slc16a3; Mct4", "gene_names_refseq": "Mct3; Mct4; Slc16a3", "protein_names_uniprotkb": "Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3", "protein_names_refseq": "MCT 4; monocarboxylate transporter 4; solute carrier family 16 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:80879); (R-MMU-210991); (R-MMU-433692)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18385447;19144319;20022372;21750661;25428506;26495903;27802388;31219806;31837519;34428180", "class_list": "", "function": "In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4 in cell membrane is opposite polarity found in human., [RefSeq, PubMed]; Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (Probable)., [UniProtKB, UniProtKB, PubMed]; Unique roles for slc16a3 in monocarboxylate transport and pH regulation during preimplantation development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ES80;Q9ESF8", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0015650 lactate:proton symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:1901475 pyruvate transmembrane transport;GO:0035879 plasma membrane lactate transport;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P57787-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q4-1", "uniprot_id": [ { "id": "MO4L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q4", "type": "external" } ], "mass": 32184.0, "length": 288, "protein_name": "Mortality factor 4-like protein 2", "gene_name": "Morf4l2", "organism": "Mouse", "refseq_name": "mortality factor 4-like protein 2", "refseq_ac": [ { "id": "NP_001161697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161697", "type": "external" } ], "gene_names_uniprotkb": "Morf4l2; Kiaa0026; Sid393", "gene_names_refseq": "2410017O14Rik; Morf4l2; Mrgx; Sid393p; mKIAA0026", "protein_names_uniprotkb": "Mortality factor 4-like protein 2; MORF-related gene X protein; Sid 393; Transcription factor-like protein MRGX", "protein_names_refseq": "MORF-related gene X protein; mortality factor 4-like protein 2; sid 393; transcription factor-like protein Mrgx", "tax_id": 10090, "disease": "", "pathway": " (mmu:56397)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15923606;21750661;30779550", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that MRGX is ubiquitously expressed in all tissues of adult mice and also during embryogenesis, and overlaps with its homolog Mrg15., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEB2;Q3UL62;Q6DIB1;Q6ZQK7;Q8C201;Q8C6C2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R0Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AS42-1", "uniprot_id": [ { "id": "NB5R5_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AS42", "type": "external" } ], "mass": 35884.0, "length": 316, "protein_name": "NADH-cytochrome b5 reductase-like", "gene_name": "Cyb5rl", "organism": "Mouse", "refseq_name": "NADH-cytochrome b5 reductase-like isoform 1", "refseq_ac": [ { "id": "NP_001333481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333481", "type": "external" } ], "gene_names_uniprotkb": "Cyb5rl", "gene_names_refseq": "2810410C14Rik; Cyb5rl", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase-like; 1.6.2.2", "protein_names_refseq": "NADH-cytochrome b5 reductase-like isoform 1; NADH-cytochrome b5 reductase-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:230582); (R-MMU-1237044)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction., [UniProtKB, UniProtKB]; Putative NADH-cytochrome b5 reductases family protein. May participate in fatty acid desaturation and elongation, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AS41;Q571N5;Q80W48;Q99KB7", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AS42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35317-1", "uniprot_id": [ { "id": "PBX3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35317", "type": "external" } ], "mass": 47204.0, "length": 434, "protein_name": "Pre-B-cell leukemia transcription factor 3", "gene_name": "Pbx3", "organism": "Mouse", "refseq_name": "pre-B-cell leukemia transcription factor 3 isoform PBX3b", "refseq_ac": [ { "id": "NP_001277505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277505", "type": "external" } ], "gene_names_uniprotkb": "Pbx3", "gene_names_refseq": "Pbx3", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 3; Homeobox protein PBX3", "protein_names_refseq": "homeobox protein PBX3; pre-B-cell leukemia transcription factor 3 isoform PBX3b; pre-B-cell leukemia transcription factor 3", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:18516)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38528641", "class_list": "", "function": "Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925W2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0006351 DNA-templated transcription;GO:0008344 adult locomotory behavior;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002087 regulation of respiratory gaseous exchange by nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35317-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDM1-1", "uniprot_id": [ { "id": "MSL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDM1", "type": "external" } ], "mass": 67320.0, "length": 616, "protein_name": "Male-specific lethal 1 homolog", "gene_name": "Msl1", "organism": "Mouse", "refseq_name": "male-specific lethal 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_082998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082998", "type": "external" } ], "gene_names_uniprotkb": "Msl1; Msl1l1", "gene_names_refseq": "2810017F12Rik; 4121402D02Rik; 4930463F05Rik; Msl-1; Msl1", "protein_names_uniprotkb": "Male-specific lethal 1 homolog; Hampin; MSL-1; MSL1-like 1; Male-specific lethal 1-like 1", "protein_names_refseq": "MSL1-like 1; hampin; male-specific lethal 1 homolog isoform 1; male-specific lethal 1 homolog; male-specific lethal 1-like 1; male-specific lethal-1 homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74026); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16119455;17335777;19390865;21183079;21217699;21750661;23523075;24842875;24913909;27183194;28609438;34418053;37279389", "class_list": "", "function": "Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). Publication Status: Online-Only, [RefSeq, PubMed]; Describes the primary structure of the protein hampin, which shares about 26% sequence identity with the Drosophila MSL1 protein. In mouse, at least five splice isoforms exist, two of which have restricted tissue specificity (testes)., [RefSeq, PubMed]; Hampin may be linked to diverse regulatory processes in the nucleus, [RefSeq, PubMed]; MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation., [RefSeq, PubMed]; Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:21217699, PubMed:23523075, PubMed:24842875, PubMed:24913909). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (PubMed:23523075). X up-regulation is required to compensate for autosomal biallelic expression (PubMed:23523075). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KFP2;A3KFP4;Q27QB3;Q3TTE5;Q80XS0;Q8BPN3;Q9CXF9;Q9D5C9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0072487 MSL complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6PDM1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MT2-1", "uniprot_id": [ { "id": "MSH4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MT2", "type": "external" } ], "mass": 107006.0, "length": 958, "protein_name": "MutS protein homolog 4", "gene_name": "Msh4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Msh4", "gene_names_refseq": "", "protein_names_uniprotkb": "MutS protein homolog 4; mMsh4", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 2 (Disease Ontology:DOID:0070164); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:55993)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11178747;11553915;21750661;30272023;30746471;31219806;31599954;35820727", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR)., [UniProtKB, UniProtKB]; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920J1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006298 mismatch repair;GO:0001541 ovarian follicle development;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99MT2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13705-1", "uniprot_id": [ { "id": "MSH3_MOUSE", "url": "https://www.uniprot.org/uniprot/P13705", "type": "external" } ], "mass": 123074.0, "length": 1091, "protein_name": "DNA mismatch repair protein Msh3", "gene_name": "Msh3", "organism": "Mouse", "refseq_name": "DNA mismatch repair protein Msh3 isoform 1", "refseq_ac": [ { "id": "NP_034959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034959", "type": "external" } ], "gene_names_uniprotkb": "Msh3; Rep-3", "gene_names_refseq": "D13Em1; Msh3; REP-1; Rep-3; Rep3", "protein_names_uniprotkb": "DNA mismatch repair protein Msh3; Protein repair-1; Protein repair-3; REP-1; REP-3", "protein_names_refseq": "DNA mismatch repair protein Msh3 isoform 1; DNA mismatch repair protein Msh3; protein repair-1; protein repair-3", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); familial adenomatous polyposis 4 (Disease Ontology:DOID:0080412); endometrial cancer (Disease Ontology:DOID:1380); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:17686); (R-MMU-5358606)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2674679;30059200;34428180;38267530;7926796", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0003684 damaged DNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032302 MutSbeta complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:0006281 DNA repair;GO:0006298 mismatch repair;GO:0045910 negative regulation of DNA recombination;GO:0043570 maintenance of DNA repeat elements", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13705-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TEW6-1", "uniprot_id": [ { "id": "MPZL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TEW6", "type": "external" } ], "mass": 29495.0, "length": 270, "protein_name": "Myelin protein zero-like protein 1", "gene_name": "Mpzl1", "organism": "Mouse", "refseq_name": "myelin protein zero-like protein 1 isoform b precursor", "refseq_ac": [ { "id": "NP_001001880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001880", "type": "external" } ], "gene_names_uniprotkb": "Mpzl1; Pzr", "gene_names_refseq": "1110007A10Rik; Mpzl1; PZR", "protein_names_uniprotkb": "Myelin protein zero-like protein 1; Protein zero-related", "protein_names_refseq": "myelin protein zero-like protein 1 isoform b precursor; myelin protein zero-like protein 1; protein zero-related", "tax_id": 10090, "disease": "", "pathway": " (mmu:68481)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17440960;18378677;18568953;19349973;21750661;25428506;30084848;30899004;32584792;37279992", "class_list": "", "function": "Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity)., [UniProtKB]; Describe the function of the mPZR isoforms in vivo, particularly with respect to their roles in regulating SHP-2-dependent cell migration during development., [RefSeq, PubMed]; PZR promotes tumorigenicity of lung cancer cells by regulating cell migration and invasion via modulating oxidative stress and cell adhesion., [RefSeq, PubMed]; Phosphorylation and localization of PZR in cultufred endothelial cells is reported., [RefSeq, PubMed]; SIRPalpha and PZR serve as scaffolds that facilitate plasma membrane recruitment and signaling of NS-associated SHP-2 mutants., [RefSeq, PubMed]; Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2VW02;Q6GQX5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3TEW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9M4-1", "uniprot_id": [ { "id": "PDZD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9M4", "type": "external" } ], "mass": 29761.0, "length": 266, "protein_name": "PDZ domain-containing protein 9", "gene_name": "Pdzd9", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein 9 isoform 1", "refseq_ac": [ { "id": "NP_001035226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035226", "type": "external" } ], "gene_names_uniprotkb": "Pdzd9", "gene_names_refseq": "4930408O21Rik; Pdzd9", "protein_names_uniprotkb": "PDZ domain-containing protein 9", "protein_names_refseq": "PDZ domain-containing protein 9 isoform 1; PDZ domain-containing protein 9; PDZ domain-containing protein C16orf65 homolog", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR71", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9M4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRA4-1", "uniprot_id": [ { "id": "MSMO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRA4", "type": "external" } ], "mass": 34772.0, "length": 293, "protein_name": "Methylsterol monooxygenase 1", "gene_name": "Msmo1", "organism": "Mouse", "refseq_name": "methylsterol monooxygenase 1", "refseq_ac": [ { "id": "NP_079712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079712", "type": "external" } ], "gene_names_uniprotkb": "Msmo1; Sc4mol", "gene_names_refseq": "1500001G16Rik; DESP4; ERG25; Msmo1; Sc4mol", "protein_names_uniprotkb": "Methylsterol monooxygenase 1; 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase", "protein_names_refseq": "C-4 methylsterol oxidase; methylsterol monooxygenase 1; sterol-C4-methyl oxidase-like", "tax_id": 10090, "disease": "chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (mmu:66234); (R-MMU-6807047)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;23125191;34428180;37828378", "class_list": "", "function": "Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol., [UniProtKB, UniProtKB]; This work identifies a critical role for SC4MOL and NSDHL in the regulation of EGFR signaling and endocytic trafficking and suggests novel strategies to increase the potency of EGFR antagonists in tumors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543V8", "ec_number_list": [ { "id": "1.14.18.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.9", "type": "external" } ], "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol;GO:0036197 zymosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CRA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU20-1", "uniprot_id": [ { "id": "MTHR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU20", "type": "external" } ], "mass": 74580.0, "length": 654, "protein_name": "Methylenetetrahydrofolate reductase (NADPH)", "gene_name": "Mthfr", "organism": "Mouse", "refseq_name": "methylenetetrahydrofolate reductase (NADPH) isoform b", "refseq_ac": [ { "id": "NP_034970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034970", "type": "external" } ], "gene_names_uniprotkb": "Mthfr", "gene_names_refseq": "Mthfr", "protein_names_uniprotkb": "Methylenetetrahydrofolate reductase (NADPH); 1.5.1.53", "protein_names_refseq": "5,10-methylenetetrahydrofolate reductase; methylenetetrahydrofolate reductase (NADPH) isoform b; methylenetetrahydrofolate reductase (NADPH)", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral artery disease (Disease Ontology:DOID:0050830); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); myeloid neoplasm (Disease Ontology:DOID:0070004); spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); graft-versus-host disease (Disease Ontology:DOID:0081267); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); migraine with aura (Disease Ontology:DOID:10024); open-angle glaucoma (Disease Ontology:DOID:1067); kidney failure (Disease Ontology:DOID:1074); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrosclerosis (Disease Ontology:DOID:11664); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); male infertility (Disease Ontology:DOID:12336); Graves' disease (Disease Ontology:DOID:12361); cardiovascular system disease (Disease Ontology:DOID:1287); carotid stenosis (Disease Ontology:DOID:13001); angle-closure glaucoma (Disease Ontology:DOID:13550); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459); thrombocytopenia (Disease Ontology:DOID:1588); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); rectal benign neoplasm (Disease Ontology:DOID:1984); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); anemia (Disease Ontology:DOID:2355); renal artery disease (Disease Ontology:DOID:2388); thrombophilia (Disease Ontology:DOID:2452); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); lipid metabolism disorder (Disease Ontology:DOID:3146); ischemia (Disease Ontology:DOID:326); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); mitral valve disease (Disease Ontology:DOID:61); migraine (Disease Ontology:DOID:6364); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); smallpox (Disease Ontology:DOID:8736); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); hyperhomocysteinemia (Disease Ontology:DOID:9279); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypopituitarism (Disease Ontology:DOID:9406); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:17769); (R-MMU-196757)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;21952136;22872234;34203471;34428180;35820727;38327171;9680386", "class_list": "", "function": "Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Folate Deficiency and/or the Genetic Variant Mthfr[677C >T] Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 90, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDE4", "ec_number_list": [ { "id": "1.5.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.53", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0044877 protein-containing complex binding;GO:0004489 methylenetetrahydrofolate reductase [NAD(P)H] activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001843 neural tube closure;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0006555 methionine metabolic process;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WU20-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62334-1", "uniprot_id": [ { "id": "PRS10_MOUSE", "url": "https://www.uniprot.org/uniprot/P62334", "type": "external" } ], "mass": 44173.0, "length": 389, "protein_name": "26S proteasome regulatory subunit 10B", "gene_name": "Psmc6", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 10B isoform 1", "refseq_ac": [ { "id": "NP_080235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080235", "type": "external" } ], "gene_names_uniprotkb": "Psmc6; Sug2", "gene_names_refseq": "2300001E01Rik; Psmc6", "protein_names_uniprotkb": "26S proteasome regulatory subunit 10B; 26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42", "protein_names_refseq": "26S protease regulatory subunit 10B; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; 26S proteasome regulatory subunit 10B isoform 1; 26S proteasome regulatory subunit 10B; proteasome 26S subunit ATPase 6; proteasome subunit p42", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696)", "pathway": " (mmu:67089); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 56, "publication_count": 7, "publication_id_list": "16857966;21750661;23806337;32017075;34428180;36599955;39627609", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]; PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjogren's syndrome., [RefSeq, PubMed]; PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P49719;Q3TKK1;Q810A6;Q92524;Q9CXH9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0090261 positive regulation of inclusion body assembly;GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15331-1", "uniprot_id": [ { "id": "PERI_MOUSE", "url": "https://www.uniprot.org/uniprot/P15331", "type": "external" } ], "mass": 54268.0, "length": 475, "protein_name": "Peripherin", "gene_name": "Prph", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prph; Prph1", "gene_names_refseq": "", "protein_names_uniprotkb": "Peripherin", "protein_names_refseq": "", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193)", "pathway": " (mmu:19132)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10426285;12065660;1294287;15322088;17569669;17899157;18709437;20132868;21750661;22723690;23179371;2767051;30084848;31219806;34428180;34887587;9971739", "class_list": "", "function": "Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form filamentous networks (PubMed:10426285, PubMed:15322088, PubMed:22723690). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (PubMed:23179371). Plays a role in the development of unmyelinated sensory neurons (PubMed:12065660). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (PubMed:20132868)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35688;O35689", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0044877 protein-containing complex binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043204 perikaryon", "go_biological_process": "GO:0045109 intermediate filament organization;GO:0045104 intermediate filament cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P15331-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23492-1", "uniprot_id": [ { "id": "PNPH_MOUSE", "url": "https://www.uniprot.org/uniprot/P23492", "type": "external" } ], "mass": 32277.0, "length": 289, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "Pnp", "organism": "Mouse", "refseq_name": "purine nucleoside phosphorylase isoform 1", "refseq_ac": [ { "id": "NP_038660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038660", "type": "external" } ], "gene_names_uniprotkb": "Pnp; Np; Pnp1", "gene_names_refseq": "Np-1; Np-2; Np; Pnp1; Pnp", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP", "protein_names_refseq": "inosine phosphorylase; inosine-guanosine phosphorylase; purine nucleoside phosphorylase isoform 1; purine-nucleoside phosphorylase 1", "tax_id": 10090, "disease": "purine nucleoside phosphorylase deficiency (Disease Ontology:DOID:5813); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (mmu:18950); (R-MMU-6798695); (R-MMU-74217); (R-MMU-74259); (R-MMU-9755088)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10859343;1374046;1902950;19224205;20173027;21750661;22521465;25428506;30024931;30084848;31219806;34428180;6407470;7903568", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine., [UniProtKB, PubMed, PubMed, PubMed]; Loss of PNP expression is associated with hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; PNP deficiency causes cerebellar abnormalities, including Purkinje cell damage and progressive motor deficits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJT6", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "4.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0042802 identical protein binding;GO:0001882 nucleoside binding;GO:0002060 purine nucleobase binding;GO:0004731 purine-nucleoside phosphorylase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046070 dGTP metabolic process;GO:0006154 adenosine catabolic process;GO:0006955 immune response;GO:0010332 response to gamma radiation;GO:0043101 purine-containing compound salvage", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P23492-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQZ5-1", "uniprot_id": [ { "id": "NDUA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQZ5", "type": "external" } ], "mass": 15283.0, "length": 131, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6", "gene_name": "Ndufa6", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6", "refseq_ac": [ { "id": "NP_080263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080263", "type": "external" } ], "gene_names_uniprotkb": "Ndufa6", "gene_names_refseq": "14kDa; 2700038D15Rik; B230217P19Rik; Ndufa6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; CI-B14; Complex I-B14; NADH-ubiquinone oxidoreductase B14 subunit", "protein_names_refseq": "CI-B14; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; NADH-ubiquinone oxidoreductase B14 subunit; complex I-B14", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 33 (Disease Ontology:DOID:0112097); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:67130); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;25605945;34428180;36288343;37453647;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61965-1", "uniprot_id": [ { "id": "WDR5_MOUSE", "url": "https://www.uniprot.org/uniprot/P61965", "type": "external" } ], "mass": 36588.0, "length": 334, "protein_name": "WD repeat-containing protein 5", "gene_name": "Wdr5", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 5", "refseq_ac": [ { "id": "NP_543124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543124", "type": "external" } ], "gene_names_uniprotkb": "Wdr5; Big3; Big", "gene_names_refseq": "2410008O07Rik; Big-3; Big; Wdr5", "protein_names_uniprotkb": "WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3", "protein_names_refseq": "BMP2-induced 3-kb gene protein; WD repeat-containing protein 5; WD repeat-containing protein BIG-3", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:140858); (R-MMU-201722); (R-MMU-3214841); (R-MMU-3214847); (R-MMU-3214858); (R-MMU-8936459); (R-MMU-8951664); (R-MMU-9772755); (R-MMU-9818564); (R-MMU-9943962)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "11551928;14657013;15860628;16730692;18299400;20484733;21335234;21750661;21952136;22862948;23178126;25428506;30084848;30779550;34715053;35820727;36402263", "class_list": "", "function": "BIG-3 accelerates chondrocyte differentiation in vitro, and is expressed in the growth plate during embryonic development, so is is likely to play an in vivo regulatory role in the developing growth plate., [RefSeq, PubMed]; Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity)., [UniProtKB, UniProtKB, PubMed]; Identified two proteins, NONO and WDR5, that can associate with the mammalian PER1 protein; WDR5 augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene, [RefSeq, PubMed]; Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets., [RefSeq, PubMed]; P53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells., [RefSeq, PubMed]; Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91VA5;Q922C9;Q9NWX7;Q9UGP9", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140004 histone H3Q5ser reader activity;GO:0140109 histone H3K4me1 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097228 sperm principal piece;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031175 neuron projection development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P61965-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY1-1", "uniprot_id": [ { "id": "PDCD7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTY1", "type": "external" } ], "mass": 54357.0, "length": 482, "protein_name": "Programmed cell death protein 7", "gene_name": "Pdcd7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdcd7", "gene_names_refseq": "", "protein_names_uniprotkb": "Programmed cell death protein 7; ES18", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-72165)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10037816;10087507;21750661;31219806", "class_list": "", "function": "Promotes apoptosis when overexpressed., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5D9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex;GO:0089701 U2AF complex;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:0006915 apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0051384 response to glucocorticoid;GO:0008380 RNA splicing;GO:0070234 positive regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63015-1", "uniprot_id": [ { "id": "PAX6_MOUSE", "url": "https://www.uniprot.org/uniprot/P63015", "type": "external" } ], "mass": 46683.0, "length": 422, "protein_name": "Paired box protein Pax-6", "gene_name": "Pax6", "organism": "Mouse", "refseq_name": "paired box protein Pax-6 isoform 1", "refseq_ac": [ { "id": "NP_001231127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231127", "type": "external" } ], "gene_names_uniprotkb": "Pax6; Pax-6; Sey", "gene_names_refseq": "1500038E17Rik; AEY11; Dey; Gsfaey11; Pax-6; Pax6; Sey", "protein_names_uniprotkb": "Paired box protein Pax-6; Oculorhombin", "protein_names_refseq": "Dickie's small eye; oculorhombin; paired box gene 6; paired box protein Pax-6 isoform 1; paired box protein Pax-6", "tax_id": 10090, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); WAGR syndrome (Disease Ontology:DOID:14515); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (mmu:18508)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11779807;1612585;16464444;1684639;1685142;1687460;17901057;18628401;21084637;21750661;23990468;34678516;9163426", "class_list": "", "function": "Pax6 expression, analyzed using a BAC transgene, revealed the presence of a paired-less isoform in the eye and olfactory bulb., [RefSeq, PubMed]; This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]., [RefSeq]; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P32117;P70601;Q3UTV5;Q62222;Q64037;Q8CEI5;Q8VDB5;Q921Q8", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0061034 olfactory bulb mitral cell layer development;GO:0003322 pancreatic A cell development;GO:0009786 regulation of asymmetric cell division;GO:0021905 forebrain-midbrain boundary formation;GO:0048708 astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P63015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924A0-1", "uniprot_id": [ { "id": "TF7L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924A0", "type": "external" } ], "mass": 51217.0, "length": 459, "protein_name": "Transcription factor 7-like 2", "gene_name": "Tcf7l2", "organism": "Mouse", "refseq_name": "transcription factor 7-like 2 isoform 1", "refseq_ac": [ { "id": "NP_001136390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136390", "type": "external" } ], "gene_names_uniprotkb": "Tcf7l2; Tcf4", "gene_names_refseq": "TCF4B; TCF4E; Tcf-4; Tcf4; Tcf7l2", "protein_names_uniprotkb": "Transcription factor 7-like 2; HMG box transcription factor 4; T-cell factor 4; T-cell-specific transcription factor 4; TCF-4; mTCF-4", "protein_names_refseq": "HMG box transcription factor 4; HMG box transcription factor TCF7L2; T-cell-specific transcription factor 4; transcription factor 7-like 2 isoform 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); gestational diabetes (Disease Ontology:DOID:11714); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21416); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4086398); (R-MMU-4641265); (R-MMU-8951430); (R-MMU-9825892)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "11845287;16291758;19816403;21750661;21856776;9488439;9697701;9880534", "class_list": "", "function": "Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70574;Q8C834;Q91XP2;Q91XP3;Q91XP4;Q924A1;Q9Z0V3;Q9Z0V4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0048619 embryonic hindgut morphogenesis;GO:1901142 insulin metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q924A0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIP3-1", "uniprot_id": [ { "id": "I17RB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIP3", "type": "external" } ], "mass": 55617.0, "length": 499, "protein_name": "Interleukin-17 receptor B", "gene_name": "Il17rb", "organism": "Mouse", "refseq_name": "interleukin-17 receptor B precursor", "refseq_ac": [ { "id": "NP_062529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062529", "type": "external" } ], "gene_names_uniprotkb": "Il17rb; Evi27; Il17br", "gene_names_refseq": "Evi27; IL-17ER; IL-17Rh1; IL17RH1; Il17br; Il17rb", "protein_names_uniprotkb": "Interleukin-17 receptor B; IL-17 receptor B; IL-17 receptor homolog 1; IL-17B receptor; IL-17ER; IL-17RB; IL-17Rh1; IL17Rh1; Interleukin-17B receptor", "protein_names_refseq": "IL-17 receptor B; IL-17 receptor homolog 1; IL-17B receptor; IL-17RB; ecotropic viral integration site 27; interleukin 17B receptor; interleukin-17 receptor B precursor", "tax_id": 10090, "disease": "interstitial lung disease (Disease Ontology:DOID:3082)", "pathway": " (mmu:50905)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10815801;16393988;18768888;21750661", "class_list": "", "function": "IL-25-mediated activities require both IL-17RB and IL-17RA in this example of an IL-17 family ligand that utilizes a heteromeric receptor complex., [RefSeq, PubMed]; Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells., [UniProtKB, UniProtKB, UniProtKB]; TRAF6 plays a critical role in IL-25R-mediated NF-kappaB activation and gene expression., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIP2", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIP3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WJ6-1", "uniprot_id": [ { "id": "MRP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WJ6", "type": "external" } ], "mass": 153060.0, "length": 1366, "protein_name": "ATP-binding cassette sub-family C member 12", "gene_name": "Abcc12", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 12", "refseq_ac": [ { "id": "NP_766500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766500", "type": "external" } ], "gene_names_uniprotkb": "Abcc12; Mrp9", "gene_names_refseq": "4930467B22Rik; Abcc12; MRP9", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 12; Multidrug resistance-associated protein 9", "protein_names_refseq": "ATP-binding cassette sub-family C member 12; ATP-binding cassette transporter sub-family C member 12; ATP-binding cassette, sub-family C (CFTR/MRP), member 12; multidrug resistance-associated protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:244562)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12801629;17472575;21750661;31219806;33771553;35121660", "class_list": "", "function": "Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms., [RefSeq, PubMed]; Full-length Mrp9 was detected only in testicular germ cells and mouse sperm. In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria., [RefSeq, PubMed]; MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function., [RefSeq, PubMed]; Probable transporter, its substrate specificity is unknown., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RRF4;Q80WJ2;Q80WJ3;Q8C0P3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80WJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R182-1", "uniprot_id": [ { "id": "TMG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R182", "type": "external" } ], "mass": 22369.0, "length": 198, "protein_name": "Transmembrane gamma-carboxyglutamic acid protein 2", "gene_name": "Prrg2", "organism": "Mouse", "refseq_name": "transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_075375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075375", "type": "external" } ], "gene_names_uniprotkb": "Prrg2; N4wbp1", "gene_names_refseq": "1600014G02Rik; 2510041M06Rik; N4WBP1; Prrg2", "protein_names_uniprotkb": "Transmembrane gamma-carboxyglutamic acid protein 2; NEDD4 WW domain-binding protein 1; Proline-rich Gla protein 2; Proline-rich gamma-carboxyglutamic acid protein 2", "protein_names_refseq": "NEDD4 WW domain-binding protein 1; proline-rich Gla protein 2; proline-rich gamma-carboxyglutamic acid protein 2; transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor; transmembrane gamma-carboxyglutamic acid protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:65116)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11042109;21750661", "class_list": "", "function": "Vitamin K-dependent protein that is essential for calcium homeostasis and haemostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQI2", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R182-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZG2-1", "uniprot_id": [ { "id": "MPPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZG2", "type": "external" } ], "mass": 37214.0, "length": 326, "protein_name": "Metallophosphoesterase domain-containing protein 1", "gene_name": "Mpped1", "organism": "Mouse", "refseq_name": "metallophosphoesterase domain-containing protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766198", "type": "external" } ], "gene_names_uniprotkb": "Mpped1; D15Bwg0669e", "gene_names_refseq": "6230403M19; D15Bwg0669e; Mpped1", "protein_names_uniprotkb": "Metallophosphoesterase domain-containing protein 1; 3.1.-.-", "protein_names_refseq": "metallophosphoesterase domain-containing protein 1 isoform 1 precursor; metallophosphoesterase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223726)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May have metallophosphoesterase activity (in vitro)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PW09;Q3TMS4;Q3TYC7", "ec_number_list": [], "go_molecular_function": "GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6J5-1", "uniprot_id": [ { "id": "NDUB8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6J5", "type": "external" } ], "mass": 21876.0, "length": 186, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "gene_name": "Ndufb8", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_080337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080337", "type": "external" } ], "gene_names_uniprotkb": "Ndufb8", "gene_names_refseq": "2900010I05Rik; CI-ASHI; Ndufb8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; CI-ASHI; Complex I-ASHI; NADH-ubiquinone oxidoreductase ASHI subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH-ubiquinone oxidoreductase ASHI subunit; complex I-ASHI", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 32 (Disease Ontology:DOID:0112080); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (mmu:67264); (R-MMU-1268020); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "21750661;24217272;31219806;34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Study reports mitochondrial dysfunction in TgCRND8 mouse model of Alzheimer's disease and identifies the NDUFB8 subunit of complex I as a key target of A-beta toxicity, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6M7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D6J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H6T1-1", "uniprot_id": [ { "id": "PRS40_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H6T1", "type": "external" } ], "mass": 40146.0, "length": 365, "protein_name": "Serine protease 40", "gene_name": "Prss40", "organism": "Mouse", "refseq_name": "serine protease 40 precursor", "refseq_ac": [ { "id": "NP_033382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033382", "type": "external" } ], "gene_names_uniprotkb": "Prss40; Tesp2", "gene_names_refseq": "Prss40; Tesp2", "protein_names_uniprotkb": "Serine protease 40; 3.4.21.-; Testicular serine protease 2", "protein_names_refseq": "protease, serine 40; serine protease 40 precursor; testicular serine protease 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:21756)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9588171", "class_list": "", "function": "May play an important role in the sperm/egg interaction; released during the acrosome reaction., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QL09;O70170", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6H6T1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUX5-1", "uniprot_id": [ { "id": "IRAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUX5", "type": "external" } ], "mass": 97434.0, "length": 899, "protein_name": "Inositol 1,4,5-triphosphate receptor associated 1", "gene_name": "Irag1", "organism": "Mouse", "refseq_name": "inositol 1,4,5-triphosphate receptor associated 1", "refseq_ac": [ { "id": "NP_919446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919446", "type": "external" } ], "gene_names_uniprotkb": "Irag1; Irag; Mrvi1", "gene_names_refseq": "Irag1; Irag; Mrvi1; Ris1", "protein_names_uniprotkb": "Inositol 1,4,5-triphosphate receptor associated 1; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; JAW1-related protein MRVI1; Murine retrovirus integration site 1 protein; Protein MRVI1", "protein_names_refseq": "JAW1-related protein MRVI1; MRV integration site 1; inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; murine retrovirus integration site 1 protein; protein MRVI1; retroviral integration site 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17540); (R-MMU-418457)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10321731;15388327;15483626;16990611;21183079;21750661;25428506;30084848;32647060;33066124;34418053;34428180;36210013", "class_list": "", "function": "Conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI, [RefSeq, PubMed]; IRAG1 Deficient Mice Develop PKG1beta Dependent Pulmonary Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (PubMed:32647060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reports use of non-AUG (CUG) translation initiation codon in one of the transcript variants of MRVI1 gene in mouse and human., [RefSeq, PubMed]; This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U069;Q9R2C5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016529 sarcoplasmic reticulum;GO:0005737 cytoplasm", "go_biological_process": "GO:0060087 relaxation of vascular associated smooth muscle;GO:0045986 negative regulation of smooth muscle contraction;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WUX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HWB0-1", "uniprot_id": [ { "id": "HMR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8HWB0", "type": "external" } ], "mass": 39391.0, "length": 341, "protein_name": "Major histocompatibility complex class I-related protein 1", "gene_name": "Mr1", "organism": "Mouse", "refseq_name": "major histocompatibility complex class I-related protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032235", "type": "external" } ], "gene_names_uniprotkb": "Mr1; Mr1a", "gene_names_refseq": "H2ls; Mr1", "protein_names_uniprotkb": "Major histocompatibility complex class I-related protein 1; Class I histocompatibility antigen-like protein; MHC class I-related protein 1", "protein_names_refseq": "MCH class I; MHC class I-related gene protein; MHC class I-related protein 1; class I histocompatibility antigen-like protein; histocompatibility-2 complex class 1-like sequence; major histocompatibility complex class I-related gene protein; major histocompatibility complex class I-related protein 1 isoform 1 precursor; major histocompatibility complex class I-related protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15064)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11785959;12634786;12794138;15802267;20581831;21750661;24101382;25605945;31113973;34428180;35820727;38537698;9325151;9780177", "class_list": "", "function": "Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:15802267, PubMed:20581831, PubMed:24101382, PubMed:38537698). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (PubMed:12634786, PubMed:31113973). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity). May present tumor-enriched pyridoxal and pyridoxal 5'-phosphate antigens, enabling preferential recognition of cancer cells (By similarity). Presents nucleobase carbonyl adducts generated during oxidative stress. Captures M3Ade, a nucleobase adduct composed of one adenine modified by a malondialdehyde trimer, for recognition by MR1-restricted T cell clones expressing a polyclonal TCR repertoire (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; MR1 protein can associate with beta(2)-microglobulin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O19478", "ec_number_list": [], "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8HWB0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUA3-1", "uniprot_id": [ { "id": "PFKAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUA3", "type": "external" } ], "mass": 85455.0, "length": 784, "protein_name": "ATP-dependent 6-phosphofructokinase, platelet type", "gene_name": "Pfkp", "organism": "Mouse", "refseq_name": "ATP-dependent 6-phosphofructokinase, platelet type isoform 2", "refseq_ac": [ { "id": "NP_001278000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278000", "type": "external" } ], "gene_names_uniprotkb": "Pfkp; Pfkc", "gene_names_refseq": "1200015H23Rik; 9330125N24Rik; ATP-PFK; PFK-C; PFK-P; Pfkp", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, platelet type; 2.7.1.11; 6-phosphofructokinase type C; ATP-PFK; PFK-C; PFK-P; Phosphofructo-1-kinase isozyme C; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type isoform 2; ATP-dependent 6-phosphofructokinase, platelet type; ATP:D-fructose 6-phosphate 1-phosphotransferase; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphohexokinase", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:56421); (R-MMU-70171)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10814514;11137296;15919810;17947660;21750661;23806337;25428506;26740625;29187734;30084848;30779550;31219806;33300544;34418053;34428180;35095764;36660859;36865524;39627609", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB]; Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells., [RefSeq, PubMed]; PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNA9;Q3U4P1;Q3U7G4;Q4KUG1;Q543K8;Q8C5I6;Q9JI86", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9WUA3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19258-1", "uniprot_id": [ { "id": "MPV17_MOUSE", "url": "https://www.uniprot.org/uniprot/P19258", "type": "external" } ], "mass": 19686.0, "length": 176, "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "Mpv17", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane protein Mpv17 isoform 1", "refseq_ac": [ { "id": "NP_001281253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281253", "type": "external" } ], "gene_names_uniprotkb": "Mpv17", "gene_names_refseq": "Mpv17; Tg.Mpv17", "protein_names_uniprotkb": "Mitochondrial inner membrane protein Mpv17; Mpv-17; Protein Mpv17", "protein_names_refseq": "mitochondrial inner membrane protein Mpv17 isoform 1; mitochondrial inner membrane protein Mpv17; protein Mpv17", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); Alport syndrome 2 (Disease Ontology:DOID:0110033); Charcot-Marie-Tooth disease type 2EE (Disease Ontology:DOID:0111559); nephrotic syndrome (Disease Ontology:DOID:1184); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:17527); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11377883;1696177;21750661;26760297;37522959;39409161;7957077;9447939", "class_list": "", "function": "MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial protein MPV17 promotes beta-cell apoptosis in diabetogenesis., [RefSeq, PubMed]; Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (By similarity). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0016020 membrane", "go_biological_process": "GO:0042592 homeostatic process;GO:0072593 reactive oxygen species metabolic process;GO:0048839 inner ear development;GO:1901858 regulation of mitochondrial DNA metabolic process;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19258-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57724-1", "uniprot_id": [ { "id": "PCBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/P57724", "type": "external" } ], "mass": 41399.0, "length": 403, "protein_name": "Poly(rC)-binding protein 4", "gene_name": "Pcbp4", "organism": "Mouse", "refseq_name": "poly(rC)-binding protein 4", "refseq_ac": [ { "id": "NP_067542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067542", "type": "external" } ], "gene_names_uniprotkb": "Pcbp4", "gene_names_refseq": "1200003L19Rik; AlphaCP-4; Pcbp4", "protein_names_uniprotkb": "Poly(rC)-binding protein 4; Alpha-CP4", "protein_names_refseq": "alpha-CP4; poly(rC)-binding protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:59092)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10936052;21750661;26915821;31219806", "class_list": "", "function": "Single-stranded nucleic acid binding protein that binds preferentially to oligo dC., [UniProtKB, UniProtKB, UniProtKB]; The p53-PCBP4-ZFP871 axis represents a novel feedback loop in the p53 pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91VR3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043488 regulation of mRNA stability;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P57724-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMH3-1", "uniprot_id": [ { "id": "NEUR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMH3", "type": "external" } ], "mass": 42403.0, "length": 379, "protein_name": "Sialidase-2", "gene_name": "Neu2", "organism": "Mouse", "refseq_name": "sialidase-2", "refseq_ac": [ { "id": "NP_001153636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153636", "type": "external" } ], "gene_names_uniprotkb": "Neu2", "gene_names_refseq": "MBS; MSS; MTS; Neu2", "protein_names_uniprotkb": "Sialidase-2; 3.2.1.18; Cytosolic sialidase; MSS; MTS; Mouse skeletal muscle sialidase; Murine thymic sialidase; N-acetyl-alpha-neuraminidase 2; Neuraminidase-2", "protein_names_refseq": "N-acetyl-alpha-neuraminidase 2; brain sialidase; cystolic sialidase; cytosolic sialidase; murine thymic sialidase; sialidase-2; skeletal muscle sialidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:23956); (R-MMU-4085001); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10329453;10713120;11500029;16869890;21750661;23750721;35217678;37686385;37919243", "class_list": "glycogene;glycosylhydrolase", "function": "Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development. Publication Status: Online-Only, [RefSeq, PubMed]; Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides (PubMed:10713120). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate (By similarity). Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles (PubMed:10713120). Hydrolyzes exclusively monomeric GM1 ganglioside, but has no activity toward the miscellar form (By similarity). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages (By similarity). Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward isomer alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (By similarity)., [UniProtKB, PubMed, UniProtKB]; Lactate promotes myogenesis via activating H3K9 lactylation-dependent up-regulation of Neu2 expression., [RefSeq, PubMed]; Neu2 from thymus exhibited sialidase activity with fetuin at pH 7.0., [RefSeq, PubMed]; Our data demonstrate that IGF-1-induced myoblast differentiation and hypertrophy are driven, at least in part, by Neu2 upregulation and further support the significant role of cytosolic sialidase in myoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99NA3", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" } ], "go_molecular_function": "GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:1902494 catalytic complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006689 ganglioside catabolic process;GO:0045663 positive regulation of myoblast differentiation;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JMH3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMF3-1", "uniprot_id": [ { "id": "NDUAC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMF3", "type": "external" } ], "mass": 17086.0, "length": 145, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12", "gene_name": "Ndufa12", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndufa12", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; CI-B17.2; CIB17.2; Complex I-B17.2; NADH-ubiquinone oxidoreductase subunit B17.2", "protein_names_refseq": "", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 23 (Disease Ontology:DOID:0112087)", "pathway": " (mmu:66414); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;26495903;34428180;36288343;37453647;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TMF3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U435-1", "uniprot_id": [ { "id": "MMP25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U435", "type": "external" } ], "mass": 68496.0, "length": 615, "protein_name": "Matrix metalloproteinase-25", "gene_name": "Mmp25", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-25 isoform 1", "refseq_ac": [ { "id": "NP_001028511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028511", "type": "external" } ], "gene_names_uniprotkb": "Mmp25", "gene_names_refseq": "F730048C11Rik; Leukolysin; MMP20; MT6-MMP; Mmp25", "protein_names_uniprotkb": "Matrix metalloproteinase-25; 3.4.24.-; MMP-25", "protein_names_refseq": "matrix metalloproteinase-25 isoform 1; matrix metalloproteinase-25", "tax_id": 10090, "disease": "", "pathway": " (mmu:240047); (R-MMU-1592389); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20809987;21750661;27259858", "class_list": "", "function": "May activate progelatinase A., [UniProtKB]; These data suggest MMP-25 is a direct transcriptional target for TGF-beta3 in mouse secondary palate development and could be a target for TGF-beta3 elsewhere as well. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]; This study shows that Mmp25-null mice exhibit a defective innate immune response characterized by low sensitivity to bacterial LPS, hypergammaglobulinemia, and reduced secretion of proinflammatory molecules, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0016504 peptidase activator activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0060022 hard palate development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U435-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24822-1", "uniprot_id": [ { "id": "PPBI_MOUSE", "url": "https://www.uniprot.org/uniprot/P24822", "type": "external" } ], "mass": 60285.0, "length": 559, "protein_name": "Intestinal-type alkaline phosphatase", "gene_name": "Akp3; Iap", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Akp3; Iap; Akp-3; Akp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Intestinal-type alkaline phosphatase; 3.1.3.1; Alkaline phosphatase 3; IAP; Intestinal alkaline phosphatase", "protein_names_refseq": "", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:11648); (R-MMU-163125); (R-MMU-6811438)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;2286375", "class_list": "", "function": "Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.17.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.12", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0098552 side of membrane", "go_biological_process": "GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24822-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54901-1", "uniprot_id": [ { "id": "OX2G_MOUSE", "url": "https://www.uniprot.org/uniprot/O54901", "type": "external" } ], "mass": 31256.0, "length": 278, "protein_name": "OX-2 membrane glycoprotein", "gene_name": "Cd200", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd200; Mox2", "gene_names_refseq": "", "protein_names_uniprotkb": "OX-2 membrane glycoprotein; MRC OX-2 antigen", "protein_names_refseq": "", "tax_id": 10090, "disease": "autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (R-MMU-198933)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23602662;26495903;30899004;33300544;37507081;40885482;9434094;9457671", "class_list": "", "function": "Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity)., [UniProtKB]; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O54816;Q9JHD5", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:1905522 negative regulation of macrophage migration;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O54901-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQW6-1", "uniprot_id": [ { "id": "OLIG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQW6", "type": "external" } ], "mass": 32407.0, "length": 323, "protein_name": "Oligodendrocyte transcription factor 2", "gene_name": "Olig2", "organism": "Mouse", "refseq_name": "oligodendrocyte transcription factor 2", "refseq_ac": [ { "id": "NP_058663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058663", "type": "external" } ], "gene_names_uniprotkb": "Olig2", "gene_names_refseq": "Bhlhb1; Olg-2; Olig2; Oligo2; RK17; bHLHe19", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 2; Oligo2", "protein_names_refseq": "oligodendrocyte transcription factor 2", "tax_id": 10090, "disease": "status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:50913)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10719888;10719889;11091082;11955448;11960707;12121626;14573534;14602683;16908628;21382552;32483381;35156232;41193423", "class_list": "", "function": "Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain (PubMed:11955448, PubMed:12121626, PubMed:16908628). Works in coordination with ZNF488 to promote oligodendrocyte differentiation (PubMed:16908628). Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube (PubMed:11955448, PubMed:12121626). Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (PubMed:11955448, PubMed:12121626)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKN4", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9EQW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7R2-1", "uniprot_id": [ { "id": "PMEPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7R2", "type": "external" } ], "mass": 28716.0, "length": 260, "protein_name": "Protein TMEPAI", "gene_name": "Pmepa1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pmepa1; N4wbp4; Tmepai", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein TMEPAI; NEDD4 WW domain-binding protein 4; Prostate transmembrane protein androgen induced 1; Transmembrane prostate androgen-induced protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); gastric adenocarcinoma (Disease Ontology:DOID:3717); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (R-MMU-2173788)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11042109;20129061;21750661;24627487;37828378", "class_list": "", "function": "Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQH9", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding;GO:0070412 R-SMAD binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7R2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89023-1", "uniprot_id": [ { "id": "TPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O89023", "type": "external" } ], "mass": 61342.0, "length": 562, "protein_name": "Tripeptidyl-peptidase 1", "gene_name": "Tpp1", "organism": "Mouse", "refseq_name": "tripeptidyl-peptidase 1 preproprotein", "refseq_ac": [ { "id": "NP_034036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034036", "type": "external" } ], "gene_names_uniprotkb": "Tpp1; Cln2", "gene_names_refseq": "Cln2; LPIC; TPP-1; TPP-I; Tpp1", "protein_names_uniprotkb": "Tripeptidyl-peptidase 1; 3.4.14.9; LPIC; Lysosomal pepstatin-insensitive protease; TPP-1; TPP-I; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I", "protein_names_refseq": "ceroid-lipofuscinosis, neuronal 2; lysosomal pepstatin-insensitive protease; tripeptidyl aminopeptidase; tripeptidyl-peptidase 1 preproprotein; tripeptidyl-peptidase 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 7 (Disease Ontology:DOID:0080059); neuronal ceroid lipofuscinosis 2 (Disease Ontology:DOID:0110726)", "pathway": " (mmu:12751)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10556422;16170054;18250455;18299400;19941651;21750661;25428506;26495903;26740625;28011936;28464005;30084848;30899004;31219806;34428180;35984892;37828378;40885482;9989590", "class_list": "", "function": "Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:28464005). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a lysosomal serine protease that cleaves N-terminal tripeptides from protein substrates. The encoded preproprotein undergoes autocatalytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit a progressive neurodegeneration and a greatly shortened lifespan. At the cellular level, mice lacking the encoded protein exhibit accumulation of autofluorescent lipopigments. Mutations in the human ortholog of this gene cause classical late-infantile neuronal ceroid lipofuscinosis. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q543Q8;Q9QUS7", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008240 tripeptidyl-peptidase activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0045121 membrane raft;GO:0055037 recycling endosome;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development;GO:0030855 epithelial cell differentiation;GO:0050885 neuromuscular process controlling balance;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "O89023-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37040-1", "uniprot_id": [ { "id": "NCPR_MOUSE", "url": "https://www.uniprot.org/uniprot/P37040", "type": "external" } ], "mass": 77044.0, "length": 678, "protein_name": "NADPH--cytochrome P450 reductase", "gene_name": "Por", "organism": "Mouse", "refseq_name": "NADPH--cytochrome P450 reductase isoform 1", "refseq_ac": [ { "id": "NP_032924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032924", "type": "external" } ], "gene_names_uniprotkb": "Por", "gene_names_refseq": "4933424M13Rik; CPR; CYPOR; P450R; Por", "protein_names_uniprotkb": "NADPH--cytochrome P450 reductase; 1.6.2.4; CPR; P450R", "protein_names_refseq": "NADH cytochrome P450 oxydoreductase; NADPH--cytochrome P450 reductase isoform 1; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase", "tax_id": 10090, "disease": "Antley-Bixler syndrome with disordered steroidogenesis (Disease Ontology:DOID:0050462); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cytochrome P450 oxidoreductase deficiency (Disease Ontology:DOID:0080925)", "pathway": " (mmu:18984)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21750661;25605945;26740625;26898952;27863990;30084848;30685480;31219806;33321093;34428180;37453647;8011664", "class_list": "", "function": "Hepatic cytochrome b5/P450 reductase contribute to the bioactivation of ellipticine in vitro, but not in vivo., [RefSeq, PubMed]; Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen, [RefSeq, PubMed]; Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1., [RefSeq, PubMed]; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5., [UniProtKB, HAMAP]; We observed that miR-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0009055 electron transfer activity;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007584 response to nutrient;GO:0043066 negative regulation of apoptotic process;GO:0019395 fatty acid oxidation;GO:0032332 positive regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P37040-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIK5-1", "uniprot_id": [ { "id": "PEAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIK5", "type": "external" } ], "mass": 110580.0, "length": 1034, "protein_name": "Platelet endothelial aggregation receptor 1", "gene_name": "Pear1", "organism": "Mouse", "refseq_name": "platelet endothelial aggregation receptor 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001027585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027585", "type": "external" } ], "gene_names_uniprotkb": "Pear1; Jedi; Megf12", "gene_names_refseq": "3110045G13Rik; Jedi-1; Megf12; Pear1", "protein_names_uniprotkb": "Platelet endothelial aggregation receptor 1; Jagged and Delta protein; Multiple EGF-like domains protein 12; Multiple epidermal growth factor-like domains protein 12; Protein Jedi; mPEAR1", "protein_names_refseq": "Jedi; jagged and Delta protein; mPEAR1; multiple EGF-like domains protein 12; multiple epidermal growth factor-like domains protein 12; platelet endothelial aggregation receptor 1 isoform a precursor; protein Jedi", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:73182)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15851471;17226770;19915564;21750661;22993420;24743597;36792666;37828378;37952151", "class_list": "", "function": "A cellular and molecular mechanism by which neuronal corpses are culled during dorsal root ganglia development involves Jedi protein, [RefSeq, PubMed]; Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway., [RefSeq, PubMed]; Jedi-1 signals through recruitment of GULP, which promotes phagocytosis through a noncanonical phosphoclathrin-dependent mechanism., [RefSeq, PubMed]; Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone., [RefSeq, PubMed]; Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (PubMed:17226770)., [UniProtKB, PubMed, PubMed]; SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi: 10.1038/s41467-023-37005-x. PMID: 36932061] Publication Status: Online-Only, [RefSeq, PubMed]; These results indicated that both Jedi-1 and MEGF10 can mediate phagocytosis independently through the recruitment of Syk., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3URX7;Q6KAQ6;Q8CGA7;Q8VHF4;Q8VHL7", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0070527 platelet aggregation;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010572 positive regulation of platelet activation;GO:0043654 recognition of apoptotic cell", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VIK5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33215-1", "uniprot_id": [ { "id": "NEDD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P33215", "type": "external" } ], "mass": 71292.0, "length": 660, "protein_name": "Protein NEDD1", "gene_name": "Nedd1", "organism": "Mouse", "refseq_name": "protein NEDD1", "refseq_ac": [ { "id": "NP_032708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032708", "type": "external" } ], "gene_names_uniprotkb": "Nedd1; Nedd-1", "gene_names_refseq": "Nedd1", "protein_names_uniprotkb": "Protein NEDD1; NEDD-1; Neural precursor cell expressed developmentally down-regulated protein 1", "protein_names_refseq": "NEDD-1; neural precursor cell expressed developmentally down-regulated protein 1; protein NEDD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17997); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "12727642;1378265;19144319;20173027;21183079;21750661;23106787;26495903;28528544;32782141;36852467", "class_list": "", "function": "Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system (PubMed:1378265)., [UniProtKB, UniProtKB, PubMed]; The mice treated with small interfering (si) RNA targeting NEDD1 by the atelocollagen-mediated delivery system showed a significantly prolonged survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXV3;Q8BN12;Q8BN86;Q8BQL9;Q9CWK2", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0031109 microtubule polymerization or depolymerization;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33215-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXY9-1", "uniprot_id": [ { "id": "PEX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXY9", "type": "external" } ], "mass": 42224.0, "length": 372, "protein_name": "Peroxisomal biogenesis factor 3", "gene_name": "Pex3", "organism": "Mouse", "refseq_name": "peroxisomal biogenesis factor 3 isoform 1", "refseq_ac": [ { "id": "NP_064345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064345", "type": "external" } ], "gene_names_uniprotkb": "Pex3", "gene_names_refseq": "1700014F15Rik; 2810027F19Rik; 2900010N04Rik; Pex3", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 3; Peroxin-3; Peroxisomal assembly protein PEX3", "protein_names_refseq": "peroxin-3; peroxisomal assembly protein 3; peroxisomal assembly protein PEX3; peroxisomal biogenesis factor 3 isoform 1", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 10A (Disease Ontology:DOID:0080484); Peroxisome biogenesis disorder 10B (Disease Ontology:DOID:0081440); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (mmu:56535); (R-MMU-1369062); (R-MMU-9603798)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10839463;21750661;31219806;34428180;36291074;38951640", "class_list": "", "function": "Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3. Publication Status: Online-Only, [RefSeq, PubMed]; The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0007031 peroxisome organization;GO:0016557 peroxisome membrane biogenesis;GO:0045046 protein import into peroxisome membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QXY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPE2-1", "uniprot_id": [ { "id": "MTMR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPE2", "type": "external" } ], "mass": 208693.0, "length": 1867, "protein_name": "Myotubularin-related protein 5", "gene_name": "Sbf1", "organism": "Mouse", "refseq_name": "myotubularin-related protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001074499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074499", "type": "external" } ], "gene_names_uniprotkb": "Sbf1; Kiaa3020; Mtmr5", "gene_names_refseq": "2610510A08Rik; B230113C15Rik; Mtmr5; Sbf1; mKIAA3020", "protein_names_uniprotkb": "Myotubularin-related protein 5; Inactive phosphatidylinositol 3-phosphatase 5; SET-binding factor 1; Sbf1", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 5; myotubularin-related protein 5 isoform 2; myotubularin-related protein 5", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4B3 (Disease Ontology:DOID:0110194); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:77980); (R-MMU-1483248); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11994405;16452087;17242355;20173027;21750661;25428506;25605945;30084848;30779550;31219806;31599954;33300544;34203471;34428180;34718573;36210013", "class_list": "", "function": "Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Acts as a suppressor of autophagy in neurons (By similarity). Together with its binding partner, the phosphatase MTMR2, plays a role in dephosphorylation of phosphoinositides critical for autophagy initiation and autophagosome maturation (By similarity). Plays a role in positively regulating late-stage radial sorting of large caliber axons, a process leading to myelination by Schwann cells, possibly via regulating endosomal trafficking (PubMed:34718573). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (By similarity)., [UniProtKB, UniProtKB, PubMed]; Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination., [RefSeq, PubMed]; Expressed at high levels in seminiferous tubules of the testis; mice that are nullizygous for Sbf1 exhibit male infertility characterized by azoospermia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RXQ1;B2RXX4;B7ZWK2;Q4QQM2;Q8BK68;Q8K2Z0", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0043495 protein-membrane adaptor activity;GO:0001691 pseudophosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body;GO:0043005 neuron projection", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6ZPE2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z104-1", "uniprot_id": [ { "id": "HM20B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z104", "type": "external" } ], "mass": 35870.0, "length": 317, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related", "gene_name": "Hmg20b", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform c", "refseq_ac": [ { "id": "NP_001156637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156637", "type": "external" } ], "gene_names_uniprotkb": "Hmg20b; Braf35; Hmgx2; Smarce1r", "gene_names_refseq": "BRAF35; Hmg20b; Hmgx2; Hmgxb2; Smarce1r", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; BRCA2-associated factor 35; HMG box-containing protein 20B; SMARCE1-related protein; Structural DNA-binding protein BRAF35", "protein_names_refseq": "BRCA2-associated factor 35; HMG box-containing protein 20B; SMARCE1-related protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform c; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; high mobility group 20 B; high mobility group protein 20 B; structural DNA-binding protein BRAF35", "tax_id": 10090, "disease": "", "pathway": " (mmu:15353); (R-MMU-3214815); (R-MMU-983231)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10486208;10773667;20530487;21750661;34428180", "class_list": "", "function": "Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NSF7;Q9NSF8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0002111 BRCA2-BRAF35 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045666 positive regulation of neuron differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z104-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LS1-1", "uniprot_id": [ { "id": "MMAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LS1", "type": "external" } ], "mass": 32995.0, "length": 296, "protein_name": "Cobalamin trafficking protein CblD", "gene_name": "Mmadhc", "organism": "Mouse", "refseq_name": "cobalamin trafficking protein CblD isoform 1", "refseq_ac": [ { "id": "NP_598600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598600", "type": "external" } ], "gene_names_uniprotkb": "Mmadhc", "gene_names_refseq": "2010311D03Rik; CblD; Mmadhc", "protein_names_uniprotkb": "Cobalamin trafficking protein CblD; CblD; Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial", "protein_names_refseq": "cobalamin trafficking protein CblD isoform 1; cobalamin trafficking protein CblD; methylmalonic aciduria and homocystinuria type D homolog, mitochondrial", "tax_id": 10090, "disease": "methylmalonic aciduria and homocystinuria type cblD (Disease Ontology:DOID:0050716)", "pathway": " (mmu:109129); (R-MMU-9759218)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21536470;21750661;22872234;26483544;34428180;35820727", "class_list": "", "function": "During organogenesis Mmachc and Mmadhc may interact in only a subset of cells., [RefSeq, PubMed]; Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LS1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFV2-1", "uniprot_id": [ { "id": "PCID2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFV2", "type": "external" } ], "mass": 46132.0, "length": 399, "protein_name": "PCI domain-containing protein 2", "gene_name": "Pcid2", "organism": "Mouse", "refseq_name": "PCI domain-containing protein 2", "refseq_ac": [ { "id": "NP_848823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848823", "type": "external" } ], "gene_names_uniprotkb": "Pcid2", "gene_names_refseq": "A730042J05Rik; Pcid2", "protein_names_uniprotkb": "PCI domain-containing protein 2; CSN12-like protein", "protein_names_refseq": "CSN12-like protein; PCI domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234069)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "20173027;20870947;21750661;24167073;25428506;25428507;29138493;30084848;30779550;31219806;34203471;34428180;35820727", "class_list": "", "function": "Pcid2 is essential for B cell survival through the regulation of MAD2 expression during B cell differentiation, [RefSeq, PubMed]; Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation., [RefSeq, PubMed]; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (PubMed:29138493). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (PubMed:29138493)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q147Z6;Q8C951", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport;GO:0048536 spleen development;GO:0006368 transcription elongation by RNA polymerase II;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BFV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE90-1", "uniprot_id": [ { "id": "MP2K7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE90", "type": "external" } ], "mass": 59312.0, "length": 535, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7", "gene_name": "Map2k7", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 7 isoform 1", "refseq_ac": [ { "id": "NP_001036022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036022", "type": "external" } ], "gene_names_uniprotkb": "Map2k7; Mkk7", "gene_names_refseq": "5930412N11Rik; JNKK 2; Jnkk2; MAPKK 7; MEK 7; Map2k7; Mapkk7; Mek7; Mkk7; Prkmk7; sek2", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 7; 2.7.12.2; JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; c-Jun N-terminal kinase kinase 2", "protein_names_refseq": "JNK kinase 2; JNK-activating kinase 2; MAP kinase kinase 7; MAPK/ERK kinase 7; c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7 isoform 1; dual specificity mitogen-activated protein kinase kinase 7; protein kinase, mitogen activated, kinase 7", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114); colon adenocarcinoma (Disease Ontology:DOID:234); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); schizophrenia (Disease Ontology:DOID:5419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:26400); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450321)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10629060;11390361;12624093;17496909;19144319;20801953;21333379;21750661;23963642;27084103;28111074;31219806;35275161;38115586;9312105;9384583;9405446;9535930;9733513;9891090", "class_list": "", "function": "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer., [RefSeq, PubMed]; The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35406;O35720;O35871;O35872;O54780;O70242;O70243;Q8BSP1;Q9QWG6;Q9R1Z3;Q9R1Z4;Q9R1Z5;Q9R1Z6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0008545 JUN kinase kinase activity;GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000671 regulation of motor neuron apoptotic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006970 response to osmotic stress;GO:0034612 response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CE90-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70296-1", "uniprot_id": [ { "id": "PEBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70296", "type": "external" } ], "mass": 20830.0, "length": 187, "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "Pebp1", "organism": "Mouse", "refseq_name": "phosphatidylethanolamine-binding protein 1", "refseq_ac": [ { "id": "NP_061346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061346", "type": "external" } ], "gene_names_uniprotkb": "Pebp1; Pbp; Pebp", "gene_names_refseq": "HCNP; Pbp1; Pbpr; Pbp; Pebp1; Rkip", "protein_names_uniprotkb": "Phosphatidylethanolamine-binding protein 1; HCNPpp; PEBP-1", "protein_names_refseq": "HCNPpp; PEBP-1; Raf-1 inhibitor protein; Raf-1 kinase inhibitor protein; phosphatidylethanolamine-binding protein 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); ovarian cancer (Disease Ontology:DOID:2394); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:23980); (R-MMU-5674135); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10051191;11034991;21183079;21750661;26495903;28011936;28411188;34428180;36288343;36382638;37272212;37453647;37507081;39927985", "class_list": "", "function": "AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway., [RefSeq, PubMed]; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RKIP suppresses the influenza A virusinduced airway inflammatory response via the ERK/MAPK pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8G9;Q9JJ58", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0043209 myelin sheath", "go_biological_process": "GO:0000165 MAPK cascade;GO:0001933 negative regulation of protein phosphorylation;GO:0048240 sperm capacitation;GO:0002026 regulation of the force of heart contraction;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70296-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCX5-1", "uniprot_id": [ { "id": "NEUL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCX5", "type": "external" } ], "mass": 167637.0, "length": 1563, "protein_name": "Neuralized-like protein 4", "gene_name": "Neurl4", "organism": "Mouse", "refseq_name": "neuralized-like protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001013432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013432", "type": "external" } ], "gene_names_uniprotkb": "Neurl4; Kiaa1787", "gene_names_refseq": "Neurl4", "protein_names_uniprotkb": "Neuralized-like protein 4", "protein_names_refseq": "neuralized homolog 4; neuralized-like protein 4 isoform 1; neuralized-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:216860)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;34203471", "class_list": "", "function": "Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U090;Q5NCX4;Q69ZA2;Q8R1V5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0061630 ubiquitin protein ligase activity;GO:0030701 NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5NCX5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D071-1", "uniprot_id": [ { "id": "MMS19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D071", "type": "external" } ], "mass": 113089.0, "length": 1031, "protein_name": "MMS19 nucleotide excision repair protein homolog", "gene_name": "Mms19", "organism": "Mouse", "refseq_name": "MMS19 nucleotide excision repair protein homolog isoform 1", "refseq_ac": [ { "id": "NP_082428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082428", "type": "external" } ], "gene_names_uniprotkb": "Mms19; Mms19l", "gene_names_refseq": "2410001K24Rik; 2610042O15Rik; Mms19l; Mms19", "protein_names_uniprotkb": "MMS19 nucleotide excision repair protein homolog; MET18 homolog; MMS19-like protein", "protein_names_refseq": "MET18 homolog; MMS19 (MET18 S. cerevisiae); MMS19 nucleotide excision repair protein homolog isoform 1; MMS19 nucleotide excision repair protein homolog; MMS19-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72199)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11328871;18836076;21750661;22678361;23150669;25428506;26495903;28135057;28528544;31219806;33300544;34428180;35820727;39627609", "class_list": "", "function": "Cloning of the mouse MMS19 genes and functional complementation in Saccharomyces cerevisiae, [RefSeq, PubMed]; In the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair, [RefSeq, PubMed]; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mms19 has distinct and separable functions in nucleotide excision repair and cell growth, [RefSeq, PubMed]; The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WHX3;Q925N8;Q9CWX3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0051604 protein maturation;GO:0016226 iron-sulfur cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D071-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AUR6-1", "uniprot_id": [ { "id": "MMS22_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AUR6", "type": "external" } ], "mass": 140582.0, "length": 1238, "protein_name": "Protein MMS22-like", "gene_name": "Mms22l", "organism": "Mouse", "refseq_name": "protein MMS22-like", "refseq_ac": [ { "id": "NP_955761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955761", "type": "external" } ], "gene_names_uniprotkb": "Mms22l", "gene_names_refseq": "F730047E07Rik; Gm134; Mms22l", "protein_names_uniprotkb": "Protein MMS22-like; Methyl methanesulfonate-sensitivity protein 22-like", "protein_names_refseq": "protein MMS22-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:212377)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14691545;18299400;21750661;21952136;25428506;25605945;30084848;30779550;31219806;34428180;35820727", "class_list": "", "function": "Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN61;D3YXA0;Q6R5F9;Q80UT0", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B1AUR6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z6P0-1", "uniprot_id": [ { "id": "PDIA2_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z6P0", "type": "external" } ], "mass": 58316.0, "length": 527, "protein_name": "Protein disulfide-isomerase A2", "gene_name": "Pdia2", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase A2 precursor", "refseq_ac": [ { "id": "NP_001074539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074539", "type": "external" } ], "gene_names_uniprotkb": "Pdia2; Pdip", "gene_names_refseq": "1810041F13Rik; Pdia2; Pdipl; Pdip", "protein_names_uniprotkb": "Protein disulfide-isomerase A2; 5.3.4.1; PDIp", "protein_names_refseq": "protein disulfide isomerase (pancreas) like; protein disulfide isomerase, pancreatic; protein disulfide-isomerase A2 precursor; protein disulfide-isomerase A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69191)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;14693722;21750661;22159485;9115635", "class_list": "", "function": "Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity)., [UniProtKB, UniProtKB]; Elevated Pdi expression is cis regulated and is not linked to diabetes susceptibility., [RefSeq, PubMed]; Rotavirus-protein disulfide isomerase interaction was demonstrated in vitro as well as inMA104 cells and intestinal villi from suckling mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14AV9", "ec_number_list": [], "go_molecular_function": "GO:0005496 steroid binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0070527 platelet aggregation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D3Z6P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK30-1", "uniprot_id": [ { "id": "NDUV3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK30", "type": "external" } ], "mass": 11813.0, "length": 104, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial", "gene_name": "Ndufv3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001077360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077360", "type": "external" } ], "gene_names_uniprotkb": "Ndufv3", "gene_names_refseq": "1500032D16Rik; Ndufv3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; CI-9kD; Complex I-9kD; NADH-ubiquinone oxidoreductase 9 kDa subunit", "protein_names_refseq": "CI-9kD; NADH dehydrogenase (ubiquinone) flavoprotein 3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; NADH-ubiquinone oxidoreductase 9 kDa subunit; NADH-ubiquinone oxidoreductase flavoprotein 3; complex I-9kD", "tax_id": 10090, "disease": "", "pathway": " (mmu:78330); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;27988283;34428180;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I., [UniProtKB, PubMed]; Further mass spectrometric analyses of complex I from different murine and bovine tissues showed a tissue-specific expression pattern of NDUFV3-S and NDUFV3-L. Hence, NDUFV3-S was identified as the only isoform in heart and skeletal muscle, whereas in liver, brain, and lung NDUFV3-L was expressed as the dominant isoform, together with NDUFV3-S present in all tissues analyzed, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BK30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSV4-1", "uniprot_id": [ { "id": "PGM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSV4", "type": "external" } ], "mass": 68748.0, "length": 620, "protein_name": "Phosphopentomutase", "gene_name": "Pgm2", "organism": "Mouse", "refseq_name": "phosphoglucomutase-2 isoform 1", "refseq_ac": [ { "id": "NP_079976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079976", "type": "external" } ], "gene_names_uniprotkb": "Pgm2; Pgm1", "gene_names_refseq": "3230402E02Rik; Pgm-1; Pgm1; Pgm2", "protein_names_uniprotkb": "Phosphopentomutase; 5.4.2.2; 5.4.2.7; Glucose phosphomutase 2; PGM 2; Phosphodeoxyribomutase; Phosphoglucomutase-1; Phosphoglucomutase-2", "protein_names_refseq": "glucose phosphomutase 2; phosphodeoxyribomutase; phosphoglucomutase 1; phosphoglucomutase-2 isoform 1; phosphopentomutase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66681); (R-MMU-6798695); (R-MMU-71336)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17804405;19131326;21183079;21750661", "class_list": "glycogene", "function": "Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (By similarity). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (By similarity). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (By similarity). In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0P7;Q9CRS8", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity;GO:0008973 phosphopentomutase activity;GO:0016868 intramolecular phosphotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0005978 glycogen biosynthetic process;GO:0006166 purine ribonucleoside salvage;GO:0005980 glycogen catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TSV4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI63-1", "uniprot_id": [ { "id": "MOB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI63", "type": "external" } ], "mass": 26851.0, "length": 235, "protein_name": "MOB kinase activator 2", "gene_name": "Mob2", "organism": "Mouse", "refseq_name": "MOB kinase activator 2 isoform 2", "refseq_ac": [ { "id": "NP_001334489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334489", "type": "external" } ], "gene_names_uniprotkb": "Mob2; Mmh", "gene_names_refseq": "1110017M21Rik; 2700078K21Rik; Mmh; Mob2", "protein_names_uniprotkb": "MOB kinase activator 2; Mob2 homolog; Mps one binder kinase activator-like 2; Ovary-specific MOB-like protein", "protein_names_refseq": "MOB kinase activator 2 isoform 2; Mps one binder kinase activator-like 2; mob2 homolog; ovary-specific MOB-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:101513)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21237165;21750661;34428180", "class_list": "", "function": "Stimulates the autophosphorylation and kinase activity of STK38 and STK38L., [UniProtKB, UniProtKB, UniProtKB]; Study identified Mob2 protein which plays a significant role in promoting neurite formation in Neuro2A (N2A) cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXL5;Q9CZJ5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VI63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJC8-1", "uniprot_id": [ { "id": "NIPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJC8", "type": "external" } ], "mass": 39091.0, "length": 359, "protein_name": "Magnesium transporter NIPA2", "gene_name": "Nipa2", "organism": "Mouse", "refseq_name": "magnesium transporter NIPA2 isoform 1", "refseq_ac": [ { "id": "NP_001243059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243059", "type": "external" } ], "gene_names_uniprotkb": "Nipa2; MNCb-2146", "gene_names_refseq": "2600017P10Rik; 3830408P04Rik; Nipa2", "protein_names_uniprotkb": "Magnesium transporter NIPA2; Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog", "protein_names_refseq": "magnesium transporter NIPA2 isoform 1; magnesium transporter NIPA2; non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog", "tax_id": 10090, "disease": "hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:93790); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14508708;18667602;21750661;31219806;32080264;34428180", "class_list": "", "function": "Acts as a selective Mg(2+) transporter., [UniProtKB, PubMed]; Indentification on mouse chromosome 7C, [RefSeq, PubMed]; NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; The isolation and characterization of Nipa2 in mouse distal convoluted tubule cells are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3I0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ91-1", "uniprot_id": [ { "id": "NDUA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ91", "type": "external" } ], "mass": 9331.0, "length": 84, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "gene_name": "Ndufa3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "refseq_ac": [ { "id": "NP_079624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079624", "type": "external" } ], "gene_names_uniprotkb": "Ndufa3", "gene_names_refseq": "1010001M12Rik; 1700022J01Rik; Ndufa3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; CI-B9; Complex I-B9; NADH-ubiquinone oxidoreductase B9 subunit", "protein_names_refseq": "CI-B9; Complex I-B9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; NADH-ubiquinone oxidoreductase B9 subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:66091); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;30084848;34428180;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBA7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQ91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0L1-1", "uniprot_id": [ { "id": "HSF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0L1", "type": "external" } ], "mass": 53255.0, "length": 492, "protein_name": "Heat shock factor protein 4", "gene_name": "Hsf4", "organism": "Mouse", "refseq_name": "heat shock factor protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001242971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242971", "type": "external" } ], "gene_names_uniprotkb": "Hsf4", "gene_names_refseq": "HSF 4; HSTF 4; HSTF4; Hsf4; ldis1; mHSF4", "protein_names_uniprotkb": "Heat shock factor protein 4; HSF 4; HSTF 4; Heat shock transcription factor 4; mHSF4", "protein_names_refseq": "DNA binding protein; binds heat shock DNA elements; heat shock factor 4; heat shock factor protein 4 isoform 1; heat shock factor protein 4", "tax_id": 10090, "disease": "cataract 5 multiple types (Disease Ontology:DOID:0110255); neurodegenerative disease (Disease Ontology:DOID:1289); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:26386)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10488131;15483628;16581800;21750661;31786107;34339841;37266953", "class_list": "", "function": "Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 and HSF4 are involved in regulating expression of growth factor genes., [RefSeq, PubMed]; Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression., [RefSeq, PubMed]; HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation., [RefSeq, PubMed]; Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (By similarity). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (By similarity). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (By similarity). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (PubMed:31786107)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Transcriptional activator., [UniProtKB, PubMed]; Transcriptional repressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0L2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R0L1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16675-1", "uniprot_id": [ { "id": "PPGB_MOUSE", "url": "https://www.uniprot.org/uniprot/P16675", "type": "external" } ], "mass": 53844.0, "length": 474, "protein_name": "Lysosomal protective protein", "gene_name": "Ctsa", "organism": "Mouse", "refseq_name": "lysosomal protective protein isoform b preproprotein", "refseq_ac": [ { "id": "NP_001033581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033581", "type": "external" } ], "gene_names_uniprotkb": "Ctsa; Ppgb", "gene_names_refseq": "Ctsa; PPCA; Ppgb", "protein_names_uniprotkb": "Lysosomal protective protein; 3.4.16.5; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; PPCA; Protective protein cathepsin A; Protective protein for beta-galactosidase", "protein_names_refseq": "carboxypeptidase C; carboxypeptidase L; lysosomal protective protein isoform b preproprotein; lysosomal protective protein; protective protein cathepsin A; protective protein for beta-galactosidase", "tax_id": 10090, "disease": "brain small vessel disease 6 with leukoencephalopathy (Disease Ontology:DOID:0061236); galactosialidosis (Disease Ontology:DOID:0080540); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:19025); (R-MMU-2132295); (R-MMU-4085001); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16170054;2106523;21750661;30899004;3136930;32647007;34428180;37507081", "class_list": "glycogene", "function": "Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice., [RefSeq, PubMed]; Characterization of human PPCA, including N-terminal sequencing of the two cleavage products, [RefSeq, PubMed]; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEF6", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005764 lysosome", "go_biological_process": "GO:1904715 negative regulation of chaperone-mediated autophagy;GO:0006508 proteolysis;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P16675-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23249-1", "uniprot_id": [ { "id": "MOV10_MOUSE", "url": "https://www.uniprot.org/uniprot/P23249", "type": "external" } ], "mass": 113583.0, "length": 1004, "protein_name": "RNA helicase MOV-10", "gene_name": "Mov10", "organism": "Mouse", "refseq_name": "putative helicase MOV-10 isoform b", "refseq_ac": [ { "id": "NP_001156913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156913", "type": "external" } ], "gene_names_uniprotkb": "Mov10; Gb110", "gene_names_refseq": "Mov-10; Mov10", "protein_names_uniprotkb": "RNA helicase MOV-10; 5.6.2.5; Moloney leukemia virus 10 protein; RNA 5'-3' helicase MOV-10", "protein_names_refseq": "moloney leukemia virus 10 protein; putative helicase MOV-10 isoform b; putative helicase MOV-10", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:17454)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "1899287;19144319;21750661;25605945;28662698;31219806;34065512;34428180;34847178;34887587;35157734;36001654;37126510;37453647;40021952;8065313", "class_list": "", "function": "5'-3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (PubMed:28662698). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity)., [UniProtKB, UniProtKB, PubMed]; FMRP and MOV10 regulate Dicer1 expression and dendrite development. Publication Status: Online-Only, [RefSeq, PubMed]; Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response. Publication Status: Online-Only, [RefSeq, PubMed]; The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC64", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0032574 5'-3' RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0051607 defense response to virus;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0035195 miRNA-mediated post-transcriptional gene silencing;GO:0061014 positive regulation of mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P23249-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D110-1", "uniprot_id": [ { "id": "MTHFS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D110", "type": "external" } ], "mass": 23202.0, "length": 203, "protein_name": "5-formyltetrahydrofolate cyclo-ligase", "gene_name": "Mthfs", "organism": "Mouse", "refseq_name": "5-formyltetrahydrofolate cyclo-ligase isoform 1", "refseq_ac": [ { "id": "NP_081105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081105", "type": "external" } ], "gene_names_uniprotkb": "Mthfs", "gene_names_refseq": "1110034I12Rik; 2310020H23Rik; Mthfs", "protein_names_uniprotkb": "5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; 6.3.3.2; MTHFS; Methenyl-THF synthetase", "protein_names_refseq": "5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase isoform 1; 5-formyltetrahydrofolate cyclo-ligase; methenyl-THF synthetase", "tax_id": 10090, "disease": "", "pathway": " (mmu:107885); (R-MMU-196757)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17055997;21750661", "class_list": "", "function": "Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity)., [UniProtKB]; Expression of the MTHFS cDNA in MCF-7 cells increased the concentration of NADA required to deplete cellular folate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KF82", "ec_number_list": [ { "id": "6.3.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.3.