[ { "uniprot_canonical_ac": "Q6PA06-1", "uniprot_id": [ { "id": "ATLA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PA06", "type": "external" } ], "mass": 66224.0, "length": 583, "protein_name": "Atlastin-2", "gene_name": "Atl2", "organism": "Mouse", "refseq_name": "atlastin-2 isoform 1", "refseq_ac": [ { "id": "NP_062691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062691", "type": "external" } ], "gene_names_uniprotkb": "Atl2; Arl6ip2", "gene_names_refseq": "2010110I21Rik; Aip-2; Arl6ip2; Atl2", "protein_names_uniprotkb": "Atlastin-2; 3.6.5.-", "protein_names_refseq": "ADP-ribosylation factor-like 6 interacting protein 2; ADP-ribosylation factor-like protein 6-interacting protein 2; ADP-ribosylation-like factor 6 interacting protein 2; ARL-6 interacting protein-2; atlastin-2 isoform 1; atlastin-2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:56298)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19665976;21750661;27669642;30879769;31219806;34428180;35820727;39927985", "class_list": "", "function": "Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (By similarity). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells., [RefSeq, PubMed]; The increase in lipid droplet size observed in the mammary epithelial cells of transgenic mice might result from changes to lipid droplet formation and secretion because of direct modifications to Atl2 expression and indirect changes to endoplasmic reticulum morphology resulting from the overexpression of miR-30b-5p, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX01;Q7TMM3", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0071346 cellular response to type II interferon;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6PA06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47757-1", "uniprot_id": [ { "id": "CAPZB_MOUSE", "url": "https://www.uniprot.org/uniprot/P47757", "type": "external" } ], "mass": 31345.0, "length": 277, "protein_name": "F-actin-capping protein subunit beta", "gene_name": "Capzb", "organism": "Mouse", "refseq_name": "F-actin-capping protein subunit beta isoform a", "refseq_ac": [ { "id": "NP_001032850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032850", "type": "external" } ], "gene_names_uniprotkb": "Capzb; Cappb1", "gene_names_refseq": "1700120C01Rik; CPB1; CPB2; CPbeat2; CPbeta1; CPbeta2; Cappb1; Capzb", "protein_names_uniprotkb": "F-actin-capping protein subunit beta; CapZ beta", "protein_names_refseq": "F-actin-capping protein subunit beta isoform a; F-actin-capping protein subunit beta; capZ beta; capping protein (actin filament) muscle Z-line, beta; capping protein beta 1", "tax_id": 10090, "disease": "dementia (Disease Ontology:DOID:1307); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:12345)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11465105;17242355;18250455;19341723;19806181;20969875;21540332;21750661;22645316;23806337;24788674;25153642;25428506;26495903;28011936;28135057;28528544;28935714;29187734;33300544;33564074;34260942;34428180;35984892;36288343;37507081;37828378;39627609;7929588", "class_list": "", "function": "Capping protein interacts with both actin protomers at the barbed end of the filament, and the amphipathic helix at the C-terminus of the beta-subunit binds to the hydrophobic cleft on actin., [RefSeq, PubMed]; Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules., [RefSeq, PubMed]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZbeta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMV7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005829 cytosol;GO:0005903 brush border;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0000902 cell morphogenesis;GO:0051016 barbed-end actin filament capping;GO:0007010 cytoskeleton organization;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P47757-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEL2-1", "uniprot_id": [ { "id": "CFA61_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEL2", "type": "external" } ], "mass": 143289.0, "length": 1252, "protein_name": "Cilia- and flagella-associated protein 61", "gene_name": "Cfap61", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cfap61; 4930529M08Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 61", "protein_names_refseq": "", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); spermatogenic failure 84 (Disease Ontology:DOID:0070583)", "pathway": " (mmu:78774)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34792097;35387802;37352829", "class_list": "", "function": "Involved in sperm flagellum assembly (PubMed:34792097, PubMed:35387802). Plays an essential role in the formation of the radial spokes in flagellum axoneme (PubMed:34792097, PubMed:35387802)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNX7;Q8R1E0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0002177 manchette;GO:0005930 axoneme", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0044782 cilium organization;GO:0007290 spermatid nucleus elongation;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEL2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM93-1", "uniprot_id": [ { "id": "AR6P4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM93", "type": "external" } ], "mass": 25525.0, "length": 229, "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 4", "gene_name": "Arl6ip4", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 6-interacting protein 4", "refseq_ac": [ { "id": "NP_653092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653092", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip4", "gene_names_refseq": "Aip-4; Arl6ip4; Srp25", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6-interacting protein 4; ARL-6-interacting protein 4; Aip-4; Splicing factor SRrp37", "protein_names_refseq": "ADP-ribosylation factor-like protein 6-interacting protein 4; ADP-ribosylation-like factor 6 interacting protein 4; ARL-6-interacting protein 4; SRp25 nuclear protein; splicing factor SRrp37", "tax_id": 10090, "disease": "", "pathway": " (mmu:65105)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10508919;10708573;21183079;21750661", "class_list": "", "function": "Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUG8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JM93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4V3-1", "uniprot_id": [ { "id": "CCD83_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4V3", "type": "external" } ], "mass": 35642.0, "length": 305, "protein_name": "Coiled-coil domain-containing protein 83", "gene_name": "Ccdc83", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 83 isoform 2", "refseq_ac": [ { "id": "NP_083532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083532", "type": "external" } ], "gene_names_uniprotkb": "Ccdc83", "gene_names_refseq": "4930549K11Rik; 4930554C01Rik; 4932423M01Rik; Ccdc83", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 83", "protein_names_refseq": "coiled-coil domain-containing protein 83 isoform 2; coiled-coil domain-containing protein 83", "tax_id": 10090, "disease": "", "pathway": " (mmu:75338)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEQ7;Q9D4W3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4V3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810T2-1", "uniprot_id": [ { "id": "CCNB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810T2", "type": "external" } ], "mass": 158969.0, "length": 1396, "protein_name": "G2/mitotic-specific cyclin-B3", "gene_name": "Ccnb3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccnb3; Cycb3", "gene_names_refseq": "", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:209091)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12185076;21183079;21750661", "class_list": "", "function": "Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810T3;Q8VDC8", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810T2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCQ2-1", "uniprot_id": [ { "id": "ASPDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCQ2", "type": "external" } ], "mass": 30270.0, "length": 287, "protein_name": "Aspartate dehydrogenase domain-containing protein", "gene_name": "Aspdh", "organism": "Mouse", "refseq_name": "aspartate dehydrogenase domain-containing protein", "refseq_ac": [ { "id": "NP_080966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080966", "type": "external" } ], "gene_names_uniprotkb": "Aspdh", "gene_names_refseq": "0610012D14Rik; Aspdh", "protein_names_uniprotkb": "Aspartate dehydrogenase domain-containing protein", "protein_names_refseq": "aspartate dehydrogenase domain-containing protein; putative L-aspartate dehydrogenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68352)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCQ0", "ec_number_list": [], "go_molecular_function": "GO:0033735 aspartate dehydrogenase [NAD(P)+] activity;GO:0050661 NADP binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMM4-1", "uniprot_id": [ { "id": "CDK10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMM4", "type": "external" } ], "mass": 40961.0, "length": 360, "protein_name": "Cyclin-dependent kinase 10", "gene_name": "Cdk10", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 10 isoform 2", "refseq_ac": [ { "id": "NP_919426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919426", "type": "external" } ], "gene_names_uniprotkb": "Cdk10", "gene_names_refseq": "Cdk10", "protein_names_uniprotkb": "Cyclin-dependent kinase 10; 2.7.11.22; Cell division protein kinase 10", "protein_names_refseq": "cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10; cyclin-dependent kinase 10 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234854)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16741970;21183079;21750661;22158035;28886341;8208557", "class_list": "", "function": "CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays., [RefSeq, PubMed]; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling., [UniProtKB, UniProtKB]; Data indicate that peptidyl-prolyl isomerase Pin1(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1(+/+) MEFs., [RefSeq, PubMed]; Data show that murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed., [RefSeq, PubMed]; Discusses PISSLRE, the human ortholog of mouse cyclin-dependent kinase 10., [RefSeq, PubMed]; The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZD2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0097472 cyclin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0036064 ciliary basal body;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UMM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA36-1", "uniprot_id": [ { "id": "CATAC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA36", "type": "external" } ], "mass": 37701.0, "length": 332, "protein_name": "Centrosomal AT-AC splicing factor", "gene_name": "Cenatac", "organism": "Mouse", "refseq_name": "centrosomal AT-AC splicing factor", "refseq_ac": [ { "id": "NP_958760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958760", "type": "external" } ], "gene_names_uniprotkb": "Cenatac; Ccdc84", "gene_names_refseq": "Ccdc84; Cenatac; D630044F24Rik; Gm1114", "protein_names_uniprotkb": "Centrosomal AT-AC splicing factor; Coiled-coil domain-containing protein 84", "protein_names_refseq": "centrosomal AT-AC splicing factor; coiled-coil domain containing 84; coiled-coil domain-containing protein 84", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome 4 (Disease Ontology:DOID:0060981)", "pathway": " (mmu:382073)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype. Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAL6;Q7TNQ4;Q8C702", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0051304 chromosome separation;GO:0042176 regulation of protein catabolic process;GO:0010826 negative regulation of centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VA36-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3R3-1", "uniprot_id": [ { "id": "CEP72_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3R3", "type": "external" } ], "mass": 72433.0, "length": 646, "protein_name": "Centrosomal protein of 72 kDa", "gene_name": "Cep72", "organism": "Mouse", "refseq_name": "centrosomal protein of 72 kDa", "refseq_ac": [ { "id": "NP_083235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083235", "type": "external" } ], "gene_names_uniprotkb": "Cep72; Kiaa1519", "gene_names_refseq": "2610029E11Rik; 4933440J22Rik; Cep72", "protein_names_uniprotkb": "Centrosomal protein of 72 kDa; Cep72", "protein_names_refseq": "centrosomal protein 72 kDa; centrosomal protein of 72 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:74470); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;34428180;34887587", "class_list": "", "function": "Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ95;Q3TU12;Q497H8;Q69ZH7;Q8BM53;Q9D0B7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007051 spindle organization;GO:0007099 centriole replication;GO:0033566 gamma-tubulin complex localization;GO:1904779 regulation of protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D3R3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3A1-1", "uniprot_id": [ { "id": "CDK15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3A1", "type": "external" } ], "mass": 48457.0, "length": 433, "protein_name": "Cyclin-dependent kinase 15", "gene_name": "Cdk15", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 15 isoform 1", "refseq_ac": [ { "id": "NP_001028545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028545", "type": "external" } ], "gene_names_uniprotkb": "Cdk15; Als2cr7; Pftk2", "gene_names_refseq": "Als2cr7; Cdk15; Pftk2", "protein_names_uniprotkb": "Cyclin-dependent kinase 15; 2.7.11.22; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog; Cell division protein kinase 15; Serine/threonine-protein kinase ALS2CR7; Serine/threonine-protein kinase PFTAIRE-2", "protein_names_refseq": "PFTAIRE protein kinase 2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog; cell division protein kinase 15; cyclin-dependent kinase 15 isoform 1; serine/threonine-protein kinase ALS2CR7; serine/threonine-protein kinase PFTAIRE-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:271697)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVR3;B7ZWG3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1901987 regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V3A1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZW0-1", "uniprot_id": [ { "id": "AT11C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZW0", "type": "external" } ], "mass": 129240.0, "length": 1129, "protein_name": "Phospholipid-transporting ATPase 11C", "gene_name": "Atp11c", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase 11C isoform a", "refseq_ac": [ { "id": "NP_001032952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032952", "type": "external" } ], "gene_names_uniprotkb": "Atp11c", "gene_names_refseq": "A330005H02Rik; Atp11c; Ig", "protein_names_uniprotkb": "Phospholipid-transporting ATPase 11C; 7.6.2.1; ATPase class VI type 11C; P4-ATPase flippase complex alpha subunit ATP11C", "protein_names_refseq": "Atpase 11c, p type; P4-ATPase flippase complex alpha subunit ATP11C; phospholipid-transporting ATPase 11C isoform a; probable phospholipid-transporting ATPase 11C", "tax_id": 10090, "disease": "X-linked congenital hemolytic anemia (Disease Ontology:DOID:0111846)", "pathway": " (mmu:320940); (R-MMU-936837)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11015572;21423172;21423173;21518881;21750661;24898253;24904167;25428506;26495903;26799398;30018401;30084848;31219806;34428180;36753036", "class_list": "", "function": "A defect is ATP11C results inlower B-cell phosphatidylserine flippase activity and disrupts B-cell development and antibody production and also causes hepatocellular carcinoma., [RefSeq, PubMed]; ATP11C is redundant during B cell development in the fetal liver but essential in the context of adult bone marrow where it is required for optiml responses to IL-7 and sustained expression of Ebf1., [RefSeq, PubMed]; ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation., [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24898253, PubMed:24904167, PubMed:26799398, PubMed:30018401). Major PS-flippase in immune cell subsets (PubMed:30018401). In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:24898253). Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate PS flipping in pro-B cells (PubMed:21423172, PubMed:26799398). May be involved in the transport of cholestatic bile acids (PubMed:21518881)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQR4", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0002329 pre-B cell differentiation;GO:0045579 positive regulation of B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QZW0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JY9-1", "uniprot_id": [ { "id": "ARP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JY9", "type": "external" } ], "mass": 47357.0, "length": 418, "protein_name": "Actin-related protein 3", "gene_name": "Actr3", "organism": "Mouse", "refseq_name": "actin-related protein 3", "refseq_ac": [ { "id": "NP_001192314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192314", "type": "external" } ], "gene_names_uniprotkb": "Actr3; Arp3", "gene_names_refseq": "1200003A09Rik; Actr3; Arp3", "protein_names_uniprotkb": "Actin-related protein 3; Actin-like protein 3", "protein_names_refseq": "ARP3 actin-related protein 3 homolog; actin-like protein 3; actin-related protein 3", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); opisthorchiasis (Disease Ontology:DOID:13768); glioblastoma (Disease Ontology:DOID:3068); gallbladder carcinoma (Disease Ontology:DOID:4948); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:74117); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12589062;17114649;20693329;21750661;23806337;25428506;26495903;30084848;34428180;35658973;37453647;39627609;40684658", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis., [UniProtKB, UniProtKB]; Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification., [RefSeq, PubMed]; Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC56", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0061851 leading edge of lamellipodium;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99JY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WE6-1", "uniprot_id": [ { "id": "CDKAL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WE6", "type": "external" } ], "mass": 65289.0, "length": 578, "protein_name": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "gene_name": "Cdkal1", "organism": "Mouse", "refseq_name": "threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2", "refseq_ac": [ { "id": "NP_001295415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295415", "type": "external" } ], "gene_names_uniprotkb": "Cdkal1", "gene_names_refseq": "1190005B03Rik; 6620401C13Rik; Cdkal1", "protein_names_uniprotkb": "Threonylcarbamoyladenosine tRNA methylthiotransferase; 2.8.4.5; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase", "protein_names_refseq": "tRNA-t(6)A37 methylthiotransferase; threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2; threonylcarbamoyladenosine tRNA methylthiotransferase", "tax_id": 10090, "disease": "gestational diabetes (Disease Ontology:DOID:11714); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:68916)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20584901;21750661;23048041;29031721;31941883;34428180;37245423", "class_list": "", "function": "Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine., [UniProtKB, PubMed]; Cdkal1 catalyzes methylthiolation of t6A37 in tRNALysUUU to ms2t6A37. Publication Status: Online-Only, [RefSeq, PubMed]; Cdkal1 is necessary for normal mitochondrial morphology and function in adipose tissue. These results suggest that the type 2 diabetes susceptibility gene CDKAL1 has novel functions in regulating mitochondrial activity., [RefSeq, PubMed]; Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE97;Q3V3D2;Q5T0I5;Q8C4B0;Q9CT69", "ec_number_list": [ { "id": "2.8.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.4.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0035598 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity;GO:0016740 transferase activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990145 maintenance of translational fidelity;GO:0035600 tRNA methylthiolation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WE6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR68-1", "uniprot_id": [ { "id": "CE112_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5PR68", "type": "external" } ], "mass": 112676.0, "length": 954, "protein_name": "Centrosomal protein of 112 kDa", "gene_name": "Cep112", "organism": "Mouse", "refseq_name": "centrosomal protein of 112 kDa isoform 1", "refseq_ac": [ { "id": "NP_083862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083862", "type": "external" } ], "gene_names_uniprotkb": "Cep112; Ccdc46", "gene_names_refseq": "1700001M19Rik; 1700029K01Rik; 8430407H02Rik; Ccdc46; Cep112; Macoco", "protein_names_uniprotkb": "Centrosomal protein of 112 kDa; Cep112; Coiled-coil domain-containing protein 46", "protein_names_refseq": "centrosomal protein of 112 kDa isoform 1; centrosomal protein of 112 kDa; coiled-coil domain containing 46; coiled-coil domain-containing protein 46", "tax_id": 10090, "disease": "spermatogenic failure 44 (Disease Ontology:DOID:0112109)", "pathway": " (mmu:76380)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11544199;21750661;25428506;39349455", "class_list": "", "function": "Recruits mRNAs essential for sperm development, such as CFAP61 and FSIP2 mRNAs, into phase-separated condensates, thereby regulating their translation through a mechanism of liquid-liquid phase separation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZN6;Q99JS4;Q9D9T1", "ec_number_list": [], "go_molecular_function": "GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005814 centriole;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0097120 receptor localization to synapse;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PR68-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R146-1", "uniprot_id": [ { "id": "ACPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R146", "type": "external" } ], "mass": 81581.0, "length": 732, "protein_name": "Acylamino-acid-releasing enzyme", "gene_name": "Apeh", "organism": "Mouse", "refseq_name": "acylamino-acid-releasing enzyme isoform 1", "refseq_ac": [ { "id": "NP_666338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666338", "type": "external" } ], "gene_names_uniprotkb": "Apeh", "gene_names_refseq": "Apeh", "protein_names_uniprotkb": "Acylamino-acid-releasing enzyme; 3.4.19.1; AARE; APH; Acyl-peptide hydrolase; Acylaminoacyl-peptidase", "protein_names_refseq": "AARE; APH; N-acylaminoacyl peptide hydrolase; acyl-peptide hydrolase; acylamino-acid-releasing enzyme isoform 1; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:235606); (R-MMU-6798695); (R-MMU-72764)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;26495903;26740625;28011936;34508712", "class_list": "glycogene", "function": "Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products., [RefSeq, PubMed]; Aminopeptidase involved in the degradation of N(alpha)-acylated peptides. Displays exopeptidase activity toward N-formyl and N-acetyl peptides with a preference for dipeptide substrates (By similarity). Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Hydrolyzes N-formylated peptides likely arising from N-terminal proteolytic cleavage of bacterial and mitochondrial proteins. May act sequentially with ACY1 in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate (By similarity). Displays endopeptidase activity involved in the degradation of oxidized and glycated proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9I2;Q8K029;Q8R0M9", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008242 omega peptidase activity;GO:0042802 identical protein binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R146-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDI6-1", "uniprot_id": [ { "id": "CD158_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDI6", "type": "external" } ], "mass": 126826.0, "length": 1109, "protein_name": "Coiled-coil domain-containing protein 158", "gene_name": "Ccdc158", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 158 isoform b", "refseq_ac": [ { "id": "NP_796204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796204", "type": "external" } ], "gene_names_uniprotkb": "Ccdc158", "gene_names_refseq": "4932413O14Rik; Ccdc158", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 158", "protein_names_refseq": "coiled-coil domain-containing protein 158 isoform b; coiled-coil domain-containing protein 158", "tax_id": 10090, "disease": "", "pathway": " (mmu:320696)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34418053;34428180", "class_list": "", "function": "Plays a role in receptor-mediated endocytosis in proximal tubular cells of the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU97", "ec_number_list": [], "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CDI6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7Q1-1", "uniprot_id": [ { "id": "DRC12_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C7Q1", "type": "external" } ], "mass": 23394.0, "length": 202, "protein_name": "Dynein regulatory complex protein 12", "gene_name": "Ccdc153; Drc12", "organism": "Mouse", "refseq_name": "dynein regulatory complex protein 12 isoform 1", "refseq_ac": [ { "id": "NP_001074838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074838", "type": "external" } ], "gene_names_uniprotkb": "Ccdc153; Drc12; Ccdc153", "gene_names_refseq": "Ccdc153; Drc12", "protein_names_uniprotkb": "Dynein regulatory complex protein 12", "protein_names_refseq": "coiled-coil domain containing 153; coiled-coil domain-containing protein 153; dynein regulatory complex protein 12 isoform 1; dynein regulatory complex protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:270150)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C7Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLK4-1", "uniprot_id": [ { "id": "CABP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLK4", "type": "external" } ], "mass": 24223.0, "length": 216, "protein_name": "Calcium-binding protein 2", "gene_name": "Cabp2", "organism": "Mouse", "refseq_name": "calcium-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001153724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153724", "type": "external" } ], "gene_names_uniprotkb": "Cabp2", "gene_names_refseq": "Cabp2", "protein_names_uniprotkb": "Calcium-binding protein 2; CaBP2", "protein_names_refseq": "calcium-binding protein 2 isoform 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 93 (Disease Ontology:DOID:0110537)", "pathway": " (mmu:29866)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10625670;17947313;21750661;26809054;27822497;28183797;29661613", "class_list": "", "function": "CaBP1 and CaBP2 are required for the normal function of the peripheral auditory system., [RefSeq, PubMed]; CaBP2 inhibits CaV1.3 Ca(2+)-channel inactivation., [RefSeq, PubMed]; Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (PubMed:27822497)., [UniProtKB, PubMed, PubMed]; Results show that CaBP1/caldendrin and CaBP2 are not required for normal gross retinal and synapse morphology but are necessary for the proper transmission of light responses through the retina; CaBP1/caldendrin and CaBP2 likely act by modulating presynaptic Ca(2+)-dependent signaling mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNX9;Q9JLK5", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JLK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810U5-1", "uniprot_id": [ { "id": "CCD50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810U5", "type": "external" } ], "mass": 35321.0, "length": 305, "protein_name": "Coiled-coil domain-containing protein 50", "gene_name": "Ccdc50", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 50 isoform 2", "refseq_ac": [ { "id": "NP_001020786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020786", "type": "external" } ], "gene_names_uniprotkb": "Ccdc50", "gene_names_refseq": "C3orf6; Ccdc50", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 50; Protein Ymer", "protein_names_refseq": "coiled-coil domain-containing protein 50 isoform 2; protein Ymer", "tax_id": 10090, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); autosomal dominant nonsyndromic deafness 44 (Disease Ontology:DOID:0110569)", "pathway": " (mmu:67501)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14527723;17503326;21750661;23418353;26495903;26740625;33277610;34428180;34453126;35620989;37165931", "class_list": "", "function": "Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases. Erratum:[Cell Mol Immunol. 2021 Dec;18(12):2682. doi: 10.1038/s41423-021-00777-7. PMID: 34654907], [RefSeq, PubMed]; Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth. Publication Status: Online-Only, [RefSeq, PubMed]; Insights into the pathophysiology of DFNA44 hearing loss associated with CCDC50 frameshift variants., [RefSeq, PubMed]; Involved in EGFR signaling., [UniProtKB]; The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6X929;Q3TRW1;Q8BP82;Q9CZT1;Q9D436", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q810U5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB75-1", "uniprot_id": [ { "id": "CDIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB75", "type": "external" } ], "mass": 21835.0, "length": 208, "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "Cdip1", "organism": "Mouse", "refseq_name": "cell death-inducing p53-target protein 1 isoform 4", "refseq_ac": [ { "id": "NP_079946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079946", "type": "external" } ], "gene_names_uniprotkb": "Cdip1; 5730403B10Rik", "gene_names_refseq": "2700048O17Rik; 5730403B10Rik; CDIP; Cdip1", "protein_names_uniprotkb": "Cell death-inducing p53-target protein 1; LITAF-like protein", "protein_names_refseq": "LITAF-like protein; cell death-inducing p53-target protein 1 isoform 4; cell death-inducing p53-target protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66626)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;24139803;30613267;31219806;32544461", "class_list": "", "function": "Acts as an important p53/TP53-apoptotic effector. Regulates TNF-mediated apoptosis in a p53/TP53-dependent manner (By similarity)., [UniProtKB, UniProtKB]; CDIP1 Promotes Bax Oligomerization and Mitochondrial Translocation during endoplasmic reticulum Stress., [RefSeq, PubMed]; Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors., [RefSeq, PubMed]; These findings reveal a novel regulatory pathway that comprises circular transcript of NCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis during ischemic cardiac disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD73;Q9CYP1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0098560 cytoplasmic side of late endosome membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DB75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70337-1", "uniprot_id": [ { "id": "BIK_MOUSE", "url": "https://www.uniprot.org/uniprot/O70337", "type": "external" } ], "mass": 16901.0, "length": 150, "protein_name": "Bcl-2-interacting killer", "gene_name": "Bik", "organism": "Mouse", "refseq_name": "bcl-2-interacting killer", "refseq_ac": [ { "id": "NP_031572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031572", "type": "external" } ], "gene_names_uniprotkb": "Bik; Biklk; Blk; Nbk", "gene_names_refseq": "Biklk; Bik; Blk; Nbk", "protein_names_uniprotkb": "Bcl-2-interacting