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003690 double-stranded DNA binding;GO:0005542 folic acid binding;GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0009396 folic acid-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D110-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33434-1", "uniprot_id": [ { "id": "MMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P33434", "type": "external" } ], "mass": 74102.0, "length": 662, "protein_name": "72 kDa type IV collagenase", "gene_name": "Mmp2", "organism": "Mouse", "refseq_name": "72 kDa type IV collagenase preproprotein", "refseq_ac": [ { "id": "NP_032636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032636", "type": "external" } ], "gene_names_uniprotkb": "Mmp2", "gene_names_refseq": "Clg4a; GelA; MMP-2; Mmp2", "protein_names_uniprotkb": "72 kDa type IV collagenase; 3.4.24.24; 72 kDa gelatinase; Gelatinase A; MMP-2; Matrix metalloproteinase-2", "protein_names_refseq": "72 kDa gelatinase; 72 kDa type IV collagenase preproprotein; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; gelatinase A; matrix metalloproteinase 2", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); aortic valve disease 2 (Disease Ontology:DOID:0080334); COVID-19 (Disease Ontology:DOID:0080600); Sweet syndrome (Disease Ontology:DOID:0080746); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); keratoconus (Disease Ontology:DOID:10126); prostate cancer (Disease Ontology:DOID:10283); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); leiomyoma (Disease Ontology:DOID:127); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); alcohol use disorder (Disease Ontology:DOID:1574); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); hemangioma (Disease Ontology:DOID:255); transitional cell carcinoma (Disease Ontology:DOID:2671); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); endometriosis (Disease Ontology:DOID:289); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); heart valve disease (Disease Ontology:DOID:4079); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); conjunctivitis (Disease Ontology:DOID:6195); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); pyoderma gangrenosum (Disease Ontology:DOID:8553); cholesteatoma (Disease Ontology:DOID:869); vascular dementia (Disease Ontology:DOID:8725); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); cutaneous leishmaniasis (Disease Ontology:DOID:9111); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:17390); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-3928665); (R-MMU-9009391)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "1373140;21750661;22509276;2744464;28011936;34428180;37828378", "class_list": "", "function": "Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways., [UniProtKB, PubMed]; PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity)., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]., [RefSeq]; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 83, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0007162 negative regulation of cell adhesion;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33434-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RPV6-1", "uniprot_id": [ { "id": "MMRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RPV6", "type": "external" } ], "mass": 136106.0, "length": 1210, "protein_name": "Multimerin-1", "gene_name": "Mmrn1", "organism": "Mouse", "refseq_name": "multimerin-1 isoform b precursor", "refseq_ac": [ { "id": "NP_001156979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156979", "type": "external" } ], "gene_names_uniprotkb": "Mmrn1", "gene_names_refseq": "4921530G03Rik; Emilin4; Mmrn1; Mmrn", "protein_names_uniprotkb": "Multimerin-1", "protein_names_refseq": "multimerin-1 isoform b precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:70945); (R-MMU-114608); (R-MMU-5173105)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15177571;20138333;21750661;26495903;33083886;33179420;39627609", "class_list": "", "function": "Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Increased Expression of the Multimerin-1 Gene in alpha-Synuclein Knokout Mice., [RefSeq, PubMed]; Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion., [RefSeq, PubMed]; Our data suggest that multimerin 1 supports platelet adhesive functions and thrombus formation, which will be important to verify by generating and testing selective multimerin 1 deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 18, "predicted_n_glycosites": 15, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q6KDN2;Q80VQ7;Q9D5S2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0031091 platelet alpha granule;GO:1990972 multimerin complex", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0033627 cell adhesion mediated by integrin;GO:0061045 negative regulation of wound healing;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:1901731 positive regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B2RPV6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLI3-1", "uniprot_id": [ { "id": "MMEL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLI3", "type": "external" } ], "mass": 88700.0, "length": 765, "protein_name": "Membrane metallo-endopeptidase-like 1", "gene_name": "Mmel1", "organism": "Mouse", "refseq_name": "membrane metallo-endopeptidase-like 1", "refseq_ac": [ { "id": "NP_038811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038811", "type": "external" } ], "gene_names_uniprotkb": "Mmel1; Nep2; Nl1; Sep", "gene_names_refseq": "Mell1; Mmel1; NEP2(m); NEP2; NEPII; NL-1; NL2; Nl1; SEP", "protein_names_uniprotkb": "Membrane metallo-endopeptidase-like 1; 3.4.24.11; NEP2(m); NEP2(s); NEP2; NEPII; NEPLP; NL-1; NL2; Neprilysin II; Neprilysin-2 secreted; Neprilysin-2; Neprilysin-like 1; Neprilysin-like peptidase; Soluble secreted endopeptidase", "protein_names_refseq": "NEPLP alpha; NEPLP beta; NEPLP gamma; mel transforming oncogene-like 1; membrane metallo-endopeptidase-like 1; neprilysin 2; neprilysin II; neprilysin-like 1; neprilysin-like peptidase; soluble secreted endopeptidase", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (mmu:27390)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10542292;10749671;11278416;15121861;16081046;21750661;25510509;25991605;27369050;29191928;33548010;34428180", "class_list": "", "function": "Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond., [UniProtKB, PubMed, PubMed]; Modification of the structure of the C-terminal region will either impair substrate hydrolysis or completely abolish the secretion and enzymatic activity of the secreted isoform of rat NEP2., [RefSeq, PubMed]; Neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes, [RefSeq, PubMed]; One of the roles of NL1 in mice is related to sperm function. NL1 modulates the processes of fertilization and early embryonic development in vivo., [RefSeq, PubMed]; Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Abeta transfer receptor expression in mouse brain microvessels., [RefSeq, PubMed]; Sustained Rho activation in NEP(-/-) pulmonary artery smooth muscle cells is associated with a decrease in SM-protein levels and increased migration and proliferation., [RefSeq, PubMed]; These studies help to characterize our complex transgenic model of NEP overexpression and further demonstrate NEP's protective effects against plasma extravasation., [RefSeq, PubMed]; This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the Neprilysin in mice., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U495;Q9ERK2;Q9ERK3;Q9QZV6;Q9QZV7", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLI3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4P9-1", "uniprot_id": [ { "id": "MRP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4P9", "type": "external" } ], "mass": 163735.0, "length": 1501, "protein_name": "ATP-binding cassette sub-family C member 10", "gene_name": "Abcc10", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 10 isoform 3", "refseq_ac": [ { "id": "NP_001334325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334325", "type": "external" } ], "gene_names_uniprotkb": "Abcc10; Mrp7", "gene_names_refseq": "Abcc10; Mrp7; mFLJ00002", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 10; 7.6.2.2; 7.6.2.3; Multidrug resistance-associated protein 7", "protein_names_refseq": "ATP-binding cassette sub-family C member 10 isoform 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; multidrug resistance-associated protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:224814); (R-MMU-382556)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11943485;17203221;21576088;21750661;34428180;36430292;40010341", "class_list": "", "function": "ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). Mediates intercellular propagation of antiviral immune signaling in early stages of infection (PubMed:40010341). In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit viral replicationPubMed:40010341 (PubMed:40010341). This innate signaling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection (PubMed:40010341)., [UniProtKB, UniProtKB, PubMed]; Abcc10 is dispensable for health and viability and it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues, [RefSeq, PubMed]; MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma, [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCQ0;Q3V0D1;Q8R4S1", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0045087 innate immune response;GO:0055085 transmembrane transport;GO:0015711 organic anion transport;GO:0006691 leukotriene metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4P9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AGX3-1", "uniprot_id": [ { "id": "PRD11_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AGX3", "type": "external" } ], "mass": 63383.0, "length": 565, "protein_name": "PR domain-containing protein 11", "gene_name": "Prdm11", "organism": "Mouse", "refseq_name": "PR domain-containing protein 11 isoform 3", "refseq_ac": [ { "id": "NP_001171007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171007", "type": "external" } ], "gene_names_uniprotkb": "Prdm11", "gene_names_refseq": "8030443D09Rik; Gm29694; Gm707; Prdm11", "protein_names_uniprotkb": "PR domain-containing protein 11; 2.1.1.-", "protein_names_refseq": "PR domain-containing protein 11 isoform 3; PR domain-containing protein 11; zinc finger protein 862 pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042784)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;23978475;25499759", "class_list": "", "function": "May be involved in transcription regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PRDM11, in contrast to PRDM3 and PRDM16, is not directly involved in regulation of HSPCs in mice., [RefSeq, PubMed]; We characterize PRDM11 as a putative novel tumor suppressor that controls the expression of key oncogenes, and we add new mechanistic insight into B-cell lymphomagenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AGX2;A2AGX4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AGX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZJ9-1", "uniprot_id": [ { "id": "HYAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZJ9", "type": "external" } ], "mass": 52109.0, "length": 462, "protein_name": "Hyaluronidase-1", "gene_name": "Hyal1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hyal1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronidase-1; 3.2.1.35; Hyal-1; Hyaluronoglucosaminidase-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "mucopolysaccharidosis IX (Disease Ontology:DOID:0050809); mucopolysaccharidosis (Disease Ontology:DOID:12798); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:15586); (R-MMU-2024101); (R-MMU-2160916)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11929860;11960552;21750661;9503017", "class_list": "glycogene;glycosylhydrolase", "function": "May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 52, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AV90;O70229;Q8CE62;Q8QZX3;Q8VBW7;Q8VDK0", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0052757 chondroitin hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0036117 hyaluranon cable;GO:0005576 extracellular region", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006954 inflammatory response;GO:0030307 positive regulation of cell growth;GO:0045785 positive regulation of cell adhesion;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZJ9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHJ8-1", "uniprot_id": [ { "id": "ICOSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHJ8", "type": "external" } ], "mass": 35960.0, "length": 322, "protein_name": "ICOS ligand", "gene_name": "Icoslg; Icosl", "organism": "Mouse", "refseq_name": "ICOS ligand precursor", "refseq_ac": [ { "id": "NP_056605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056605", "type": "external" } ], "gene_names_uniprotkb": "Icoslg; Icosl; B7h2; B7h; B7rp1; Icosl", "gene_names_refseq": "B7-H2; B7RP-1; B7h; GI50; GL50-B; GL50; ICOS-L; Icoslg; Icosl; LICOS; Ly115l; mKIAA0653", "protein_names_uniprotkb": "ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; LICOS", "protein_names_refseq": "B7 homolog 2; B7-like protein Gl50; B7-related protein 1; ICOS ligand precursor", "tax_id": 10090, "disease": "immunodeficiency 119 (Disease Ontology:DOID:0061085)", "pathway": " (mmu:50723); (R-MMU-9927354)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10549624;10617205;10657606;11390480;18250455;21750661;21913724;26495903;27802388;28011936;30084848;32069316;34428180;35984892;38077334;38980909;39044218", "class_list": "", "function": "Ligand for the T-cell-specific cell surface receptor ICOS (PubMed:10549624, PubMed:10617205, PubMed:10657606). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; also induces B-cell proliferation and differentiation into plasma cells (PubMed:10549624, PubMed:10617205, PubMed:10657606). Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype., [UniProtKB, PubMed, PubMed, PubMed]; MiR-155-targeted IcosL controls tumor rejection. Erratum:[Proc Natl Acad Sci U S A. 2024 Sep 17;121(38):e2416854121. doi: 10.1073/pnas.2416854121. PMID: 39250674], [RefSeq, PubMed]; Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis. Publication Status: Online-Only, [RefSeq, PubMed]; The impact of ICOSL/ICOS pathway-regulated long non-coding RNAs on liver fibrosis in mice infected with Schistosoma japonicum. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0045190 isotype switching", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9JHJ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BDB7-1", "uniprot_id": [ { "id": "IF44L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9BDB7", "type": "external" } ], "mass": 49680.0, "length": 447, "protein_name": "Interferon-induced protein 44-like", "gene_name": "Ifi44l", "organism": "Mouse", "refseq_name": "interferon-induced protein 44-like", "refseq_ac": [ { "id": "NP_112735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112735", "type": "external" } ], "gene_names_uniprotkb": "Ifi44l; H28", "gene_names_refseq": "H-28; H28-1; H28; Ifi44l; NS1178", "protein_names_uniprotkb": "Interferon-induced protein 44-like; IFL8", "protein_names_refseq": "H28c minor histocompatibility antigen 1; histocompatibility 28; interferon-induced protein 44-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:15061); (R-MMU-9909505)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11021531;12393464;12845499;21525387;21750661;21900176;31219806;32611756", "class_list": "", "function": "Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1., [RefSeq, PubMed]; Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus. Publication Status: Online-Only, [RefSeq, PubMed]; Precursor of the histocompatibility antigen HA-28 in BALB.B mice. More generally, minor histocompatibility antigens refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD). More specifically, HA-28 minor antigen is transcribed in the BALB.B donor but not in host C57BL/6 cells. HA-28 is presented to the donor BALB.B cell surface by Kb MHC. This complex HA-28/Kb MHC elicits cytotoxic T-cell response in C57BL/6 mice immunized with BALB.B spleen cells. It induces C57BL/6 mice cells recognition and lysis by CD8 T-cell from BALB.B mice., [UniProtKB, PubMed]; This gene encodes a minor histocompatibility antigen that is involved in tissue graft rejection and is polymorphic in different mouse strains. The 5' region of this gene, including the translational start codon and the first 293 amino acids, is absent from the C57BL/6J genome. The encoded antigen is not thought to be expressed in C57BL/6J. [provided by RefSeq, Mar 2013]., [RefSeq]; Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity. During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (By similarity). Plays a role in the control of respiratory syncycial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756). Acts as a feedback regulator of IFN responses by negatively regulating IKBKB kinase activity through interaction with FKBP5 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SP46", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006955 immune response;GO:0051607 defense response to virus;GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9BDB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1J3-1", "uniprot_id": [ { "id": "NFS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1J3", "type": "external" } ], "mass": 50570.0, "length": 459, "protein_name": "Cysteine desulfurase", "gene_name": "Nfs1", "organism": "Mouse", "refseq_name": "cysteine desulfurase isoform 1", "refseq_ac": [ { "id": "NP_035041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035041", "type": "external" } ], "gene_names_uniprotkb": "Nfs1; Nifs", "gene_names_refseq": "Nfs1; m-Nfs1; m-Nfsl", "protein_names_uniprotkb": "Cysteine desulfurase; 2.8.1.7; m-Nfs1", "protein_names_refseq": "cysteine desulfurase isoform 1; cysteine desulfurase, mitochondrial; nifS-like (sic); nitrogen fixation gene, yeast homolog 1", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 52 (Disease Ontology:DOID:0070425)", "pathway": " (mmu:18041); (R-MMU-1362409); (R-MMU-947581); (R-MMU-9854311); (R-MMU-9865881)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "16787928;21298097;21750661;25597503;29168506;34428180;37507081;9738949", "class_list": "", "function": "Mitochondrial cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:25597503). The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (By similarity). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (PubMed:25597503). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; NFS1 maintains the iron sulfur clusters in proteins that are essential for protecting them from oxidative damage; inactivating NFS1 or iron sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells Erratum:[Nature. 2022 Sep;609(7929):E12. doi: 10.1038/s41586-022-05323-7. PMID: 36104569], [RefSeq, PubMed]; There is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6I5", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0031071 cysteine desulfurase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1J3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1F5-1", "uniprot_id": [ { "id": "HYI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1F5", "type": "external" } ], "mass": 30449.0, "length": 277, "protein_name": "Putative hydroxypyruvate isomerase", "gene_name": "Hyi", "organism": "Mouse", "refseq_name": "putative hydroxypyruvate isomerase", "refseq_ac": [ { "id": "NP_080877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080877", "type": "external" } ], "gene_names_uniprotkb": "Hyi", "gene_names_refseq": "2700033B16Rik; 6430559E15Rik; HT036; Hyi", "protein_names_uniprotkb": "Putative hydroxypyruvate isomerase; 5.3.1.22", "protein_names_refseq": "hydroxypyruvate isomerase homolog; putative hydroxypyruvate isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68180)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9C1;Q497S8", "ec_number_list": [ { "id": "5.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.22", "type": "external" } ], "go_molecular_function": "GO:0008903 hydroxypyruvate isomerase activity", "go_cellular_component": "", "go_biological_process": "GO:0046487 glyoxylate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q6R7-1", "uniprot_id": [ { "id": "E9Q6R7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q6R7", "type": "external" } ], "mass": 392706.0, "length": 3430, "protein_name": "Utrophin", "gene_name": "Utrn", "organism": "Mouse", "refseq_name": "utrophin", "refseq_ac": [ { "id": "NP_035812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035812", "type": "external" } ], "gene_names_uniprotkb": "Utrn", "gene_names_refseq": "DRP; Dmdl; Utrn", "protein_names_uniprotkb": "Utrophin; Dystrophin-related protein 1", "protein_names_refseq": "G-utrophin; utrophin", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); ovarian cancer (Disease Ontology:DOID:2394); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:22288); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21750661;25428506;38564291", "class_list": "", "function": "Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in anchoring the cytoskeleton to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0016010 dystrophin-associated glycoprotein complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0001954 positive regulation of cell-matrix adhesion;GO:0090257 regulation of muscle system process;GO:0007527 adult somatic muscle development;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9Q6R7-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMD7-1", "uniprot_id": [ { "id": "MORC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMD7", "type": "external" } ], "mass": 105740.0, "length": 928, "protein_name": "MORC family CW-type zinc finger protein 4", "gene_name": "Morc4", "organism": "Mouse", "refseq_name": "MORC family CW-type zinc finger protein 4 isoform A", "refseq_ac": [ { "id": "NP_001180238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180238", "type": "external" } ], "gene_names_uniprotkb": "Morc4; Zcwcc2", "gene_names_refseq": "1600017G11Rik; 5630401M14Rik; Morc4; Zcwcc2", "protein_names_uniprotkb": "MORC family CW-type zinc finger protein 4; Zinc finger CW-type coiled-coil domain protein 2", "protein_names_refseq": "MORC family CW-type zinc finger protein 4 isoform A; MORC family CW-type zinc finger protein 4; zinc finger CW-type coiled-coil domain protein 2; zinc finger, CW-type with coiled-coil domain 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75746)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTG5;Q4KMM6;Q8BX95;Q9CS96", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BMD7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0QZF7-1", "uniprot_id": [ { "id": "PRCA1_MOUSE", "url": "https://www.uniprot.org/uniprot/B0QZF7", "type": "external" } ], "mass": 34900.0, "length": 307, "protein_name": "Protein PROCA1", "gene_name": "Proca1", "organism": "Mouse", "refseq_name": "protein PROCA1 isoform 1", "refseq_ac": [ { "id": "NP_001355805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355805", "type": "external" } ], "gene_names_uniprotkb": "Proca1", "gene_names_refseq": "4933404M19Rik; Proca1", "protein_names_uniprotkb": "Protein PROCA1", "protein_names_refseq": "protein PROCA1 isoform 1; protein PROCA1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216974)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0050482 arachidonate secretion;GO:0007005 mitochondrion organization;GO:0035694 mitochondrial protein catabolic process;GO:0006644 phospholipid metabolic process;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0QZF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKN5-1", "uniprot_id": [ { "id": "OLIG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKN5", "type": "external" } ], "mass": 27141.0, "length": 260, "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "Olig1", "organism": "Mouse", "refseq_name": "oligodendrocyte transcription factor 1", "refseq_ac": [ { "id": "NP_058664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058664", "type": "external" } ], "gene_names_uniprotkb": "Olig1", "gene_names_refseq": "Bhlhb6; Olg-1; Olig1; Oligo1; bHLHe21", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 1; Oligo1; Oligodendrocyte-specific bHLH transcription factor 1", "protein_names_refseq": "oligodendrocyte transcription factor 1; oligodendrocyte-specific bHLH transcription factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:50914)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10719888;10719889;11091082;11955448;41193423", "class_list": "", "function": "Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube., [UniProtKB, PubMed, PubMed]; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0014003 oligodendrocyte development;GO:0048663 neuron fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGB7-1", "uniprot_id": [ { "id": "PP4R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VGB7", "type": "external" } ], "mass": 46479.0, "length": 417, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "Ppp4r2", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform a", "refseq_ac": [ { "id": "NP_891984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891984", "type": "external" } ], "gene_names_uniprotkb": "Ppp4r2", "gene_names_refseq": "C230060M08Rik; Ppp4r2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "protein_names_refseq": "serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform a; serine/threonine-protein phosphatase 4 regulatory subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:232314); (R-MMU-5693607)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;25153642;28135057;28528544;34428180", "class_list": "", "function": "Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4G0D4;Q6P6N7;Q6PHU6;Q8BUU5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000785 chromatin", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0002244 hematopoietic progenitor cell differentiation;GO:0010569 regulation of double-strand break repair via homologous recombination;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q0VGB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32115-1", "uniprot_id": [ { "id": "PAX4_MOUSE", "url": "https://www.uniprot.org/uniprot/P32115", "type": "external" } ], "mass": 38008.0, "length": 349, "protein_name": "Paired box protein Pax-4", "gene_name": "Pax4", "organism": "Mouse", "refseq_name": "paired box protein Pax-4 isoform 2", "refseq_ac": [ { "id": "NP_001153397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153397", "type": "external" } ], "gene_names_uniprotkb": "Pax4; Pax-4", "gene_names_refseq": "Pax-4; Pax4", "protein_names_uniprotkb": "Paired box protein Pax-4", "protein_names_refseq": "paired box gene 4; paired box protein Pax-4 isoform 2; paired box protein Pax-4", "tax_id": 10090, "disease": "maturity-onset diabetes of the young type 9 (Disease Ontology:DOID:0111107); diabetic ketoacidosis (Disease Ontology:DOID:1837); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:18506)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10364449;10567552;10567553;10891400;14561778;15930104;1685142;19665969;21750661;22570716;35573999;38767572;9121556;9439631;9480859", "class_list": "", "function": "Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding transcription factor that plays a central role in the differentiation and development of type B pancreatic cells, which are located within the pancreatic islets of Langerhans responsible for the production and release of insulin (PubMed:10364449, PubMed:10567552, PubMed:10891400, PubMed:15930104, PubMed:19665969, PubMed:9121556). Mainly acts as a transcription repressor that binds to a common element in the glucagon, insulin and somatostatin promoters and inhibits their expression (PubMed:10567552, PubMed:10891400). Prevents differentiation of type A pancreatic cells, probably by repressing expression of ARX (PubMed:14561778). Competes with another transcription factor, PAX6, for this same promoter binding site (PubMed:10364449). Also plays a key role in intestinal enteroendocrine cell differentiation by (1) directly promoting differentiation of enterochromaffin cells and (2) preventing differentiation of other intestinal enteroendocrine cell types (PubMed:22570716). Prevents differentiation of other intestinal enteroendocrine cell types by repressing the expression of ARX, the master transcription factor for intestinal type-L, -N, -D, -I and -G enteroendocrine cell differentiation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Proteasome gene expression is controlled by coordinated functions of multiple transcription factors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNC7;P97341;Q9QUR1;Q9R091", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32115-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0L6-1", "uniprot_id": [ { "id": "PAOX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0L6", "type": "external" } ], "mass": 55447.0, "length": 504, "protein_name": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase", "gene_name": "Paox", "organism": "Mouse", "refseq_name": "peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1", "refseq_ac": [ { "id": "NP_722478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722478", "type": "external" } ], "gene_names_uniprotkb": "Paox; Pao", "gene_names_refseq": "2410012F02Rik; Paox; Pao", "protein_names_uniprotkb": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; 1.5.3.13; Polyamine oxidase", "protein_names_refseq": "exo-N4-amino; peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1; peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:212503); (R-MMU-141334); (R-MMU-351200); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12660232;15247269;19911805;21750661;22959971;28029774;34428180", "class_list": "", "function": "Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12660232, PubMed:28029774). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12660232)., [UniProtKB, PubMed, PubMed]; N,N'-dibenzyl-1,4-diaminobutanes, with only two nitrogens, are also substrates of polyamine oxidase., [RefSeq, PubMed]; New mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway, [RefSeq, PubMed]; Steady-state kinetics of His64 mutant proteins shows that the mutations result in a decrease of ~15-fold in the rate constant for amine oxidation., [RefSeq, PubMed]; Translated amino acid sequences of mpao and bpao have a -Pro-Arg-Leu peroxisomal targeting signal at the extreme C termini and a beta-alpha-beta FAD-binding motif is present in the N-terminal portion of mPAO., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K254", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0046592 polyamine oxidase activity;GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0046203 spermidine catabolic process;GO:0006598 polyamine catabolic process;GO:0009446 putrescine biosynthetic process;GO:0009447 putrescine catabolic process;GO:0046208 spermine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C0L6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXZ1-1", "uniprot_id": [ { "id": "NDUS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXZ1", "type": "external" } ], "mass": 19785.0, "length": 175, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "gene_name": "Ndufs4", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "refseq_ac": [ { "id": "NP_035017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035017", "type": "external" } ], "gene_names_uniprotkb": "Ndufs4", "gene_names_refseq": "6720411N02Rik; C1-18k; Ndufs4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-18 kDa; CI-AQDQ; Complex I-18 kDa; Complex I-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit", "protein_names_refseq": "CI-18 kDa; CI-AQDQ; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit; complex I-18 kDa; complex I-AQDQ", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 1 (Disease Ontology:DOID:0112074); Leigh disease (Disease Ontology:DOID:3652); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:17993); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10318868;18396137;20433953;21750661;25594180;25605945;31361958;34428180;36288343;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUB1", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0033011 perinuclear theca;GO:0045271 respiratory chain complex I;GO:0120238 sperm glycocalyx", "go_biological_process": "GO:0003016 respiratory system process;GO:0006954 inflammatory response;GO:0030534 adult behavior;GO:0045087 innate immune response;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CXZ1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC48-1", "uniprot_id": [ { "id": "PEX12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC48", "type": "external" } ], "mass": 40633.0, "length": 359, "protein_name": "Peroxisome assembly protein 12", "gene_name": "Pex12", "organism": "Mouse", "refseq_name": "peroxisome assembly protein 12", "refseq_ac": [ { "id": "NP_598786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598786", "type": "external" } ], "gene_names_uniprotkb": "Pex12", "gene_names_refseq": "Pex12", "protein_names_uniprotkb": "Peroxisome assembly protein 12; Peroxin-12", "protein_names_refseq": "peroxin-12; peroxisome assembly protein 12", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 3A (Disease Ontology:DOID:0080478); peroxisome biogenesis disorder 3B (Disease Ontology:DOID:0081241)", "pathway": " (mmu:103737); (R-MMU-8866654); (R-MMU-9033241); (R-MMU-9603798)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043335 protein unfolding;GO:0007031 peroxisome organization;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VC48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q9-1", "uniprot_id": [ { "id": "MPU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q9", "type": "external" } ], "mass": 26498.0, "length": 247, "protein_name": "Mannose-P-dolichol utilization defect 1 protein", "gene_name": "Mpdu1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mpdu1; Supl15h", "gene_names_refseq": "", "protein_names_uniprotkb": "Mannose-P-dolichol utilization defect 1 protein; SL15; Suppressor of Lec15 and Lec35 glycosylation mutation homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital disorder of glycosylation If (Disease Ontology:DOID:0080558)", "pathway": " (R-MMU-446193)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10524236;21750661;25428506;30084848;36210013;37453647", "class_list": "glycogene", "function": "Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70203;Q9R0P7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R0Q9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3F6-1", "uniprot_id": [ { "id": "MPZL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3F6", "type": "external" } ], "mass": 26058.0, "length": 237, "protein_name": "Myelin protein zero-like protein 3", "gene_name": "Mpzl3", "organism": "Mouse", "refseq_name": "myelin protein zero-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001087218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087218", "type": "external" } ], "gene_names_uniprotkb": "Mpzl3", "gene_names_refseq": "5430427F17Rik; A530065I17Rik; Mpzl3; rc; ruf", "protein_names_uniprotkb": "Myelin protein zero-like protein 3", "protein_names_refseq": "Ig-like domain-containing protein UNQ2966; myelin protein zero-like protein 3 precursor; myelin protein zero-like protein 3", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:319742)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17273165;21750661;23715724;25428506;28011936;30307058;33040410;33991450;34486148;35984892", "class_list": "", "function": "Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice., [RefSeq, PubMed]; Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling., [RefSeq, PubMed]; MPZL3 and IL17 may have a role in the pathogenesis of seborrhoeic dermatitis-like skin inflammation., [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion., [UniProtKB]; Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology., [RefSeq, PubMed]; Mpzl3 has a novel physiological role in controlling body weight regulation, energy expenditure, glycemic control, and hepatic triglyceride synthesis in mice, [RefSeq, PubMed]; Novel gene encoding a predicted adhesion protein whose mutation in the rc/rc mice likely caused the rc phenotype Erratum:[J Invest Dermatol. 2007 Nov;127(11):2678], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5H7F1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3V3F6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D379-1", "uniprot_id": [ { "id": "HYEP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D379", "type": "external" } ], "mass": 52577.0, "length": 455, "protein_name": "Epoxide hydrolase 1", "gene_name": "Ephx1", "organism": "Mouse", "refseq_name": "epoxide hydrolase 1 isoform 2", "refseq_ac": [ { "id": "NP_001299847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299847", "type": "external" } ], "gene_names_uniprotkb": "Ephx1", "gene_names_refseq": "EH; Eph-1; Eph1; Ephx1; Epxh1; mEH", "protein_names_uniprotkb": "Epoxide hydrolase 1; 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH", "protein_names_refseq": "epoxide hydratase; epoxide hydrolase 1 isoform 2; microsomal epoxide hydrolase", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); bone disease (Disease Ontology:DOID:0080001); asbestosis (Disease Ontology:DOID:10320); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); aplastic anemia (Disease Ontology:DOID:12449); Parkinson's disease (Disease Ontology:DOID:14330); respiratory system disease (Disease Ontology:DOID:1579); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13849); (R-MMU-211945)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11003708;21750661;21952136;23576753;25605945;29717038;33567578;34428180;34799735;37453647", "class_list": "", "function": "Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; High epoxide hydrolase expression is associated with colonic inflammation., [RefSeq, PubMed]; Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97869", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0019899 enzyme binding;GO:0004301 epoxide hydrolase activity;GO:0033961 cis-stilbene-oxide hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001889 liver development;GO:0009636 response to toxic substance;GO:0071385 cellular response to glucocorticoid stimulus;GO:0034312 diol biosynthetic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D379-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQX2-1", "uniprot_id": [ { "id": "NCK5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQX2", "type": "external" } ], "mass": 138170.0, "length": 1323, "protein_name": "Nck-associated protein 5-like", "gene_name": "Nckap5l", "organism": "Mouse", "refseq_name": "nck-associated protein 5-like", "refseq_ac": [ { "id": "NP_001001884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001884", "type": "external" } ], "gene_names_uniprotkb": "Nckap5l; Cep169", "gene_names_refseq": "C230021P08Rik; Cep169; Nckap5l", "protein_names_uniprotkb": "Nck-associated protein 5-like; Centrosomal protein of 169 kDa; Cep169", "protein_names_refseq": "centrosomal protein of 169 kDa; nck-associated protein 5-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:380969)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30016717", "class_list": "", "function": "Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX75;Q8R364", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0007019 microtubule depolymerization;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6GQX2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLB2-1", "uniprot_id": [ { "id": "PALS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLB2", "type": "external" } ], "mass": 77229.0, "length": 675, "protein_name": "Protein PALS1", "gene_name": "Pals1", "organism": "Mouse", "refseq_name": "protein PALS1", "refseq_ac": [ { "id": "NP_062525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062525", "type": "external" } ], "gene_names_uniprotkb": "Pals1; Mpp5", "gene_names_refseq": "3830420B02Rik; Mpp5; Pals1", "protein_names_uniprotkb": "Protein PALS1; MAGUK p55 subfamily member 5; Protein associated with Lin-7 1", "protein_names_refseq": "MAGUK p55 subfamily member 5; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5); membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); protein PALS1; protein associated with Lin-7 1", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:56217)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10753959;11927608;12527193;12545177;15140881;15234345;15241471;15316081;15558731;15677456;16519681;17182851;17920587;20237282;20399730;21145499;21183079;21750661;22398208;22645316;22872234;23001562;23893895;25428506;26404741;26657772;27466317;30084848;30779550;34203471;34428180;38265145", "class_list": "", "function": "PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells., [RefSeq, PubMed]; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851, PubMed:20237282). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (PubMed:22398208). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (PubMed:20399730, PubMed:26404741). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (PubMed:20399730). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (PubMed:20237282). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (PubMed:15234345). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (PubMed:15677456). Required for the normal polarized localization of the vesicular marker STX4 (PubMed:20237282). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0007009 plasma membrane organization;GO:0072659 protein localization to plasma membrane;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9JLB2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGI5-1", "uniprot_id": [ { "id": "PEX26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGI5", "type": "external" } ], "mass": 34016.0, "length": 305, "protein_name": "Peroxisome assembly protein 26", "gene_name": "Pex26", "organism": "Mouse", "refseq_name": "peroxisome assembly protein 26 isoform 2", "refseq_ac": [ { "id": "NP_001291702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291702", "type": "external" } ], "gene_names_uniprotkb": "Pex26", "gene_names_refseq": "4632428M11Rik; Pex26", "protein_names_uniprotkb": "Peroxisome assembly protein 26; Peroxin-26", "protein_names_refseq": "peroxin-26; peroxisome assembly protein 26 isoform 2; peroxisome assembly protein 26; peroxisome biogenesis factor 26", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 7A (Disease Ontology:DOID:0080482); Peroxisome biogenesis disorder 7B (Disease Ontology:DOID:0081436)", "pathway": " (mmu:74043); (R-MMU-9033241); (R-MMU-9603798)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane., [UniProtKB, UniProtKB]; This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGH5;Q9D661", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:1904949 ATPase complex", "go_biological_process": "GO:0043335 protein unfolding;GO:0016558 protein import into peroxisome matrix;GO:0022615 protein to membrane docking;GO:0045046 protein import into peroxisome membrane;GO:0016562 protein import into peroxisome matrix, receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97298-1", "uniprot_id": [ { "id": "PEDF_MOUSE", "url": "https://www.uniprot.org/uniprot/P97298", "type": "external" } ], "mass": 46234.0, "length": 417, "protein_name": "Pigment epithelium-derived factor", "gene_name": "Serpinf1", "organism": "Mouse", "refseq_name": "pigment epithelium-derived factor precursor", "refseq_ac": [ { "id": "NP_035470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035470", "type": "external" } ], "gene_names_uniprotkb": "Serpinf1; Pedf; Sdf3", "gene_names_refseq": "EPC-1; Pedfl; Pedf; Sdf3; Serpinf1", "protein_names_uniprotkb": "Pigment epithelium-derived factor; Caspin; PEDF; SDF-3; Serpin F1; Stromal cell-derived factor 3", "protein_names_refseq": "SDF-3; alpha-2 antiplasmin; caspin; pigment epithelium-derived factor precursor; pigment epithelium-derived factor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; serpin F1; stromal cell-derived factor 3", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); osteogenesis imperfecta type 6 (Disease Ontology:DOID:0110350); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); portal hypertension (Disease Ontology:DOID:10762); anogenital venereal wart (Disease Ontology:DOID:11168); corneal neovascularization (Disease Ontology:DOID:11382); sciatic neuropathy (Disease Ontology:DOID:11446); leukostasis (Disease Ontology:DOID:12986); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); venous tributary occlusion of retina (Disease Ontology:DOID:13514); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); retinal vein occlusion (Disease Ontology:DOID:1727); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); osteosarcoma (Disease Ontology:DOID:3347); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); brain edema (Disease Ontology:DOID:4724); melioidosis (Disease Ontology:DOID:5052); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); retinal degeneration (Disease Ontology:DOID:8466); chronic fatigue syndrome (Disease Ontology:DOID:8544); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20317)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12632345;16936108;21750661;25428506;26740625;31599954;34428180;37490993;38153666;8938438;9565647;9614124", "class_list": "", "function": "ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy., [RefSeq, PubMed]; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity., [UniProtKB, PubMed]; PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70629;O88691", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0046685 response to arsenic-containing substance;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97298-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZP3-1", "uniprot_id": [ { "id": "PNKD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZP3", "type": "external" } ], "mass": 43017.0, "length": 385, "protein_name": "Probable thioesterase PNKD", "gene_name": "Pnkd", "organism": "Mouse", "refseq_name": "probable thioesterase PNKD isoform 3", "refseq_ac": [ { "id": "NP_001034598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034598", "type": "external" } ], "gene_names_uniprotkb": "Pnkd; Brp17; Fksg19; Kiaa1184; MNCb-5687; Mr1; Tahccp2", "gene_names_refseq": "2210013N15Rik; 2810403H05Rik; Brp17; MNCb-5687; MR-1; Pnkd; Tahccp2", "protein_names_uniprotkb": "Probable thioesterase PNKD; 3.1.2.-; MR-1; Myofibrillogenesis regulator 1; Paroxysmal nonkinesiogenic dyskinesia protein", "protein_names_refseq": "brain protein 17; myofibrillogenesis regulator 1; paroxysmal nonkinesiogenic dyskinesia protein; probable hydrolase PNKD; probable thioesterase PNKD isoform 3; probable thioesterase PNKD; trans-activated by hepatitis C virus core protein 2", "tax_id": 10090, "disease": "paroxysmal nonkinesigenic dyskinesia 1 (Disease Ontology:DOID:0090049)", "pathway": " (mmu:56695)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15188498;15496428;17420335;21750661;22214848;25730884", "class_list": "", "function": "PNKD KO mice, RIM1/2 protein levels are reduced and synaptic strength is impaired. Thus, PNKD is a novel synaptic protein with a regulatory role in neurotransmitter release, [RefSeq, PubMed]; Paroxysmal non-kinesigenic dyskinesia (PNKD) is characterized by spontaneous hyperkinetic attacks that are precipitated by alcohol, coffee, stress and fatigue., [RefSeq, PubMed]; Probable thioesterase that may play a role in cellular detoxification processes; it likely acts on a yet-unknown alpha-hydroxythioester substrate. In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid at very low rate, though this reaction is not physiologically relevant in vivo., [UniProtKB, UniProtKB]; These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLE6;Q6PD45;Q8BRV8;Q920D4;Q9CSF5;Q9D765;Q9JJA3", "ec_number_list": [ { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding;GO:0016790 thiolester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0032225 regulation of synaptic transmission, dopaminergic;GO:0042053 regulation of dopamine metabolic process;GO:0046929 negative regulation of neurotransmitter secretion;GO:0050884 neuromuscular process controlling posture", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q69ZP3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZU4-1", "uniprot_id": [ { "id": "PLAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZU4", "type": "external" } ], "mass": 18810.0, "length": 167, "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "Plaat1", "organism": "Mouse", "refseq_name": "phospholipase A and acyltransferase 1", "refseq_ac": [ { "id": "NP_038779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038779", "type": "external" } ], "gene_names_uniprotkb": "Plaat1; Hrasls; Hrasrs", "gene_names_refseq": "2810012B06Rik; A-C1; HRSL1; Hrasls; Hrasrs; Plaat1", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 1; 2.3.1.