killer; Apoptosis inducer NBK; Bik-like killer protein", "protein_names_refseq": "apoptosis inducer NBK; bcl-2-interacting killer; bik-like killer protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); ataxia telangiectasia (Disease Ontology:DOID:12704); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:12124)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11714762;21750661;36603764;37095508;38113109;38357926;9525867", "class_list": "", "function": "Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity., [UniProtKB, PubMed]; Bik promotes proteasomal degradation to control low-grade inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis., [RefSeq, PubMed]; Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins., [RefSeq, PubMed]; Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice. Erratum:[Virol J. 2023 May 15;20(1):95. doi: 10.1186/s12985-023-02060-9. PMID: 37189161] Publication Status: Online-Only, [RefSeq, PubMed]; Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0051400 BH domain binding", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0031966 mitochondrial membrane;GO:0012505 endomembrane system;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008584 male gonad development;GO:0031334 positive regulation of protein-containing complex assembly;GO:0042981 regulation of apoptotic process;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70337-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61735-1", "uniprot_id": [ { "id": "CD47_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61735", "type": "external" } ], "mass": 33098.0, "length": 303, "protein_name": "Leukocyte surface antigen CD47", "gene_name": "Cd47", "organism": "Mouse", "refseq_name": "leukocyte surface antigen CD47 isoform 4 precursor", "refseq_ac": [ { "id": "NP_034711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034711", "type": "external" } ], "gene_names_uniprotkb": "Cd47", "gene_names_refseq": "9130415E20Rik; B430305P08Rik; Cd47; IAP; Itgp", "protein_names_uniprotkb": "Leukocyte surface antigen CD47; IAP; Integrin-associated protein", "protein_names_refseq": "Rh-related antigen; integrin-associated protein; leukocyte surface antigen CD47 isoform 4 precursor; leukocyte surface antigen CD47", "tax_id": 10090, "disease": "", "pathway": " (mmu:16423); (R-MMU-202733); (R-MMU-216083); (R-MMU-391160); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10856220;15917238;18156939;20610415;21750661;23591719;27742621;30899004;32679764;33300544;7691831;9504415", "class_list": "", "function": "Adhesive protein that mediates cell-to-cell interactions (By similarity). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:20610415, PubMed:23591719, PubMed:27742621). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (PubMed:18156939). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (PubMed:10856220)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 31, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q921Z2", "ec_number_list": [], "go_molecular_function": "GO:0070053 thrombospondin receptor activity;GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion;GO:0070051 fibrinogen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0098793 presynapse", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q61735-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFQ8-1", "uniprot_id": [ { "id": "CARL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFQ8", "type": "external" } ], "mass": 150416.0, "length": 1375, "protein_name": "Capping protein, Arp2/3 and myosin-I linker protein 3", "gene_name": "Carmil3", "organism": "Mouse", "refseq_name": "capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001019816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019816", "type": "external" } ], "gene_names_uniprotkb": "Carmil3; Lrrc16b", "gene_names_refseq": "Carmil3; Lrrc16b; mFLJ00240", "protein_names_uniprotkb": "Capping protein, Arp2/3 and myosin-I linker protein 3; Capping protein regulator and myosin 1 linker protein 3; Leucine-rich repeat-containing protein 16B", "protein_names_refseq": "capping protein regulator and myosin 1 linker protein 3; capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1; capping protein, Arp2/3 and myosin-I linker protein 3; leucine-rich repeat-containing protein 16B", "tax_id": 10090, "disease": "", "pathway": " (mmu:268747)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAP3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0098794 postsynapse", "go_biological_process": "GO:0016477 cell migration;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UFQ8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7V8-1", "uniprot_id": [ { "id": "CC134_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7V8", "type": "external" } ], "mass": 26495.0, "length": 229, "protein_name": "Coiled-coil domain-containing protein 134", "gene_name": "Ccdc134", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 134 isoform 2", "refseq_ac": [ { "id": "NP_001313517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313517", "type": "external" } ], "gene_names_uniprotkb": "Ccdc134", "gene_names_refseq": "2310042L06Rik; Ccdc134", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 134", "protein_names_refseq": "coiled-coil domain-containing protein 134 isoform 2; coiled-coil domain-containing protein 134", "tax_id": 10090, "disease": "osteogenesis imperfecta (Disease Ontology:DOID:12347)", "pathway": " (mmu:76457)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22645316;29115376;37234153", "class_list": "", "function": "CCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development., [UniProtKB, UniProtKB]; The present results suggest that Ccdc134 may have specific biological functions in regulating mouse embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3V9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:1990402 embryonic liver development;GO:0001525 angiogenesis;GO:0001890 placenta development;GO:0021587 cerebellum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C7V8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TQ03-1", "uniprot_id": [ { "id": "CIART_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TQ03", "type": "external" } ], "mass": 40408.0, "length": 375, "protein_name": "Circadian-associated transcriptional repressor", "gene_name": "Ciart", "organism": "Mouse", "refseq_name": "circadian-associated transcriptional repressor isoform 1", "refseq_ac": [ { "id": "NP_001028474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028474", "type": "external" } ], "gene_names_uniprotkb": "Ciart; Gm129", "gene_names_refseq": "Chrono; Ciart; Gm129", "protein_names_uniprotkb": "Circadian-associated transcriptional repressor; ChIP-derived repressor of network oscillator; Chrono; Computationally highlighted repressor of the network oscillator", "protein_names_refseq": "chIP-derived repressor of network oscillator; circadian-associated transcriptional repressor isoform 1; circadian-associated transcriptional repressor; computationally highlighted repressor of the network oscillator", "tax_id": 10090, "disease": "", "pathway": " (mmu:229599)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;24385426;24736997;24737000;31219806;34584158;34678516;40997131", "class_list": "", "function": "CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN. Publication Status: Online-Only, [RefSeq, PubMed]; CHRONO interferes with the ability of BMAL1 to recruit CBP, a bona fide histone acetylase and key transcriptional coactivator of the circadian clock. Publication Status: Online-Only, [RefSeq, PubMed]; Chrono binds to the regulatory region of clock genes and its occupancy oscillates in a circadian manner. Publication Status: Online-Only, [RefSeq, PubMed]; The GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK.BMAL1 activity as a transcriptional repressor., [RefSeq, PubMed]; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1B8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0070888 E-box binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045475 locomotor rhythm;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3TQ03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWF0-1", "uniprot_id": [ { "id": "CAF1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWF0", "type": "external" } ], "mass": 101936.0, "length": 911, "protein_name": "Chromatin assembly factor 1 subunit A", "gene_name": "Chaf1a", "organism": "Mouse", "refseq_name": "chromatin assembly factor 1 subunit A", "refseq_ac": [ { "id": "NP_038761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038761", "type": "external" } ], "gene_names_uniprotkb": "Chaf1a; Caip150", "gene_names_refseq": "CAF-1; Cac1p; Chaf1a; p150", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit A; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor I p150 subunit", "protein_names_refseq": "CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF-Ip150; chromatin assembly factor 1 subunit A; chromatin assembly factor I p150 subunit", "tax_id": 10090, "disease": "colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); neuroblastoma (Disease Ontology:DOID:769); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:27221)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10549285;12697822;21750661;25153642;28135057;28528544;34365742;34887587;38051950;39627609", "class_list": "", "function": "Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci., [UniProtKB, UniProtKB]; CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming., [RefSeq, PubMed]; Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU22;Q544M2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070087 chromo shadow domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex;GO:0033186 CAF-1 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QWF0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3Q9-1", "uniprot_id": [ { "id": "CASP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3Q9", "type": "external" } ], "mass": 49979.0, "length": 454, "protein_name": "Caspase-9", "gene_name": "Casp9", "organism": "Mouse", "refseq_name": "caspase-9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_056548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056548", "type": "external" } ], "gene_names_uniprotkb": "Casp9; Mch6", "gene_names_refseq": "APAF-3; CASP-9; Casp9; Caspase-9; ICE-LAP6; Mch6", "protein_names_uniprotkb": "Caspase-9; 3.4.22.62; APAF-3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP-9; ICE-LAP6; ICE-like apoptotic protease 6", "protein_names_refseq": "ICE-like apoptotic protease 6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; caspase-9 isoform 1 precursor", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); endometritis (Disease Ontology:DOID:1002); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); varicocele (Disease Ontology:DOID:12337); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); severe acute respiratory syndrome (Disease Ontology:DOID:2945); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12371); (R-MMU-111458); (R-MMU-111459); (R-MMU-168638); (R-MMU-198323); (R-MMU-418889); (R-MMU-9627069)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "15657060;16888006;21750661;29187734;38056894", "class_list": "", "function": "Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.22.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.64", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.60", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "4.2.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.109", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043293 apoptosome", "go_biological_process": "GO:0071680 response to indole-3-methanol;GO:0002931 response to ischemia;GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C3Q9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49300-1", "uniprot_id": [ { "id": "CLC10_MOUSE", "url": "https://www.uniprot.org/uniprot/P49300", "type": "external" } ], "mass": 34596.0, "length": 304, "protein_name": "C-type lectin domain family 10 member A", "gene_name": "Clec10a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 10 member A isoform 2", "refseq_ac": [ { "id": "NP_034926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034926", "type": "external" } ], "gene_names_uniprotkb": "Clec10a; Mgl1; Mgl", "gene_names_refseq": "CD301a; Clec10a; M-ASGP-BP-1; Mgl1; Mgl", "protein_names_uniprotkb": "C-type lectin domain family 10 member A; M-ASGP-BP-1; Macrophage asialoglycoprotein-binding protein 1; Macrophage galactose-type lectin; Macrophage galactose/N-acetylgalactosamine-specific lectin; mMGL", "protein_names_refseq": "C-type lectin domain family 10 member A isoform 2; macrophage asialoglycoprotein-binding protein 1; macrophage galactose N-acetyl-galactosamine specific lectin 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17312)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10541808;12016228;15364954;1587794;19995956;21750661;25170304;3241002;33677516;36727518", "class_list": "glycogene", "function": "Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a., [RefSeq, PubMed]; MMGL1 preferentially binds Lewis X-conjugated soluble polyacrylamides, [RefSeq, PubMed]; Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report., [RefSeq, PubMed]; Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity (PubMed:19995956). Plays a role in resistance to Trypanosoma cruzi infection by ensuring optimal activation of macrophages (PubMed:25170304)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q549F6;Q91YT3", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0042806 fucose binding;GO:0038187 pattern recognition receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0002248 connective tissue replacement involved in inflammatory response wound healing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P49300-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV32-1", "uniprot_id": [ { "id": "ARC1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV32", "type": "external" } ], "mass": 41064.0, "length": 372, "protein_name": "Actin-related protein 2/3 complex subunit 1B", "gene_name": "Arpc1b", "organism": "Mouse", "refseq_name": "actin-related protein 2/3 complex subunit 1B", "refseq_ac": [ { "id": "NP_075631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075631", "type": "external" } ], "gene_names_uniprotkb": "Arpc1b", "gene_names_refseq": "41kDa; Arpc1b; L72; SOP2Hs; p41-ARC", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; p41-ARC", "protein_names_refseq": "actin-related protein 2/3 complex subunit 1B; arp2/3 complex 41 kDa subunit", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 71 (Disease Ontology:DOID:0112004); stomach cancer (Disease Ontology:DOID:10534); gastritis (Disease Ontology:DOID:4029); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:11867); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21750661;25605945;29187734;30084848;34428180;36382618;37507081;39927985", "class_list": "", "function": "Actin related protein 2/3 complex subunit 1 up-regulation in the hypothalamus prevents high-fat diet induced obesity., [RefSeq, PubMed]; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRC4", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005885 Arp2/3 protein complex;GO:0036284 tubulobulbar complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WV32-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGE6-1", "uniprot_id": [ { "id": "ATG4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGE6", "type": "external" } ], "mass": 44375.0, "length": 393, "protein_name": "Cysteine protease ATG4B", "gene_name": "Atg4b", "organism": "Mouse", "refseq_name": "cysteine protease ATG4B isoform 1", "refseq_ac": [ { "id": "NP_777363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777363", "type": "external" } ], "gene_names_uniprotkb": "Atg4b; Apg4b; Autl1; Kiaa0943", "gene_names_refseq": "2510009N07Rik; Apg4b; Atg4bl; Atg4b; Autl1; MmAPG4B", "protein_names_uniprotkb": "Cysteine protease ATG4B; 3.4.22.-; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; MmAPG4B", "protein_names_refseq": "APG4 (ATG4) autophagy-related homolog B; AUT-like 1, cysteine endopeptidase; autophagin 1; autophagy-related 4B; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; cysteine protease ATG4B isoform 1; cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:66615); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12446702;14530254;18768752;20577052;20634410;21551061;21750661;23093945;28135057;28528544;29458288;31219806;37434364;37952564;38050963;39305312", "class_list": "", "function": "ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1., [RefSeq, PubMed]; Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy., [RefSeq, PubMed]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:14530254, PubMed:20577052, PubMed:29458288). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (By similarity). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:14530254, PubMed:29458288). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:14530254, PubMed:29458288). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; FAT1 inhibits AML autophagy and proliferation via downregulating ATG4B expression., [RefSeq, PubMed]; TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; The Apg4B/autophagin-1 protease thus serves as a processing/deconjugating enzyme for these four highly divergent mammalian Apg8 homologues, GATE-16, MAP1-LC3, GABARAP, and Apg8L., [RefSeq, PubMed]; These results show that the lipidation of LC3 paralogues is involved in the completion of autophagosome formation in mammalian cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ22;Q8R098", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0097110 scaffold protein binding;GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BGE6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Y2-1", "uniprot_id": [ { "id": "B4GT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Y2", "type": "external" } ], "mass": 41909.0, "length": 369, "protein_name": "Beta-1,4-galactosyltransferase 2", "gene_name": "B4galt2", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 2 isoform 1", "refseq_ac": [ { "id": "NP_001240310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240310", "type": "external" } ], "gene_names_uniprotkb": "B4galt2", "gene_names_refseq": "B4galt2; Ggtb2; b4Gal-T2; beta4Gal-T2", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 2; 2.4.1.-; 2.4.1.22; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 2; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T2; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; b4Gal-T2", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; beta-1,4-GalTase 2; beta-1,4-galactosyltransferase 2 isoform 1; beta-1,4-galactosyltransferase 2; beta-1,4-galactosyltransferase II; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; lactose synthase A protein; nal synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:53418); (R-MMU-2022854); (R-MMU-975577)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;9597550", "class_list": "glycogene;glycosyltransferase", "function": "Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMP2", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0004461 lactose synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0005975 carbohydrate metabolic process;GO:0007420 brain development", "synthesized_glycan_count": 10444, "hit_score": 0.9, "record_id": "Q9Z2Y2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8L5-1", "uniprot_id": [ { "id": "CCD91_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8L5", "type": "external" } ], "mass": 50007.0, "length": 442, "protein_name": "Coiled-coil domain-containing protein 91", "gene_name": "Ccdc91", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 91 isoform 1", "refseq_ac": [ { "id": "NP_080187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080187", "type": "external" } ], "gene_names_uniprotkb": "Ccdc91; Ggabp", "gene_names_refseq": "1700086G08Rik; 1810060J02Rik; Ccdc91; p56", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 91; GGA-binding partner", "protein_names_refseq": "GGA-binding partner; coiled-coil domain-containing protein 91 isoform 1; coiled-coil domain-containing protein 91", "tax_id": 10090, "disease": "", "pathway": " (mmu:67015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3N8;Q9D9E8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0090160 Golgi to lysosome transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8L5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U155-1", "uniprot_id": [ { "id": "CC174_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U155", "type": "external" } ], "mass": 53942.0, "length": 467, "protein_name": "Coiled-coil domain-containing protein 174", "gene_name": "Ccdc174", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 174", "refseq_ac": [ { "id": "NP_766318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766318", "type": "external" } ], "gene_names_uniprotkb": "Ccdc174", "gene_names_refseq": "C130022K22Rik; Ccdc174", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 174", "protein_names_refseq": "coiled-coil domain-containing protein 174", "tax_id": 10090, "disease": "", "pathway": " (mmu:232236)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Probably involved in neuronal development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XC8;Q8CA20", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U155-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1D9-1", "uniprot_id": [ { "id": "CFA96_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1D9", "type": "external" } ], "mass": 35260.0, "length": 316, "protein_name": "Cilia-and flagella-associated protein 96", "gene_name": "Cfap96", "organism": "Mouse", "refseq_name": "cilia-and flagella-associated protein 96", "refseq_ac": [ { "id": "NP_001028320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028320", "type": "external" } ], "gene_names_uniprotkb": "Cfap96; 1700029J07Rik", "gene_names_refseq": "1700029J07Rik; Cfap96", "protein_names_uniprotkb": "Cilia-and flagella-associated protein 96", "protein_names_refseq": "UPF0602 protein C4orf47 homolog; cilia-and flagella-associated protein 96", "tax_id": 10090, "disease": "", "pathway": " (mmu:69479)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005881 cytoplasmic microtubule;GO:0097731 9+0 non-motile cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U1D9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810S2-1", "uniprot_id": [ { "id": "CB074_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810S2", "type": "external" } ], "mass": 22381.0, "length": 196, "protein_name": "Uncharacterized protein C2orf74 homolog", "gene_name": "1700093K21Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf74 homolog", "refseq_ac": [ { "id": "NP_001103603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103603", "type": "external" } ], "gene_names_uniprotkb": "1700093K21Rik", "gene_names_refseq": "1700093K21Rik; b2b3025Clo", "protein_names_uniprotkb": "Uncharacterized protein C2orf74 homolog", "protein_names_refseq": "uncharacterized protein C2orf74 homolog", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (mmu:67358)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24549580", "class_list": "", "function": "The 1700093K21Rik gene and flanking regions are correlated with reproductive isolation in the house mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9C4;Q9D9E2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q810S2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04735-1", "uniprot_id": [ { "id": "CDK16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04735", "type": "external" } ], "mass": 55914.0, "length": 496, "protein_name": "Cyclin-dependent kinase 16", "gene_name": "Cdk16", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 16 isoform 2", "refseq_ac": [ { "id": "NP_001297385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297385", "type": "external" } ], "gene_names_uniprotkb": "Cdk16; Crk5; Pctaire1; Pctk1", "gene_names_refseq": "Cdk16; Crk5; Pctaire1; Pctk1", "protein_names_uniprotkb": "Cyclin-dependent kinase 16; 2.7.11.22; CRK5; Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1", "protein_names_refseq": "PCTAIRE-motif protein kinase 1; cell division protein kinase 16; cyclin-dependent kinase 16 isoform 2; serine/threonine-protein kinase PCTAIRE-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18555)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12084709;12154078;1437147;16461345;21183079;21335063;22184064;22796189;22798068;24931367;26305884;31599954;8444355;9197417", "class_list": "", "function": "CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16. Erratum:[PLoS Genet. 2019 Mar 4;15(3):e1008021. doi: 10.1371/journal.pgen.1008021. PMID: 30830908] Publication Status: Online-Only, [RefSeq, PubMed]; Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis, [RefSeq, PubMed]; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0031175 neuron projection development;GO:0010508 positive regulation of autophagy;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q04735-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01882-1", "uniprot_id": [ { "id": "IGHDM_MOUSE", "url": "https://www.uniprot.org/uniprot/P01882", "type": "external" } ], "mass": 32353.0, "length": 290, "protein_name": "Ig delta chain C region membrane-bound form", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig delta chain C region membrane-bound form", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "29187734;6801528;6968091", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01882-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EST8-1", "uniprot_id": [ { "id": "IKBZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EST8", "type": "external" } ], "mass": 79007.0, "length": 728, "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "Nfkbiz", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor zeta isoform a", "refseq_ac": [ { "id": "NP_001152866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152866", "type": "external" } ], "gene_names_uniprotkb": "Nfkbiz; Inap; Mail", "gene_names_refseq": "INAP; Mail; Nfkbiz", "protein_names_uniprotkb": "NF-kappa-B inhibitor zeta; I-kappa-B-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; IkB-zeta; IkappaBzeta; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide", "protein_names_refseq": "I-kappa-B-zeta; IL-1 inducible nuclear ankyrin-repeat protein; IkappaB-zeta; NF-kappa-B inhibitor zeta isoform a; NF-kappa-B inhibitor zeta; ikB-zeta; ikappaBzeta; molecule possessing ankyrin-repeats induced by lipopolysaccharide", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:80859)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11086164;11278262;11356851;11797098;15241416;15618216;17447895;25107474;25282160;25428506;30084848;30779550;31219806;34428180;38918046", "class_list": "", "function": "Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Also seems to activate NF-kappa-B-mediated transcription (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (By similarity). Promotes transcription of LCN2 and DEFB4 (By similarity). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS (PubMed:11086164, PubMed:25107474). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (PubMed:11086164, PubMed:25107474). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; MAIL localizes in the nucleus, and accelerates IL-6 production by LPS stimulation in mouse fibroblasts., [RefSeq, PubMed]; Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVL7;Q3TWK9;Q3U8Y9;Q3UCI2;Q3URP0;Q3UW99;Q5NT97;Q99NA4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0070974 POU domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0098773 skin epidermis development;GO:0032980 keratinocyte activation;GO:2000321 positive regulation of T-helper 17 cell differentiation;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EST8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01872-1", "uniprot_id": [ { "id": "IGHM_MOUSE", "url": "https://www.uniprot.org/uniprot/P01872", "type": "external" } ], "mass": 49972.0, "length": 454, "protein_name": "Immunoglobulin heavy constant mu", "gene_name": "Ighm", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighm; Igh-6", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant mu; 55 kDa mu' chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "agammaglobulinemia 1 (Disease Ontology:DOID:0081136); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-MMU-5690714); (R-MMU-983695)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10899913;11062505;111247;12654314;1545868;1901381;21750661;23733956;2415657;28135254;29323348;30324136;30899004;31219806;34428180;34788614;36210013;37507081;6255422;6260591;6771019;6771020;6795090;6816276", "class_list": "", "function": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (By similarity). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (By similarity)., [UniProtKB, UniProtKB]; Constant region of membrane-bound IgM, part of the B cell receptor complex (BCR). IgM BCR provides constitutive tonic signaling for B cell survival. Mediates pre-BCR signaling that regulates B cell selection and rearrangement of Ig genes via allelic exclusion., [UniProtKB, PubMed, PubMed, PubMed]; Constant region of secreted IgM (sIgM), also known as the Fc region of IgM antibody. Able to multimerize, forms high order polymers, mainly pentamers and occasionally hexamers, providing for multivalency and high avidity recognition of antigens (By similarity). Natural sIgM are polyreactive and recognize conserved self- and pathogen-derived structures, whereas immune sIgM are secreted only upon exposure to pathogens and are antigen-specific. Both natural and immune sIgM are required for an efficient humoral immune response to infection (PubMed:10899913, PubMed:28135254, PubMed:34788614). Mediates sIgM effector functions mostly via Fc receptors and the complement system. On lymphoid cells binds high-affinity Fc receptor FCMR and promotes induction of an efficient neutralizing IgG response while maintaining tolerance to self-antigens. Recruits C1q complement component to initiate the classical complement pathway, facilitating the recognition and neutralization of pathogens by the host. Together with C1q and mannose-binding lectin promotes the phagocytosis of apoptotic cells by macrophages, ensuring the clearance of potential autoimmune epitopes from tissues (By similarity) (PubMed:10899913, PubMed:11062505, PubMed:28135254). Involved in mucosal immunity. It is transported by transcytosis across mucosal epithelium by PIGR and secreted on the apical side in complex with PIGR secretory component to scan mucosal lining for pathogens. IgM-antigen complexes undergo FCMR-mediated retrotranscytosis across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:34788614)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P01873", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0003823 antigen binding;GO:0042834 peptidoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0002637 regulation of immunoglobulin production;GO:0019731 antibacterial humoral response;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P01872-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES46-1", "uniprot_id": [ { "id": "PARVB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES46", "type": "external" } ], "mass": 41669.0, "length": 365, "protein_name": "Beta-parvin", "gene_name": "Parvb", "organism": "Mouse", "refseq_name": "beta-parvin", "refseq_ac": [ { "id": "NP_573395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573395", "type": "external" } ], "gene_names_uniprotkb": "Parvb", "gene_names_refseq": "D15Gsk1; Parvb; affixin", "protein_names_uniprotkb": "Beta-parvin", "protein_names_refseq": "beta-parvin", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:170736); (R-MMU-446343); (R-MMU-446353); (R-MMU-446388)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11171322;11722847;15835269;21750661;25428506;29567677;31599954;37507081", "class_list": "", "function": "Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity)., [UniProtKB]; Parvins are critical for the organization of endothelial cell-cell junctions, the establishment of endothelial apical-basal polarity, and the integrity of the basement membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0034446 substrate adhesion-dependent cell spreading;GO:0071963 establishment or maintenance of cell polarity regulating cell shape;GO:0030031 cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ES46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP73-1", "uniprot_id": [ { "id": "PD1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP73", "type": "external" } ], "mass": 32780.0, "length": 290, "protein_name": "Programmed cell death 1 ligand 1", "gene_name": "Cd274", "organism": "Mouse", "refseq_name": "programmed cell death 1 ligand 1 precursor", "refseq_ac": [ { "id": "NP_068693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068693", "type": "external" } ], "gene_names_uniprotkb": "Cd274; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1", "gene_names_refseq": "A530045L16Rik; B7h1; Cd274; Pdcd1l1; Pdcd1lg1; Pdl1", "protein_names_uniprotkb": "Programmed cell death 1 ligand 1; B7 homolog 1; B7-H1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1", "protein_names_refseq": "B7 homolog 1; PDCD1 ligand 1; programmed cell death 1 ligand 1 precursor; programmed cell death 1 ligand 1", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); infantile onset multisystem autoimmune disease 5 (Disease Ontology:DOID:0061164); Cryptococcal meningitis (Disease Ontology:DOID:0080159); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); toxic shock syndrome (Disease Ontology:DOID:14115); hepatitis C (Disease Ontology:DOID:1883); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); influenza (Disease Ontology:DOID:8469); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:60533); (R-MMU-389948); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9931295)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11015443;11224527;11238124;12218188;12719480;15030776;17911606;27281199;34428180", "class_list": "", "function": "B7-H1 regulates the accumulation and deletion of intrahepatic CD8(+) T cells which resulted in accelerated liver damage in experimental autoimmune hepatitis., [RefSeq, PubMed]; Interactions between PD-L1 and T regulatory cells regulate the maternal alloimmune response against paternal antigens on the fetus., [RefSeq, PubMed]; Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11238124). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11238124). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:11015443, PubMed:12719480)., [UniProtKB, PubMed, PubMed, PubMed]; The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:12218188, PubMed:27281199). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:12218188). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:12218188)., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 4, "disease_count": 16, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0015629 actin cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006955 immune response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EP73-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97762-1", "uniprot_id": [ { "id": "RP9_MOUSE", "url": "https://www.uniprot.org/uniprot/P97762", "type": "external" } ], "mass": 25262.0, "length": 213, "protein_name": "Retinitis pigmentosa 9 protein homolog", "gene_name": "Rp9; rp9", "organism": "Mouse", "refseq_name": "retinitis pigmentosa 9 protein homolog", "refseq_ac": [ { "id": "NP_061209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061209", "type": "external" } ], "gene_names_uniprotkb": "Rp9; rp9; Rp9h", "gene_names_refseq": "PAP-1; Rp9h; Rp9", "protein_names_uniprotkb": "Retinitis pigmentosa 9 protein homolog; PAP-1; Pim-1-associated protein", "protein_names_refseq": "Pim-1 associated protein; pim-1-associated protein; retinitis pigmentosa 9 homolog; retinitis pigmentosa 9 protein homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 9 (Disease Ontology:DOID:0110387)", "pathway": " (mmu:55934)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10931201;15556297;21750661;28216641;34428180", "class_list": "", "function": "Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1., [UniProtKB]; Rp9 gene knockout & point mutation knock in (Rp9, c.A386T, P.H129L) analogous to reported one in the retinitis pigmentosa patients (RP9, c.A410T, P.H137L) were studied. Proliferation and migration were significantly decreased in the mutated cells. Gene expression profiling by RNA-Seq demonstrated that retinitis pigmentosa associated genes, Fscn2 and Bbs2, were down-regulated in the mutated cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050890 cognition;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCD5-1", "uniprot_id": [ { "id": "TJAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCD5", "type": "external" } ], "mass": 60520.0, "length": 549, "protein_name": "Tight junction-associated protein 1", "gene_name": "Tjap1", "organism": "Mouse", "refseq_name": "tight junction-associated protein 1", "refseq_ac": [ { "id": "NP_001239402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239402", "type": "external" } ], "gene_names_uniprotkb": "Tjap1; Pilt; Tjp4", "gene_names_refseq": "0610041D19Rik; Pilt; Tjap1; Tjp4", "protein_names_uniprotkb": "Tight junction-associated protein 1; Protein incorporated later into tight junctions; Tight junction protein 4", "protein_names_refseq": "hdlg-binding protein Pilt; protein incorporated later into tight junctions; tight junction protein 4 (peripheral); tight junction-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74094)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11602598;19131326;21183079;21750661;22841714", "class_list": "", "function": "Plays a role in regulating the structure of the Golgi apparatus., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "I7H459;Q8CFL7;Q8R5I2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35566-1", "uniprot_id": [ { "id": "CD151_MOUSE", "url": "https://www.uniprot.org/uniprot/O35566", "type": "external" } ], "mass": 28246.0, "length": 253, "protein_name": "CD151 antigen", "gene_name": "Cd151", "organism": "Mouse", "refseq_name": "CD151 antigen", "refseq_ac": [ { "id": "NP_001104519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104519", "type": "external" } ], "gene_names_uniprotkb": "Cd151; Peta3", "gene_names_refseq": "Cd151; PETA-3; SFA-1; Tspan24", "protein_names_uniprotkb": "CD151 antigen; GP27; Membrane glycoprotein SFA-1; PETA-3; Platelet-endothelial tetraspan antigen 3", "protein_names_refseq": "CD151 antigen; GP27; membrane glycoprotein SFA-1; platelet-endothelial tetraspan antigen 3", "tax_id": 10090, "disease": "epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (mmu:12476); (R-MMU-446107)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12456024;12805567;15199151;16410781;17015618;21750661;31186138;31219806;31783316;34428180;37507081;9294006;9602068", "class_list": "", "function": "CD151 may be involved in the interaction of platelets with the subendothelial matrix at sites of vascular damage [review] Review article, [RefSeq, PubMed]; CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1, [RefSeq, PubMed]; Our study suggests that CD151 is a key player in the Wnt oncogene-driven tumorigenesis and impacts breast cancer malignancy in a cell type-dependent manner., [RefSeq, PubMed]; Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes., [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis (PubMed:15199151, PubMed:16410781). Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Essential for the proper assembly of the glomerular and tubular basement membranes in kidney (PubMed:17015618). Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89118", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005604 basement membrane", "go_biological_process": "GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0045807 positive regulation of endocytosis;GO:0044319 wound healing, spreading of cells;GO:0042098 T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35566-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K221-1", "uniprot_id": [ { "id": "ARFP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K221", "type": "external" } ], "mass": 37773.0, "length": 341, "protein_name": "Arfaptin-2", "gene_name": "Arfip2", "organism": "Mouse", "refseq_name": "arfaptin-2", "refseq_ac": [ { "id": "NP_084078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084078", "type": "external" } ], "gene_names_uniprotkb": "Arfip2", "gene_names_refseq": "2310002N04Rik; Arfip2; POR; Por1", "protein_names_uniprotkb": "Arfaptin-2; ADP-ribosylation factor-interacting protein 2", "protein_names_refseq": "ADP-ribosylation factor interacting protein 2; Arfaptin 2; arfaptin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76932); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25539497;25605945;31219806;34428180;36210013", "class_list": "", "function": "Highest level of Rac1 activation was achieved on the smallest nanofibers, a trend that was lost in POR1 knockdown. This supports the hypothesis that on small nanofibers, POR1 binds to highly curved cell membranes, allowing Rac1 to dissociate and activate., [RefSeq, PubMed]; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3G6;Q9D7M3", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0030742 GTP-dependent protein binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030036 actin cytoskeleton organization;GO:0034497 protein localization to phagophore assembly site;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K221-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47754-1", "uniprot_id": [ { "id": "CAZA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P47754", "type": "external" } ], "mass": 32967.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "Capza2", "organism": "Mouse", "refseq_name": "F-actin-capping protein subunit alpha-2", "refseq_ac": [ { "id": "NP_031630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031630", "type": "external" } ], "gene_names_uniprotkb": "Capza2; Cappa2", "gene_names_refseq": "1110053K06Rik; Cappa2; Capza2", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-2; CapZ alpha-2", "protein_names_refseq": "F-actin-capping protein subunit alpha-2; capZ alpha-2; capping protein (actin filament) muscle Z-line, alpha 2; capping protein alpha 2", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:12343); (R-MMU-879415)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21750661;25428506;25605945;26740625;30084848;32152506;33300544;34428180;37453647;39927985;9331217", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0016020 membrane;GO:0008290 F-actin capping protein complex;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47754-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08EC4-1", "uniprot_id": [ { "id": "CASS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08EC4", "type": "external" } ], "mass": 88621.0, "length": 804, "protein_name": "Cas scaffolding protein family member 4", "gene_name": "Cass4", "organism": "Mouse", "refseq_name": "cas scaffolding protein family member 4 isoform 2", "refseq_ac": [ { "id": "NP_001074289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074289", "type": "external" } ], "gene_names_uniprotkb": "Cass4", "gene_names_refseq": "Cass4; F730031O20Rik", "protein_names_uniprotkb": "Cas scaffolding protein family member 4", "protein_names_refseq": "cas scaffolding protein family member 4 isoform 2; likely orthologue of H. sapiens chromosome 20 open reading frame 32 (C20orf32)", "tax_id": 10090, "disease": "", "pathway": " (mmu:320664)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L397;Q08EC3;Q3TCH3", "ec_number_list": [], "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08EC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1U1-1", "uniprot_id": [ { "id": "CC171_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1U1", "type": "external" } ], "mass": 152309.0, "length": 1324, "protein_name": "Coiled-coil domain-containing protein 171", "gene_name": "Ccdc171", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 171 isoform 1", "refseq_ac": [ { "id": "NP_001342307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001342307", "type": "external" } ], "gene_names_uniprotkb": "Ccdc171; 4930473A06Rik", "gene_names_refseq": "4930418J05Rik; 4930473A06Rik; A330015D16Rik; Ccdc171", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 171", "protein_names_refseq": "coiled-coil domain-containing protein 171 isoform 1; coiled-coil domain-containing protein 171", "tax_id": 10090, "disease": "", "pathway": " (mmu:320226)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLX2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q1U1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULM0-1", "uniprot_id": [ { "id": "CC106_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULM0", "type": "external" } ], "mass": 32098.0, "length": 279, "protein_name": "Coiled-coil domain-containing protein 106", "gene_name": "Ccdc106", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 106 isoform a", "refseq_ac": [ { "id": "NP_001277358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277358", "type": "external" } ], "gene_names_uniprotkb": "Ccdc106; MNCb-2071", "gene_names_refseq": "Ccdc106", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 106", "protein_names_refseq": "coiled-coil domain-containing protein 106 isoform a; coiled-coil domain-containing protein 106", "tax_id": 10090, "disease": "", "pathway": " (mmu:232821)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Promotes the degradation of p53/TP53 protein and inhibits its transactivity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5E2;Q8VEI0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ULM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10598-1", "uniprot_id": [ { "id": "CASB_MOUSE", "url": "https://www.uniprot.org/uniprot/P10598", "type": "external" } ], "mass": 25337.0, "length": 231, "protein_name": "Beta-casein", "gene_name": "Csn2", "organism": "Mouse", "refseq_name": "beta-casein isoform b precursor", "refseq_ac": [ { "id": "NP_001272949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272949", "type": "external" } ], "gene_names_uniprotkb": "Csn2; Csnb", "gene_names_refseq": "Csn2; Csnb", "protein_names_uniprotkb": "Beta-casein", "protein_names_refseq": "beta-casein isoform b precursor; beta-casein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12991)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;2187188;2673924;27130254;27836773;3774558", "class_list": "", "function": "Dexamethasone signaling upregulates Claudin-3 and -4 without beta-casein expression. Prolactin and dexamethasone signaling synergistically upregulate beta-casein expression., [RefSeq, PubMed]; Important role in determination of the surface properties of the casein micelles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543D9;Q8VCT6;Q8VCU8;Q91VI5;Q922Y5;Q9D1U6;Q9D1U7", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10598-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31996-1", "uniprot_id": [ { "id": "CD68_MOUSE", "url": "https://www.uniprot.org/uniprot/P31996", "type": "external" } ], "mass": 34818.0, "length": 326, "protein_name": "Macrosialin", "gene_name": "Cd68", "organism": "Mouse", "refseq_name": "macrosialin precursor", "refseq_ac": [ { "id": "NP_001277987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277987", "type": "external" } ], "gene_names_uniprotkb": "Cd68", "gene_names_refseq": "Cd68; Lamp4; Scard1; gp110", "protein_names_uniprotkb": "Macrosialin", "protein_names_refseq": "macrosialin precursor; macrosialin", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); endometriosis of pelvic peritoneum (Disease Ontology:DOID:11429); primary biliary cholangitis (Disease Ontology:DOID:12236); diverticulitis of colon (Disease Ontology:DOID:13254); hepatitis B (Disease Ontology:DOID:2043); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); severe acute respiratory syndrome (Disease Ontology:DOID:2945); Merkel cell carcinoma (Disease Ontology:DOID:3965); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); Hodgkin's lymphoma (Disease Ontology:DOID:8567)", "pathway": " (mmu:12514); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10524236;16521125;21750661;25428506;31219806;39627609;8486654;9479000;9653646;9806844", "class_list": "", "function": "Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 14, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O54688;O70321;Q3S4A9;Q5F2A8;Q9DD15", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0002437 inflammatory response to antigenic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0031669 cellular response to nutrient levels;GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31996-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU05-1", "uniprot_id": [ { "id": "CE164_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU05", "type": "external" } ], "mass": 162601.0, "length": 1446, "protein_name": "Centrosomal protein of 164 kDa", "gene_name": "Cep164", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cep164; Kiaa1052", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 164 kDa; Cep164", "protein_names_refseq": "", "tax_id": 10090, "disease": "nephronophthisis 15 (Disease Ontology:DOID:0111123); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:214552); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "21750661;22863007;23955340;26337392;31219806;34428180", "class_list": "", "function": "Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYF9;Q6NZG6;Q8BQD2;Q8BSI0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0045177 apical part of cell", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5DU05-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40237-1", "uniprot_id": [ { "id": "CD82_MOUSE", "url": "https://www.uniprot.org/uniprot/P40237", "type": "external" } ], "mass": 29629.0, "length": 266, "protein_name": "CD82 antigen", "gene_name": "Cd82", "organism": "Mouse", "refseq_name": "CD82 antigen", "refseq_ac": [ { "id": "NP_001129527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129527", "type": "external" } ], "gene_names_uniprotkb": "Cd82; Kai1", "gene_names_refseq": "C33; Cd82; IA4; Kai1; Tspan27", "protein_names_uniprotkb": "CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1 homolog", "protein_names_refseq": "C33 antigen; CD82 antigen; inducible membrane protein R2; kangai 1 (suppression of tumorigenicity 6, prostate); metastasis suppressor Kangai-1 homolog", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (mmu:12521)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "19656770;21149584;21750661;26562164;31408613;33243288;34428180;34530889;34534447;35754722;36600050;8039242", "class_list": "", "function": "Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3., [RefSeq, PubMed]; KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity). Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (PubMed:31408613). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (PubMed:35754722). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (PubMed:21149584). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (PubMed:34530889)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Publication Status: Online-Only, [RefSeq, PubMed]; Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and progenitor cell mobilization., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045335 phagocytic vesicle;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40237-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXX9-1", "uniprot_id": [ { "id": "CC169_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXX9", "type": "external" } ], "mass": 24754.0, "length": 214, "protein_name": "Coiled-coil domain-containing protein 169", "gene_name": "Ccdc169", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 169 isoform b", "refseq_ac": [ { "id": "NP_001277067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277067", "type": "external" } ], "gene_names_uniprotkb": "Ccdc169; A730037C10Rik", "gene_names_refseq": "A730037C10Rik; Ccdc169", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 169", "protein_names_refseq": "coiled-coil domain-containing protein 169 isoform b; coiled-coil domain-containing protein 169", "tax_id": 10090, "disease": "", "pathway": " (mmu:320604)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVQ6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BXX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WT9-1", "uniprot_id": [ { "id": "CBS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WT9", "type": "external" } ], "mass": 61544.0, "length": 561, "protein_name": "Cystathionine beta-synthase", "gene_name": "Cbs", "organism": "Mouse", "refseq_name": "cystathionine beta-synthase isoform 2", "refseq_ac": [ { "id": "NP_001258282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258282", "type": "external" } ], "gene_names_uniprotkb": "Cbs", "gene_names_refseq": "Cbs; HIP4", "protein_names_uniprotkb": "Cystathionine beta-synthase; 4.2.1.22; Beta-thionase; Serine sulfhydrase", "protein_names_refseq": "beta-thionase; cystathionine beta-synthase isoform 2; serine sulfhydrase", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); neural tube defect (Disease Ontology:DOID:0080074); malaria (Disease Ontology:DOID:12365); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); homocystinuria (Disease Ontology:DOID:9263); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:12411); (R-MMU-1614603)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;34428180;38499142;38843767", "class_list": "", "function": "Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function., [RefSeq, PubMed]; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; KLF10/CBS increases the sensitivity of gastric carcinoma cells to methionine restriction by promoting sulfur transfer pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91WU3", "ec_number_list": [ { "id": "4.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.22", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0001974 blood vessel remodeling;GO:0071456 cellular response to hypoxia;GO:0097746 blood vessel diameter maintenance;GO:0042262 DNA protection", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WT9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920R0-1", "uniprot_id": [ { "id": "ALS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920R0", "type": "external" } ], "mass": 182566.0, "length": 1651, "protein_name": "Alsin", "gene_name": "Als2", "organism": "Mouse", "refseq_name": "alsin isoform 1", "refseq_ac": [ { "id": "NP_001153420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153420", "type": "external" } ], "gene_names_uniprotkb": "Als2", "gene_names_refseq": "3222402C23Rik; 9430073A21Rik; Als2cr6; Als2; Alsin; mKIAA1563", "protein_names_uniprotkb": "Alsin; Amyotrophic lateral sclerosis 2 protein homolog", "protein_names_refseq": "alsin isoform 1; amyotrophic lateral sclerosis 2 (juvenile) homolog; amyotrophic lateral sclerosis 2 protein homolog; amyotrophic lateral sclerosis protein 2 homolog", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 2 (Disease Ontology:DOID:0060194); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:74018); (R-MMU-8876198); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "11586298;15345747;17242355;21183079;21750661;22645316;22872234;22982304;23806337;25428506;25605945;26755825;27439389;30084848;31219806;33339852;34203471;34428180;34678516;35820727;40021952;40885482;40997131", "class_list": "", "function": "Alsin and spartin may interact each other physically., [RefSeq, PubMed]; By taking advantage of this CSMN reporter line of AlsinKO, authors reveal that apical dendrite degeneration is a common cellular pathology for CSMN that become diseased for different causes., [RefSeq, PubMed]; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons., [UniProtKB]; The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "G5E868;Q8JZR1;Q9CXJ3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005813 centrosome", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0007626 locomotory behavior;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q920R0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70295-1", "uniprot_id": [ { "id": "AUP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70295", "type": "external" } ], "mass": 46121.0, "length": 410, "protein_name": "Lipid droplet-regulating VLDL assembly factor AUP1", "gene_name": "Aup1", "organism": "Mouse", "refseq_name": "lipid droplet-regulating VLDL assembly factor AUP1 isoform 1", "refseq_ac": [ { "id": "NP_031543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031543", "type": "external" } ], "gene_names_uniprotkb": "Aup1", "gene_names_refseq": "Aup1", "protein_names_uniprotkb": "Lipid droplet-regulating VLDL assembly factor AUP1; Ancient ubiquitous protein 1", "protein_names_refseq": "lipid droplet-regulating VLDL assembly factor AUP1 isoform 1; lipid droplet-regulating VLDL assembly factor AUP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11993)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;8812468", "class_list": "", "function": "Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene contains several conserved domains including a hydrophobic domain, an acetyltransferase domain, a ubiquitin binding domain, and a domain required for recruitment of ubiquitin-conjugating enzyme E2 G2 (Ube2g2). In humans, this protein localizes to the endoplasmic reticulum and to lipid droplets. This protein is thought to be involved both in the degradation of misfolded proteins from the endoplasmic reticulum and in the storage of neutral lipids. Reduced expression of the human ortholog of this gene strongly reduces lipid droplet clustering in the cell, and causes stabilization of misfolded proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0009615 response to virus;GO:0036503 ERAD pathway;GO:0034389 lipid droplet organization;GO:0140042 lipid droplet formation;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70295-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YY2-1", "uniprot_id": [ { "id": "B4GT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YY2", "type": "external" } ], "mass": 44084.0, "length": 395, "protein_name": "Beta-1,4-galactosyltransferase 3", "gene_name": "B4galt3", "organism": "Mouse", "refseq_name": "beta-1,4-galactosyltransferase 3", "refseq_ac": [ { "id": "NP_065604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065604", "type": "external" } ], "gene_names_uniprotkb": "B4galt3", "gene_names_refseq": "9530061M23Rik; B4galt3; ESTM26; ESTM6", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 3; 2.4.1.-; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 3; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T3; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3; beta-1,4-GalTase 3; beta-1,4-galactosyltransferase 3; beta-1,4-galactosyltransferase III; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; beta4Gal-T3; beta4GalT-III; expressed sequence tag mouse EST 6; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:57370); (R-MMU-2022854); (R-MMU-975577)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;25428506;30899004;31219806;34428180;37901252;9597550", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY13", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006682 galactosylceramide biosynthetic process;GO:0006678 glucosylceramide metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 10105, "hit_score": 2.0, "record_id": "Q91YY2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TVC7-1", "uniprot_id": [ { "id": "CCDB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TVC7", "type": "external" } ], "mass": 39356.0, "length": 356, "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "organism": "Mouse", "refseq_name": "cyclin-D1-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_034891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034891", "type": "external" } ], "gene_names_uniprotkb": "Ccndbp1; Dip1; Gcip; Maid", "gene_names_refseq": "Ccndbp1; DIP1; GCIP; Maid; SECC-8; SSEC-8", "protein_names_uniprotkb": "Cyclin-D1-binding protein 1; Grap2 and cyclin-D-interacting protein; Maternal Id-like protein; SSEC-8; Stage specific embryonic cDNA-8 protein", "protein_names_refseq": "cyclin-D1-binding protein 1 isoform 1; cyclin-D1-binding protein 1; grap2 and cyclin-D-interacting protein; maternal Id-like protein; maternal inhibition of differentiation; stage specific embryonic cDNA-8 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:17151)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17256742;21750661;26002959;27235421;39256539;9186056", "class_list": "", "function": "Ccndbp1 is a positive modulator of skeletal myogenic differentiation in vivo and in vitro., [RefSeq, PubMed]; Data suggest Maid/Ccndbp1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); Maid does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis., [RefSeq, PubMed]; Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). May be required for hepatocyte proliferation., [UniProtKB, PubMed]; These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMI3;Q61162;Q99JA7;Q99KG4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TVC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UI66-1", "uniprot_id": [ { "id": "CCD34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UI66", "type": "external" } ], "mass": 42216.0, "length": 367, "protein_name": "Coiled-coil domain-containing protein 34", "gene_name": "Ccdc34", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 34 isoform a", "refseq_ac": [ { "id": "NP_080889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080889", "type": "external" } ], "gene_names_uniprotkb": "Ccdc34", "gene_names_refseq": "2810027O19Rik; 4930522P10Rik; Ccdc34", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 34", "protein_names_refseq": "coiled-coil domain-containing protein 34 isoform a; coiled-coil domain-containing protein 34", "tax_id": 10090, "disease": "spermatogenic failure 76 (Disease Ontology:DOID:0070575); spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (mmu:68201)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34348960", "class_list": "", "function": "Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS29;Q9CS41", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UI66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53569-1", "uniprot_id": [ { "id": "CEBPZ_MOUSE", "url": "https://www.uniprot.org/uniprot/P53569", "type": "external" } ], "mass": 120262.0, "length": 1052, "protein_name": "CCAAT/enhancer-binding protein zeta", "gene_name": "Cebpz", "organism": "Mouse", "refseq_name": "CCAAT/enhancer-binding protein zeta", "refseq_ac": [ { "id": "NP_001019977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019977", "type": "external" } ], "gene_names_uniprotkb": "Cebpz; Cbf2; Cebpa-rs1", "gene_names_refseq": "CBF2; Cbf; Cebpz", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein zeta; CBF; CCAAT-binding factor; CCAAT-box-binding transcription factor", "protein_names_refseq": "CCAAT-binding factor; CCAAT-box-binding transcription factor; CCAAT/enhancer-binding protein zeta", "tax_id": 10090, "disease": "", "pathway": " (mmu:12607)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;31219806;34428180;39627609;8604343", "class_list": "", "function": "Stimulates transcription from the HSP70 promoter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXW5;Q3TYA8;Q3UWQ7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53569-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KE7-1", "uniprot_id": [ { "id": "CCNL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KE7", "type": "external" } ], "mass": 60133.0, "length": 532, "protein_name": "Cyclin-L1", "gene_name": "Ccnl1", "organism": "Mouse", "refseq_name": "cyclin-L1 isoform 1", "refseq_ac": [ { "id": "NP_064321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064321", "type": "external" } ], "gene_names_uniprotkb": "Ccnl1; Ania6a; Ccn1", "gene_names_refseq": "2610030E23Rik; Ccnl1; Ccnl; ania-6a", "protein_names_uniprotkb": "Cyclin-L1; Cyclin Ania-6a; Cyclin-L", "protein_names_refseq": "cyclin ania-6a; cyclin-L1 isoform 1; cyclin-L", "tax_id": 10090, "disease": "", "pathway": " (mmu:56706)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11683997;17242355;17261272;18216018;19224205;20173027;21183079;21750661;21952136;25428507;25605945;30084848;30779550;31219806;34428180", "class_list": "", "function": "Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing. Inhibited by the CDK-specific inhibitor CDKN1A/p21., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ75;Q8R5H9;Q922K0;Q9CSZ3;Q9WV44", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q52KE7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4J0-1", "uniprot_id": [ { "id": "CCD60_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4J0", "type": "external" } ], "mass": 62969.0, "length": 545, "protein_name": "Coiled-coil domain-containing protein 60", "gene_name": "Ccdc60", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 60 isoform 1", "refseq_ac": [ { "id": "NP_808427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808427", "type": "external" } ], "gene_names_uniprotkb": "Ccdc60", "gene_names_refseq": "C130098D09; Ccdc60", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 60", "protein_names_refseq": "coiled-coil domain-containing protein 60 isoform 1; coiled-coil domain-containing protein 60", "tax_id": 10090, "disease": "", "pathway": " (mmu:269693)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX39;Q6DIA4;Q6PAQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C4J0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35495-1", "uniprot_id": [ { "id": "CDK14_MOUSE", "url": "https://www.uniprot.org/uniprot/O35495", "type": "external" } ], "mass": 52996.0, "length": 469, "protein_name": "Cyclin-dependent kinase 14", "gene_name": "Cdk14", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 14 isoform 1", "refseq_ac": [ { "id": "NP_035204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035204", "type": "external" } ], "gene_names_uniprotkb": "Cdk14; Kiaa0834; Pftk1", "gene_names_refseq": "Cdk14; Pftk1; mKIAA0834", "protein_names_uniprotkb": "Cyclin-dependent kinase 14; 2.7.11.22; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1", "protein_names_refseq": "cell division protein kinase 14; cyclin-dependent kinase 14 isoform 1; serine/threonine-protein kinase PFTAIRE-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18647)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;31219806;34203471;34428180;36103813;36210013;37907898;9202329;9547506", "class_list": "", "function": "CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression., [RefSeq, PubMed]; PFTK1 kinase regulates axogenesis during development via RhoA activation. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35848;Q3TNN9;Q3V319;Q6ZQ37", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:1901987 regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35495-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UJV1-1", "uniprot_id": [ { "id": "CCD61_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UJV1", "type": "external" } ], "mass": 57368.0, "length": 511, "protein_name": "Centrosomal protein CCDC61", "gene_name": "Ccdc61", "organism": "Mouse", "refseq_name": "centrosomal protein CCDC61 isoform 1", "refseq_ac": [ { "id": "NP_001028486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028486", "type": "external" } ], "gene_names_uniprotkb": "Ccdc61; Gm159; VFL3", "gene_names_refseq": "C530028I08Rik; Ccdc61; Gm159", "protein_names_uniprotkb": "Centrosomal protein CCDC61; Coiled-coil domain-containing protein 61; VFL3 homolog", "protein_names_refseq": "VFL3 homolog; centrosomal protein CCDC61 isoform 1; centrosomal protein CCDC61; coiled-coil domain-containing protein 61", "tax_id": 10090, "disease": "", "pathway": " (mmu:232933)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0030030 cell projection organization;GO:0098534 centriole assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UJV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97821-1", "uniprot_id": [ { "id": "CATC_MOUSE", "url": "https://www.uniprot.org/uniprot/P97821", "type": "external" } ], "mass": 52376.0, "length": 462, "protein_name": "Dipeptidyl peptidase 1", "gene_name": "Ctsc", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 1 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_034112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034112", "type": "external" } ], "gene_names_uniprotkb": "Ctsc", "gene_names_refseq": "CatC; Ctsc; DPP1; DPPI", "protein_names_uniprotkb": "Dipeptidyl peptidase 1; 3.4.14.1; Cathepsin C; Cathepsin J; DPP-I; DPPI; Dipeptidyl peptidase I exclusion domain chain; Dipeptidyl peptidase I heavy chain; Dipeptidyl peptidase I light chain; Dipeptidyl peptidase I; Dipeptidyl transferase", "protein_names_refseq": "cathepsin J; dipeptidyl peptidase 1 isoform 1 preproprotein; dipeptidyl peptidase 1; dipeptidyl peptidase I; dipeptidyl transferase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); brain ischemia (Disease Ontology:DOID:2316); Papillon-Lefevre disease (Disease Ontology:DOID:3389); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13032); (R-MMU-204005); (R-MMU-2132295); (R-MMU-5694530); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26495903;31219806;32152506;34171415;34428180;37453647;9099719;9130590", "class_list": "", "function": "Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion., [RefSeq, PubMed]; Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B., [UniProtKB, UniProtKB]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08853", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031404 chloride ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:1903980 positive regulation of microglial cell activation;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0051603 proteolysis involved in protein catabolic process;GO:1903052 positive regulation of proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P97821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4P0-1", "uniprot_id": [ { "id": "ARL5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4P0", "type": "external" } ], "mass": 20375.0, "length": 179, "protein_name": "ADP-ribosylation factor-like protein 5B", "gene_name": "Arl5b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arl5b; Arl8", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 5B; ADP-ribosylation factor-like protein 8", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:75869)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Binds and exchanges GTP and GDP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFU5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0K4-1", "uniprot_id": [ { "id": "CC137_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0K4", "type": "external" } ], "mass": 32918.0, "length": 290, "protein_name": "Coiled-coil domain-containing protein 137", "gene_name": "Ccdc137", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 137", "refseq_ac": [ { "id": "NP_690020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690020", "type": "external" } ], "gene_names_uniprotkb": "Ccdc137", "gene_names_refseq": "3110023B02Rik; Ccdc137", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 137", "protein_names_refseq": "coiled-coil domain-containing protein 137", "tax_id": 10090, "disease": "", "pathway": " (mmu:67291)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28528544;37542342", "class_list": "", "function": "RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization. Erratum:[J Exp Clin Cancer Res. 2025 Dec 26;44(1):325. doi: 10.1186/s13046-025-03612-3. PMID: 41454394] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0P6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R0K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86174-1", "uniprot_id": [ { "id": "BEND4_MOUSE", "url": "https://www.uniprot.org/uniprot/P86174", "type": "external" } ], "mass": 58721.0, "length": 541, "protein_name": "BEN domain-containing protein 4", "gene_name": "Bend4", "organism": "Mouse", "refseq_name": "BEN domain-containing protein 4", "refseq_ac": [ { "id": "NP_001158278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158278", "type": "external" } ], "gene_names_uniprotkb": "Bend4", "gene_names_refseq": "Bend4; D330027G24Rik; EG666938", "protein_names_uniprotkb": "BEN domain-containing protein 4", "protein_names_refseq": "BEN domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:666938)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P86174-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVN0-1", "uniprot_id": [ { "id": "CC122_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVN0", "type": "external" } ], "mass": 34235.0, "length": 290, "protein_name": "Coiled-coil domain-containing protein 122", "gene_name": "Ccdc122", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 122 isoform 2", "refseq_ac": [ { "id": "NP_001297577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297577", "type": "external" } ], "gene_names_uniprotkb": "Ccdc122", "gene_names_refseq": "4933415L06Rik; Ccdc122", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 122", "protein_names_refseq": "coiled-coil domain-containing protein 122 isoform 2; coiled-coil domain-containing protein 122", "tax_id": 10090, "disease": "", "pathway": " (mmu:108811)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSJ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56383-1", "uniprot_id": [ { "id": "AT5G2_MOUSE", "url": "https://www.uniprot.org/uniprot/P56383", "type": "external" } ], "mass": 15476.0, "length": 146, "protein_name": "ATP synthase F(0) complex subunit C2, mitochondrial", "gene_name": "Atp5mc2", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit C2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080744", "type": "external" } ], "gene_names_uniprotkb": "Atp5mc2; Atp5g2", "gene_names_refseq": "1810041M08Rik; Atp5g2; Atp5mc2", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 2; ATP synthase proteolipid P2; ATPase protein 9; ATPase subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C2, mitochondrial precursor; ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9); ATPase protein 9; ATPase subunit c", "tax_id": 10090, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143); urinary bladder cancer (Disease Ontology:DOID:11054); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:67942); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;28315936;30530489;31219806;34428180;35984892;36210013;36288343", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQM0;Q9CQ23", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0045471 response to ethanol;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P56383-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESK3-1", "uniprot_id": [ { "id": "CAN10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESK3", "type": "external" } ], "mass": 74596.0, "length": 666, "protein_name": "Calpain-10", "gene_name": "Capn10", "organism": "Mouse", "refseq_name": "calpain-10", "refseq_ac": [ { "id": "NP_035926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035926", "type": "external" } ], "gene_names_uniprotkb": "Capn10; Capn8", "gene_names_refseq": "Capn10; Capn8; mKIAA1845", "protein_names_uniprotkb": "Calpain-10; 3.4.22.-; CANP 10; Calcium-activated neutral proteinase 10", "protein_names_refseq": "CANP 10; calcium-activated neutral proteinase 10; calpain 8; calpain-10", "tax_id": 10090, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); pancreatic cancer (Disease Ontology:DOID:1793); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:23830); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11017071;20388922;21750661;25428506;30425305;32698137;38514708", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity)., [UniProtKB]; Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B Publication Status: Online-Only, [RefSeq, PubMed]; Capn10 plays an important role in regulating obesity and diabetes in mice., [RefSeq, PubMed]; Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6. Publication Status: Online-Only, [RefSeq, PubMed]; TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99J13;Q9WVF0", "ec_number_list": [ { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008092 cytoskeletal protein binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0032956 regulation of actin cytoskeleton organization;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDP6-1", "uniprot_id": [ { "id": "CDIPT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDP6", "type": "external" } ], "mass": 23599.0, "length": 213, "protein_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "gene_name": "Cdipt", "organism": "Mouse", "refseq_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1", "refseq_ac": [ { "id": "NP_080914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080914", "type": "external" } ], "gene_names_uniprotkb": "Cdipt; Pis1", "gene_names_refseq": "9530042F15Rik; Cdipt; D7Bwg0575e; Pis1; Pis", "protein_names_uniprotkb": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase; 2.7.8.11; PI synthase; Phosphatidylinositol synthase; PtdIns synthase", "protein_names_refseq": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1; PI synthase; phosphatidylinositol synthase; ptdIns synthase", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:52858); (R-MMU-1483226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20484733;21750661;30084848;33300544;34428180;40997131", "class_list": "", "function": "Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.11", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity;GO:0019992 diacylglycerol binding;GO:0043178 alcohol binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process;GO:0046341 CDP-diacylglycerol metabolic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VDP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TDU8-1", "uniprot_id": [ { "id": "DNAI7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6TDU8", "type": "external" } ], "mass": 84966.0, "length": 730, "protein_name": "Dynein axonemal intermediate chain 7", "gene_name": "Dnai7", "organism": "Mouse", "refseq_name": "dynein axonemal intermediate chain 7", "refseq_ac": [ { "id": "NP_796196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796196", "type": "external" } ], "gene_names_uniprotkb": "Dnai7; Casc1; Cfap94; Las1", "gene_names_refseq": "A230084G12Rik; Casc1; Cfap94; Dnai7; Las1", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 7; Cancer susceptibility candidate gene 1 protein homolog; Cilia and flagella associated