-; 3.1.1.32; 3.1.1.4; HRAS-like suppressor 1; HRSL1; Phospholipid-metabolizing enzyme A-C1", "protein_names_refseq": "HRAS-like suppressor 1; Harvey rat sarcoma virus oncogene related suppressor; phospholipase A and acyltransferase 1; phospholipid-metabolizing enzyme A-C1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27281); (R-MMU-1482839)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10542256;21750661;21880860;27623847;35743156;37330992", "class_list": "", "function": "A possible enzyme activity of A-C1, [RefSeq, PubMed]; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (By similarity)., [UniProtKB, PubMed, UniProtKB]; PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity. Publication Status: Online-Only, [RefSeq, PubMed]; PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D099;Q9D0S3", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:1903008 organelle disassembly;GO:0007031 peroxisome organization;GO:0016042 lipid catabolic process;GO:0007265 Ras protein signal transduction;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNB4-1", "uniprot_id": [ { "id": "MSTRO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNB4", "type": "external" } ], "mass": 28567.0, "length": 248, "protein_name": "Protein maestro", "gene_name": "Mro", "organism": "Mouse", "refseq_name": "protein maestro isoform 1", "refseq_ac": [ { "id": "NP_001292811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292811", "type": "external" } ], "gene_names_uniprotkb": "Mro", "gene_names_refseq": "4930507C04Rik; 4933435E20Rik; Mro", "protein_names_uniprotkb": "Protein maestro; Male-specific transcription in the developing reproductive organs", "protein_names_refseq": "male-specific transcription in the developing reproductive organs; protein maestro isoform 1; protein maestro", "tax_id": 10090, "disease": "", "pathway": " (mmu:71263)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12889070;19116663;21750661", "class_list": "", "function": "Maestro is dispensable for normal male sexual development and fertility in laboratory mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3T8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97474-1", "uniprot_id": [ { "id": "PITX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97474", "type": "external" } ], "mass": 35321.0, "length": 317, "protein_name": "Pituitary homeobox 2", "gene_name": "Pitx2", "organism": "Mouse", "refseq_name": "pituitary homeobox 2 isoform c", "refseq_ac": [ { "id": "NP_001035967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035967", "type": "external" } ], "gene_names_uniprotkb": "Pitx2; Arp1; Brx1; Otlx2; Ptx2; Rgs; Rieg", "gene_names_refseq": "9430085M16Rik; Brx1b; Brx1; Munc30; Otlx2; Pitx2; Ptx2; Rieg", "protein_names_uniprotkb": "Pituitary homeobox 2; ALL1-responsive protein ARP1; BRX1 homeoprotein; Bicoid-related homeobox protein 1; Homeobox protein PITX2; Orthodenticle-like homeobox 2; Paired-like homeodomain transcription factor 2; Solurshin", "protein_names_refseq": "ALL1-responsive protein ARP1; BRX1 homeoprotein; bicoid-related homeobox protein 1; orthodenticle-like homeobox 2; paired-like homeodomain transcription factor Munc 30; pituitary homeobox 2 isoform c; pituitary homeobox 2; solurshin", "tax_id": 10090, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); anterior segment dysgenesis 4 (Disease Ontology:DOID:0080609); Axenfeld-Rieger syndrome type 1 (Disease Ontology:DOID:0110120); ring dermoid of cornea (Disease Ontology:DOID:0111548); hypothyroidism (Disease Ontology:DOID:1459); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:18741)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10585561;11319841;15475956;18373856;20019746;21750661;30084848;8944018;9147650;9347917;9539779", "class_list": "", "function": "Identification & characterization of 2 novel isoforms of PITX2, generated by alternative translation initiation (PITX2Cbeta) & alternative mRNA splicing (PITX2B2); they show similar DNA binding & trans-activation functions as other PITX2 isoforms in vitro Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the establishment of left-right asymmetry in the developing embryo., [UniProtKB, PubMed]; May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08646;O70336;P97933;Q9JLA0;Q9QXB8;Q9R1V9;Q9Z141", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0003350 pulmonary myocardium development;GO:0003171 atrioventricular valve development;GO:0021763 subthalamic nucleus development;GO:0060577 pulmonary vein morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97474-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04095-1", "uniprot_id": [ { "id": "PR2C2_MOUSE", "url": "https://www.uniprot.org/uniprot/P04095", "type": "external" } ], "mass": 25367.0, "length": 224, "protein_name": "Prolactin-2C2", "gene_name": "Prl2c2", "organism": "Mouse", "refseq_name": "prolactin-2C2 precursor", "refseq_ac": [ { "id": "NP_112468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112468", "type": "external" } ], "gene_names_uniprotkb": "Prl2c2; Mrp1; Plf1; Plf", "gene_names_refseq": "Ghd2; MRP-1; PLF-1; Plf1; Plf; Prl2c2", "protein_names_uniprotkb": "Prolactin-2C2; Mitogen-regulated protein 1; Proliferin-1", "protein_names_refseq": "growth hormone d2; mitogen-regulated protein 1; prolactin-2C2 precursor; prolactin-2C2; proliferin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18811)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10537154;11316781;16876275;21750661;25428506;3478191;6087314;8050594", "class_list": "", "function": "May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNU8;Q498A4;Q61899", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031667 response to nutrient levels;GO:0045766 positive regulation of angiogenesis;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07832-1", "uniprot_id": [ { "id": "PLK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07832", "type": "external" } ], "mass": 68301.0, "length": 603, "protein_name": "Serine/threonine-protein kinase PLK1", "gene_name": "Plk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PLK1", "refseq_ac": [ { "id": "NP_035251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035251", "type": "external" } ], "gene_names_uniprotkb": "Plk1; Plk", "gene_names_refseq": "Plk1; Plk; STPK13", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK1; 2.7.11.21; PLK-1; Polo-like kinase 1; STPK13; Serine/threonine-protein kinase 13", "protein_names_refseq": "PLK-1; serine/threonine-protein kinase 13; serine/threonine-protein kinase PLK1", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); endometriosis (Disease Ontology:DOID:289); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:18817); (R-MMU-141430); (R-MMU-141444); (R-MMU-156711); (R-MMU-162658); (R-MMU-174178); (R-MMU-176412); (R-MMU-176417); (R-MMU-2299718); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-2980767); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-68881); (R-MMU-68884); (R-MMU-69273); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 23, "publication_id_list": "18794363;21750661;22405274;22753416;25428506;25533956;26466676;27662907;27979967;28851945;29191835;29269218;29282278;30084848;30676316;31219806;34428180;35820727;38885192;7902533;8018557;8099445;9154840", "class_list": "", "function": "Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:22405274, PubMed:27979967). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (By similarity). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:22405274). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (By similarity). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (By similarity). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (By similarity). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (By similarity). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (By similarity). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (By similarity). Promotes the central spindle recruitment of ECT2 (By similarity). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (By similarity). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (By similarity). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (By similarity). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (By similarity). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (By similarity). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (By similarity). Required for kinetochore localization of BUB1B (By similarity). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (By similarity). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (By similarity). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (By similarity). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions (By similarity). Phosphorylates BORA, and thereby promotes the degradation of BORA (By similarity). Contributes to the regulation of AURKA function (By similarity). Also required for recovery after DNA damage checkpoint and entry into mitosis (By similarity). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (By similarity). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956). Phosphorylates CEP68 and is required for its degradation (By similarity). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (By similarity). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (By similarity). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (By similarity). Regulates mitotic progression by phosphorylating RIOK2 (By similarity). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (By similarity). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD. Publication Status: Online-Only, [RefSeq, PubMed]; The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0045143 homologous chromosome segregation;GO:0090435 protein localization to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q07832-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UGM2-1", "uniprot_id": [ { "id": "NEK10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UGM2", "type": "external" } ], "mass": 126058.0, "length": 1111, "protein_name": "Serine/threonine-protein kinase Nek10", "gene_name": "Nek10", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek10 isoform 1", "refseq_ac": [ { "id": "NP_001182158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182158", "type": "external" } ], "gene_names_uniprotkb": "Nek10; Gm282", "gene_names_refseq": "Gm282; Nek10", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek10; 2.7.11.1; Never in mitosis A-related kinase 10; NimA-related protein kinase 10", "protein_names_refseq": "never in mitosis A-related kinase 10; nimA-related protein kinase 10; serine/threonine-protein kinase Nek10 isoform 1; serine/threonine-protein kinase Nek10", "tax_id": 10090, "disease": "primary ciliary dyskinesia 44 (Disease Ontology:DOID:0111851)", "pathway": " (mmu:674895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20956560;21750661", "class_list": "", "function": "Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells, it is involved in the regulation of mucociliary transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:1902911 protein kinase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043406 positive regulation of MAP kinase activity;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0031954 positive regulation of protein autophosphorylation;GO:1902749 regulation of cell cycle G2/M phase transition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UGM2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQT1-1", "uniprot_id": [ { "id": "MTNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQT1", "type": "external" } ], "mass": 39411.0, "length": 369, "protein_name": "Methylthioribose-1-phosphate isomerase", "gene_name": "Mri1", "organism": "Mouse", "refseq_name": "methylthioribose-1-phosphate isomerase", "refseq_ac": [ { "id": "NP_080699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080699", "type": "external" } ], "gene_names_uniprotkb": "Mri1", "gene_names_refseq": "2410018C20Rik; Mri1", "protein_names_uniprotkb": "Methylthioribose-1-phosphate isomerase; 5.3.1.23; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "protein_names_refseq": "M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; methylthioribose-1-phosphate isomerase; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67873); (R-MMU-1237112)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;24129315;31219806;37453647", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXF6", "ec_number_list": [ { "id": "5.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.23", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIL2-1", "uniprot_id": [ { "id": "MSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIL2", "type": "external" } ], "mass": 32153.0, "length": 278, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 1", "gene_name": "Msantd1", "organism": "Mouse", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001297479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297479", "type": "external" } ], "gene_names_uniprotkb": "Msantd1", "gene_names_refseq": "A930005I04Rik; Gm144; Msantd1", "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 1", "protein_names_refseq": "myb/SANT-like DNA-binding domain-containing protein 1 isoform 2; myb/SANT-like DNA-binding domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:403174)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016604 nuclear body", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BIL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TV65-1", "uniprot_id": [ { "id": "MPND_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TV65", "type": "external" } ], "mass": 53376.0, "length": 487, "protein_name": "MPN domain-containing protein", "gene_name": "Mpnd", "organism": "Mouse", "refseq_name": "MPN domain-containing protein", "refseq_ac": [ { "id": "NP_080806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080806", "type": "external" } ], "gene_names_uniprotkb": "Mpnd", "gene_names_refseq": "E130307M08Rik; Mpnd", "protein_names_uniprotkb": "MPN domain-containing protein; 3.4.-.-", "protein_names_refseq": "MPN domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68047)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;36834777", "class_list": "", "function": "Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). Binds only double strand DNA (dsDNA) in a sequence-independent manner (PubMed:36834777)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Probable protease. Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation. Binds only double strand DNA (dsDNA) in a sequence-independent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9P5;Q3UIC8;Q8VEN1", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TV65-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZY4-1", "uniprot_id": [ { "id": "MRPP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZY4", "type": "external" } ], "mass": 66857.0, "length": 584, "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "Prorp", "organism": "Mouse", "refseq_name": "mitochondrial ribonuclease P catalytic subunit precursor", "refseq_ac": [ { "id": "NP_079649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079649", "type": "external" } ], "gene_names_uniprotkb": "Prorp; Kiaa0391; Mrpp3", "gene_names_refseq": "1110008L16Rik; Mrpp3; Prorp; mKIAA0391", "protein_names_uniprotkb": "Mitochondrial ribonuclease P catalytic subunit; 3.1.26.5; Mitochondrial RNase P protein 3; Mitochondrial ribonuclease P protein 3", "protein_names_refseq": "mitochondrial RNase P protein 3; mitochondrial ribonuclease P catalytic subunit precursor; mitochondrial ribonuclease P catalytic subunit; mitochondrial ribonuclease P protein 3", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 54 (Disease Ontology:DOID:0070427)", "pathway": " (mmu:66132)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34715011", "class_list": "", "function": "Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A076;Q8BSN8;Q9CTH1;Q9D7W9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004526 ribonuclease P activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0001682 tRNA 5'-leader removal;GO:0097745 mitochondrial tRNA 5'-end processing;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JZY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXX0-1", "uniprot_id": [ { "id": "HYLS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXX0", "type": "external" } ], "mass": 35141.0, "length": 307, "protein_name": "Centriolar and ciliogenesis-associated protein HYLS1", "gene_name": "Hyls1", "organism": "Mouse", "refseq_name": "centriolar and ciliogenesis-associated protein HYLS1", "refseq_ac": [ { "id": "NP_084038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084038", "type": "external" } ], "gene_names_uniprotkb": "Hyls1", "gene_names_refseq": "3010015K02Rik; Hyls1", "protein_names_uniprotkb": "Centriolar and ciliogenesis-associated protein HYLS1; Hydrolethalus syndrome protein 1 homolog", "protein_names_refseq": "centriolar and ciliogenesis-associated protein HYLS1; hydrolethalus syndrome 1; hydrolethalus syndrome protein 1 homolog", "tax_id": 10090, "disease": "hydrolethalus syndrome (Disease Ontology:DOID:0050779); hydrolethalus syndrome 1 (Disease Ontology:DOID:0111355)", "pathway": " (mmu:76832)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15843405;21750661", "class_list": "", "function": "Plays a role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2R4;Q8CI83", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0M9-1", "uniprot_id": [ { "id": "I18BP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0M9", "type": "external" } ], "mass": 21257.0, "length": 193, "protein_name": "Interleukin-18-binding protein", "gene_name": "Il18bp", "organism": "Mouse", "refseq_name": "interleukin-18-binding protein precursor", "refseq_ac": [ { "id": "NP_034661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034661", "type": "external" } ], "gene_names_uniprotkb": "Il18bp; Igifbp", "gene_names_refseq": "IL-18BP; Igifbp; Il18bp; MC54L", "protein_names_uniprotkb": "Interleukin-18-binding protein; IL-18BP; Interferon gamma-inducing factor-binding protein", "protein_names_refseq": "interferon gamma-inducing factor-binding protein; interleukin-18-binding protein precursor", "tax_id": 10090, "disease": "alcoholic liver cirrhosis (Disease Ontology:DOID:14018); cystic fibrosis (Disease Ontology:DOID:1485); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16068); (R-MMU-9012546)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10023777;10094485;10329540;12574381;21750661;32651219;37074208", "class_list": "", "function": "Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%., [RefSeq, PubMed]; Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity)., [UniProtKB]; IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome., [RefSeq, PubMed]; Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJR8;Q4FK87;Q9CV30;Q9QUH2;Q9Z0N0", "ec_number_list": [], "go_molecular_function": "GO:0042007 interleukin-18 binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0140368 decoy receptor complex;GO:0005576 extracellular region", "go_biological_process": "GO:0042088 T-helper 1 type immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0M9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZK9-1", "uniprot_id": [ { "id": "HMCS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZK9", "type": "external" } ], "mass": 57569.0, "length": 520, "protein_name": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic", "gene_name": "Hmgcs1", "organism": "Mouse", "refseq_name": "hydroxymethylglutaryl-CoA synthase, cytoplasmic", "refseq_ac": [ { "id": "NP_001278368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278368", "type": "external" } ], "gene_names_uniprotkb": "Hmgcs1", "gene_names_refseq": "B130032C06Rik; Hmgcs1", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, cytoplasmic", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:208715); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "15345747;17242355;21183079;21750661;24788674;25153642;28135057;28315936;28528544;31219806;32782141;34105348;34203471;34428180;34887587;37507081;38608446", "class_list": "", "function": "Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis., [UniProtKB, UniProtKB]; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA., [UniProtKB, UniProtKB]; Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXI4", "ec_number_list": [ { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" } ], "go_molecular_function": "GO:0043177 organic acid binding;GO:0042803 protein homodimerization activity;GO:0036094 small molecule binding;GO:0016853 isomerase activity;GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0014074 response to purine-containing compound;GO:0006084 acetyl-CoA metabolic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8JZK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VC3-1", "uniprot_id": [ { "id": "IF4A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VC3", "type": "external" } ], "mass": 46840.0, "length": 411, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "Eif4a3", "organism": "Mouse", "refseq_name": "eukaryotic initiation factor 4A-III", "refseq_ac": [ { "id": "NP_619610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619610", "type": "external" } ], "gene_names_uniprotkb": "Eif4a3; Ddx48", "gene_names_refseq": "2400003O03Rik; Ddx48; Eif4a3; eIF4A-III; mKIAA0111", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3; eIF-4A-III; eIF4A-III", "protein_names_refseq": "ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF-4A-III; eukaryotic initiation factor 4A-III", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:192170); (R-MMU-1169408); (R-MMU-159236); (R-MMU-429947); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18480465;21750661;29187734;31219806;34203471;34428180;36210013;37121557;37139782;37586467;39627609", "class_list": "", "function": "ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development., [UniProtKB, UniProtKB]; Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3 and stabilizing MARCKS expression in diabetic cardiomyopathy., [RefSeq, PubMed]; CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression., [RefSeq, PubMed]; The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis., [RefSeq, PubMed]; The knockdown of PRPF19 or EIF4A3 decreased splicing of Lhb, or of both beta subunit transcripts, respectively., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RY38;Q3TEZ8;Q3UD29;Q8BVY3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0043021 ribonucleoprotein complex binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0016071 mRNA metabolic process;GO:1904570 negative regulation of selenocysteine incorporation;GO:0006406 mRNA export from nucleus;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91VC3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921L7-1", "uniprot_id": [ { "id": "HEMK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921L7", "type": "external" } ], "mass": 38233.0, "length": 340, "protein_name": "MTRF1L release factor glutamine methyltransferase", "gene_name": "Hemk1", "organism": "Mouse", "refseq_name": "MTRF1L release factor glutamine methyltransferase", "refseq_ac": [ { "id": "NP_598745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598745", "type": "external" } ], "gene_names_uniprotkb": "Hemk1", "gene_names_refseq": "2310008M14Rik; Hemk1", "protein_names_uniprotkb": "MTRF1L release factor glutamine methyltransferase; 2.1.1.297; HemK methyltransferase family member 1", "protein_names_refseq": "MTRF1L release factor glutamine methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:69536)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZU8", "ec_number_list": [ { "id": "2.1.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.297", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0036009 protein-glutamine N-methyltransferase activity;GO:0102559 peptide chain release factor N(5)-glutamine methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006415 translational termination;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q921L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVS0-1", "uniprot_id": [ { "id": "ICOS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVS0", "type": "external" } ], "mass": 22709.0, "length": 200, "protein_name": "Inducible T-cell costimulator", "gene_name": "Icos", "organism": "Mouse", "refseq_name": "inducible T-cell costimulator precursor", "refseq_ac": [ { "id": "NP_059508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059508", "type": "external" } ], "gene_names_uniprotkb": "Icos; Ailim", "gene_names_refseq": "AILIM; CCLP; CRP-1; H4; Icos; Ly115", "protein_names_uniprotkb": "Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CCLP; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1", "protein_names_refseq": "CD28 and CTLA-4-like protein; CD28-related protein 1; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell costimulator precursor; inducible T-cell costimulator", "tax_id": 10090, "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); colitis (Disease Ontology:DOID:0060180); common variable immunodeficiency 1 (Disease Ontology:DOID:0081144); celiac disease (Disease Ontology:DOID:10608); common variable immunodeficiency (Disease Ontology:DOID:12177); uveitis (Disease Ontology:DOID:13141); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:54167); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9927354)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10617205;10657606;10760791;11006126;11343122;11343123;19915142;21750661;27693916;36210013", "class_list": "", "function": "Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:11343123). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:10657606). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:36754569). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (PubMed:27693916). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:19915142, PubMed:27693916). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (PubMed:11343122)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL17", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0098609 cell-cell adhesion;GO:0002517 T cell tolerance induction;GO:0061470 T follicular helper cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVS0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZL1-1", "uniprot_id": [ { "id": "I17RD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZL1", "type": "external" } ], "mass": 82348.0, "length": 738, "protein_name": "Interleukin-17 receptor D", "gene_name": "Il17rd", "organism": "Mouse", "refseq_name": "interleukin-17 receptor D isoform 1 precursor", "refseq_ac": [ { "id": "NP_602319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_602319", "type": "external" } ], "gene_names_uniprotkb": "Il17rd; Il17rlm; Sef", "gene_names_refseq": "2810004A10Rik; IL-17RD; Il17rd; Sef-S; Sef; mSef", "protein_names_uniprotkb": "Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; Interleukin-17 receptor-like protein; Sef homolog; mSef", "protein_names_refseq": "IL-17 receptor D; interleukin-17 receptor D isoform 1 precursor; interleukin-17 receptor-like protein; sef homolog", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 18 with or without anosmia (Disease Ontology:DOID:0090076)", "pathway": " (mmu:171463); (R-MMU-5674135)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11960706;12604616;12958313;15277532;21750661;23643382;25576668;30084848;38335918", "class_list": "", "function": "Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration., [RefSeq, PubMed]; Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12604616). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis (PubMed:15277532). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (PubMed:12604616). Might have a role in the early stages of fate specification of GnRH-secreting neurons (PubMed:23643382). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Fgf8, Spry2 and Sef belong to a synexpression group and may functionally interact during mouse embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B2RRY7;Q8K447;Q8R5J8", "ec_number_list": [], "go_molecular_function": "GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8JZL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5B8-1", "uniprot_id": [ { "id": "HXC12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K5B8", "type": "external" } ], "mass": 30345.0, "length": 280, "protein_name": "Homeobox protein Hox-C12", "gene_name": "Hoxc12", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C12", "refseq_ac": [ { "id": "NP_034593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034593", "type": "external" } ], "gene_names_uniprotkb": "Hoxc12; Hox-3.8; Hoxc-12", "gene_names_refseq": "Hox-3.8; Hoxc12", "protein_names_uniprotkb": "Homeobox protein Hox-C12; Homeobox protein Hox-3.8", "protein_names_refseq": "Homeobox protein Hox-C12 (Hox-3F); homeo box C12; homeobox protein Hox-3.8; homeobox protein Hox-C12", "tax_id": 10090, "disease": "", "pathway": " (mmu:15421)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11960714;34428180", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K5B8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0V5-1", "uniprot_id": [ { "id": "I23O2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0V5", "type": "external" } ], "mass": 45255.0, "length": 405, "protein_name": "Indoleamine 2,3-dioxygenase 2", "gene_name": "Ido2", "organism": "Mouse", "refseq_name": "indoleamine 2,3-dioxygenase 2", "refseq_ac": [ { "id": "NP_666061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666061", "type": "external" } ], "gene_names_uniprotkb": "Ido2; Indol1", "gene_names_refseq": "C230043N17Rik; Ido-2; Ido2; Indol1", "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 2; 1.13.11.-; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1", "protein_names_refseq": "indoleamine 2,3-dioxygenase 2; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:209176); (R-MMU-71240)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17499941;17671174;18026683;18282734;18364004;21990421;24402311;25477879;25691885;30084848;34428180", "class_list": "", "function": "A second tryptophan catabolic enzyme inducible by IFNg, implicated in transcriptional immune regulation (IFNg-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review) Review article, [RefSeq, PubMed]; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism (PubMed:17499941). Involved in immune regulation (PubMed:25477879)., [UniProtKB, PubMed, PubMed]; Findings implicate novel IDO related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO inhibitor including as an anticancer agent, [RefSeq, PubMed]; IDO-1 and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner., [RefSeq, PubMed]; Role in the inhibition of immune responses to tumours Review article, [RefSeq, PubMed]; This article describes the evolutionary relationships between the INDO and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO and both have the ability to catabolise tryptophan. Erratum:[Gene. 2010 Oct 1;465(1-2):66], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UHF3;E9QKA9", "ec_number_list": [ { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity;GO:0033754 indoleamine 2,3-dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0002376 immune system process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R0V5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC49-1", "uniprot_id": [ { "id": "IF27B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC49", "type": "external" } ], "mass": 27772.0, "length": 283, "protein_name": "Interferon alpha-inducible protein 27-like protein 2B", "gene_name": "Ifi27l2b", "organism": "Mouse", "refseq_name": "interferon alpha-inducible protein 27-like protein 2B precursor", "refseq_ac": [ { "id": "NP_663424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663424", "type": "external" } ], "gene_names_uniprotkb": "Ifi27l2b; Isg12(b2)", "gene_names_refseq": "1810023F06Rik; ISG12(b2); Ifi27l2b", "protein_names_uniprotkb": "Interferon alpha-inducible protein 27-like protein 2B; ISG12(b2); Interferon-stimulated gene 12 protein B2", "protein_names_refseq": "interferon alpha-inducible protein 27-like protein 2B precursor; interferon alpha-inducible protein 27-like protein 2B; interferon stimulated gene 12(b2); interferon-stimulated gene 12 protein B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217845)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14728724;21151029;34428180", "class_list": "", "function": "Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity., [UniProtKB, PubMed]; ISG12b2 is a novel IMM protein induced by IFNs and regulates mitochondria-mediated apoptosis during viral infection, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IEB6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VC49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VF2-1", "uniprot_id": [ { "id": "HNMT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VF2", "type": "external" } ], "mass": 33665.0, "length": 295, "protein_name": "Histamine N-methyltransferase", "gene_name": "Hnmt", "organism": "Mouse", "refseq_name": "histamine N-methyltransferase", "refseq_ac": [ { "id": "NP_536710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536710", "type": "external" } ], "gene_names_uniprotkb": "Hnmt; Hmt", "gene_names_refseq": "1500031F01Rik; Hnmt", "protein_names_uniprotkb": "Histamine N-methyltransferase; 2.1.1.8; HMT", "protein_names_refseq": "HMT; histamine N-methyltransferase", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 51 (Disease Ontology:DOID:0081214); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); brain infarction (Disease Ontology:DOID:3454); essential tremor (Disease Ontology:DOID:4990); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:140483)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11475331;11855681;19162242;29162912;30059200;37507081;38002333", "class_list": "", "function": "Decreasing expression over the time course of the skin pathological changes in MRL/lpr mice Review article, [RefSeq, PubMed]; Genomic structure of the rat and mouse histamine N-methyltransferase gene, [RefSeq, PubMed]; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine., [UniProtKB, PubMed]; KO mice exhibited high aggressive behaviours and exhibited prolonged bouts of awakening during the light (inactive) period and compensatory sleep during the dark (active) period. Publication Status: Online-Only, [RefSeq, PubMed]; Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVH0", "ec_number_list": [ { "id": "2.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0008170 N-methyltransferase activity;GO:0046539 histamine N-methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051384 response to glucocorticoid;GO:0042220 response to cocaine;GO:0070555 response to interleukin-1;GO:0032259 methylation;GO:0035902 response to immobilization stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91VF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J93-1", "uniprot_id": [ { "id": "IFM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J93", "type": "external" } ], "mass": 15743.0, "length": 144, "protein_name": "Interferon-induced transmembrane protein 2", "gene_name": "Ifitm2", "organism": "Mouse", "refseq_name": "interferon-induced transmembrane protein 2", "refseq_ac": [ { "id": "NP_109619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109619", "type": "external" } ], "gene_names_uniprotkb": "Ifitm2", "gene_names_refseq": "DSPA2c; Ifitm2; Ifitm3l; fragilis3; mil-3", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 2; DSPA2c; Dispanin subfamily A member 2c; Fragilis protein 3", "protein_names_refseq": "dispanin subfamily A member 2c; fragilis R; fragilis protein 3; interferon induced transmembrane protein, like; interferon-induced transmembrane protein 2", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": " (mmu:80876); (R-MMU-198933)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12659663;16395393;21166591;21253575;22363774;25428506;30084848;31599954;34428180;37828378", "class_list": "", "function": "IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIG4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99J93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JY6-1", "uniprot_id": [ { "id": "HIG1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JY6", "type": "external" } ], "mass": 10940.0, "length": 98, "protein_name": "HIG1 domain family member 1B", "gene_name": "Higd1b", "organism": "Mouse", "refseq_name": "HIG1 domain family member 1B", "refseq_ac": [ { "id": "NP_543122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543122", "type": "external" } ], "gene_names_uniprotkb": "Higd1b", "gene_names_refseq": "2310056K19Rik; Higd1b", "protein_names_uniprotkb": "HIG1 domain family member 1B", "protein_names_refseq": "HIG1 domain family member 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:75689)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1M5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99JY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQJ1-1", "uniprot_id": [ { "id": "HIG2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQJ1", "type": "external" } ], "mass": 11368.0, "length": 106, "protein_name": "HIG1 domain family member 2A", "gene_name": "Higd2a", "organism": "Mouse", "refseq_name": "HIG1 domain family member 2A", "refseq_ac": [ { "id": "NP_080209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080209", "type": "external" } ], "gene_names_uniprotkb": "Higd2a", "gene_names_refseq": "2010110M21Rik; Higd2a", "protein_names_uniprotkb": "HIG1 domain family member 2A", "protein_names_refseq": "HIG1 domain family member 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67044); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "25605945;30084848;32085461;34428180;35008815;37041638", "class_list": "", "function": "Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology. Publication Status: Online-Only, [RefSeq, PubMed]; Dynamic Distribution of HIG2A between the Mitochondria and the Nucleus in Response to Hypoxia and Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]; HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:1905235 response to quercetin;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQW9-1", "uniprot_id": [ { "id": "IFM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQW9", "type": "external" } ], "mass": 14954.0, "length": 137, "protein_name": "Interferon-induced transmembrane protein 3", "gene_name": "Ifitm3", "organism": "Mouse", "refseq_name": "interferon-induced transmembrane protein 3", "refseq_ac": [ { "id": "NP_079654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079654", "type": "external" } ], "gene_names_uniprotkb": "Ifitm3", "gene_names_refseq": "1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls; IP15; Ifitm3; mil-1", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 3; DSPA2b; Dispanin subfamily A member 2b; Fragilis protein; Interferon-inducible protein 15; Mil-1; Mouse ifitm-like protein 1", "protein_names_refseq": "dispanin subfamily A member 2b; fragilis protein; ifitm-like protein 1; interferon-induced transmembrane protein 3; interferon-inducible protein 15", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": " (mmu:66141); (R-MMU-198933)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "12124616;12659663;14516695;15184081;16326387;16395393;18250455;18505827;19144319;21166591;21253575;22363774;22446628;22467717;22645316;24627473;26495903;28011936;28528544;33270927;34428180;35984892;37828378;39477971", "class_list": "", "function": "Cloning and expression of the mouse gene interferon-inducible-protein 15 (IP15), whose activation is related to the acute phase of experimental pancreatitis [IP15], [RefSeq, PubMed]; IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome. Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Innate immune control of influenza virus interspecies adaptation via IFITM3. Erratum:[Nat Commun. 2024 Dec 11;15(1):10671. doi: 10.1038/s41467-024-54981-w. PMID: 39663387] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8L6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9CQW9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR04-1", "uniprot_id": [ { "id": "HYPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR04", "type": "external" } ], "mass": 13492.0, "length": 117, "protein_name": "Huntingtin-interacting protein M", "gene_name": "H2ap", "organism": "Mouse", "refseq_name": "huntingtin-interacting protein M", "refseq_ac": [ { "id": "NP_080372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080372", "type": "external" } ], "gene_names_uniprotkb": "H2ap; Hypm", "gene_names_refseq": "1700054O13Rik; H2al3; H2ap; Hypm", "protein_names_uniprotkb": "Huntingtin-interacting protein M; Histone H2A.P; Huntingtin yeast partner M", "protein_names_refseq": "histone H2A.P; huntingtin interacting protein M; huntingtin yeast partner M; huntingtin-interacting protein M", "tax_id": 10090, "disease": "", "pathway": " (mmu:67334)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CR04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR41-1", "uniprot_id": [ { "id": "HYPK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR41", "type": "external" } ], "mass": 13651.0, "length": 121, "protein_name": "Huntingtin-interacting protein K", "gene_name": "Hypk", "organism": "Mouse", "refseq_name": "huntingtin-interacting protein K", "refseq_ac": [ { "id": "NP_080594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080594", "type": "external" } ], "gene_names_uniprotkb": "Hypk", "gene_names_refseq": "2310003F16Rik; HSPC136; Hypk", "protein_names_uniprotkb": "Huntingtin-interacting protein K; Huntingtin yeast partner K", "protein_names_refseq": "huntingtin yeast partner K; huntingtin-interacting protein K", "tax_id": 10090, "disease": "", "pathway": " (mmu:67693)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23272104;25446099;27017930", "class_list": "", "function": "Component of several N-terminal acetyltransferase complexes (By similarity). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (By similarity). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (By similarity). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (By similarity)., [UniProtKB, UniProtKB]; HYPK can act as negative regulator of heat shock response by repressing transcriptional activity of HSF1., [RefSeq, PubMed]; HYPK has roles in regulating cell growth, cell cycle, unfolded protein response and cell death, [RefSeq, PubMed]; Specific interaction of HYPK with HTT-N17 is crucial for the chaperone activity of HYPK, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH09;Q8VDK6", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBX7-1", "uniprot_id": [ { "id": "HEYL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBX7", "type": "external" } ], "mass": 34929.0, "length": 326, "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "Heyl", "organism": "Mouse", "refseq_name": "hairy/enhancer-of-split related with YRPW motif-like protein", "refseq_ac": [ { "id": "NP_038933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038933", "type": "external" } ], "gene_names_uniprotkb": "Heyl; Hesr3; Hrt3", "gene_names_refseq": "Hey3; Heyl; Hrt3; bHLHb33; hesr3", "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif-like protein; HRT-3; Hairy and enhancer of split-related protein 3; Hairy-related transcription factor 3; mHRT3", "protein_names_refseq": "HRT-3; hairy and enhance of split related 3; hairy and enhancer of split-related protein 3; hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif-like protein; mHRT3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56198)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10588864;10860664;11044625;11160397;16199874;17303760", "class_list": "", "function": "Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJV6;Q9QXW8", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DBX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUS4-1", "uniprot_id": [ { "id": "HEY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUS4", "type": "external" } ], "mass": 35873.0, "length": 339, "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "Hey2", "organism": "Mouse", "refseq_name": "hairy/enhancer-of-split related with YRPW motif protein 2", "refseq_ac": [ { "id": "NP_038932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038932", "type": "external" } ], "gene_names_uniprotkb": "Hey2; Chf1; Herp1; Herp; Hesr2; Hrt2", "gene_names_refseq": "CHF1; Herp1; Hey2; Hrt2; bHLHb32; hesr2", "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif protein 2; HES-related repressor protein 2; HESR-2; HRT-2; Hairy and enhancer of split-related protein 2; Hairy-related transcription factor 2; Protein gridlock homolog; mHRT2", "protein_names_refseq": "HES-related repressor protein 2; HESR-2; HRT-2; Hairy-E(spl)-related with YRPW motif 2; hairy and enhancer of split related 2; hairy and enhancer of split-related protein 2; hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif protein 2; mHRT2; protein gridlock homolog", "tax_id": 10090, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); aortic valve disease (Disease Ontology:DOID:62); tetralogy of Fallot (Disease Ontology:DOID:6419); varicose veins (Disease Ontology:DOID:799)", "pathway": " (mmu:15214)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10415358;10588864;10692439;10860664;10964718;11095750;11160397;11486044;11486045;11741889;12372253;12372254;12454287;12947105;15107403;15297376;15345511;15485867;15680351;16199874;17259303;17303760;17332425;35820727", "class_list": "", "function": "Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ99;Q8CD44", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0072359 circulatory system development;GO:0003171 atrioventricular valve development;GO:0003208 cardiac ventricle morphogenesis;GO:0003195 tricuspid valve formation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9QUS4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYL0-1", "uniprot_id": [ { "id": "HILS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYL0", "type": "external" } ], "mass": 19203.0, "length": 170, "protein_name": "Histone H1.9", "gene_name": "H1-9", "organism": "Mouse", "refseq_name": "histone H1.9", "refseq_ac": [ { "id": "NP_061262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061262", "type": "external" } ], "gene_names_uniprotkb": "H1-9; H1-9p; H1f9; Hils1", "gene_names_refseq": "H1-9; H1.9; H1f9; Hils1; TISP64", "protein_names_uniprotkb": "Histone H1.9; H1.9 linker histone; Spermatid-specific linker histone H1-like protein; TISP64", "protein_names_refseq": "histone H1-like protein in spermatids 1; histone H1.9; spermatid-specific linker histone H1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:54388)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12920187;14636221;14695911", "class_list": "", "function": "318-base pair (bp) 5'-proximal region, corresponding to first 70-bp proximal TATA-less promoter, and 248 bp of 5'-untranslated region is sufficient to confer testis- and spermatid-specific transcription and posttranscriptional control of mouse hils1 gene., [RefSeq, PubMed]; DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa., [UniProtKB, PubMed, PubMed]; HILS1 is implicated in chromatin remodeling during mammalian spermiogenesis., [RefSeq, PubMed]; Hils1 may play an important role in the structural changes of spermatid nuclei, such as nuclear condensation, and gene regulation of haploid germ cell differentiation., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is expressed in nuclei of late maturing spermatids. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2B1-1", "uniprot_id": [ { "id": "I18RA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2B1", "type": "external" } ], "mass": 70094.0, "length": 614, "protein_name": "Interleukin-18 receptor accessory protein", "gene_name": "Il18rap", "organism": "Mouse", "refseq_name": "interleukin-18 receptor accessory protein precursor", "refseq_ac": [ { "id": "NP_034683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034683", "type": "external" } ], "gene_names_uniprotkb": "Il18rap", "gene_names_refseq": "AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1RAcPL; Il18rap", "protein_names_uniprotkb": "Interleukin-18 receptor accessory protein; 3.2.2.6; AcPL; Accessory protein-like; CD218 antigen-like family member B; IL-18 receptor accessory protein; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R accessory protein-like; IL-1RAcPL; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta", "protein_names_refseq": "AcPL accessory protein-like); CD218 antigen-like family member B; IL-18 receptor accessory protein; accessory protein-like; interleukin-18 receptor accessory protein precursor; interleukin-18 receptor beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:16174); (R-MMU-9012546)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11046021;15843532;21111041;31219806;9792649", "class_list": "", "function": "Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]., [RefSeq]; Our data highlight the considerable complexity of the IL-18 regulation activity in the mouse brain and further support an important central role for IL-18., [RefSeq, PubMed]; This study demonstrates that IL-18 signals are abolished in accessory protein-like (AcPL)-deficient mice and cells, and suggests that AcPL is a critical and specific cell surface receptor required for IL-18 signaling., [RefSeq, PubMed]; Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:11046021, PubMed:15843532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004908 interleukin-1 receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0042008 interleukin-18 receptor activity", "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0071351 cellular response to interleukin-18;GO:0006954 inflammatory response;GO:0008283 cell population proliferation;GO:0070301 cellular response to hydrogen peroxide;GO:0035655 interleukin-18-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2B1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZF8-1", "uniprot_id": [ { "id": "MSL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZF8", "type": "external" } ], "mass": 62538.0, "length": 577, "protein_name": "E3 ubiquitin-protein ligase MSL2", "gene_name": "Msl2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MSL2 isoform 1", "refseq_ac": [ { "id": "NP_001093921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093921", "type": "external" } ], "gene_names_uniprotkb": "Msl2; Kiaa1585; Msl2l1; Rnf184", "gene_names_refseq": "E130103E02Rik; Msl2l1; Msl2; Rnf184", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MSL2; 2.3.2.27; MSL-2; MSL2-like 1; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; Male-specific lethal-2 homolog; RING finger protein 184", "protein_names_refseq": "E3 ubiquitin-protein ligase MSL2 isoform 1; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; MSL2-like 1; male-specific lethal 2 homolog; male-specific lethal 2-like 1; male-specific lethal-2 homolog 1; ring finger protein 184", "tax_id": 10090, "disease": "", "pathway": " (mmu:77853); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19033443;19224205;20173027;21750661;23874665;24842875;25428506;30084848;30779550;34428180;38030723", "class_list": "", "function": "MSL2 ensures biallelic gene expression in mammals., [RefSeq, PubMed]; Msl2 is a novel component of the vertebrate DNA damage response. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:24842875). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (PubMed:38030723). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (PubMed:38030723). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:38030723). This activity is greatly enhanced by heterodimerization with MSL1 (By similarity). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The MSL2-mediated effect on p53 is Mdm2-independent. Thus, our study identifies an important ubiquitin-ligase for modulating p53 subcellular localization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497U7;Q8CBI7", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140585 promoter-enhancer loop anchoring activity;GO:0141054 histone H2B ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0072487 MSL complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0040029 epigenetic regulation of gene expression;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q69ZF8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1C7-1", "uniprot_id": [ { "id": "MOT14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1C7", "type": "external" } ], "mass": 56476.0, "length": 512, "protein_name": "Monocarboxylate transporter 14", "gene_name": "Slc16a14", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 14", "refseq_ac": [ { "id": "NP_082197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082197", "type": "external" } ], "gene_names_uniprotkb": "Slc16a14; Mct14", "gene_names_refseq": "1110004H10Rik; Slc16a14", "protein_names_uniprotkb": "Monocarboxylate transporter 14; MCT 14; Solute carrier family 16 member 14", "protein_names_refseq": "MCT 14; monocarboxylate transporter 14; solute carrier family 16 member 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:71781)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1K0", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K1C7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZC6-1", "uniprot_id": [ { "id": "MRGA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZC6", "type": "external" } ], "mass": 34538.0, "length": 301, "protein_name": "Mas-related G protein-coupled receptor member A6", "gene_name": "Mrgpra6", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A6", "refseq_ac": [ { "id": "NP_001295466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295466", "type": "external" } ], "gene_names_uniprotkb": "Mrgpra6; Mrga6", "gene_names_refseq": "MrgA6; Mrgpra6", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A6", "protein_names_refseq": "MrgA6 G protein-coupled receptor; mas-related G-protein coupled receptor member A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:381886)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11551509;21750661", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMK5;E9QN26", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91ZC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9EJ57-1", "uniprot_id": [ { "id": "MTF1B_MOUSE", "url": "https://www.uniprot.org/uniprot/B9EJ57", "type": "external" } ], "mass": 43761.0, "length": 379, "protein_name": "Transcription termination factor 1b, mitochondrial", "gene_name": "Mterf1b", "organism": "Mouse", "refseq_name": "transcription termination factor 1b, mitochondrial", "refseq_ac": [ { "id": "NP_001036135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036135", "type": "external" } ], "gene_names_uniprotkb": "Mterf1b; Gm9897; Mterf1; Mterf", "gene_names_refseq": "Gm9897; Mterf1b", "protein_names_uniprotkb": "Transcription termination factor 1b, mitochondrial; Mitochondrial transcription termination factor 1b; mTERF1b", "protein_names_refseq": "transcription termination factor 1b, mitochondrial; transcription termination factor, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:208595); (R-MMU-163316)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15582606;21750661;23562081", "class_list": "", "function": "The mouse mTERF is an evolutionarily conserved mitochondrial transcription termination factor and promotes the termination of transcription in mitochondrial RNA., [RefSeq, PubMed]; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "L7N482", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006391 transcription initiation at mitochondrial promoter;GO:0006353 DNA-templated transcription termination;GO:0032392 DNA geometric change", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B9EJ57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YZG8-1", "uniprot_id": [ { "id": "MTD2L_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YZG8", "type": "external" } ], "mass": 36438.0, "length": 338, "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial", "gene_name": "Mthfd2l", "organism": "Mouse", "refseq_name": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial", "refseq_ac": [ { "id": "NP_081064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081064", "type": "external" } ], "gene_names_uniprotkb": "Mthfd2l", "gene_names_refseq": "1110019K23Rik; C630010D07Rik; Mthfd2l", "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein", "protein_names_refseq": "MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:665563); (R-MMU-196757)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;24733394;37828378", "class_list": "", "function": "Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities., [UniProtKB, UniProtKB]; We show here that the MTHFD2L enzyme is bifunctional, possessing both CH2-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.5", "type": "external" }, { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" }, { "id": "1.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.15", "type": "external" }, { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" } ], "go_molecular_function": "GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0006164 purine nucleotide biosynthetic process;GO:0009086 methionine biosynthetic process;GO:0009256 10-formyltetrahydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YZG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1M8-1", "uniprot_id": [ { "id": "MPTX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1M8", "type": "external" } ], "mass": 24538.0, "length": 219, "protein_name": "Mucosal pentraxin", "gene_name": "Mptx1", "organism": "Mouse", "refseq_name": "mucosal pentraxin precursor", "refseq_ac": [ { "id": "NP_079746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079746", "type": "external" } ], "gene_names_uniprotkb": "Mptx1; Mptx", "gene_names_refseq": "1810030J14Rik; Mptx1; Mptx", "protein_names_uniprotkb": "Mucosal pentraxin", "protein_names_refseq": "mucosal pentraxin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18850182;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8J8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0001849 complement component C1q complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1M8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70451-1", "uniprot_id": [ { "id": "MOT2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70451", "type": "external" } ], "mass": 52604.0, "length": 484, "protein_name": "Monocarboxylate transporter 2", "gene_name": "Slc16a7", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 2", "refseq_ac": [ { "id": "NP_035521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035521", "type": "external" } ], "gene_names_uniprotkb": "Slc16a7; Mct2", "gene_names_refseq": "4921534N07Rik; 9030411M13Rik; D630004K10Rik; Mct2; Slc16a7", "protein_names_uniprotkb": "Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7", "protein_names_refseq": "monocarboxylate transporter 2; solute carrier family 16 member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:20503); (R-MMU-433692)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11973431;17496809;21750661;21792931;34428180;36370225;9725820", "class_list": "", "function": "Data provide convincing evidence that MCT2 represents a major neuronal monocarboxylate transporter in the adult mouse brain, [RefSeq, PubMed]; Light-intensity exercise improves memory dysfunction with the restoration of hippocampal MCT2 and miRNAs in type 2 diabetic mice., [RefSeq, PubMed]; Proton-coupled monocarboxylate symporter (PubMed:21792931). Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate. Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015293 symporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:1901475 pyruvate transmembrane transport;GO:0035879 plasma membrane lactate transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70451-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02798-1", "uniprot_id": [ { "id": "MT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P02798", "type": "external" } ], "mass": 6115.0, "length": 61, "protein_name": "Metallothionein-2", "gene_name": "Mt2", "organism": "Mouse", "refseq_name": "metallothionein-2", "refseq_ac": [ { "id": "NP_032656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032656", "type": "external" } ], "gene_names_uniprotkb": "Mt2", "gene_names_refseq": "MT-II; Mt-2; Mt2", "protein_names_uniprotkb": "Metallothionein-2; MT-2; MT-II; Metallothionein-II", "protein_names_refseq": "metallothionein-2; metallothionein-II", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); carotid stenosis (Disease Ontology:DOID:13001); transient cerebral ischemia (Disease Ontology:DOID:224); psychotic disorder (Disease Ontology:DOID:2468); median neuropathy (Disease Ontology:DOID:571); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (mmu:17750); (R-MMU-5661231)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;6095054;7287658", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009617 response to bacterium;GO:0007263 nitric oxide mediated signal transduction;GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02798-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VED8-1", "uniprot_id": [ { "id": "MTFR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VED8", "type": "external" } ], "mass": 40748.0, "length": 361, "protein_name": "Mitochondrial fission regulator 2", "gene_name": "Mtfr2", "organism": "Mouse", "refseq_name": "mitochondrial fission regulator 2", "refseq_ac": [ { "id": "NP_082206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082206", "type": "external" } ], "gene_names_uniprotkb": "Mtfr2; Dufd1; Fam54a", "gene_names_refseq": "2610016C23Rik; 4933412C16Rik; Dufd1; Fam54a; Mtfr2", "protein_names_uniprotkb": "Mitochondrial fission regulator 2; DUF729 domain-containing protein 1", "protein_names_refseq": "DUF729 domain containing 1; DUF729 domain-containing protein 1; family with sequence similarity 54, member A; mitochondrial fission regulator 2; protein FAM54A", "tax_id": 10090, "disease": "", "pathway": " (mmu:71804)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20568109;21750661;37903059", "class_list": "", "function": "Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunctiondagger., [RefSeq, PubMed]; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission., [UniProtKB, PubMed]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB]; The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration and may affect male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PX02", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VED8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2D0-1", "uniprot_id": [ { "id": "MTMR9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2D0", "type": "external" } ], "mass": 62908.0, "length": 545, "protein_name": "Myotubularin-related protein 9", "gene_name": "Mtmr9", "organism": "Mouse", "refseq_name": "myotubularin-related protein 9", "refseq_ac": [ { "id": "NP_808262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808262", "type": "external" } ], "gene_names_uniprotkb": "Mtmr9; Mtmr3", "gene_names_refseq": "9430075G12Rik; LIP-STYX; MTMR8; Mtmr9; mMTMH3", "protein_names_uniprotkb": "Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9", "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 9; myotubularin-related protein 9", "tax_id": 10090, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (mmu:210376); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12890864;21750661;24591580;25605945;34428180;37507081;9736772", "class_list": "", "function": "Acts as an adapter for myotubularin-related phosphatases (PubMed:12890864). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (PubMed:12890864). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (By similarity). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (By similarity). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity)., [UniProtKB, UniProtKB, PubMed]; MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6P1;Q80XL4", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding;GO:0030234 enzyme regulator activity;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0050821 protein stabilization;GO:0010507 negative regulation of autophagy;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z2D0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41245-1", "uniprot_id": [ { "id": "MMP9_MOUSE", "url": "https://www.uniprot.org/uniprot/P41245", "type": "external" } ], "mass": 80535.0, "length": 730, "protein_name": "Matrix metalloproteinase-9", "gene_name": "Mmp9", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-9 preproprotein", "refseq_ac": [ { "id": "NP_038627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038627", "type": "external" } ], "gene_names_uniprotkb": "Mmp9; Clg4b", "gene_names_refseq": "B/MMP9; Clg4b; Gel B; MMP-9; Mmp9; pro-MMP-9", "protein_names_uniprotkb": "Matrix metalloproteinase-9; 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; GELB; Gelatinase B; MMP-9", "protein_names_refseq": "92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; collagenase type IVB; gelatinase B; matrix metalloproteinase-9 preproprotein; matrix metalloproteinase-9", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); sinusitis (Disease Ontology:DOID:0050127); chorioamnionitis (Disease Ontology:DOID:0050697); cardiomyopathy (Disease Ontology:DOID:0050700); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); alcohol-associated liver disease (Disease Ontology:DOID:0070658); meningococcal meningitis (Disease Ontology:DOID:0080176); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); polymyositis (Disease Ontology:DOID:0080745); Sweet syndrome (Disease Ontology:DOID:0080746); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); pigmentation disease (Disease Ontology:DOID:10123); dermatomyositis (Disease Ontology:DOID:10223); stomach cancer (Disease Ontology:DOID:10534); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); arteriovenous malformation (Disease Ontology:DOID:11294); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); retinal ischemia (Disease Ontology:DOID:12510); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); crescentic glomerulonephritis (Disease Ontology:DOID:13139); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); tuberous sclerosis (Disease Ontology:DOID:13515); angle-closure glaucoma (Disease Ontology:DOID:13550); anodontia (Disease Ontology:DOID:13714); familial hypercholesterolemia (Disease Ontology:DOID:13810); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Down syndrome (Disease Ontology:DOID:14250); fragile X syndrome (Disease Ontology:DOID:14261); cystic fibrosis (Disease Ontology:DOID:1485); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); ventricular septal defect (Disease Ontology:DOID:1657); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); Takayasu's arteritis (Disease Ontology:DOID:2508); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); allergic contact dermatitis (Disease Ontology:DOID:3042); glioblastoma (Disease Ontology:DOID:3068); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); conjunctivochalasis (Disease Ontology:DOID:4250); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolysis bullosa simplex (Disease Ontology:DOID:4644); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); chronic inflammatory demyelinating polyradiculoneuropathy (Disease Ontology:DOID:5213); stomach carcinoma (Disease Ontology:DOID:5517); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); viral encephalitis (Disease Ontology:DOID:646); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); varicose veins (Disease Ontology:DOID:799); osteoarthritis (Disease Ontology:DOID:8398); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); chronic ulcer of skin (Disease Ontology:DOID:8549); pyoderma gangrenosum (Disease Ontology:DOID:8553); cholesteatoma (Disease Ontology:DOID:869); bacterial pneumonia (Disease Ontology:DOID:874); neuromyelitis optica (Disease Ontology:DOID:8869); rosacea (Disease Ontology:DOID:8881); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); pulmonary embolism (Disease Ontology:DOID:9477); bronchiectasis (Disease Ontology:DOID:9563); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17395); (R-MMU-1433557); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-2022090); (R-MMU-3928665); (R-MMU-6798695); (R-MMU-9009391)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "11500442;12542794;19893577;21750661;23142597;32883094;39627609;8132709;8219207;8243459;8382489", "class_list": "", "function": "Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (PubMed:8132709). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:23142597, PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 9, "predicted_n_glycosites": 3, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 136, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q06788;Q80XI8;Q9DC02", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.21.117", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.117", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0007507 heart development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41245-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJG4-1", "uniprot_id": [ { "id": "MOB3C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJG4", "type": "external" } ], "mass": 25521.0, "length": 216, "protein_name": "MOB kinase activator 3C", "gene_name": "Mob3c", "organism": "Mouse", "refseq_name": "MOB kinase activator 3C", "refseq_ac": [ { "id": "NP_780517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780517", "type": "external" } ], "gene_names_uniprotkb": "Mob3c; Mobkl2c", "gene_names_refseq": "D130076I06Rik; Mob3c; Mobkl2c", "protein_names_uniprotkb": "MOB kinase activator 3C; Mob1 homolog 2C; Mps one binder kinase activator-like 2C", "protein_names_refseq": "MOB kinase activator 3C; MOB1, Mps One Binder kinase activator-like 2C; mob1 homolog 2C", "tax_id": 10090, "disease": "", "pathway": " (mmu:100465)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30084848;31219806;34428180", "class_list": "", "function": "May regulate the activity of kinases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFI6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70236-1", "uniprot_id": [ { "id": "MP2K6_MOUSE", "url": "https://www.uniprot.org/uniprot/P70236", "type": "external" } ], "mass": 37432.0, "length": 334, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6", "gene_name": "Map2k6", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 6 isoform 1", "refseq_ac": [ { "id": "NP_036073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036073", "type": "external" } ], "gene_names_uniprotkb": "Map2k6; Prkmk6; Sapkk3", "gene_names_refseq": "MAPKK 6; MAPKK6; MEK6; MKK6; Map2k6; Prkmk6; SAPKK3", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 6; 2.7.12.2; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MEK 6; SAPKK3", "protein_names_refseq": "MAP kinase kinase 6; MAPK/ERK kinase 6; dual specificity mitogen-activated protein kinase kinase 6 isoform 1; dual specificity mitogen-activated protein kinase kinase 6; protein kinase, mitogen activated, kinase 6", "tax_id": 10090, "disease": "Pick's disease (Disease Ontology:DOID:11870); Parkinson's disease (Disease Ontology:DOID:14330); restrictive cardiomyopathy (Disease Ontology:DOID:397); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); progressive supranuclear palsy (Disease Ontology:DOID:678); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:26399); (R-MMU-168638); (R-MMU-2559580); (R-MMU-450302); (R-MMU-6811555); (R-MMU-9020702); (R-MMU-9833482)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "12151339;12482988;12824301;12893778;15644321;16387856;16498455;20004242;21750661;26495903;34948353;35971771;39927985;8861944;9779990", "class_list": "", "function": "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity. Publication Status: Online-Only, [RefSeq, PubMed]; MKK6 deficiency promotes cardiac dysfunction through MKK3-p38gamma/delta-mTOR hyperactivation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:1904784 NLRP1 inflammasome complex assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P70236-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6Z1-1", "uniprot_id": [ { "id": "MUC15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6Z1", "type": "external" } ], "mass": 36383.0, "length": 331, "protein_name": "Mucin-15", "gene_name": "Muc15", "organism": "Mouse", "refseq_name": "mucin-15 isoform b precursor", "refseq_ac": [ { "id": "NP_001277715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277715", "type": "external" } ], "gene_names_uniprotkb": "Muc15", "gene_names_refseq": "4732460E09; D730046L02Rik; MUC-15; Muc15", "protein_names_uniprotkb": "Mucin-15; MUC-15", "protein_names_refseq": "mucin-15 isoform b precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:269328); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQC4;Q6XYQ9;Q7TMH6;Q8CE82", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C6Z1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H5Y1-1", "uniprot_id": [ { "id": "MPP9_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H5Y1", "type": "external" } ], "mass": 123259.0, "length": 1114, "protein_name": "M-phase phosphoprotein 9", "gene_name": "Mphosph9", "organism": "Mouse", "refseq_name": "M-phase phosphoprotein 9 isoform b", "refseq_ac": [ { "id": "NP_001074792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074792", "type": "external" } ], "gene_names_uniprotkb": "Mphosph9", "gene_names_refseq": "4930548D04Rik; 9630025B04Rik; B930097C17Rik; MPP-9; MPP9; Mphosph9", "protein_names_uniprotkb": "M-phase phosphoprotein 9", "protein_names_refseq": "M-phase phosphoprotein 9 isoform b", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:269702)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30375385", "class_list": "", "function": "MPP9 acts as a regulator of ciliogenesis by regulating the localization of CP110-CEP97 at the mother centriole. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8Q0P9S6;E9QPF8;Q8BUK7;Q8BV15;V9GX48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902018 negative regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6H5Y1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AWI6-1", "uniprot_id": [ { "id": "MSMP_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AWI6", "type": "external" } ], "mass": 14981.0, "length": 139, "protein_name": "Prostate-associated microseminoprotein", "gene_name": "Msmp", "organism": "Mouse", "refseq_name": "prostate-associated microseminoprotein precursor", "refseq_ac": [ { "id": "NP_001092784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092784", "type": "external" } ], "gene_names_uniprotkb": "Msmp; Psmp", "gene_names_refseq": "Msmp; Psmp", "protein_names_uniprotkb": "Prostate-associated microseminoprotein; PC3-secreted microprotein homolog", "protein_names_refseq": "PC3-secreted microprotein homolog; Vmicroseminoprotein, prostate associated; prostate-associated microseminoprotein precursor; prostate-associated microseminoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039672)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "28698550;29059175;31219806;31813573;38796708", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (By similarity)., [UniProtKB, UniProtKB]; High MSMP expression is associated with drug-resistant prostate cancer., [RefSeq, PubMed]; PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target., [RefSeq, PubMed]; Study shows that PSMP plays a vital role in promoting dextran sodium sulfate (DSS)-colitis. PSMP is significantly up-regulated DSS-induced mouse colitis. PSMP is up-regulated in the initial stage prior to IL-6, TNF-alpha and CCL2 up-regulated expression in DSS colitis and promote the M1 macrophages to produce CCL2. PMSP affects the monocytes and macrophages through CCR2. Publication Status: Online-Only, [RefSeq, PubMed]; The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0048247 lymphocyte chemotaxis;GO:0002548 monocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B1AWI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RX12-1", "uniprot_id": [ { "id": "MRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RX12", "type": "external" } ], "mass": 169223.0, "length": 1523, "protein_name": "ATP-binding cassette sub-family C member 3", "gene_name": "Abcc3", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 3 isoform 2", "refseq_ac": [ { "id": "NP_083876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083876", "type": "external" } ], "gene_names_uniprotkb": "Abcc3; Cmoat2; Mrp3", "gene_names_refseq": "1700019L09Rik; ABC31; Abcc3; MLP2; MOAT-D; MRP3", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 3; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multispecific organic anion transporter 2; Multidrug resistance-associated protein 3", "protein_names_refseq": "ATP-binding cassette protein C3; ATP-binding cassette sub-family C member 3 isoform 2; ATP-binding cassette transporter; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; multidrug resistance-associated protein 3", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); bilirubin metabolic disorder (Disease Ontology:DOID:2741); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); acute myeloid leukemia (Disease Ontology:DOID:9119); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:76408); (R-MMU-159418); (R-MMU-382556); (R-MMU-9749641); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "12837754;15814571;15824121;16225954;17242355;21750661;27525577;34203471;34428180;35820727", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (PubMed:15814571, PubMed:16225954). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Abbcc3 knock-out mice have enhanced platelet response to clopidogrel due to increased formation of clopidogral active metabolite., [RefSeq, PubMed]; Induction of Mrp3 plays a significant role in hepatocyte protection during obstructive cholestasis, [RefSeq, PubMed]; VDR has a role in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "J3QML2;Q3U1W8;Q56PH0;Q59DK9;Q59DL0;Q5SUF4;Q80ZK8", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015432 ABC-type bile acid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0036064 ciliary basal body;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0015722 canalicular bile acid transport;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B2RX12-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z1Q2-1", "uniprot_id": [ { "id": "MRAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z1Q2", "type": "external" } ], "mass": 23678.0, "length": 207, "protein_name": "Melanocortin-2 receptor accessory protein 2", "gene_name": "Mrap2", "organism": "Mouse", "refseq_name": "melanocortin-2 receptor accessory protein 2", "refseq_ac": [ { "id": "NP_001094952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094952", "type": "external" } ], "gene_names_uniprotkb": "Mrap2", "gene_names_refseq": "Mrap2", "protein_names_uniprotkb": "Melanocortin-2 receptor accessory protein 2", "protein_names_refseq": "melanocortin-2 receptor accessory protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244958)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20371771;22366472;23869016;26829592;27106110;28959025;34759891;36077245", "class_list": "", "function": "Arginine 125 Is an Essential Residue for the Function of MRAP2. Publication Status: Online-Only, [RefSeq, PubMed]; Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer. Publication Status: Online-Only, [RefSeq, PubMed]; MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus. Publication Status: Online-Only, [RefSeq, PubMed]; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo., [UniProtKB, PubMed, PubMed]; Mrap2 KO mice have a significant increase in body weight, with increased fat and lean mass, but without detectable changes in food intake or energy expenditure. Transcriptomic analysis showed significantly decreased expression of Sim1, Trh, Oxt and Crh within the paraventricular nucleus of Mrap2 KO mice. Circulating levels of both high-density and low-density lipoprotein were increased in Mrap2 KO mice., [RefSeq, PubMed]; Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. Erratum:[Science. 2013 Aug 30;341(6149):959], [RefSeq, PubMed]; Show that MRAP2 significantly and specifically inhibits PKR1 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YVA7;D3YZ75;D3Z746", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding;GO:0031780 corticotropin hormone receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0097009 energy homeostasis;GO:0007631 feeding behavior;GO:0006112 energy reserve metabolic process;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "D3Z1Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUE7-1", "uniprot_id": [ { "id": "MUC20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUE7", "type": "external" } ], "mass": 68720.0, "length": 656, "protein_name": "Mucin-20", "gene_name": "Muc20", "organism": "Mouse", "refseq_name": "mucin-20 isoform a precursor", "refseq_ac": [ { "id": "NP_001139346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139346", "type": "external" } ], "gene_names_uniprotkb": "Muc20", "gene_names_refseq": "Muc20", "protein_names_uniprotkb": "Mucin-20; MUC-20", "protein_names_refseq": "MUC-20; mucin-20 isoform a precursor", "tax_id": 10090, "disease": "IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:224116); (R-MMU-8851805); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "14565953;15314156;21750661", "class_list": "", "function": "May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity)., [UniProtKB]; Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q76I84;Q8R0X0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0048012 hepatocyte growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BUE7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924M7-1", "uniprot_id": [ { "id": "MPI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924M7", "type": "external" } ], "mass": 46575.0, "length": 423, "protein_name": "Mannose-6-phosphate isomerase", "gene_name": "Mpi", "organism": "Mouse", "refseq_name": "mannose-6-phosphate isomerase", "refseq_ac": [ { "id": "NP_080113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080113", "type": "external" } ], "gene_names_uniprotkb": "Mpi; Mpi1; Pmi", "gene_names_refseq": "1110002E17Rik; Mpi-1; Mpi1; Mpi", "protein_names_uniprotkb": "Mannose-6-phosphate isomerase; 5.3.1.8; PMI; Phosphohexomutase; Phosphomannose isomerase", "protein_names_refseq": "PMI; mannose phosphate isomerase 1; mannose-6-phosphate isomerase; phosphohexomutase; phosphomannose isomerase", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ib (Disease Ontology:DOID:0080554); carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (mmu:110119); (R-MMU-446205)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12122025;21750661;22872234;24421398;25428506;30084848;37507081;38459021;39927985", "class_list": "glycogene", "function": "Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice., [RefSeq, PubMed]; Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions., [UniProtKB, PubMed]; PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.8", "type": "external" } ], "go_molecular_function": "GO:0004476 mannose-6-phosphate isomerase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0061611 mannose to fructose-6-phosphate catabolic process;GO:0009298 GDP-mannose biosynthetic process;GO:0061619 glycolytic process from mannose through fructose-6-phosphate;GO:0061729 GDP-D-mannose biosynthetic process from fructose-6-phosphate", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q924M7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1X5-1", "uniprot_id": [ { "id": "MRP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1X5", "type": "external" } ], "mass": 161125.0, "length": 1436, "protein_name": "ATP-binding cassette sub-family C member 5", "gene_name": "Abcc5", "organism": "Mouse", "refseq_name": "ATP-binding cassette sub-family C member 5 isoform 1", "refseq_ac": [ { "id": "NP_038818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038818", "type": "external" } ], "gene_names_uniprotkb": "Abcc5; Abcc5a; Mrp5", "gene_names_refseq": "2900011L11Rik; Abcc5a; Abcc5b; Abcc5; Mrp5", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 5; 7.6.2.-; 7.6.2.2; MOAT-C; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; SMRP", "protein_names_refseq": "ATP-binding cassette sub-family C member 5 isoform 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; MOAT-C; SMRP; multi-specific organic anion transporter C; multidrug resistance-associated protein 5", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:27416); (R-MMU-2142845); (R-MMU-382556); (R-MMU-9748787); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10721709;16361063;17229149;19144319;21183079;21750661;24836561;25428506;25605945;26515061;27802388;30059200;30084848;30779550;31219806;31338999;31599954;34428180;35121660;35820727;36210013;37828378", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites like cyclic nucleotides, such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (By similarity) (PubMed:17229149). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (By similarity). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity (By similarity). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (PubMed:31338999)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function., [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "O88284;Q5CZY2", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015232 heme transmembrane transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015865 purine nucleotide transport;GO:0098838 folate transmembrane transport;GO:0030213 hyaluronan biosynthetic process;GO:0034775 glutathione transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9R1X5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WW5-1", "uniprot_id": [ { "id": "MRGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WW5", "type": "external" } ], "mass": 34381.0, "length": 304, "protein_name": "Mas-related G protein-coupled receptor member A1", "gene_name": "Mrgpra1", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A1", "refseq_ac": [ { "id": "NP_694735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694735", "type": "external" } ], "gene_names_uniprotkb": "Mrgpra1; Mrga1", "gene_names_refseq": "MrgA1; Mrgpra1", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A1; RF-amide G protein-coupled receptor", "protein_names_refseq": "RF-amide G protein-coupled receptor; mas-related G-protein coupled receptor member A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233221)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11551509;12397184;21750661;28219706;30657454;31068464", "class_list": "", "function": "G protein-coupled receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide (PubMed:12397184). Also acts as a receptor for substance P, a basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:28219706). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:12397184). Mrgpra1 is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca2+ ions from intracellular stores, respectively (PubMed:12397184). May regulate the function of nociceptive neurons by modulation of pain perception (PubMed:12397184). Does not act as a receptor for bile acids (PubMed:31068464). May be involved in itch perception following activatuion by substance P (PubMed:28219706, PubMed:30657454)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Is activated by RF-amide-related peptides through the Galpha q/11 pathway, [RefSeq, PubMed]; We deduce that substance P activates MrgprA1 on sensory neurons rather than NK-1R to induce itch, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JNS0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005525 GTP binding;GO:0008188 neuropeptide receptor activity;GO:0038182 G protein-coupled bile acid receptor activity;GO:0031409 pigment binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:1905237 response to cyclosporin A;GO:1901652 response to peptide;GO:0160025 sensory perception of itch", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WW3-1", "uniprot_id": [ { "id": "MRGA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WW3", "type": "external" } ], "mass": 34483.0, "length": 302, "protein_name": "Mas-related G protein-coupled receptor member A3", "gene_name": "Mrgpra3", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A3", "refseq_ac": [ { "id": "NP_694707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694707", "type": "external" } ], "gene_names_uniprotkb": "Mrgpra3; Mrga3", "gene_names_refseq": "Mrga3; Mrgpra3", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A3", "protein_names_refseq": "G protein-coupled receptor MRGA3; Mas-related gene A3; mas-related G-protein coupled receptor member A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:233222)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11551509;20004959;21750661;29064954;32234460;33727332", "class_list": "", "function": "Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension., [RefSeq, PubMed]; Molecular Signature of Pruriceptive MrgprA3(+) Neurons., [RefSeq, PubMed]; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Activated by the antimalarial drug chloroquine. Mediates chloroquine-induced itch, in a histamine-independent manner., [UniProtKB, PubMed]; Results showed that the scratching bouts induced by chloroquine increased significantly under the acetone-ether-water (AEW) chronic pruritus; the density of MrgprA3 sensory fibers in the AEW-treated skin area and the number of MrgprA3 neurons in dorsal root ganglia from the AEW model mice also increased significantly. Further analysis showed that the MrgprA3 in mRNA level was also increased after AEW treatment., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0006953 acute-phase response;GO:0007635 chemosensory behavior;GO:1902349 response to chloroquine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES57-1", "uniprot_id": [ { "id": "MO2R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES57", "type": "external" } ], "mass": 35505.0, "length": 326, "protein_name": "Cell surface glycoprotein CD200 receptor 1", "gene_name": "Cd200r1", "organism": "Mouse", "refseq_name": "cell surface glycoprotein CD200 receptor 1 precursor", "refseq_ac": [ { "id": "NP_067300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067300", "type": "external" } ], "gene_names_uniprotkb": "Cd200r1; Mox2r; Ox2r", "gene_names_refseq": "CD200R; Cd200r1; Mox2r; OX2R", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1", "protein_names_refseq": "CD200 cell surface glycoprotein receptor; Orexin receptor 2; antigen identified by monoclonal antibody MRC OX-2 receptor; cell surface glycoprotein CD200 receptor 1 precursor; cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57781)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10981966;12960329;15187158;15274657;15471863;19144319;21750661;23602662;24388216;30195773;36623588;37902837;37903272;39294682", "class_list": "", "function": "Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice., [RefSeq, PubMed]; CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation., [RefSeq, PubMed]; Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy., [RefSeq, PubMed]; Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli., [UniProtKB, PubMed, PubMed]; The CD200 receptor gene family resembles the signal regulatory proteins and killer Ig-related receptors in having receptor family members with potential activatory and inhibitory functions that may play important roles in immune regulation and balance., [RefSeq, PubMed]; The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1905522 negative regulation of macrophage migration;GO:0032715 negative regulation of interleukin-6 production;GO:2000405 negative regulation of T cell migration;GO:0034113 heterotypic cell-cell adhesion;GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9ES57-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08540-1", "uniprot_id": [ { "id": "MSMB_MOUSE", "url": "https://www.uniprot.org/uniprot/O08540", "type": "external" } ], "mass": 12845.0, "length": 113, "protein_name": "Beta-microseminoprotein", "gene_name": "Msmb", "organism": "Mouse", "refseq_name": "beta-microseminoprotein precursor", "refseq_ac": [ { "id": "NP_065622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065622", "type": "external" } ], "gene_names_uniprotkb": "Msmb; Psp94", "gene_names_refseq": "Msmb; PIP; PSP94; beta-MSP", "protein_names_uniprotkb": "Beta-microseminoprotein; PSP-94; PSP94; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids", "protein_names_refseq": "PSP-94; beta-inhibin; beta-microseminoprotein precursor; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids; prostatic inhibin protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:17695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12616537", "class_list": "", "function": "Establishment and characterization of PSP94 antibodies contribute to the potential for PSP94 as a new vector gene for prostate cancer gene therapy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O08540-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08601-1", "uniprot_id": [ { "id": "MTP_MOUSE", "url": "https://www.uniprot.org/uniprot/O08601", "type": "external" } ], "mass": 99099.0, "length": 894, "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "Mttp", "organism": "Mouse", "refseq_name": "microsomal triglyceride transfer protein large subunit isoform 1 precursor", "refseq_ac": [ { "id": "NP_001156929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156929", "type": "external" } ], "gene_names_uniprotkb": "Mttp; Mtp", "gene_names_refseq": "1810043K16Rik; MTP; Mttp", "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit", "protein_names_refseq": "microsomal triglyceride transfer protein B; microsomal triglyceride transfer protein large subunit isoform 1 precursor; microsomal triglyceride transfer protein, large subunit", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); familial hypercholesterolemia (Disease Ontology:DOID:13810); abetalipoproteinemia (Disease Ontology:DOID:1386); hyperinsulinism (Disease Ontology:DOID:2018); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17777); (R-MMU-8866423); (R-MMU-8963888); (R-MMU-8964041)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10713055;10744773;15897609;16478722;17312007;17635917;18497885;18502767;24353284;25428506;28011936;30084848;33168624;37453647;38211723;38445789;8660984;9502759", "class_list": "", "function": "Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:18502767, PubMed:33168624). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:10713055, PubMed:17635917, PubMed:18502767, PubMed:33168624, PubMed:9502759). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (PubMed:18502767)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion., [RefSeq, PubMed]; Critical for the development of natural killer T (NKT) cells (PubMed:17312007). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17635917)., [UniProtKB, PubMed, PubMed]; Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2CXA7;Q3UJA0;Q91X33", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0034185 apolipoprotein binding;GO:0046982 protein heterodimerization activity;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006641 triglyceride metabolic process;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O08601-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08789-1", "uniprot_id": [ { "id": "MNT_MOUSE", "url": "https://www.uniprot.org/uniprot/O08789", "type": "external" } ], "mass": 63274.0, "length": 591, "protein_name": "Max-binding protein MNT", "gene_name": "Mnt", "organism": "Mouse", "refseq_name": "max-binding protein MNT", "refseq_ac": [ { "id": "NP_034943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034943", "type": "external" } ], "gene_names_uniprotkb": "Mnt; Rox", "gene_names_refseq": "Mnt; Rox; bHLHd3", "protein_names_uniprotkb": "Max-binding protein MNT; Myc antagonist MNT; Protein ROX", "protein_names_refseq": "max-binding protein MNT; myc antagonist MNT", "tax_id": 10090, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469)", "pathway": " (mmu:17428)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;23150551;25428506;28800127;30084848;34428180;34678516;36755068;36852467;9000049;9184233", "class_list": "", "function": "Although mnt heterozygosity clearly slowed lymphomagenesis in vavP-MYC10 and Emu-myc mice, the change(s) in cellular properties responsible for this effect remain to be identified., [RefSeq, PubMed]; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'., [UniProtKB, UniProtKB, UniProtKB]; MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis., [RefSeq, PubMed]; Results redefine the physiological relationship between Mnt and Myc and requirements for Myc-driven oncogenesis, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "P97349;Q6GTJ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070443 Mad-Max complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0090398 cellular senescence", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O08789-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88676-1", "uniprot_id": [ { "id": "MMP23_MOUSE", "url": "https://www.uniprot.org/uniprot/O88676", "type": "external" } ], "mass": 44451.0, "length": 391, "protein_name": "Matrix metalloproteinase-23", "gene_name": "Mmp23", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-23 isoform 2", "refseq_ac": [ { "id": "NP_001307164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307164", "type": "external" } ], "gene_names_uniprotkb": "Mmp23; Cammp", "gene_names_refseq": "CA-MMP; Mmp23", "protein_names_uniprotkb": "Matrix metalloproteinase-23; 3.4.24.-; CA-MMP; CAMP metalloproteinase; Cysteine array matrix metalloproteinase; MMP-23", "protein_names_refseq": "CAMP metalloproteinase; cysteine array matrix metalloproteinase; matrix metalloproteinase-23 isoform 2; matrix metalloproteinase-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:26561)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10471791;34428180", "class_list": "", "function": "Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein contains an N-terminal cysteine array and a novel immunoglobulin-fold domain at the C-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNC0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88676-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28862-1", "uniprot_id": [ { "id": "MMP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P28862", "type": "external" } ], "mass": 53845.0, "length": 477, "protein_name": "Stromelysin-1", "gene_name": "Mmp3", "organism": "Mouse", "refseq_name": "stromelysin-1 preproprotein", "refseq_ac": [ { "id": "NP_034939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034939", "type": "external" } ], "gene_names_uniprotkb": "Mmp3", "gene_names_refseq": "EMS-2; MMP-3; Mmp3; SL-1; SLN-1; SLN1; STR-1; Stmy1; Str1", "protein_names_uniprotkb": "Stromelysin-1; 3.4.24.17; EMS-2; MMP-3; Matrix metalloproteinase-3; SL-1; Transin-1", "protein_names_refseq": "matrix metalloproteinase 3; progelatinase; stromelysin-1 preproprotein; stromelysin-1; transin-1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); Parkinsonism (Disease Ontology:DOID:0080855); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); gastric ulcer (Disease Ontology:DOID:10808); Alport syndrome (Disease Ontology:DOID:10983); cartilage disease (Disease Ontology:DOID:1222); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); Takayasu's arteritis (Disease Ontology:DOID:2508); glomerulonephritis (Disease Ontology:DOID:2921); allergic contact dermatitis (Disease Ontology:DOID:3042); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); polymyalgia rheumatica (Disease Ontology:DOID:853); degenerative disc disease (Disease Ontology:DOID:90); psoriatic arthritis (Disease Ontology:DOID:9008); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:17392); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-2022090); (R-MMU-2179392); (R-MMU-9009391)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "1398148;17116747;25428506;2744464;35940311;39000490;39030581;41018975", "class_list": "", "function": "MMP-3 Knockout Induces Global Transcriptional Changes and Reduces Cerebral Infarction in Both Male and Female Models of Ischemic Stroke. Publication Status: Online-Only, [RefSeq, PubMed]; MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:17116747). In addition, plays a role in immune response and possesses antiviral activity against various viruses (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration;GO:0045087 innate immune response;GO:0031334 positive regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P28862-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57748-1", "uniprot_id": [ { "id": "MMP20_MOUSE", "url": "https://www.uniprot.org/uniprot/P57748", "type": "external" } ], "mass": 54373.0, "length": 482, "protein_name": "Matrix metalloproteinase-20", "gene_name": "Mmp20", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-20 preproprotein", "refseq_ac": [ { "id": "NP_038931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038931", "type": "external" } ], "gene_names_uniprotkb": "Mmp20", "gene_names_refseq": "Mmp20", "protein_names_uniprotkb": "Matrix metalloproteinase-20; 3.4.24.-; Enamel metalloproteinase; Enamelysin; MMP-20", "protein_names_refseq": "enamel metalloproteinase; matrix metalloproteinase 20 (enamelysin); matrix metalloproteinase-20 preproprotein; matrix metalloproteinase-20", "tax_id": 10090, "disease": "amelogenesis imperfecta hypomaturation type 2A2 (Disease Ontology:DOID:0110060)", "pathway": " (mmu:30800); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-2022090)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10610728;12206593;21285247;25428506;34012043;37914726", "class_list": "", "function": "Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site., [UniProtKB, UniProtKB]; Expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins, [RefSeq, PubMed]; MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations. Publication Status: Online-Only, [RefSeq, PubMed]; Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblasts, and the encoded protein is an inactive zymogen that requires proteolytic removal of a N-terminal propeptide to become enzymatically active. Mice lacking the encoded protein display an amelogenesis imperfecta phenotype. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7MCV5", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0030163 protein catabolic process;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P57748-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01727-1", "uniprot_id": [ { "id": "MSHR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01727", "type": "external" } ], "mass": 35226.0, "length": 315, "protein_name": "Melanocyte-stimulating hormone receptor", "gene_name": "Mc1r", "organism": "Mouse", "refseq_name": "melanocyte-stimulating hormone receptor", "refseq_ac": [ { "id": "NP_032585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032585", "type": "external" } ], "gene_names_uniprotkb": "Mc1r; Msh-r", "gene_names_refseq": "Mc1r; Mcr1; Mshra; Tob; e", "protein_names_uniprotkb": "Melanocyte-stimulating hormone receptor; MC1-R; MSH-R; Melanocortin receptor 1", "protein_names_refseq": "MC1-R; MSH-R; extension recessive yellow; melanocortin receptor 1; melanocyte-stimulating hormone receptor; tobacco darkening", "tax_id": 10090, "disease": "oculocutaneous albinism type II (Disease Ontology:DOID:0070096); pigmentation disease (Disease Ontology:DOID:10123); major depressive disorder (Disease Ontology:DOID:1470); melanoma (Disease Ontology:DOID:1909); familial melanoma (Disease Ontology:DOID:6846)", "pathway": " (mmu:17199); (R-MMU-375276); (R-MMU-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1325670;15653560;38110615;38433184;39117851;7935841", "class_list": "", "function": "G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed:1325670). Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis (By similarity). Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby downregulating melanogenesis (PubMed:7935841). Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy., [RefSeq, PubMed]; LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion. Publication Status: Online-Only, [RefSeq, PubMed]; Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q75NA3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0042562 hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019233 sensory perception of pain;GO:0032720 negative regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q01727-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCE8-1", "uniprot_id": [ { "id": "MRS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCE8", "type": "external" } ], "mass": 49299.0, "length": 434, "protein_name": "Magnesium transporter MRS2 homolog, mitochondrial", "gene_name": "Mrs2", "organism": "Mouse", "refseq_name": "magnesium transporter MRS2 homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001013407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013407", "type": "external" } ], "gene_names_uniprotkb": "Mrs2; Gm902; Mrs2l", "gene_names_refseq": "Gm902; HPT; Mrs2l; Mrs2; RPT", "protein_names_uniprotkb": "Magnesium transporter MRS2 homolog, mitochondrial; MRS2-like protein", "protein_names_refseq": "MRS2 magnesium homeostasis factor homolog; magnesium transporter MRS2 homolog, mitochondrial precursor; magnesium transporter MRS2 homolog, mitochondrial", "tax_id": 10090, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (mmu:380836); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11401429;30084848;30779550;33300544;34428180;36857182;38878275", "class_list": "", "function": "Limiting Mrs2-dependent mitochondrial Mg[2+] uptake induces metabolic programming in prolonged dietary stress., [RefSeq, PubMed]; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism (By similarity). Also permeable to calcium, sodium and potassium ions (By similarity). Required for normal expression of the mitochondrial respiratory complex I subunits (By similarity). May play a role in maintaining the inner mitochondrial membrane potential (By similarity)., [UniProtKB, UniProtKB]; Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006089 lactate metabolic process;GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5NCE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ND52-1", "uniprot_id": [ { "id": "MRM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5ND52", "type": "external" } ], "mass": 46796.0, "length": 418, "protein_name": "rRNA methyltransferase 3, mitochondrial", "gene_name": "Mrm3", "organism": "Mouse", "refseq_name": "rRNA methyltransferase 3, mitochondrial", "refseq_ac": [ { "id": "NP_899086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899086", "type": "external" } ], "gene_names_uniprotkb": "Mrm3; Rnmtl1", "gene_names_refseq": "4833420N02Rik; HC90; Mrm3; Rnmtl1", "protein_names_uniprotkb": "rRNA methyltransferase 3, mitochondrial; 16S rRNA (guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; 2.1.1.-; RNA methyltransferase-like protein 1", "protein_names_refseq": "16S rRNA (guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; RNA methyltransferase like 1; RNA methyltransferase-like protein 1; rRNA methyltransferase 3, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:67390)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24036117;35820727", "class_list": "", "function": "RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1369 (Um1369) mediated by MRM2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUR4;Q3UGQ7;Q5U5W2;Q8C1J9", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ND52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZX6-1", "uniprot_id": [ { "id": "MOR2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZX6", "type": "external" } ], "mass": 117330.0, "length": 1030, "protein_name": "ATPase MORC2A", "gene_name": "Morc2a", "organism": "Mouse", "refseq_name": "ATPase MORC2A isoform 1", "refseq_ac": [ { "id": "NP_001152760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152760", "type": "external" } ], "gene_names_uniprotkb": "Morc2a; Kiaa0852; Zcwcc1", "gene_names_refseq": "8430403M08Rik; Morc2a; Zcwcc1", "protein_names_uniprotkb": "ATPase MORC2A; 3.6.1.-; MORC family CW-type zinc finger protein 2A; Zinc finger CW-type coiled-coil domain protein 1", "protein_names_refseq": "ATPase MORC2A isoform 1; ATPase MORC2A; MORC family CW-type zinc finger protein 2A; zinc finger CW-type coiled-coil domain protein 1; zinc finger, CW-type with coiled-coil domain 1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2Z (Disease Ontology:DOID:0110181)", "pathway": " (mmu:74522); (R-MMU-75105)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;19131326;21183079;21750661;26497905;29329290;29728365;36332029;38227798;40885482;41018975", "class_list": "", "function": "ATP-dependent chromatin remodeler essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity). Together with MPHOSPH8, mediates silencing of protocadherin genes in the nervous system (PubMed:36332029)., [UniProtKB, PubMed, UniProtKB, PubMed]; Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5QNQ7;Q6P547", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0140719 constitutive heterochromatin formation;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q69ZX6-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5UKY4-1", "uniprot_id": [ { "id": "MO2R3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5UKY4", "type": "external" } ], "mass": 33625.0, "length": 296, "protein_name": "Cell surface glycoprotein CD200 receptor 3", "gene_name": "Cd200r3", "organism": "Mouse", "refseq_name": "cell surface glycoprotein CD200 receptor 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001121604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121604", "type": "external" } ], "gene_names_uniprotkb": "Cd200r3; Cd200rlb", "gene_names_refseq": "4733401I18Rik; 4833409J19Rik; Cd200r3; mCD200RLb", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 3; CD200 cell surface glycoprotein receptor-like 3; CD200 cell surface glycoprotein receptor-like b; CD200 receptor-like 3; CD200RLb; Cell surface glycoprotein OX2 receptor 3", "protein_names_refseq": "CD200 cell surface glycoprotein receptor 3; CD200 cell surface glycoprotein receptor-like 3; CD200 cell surface glycoprotein receptor-like b; CD200 receptor-like 3; CD200RLb; cell surface glycoprotein CD200 receptor 3 isoform 1 precursor; cell surface glycoprotein CD200 receptor 3; cell surface glycoprotein OX2 receptor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74603)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12960329;14644999;15187158;15274657;15471863;16081818;17982101;21750661", "class_list": "", "function": "According to PubMed:15187158 isoform 4 is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein. Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor. Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; CD200R3 functions as an activating receptor on mast cells and basophils to regulate IgE-independent immune responses in cooperation with an inhibitory receptor CD200R, [RefSeq, PubMed]; During parasitic helminth infection, we identified CD200 receptor-like 3 as a transcript highly expressed in basophils and mast cells, [RefSeq, PubMed]; Expression of the immunoregulatory protein CD200 increases as murine dendritic cells undergo apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3F9;Q5UKY1;Q5UKY2;Q5UKY3;Q5UKY5;Q6XJV5;Q9D628;Q9D642", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5UKY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61474-1", "uniprot_id": [ { "id": "MSI1H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61474", "type": "external" } ], "mass": 39119.0, "length": 362, "protein_name": "RNA-binding protein Musashi homolog 1", "gene_name": "Msi1", "organism": "Mouse", "refseq_name": "RNA-binding protein Musashi homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_032655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032655", "type": "external" } ], "gene_names_uniprotkb": "Msi1; Msi1h", "gene_names_refseq": "Msi1h; Msi1; Musahi1; m-Msi-1", "protein_names_uniprotkb": "RNA-binding protein Musashi homolog 1; Musashi-1", "protein_names_refseq": "Musashi homolog 1(Drosophila); RNA-binding protein Musashi homolog 1 isoform 1; RNA-binding protein Musashi homolog 1; musashi-1", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306); brain ischemia (Disease Ontology:DOID:2316); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:17690)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10080895;11359897;12407178;12907678;16554442;21750661;37858462;38879014;8660864", "class_list": "", "function": "RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells., [RefSeq, PubMed]; The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNC7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003727 single-stranded RNA binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0030855 epithelial cell differentiation;GO:0007417 central nervous system development;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61474-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62000-1", "uniprot_id": [ { "id": "MIME_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62000", "type": "external" } ], "mass": 34012.0, "length": 298, "protein_name": "Mimecan", "gene_name": "Ogn", "organism": "Mouse", "refseq_name": "mimecan precursor", "refseq_ac": [ { "id": "NP_032786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032786", "type": "external" } ], "gene_names_uniprotkb": "Ogn; Og", "gene_names_refseq": "3110079A16Rik; OG; OIF; Ogn; SLRR3A; mimecan; mimican", "protein_names_uniprotkb": "Mimecan; Osteoglycin", "protein_names_refseq": "mimecan precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18295); (R-MMU-2022854); (R-MMU-2022857)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "36657194;37507081;37828378;7607548", "class_list": "glycogene", "function": "Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice - A preliminary study., [RefSeq, PubMed]; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0048662 negative regulation of smooth muscle cell proliferation;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62000-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PZE0-1", "uniprot_id": [ { "id": "MUC19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PZE0", "type": "external" } ], "mass": 693499.0, "length": 7524, "protein_name": "Mucin-19", "gene_name": "Muc19", "organism": "Mouse", "refseq_name": "mucin-19 precursor", "refseq_ac": [ { "id": "NP_997126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997126", "type": "external" } ], "gene_names_uniprotkb": "Muc19", "gene_names_refseq": "MUC-19; Muc19; sld", "protein_names_uniprotkb": "Mucin-19; Gel-forming secreted mucin-19; MUC-19; Sublingual apomucin", "protein_names_refseq": "gel-forming secreted mucin-19; mucin-19 precursor; sublingual apomucin", "tax_id": 10090, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (mmu:239611); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12847143;12882755;15340121;30779550;35820727", "class_list": "", "function": "May function in ocular mucus homeostasis., [UniProtKB]", "predicted_glycosites": 37, "predicted_n_glycosites": 0, "predicted_o_glycosites": 37, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 37, "binding_glycan_count": 0, "secondary_ac_list": "A7UN62;A7UN63;A7UN64;A7UN66;Q6P7U5;Q6Y0X6;Q80UR5", "ec_number_list": [], "go_molecular_function": "GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0070098 chemokine-mediated signaling pathway;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PZE0-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XJV6-1", "uniprot_id": [ { "id": "MO2R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6XJV6", "type": "external" } ], "mass": 27408.0, "length": 249, "protein_name": "Cell surface glycoprotein CD200 receptor 2", "gene_name": "Cd200r1l", "organism": "Mouse", "refseq_name": "cell surface glycoprotein CD200 receptor 2 precursor", "refseq_ac": [ { "id": "NP_996258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996258", "type": "external" } ], "gene_names_uniprotkb": "Cd200r1l; Cd200r2", "gene_names_refseq": "Cd200r1l; Cd200r2", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 2; CD200 cell surface glycoprotein receptor-like 2; CD200 cell surface glycoprotein receptor-like c; CD200 receptor-like 2; CD200RLc; Cell surface glycoprotein OX2 receptor 2", "protein_names_refseq": "CD200 cell surface glycoprotein receptor-like 2; CD200 cell surface glycoprotein receptor-like c; CD200 cell surface glycoprotein receptor; CD200 receptor-like 2; CD200RLc; cell surface glycoprotein CD200 receptor 2 precursor; cell surface glycoprotein CD200 receptor 2; cell surface glycoprotein OX2 receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:271375); (R-MMU-198933)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15187158;15274657;15471863;16081818;18424714;24142033", "class_list": "", "function": "According to PubMed:15187158 it is a receptor for the CD200 cell surface glycoprotein. According to PubMed:16081818 it is not a receptor for the CD200/OX2 cell surface glycoprotein. Involved in the recruitment or surface expression of the TYROBP receptor., [UniProtKB, PubMed, PubMed, PubMed]; An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells., [RefSeq, PubMed]; Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs., [RefSeq, PubMed]; The CD200 receptor family consists of both activatory and inhibitory members, like several other paired ligand receptors., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6XJV6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78J03-1", "uniprot_id": [ { "id": "MSRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78J03", "type": "external" } ], "mass": 19157.0, "length": 175, "protein_name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "gene_name": "Msrb2", "organism": "Mouse", "refseq_name": "methionine-R-sulfoxide reductase B2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_083895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083895", "type": "external" } ], "gene_names_uniprotkb": "Msrb2", "gene_names_refseq": "2310050L06Rik; Mrsb; Msrb2; Msrb; Pilb", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B2, mitochondrial; 1.8.4.12; 1.8.4.14; MsrB2", "protein_names_refseq": "methionine-R-sulfoxide reductase B2, mitochondrial precursor; methionine-R-sulfoxide reductase B2, mitochondrial; pilin-like transcription factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:76467); (R-MMU-5676934)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14699060;18505275;19250613;23911929;31078523;31282614;36288343", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance., [UniProtKB, PubMed, PubMed]; Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy., [RefSeq, PubMed]; Results show that mammalian MsrB and MsrA proteins perform crucial functions in protection against oxidative stress in lower eukaryotic yeast cells., [RefSeq, PubMed]; Studies show all Met sulfoxide residues in an MRP can be reduced by MsrA and MsrB., [RefSeq, PubMed]; The role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q78J03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TM99-1", "uniprot_id": [ { "id": "MOT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TM99", "type": "external" } ], "mass": 55757.0, "length": 508, "protein_name": "Monocarboxylate transporter 9", "gene_name": "Slc16a9", "organism": "Mouse", "refseq_name": "monocarboxylate transporter 9", "refseq_ac": [ { "id": "NP_080083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080083", "type": "external" } ], "gene_names_uniprotkb": "Slc16a9; Mct9", "gene_names_refseq": "1200003C15Rik; 4930425B13Rik; Slc16a9", "protein_names_uniprotkb": "Monocarboxylate transporter 9; MCT 9; Solute carrier family 16 member 9", "protein_names_refseq": "MCT 9; monocarboxylate transporter 9; solute carrier family 16 member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:66859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20022372", "class_list": "", "function": "Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter., [UniProtKB, UniProtKB]; In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P652", "ec_number_list": [], "go_molecular_function": "GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0005308 creatine transmembrane transporter activity;GO:0015226 carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046415 urate metabolic process;GO:1902603 carnitine transmembrane transport;GO:0015881 creatine transmembrane transport;GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TM99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UM7-1", "uniprot_id": [ { "id": "MOGS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UM7", "type": "external" } ], "mass": 91831.0, "length": 834, "protein_name": "Mannosyl-oligosaccharide glucosidase", "gene_name": "Mogs", "organism": "Mouse", "refseq_name": "mannosyl-oligosaccharide glucosidase", "refseq_ac": [ { "id": "NP_065644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065644", "type": "external" } ], "gene_names_uniprotkb": "Mogs; Gcs1", "gene_names_refseq": "1810017N02Rik; Gcs1; Mogs", "protein_names_uniprotkb": "Mannosyl-oligosaccharide glucosidase; 3.2.1.106; ER glu I; Endoplasmic reticulum alpha-glucosidase I; Glucosidase 1; Glycoprotein-processing glucosidase I", "protein_names_refseq": "ER glu I; endoplasmic reticulum alpha-glucosidase I; glucosidase 1; glycoprotein-processing glucosidase I; mannosyl-oligosaccharide glucosidase", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIb (Disease Ontology:DOID:0070254)", "pathway": " (mmu:57377); (R-MMU-9768727)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10406845;20485683;25428506;26740625;29187734;29465311;32227946;34428180;37453647", "class_list": "glycogene;glycosylhydrolase", "function": "(Microbial infection) Required for successful influenza or dengue virus infection; inhibition of its activity by a deoxynojirimycin derivative prevents death in mice infected with lethal doses of influenza or dengue viruses, even when administrated after infection., [UniProtKB, PubMed]; In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner., [UniProtKB, UniProtKB]; Increased GCS1 expression alleviates fatty acid-induced ER stress and is critical for suppressing ER stress-associated lipogenic gene activation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2W5", "ec_number_list": [ { "id": "3.2.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.106", "type": "external" } ], "go_molecular_function": "GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009311 oligosaccharide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80UM7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000011000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W94-1", "uniprot_id": [ { "id": "MOGT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W94", "type": "external" } ], "mass": 38591.0, "length": 334, "protein_name": "2-acylglycerol O-acyltransferase 2", "gene_name": "Mogat2", "organism": "Mouse", "refseq_name": "2-acylglycerol O-acyltransferase 2", "refseq_ac": [ { "id": "NP_803231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803231", "type": "external" } ], "gene_names_uniprotkb": "Mogat2; Dgat2l5; Mgat1l", "gene_names_refseq": "DGAT2L5; MGAT2; Mgat1l; Mogat2", "protein_names_uniprotkb": "2-acylglycerol O-acyltransferase 2; 2.3.1.20; 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 2; Diacylglycerol acyltransferase 2-like protein 5; MGAT2; Monoacylglycerol O-acyltransferase 1-like; Monoacylglycerol O-acyltransferase 2", "protein_names_refseq": "2-acylglycerol O-acyltransferase 2; acyl CoA:monoacylglycerol acyltransferase 2; diacylglycerol acyltransferase 2-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:233549); (R-MMU-75109)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12576479;12621063;12730219;14966132;30084848;31837122", "class_list": "", "function": "Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet., [RefSeq, PubMed]; Involved in glycerolipid synthesis and lipid metabolism (PubMed:12576479, PubMed:12621063, PubMed:12730219, PubMed:14966132). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (Probable). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:12730219). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 (PubMed:12730219). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol) (PubMed:12730219). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:12730219)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; MGAT catalyzes the synthesis of diacylglycerol, a precursor of triacylglycerol. MGAT mediates the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes, a step required for delivering absorbed fat to other tissues., [RefSeq, PubMed]; MGAT2 possessed an intrinsic acyl-CoA:diacylglycerol acyltransferase (DGAT) activity which could provide an alternative pathway for triacylglycerol synthesis in the absence of DGAT, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "2.3.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62", "type": "external" } ], "go_molecular_function": "GO:0016407 acetyltransferase activity;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1990578 perinuclear endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0050892 intestinal absorption;GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80W94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLU2-1", "uniprot_id": [ { "id": "MT21C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLU2", "type": "external" } ], "mass": 27892.0, "length": 248, "protein_name": "Protein-lysine methyltransferase METTL21C", "gene_name": "Mettl21c", "organism": "Mouse", "refseq_name": "protein-lysine methyltransferase METTL21C", "refseq_ac": [ { "id": "NP_001013821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013821", "type": "external" } ], "gene_names_uniprotkb": "Mettl21c", "gene_names_refseq": "A530098C11Rik; Mettl21c", "protein_names_uniprotkb": "Protein-lysine methyltransferase METTL21C; 2.1.1.-; Methyltransferase-like protein 21C", "protein_names_refseq": "methyltransferase like 21C; methyltransferase-like protein 21C; protein-lysine methyltransferase METTL21C", "tax_id": 10090, "disease": "", "pathway": " (mmu:433294)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24677265;29719249;31346037;32611769;38417894", "class_list": "", "function": "METTL21C mediates autophagy and formation of slow-twitch muscle fibers in mice after exercise., [RefSeq, PubMed]; METTL21C trimethylates p97 on the Lys315 residue and found that loss of this modification reduced p97 hexamer formation and ATPase activity in vivo., [RefSeq, PubMed]; Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue., [RefSeq, PubMed]; Mettl21c knockdown modulated only the NF-kappaB signaling pathway., [RefSeq, PubMed]; Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0008276 protein methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0071549 cellular response to dexamethasone stimulus;GO:0006479 protein methylation;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0008628 hormone-mediated apoptotic signaling pathway;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMQ8-1", "uniprot_id": [ { "id": "MON1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMQ8", "type": "external" } ], "mass": 60016.0, "length": 553, "protein_name": "Vacuolar fusion protein MON1 homolog B", "gene_name": "Mon1b", "organism": "Mouse", "refseq_name": "vacuolar fusion protein MON1 homolog B", "refseq_ac": [ { "id": "NP_001041608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041608", "type": "external" } ], "gene_names_uniprotkb": "Mon1b; Kiaa0872", "gene_names_refseq": "5031407H10; 5033413H12Rik; Mon1b", "protein_names_uniprotkb": "Vacuolar fusion protein MON1 homolog B", "protein_names_refseq": "vacuolar fusion protein MON1 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:270096); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20305638;25428506", "class_list": "", "function": "Data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZX1;Q6P5V5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005770 late endosome;GO:0035658 Mon1-Ccz1 complex", "go_biological_process": "GO:0019085 early viral transcription;GO:0019086 late viral transcription;GO:0016192 vesicle-mediated transport;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BMQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTP3-1", "uniprot_id": [ { "id": "MO2R5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTP3", "type": "external" } ], "mass": 29528.0, "length": 270, "protein_name": "Cell surface glycoprotein CD200 receptor 5", "gene_name": "Cd200r5", "organism": "Mouse", "refseq_name": "cell surface glycoprotein CD200 receptor 5 precursor", "refseq_ac": [ { "id": "NP_795984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795984", "type": "external" } ], "gene_names_uniprotkb": "Cd200r5", "gene_names_refseq": "Cd200r1l; Cd200r5; F630003A18Rik", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 5; CD200 cell surface glycoprotein receptor-like 5; CD200 cell surface glycoprotein receptor-like e; CD200 receptor-like 5; CD200RLe; Cell surface glycoprotein OX2 receptor 5", "protein_names_refseq": "CD200 cell surface glycoprotein receptor-like 5; CD200 cell surface glycoprotein receptor-like e; CD200 receptor-like 5; CD200RLe; cell surface glycoprotein CD200 receptor 5 precursor; cell surface glycoprotein CD200 receptor 5; cell surface glycoprotein OX2 receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:319823)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;16081818", "class_list": "", "function": "May not be a receptor for the CD200/OX2 cell surface glycoprotein., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTN8", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BTP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C160-1", "uniprot_id": [ { "id": "MSLNL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C160", "type": "external" } ], "mass": 74710.0, "length": 685, "protein_name": "Mesothelin-like protein", "gene_name": "Mslnl", "organism": "Mouse", "refseq_name": "mesothelin-like protein precursor", "refseq_ac": [ { "id": "NP_808490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808490", "type": "external" } ], "gene_names_uniprotkb": "Mslnl; Mpfl", "gene_names_refseq": "4732467B22; Mslnl", "protein_names_uniprotkb": "Mesothelin-like protein; Pre-pro-megakaryocyte-potentiating-factor-like", "protein_names_refseq": "mesothelin-like protein precursor; mesothelin-like protein; pre-pro-megakaryocyte-potentiating-factor-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:328783)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;34428180", "class_list": "", "function": "May play a role in cellular adhesion., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C160-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3F2-1", "uniprot_id": [ { "id": "MMP21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3F2", "type": "external" } ], "mass": 65454.0, "length": 568, "protein_name": "Matrix metalloproteinase-21", "gene_name": "Mmp21", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-21 isoform 1 precursor", "refseq_ac": [ { "id": "NP_694423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694423", "type": "external" } ], "gene_names_uniprotkb": "Mmp21", "gene_names_refseq": "Mmp21; b2b2458Clo; b2b873Clo", "protein_names_uniprotkb": "Matrix metalloproteinase-21; 3.4.24.-; MMP-21", "protein_names_refseq": "matrix metalloproteinase-21 isoform 1 precursor; matrix metalloproteinase-21", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 7 (Disease Ontology:DOID:0051021)", "pathway": " (mmu:214766)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12617721;19601983;26437028;26437029;35398966", "class_list": "", "function": "MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation., [RefSeq, PubMed]; Matrix metalloproteinase-21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC., [RefSeq, PubMed]; Plays a specialized role in the generation of left-right asymmetry during embryogenesis (PubMed:26437028). May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0007368 determination of left/right symmetry;GO:0060976 coronary vasculature development;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K3F2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0M8-1", "uniprot_id": [ { "id": "MOT5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0M8", "type": "external" } ], "mass": 55678.0, "length": 500, "protein_name": "Probable monocarboxylate transporter 5", "gene_name": "Slc16a4", "organism": "Mouse", "refseq_name": "probable monocarboxylate transporter 5 isoform 2", "refseq_ac": [ { "id": "NP_001297634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297634", "type": "external" } ], "gene_names_uniprotkb": "Slc16a4; Mct5", "gene_names_refseq": "MCT 5; Slc16a4", "protein_names_uniprotkb": "Probable monocarboxylate transporter 5; MCT 5", "protein_names_refseq": "monocarboxylate transporter 5; probable monocarboxylate transporter 5 isoform 2; probable monocarboxylate transporter 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:229699)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17599960;25762662;38733581", "class_list": "", "function": "Expression of cerebral MCT isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states., [RefSeq, PubMed]; Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Erratum:[Cell Rep. 2024 Oct 22;43(10):114884. doi: 10.1016/j.celrep.2024.114884. PMID: 39392757], [RefSeq, PubMed]; Probable monocarboxylate transporter., [UniProtKB, UniProtKB]; This study showed that mouse MCT1, MCT2, and MCT4 are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLA5;Q8BWE3;Q8R157", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R0M8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X96-1", "uniprot_id": [ { "id": "MSS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X96", "type": "external" } ], "mass": 13915.0, "length": 123, "protein_name": "Guanine nucleotide exchange factor MSS4", "gene_name": "Rabif", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange factor MSS4", "refseq_ac": [ { "id": "NP_663485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663485", "type": "external" } ], "gene_names_uniprotkb": "Rabif", "gene_names_refseq": "E130318E12Rik; MSS4; RASGFR3; Rabif", "protein_names_uniprotkb": "Guanine nucleotide exchange factor MSS4; Rab-interacting factor", "protein_names_refseq": "guanine nucleotide exchange factor MSS4; rab-interacting factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:98710)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25158853;34428180", "class_list": "", "function": "Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (By similarity)., [UniProtKB, UniProtKB]; MSS4 antagonizes Fsp27-mediated lipid droplet fusion activity through Rab8a., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2X4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91X96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YU3-1", "uniprot_id": [ { "id": "MSD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YU3", "type": "external" } ], "mass": 41247.0, "length": 345, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 4", "gene_name": "Msantd4", "organism": "Mouse", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 4", "refseq_ac": [ { "id": "NP_663584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663584", "type": "external" } ], "gene_names_uniprotkb": "Msantd4", "gene_names_refseq": "8430410K20Rik; Msantd4; Mysantd4", "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 4", "protein_names_refseq": "myb/SANT-like DNA-binding domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:78100)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91YU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZB9-1", "uniprot_id": [ { "id": "MRGB5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZB9", "type": "external" } ], "mass": 36285.0, "length": 322, "protein_name": "Mas-related G protein-coupled receptor member B5", "gene_name": "Mrgprb5", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B5", "refseq_ac": [ { "id": "NP_997421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997421", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb5; Mrgb5", "gene_names_refseq": "Mgrg11; MrgB5; Mrgprb5", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B5", "protein_names_refseq": "Mas-related G protein-coupled receptor g11; mas-related G-protein coupled receptor member B5", "tax_id": 10090, "disease": "", "pathway": " (mmu:404239)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZB9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZC1-1", "uniprot_id": [ { "id": "MRGB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZC1", "type": "external" } ], "mass": 35510.0, "length": 312, "protein_name": "Mas-related G protein-coupled receptor member B3", "gene_name": "Mrgprb3", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member B3", "refseq_ac": [ { "id": "NP_997420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997420", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb3; Mrgb3", "gene_names_refseq": "MrgB3; Mrgprb3", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B3", "protein_names_refseq": "mas-related G-protein coupled receptor member B3", "tax_id": 10090, "disease": "", "pathway": " (mmu:404238)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B813;Q3B814", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZC5-1", "uniprot_id": [ { "id": "MRGA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZC5", "type": "external" } ], "mass": 35034.0, "length": 305, "protein_name": "Mas-related G protein-coupled receptor member A7", "gene_name": "Mrgpra7", "organism": "Mouse", "refseq_name": "mas-related G-protein coupled receptor member A7", "refseq_ac": [ { "id": "NP_997418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997418", "type": "external" } ], "gene_names_uniprotkb": "Mrgpra7; Mrga7", "gene_names_refseq": "MrgA7; Mrgpra7", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member A7", "protein_names_refseq": "mas-related G-protein coupled receptor member A7", "tax_id": 10090, "disease": "", "pathway": " (mmu:404236)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11551509", "class_list": "", "function": "Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J25-1", "uniprot_id": [ { "id": "MRM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J25", "type": "external" } ], "mass": 34843.0, "length": 320, "protein_name": "rRNA methyltransferase 1, mitochondrial", "gene_name": "Mrm1", "organism": "Mouse", "refseq_name": "rRNA methyltransferase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_663408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663408", "type": "external" } ], "gene_names_uniprotkb": "Mrm1", "gene_names_refseq": "A530065E19Rik; Mrm1", "protein_names_uniprotkb": "rRNA methyltransferase 1, mitochondrial; 16S rRNA (guanosine(1145)-2'-O)-methyltransferase; 16S rRNA [Gm1145] 2'-O-methyltransferase; 2.1.1.-", "protein_names_refseq": "16S rRNA (guanosine(1145)-2'-O)-methyltransferase; 16S rRNA [Gm1145] 2'-O-methyltransferase; mitochondrial large ribosomal RNA ribose methylase; mitochondrial rRNA methyltransferase 1 homolog; rRNA methyltransferase 1, mitochondrial precursor; rRNA methyltransferase 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:217038)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24036117", "class_list": "", "function": "RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPX8;Q3U0Z5;Q5ND22", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000154 rRNA modification;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99J25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JI1-1", "uniprot_id": [ { "id": "MSTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JI1", "type": "external" } ], "mass": 8941.0, "length": 82, "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "Mustn1", "organism": "Mouse", "refseq_name": "musculoskeletal embryonic nuclear protein 1", "refseq_ac": [ { "id": "NP_852055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852055", "type": "external" } ], "gene_names_uniprotkb": "Mustn1", "gene_names_refseq": "1110028G01Rik; Mustang; Mustn1", "protein_names_uniprotkb": "Musculoskeletal embryonic nuclear protein 1", "protein_names_refseq": "musculoskeletal embryonic nuclear protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66175)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19410023;20130207;37170065;38094159;38458566", "class_list": "", "function": "Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice., [RefSeq, PubMed]; Mustn1 is a necessary regulator of chondrocyte function., [RefSeq, PubMed]; Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition., [RefSeq, PubMed]; Required for chondrocyte development and proliferation (PubMed:19410023). Plays a role in myoblast differentiation and fusion (PubMed:20130207). Modulates skeletal muscle extracellular matrix composition (PubMed:38458566). Plays a role in skeletal muscle function (PubMed:38094159). Plays a role in glucose homeostasis (PubMed:37170065)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This study demonstrates that Mustn1 is an essential regulator of myogenic differentiation and myofusion, and implicates Myod and Myog as its downstream targets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0007517 muscle organ development;GO:0030326 embryonic limb morphogenesis;GO:0042593 glucose homeostasis;GO:0032332 positive regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MZ3-1", "uniprot_id": [ { "id": "MLXPL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MZ3", "type": "external" } ], "mass": 94875.0, "length": 864, "protein_name": "Carbohydrate-responsive element-binding protein", "gene_name": "Mlxipl", "organism": "Mouse", "refseq_name": "carbohydrate-responsive element-binding protein isoform 1", "refseq_ac": [ { "id": "NP_067430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067430", "type": "external" } ], "gene_names_uniprotkb": "Mlxipl; Mio; Wbscr14", "gene_names_refseq": "ChREBP; Mlxipl; Mlx; WS-bHLH; Wbscr14; bHLHd14", "protein_names_uniprotkb": "Carbohydrate-responsive element-binding protein; ChREBP; MLX interactor; MLX-interacting protein-like; Williams-Beuren syndrome chromosomal region 14 protein homolog", "protein_names_refseq": "MLX interacting protein-like beta; MLX interactor; Max-like protein; Williams-Beuren syndrome chromosome region 14 homolog; carbohydrate-responsive element-binding protein isoform 1; carbohydrate-responsive element-binding protein; putative hepatic transcription factor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:58805)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10780788;11230181;17242355;18630941;21183079;21471514;21750661;22466288;23056614;25428506;25724563;28450420;28661453;31227231;34428180;40997131", "class_list": "", "function": "Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis. Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (PubMed:22466288). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (By similarity). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (PubMed:11230181). May also act as a transcriptional repressor (PubMed:11230181)., [UniProtKB, UniProtKB, PubMed, PubMed]; Glucose-responsive transcription factor, which, in complex with MLX, induces the transcription of isoform 6 from an alternative promoter., [UniProtKB, PubMed]; Transcription factor, which exhibits higher transcriptional activity than isoform 1., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "H9U1Q1;Q99MY9;Q99MZ0;Q99MZ1;Q99MZ2;Q9JLM5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99MZ3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY0-1", "uniprot_id": [ { "id": "MRM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY0", "type": "external" } ], "mass": 27145.0, "length": 246, "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "organism": "Mouse", "refseq_name": "rRNA methyltransferase 2, mitochondrial", "refseq_ac": [ { "id": "NP_080786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080786", "type": "external" } ], "gene_names_uniprotkb": "Mrm2; Ftsj2", "gene_names_refseq": "2310037B18Rik; Ftsj2; Mrm2", "protein_names_uniprotkb": "rRNA methyltransferase 2, mitochondrial; 16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; 2.1.1.-; Protein ftsJ homolog 2", "protein_names_refseq": "16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; FtsJ RNA methyltransferase homolog 2; FtsJ homolog 2; protein ftsJ homolog 2; putative ribosomal RNA methyltransferase 2; rRNA (uridine-2'-O-)-methyltransferase; rRNA methyltransferase 2, mitochondrial", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 17 (Disease Ontology:DOID:0070448); MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (mmu:68017)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24036117", "class_list": "", "function": "RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0001510 RNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CPY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQL7-1", "uniprot_id": [ { "id": "MOFA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQL7", "type": "external" } ], "mass": 14194.0, "length": 125, "protein_name": "MORF4 family-associated protein 1", "gene_name": "Mrfap1", "organism": "Mouse", "refseq_name": "MORF4 family-associated protein 1", "refseq_ac": [ { "id": "NP_080518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080518", "type": "external" } ], "gene_names_uniprotkb": "Mrfap1; MNCb-1039; Pam14", "gene_names_refseq": "9130413I22Rik; Mrfap1; Pam14", "protein_names_uniprotkb": "MORF4 family-associated protein 1; Protein associated with MRG of 14 kDa", "protein_names_refseq": "MORF4 family-associated protein 1; protein associated with MRG of 14 kDa; protein associated with MRG, 14 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:67568)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15367658;28315936", "class_list": "", "function": "Not essential for normal mouse development and cell cycle control, likely acts as an adaptor protein in nucleoprotein complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX68", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1Q1-1", "uniprot_id": [ { "id": "MPH6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1Q1", "type": "external" } ], "mass": 19086.0, "length": 161, "protein_name": "M-phase phosphoprotein 6", "gene_name": "Mphosph6", "organism": "Mouse", "refseq_name": "M-phase phosphoprotein 6 isoform 1", "refseq_ac": [ { "id": "NP_081034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081034", "type": "external" } ], "gene_names_uniprotkb": "Mphosph6", "gene_names_refseq": "1110001M01Rik; Mphosph6", "protein_names_uniprotkb": "M-phase phosphoprotein 6", "protein_names_refseq": "M-phase phosphoprotein 6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68533); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "32003502;34428180", "class_list": "", "function": "M-phase phosphoprotein 6 (MPP6) is important for 5.8S pre-rRNA maturation in somatic cells and was screened as a female fertility factor. MPP6 is required for 5.8S rRNA maturation, meiosis and quality control in mouse oocytes, and MPP6 level might be a marker for oocyte quality., [RefSeq, PubMed]; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2P8-1", "uniprot_id": [ { "id": "MOBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2P8", "type": "external" } ], "mass": 19197.0, "length": 170, "protein_name": "Myelin-associated oligodendrocyte basic protein", "gene_name": "Mobp", "organism": "Mouse", "refseq_name": "myelin-associated oligodendrocyte basic protein isoform b", "refseq_ac": [ { "id": "NP_001034454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034454", "type": "external" } ], "gene_names_uniprotkb": "Mobp", "gene_names_refseq": "MOBP155; MOBP170; MOBP69; MOBP73; MOBP81; Mobp", "protein_names_uniprotkb": "Myelin-associated oligodendrocyte basic protein", "protein_names_refseq": "myelin-associated oligodendrocyte basic protein isoform b; myelin-associated oligodendrocyte basic protein", "tax_id": 10090, "disease": "hypothyroidism (Disease Ontology:DOID:1459); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:17433)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10328883;16452087;21183079;26801084;8551331", "class_list": "", "function": "MOBP synthesis is stimulated by Fyn activity., [RefSeq, PubMed]; May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35713;Q792D7;Q792D8;Q9JLY4;Q9JLY5;Q9JLY6", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043209 myelin sheath;GO:0048471 perinuclear region of cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D2P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAI9-1", "uniprot_id": [ { "id": "MORN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAI9", "type": "external" } ], "mass": 20078.0, "length": 170, "protein_name": "MORN repeat-containing protein 5", "gene_name": "Morn5", "organism": "Mouse", "refseq_name": "MORN repeat-containing protein 5", "refseq_ac": [ { "id": "NP_083585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083585", "type": "external" } ], "gene_names_uniprotkb": "Morn5", "gene_names_refseq": "1700010A17Rik; Morn5", "protein_names_uniprotkb": "MORN repeat-containing protein 5", "protein_names_refseq": "MORN repeat-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:75495)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28742876", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPL5-1", "uniprot_id": [ { "id": "MMP1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPL5", "type": "external" } ], "mass": 53488.0, "length": 464, "protein_name": "Interstitial collagenase A", "gene_name": "Mmp1a", "organism": "Mouse", "refseq_name": "interstitial collagenase A preproprotein", "refseq_ac": [ { "id": "NP_114395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114395", "type": "external" } ], "gene_names_uniprotkb": "Mmp1a; McolA", "gene_names_refseq": "MMP-1a; Mcol-A; Mcola; Mmp1a", "protein_names_uniprotkb": "Interstitial collagenase A; 3.4.24.7; MMP-1a; Matrix metalloproteinase-1a; Mcol-A", "protein_names_refseq": "collagenase-like A; interstitial collagenase A preproprotein; interstitial collagenase A; matrix metalloproteinase 1a (interstitial collagenase)", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); scoliosis (Disease Ontology:DOID:0060249); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); carotid stenosis (Disease Ontology:DOID:13001); lung cancer (Disease Ontology:DOID:1324); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); atherosclerosis (Disease Ontology:DOID:1936); obstructive lung disease (Disease Ontology:DOID:2320); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); varicose veins (Disease Ontology:DOID:799); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); localized scleroderma (Disease Ontology:DOID:8472); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); tendinitis (Disease Ontology:DOID:971)", "pathway": " (mmu:83995)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11113146;33761760", "class_list": "", "function": "Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (By similarity). Able to degrade synthetic peptides and type I and II fibrillar collagen., [UniProtKB]; Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease., [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens. Mice lacking the encoded protein exhibit decreased susceptibility to chemical carcinogen-induced lung tumor development and angiogenesis. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149J4", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0031334 positive regulation of protein-containing complex assembly;GO:0010763 positive regulation of fibroblast migration;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPL5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHI0-1", "uniprot_id": [ { "id": "MMP19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHI0", "type": "external" } ], "mass": 59122.0, "length": 527, "protein_name": "Matrix metalloproteinase-19", "gene_name": "Mmp19", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-19 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_067387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067387", "type": "external" } ], "gene_names_uniprotkb": "Mmp19; Rasi", "gene_names_refseq": "Mmp19", "protein_names_uniprotkb": "Matrix metalloproteinase-19; 3.4.24.-; MMP-19; Matrix metalloproteinase RASI", "protein_names_refseq": "matrix metalloproteinase RASI; matrix metalloproteinase-19 isoform 1 preproprotein; matrix metalloproteinase-19", "tax_id": 10090, "disease": "relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)", "pathway": " (mmu:58223); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11054540;11092553;15169894;26495903;26555704;26700939", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity). Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity)., [UniProtKB]; Estrogen receptor beta target gene, where ERbeta requires a specific Sp1 site on the MMP-19 promoter to mediate ligand dependent transcription, [RefSeq, PubMed]; Mmp19-null mice develop a diet-induced obesity due to adipocyte hypertrophy and exhibit decreased susceptibility to skin tumors induced by chemical carcinogens., [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein develop a diet-induced obesity due to adipocyte hypertophy, exhibit decreased susceptibility to chemical carcinogen-induced skin tumors and early onset of tumoral angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]; This study shows that MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C360", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHI0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZW9-1", "uniprot_id": [ { "id": "MNX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZW9", "type": "external" } ], "mass": 41331.0, "length": 404, "protein_name": "Motor neuron and pancreas homeobox protein 1", "gene_name": "Mnx1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mnx1; Hlxb9", "gene_names_refseq": "", "protein_names_uniprotkb": "Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9", "protein_names_refseq": "", "tax_id": 10090, "disease": "Currarino syndrome (Disease Ontology:DOID:0111546)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10471502;18539116", "class_list": "", "function": "Transcription factor (PubMed:18539116). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (PubMed:18539116). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription cofactor LMO4 (PubMed:18539116). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking interactions of ISL1-LHX3 complexes with regulatory elements (PubMed:18539116). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (PubMed:10471502)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPC0", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001764 neuron migration;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZW9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVQ5-1", "uniprot_id": [ { "id": "MTNB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVQ5", "type": "external" } ], "mass": 26949.0, "length": 241, "protein_name": "Methylthioribulose-1-phosphate dehydratase", "gene_name": "Apip", "organism": "Mouse", "refseq_name": "methylthioribulose-1-phosphate dehydratase isoform 1", "refseq_ac": [ { "id": "NP_062709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062709", "type": "external" } ], "gene_names_uniprotkb": "Apip; Mmrp19", "gene_names_refseq": "APIP2; Apip; CGI-29; Mmrp19", "protein_names_uniprotkb": "Methylthioribulose-1-phosphate dehydratase; 4.2.1.109; APAF1-interacting protein; MTRu-1-P dehydratase; Monocyte/macrophage protein 19", "protein_names_refseq": "MTRu-1-P dehydratase; methylthioribulose-1-phosphate dehydratase isoform 1; monocyte macrophage 19; monocyte/macrophage protein 19; probable methylthioribulose-1-phosphate dehydratase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56369); (R-MMU-111458); (R-MMU-9627069)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15262985;17086211;25153642;28528544;31263105;37507081", "class_list": "", "function": "APIP functions to inhibit muscle ischemic damage by binding to Apaf-1 in the Apaf-1/caspase-9 apoptosis pathway., [RefSeq, PubMed]; APIP is crucial for cardioprotection against myocardial infarction by virtue of binding to and stabilizing ADORA2B, thereby dampening ischemic heart injury. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP46", "ec_number_list": [ { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "4.2.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.109", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046570 methylthioribulose 1-phosphate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051289 protein homotetramerization;GO:0006915 apoptotic process;GO:0070269 pyroptotic inflammatory response;GO:0070372 regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WVQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z223-2", "uniprot_id": [ { "id": "MOC2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z223", "type": "external" } ], "mass": 20924.0, "length": 189, "protein_name": "Molybdopterin synthase catalytic subunit", "gene_name": "Mocs2", "organism": "Mouse", "refseq_name": "molybdopterin synthase sulfur carrier subunit isoform Mocs2B", "refseq_ac": [ { "id": "NP_001106845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106845", "type": "external" } ], "gene_names_uniprotkb": "Mocs2", "gene_names_refseq": "Mocs2", "protein_names_uniprotkb": "Molybdopterin synthase catalytic subunit; 2.8.1.12; MOCS2B; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B", "protein_names_refseq": "MOCS2B; molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2B; molybdopterin synthase sulfur carrier subunit isoform Mocs2B; molybdopterin synthase sulfur carrier subunit", "tax_id": 10090, "disease": "molybdenum cofactor deficiency type B (Disease Ontology:DOID:0111163)", "pathway": " (mmu:17434)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10053003;27138983", "class_list": "", "function": "Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (By similarity)., [UniProtKB, HAMAP, UniProtKB]; Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. Based on experiments with the human molybdopterin synthase ortholog, they are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]., [RefSeq]; Mocs2-deficient mice recapitulate the severe phenotype observed in humans and can now serve as a model for preclinical therapeutic approaches for MoCo deficiency type B., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J206;Q8C5E5;Q8R1M7;Q9DCK1", "ec_number_list": [ { "id": "2.8.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030366 molybdopterin synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:1990140 molybdopterin synthase complex", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z223-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AMZ4-1", "uniprot_id": [ { "id": "NDUF8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AMZ4", "type": "external" } ], "mass": 7785.0, "length": 74, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8", "gene_name": "Ndufaf8", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8", "refseq_ac": [ { "id": "NP_001103712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103712", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf8; 1810043H04Rik", "gene_names_refseq": "1810043H04Rik; Ndufaf8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 34 (Disease Ontology:DOID:0112091)", "pathway": " (mmu:208501); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWC2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AMZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMW7-1", "uniprot_id": [ { "id": "NIPA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMW7", "type": "external" } ], "mass": 45159.0, "length": 416, "protein_name": "Magnesium transporter NIPA3", "gene_name": "Nipal1", "organism": "Mouse", "refseq_name": "magnesium transporter NIPA3", "refseq_ac": [ { "id": "NP_001074674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074674", "type": "external" } ], "gene_names_uniprotkb": "Nipal1; Nipa3; Npal1", "gene_names_refseq": "3830408G10Rik; Nipal1; Npal1", "protein_names_uniprotkb": "Magnesium transporter NIPA3; NIPA-like protein 1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 3 homolog", "protein_names_refseq": "NIPA-like protein 1; magnesium transporter NIPA3; non-imprinted in Prader-Willi/Angelman syndrome region protein 3 homolog", "tax_id": 10090, "disease": "hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:70701); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18667602;21750661;32439805", "class_list": "", "function": "Acts as a Mg(2+) transporter (PubMed:18667602). Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (PubMed:18667602). Shown to promote insulin content and secretion in Min6-K8 cells, particularly under conditions of hypomagnesemia (PubMed:32439805)., [UniProtKB, PubMed, PubMed]; The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BMW7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35130-1", "uniprot_id": [ { "id": "NEP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35130", "type": "external" } ], "mass": 26974.0, "length": 244, "protein_name": "Ribosomal RNA small subunit methyltransferase NEP1", "gene_name": "Emg1", "organism": "Mouse", "refseq_name": "ribosomal RNA small subunit methyltransferase NEP1 isoform 1", "refseq_ac": [ { "id": "NP_038564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038564", "type": "external" } ], "gene_names_uniprotkb": "Emg1; C2f; Grcc2f", "gene_names_refseq": "C2f; Emg1; Grcc2f", "protein_names_uniprotkb": "Ribosomal RNA small subunit methyltransferase NEP1; 18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA Psi1248 methyltransferase; 2.1.1.-; Nucleolar protein EMG1 homolog; Protein C2f; Ribosome biogenesis protein NEP1", "protein_names_refseq": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1; 18S rRNA Psi1248 methyltransferase; EMG1 nucleolar protein homolog; gene rich cluster, C2f; nucleolar protein EMG1 homolog; probable ribosome biogenesis protein NEP1; protein C2f; ribosomal RNA small subunit methyltransferase NEP1 isoform 1; ribosomal RNA small subunit methyltransferase NEP1", "tax_id": 10090, "disease": "Bowen-Conradi syndrome (Disease Ontology:DOID:0050684)", "pathway": " (mmu:14791); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "18299400;20858271;21183079;21750661;21952136;25428506;25428507;25605945;25708872;30084848;30779550;31599954;34428180;9445485", "class_list": "", "function": "Data demonstrate that Emg1 is highly expressed during mouse embryonic development, and essential for mouse pre-implantation development. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that Essential for Mitotic Growth 1 (EMG1) deficiency caused mitotic arrest and a halt in cell growth., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (By similarity). Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0070037 rRNA (pseudouridine) methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0017126 nucleologenesis;GO:0001824 blastocyst development;GO:0042274 ribosomal small subunit biogenesis;GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35130-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55066-1", "uniprot_id": [ { "id": "NCAN_MOUSE", "url": "https://www.uniprot.org/uniprot/P55066", "type": "external" } ], "mass": 137200.0, "length": 1268, "protein_name": "Neurocan core protein", "gene_name": "Ncan", "organism": "Mouse", "refseq_name": "neurocan core protein precursor", "refseq_ac": [ { "id": "NP_031815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031815", "type": "external" } ], "gene_names_uniprotkb": "Ncan; Cspg3", "gene_names_refseq": "C230035B04; Cspg3-rs; Cspg3; Ncan; Tgfbit", "protein_names_uniprotkb": "Neurocan core protein; Chondroitin sulfate proteoglycan 3", "protein_names_refseq": "TGFbeta-induced transcript, brain; chondroitin sulfate proteoglycan 3, related sequence; neurocan core protein precursor; neurocan core protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13004); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101); (R-MMU-3000178)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30899004;33300544;35822049;7490074", "class_list": "glycogene", "function": "May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 72, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1E3;Q8C4F8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0050804 modulation of chemical synaptic transmission;GO:0051823 regulation of synapse structural plasticity", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P55066-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R123-1", "uniprot_id": [ { "id": "NAA80_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R123", "type": "external" } ], "mass": 34583.0, "length": 314, "protein_name": "N-alpha-acetyltransferase 80", "gene_name": "Naa80", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 80", "refseq_ac": [ { "id": "NP_062724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062724", "type": "external" } ], "gene_names_uniprotkb": "Naa80; Fus2; Nat6", "gene_names_refseq": "Fus2; Naa80; Nat6", "protein_names_uniprotkb": "N-alpha-acetyltransferase 80; 2.3.1.-; N-acetyltransferase 6; Protein fus-2; Protein fusion-2 homolog", "protein_names_refseq": "N-acetyltransferase 6; N-alpha-acetyltransferase 80; protein fus-2; protein fusion-2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:56441)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11929860;21750661;34896361", "class_list": "", "function": "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3., [RefSeq, PubMed]; N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZY5;Q8R014;Q9ERM0", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0006473 protein acetylation;GO:0030047 actin modification;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R123-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52850-1", "uniprot_id": [ { "id": "NDST2_MOUSE", "url": "https://www.uniprot.org/uniprot/P52850", "type": "external" } ], "mass": 101202.0, "length": 883, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2", "gene_name": "Ndst2", "organism": "Mouse", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2", "refseq_ac": [ { "id": "NP_034941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034941", "type": "external" } ], "gene_names_uniprotkb": "Ndst2; Hsst2", "gene_names_refseq": "Mndns; NDST-2; Ndst2", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 2; Mndns; N-HSST 2; N-heparan sulfate sulfotransferase 2; NDST-2", "protein_names_refseq": "N-HSST 2; N-heparan sulfate sulfotransferase 2; [Heparan sulfate]-glucosamine N-sulfotransferase; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; glucosaminyl N-deacetylase/N-sulphotransferase 2; heparan N-sulfotransferase 2; heparan glucosaminyl N-deacetylase/N-sulfotransferase 2; heparan sulfate N-deacetylase/N-sulfotransferase 2; mastocytoma N-deacetylase/N-sulfotransferase", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (mmu:17423); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10466726;10466727;11087757;21750661;31219806;34428180;8144627;8294485", "class_list": "glycogene", "function": "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 51, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDF4;Q549P5", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0002448 mast cell mediated immunity;GO:0002002 regulation of angiotensin levels in blood", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P52850-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LY9-1", "uniprot_id": [ { "id": "NDUS5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LY9", "type": "external" } ], "mass": 12648.0, "length": 106, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5", "gene_name": "Ndufs5", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5", "refseq_ac": [ { "id": "NP_001025445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025445", "type": "external" } ], "gene_names_uniprotkb": "Ndufs5", "gene_names_refseq": "Ndufs5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; CI-15 kDa; Complex I-15 kDa; NADH-ubiquinone oxidoreductase 15 kDa subunit", "protein_names_refseq": "CI-15 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH-ubiquinone oxidoreductase 15 kDa subunit; complex I-15 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:595136); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;29187734;34428180;36288343;37453647;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U734", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99LY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70131-1", "uniprot_id": [ { "id": "NINJ1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70131", "type": "external" } ], "mass": 16555.0, "length": 152, "protein_name": "Ninjurin-1", "gene_name": "Ninj1", "organism": "Mouse", "refseq_name": "ninjurin-1 isoform 1", "refseq_ac": [ { "id": "NP_038638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038638", "type": "external" } ], "gene_names_uniprotkb": "Ninj1", "gene_names_refseq": "Ninj1", "protein_names_uniprotkb": "Ninjurin-1; Nerve injury-induced protein 1; Soluble ninjurin-1; sNinJ1", "protein_names_refseq": "nerve injury-induced protein 1; ninjurin-1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18081)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "19557008;21750661;23142597;23690620;24347169;24917672;24979788;25766274;25860173;26677008;27815839;28067406;29073078;30354207;30510259;30700695;31091274;31526566;32883094;33472215;36468682;37196676;37198476;37980412;38396301;38409108;39476863;9465296", "class_list": "", "function": "Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (PubMed:19557008, PubMed:33472215, PubMed:36468682, PubMed:37196676, PubMed:37198476, PubMed:39476863). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell (PubMed:33472215, PubMed:37196676, PubMed:37198476). Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (PubMed:33472215, PubMed:37196676, PubMed:37198476). Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane (PubMed:37198476). Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively (PubMed:33472215, PubMed:37196676, PubMed:37198476). Acts as an effector of PANoptosis downstream of CASP1, CASP4, CASP8 and RIPK3 (PubMed:38409108). Also induces plasma membrane rupture in response to cell swelling caused by osmotic stress and ferroptosis downstream of lipid peroxidation (PubMed:37980412, PubMed:38396301). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (PubMed:25860173). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (PubMed:24917672). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (PubMed:24347169, PubMed:24917672, PubMed:31526566). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:24917672, PubMed:30510259). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (PubMed:24917672, PubMed:30510259). Plays a role in nerve regeneration by promoting maturation of Schwann cells (PubMed:31526566). Acts as a regulator of angiogenesis (PubMed:25766274, PubMed:30354207). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (PubMed:25766274, PubMed:30354207). Also mediates vascular functions in penile tissue as well as vascular formation (PubMed:24979788). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (PubMed:30700695). Also involved in striated muscle growth and differentiation (PubMed:31091274). Also involved in cell senescence in a p53/TP53 manner, possibly by acting as an indirect regulator of p53/TP53 mRNA translation (PubMed:23690620, PubMed:29073078)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Ninj1 protein has an important role in vascular regression mediated by macrophages during early eye development and suggest the biological relevance of Ninj1 on vascular homeostasis., [RefSeq, PubMed]; Secreted form generated by cleavage, which has chemotactic activity (PubMed:23142597). Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis (PubMed:32883094)., [UniProtKB, PubMed, PubMed]; The N-terminal ectodomain of mouse Ninjurin1, which may act as a chemoattractant, is cleaved by MMP9., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0098632 cell-cell adhesion mediator activity;GO:0098631 cell adhesion mediator activity;GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0031527 filopodium membrane;GO:0097060 synaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:2001206 positive regulation of osteoclast development;GO:1990384 hyaloid vascular plexus regression;GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O70131-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ23-1", "uniprot_id": [ { "id": "NFU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ23", "type": "external" } ], "mass": 28568.0, "length": 255, "protein_name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "gene_name": "Nfu1", "organism": "Mouse", "refseq_name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001164062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164062", "type": "external" } ], "gene_names_uniprotkb": "Nfu1; Hirip5", "gene_names_refseq": "0610006G17Rik; CGI-33; Hirip5; Nfu1", "protein_names_uniprotkb": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; HIRA-interacting protein 5; mHIRIP5", "protein_names_refseq": "HIRA-interacting protein 5; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; histone cell cycle regulation defective interacting protein 5; mHIRIP5", "tax_id": 10090, "disease": "hereditary spastic paraplegia 93 (Disease Ontology:DOID:0070645); multiple mitochondrial dysfunctions syndrome 1 (Disease Ontology:DOID:0080133)", "pathway": " (mmu:56748); (R-MMU-9857492)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11342215;12915448;21750661;28135057;28528544", "class_list": "", "function": "Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULE0;Q6VNZ7;Q8CF80;Q9D1B7", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZ23-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63139-1", "uniprot_id": [ { "id": "NFYB_MOUSE", "url": "https://www.uniprot.org/uniprot/P63139", "type": "external" } ], "mass": 22787.0, "length": 207, "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "Nfyb", "organism": "Mouse", "refseq_name": "nuclear transcription factor Y subunit beta isoform a", "refseq_ac": [ { "id": "NP_035044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035044", "type": "external" } ], "gene_names_uniprotkb": "Nfyb", "gene_names_refseq": "Cbf-A; Nfyb", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit beta; CAAT box DNA-binding protein subunit B; NF-YB; Nuclear transcription factor Y subunit B", "protein_names_refseq": "CAAT box DNA-binding protein subunit B; NF-YB; nuclear transcription factor Y subunit B; nuclear transcription factor Y subunit beta isoform a; nuclear transcription factor Y subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:18045)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1549471;1577736;1698608;21750661;25428506;29704264;31219806;31599954;34428180;40997131", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB, UniProtKB, UniProtKB]; Study indentifies NF-Yb as a novel transcriptional regulator of Gria4 (GluA4 gene), and a controller of excitotoxic death in the oligodendroglial lineage; describes a novel regulatory region within Gria4 containing CCAAT sequences whose binding by NF-Yb is regulated by excitotoxicity. Excitotoxicity-induced alterations in NF-Yb binding are associated with changes in Gria4 transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22569;Q3UK54", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P63139-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCH2-1", "uniprot_id": [ { "id": "NHLC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCH2", "type": "external" } ], "mass": 38195.0, "length": 347, "protein_name": "NHL repeat-containing protein 3", "gene_name": "Nhlrc3", "organism": "Mouse", "refseq_name": "NHL repeat-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_766089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766089", "type": "external" } ], "gene_names_uniprotkb": "Nhlrc3", "gene_names_refseq": "4833441N19; 8030451K01Rik; Nhlrc3; mKIAA4083", "protein_names_uniprotkb": "NHL repeat-containing protein 3", "protein_names_refseq": "NHL repeat-containing protein 3 precursor; NHL repeat-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:212114); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26740625", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDW5", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CCH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E0CYC6-1", "uniprot_id": [ { "id": "NAT8B_MOUSE", "url": "https://www.uniprot.org/uniprot/E0CYC6", "type": "external" } ], "mass": 26389.0, "length": 232, "protein_name": "N-acetyltransferase 8B", "gene_name": "Nat8b-ps", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nat8b-ps; Cml2", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetyltransferase 8B; 2.3.1.-; ATase1; Acetyltransferase 1; Camello-like protein 2; Protein-lysine N6-acetyltransferase 8B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22267734;33846551", "class_list": "", "function": "Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (By similarity). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (PubMed:33846551)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0050435 amyloid-beta metabolic process;GO:0006084 acetyl-CoA metabolic process;GO:0016241 regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E0CYC6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTM4-1", "uniprot_id": [ { "id": "NF2L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTM4", "type": "external" } ], "mass": 72707.0, "length": 660, "protein_name": "Nuclear factor erythroid 2-related factor 3", "gene_name": "Nfe2l3", "organism": "Mouse", "refseq_name": "nuclear factor erythroid 2-related factor 3", "refseq_ac": [ { "id": "NP_035033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035033", "type": "external" } ], "gene_names_uniprotkb": "Nfe2l3; Nrf3", "gene_names_refseq": "Nfe2l3; Nrf3", "protein_names_uniprotkb": "Nuclear factor erythroid 2-related factor 3; NF-E2-related factor 3; NFE2-related factor 3; Nuclear factor, erythroid derived 2, like 3", "protein_names_refseq": "NF-E2-related factor 3; NFE2-related factor 3; nuclear factor erythroid 2-like 3; nuclear factor erythroid 2-related factor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18025)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10037736;15060151;19047052;21750661;35091681;36328531", "class_list": "", "function": "Activates erythroid-specific, globin gene expression., [UniProtKB]; Data are presented suggesting that the NHB2 sequence in mouse Nrf3 may regulate the topology of the transcription factor within the ER membrane, [RefSeq, PubMed]; Data show that Nrf3 null mice develop normally with no obvious phenotypic differences compared to wild-type animals, that they are fertile, and that gross anatomy as well as behavior appear normal., [RefSeq, PubMed]; Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment., [RefSeq, PubMed]; Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MH6-1", "uniprot_id": [ { "id": "NKD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MH6", "type": "external" } ], "mass": 52391.0, "length": 471, "protein_name": "Protein naked cuticle homolog 1", "gene_name": "Nkd1", "organism": "Mouse", "refseq_name": "protein naked cuticle homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_081556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081556", "type": "external" } ], "gene_names_uniprotkb": "Nkd1", "gene_names_refseq": "2810434J10Rik; 9030215G15Rik; Nkd1; Nkd", "protein_names_uniprotkb": "Protein naked cuticle homolog 1; Naked-1; mNkd1; mNkd", "protein_names_refseq": "mNkd1; mNkd; naked cuticle 1 homolog; naked-1; protein naked cuticle homolog 1 isoform 1; protein naked cuticle homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:93960)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11274398;11356022;15511637;15546883;15687260;16488995;17438140;21750661;37857014", "class_list": "", "function": "Cell autonomous antagonist of the canonical Wnt signaling pathway., [UniProtKB, UniProtKB]; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for spermatogenesis., [UniProtKB, PubMed, PubMed, PubMed]; Deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage, [RefSeq, PubMed]; Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt/beta-catenin and oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLD6;Q8K200;Q91Y46", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99MH6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TN7-1", "uniprot_id": [ { "id": "NAV3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TN7", "type": "external" } ], "mass": 252301.0, "length": 2359, "protein_name": "Neuron navigator 3", "gene_name": "Nav3", "organism": "Mouse", "refseq_name": "neuron navigator 3 isoform 2", "refseq_ac": [ { "id": "NP_001355744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355744", "type": "external" } ], "gene_names_uniprotkb": "Nav3; Kiaa0938; Pomfil1", "gene_names_refseq": "4732483H20Rik; 9630020C08Rik; Nav3; POMFIL1; Pomfil1p; mKIAA0938; unc53H3", "protein_names_uniprotkb": "Neuron navigator 3; Pore membrane and/or filament-interacting-like protein 1", "protein_names_refseq": "neuron navigator 3 isoform 2; pore membrane and/or filament-interacting-like protein 1; steerin 3", "tax_id": 10090, "disease": "cerebellar hypoplasia (Disease Ontology:DOID:0070338); opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (mmu:260315)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12062803;21183079;21750661;22517741;22645316;25428506;30084848;31219806;34428180;35820727;35822049;38977784;40885482", "class_list": "", "function": "Is involved in microtubule cytoskeleton organization and plays a role in cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Variants of NAV3, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005874 microtubule;GO:0005640 nuclear outer membrane;GO:1990752 microtubule end", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007399 nervous system development;GO:0030336 negative regulation of cell migration;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80TN7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6N5-1", "uniprot_id": [ { "id": "NC2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6N5", "type": "external" } ], "mass": 22278.0, "length": 205, "protein_name": "Dr1-associated corepressor", "gene_name": "Drap1", "organism": "Mouse", "refseq_name": "dr1-associated corepressor isoform 1", "refseq_ac": [ { "id": "NP_001278009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278009", "type": "external" } ], "gene_names_uniprotkb": "Drap1", "gene_names_refseq": "2310074H19Rik; Drap1; NC2-alpha", "protein_names_uniprotkb": "Dr1-associated corepressor; Dr1-associated protein 1; NC2-alpha; Negative cofactor 2-alpha", "protein_names_refseq": "Dr1 associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor isoform 1; dr1-associated corepressor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66556)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0017025 TBP-class protein binding;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex;GO:0017054 negative cofactor 2 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D6N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35657-1", "uniprot_id": [ { "id": "NEUR1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35657", "type": "external" } ], "mass": 44591.0, "length": 409, "protein_name": "Sialidase-1", "gene_name": "Neu1", "organism": "Mouse", "refseq_name": "sialidase-1 precursor", "refseq_ac": [ { "id": "NP_035023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035023", "type": "external" } ], "gene_names_uniprotkb": "Neu1; Neu", "gene_names_refseq": "Aglp; Apl; Bat-7; Bat7; G9; Map-2; Neu-1; Neu1; Neu", "protein_names_uniprotkb": "Sialidase-1; 3.2.1.18; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; Neuraminidase 1", "protein_names_refseq": "G9 sialidase; HLA-B-associated transcript 7; N-acetyl-alpha-neuraminidase 1; lysosomal sialidase; sialidase-1 precursor; sialidase-1", "tax_id": 10090, "disease": "mucolipidosis (Disease Ontology:DOID:0080488); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (mmu:18010); (R-MMU-4085001); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;14656967;30899004;31219806;32152506;34203471;34428180;37205763;37698928;38147151;38663826;9363440;9384611;9425240", "class_list": "glycogene;glycosylhydrolase", "function": "Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo., [RefSeq, PubMed]; Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage., [UniProtKB, PubMed, PubMed, PubMed]; Lysosomal sialidase NEU1, its intracellular properties, deficiency, and use as a therapeutic agent. Review article, [RefSeq, PubMed]; Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the immunoregulatory sialidase NEU1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O55220;Q99KG9", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0016997 alpha-sialidase activity;GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0010976 positive regulation of neuron projection development;GO:2000291 regulation of myoblast proliferation;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35657-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54709-1", "uniprot_id": [ { "id": "NKG2D_MOUSE", "url": "https://www.uniprot.org/uniprot/O54709", "type": "external" } ], "mass": 26710.0, "length": 232, "protein_name": "NKG2-D type II integral membrane protein", "gene_name": "Klrk1", "organism": "Mouse", "refseq_name": "NKG2-D type II integral membrane protein isoform b", "refseq_ac": [ { "id": "NP_001076791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076791", "type": "external" } ], "gene_names_uniprotkb": "Klrk1; Nkg2d", "gene_names_refseq": "D6H12S2489E; Klrk1; NKG2-D; Nkg2d", "protein_names_uniprotkb": "NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor", "protein_names_refseq": "NK cell receptor D; NKG2-D type II integral membrane protein isoform b; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; natural killer cell group 2D", "tax_id": 10090, "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704); anogenital venereal wart (Disease Ontology:DOID:11168); hepatitis C (Disease Ontology:DOID:1883); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); tuberculosis (Disease Ontology:DOID:399); histiocytoma (Disease Ontology:DOID:4231)", "pathway": " (mmu:27007); (R-MMU-198933); (R-MMU-2424491)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10894171;11224525;11248803;11557981;11567106;11825567;11973127;12150888;12370332;12426564;12426565;15048723;15189740;15294961;16086018;18394936;19144319;19631564;21898152;23298206;34428180;37774007;38282118;9464811;9600963", "class_list": "glycogene", "function": "Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice. Publication Status: Online-Only, [RefSeq, PubMed]; NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032394 MHC class Ib receptor activity;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0030246 carbohydrate binding;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0050830 defense response to Gram-positive bacterium;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O54709-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DN34-1", "uniprot_id": [ { "id": "NDUB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DN34", "type": "external" } ], "mass": 6954.0, "length": 57, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "gene_name": "Ndufb1", "organism": "Mouse", "refseq_name": "nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "refseq_ac": [ { "id": "NP_001365454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001365454", "type": "external" } ], "gene_names_uniprotkb": "Ndufb1", "gene_names_refseq": "100040297; CI-MNLL; Gm2695; Ndufb1-ps; Ndufb1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; CI-MNLL; Complex I-MNLL; NADH-ubiquinone oxidoreductase MNLL subunit", "protein_names_refseq": "Complex I-MNLL; NADH-ubiquinone oxidoreductase MNLL subunit; nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102631912); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016607 nuclear speck;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DN34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21661-1", "uniprot_id": [ { "id": "NEC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21661", "type": "external" } ], "mass": 70785.0, "length": 637, "protein_name": "Neuroendocrine convertase 2", "gene_name": "Pcsk2", "organism": "Mouse", "refseq_name": "neuroendocrine convertase 2 precursor", "refseq_ac": [ { "id": "NP_032818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032818", "type": "external" } ], "gene_names_uniprotkb": "Pcsk2; Nec-2; Nec2", "gene_names_refseq": "6330411F23Rik; Nec-2; Nec2; PC2; Pcsk2; Phpp-2; SPC2", "protein_names_uniprotkb": "Neuroendocrine convertase 2; 3.4.21.94; KEX2-like endoprotease 2; NEC 2; PC2; Prohormone convertase 2; Proprotein convertase 2", "protein_names_refseq": "KEX2-like endoprotease 2; NEC 2; neuroendocrine convertase 2 precursor; neuroendocrine convertase 2; prohormone convertase 2; proprotein convertase 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18549)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16452087;17467653;2169760;25333865;30899004;32928873;34203471;36560784", "class_list": "", "function": "Replication Activities of Major 5' Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:17467653). Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). Mediates the release of insulin from proinsulin (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80WU1", "ec_number_list": [ { "id": "3.4.21.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.94", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93", "type": "external" }, { "id": "3.4.17.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.10", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P21661-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35455-1", "uniprot_id": [ { "id": "NEU2_MOUSE", "url": "https://www.uniprot.org/uniprot/P35455", "type": "external" } ], "mass": 17900.0, "length": 168, "protein_name": "Vasopressin-neurophysin 2-copeptin", "gene_name": "Avp", "organism": "Mouse", "refseq_name": "vasopressin-neurophysin 2-copeptin preproprotein", "refseq_ac": [ { "id": "NP_033862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033862", "type": "external" } ], "gene_names_uniprotkb": "Avp", "gene_names_refseq": "Avp; Vp; Vsp", "protein_names_uniprotkb": "Vasopressin-neurophysin 2-copeptin; AVP-NPII; Arginine-vasopressin; Neurophysin-I", "protein_names_refseq": "AVP-NPII; pre-pro-arginine-vasopressin-neurophysin II; prepro-AVP-NP II; vasopressin-neurophysin 2-copeptin preproprotein; vasopressin-neurophysin 2-copeptin", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Wernicke-Korsakoff syndrome (Disease Ontology:DOID:10915); opioid abuse (Disease Ontology:DOID:11206); neurohypophyseal diabetes insipidus (Disease Ontology:DOID:12388); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); temporal lobe epilepsy (Disease Ontology:DOID:3328); hyperglycemia (Disease Ontology:DOID:4195); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:11998); (R-MMU-388479); (R-MMU-416476); (R-MMU-418555); (R-MMU-432040); (R-MMU-879518); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;14660745;2176709;30899004", "class_list": "", "function": "Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, UniProtKB]; Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2)., [UniProtKB, UniProtKB]; Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein., [UniProtKB, UniProtKB]; This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin binds to vasopressin receptors and functions as a vasopressor, to constrict blood vessels and increase blood pressure, and as an antidiuretic, to reduce the production of urine. Neurophysin 2 functions as a carrier protein in the transport of arginine vasopressin. This gene is present in a gene cluster with the related gene oxytocin on chromosome 2. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031894 V1A vasopressin receptor binding;GO:0031895 V1B vasopressin receptor binding;GO:0004672 protein kinase activity;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030425 dendrite", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:1990089 response to nerve growth factor;GO:0002125 maternal aggressive behavior;GO:0007621 negative regulation of female receptivity;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35455-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70352-1", "uniprot_id": [ { "id": "NAR5_MOUSE", "url": "https://www.uniprot.org/uniprot/P70352", "type": "external" } ], "mass": 34333.0, "length": 309, "protein_name": "Ecto-ADP-ribosyltransferase 5", "gene_name": "Art5", "organism": "Mouse", "refseq_name": "ecto-ADP-ribosyltransferase 5 isoform a precursor", "refseq_ac": [ { "id": "NP_001278283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278283", "type": "external" } ], "gene_names_uniprotkb": "Art5", "gene_names_refseq": "ARTC5; Art5; Yac-2", "protein_names_uniprotkb": "Ecto-ADP-ribosyltransferase 5; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 5; ARTC5; Mono(ADP-ribosyl)transferase 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5; YAC-2", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5; ecto-ADP-ribosyltransferase 5 isoform a precursor; ecto-ADP-ribosyltransferase 5; mono(ADP-ribosyl)transferase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:11875)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11587854;8703012", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QM95;O54739;Q91VF7;Q91X06;Q91X07;Q921A5", "ec_number_list": [ { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0003953 NAD+ nucleosidase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97334-1", "uniprot_id": [ { "id": "NKX23_MOUSE", "url": "https://www.uniprot.org/uniprot/P97334", "type": "external" } ], "mass": 38090.0, "length": 362, "protein_name": "Homeobox protein Nkx-2.3", "gene_name": "Nkx2-3", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.3", "refseq_ac": [ { "id": "NP_032725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032725", "type": "external" } ], "gene_names_uniprotkb": "Nkx2-3; Nkx-2.3; Nkx2c", "gene_names_refseq": "Nkx-2.3; Nkx2-3; Nkx2.3; nkx2-C; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.3; Homeobox protein NK-2 homolog 3; Homeobox protein NK-2 homolog C; Nkx2-C", "protein_names_refseq": "NK2 transcription factor related, locus 3; homeobox protein NK-2 homolog 3; homeobox protein NK-2 homolog C; homeobox protein Nkx-2.3", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:18089)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10790368;10926756;12141427;30084848;34428180;37095209;9142493", "class_list": "", "function": "Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy., [RefSeq, PubMed]; Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ60;Q9WV67", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0048621 post-embryonic digestive tract morphogenesis;GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97436-1", "uniprot_id": [ { "id": "NKX31_MOUSE", "url": "https://www.uniprot.org/uniprot/P97436", "type": "external" } ], "mass": 26824.0, "length": 237, "protein_name": "Homeobox protein Nkx-3.1", "gene_name": "Nkx3-1", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-3.1", "refseq_ac": [ { "id": "NP_035051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035051", "type": "external" } ], "gene_names_uniprotkb": "Nkx3-1; Nkx-3.1; Nkx3a", "gene_names_refseq": "Bax; NKX3.1; NKX3A; Nkx-3.1; Nkx3-1; bagpipe", "protein_names_uniprotkb": "Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A", "protein_names_refseq": "Drosophila NK-3 transcription factor, locus 1; homeobox protein NK-3 homolog A; homeobox protein Nkx-3.1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18095)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10215624;10415359;10906459;12036903;16814806;18816836;25428506;35820727;8943214;9142502", "class_list": "", "function": "Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate (PubMed:10215624). Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells (PubMed:12036903). Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands) (PubMed:10906459)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09087", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0090734 site of DNA damage", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97436-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TDX8-4", "uniprot_id": [ { "id": "NB5R4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TDX8", "type": "external" } ], "mass": 59716.0, "length": 528, "protein_name": "Cytochrome b5 reductase 4", "gene_name": "Cyb5r4", "organism": "Mouse", "refseq_name": "cytochrome b5 reductase 4 isoform 1", "refseq_ac": [ { "id": "NP_077157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077157", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r4; Ncb5or", "gene_names_refseq": "2810034J18Rik; B5+B5R; Cb5cb5r; Cyb5r4; Ncb5or; b5/b5r; b5b5r", "protein_names_uniprotkb": "Cytochrome b5 reductase 4; 1.6.2.2; Flavohemoprotein b5/b5R; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; b5+b5R; cb5/cb5R", "protein_names_refseq": "N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; cb5/cb5R; cytochrome b-type NAD(P)H oxidoreductase; cytochrome b5 reductase 4 isoform 1; flavohemoprotein b5/b5R", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:266690); (R-MMU-1237044)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10611283;14962668;15131110;15247412;16814408;21300801;21540332;22645316;24530354;27188291;28887630;34428180", "class_list": "", "function": "FFA accumulation and catabolism and oxidative stress are major consequences of Ncb5or deficiency in liver., [RefSeq, PubMed]; In livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of P450 oxidoreductase., [RefSeq, PubMed]; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS)., [UniProtKB, PubMed]; NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum, [RefSeq, PubMed]; Our findings suggest an essential role for NCB5OR in maintaining both iron homeostasis and the proper functioning of various locomotor pathways in the mouse cerebellum and midbrain., [RefSeq, PubMed]; The findings of this study suggest altered feeding response post starvation as a result of NCB5OR deficiency in the cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q129;Q3TJH3;Q3U012;Q6VXY4;Q6VXY5;Q8BJV8;Q8BTI5;Q8R3H8;Q99LY4;Q99P29", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0042593 glucose homeostasis;GO:0046677 response to antibiotic;GO:0072593 reactive oxygen species metabolic process;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3TDX8-4", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UG98-1", "uniprot_id": [ { "id": "NAT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UG98", "type": "external" } ], "mass": 27663.0, "length": 241, "protein_name": "Alpha/beta-tubulin-N-acetyltransferase 9", "gene_name": "Nat9", "organism": "Mouse", "refseq_name": "alpha/beta-tubulin-N-acetyltransferase 9 isoform 1", "refseq_ac": [ { "id": "NP_079676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079676", "type": "external" } ], "gene_names_uniprotkb": "Nat9", "gene_names_refseq": "1110028N05Rik; Nat9", "protein_names_uniprotkb": "Alpha/beta-tubulin-N-acetyltransferase 9; 2.3.1.308", "protein_names_refseq": "alpha/beta-tubulin-N-acetyltransferase 9 isoform 1; alpha/beta-tubulin-N-acetyltransferase 9; novel acetyltransferase protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66176)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28528544;34428180", "class_list": "", "function": "N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1G5;Q9D151", "ec_number_list": [ { "id": "2.3.1.308", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.308", "type": "external" } ], "go_molecular_function": "GO:0120519 tubulin N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UG98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UJ81-1", "uniprot_id": [ { "id": "NEPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UJ81", "type": "external" } ], "mass": 14267.0, "length": 125, "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "Cnep1r1", "organism": "Mouse", "refseq_name": "nuclear envelope phosphatase-regulatory subunit 1", "refseq_ac": [ { "id": "NP_083350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083350", "type": "external" } ], "gene_names_uniprotkb": "Cnep1r1; Tmem188", "gene_names_refseq": "5033428A16Rik; Cnep1r1; NEP1-R1; Tmem188", "protein_names_uniprotkb": "Nuclear envelope phosphatase-regulatory subunit 1; NEP1-R1; Transmembrane protein 188", "protein_names_refseq": "nuclear envelope phosphatase-regulatory subunit 1; transmembrane protein 188", "tax_id": 10090, "disease": "", "pathway": " (mmu:382030); (R-MMU-4419969)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;22134922;22872234;25428506;30084848", "class_list": "", "function": "Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity)., [UniProtKB]; Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E1Z4;Q8VEG8;Q9D3Q4", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0071595 Nem1-Spo7 phosphatase complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0034504 protein localization to nucleus;GO:0010867 positive regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UJ81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URJ8-1", "uniprot_id": [ { "id": "NKAI3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URJ8", "type": "external" } ], "mass": 20700.0, "length": 181, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3", "gene_name": "Nkain3", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001277339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277339", "type": "external" } ], "gene_names_uniprotkb": "Nkain3; Fam77d", "gene_names_refseq": "C530048M05; E130310K16Rik; Nkain3", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3; Protein FAM77D", "protein_names_refseq": "Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 1; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:269513)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;17606467", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ANL4;A6MHP8;A6MHQ0;Q6DI91;Q8BPL2;Q8C7P6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61220-1", "uniprot_id": [ { "id": "NELL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61220", "type": "external" } ], "mass": 91432.0, "length": 819, "protein_name": "Protein kinase C-binding protein NELL2", "gene_name": "Nell2", "organism": "Mouse", "refseq_name": "protein kinase C-binding protein NELL2 precursor", "refseq_ac": [ { "id": "NP_001276582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276582", "type": "external" } ], "gene_names_uniprotkb": "Nell2; Mel91", "gene_names_refseq": "A330108N19Rik; Nell2; mel91", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL2; MEL91 protein; NEL-like protein 2", "protein_names_refseq": "NEL-like protein 2; nel-like 2 homolog; protein kinase C-binding protein NELL2 precursor; protein kinase C-binding protein NELL2", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:54003)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15094495;15988128;21750661;26586761;30899004;32198364;32499443;37095084;40885482", "class_list": "", "function": "Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility., [UniProtKB, PubMed, PubMed]; NELL2 plays an important role as a novel suppressor in long-term potentiation in vivo in the mouse dentate gyrus, [RefSeq, PubMed]; NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2., [RefSeq, PubMed]; Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity) (PubMed:26586761, PubMed:32198364). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:26586761, PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80UM5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0046543 development of secondary female sexual characteristics;GO:0009566 fertilization;GO:0040008 regulation of growth;GO:0070050 neuron cellular homeostasis;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q61220-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62414-1", "uniprot_id": [ { "id": "NDF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62414", "type": "external" } ], "mass": 41493.0, "length": 383, "protein_name": "Neurogenic differentiation factor 2", "gene_name": "Neurod2", "organism": "Mouse", "refseq_name": "neurogenic differentiation factor 2", "refseq_ac": [ { "id": "NP_035025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035025", "type": "external" } ], "gene_names_uniprotkb": "Neurod2; Ndrf", "gene_names_refseq": "Ndrf; Neurod2; bHLHa1", "protein_names_uniprotkb": "Neurogenic differentiation factor 2; NDRF; NeuroD-related factor; NeuroD2", "protein_names_refseq": "neuroD-related factor; neurogenic differentiation factor 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 72 (Disease Ontology:DOID:0112208)", "pathway": " (mmu:18013)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10648228;10814830;11356028;14697366;16203979;16504944;16730830;18214987;19900895;20346398;8607837;8816493", "class_list": "", "function": "Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61952;Q925V5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008306 associative learning;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62414-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSC3-1", "uniprot_id": [ { "id": "NEK5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSC3", "type": "external" } ], "mass": 71790.0, "length": 627, "protein_name": "Serine/threonine-protein kinase Nek5", "gene_name": "Nek5", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek5 isoform 2", "refseq_ac": [ { "id": "NP_001334247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334247", "type": "external" } ], "gene_names_uniprotkb": "Nek5", "gene_names_refseq": "6530411J22; Nek5", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek5; 2.7.11.1; Never in mitosis A-related kinase 5; NimA-related protein kinase 5", "protein_names_refseq": "never in mitosis A-related kinase 5; nimA-related protein kinase 5; serine/threonine-protein kinase Nek5 isoform 2; serine/threonine-protein kinase Nek5", "tax_id": 10090, "disease": "", "pathway": " (mmu:330721)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23727203", "class_list": "", "function": "Nek5 promotes myogenic differentiation through up-regulation of caspase-3 activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6N6;Q8CCJ0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0051155 positive regulation of striated muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TSC3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHK1-1", "uniprot_id": [ { "id": "NIPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHK1", "type": "external" } ], "mass": 34105.0, "length": 323, "protein_name": "Magnesium transporter NIPA1", "gene_name": "Nipa1", "organism": "Mouse", "refseq_name": "magnesium transporter NIPA1", "refseq_ac": [ { "id": "NP_705806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705806", "type": "external" } ], "gene_names_uniprotkb": "Nipa1; Spg6", "gene_names_refseq": "1110027G09Rik; A830014A18Rik; FSP3; Nipa1; Spg6", "protein_names_uniprotkb": "Magnesium transporter NIPA1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 homolog", "protein_names_refseq": "magnesium transporter NIPA1; non-imprinted in Prader-Willi/Angelman syndrome region protein 1 homolog; spastic paraplegia 6 homolog", "tax_id": 10090, "disease": "hereditary spastic paraplegia 6 (Disease Ontology:DOID:0110811); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:233280); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14508708;17166836;20484733;25428506;30084848;30779550;34428180;35820727", "class_list": "", "function": "Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+)., [UniProtKB, PubMed]; Indentification on mouse chromosome 7C, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BHK1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZW8-1", "uniprot_id": [ { "id": "NHLC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZW8", "type": "external" } ], "mass": 78430.0, "length": 725, "protein_name": "NHL repeat-containing protein 2", "gene_name": "Nhlrc2", "organism": "Mouse", "refseq_name": "NHL repeat-containing protein 2", "refseq_ac": [ { "id": "NP_080087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080087", "type": "external" } ], "gene_names_uniprotkb": "Nhlrc2", "gene_names_refseq": "1200003G01Rik; Nhlrc2", "protein_names_uniprotkb": "NHL repeat-containing protein 2", "protein_names_refseq": "NHL repeat-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66866); (R-MMU-114608)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;28135057;28528544;29423877;31219806;33297935;34428180;35258166;37507081", "class_list": "", "function": "Nhlrc2 is crucial during mouse gastrulation., [RefSeq, PubMed]; Required for normal embryonic development., [UniProtKB, PubMed, UniProtKB]; Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XU0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BZW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K120-1", "uniprot_id": [ { "id": "NFAC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K120", "type": "external" } ], "mass": 95782.0, "length": 901, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 4", "gene_name": "Nfatc4", "organism": "Mouse", "refseq_name": "nuclear factor of activated T-cells, cytoplasmic 4 isoform 2", "refseq_ac": [ { "id": "NP_001161818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161818", "type": "external" } ], "gene_names_uniprotkb": "Nfatc4; Nfat3", "gene_names_refseq": "3110041H08Rik; Nfat3; Nfatc4", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 4; NF-AT3; NF-ATc4; NFATc4; T-cell transcription factor NFAT3", "protein_names_refseq": "NF-AT3; T-cell transcription factor NFAT3; nuclear factor of activated T-cells, cytoplasmic 4 isoform 2; nuclear factor of activated T-cells, cytoplasmic 4; transcription complex subunit NF-ATc4", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:73181)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11344309;11997522;12370307;12750314;17198697;17213202;17579027;18354019;18675896;18691762;19538478;21183079;21435446;21750661;22586092;24970700;25215946;25663301;35820727;38639863;38810124;9568714", "class_list": "", "function": "Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314). Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter (PubMed:17198697). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (PubMed:17198697)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury., [RefSeq, PubMed]; NFATc4 is not regulated by calcineurin and is not essential for hypertrophic growth, [RefSeq, PubMed]; Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases., [RefSeq, PubMed]; The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B5B2X2;Q3TXW7;Q9EP91", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8K120-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1R7-1", "uniprot_id": [ { "id": "NEK9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1R7", "type": "external" } ], "mass": 107143.0, "length": 984, "protein_name": "Serine/threonine-protein kinase Nek9", "gene_name": "Nek9", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek9", "refseq_ac": [ { "id": "NP_660120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660120", "type": "external" } ], "gene_names_uniprotkb": "Nek9; Nercc", "gene_names_refseq": "C130021H08Rik; Nek9", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek9; 2.7.11.38; Nercc1 kinase; Never in mitosis A-related kinase 9; NimA-related protein kinase 9", "protein_names_refseq": "nercc1 kinase; never in mitosis A-related kinase 9; nimA-related protein kinase 9; serine/threonine-protein kinase Nek9", "tax_id": 10090, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378)", "pathway": " (mmu:217718); (R-MMU-2980767)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;21183079;23159858;25153642;25217585;26495903;26522158;28528544;34078910;34428180;38176677;39627609", "class_list": "", "function": "Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction., [RefSeq, PubMed]; Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores., [RefSeq, PubMed]; NEK9 is a critical component of the replication stress response that promotes CHK1 activity, maintaining genome integrity following challenges to DNA replication., [RefSeq, PubMed]; NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Publication Status: Online-Only, [RefSeq, PubMed]; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148U2;Q8R3P1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K1R7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3J1-1", "uniprot_id": [ { "id": "NDUS8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3J1", "type": "external" } ], "mass": 24038.0, "length": 212, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "gene_name": "Ndufs8", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "refseq_ac": [ { "id": "NP_001258372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258372", "type": "external" } ], "gene_names_uniprotkb": "Ndufs8", "gene_names_refseq": "CI-23kD; Ndufs8; TYKY", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; 7.1.1.2; CI-23kD; Complex I-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH-ubiquinone oxidoreductase 23 kDa subunit; complex I-23kD", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 2 (Disease Ontology:DOID:0112083); Leigh disease (Disease Ontology:DOID:3652); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:225887); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16452087;21750661;22645316;31536960;32574643;34428180;36288343;37453647;38575788;38594244", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:38575788). Essential for the catalytic activity and assembly of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]; The requirement of the mitochondrial protein NDUFS8 for angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0016020 membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K3J1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2G4-5", "uniprot_id": [ { "id": "NAR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2G4", "type": "external" } ], "mass": 42015.0, "length": 371, "protein_name": "Ecto-ADP-ribosyltransferase 3", "gene_name": "Art3", "organism": "Mouse", "refseq_name": "ecto-ADP-ribosyltransferase 3 isoform 3 precursor", "refseq_ac": [ { "id": "NP_001297594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297594", "type": "external" } ], "gene_names_uniprotkb": "Art3", "gene_names_refseq": "4930569O04Rik; ARTC3; Art3", "protein_names_uniprotkb": "Ecto-ADP-ribosyltransferase 3; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 3; ARTC3; Mono(ADP-ribosyl)transferase 3; NAD(P)(+)--arginine ADP-ribosyltransferase 3", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 3; ART3 mono(ADP-ribosyl)transferase; NAD(P)(+)--arginine ADP-ribosyltransferase 3; ecto-ADP-ribosyltransferase 3 isoform 3 precursor; ecto-ADP-ribosyltransferase 3; mono(ADP-ribosyl)transferase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:109979); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12070318;34428180;36288343", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RUC2;O54738;Q8R2F9;Q8R2G0;Q8R2G1;Q8R2G2;Q8R2G3", "ec_number_list": [ { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.17.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.12", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R2G4-5", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WV0-1", "uniprot_id": [ { "id": "NC2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WV0", "type": "external" } ], "mass": 19431.0, "length": 176, "protein_name": "Protein Dr1", "gene_name": "Dr1", "organism": "Mouse", "refseq_name": "protein Dr1", "refseq_ac": [ { "id": "NP_080382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080382", "type": "external" } ], "gene_names_uniprotkb": "Dr1", "gene_names_refseq": "1700121L09Rik; Dr1l; Dr1; NC2beta; NC2", "protein_names_uniprotkb": "Protein Dr1; Down-regulator of transcription 1; NC2-beta; Negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein", "protein_names_refseq": "NC2-beta; TATA-binding protein-associated phosphoprotein; negative cofactor 2-beta; protein Dr1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13486); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;28735899;34432265;37394124", "class_list": "", "function": "Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis., [RefSeq, PubMed]; Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells., [RefSeq, PubMed]; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)., [UniProtKB]; The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT14", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0072686 mitotic spindle;GO:0017054 negative cofactor 2 complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922L6-1", "uniprot_id": [ { "id": "NELFD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922L6", "type": "external" } ], "mass": 66276.0, "length": 591, "protein_name": "Negative elongation factor D", "gene_name": "Nelfcd", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nelfcd; Nelfd; Th1l; Th1", "gene_names_refseq": "", "protein_names_uniprotkb": "Negative elongation factor D; NELF-D; TH1-like protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:57314); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11030415;11923845;17335777;18250455;20484733;21952136;26010750;30779550;31219806;34428180;36210013", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ05;Q9QXC8;Q9QXC9;Q9QXD0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032021 NELF complex", "go_biological_process": "GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0160239 transcription pausing by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q922L6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000100000000.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MA9-1", "uniprot_id": [ { "id": "NKX61_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MA9", "type": "external" } ], "mass": 37705.0, "length": 365, "protein_name": "Homeobox protein Nkx-6.1", "gene_name": "Nkx6-1", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-6.1", "refseq_ac": [ { "id": "NP_659204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659204", "type": "external" } ], "gene_names_uniprotkb": "Nkx6-1; Nkx6.1; Nkx6a", "gene_names_refseq": "NKX6A; Nkx6-1; Nkx6.1", "protein_names_uniprotkb": "Homeobox protein Nkx-6.1; Homeobox protein NK-6 homolog A", "protein_names_refseq": "Drosophila NK transcription factor related, gene family 6, locus 1; NK6 transcription factor related, locus 1; homeobox protein NK-6 homolog A; homeobox protein Nkx-6.1; homeodomain transcription factor Nkx6.1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18096)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10830170;10938085;11076772", "class_list": "", "function": "Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Required for the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (PubMed:11076772). Involved in transcriptional regulation of the insulin gene. Together with NKX2-2 and IRX3, restricts the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQP4;Q9ERQ7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MA9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQM0-1", "uniprot_id": [ { "id": "NICN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQM0", "type": "external" } ], "mass": 24360.0, "length": 213, "protein_name": "Nicolin-1", "gene_name": "Nicn1", "organism": "Mouse", "refseq_name": "nicolin-1 isoform 1", "refseq_ac": [ { "id": "NP_079725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079725", "type": "external" } ], "gene_names_uniprotkb": "Nicn1", "gene_names_refseq": "1500032A17Rik; Nicn1; PGs5; p24", "protein_names_uniprotkb": "Nicolin-1; PGs5; Tubulin polyglutamylase complex subunit 5; p24", "protein_names_refseq": "nicolin-1 isoform 1; tubulin polyglutamylase complex subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66257)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12392556;15890843", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRB2-1", "uniprot_id": [ { "id": "NHP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRB2", "type": "external" } ], "mass": 17247.0, "length": 153, "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "Nhp2", "organism": "Mouse", "refseq_name": "H/ACA ribonucleoprotein complex subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_080907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080907", "type": "external" } ], "gene_names_uniprotkb": "Nhp2; Nola2", "gene_names_refseq": "2410130M07Rik; D11Ertd175e; Nhp2; Nola2", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 2; Nucleolar protein family A member 2; snoRNP protein NHP2", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit 2 isoform 1; H/ACA small nucleolar RNPs; NHP2 ribonucleoprotein homolog; h/ACA ribonucleoprotein complex subunit 2; nucleolar protein family A, member 2; snoRNP protein NHP2", "tax_id": 10090, "disease": "autosomal recessive dyskeratosis congenita 2 (Disease Ontology:DOID:0070017)", "pathway": " (mmu:52530); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "25428506;31219806;34428180", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0034513 box H/ACA snoRNA binding;GO:0034511 U3 snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0090661 box H/ACA telomerase RNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CRB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWG8-1", "uniprot_id": [ { "id": "NDUF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWG8", "type": "external" } ], "mass": 48385.0, "length": 436, "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "Ndufaf7", "organism": "Mouse", "refseq_name": "protein arginine methyltransferase NDUFAF7, mitochondrial precursor", "refseq_ac": [ { "id": "NP_082887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082887", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf7", "gene_names_refseq": "2410091C18Rik; Ndufaf7; PRO1853", "protein_names_uniprotkb": "Protein arginine methyltransferase NDUFAF7, mitochondrial; 2.1.1.320; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; Protein midA homolog", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor; protein arginine methyltransferase NDUFAF7, mitochondrial; protein midA homolog, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:73694); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;24838397;28135057", "class_list": "", "function": "Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NDUFAF7 functions to methylate NDUFS2 after it assembles into a complex I, stabilizing an early intermediate in the assembly pathway, and that this function is essential for normal vertebrate development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLM6;Q8C1X3", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3P9-1", "uniprot_id": [ { "id": "NEUT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3P9", "type": "external" } ], "mass": 19608.0, "length": 169, "protein_name": "Neurotensin/neuromedin N", "gene_name": "Nts", "organism": "Mouse", "refseq_name": "neurotensin/neuromedin N isoform 1 precursor", "refseq_ac": [ { "id": "NP_077755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077755", "type": "external" } ], "gene_names_uniprotkb": "Nts", "gene_names_refseq": "5033428E16Rik; NMN-125; NN; NT/N; NTS1; NT; Nts", "protein_names_uniprotkb": "Neurotensin/neuromedin N; NmN-125", "protein_names_refseq": "neurotensin/neuromedin N isoform 1 precursor; neurotensin/neuromedin N", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sciatic neuropathy (Disease Ontology:DOID:11446); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:67405); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11427716;14699144", "class_list": "", "function": "Neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression, [RefSeq, PubMed]; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071855 neuropeptide receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0030133 transport vesicle", "go_biological_process": "GO:0090325 regulation of locomotion involved in locomotory behavior;GO:0007218 neuropeptide signaling pathway;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3P9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBW3-1", "uniprot_id": [ { "id": "NATD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBW3", "type": "external" } ], "mass": 12731.0, "length": 110, "protein_name": "Protein NATD1", "gene_name": "Natd1", "organism": "Mouse", "refseq_name": "protein NATD1", "refseq_ac": [ { "id": "NP_079570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079570", "type": "external" } ], "gene_names_uniprotkb": "Natd1; Gm16515; Gtlf3b", "gene_names_refseq": "F3-2; Gm16515; Gtlf3b; Natd1", "protein_names_uniprotkb": "Protein NATD1; Gene trap locus protein F3-2; Gene trap locus protein F3b; N-acetyltransferase domain-containing protein 1", "protein_names_refseq": "N-acetyltransferase domain-containing protein 1; gene trap locus F3b; gene trap locus protein F3-2; gene trap locus protein F3b; protein GTLF3B; protein NATD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:24083)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10402672;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCT2-1", "uniprot_id": [ { "id": "NDUS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCT2", "type": "external" } ], "mass": 30149.0, "length": 263, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "Ndufs3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080964", "type": "external" } ], "gene_names_uniprotkb": "Ndufs3", "gene_names_refseq": "0610010M09Rik; CI-30kD; Ndufs3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; 7.1.1.2; CI-30kD; Complex I-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit", "protein_names_refseq": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; NADH-ubiquinone oxidoreductase 30 kDa subunit; complex I-30kD", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); nuclear type mitochondrial complex I deficiency 8 (Disease Ontology:DOID:0112081); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:68349); (R-MMU-611105); (R-MMU-6799198); (R-MMU-9013408); (R-MMU-9837999)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "26495903;31536960;31916679;33148885;33300544;34428180;36288343;37453647;37507081;38569495;38575788;39927985", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:31916679, PubMed:33148885, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:31916679, PubMed:33148885)., [UniProtKB, PubMed, PubMed, PubMed]; SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTZ3;Q8R073", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043209 myelin sheath;GO:0016604 nuclear body", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DCT2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMG4-1", "uniprot_id": [ { "id": "NKAI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMG4", "type": "external" } ], "mass": 23042.0, "length": 208, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4", "gene_name": "Nkain4", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001135405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135405", "type": "external" } ], "gene_names_uniprotkb": "Nkain4; Fam77a", "gene_names_refseq": "C030019F02Rik; Nkain4", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4; Protein FAM77A", "protein_names_refseq": "Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:58237)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10679242;17606467;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9585, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AWN3;A6MHQ2;A6MHQ3;Q5EBQ3;Q9D1V9;Q9D8W0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JMG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTK5-1", "uniprot_id": [ { "id": "NFKB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTK5", "type": "external" } ], "mass": 96832.0, "length": 899, "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "Nfkb2", "organism": "Mouse", "refseq_name": "nuclear factor NF-kappa-B p100 subunit isoform a", "refseq_ac": [ { "id": "NP_001170840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170840", "type": "external" } ], "gene_names_uniprotkb": "Nfkb2", "gene_names_refseq": "NF-kappaB2; Nfkb2; lyt; p49/p100; p49; p50B; p52", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2", "protein_names_refseq": "DNA-binding factor KBF2; NF kappaB2; nuclear factor NF-kappa-B p100 subunit isoform a; nuclear factor NF-kappa-B p100 subunit", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); Parkinsonism (Disease Ontology:DOID:0080855); common variable immunodeficiency 10 (Disease Ontology:DOID:0081152); common variable immunodeficiency (Disease Ontology:DOID:12177); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:18034); (R-MMU-1810476); (R-MMU-3134963); (R-MMU-3214841); (R-MMU-445989); (R-MMU-448706); (R-MMU-4755510); (R-MMU-5607761); (R-MMU-5676590); (R-MMU-933542)", "pathway_count": 10, "publication_count": 18, "publication_id_list": "10398801;15084608;17242355;19144319;19224205;20173027;21183079;21750661;22872234;22894897;25153642;28135057;28528544;31219806;34203471;34428180;37816088;6124426", "class_list": "", "function": "NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity). In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer., [UniProtKB, UniProtKB, PubMed]; TRIM55 promotes noncanonical NF-kappaB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033257 Bcl3/NF-kappaB2 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9WTK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61361-1", "uniprot_id": [ { "id": "PGCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61361", "type": "external" } ], "mass": 95815.0, "length": 883, "protein_name": "Brevican core protein", "gene_name": "Bcan", "organism": "Mouse", "refseq_name": "brevican core protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001103228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103228", "type": "external" } ], "gene_names_uniprotkb": "Bcan", "gene_names_refseq": "Bcan; Cspg7", "protein_names_uniprotkb": "Brevican core protein", "protein_names_refseq": "brevican core protein isoform 2 precursor; brevican core protein", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); high grade glioma (Disease Ontology:DOID:3070); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:12032); (R-MMU-1474228); (R-MMU-1971475); (R-MMU-2022870); (R-MMU-2022923); (R-MMU-2024101); (R-MMU-3000178)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;14550776;17114649;21183079;21750661;22121037;22826440;26192747;29777959;30899004;33300544;40684658;40885482;9286696", "class_list": "glycogene", "function": "May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80WT7", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0021766 hippocampus development;GO:0007160 cell-matrix adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:1990138 neuron projection extension", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q61361-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG03-1", "uniprot_id": [ { "id": "PDE5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG03", "type": "external" } ], "mass": 98407.0, "length": 865, "protein_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "gene_name": "Pde5a", "organism": "Mouse", "refseq_name": "cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1", "refseq_ac": [ { "id": "NP_700471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700471", "type": "external" } ], "gene_names_uniprotkb": "Pde5a; Pde5", "gene_names_refseq": "Cgbpde; Cn5n; PDE5a2; Pde5a1; Pde5a; Pde5", "protein_names_uniprotkb": "cGMP-specific 3',5'-cyclic phosphodiesterase; 3.1.4.35; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase", "protein_names_refseq": "cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1; cGMP-specific 3',5'-cyclic phosphodiesterase", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); pre-eclampsia (Disease Ontology:DOID:10591); primary biliary cholangitis (Disease Ontology:DOID:12236); impotence (Disease Ontology:DOID:1875); IgA glomerulonephritis (Disease Ontology:DOID:2986); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:242202); (R-MMU-418457); (R-MMU-445355); (R-MMU-9013422)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "12554648;15576651;15665834;15668244;21750661;25428506;29145710;29341896;30084848;35767715;35820727;38030140;38738564", "class_list": "", "function": "Data show that recombinant cyclic GMP-binding phosphodiesterase 5 (PDE5) is activated directly upon cGMP binding to the GAF A domain, and this effect does not require PDE5 phosphorylation., [RefSeq, PubMed]; Findings show a much greater role of PDE5A in hearts subjected to sustained pressure load and that PDE5A inhibition in this setting prevents and reverses cardiac chamber, cellular and molecular remodeling induced by this stimulus, [RefSeq, PubMed]; PDE5A has a novel regulatory role in hearts under adrenergic stimulation. PDE5A catabolic regulation is specific coupled with NOS3-derived cGMP attributable to protein subcellular localization and targeted synthetic/catabolic coupling., [RefSeq, PubMed]; Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphodiesterase 5A regulates the vomeronasal pump in mice., [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sildenafil inhibits PDE5 and preconditions adult cardiac myocytes against necrosis and apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBW0", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0060282 positive regulation of oocyte development;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CG03-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A026-1", "uniprot_id": [ { "id": "PDS5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A026", "type": "external" } ], "mass": 150327.0, "length": 1332, "protein_name": "Sister chromatid cohesion protein PDS5 homolog A", "gene_name": "Pds5a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pds5a; Kiaa0648", "gene_names_refseq": "", "protein_names_uniprotkb": "Sister chromatid cohesion protein PDS5 homolog A", "protein_names_refseq": "", "tax_id": 10090, "disease": "Cornelia de Lange syndrome (Disease Ontology:DOID:11725)", "pathway": " (mmu:71521); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "18299400;21183079;21750661;23806337;25428506;28528544;30084848;31219806;34418053;34428180;34887587;39627609", "class_list": "", "function": "Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q656", "ec_number_list": [], "go_molecular_function": "GO:0140670 cohesin unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0051301 cell division;GO:0003007 heart morphogenesis;GO:0009952 anterior/posterior pattern specification;GO:0060021 roof of mouth development;GO:0001656 metanephros development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6A026-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97926-1", "uniprot_id": [ { "id": "OXYR_MOUSE", "url": "https://www.uniprot.org/uniprot/P97926", "type": "external" } ], "mass": 42805.0, "length": 388, "protein_name": "Oxytocin receptor", "gene_name": "Oxtr", "organism": "Mouse", "refseq_name": "oxytocin receptor isoform 1", "refseq_ac": [ { "id": "NP_001074616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074616", "type": "external" } ], "gene_names_uniprotkb": "Oxtr", "gene_names_refseq": "OTR; Oxtr", "protein_names_uniprotkb": "Oxytocin receptor; OT-R", "protein_names_refseq": "OT-R; oxytocin receptor isoform 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); substance abuse (Disease Ontology:DOID:302)", "pathway": " (mmu:18430); (R-MMU-388479); (R-MMU-416476)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16249339;19369205;21750661;25303526;25874674;26886170;27641503;31843930;38267576;38883814;40934325;9027321", "class_list": "", "function": "G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:19369205, PubMed:25303526, PubMed:25874674, PubMed:27641503, PubMed:31843930, PubMed:38267576, PubMed:40934325). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (By similarity). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:25303526, PubMed:25874674, PubMed:27641503, PubMed:38267576, PubMed:40934325). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (PubMed:16249339, PubMed:19369205, PubMed:31843930). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (PubMed:16249339)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ78", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004990 oxytocin receptor activity;GO:0035255 ionotropic glutamate receptor binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0005902 microvillus;GO:0016020 membrane", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0010701 positive regulation of norepinephrine secretion;GO:0001967 suckling behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97926-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PE55-1", "uniprot_id": [ { "id": "PGFRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PE55", "type": "external" } ], "mass": 41928.0, "length": 375, "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "Pdgfrl", "organism": "Mouse", "refseq_name": "platelet-derived growth factor receptor-like protein precursor", "refseq_ac": [ { "id": "NP_081116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081116", "type": "external" } ], "gene_names_uniprotkb": "Pdgfrl", "gene_names_refseq": "1110039P19Rik; Pdgfrl", "protein_names_uniprotkb": "Platelet-derived growth factor receptor-like protein; PDGFR-like protein", "protein_names_refseq": "PDGFR-like protein; platelet-derived growth factor receptor-like protein precursor; platelet-derived growth factor receptor-like protein", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:68797)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28407304", "class_list": "", "function": "These findings suggest that PDGFRL plays the different roles, depending upon cell types. Particularly, in chondrocytes, PDGFRL may play a new and important role which is distinct from the function previously reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V182;Q9D0Z1", "ec_number_list": [], "go_molecular_function": "GO:0005017 platelet-derived growth factor receptor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PE55-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A547-1", "uniprot_id": [ { "id": "PGRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/A1A547", "type": "external" } ], "mass": 38503.0, "length": 347, "protein_name": "Peptidoglycan recognition protein 3", "gene_name": "Pglyrp3", "organism": "Mouse", "refseq_name": "peptidoglycan recognition protein 3 precursor", "refseq_ac": [ { "id": "NP_997130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997130", "type": "external" } ], "gene_names_uniprotkb": "Pglyrp3; Gm420; Pgrpia", "gene_names_refseq": "Gm420; Pglyrp3", "protein_names_uniprotkb": "Peptidoglycan recognition protein 3; PGLYRPIalpha; PGRP-I-alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha", "protein_names_refseq": "PGLYRPIalpha; PGRP-I-alpha; peptidoglycan recognition protein 3 precursor; peptidoglycan recognition protein I-alpha; peptidoglycan recognition protein intermediate alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:242100); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15177568;25114103;26332373;33242664;34428180", "class_list": "", "function": "Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity)., [UniProtKB]; Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only, [RefSeq, PubMed]; Pglyrp3 deficiency resulted in colitis-predisposing intestinal microflora and increased intestinal ATP, [RefSeq, PubMed]; Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMH8;Q6R1Z2", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032827 negative regulation of natural killer cell differentiation involved in immune response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A1A547-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARM1-1", "uniprot_id": [ { "id": "PATL2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARM1", "type": "external" } ], "mass": 59639.0, "length": 529, "protein_name": "Protein PAT1 homolog 2", "gene_name": "Patl2", "organism": "Mouse", "refseq_name": "protein PAT1 homolog 2", "refseq_ac": [ { "id": "NP_080527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527", "type": "external" } ], "gene_names_uniprotkb": "Patl2", "gene_names_refseq": "4930424G05Rik; Pat1a; Patl2", "protein_names_uniprotkb": "Protein PAT1 homolog 2; PAT1-like protein 2; Pat1a; Protein PAT1 homolog a", "protein_names_refseq": "PAT1-like protein 2; protein PAT1 homolog 2; protein PAT1 homolog a", "tax_id": 10090, "disease": "ovarian disease (Disease Ontology:DOID:1100)", "pathway": " (mmu:67578)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20826699;34203471;35820727;37218508", "class_list": "", "function": "HPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion., [RefSeq, PubMed]; PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1., [RefSeq, PubMed]; RNA-binding protein that acts as a translational repressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5U9;Q9D5L4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030371 translation repressor activity;GO:0002151 G-quadruplex RNA binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0017148 negative regulation of translation;GO:0033962 P-body assembly;GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ARM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9M5-1", "uniprot_id": [ { "id": "PHOP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9M5", "type": "external" } ], "mass": 27563.0, "length": 241, "protein_name": "Pyridoxal phosphate phosphatase PHOSPHO2", "gene_name": "Phospho2", "organism": "Mouse", "refseq_name": "pyridoxal phosphate phosphatase PHOSPHO2", "refseq_ac": [ { "id": "NP_082797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082797", "type": "external" } ], "gene_names_uniprotkb": "Phospho2", "gene_names_refseq": "1700048E23Rik; Phos2; Phospho2", "protein_names_uniprotkb": "Pyridoxal phosphate phosphatase PHOSPHO2; 3.1.3.74", "protein_names_refseq": "pyridoxal phosphate phosphatase PHOSPHO2", "tax_id": 10090, "disease": "", "pathway": " (mmu:73373)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR04;Q3V1M5", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AUE5-1", "uniprot_id": [ { "id": "PEX10_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AUE5", "type": "external" } ], "mass": 37157.0, "length": 324, "protein_name": "Peroxisome biogenesis factor 10", "gene_name": "Pex10", "organism": "Mouse", "refseq_name": "peroxisome biogenesis factor 10", "refseq_ac": [ { "id": "NP_001035866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035866", "type": "external" } ], "gene_names_uniprotkb": "Pex10", "gene_names_refseq": "Gm142; Pex10", "protein_names_uniprotkb": "Peroxisome biogenesis factor 10; 2.3.2.27; Peroxin-10; Peroxisomal biogenesis factor 10; Peroxisome assembly protein 10", "protein_names_refseq": "peroxin-10; peroxisome assembly protein 10; peroxisome biogenesis factor 10", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 6A (Disease Ontology:DOID:0080481); Peroxisome biogenesis disorder 6B (Disease Ontology:DOID:0081435); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:668173); (R-MMU-8866654); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043335 protein unfolding;GO:0007031 peroxisome organization;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1AUE5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEG0-1", "uniprot_id": [ { "id": "PANX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEG0", "type": "external" } ], "mass": 44928.0, "length": 392, "protein_name": "Pannexin-3", "gene_name": "Panx3", "organism": "Mouse", "refseq_name": "pannexin-3", "refseq_ac": [ { "id": "NP_766042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766042", "type": "external" } ], "gene_names_uniprotkb": "Panx3", "gene_names_refseq": "3230401P04; 4833413G11Rik; Panx3", "protein_names_uniprotkb": "Pannexin-3", "protein_names_refseq": "pannexin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:208098)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17925379;18649185;19009624;19692571;21690309;21750661;31822768;38289985;38992988", "class_list": "", "function": "Collectively, diverse expression and distribution profiles of Panx1 and Panx3 suggest that they may have multiple cellular functions., [RefSeq, PubMed]; Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway., [RefSeq, PubMed]; Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress., [RefSeq, PubMed]; Panx1 can interact with Panx3 in a glycosylation-dependent manner. Panx3 can traffic to the cell surface and form functional single-membrane channels., [RefSeq, PubMed]; Regulator of osteoblast differentiation by functioning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors., [UniProtKB, PubMed]; Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in article text], [RefSeq, PubMed]; These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CB28", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005198 structural molecule activity;GO:0055077 gap junction hemi-channel activity;GO:0022829 wide pore channel activity;GO:0015267 channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006812 monoatomic cation transport;GO:0001649 osteoblast differentiation;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CEG0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0A0-1", "uniprot_id": [ { "id": "PEX14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0A0", "type": "external" } ], "mass": 41208.0, "length": 376, "protein_name": "Peroxisomal membrane protein PEX14", "gene_name": "Pex14", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein PEX14", "refseq_ac": [ { "id": "NP_062755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062755", "type": "external" } ], "gene_names_uniprotkb": "Pex14", "gene_names_refseq": "Pex14p; Pex14", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX14; PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14", "protein_names_refseq": "PTS1 receptor-docking protein; peroxin-14; peroxisomal membrane anchor protein PEX14; peroxisomal membrane protein PEX14", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 13A (Disease Ontology:DOID:0080487)", "pathway": " (mmu:56273); (R-MMU-8866654); (R-MMU-9033241); (R-MMU-9603798)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12488033;17242355;21750661;30084848;32831175;34428180;35917894", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008017 microtubule binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0001650 fibrillar center;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0036250 peroxisome transport along microtubule;GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043335 protein unfolding;GO:0007031 peroxisome organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0A0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAA7-1", "uniprot_id": [ { "id": "PGM2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAA7", "type": "external" } ], "mass": 70279.0, "length": 621, "protein_name": "Glucose 1,6-bisphosphate synthase", "gene_name": "Pgm2l1", "organism": "Mouse", "refseq_name": "glucose 1,6-bisphosphate synthase", "refseq_ac": [ { "id": "NP_081905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081905", "type": "external" } ], "gene_names_uniprotkb": "Pgm2l1", "gene_names_refseq": "4931406N15Rik; BM32A; Pgm2l1", "protein_names_uniprotkb": "Glucose 1,6-bisphosphate synthase; 2.7.1.106; Phosphoglucomutase-2-like 1", "protein_names_refseq": "glucose 1,6-bisphosphate synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:70974); (R-MMU-70171)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17804405;21183079;21750661;33300544", "class_list": "", "function": "Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors. In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.106", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004614 phosphoglucomutase activity;GO:0047933 glucose-1,6-bisphosphate synthase activity;GO:0016868 intramolecular phosphotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CAA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5N5-1", "uniprot_id": [ { "id": "PDD2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5N5", "type": "external" } ], "mass": 39955.0, "length": 364, "protein_name": "uS5 assembly chaperone PDCD2L", "gene_name": "Pdcd2l", "organism": "Mouse", "refseq_name": "uS5 assembly chaperone PDCD2L isoform 1", "refseq_ac": [ { "id": "NP_080825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080825", "type": "external" } ], "gene_names_uniprotkb": "Pdcd2l", "gene_names_refseq": "6030457N17Rik; Pdcd2l", "protein_names_uniprotkb": "uS5 assembly chaperone PDCD2L; Programmed cell death protein 2-like", "protein_names_refseq": "programmed cell death protein 2-like; uS5 assembly chaperone PDCD2L isoform 1; uS5 assembly chaperone PDCD2L", "tax_id": 10090, "disease": "", "pathway": " (mmu:68079)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;25605945;30084848;33055224;34428180", "class_list": "", "function": "May function as a chaperone for ribosomal protein uS5; its function appears redundant to PDCD2., [UniProtKB, UniProtKB]; Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R185;Q9D1M3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C5N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VA6-1", "uniprot_id": [ { "id": "PDIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VA6", "type": "external" } ], "mass": 41870.0, "length": 368, "protein_name": "Polymerase delta-interacting protein 2", "gene_name": "Poldip2", "organism": "Mouse", "refseq_name": "polymerase delta-interacting protein 2 precursor", "refseq_ac": [ { "id": "NP_080665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080665", "type": "external" } ], "gene_names_uniprotkb": "Poldip2", "gene_names_refseq": "1300003F06Rik; Pdip38; Poldip2", "protein_names_uniprotkb": "Polymerase delta-interacting protein 2", "protein_names_refseq": "mitogenin 1; mitogenin I; polymerase delta interacting protein 38; polymerase delta-interacting protein 2 precursor; polymerase delta-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67811)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16860483;21750661;31599954;34528082;34928942;35535614", "class_list": "", "function": "Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation., [RefSeq, PubMed]; Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1)., [UniProtKB, UniProtKB]; Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome., [RefSeq, PubMed]; Overexpression of Mitogenin I or mitochondrial single-stranded DNA-binding protein increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005911 cell-cell junction;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006281 DNA repair;GO:0045931 positive regulation of mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0051894 positive regulation of focal adhesion assembly;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91VA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NSR8-1", "uniprot_id": [ { "id": "PEPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NSR8", "type": "external" } ], "mass": 55940.0, "length": 524, "protein_name": "Probable aminopeptidase NPEPL1", "gene_name": "Npepl1", "organism": "Mouse", "refseq_name": "probable aminopeptidase NPEPL1 isoform 2", "refseq_ac": [ { "id": "NP_998898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998898", "type": "external" } ], "gene_names_uniprotkb": "Npepl1", "gene_names_refseq": "Npepl1; mKIAA1974", "protein_names_uniprotkb": "Probable aminopeptidase NPEPL1; 3.4.11.-; Aminopeptidase-like 1", "protein_names_refseq": "probable aminopeptidase NPEPL1 isoform 2; probable aminopeptidase NPEPL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228961)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACM6;Q66JY0", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NSR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03958-1", "uniprot_id": [ { "id": "PFD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03958", "type": "external" } ], "mass": 14455.0, "length": 127, "protein_name": "Prefoldin subunit 6", "gene_name": "Pfdn6", "organism": "Mouse", "refseq_name": "prefoldin subunit 6", "refseq_ac": [ { "id": "NP_001172111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001172111", "type": "external" } ], "gene_names_uniprotkb": "Pfdn6; H2-Ke2; Pfd6", "gene_names_refseq": "H-2Ke2; H2-Ke2; Ke-2; Pfdn6", "protein_names_uniprotkb": "Prefoldin subunit 6; Protein Ke2", "protein_names_refseq": "H2-K region expressed gene 2; prefoldin subunit 6; protein Ke2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14976)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1748305;18299400;21750661;25428506;25605945;26495903;26740625;28011936;30084848;30779550;31219806;34428180", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex;GO:1990062 RPAP3/R2TP/prefoldin-like complex", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:1905907 negative regulation of amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03958-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true } ]