protein 94; Lung adenoma susceptibility protein 1; Protein CASC1", "protein_names_refseq": "cancer susceptibility candidate 1; cancer susceptibility candidate gene 1 protein homolog; cancer susceptibility candidate protein 1; cilia and flagella associated protein 94; dynein axonemal intermediate chain 7; dynein intermediate chain CFAP94, axonemal; lung adenoma susceptibility 1; lung adenoma susceptibility protein 1; protein CASC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320662)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14583591;15064703;16862160;17974961;21750661;30060180", "class_list": "", "function": "Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor., [RefSeq, PubMed]; The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis., [RefSeq, PubMed]; Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (PubMed:30060180). May also act as a cell cycle regulator (PubMed:17974961)., [UniProtKB, PubMed, PubMed]; Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1). GeneRIF: Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0T6;Q64JA2;Q675B4;Q675B5;Q8BZM3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0051012 microtubule sliding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6TDU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62270-1", "uniprot_id": [ { "id": "RS18_MOUSE", "url": "https://www.uniprot.org/uniprot/P62270", "type": "external" } ], "mass": 17719.0, "length": 152, "protein_name": "Small ribosomal subunit protein uS13", "gene_name": "Rps18", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS13", "refseq_ac": [ { "id": "NP_035426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035426", "type": "external" } ], "gene_names_uniprotkb": "Rps18", "gene_names_refseq": "H-2Ke3; H2-Ke3; Ke-3; Rps18; ke3", "protein_names_uniprotkb": "Small ribosomal subunit protein uS13; 40S ribosomal protein S18; Ke-3; Ke3", "protein_names_refseq": "40S ribosomal protein S18; small ribosomal subunit protein uS13", "tax_id": 10090, "disease": "", "pathway": " (mmu:20084); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "1543907;21750661;22645316;25605945;34428180;35820727;36288343;36517592;37453647;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25232", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62270-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q6-1", "uniprot_id": [ { "id": "ARC1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q6", "type": "external" } ], "mass": 41626.0, "length": 370, "protein_name": "Actin-related protein 2/3 complex subunit 1A", "gene_name": "Arpc1a", "organism": "Mouse", "refseq_name": "actin-related protein 2/3 complex subunit 1A", "refseq_ac": [ { "id": "NP_062741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062741", "type": "external" } ], "gene_names_uniprotkb": "Arpc1a; Sid329", "gene_names_refseq": "0610010H08Rik; 1110030K07Rik; 41kDa; Arpc1a; Sid329; Sid32", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1A; SOP2-like protein; Sid 329", "protein_names_refseq": "SOP2-like protein; actin-related protein 2/3 complex subunit 1A; sid 329", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:56443); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;30084848;30899004;33300544;37507081", "class_list": "", "function": "Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL75", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0045202 synapse;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R0Q6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP26-1", "uniprot_id": [ { "id": "CALM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DP26", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-1", "gene_name": "Calm1; Calm2; Calm3", "organism": "Mouse", "refseq_name": "calmodulin-1 isoform 1", "refseq_ac": [ { "id": "NP_001300863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300863", "type": "external" } ], "gene_names_uniprotkb": "Calm1; Calm2; Calm3; Calm1; Calm; Cam1; Cam", "gene_names_refseq": "CaM; Calm1; Calm; Cam1", "protein_names_uniprotkb": "Calmodulin-1", "protein_names_refseq": "calmodulin-1 isoform 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); catecholaminergic polymorphic ventricular tachycardia 4 (Disease Ontology:DOID:0060678); long QT syndrome 14 (Disease Ontology:DOID:0110655); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12313); (mmu:12314); (mmu:12315); (R-MMU-111932); (R-MMU-111933); (R-MMU-111957); (R-MMU-114608); (R-MMU-1474151); (R-MMU-163615); (R-MMU-1855204); (R-MMU-2025928); (R-MMU-203615); (R-MMU-2514859); (R-MMU-2672351); (R-MMU-2871809); (R-MMU-4086398); (R-MMU-418359); (R-MMU-425561); (R-MMU-438066); (R-MMU-442729); (R-MMU-445355); (R-MMU-451308); (R-MMU-5218920); (R-MMU-5578775); (R-MMU-5607763); (R-MMU-5626467); (R-MMU-5627123); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-70221); (R-MMU-8876725); (R-MMU-9009391); (R-MMU-936837); (R-MMU-9619229); (R-MMU-9648002); (R-MMU-9856530)", "pathway_count": 36, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10620513;12106288;16569770;17151196;18034455;18650434;21183079;21750661;23806337;23942337;24569478;25380116;25428506;29025071;31088288;32152506;32848054;3384819;34358562;36417862;38635101", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (By similarity). Calcium-binding is required for the activation of calmodulin (By similarity). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). Is a regulator of voltage-dependent L-type calcium channels (By similarity). Mediates calcium-dependent inactivation of CACNA1C (By similarity). Positively regulates calcium-activated potassium channel activity of KCNN2 (By similarity). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (By similarity). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity). Component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex required to turn off the mitochondrial stress response after a specific stress event has been resolved (By similarity)., [UniProtKB, UniProtKB]; MiR-202-3p Targets Calm1 and Suppresses Inflammation in a Mouse Model of Acute Respiratory Distress Syndrome., [RefSeq, PubMed]; SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning., [RefSeq, PubMed]; This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62204;P70667;P99014;Q3TEH7;Q3THK5;Q3U6Z5;Q3U7C7;Q498A3;Q61379;Q61380;Q8BNC9;Q91VQ9;Q9D6G4", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P0DP26-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61022-1", "uniprot_id": [ { "id": "CHP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61022", "type": "external" } ], "mass": 22432.0, "length": 195, "protein_name": "Calcineurin B homologous protein 1", "gene_name": "Chp1", "organism": "Mouse", "refseq_name": "calcineurin B homologous protein 1", "refseq_ac": [ { "id": "NP_062743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062743", "type": "external" } ], "gene_names_uniprotkb": "Chp1; 1500003O03Rik; Chp; Sid470", "gene_names_refseq": "1500003O03Rik; Cahp; Chp1; Chp; Sid470p; p24; vac", "protein_names_uniprotkb": "Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22; Sid 470; p24", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein p22; calcineurin B homologous protein 1; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22; sid 470", "tax_id": 10090, "disease": "spastic ataxia (Disease Ontology:DOID:0050952)", "pathway": " (mmu:56398); (R-MMU-2160916)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;18815128;21750661;23904602;30084848;8967452", "class_list": "", "function": "CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway, [RefSeq, PubMed]; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membranes. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity)., [UniProtKB, UniProtKB]; This study demonistrated that CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62877;Q6ZWQ8", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity;GO:0061024 membrane organization;GO:0050821 protein stabilization;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P61022-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQG5-1", "uniprot_id": [ { "id": "BEAN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQG5", "type": "external" } ], "mass": 28538.0, "length": 255, "protein_name": "Protein BEAN1", "gene_name": "Bean1", "organism": "Mouse", "refseq_name": "protein BEAN1 isoform b", "refseq_ac": [ { "id": "NP_001135396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135396", "type": "external" } ], "gene_names_uniprotkb": "Bean1", "gene_names_refseq": "Bean1; Bean", "protein_names_uniprotkb": "Protein BEAN1; BEAN; Brain-expressed protein associating with Nedd4", "protein_names_refseq": "brain-expressed protein associating with Nedd4; protein BEAN1 isoform b; protein BEAN1; protein BEAN", "tax_id": 10090, "disease": "spinocerebellar ataxia 31 (Disease Ontology:DOID:0050980)", "pathway": " (mmu:65115)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11042109;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQG5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER56-1", "uniprot_id": [ { "id": "CAN12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER56", "type": "external" } ], "mass": 80588.0, "length": 720, "protein_name": "Calpain-12", "gene_name": "Capn12", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capn12", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-12; 3.4.22.-; CANP 12; Calcium-activated neutral proteinase 12", "protein_names_refseq": "", "tax_id": 10090, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:60594); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10964513;21750661", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER53;Q9ER54;Q9ER55", "ec_number_list": [ { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ER56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AQH4-1", "uniprot_id": [ { "id": "BCORL_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AQH4", "type": "external" } ], "mass": 190487.0, "length": 1781, "protein_name": "BCL-6 corepressor-like protein 1", "gene_name": "Bcorl1", "organism": "Mouse", "refseq_name": "BCL-6 corepressor-like protein 1", "refseq_ac": [ { "id": "NP_848897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848897", "type": "external" } ], "gene_names_uniprotkb": "Bcorl1", "gene_names_refseq": "6720425J07Rik; B930011H20Rik; Bcorl1", "protein_names_uniprotkb": "BCL-6 corepressor-like protein 1; BCoR-L1; BCoR-like protein 1", "protein_names_refseq": "BCL-6 corepressor-like protein 1; BCoR-L1; BCoR-like protein 1", "tax_id": 10090, "disease": "Shukla-Vernon syndrome (Disease Ontology:DOID:0111841); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:320376)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;25428506;29187734;31219806;32376790;32782141;34428180;34678516;36852467;40885482;40997131", "class_list": "", "function": "Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMH7;Q8BV26;Q8BW58", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "A2AQH4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YH5-1", "uniprot_id": [ { "id": "ATLA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YH5", "type": "external" } ], "mass": 60575.0, "length": 541, "protein_name": "Atlastin-3", "gene_name": "Atl3", "organism": "Mouse", "refseq_name": "atlastin-3 isoform 1", "refseq_ac": [ { "id": "NP_001156977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156977", "type": "external" } ], "gene_names_uniprotkb": "Atl3", "gene_names_refseq": "4633402C03Rik; 5730596K20Rik; ATL-3; Atl3", "protein_names_uniprotkb": "Atlastin-3; 3.6.5.-; ATL-3", "protein_names_refseq": "atlastin-3 isoform 1; atlastin-3", "tax_id": 10090, "disease": "hereditary sensory neuropathy type 1F (Disease Ontology:DOID:0070154); hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:109168)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26740625;27669642;28528544;32075961;34019998;34428180;37453647", "class_list": "", "function": "Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (By similarity). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy., [RefSeq, PubMed]; Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGW3;Q8C0L7;Q8C174;Q99LZ9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0071346 cellular response to type II interferon;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91YH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6D4-1", "uniprot_id": [ { "id": "BEND5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6D4", "type": "external" } ], "mass": 48227.0, "length": 421, "protein_name": "BEN domain-containing protein 5", "gene_name": "Bend5", "organism": "Mouse", "refseq_name": "BEN domain-containing protein 5", "refseq_ac": [ { "id": "NP_080555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080555", "type": "external" } ], "gene_names_uniprotkb": "Bend5", "gene_names_refseq": "2310026E23Rik; Bend5", "protein_names_uniprotkb": "BEN domain-containing protein 5", "protein_names_refseq": "BEN domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67621)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Acts as a transcriptional repressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJI2;Q80V74;Q80WB6;Q9CRW0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C6D4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFB2-1", "uniprot_id": [ { "id": "BCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFB2", "type": "external" } ], "mass": 52213.0, "length": 460, "protein_name": "Box C/D snoRNA protein 1", "gene_name": "Znhit6", "organism": "Mouse", "refseq_name": "box C/D snoRNA protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001074563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074563", "type": "external" } ], "gene_names_uniprotkb": "Znhit6; Bcd1", "gene_names_refseq": "2410019A14Rik; Znhit6", "protein_names_uniprotkb": "Box C/D snoRNA protein 1; Zinc finger HIT domain-containing protein 6", "protein_names_refseq": "box C/D snoRNA protein 1 isoform 1; box C/D snoRNA protein 1; zinc finger HIT domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:229937)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;22872234;31219806;34428180", "class_list": "", "function": "Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW16;Q3TG81", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0000492 box C/D snoRNP assembly;GO:0048254 snoRNA localization;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UFB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61457-1", "uniprot_id": [ { "id": "CCNE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61457", "type": "external" } ], "mass": 46986.0, "length": 408, "protein_name": "G1/S-specific cyclin-E1", "gene_name": "Ccne1", "organism": "Mouse", "refseq_name": "G1/S-specific cyclin-E1", "refseq_ac": [ { "id": "NP_031659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031659", "type": "external" } ], "gene_names_uniprotkb": "Ccne1; Ccne", "gene_names_refseq": "Ccne1; CycE1", "protein_names_uniprotkb": "G1/S-specific cyclin-E1", "protein_names_refseq": "G1/S-specific cyclin-E1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); breast adenocarcinoma (Disease Ontology:DOID:3458); liver cancer (Disease Ontology:DOID:3571); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:12447); (R-MMU-1538133); (R-MMU-187577); (R-MMU-2559586); (R-MMU-6804116); (R-MMU-69017); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69563); (R-MMU-8849470); (R-MMU-9706019)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "11585773;21750661;8003041", "class_list": "", "function": "Essential for the control of the cell cycle at the G1/S (start) transition., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05BA1;Q05BA6;Q05BB7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0051301 cell division;GO:0000723 telomere maintenance;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61457-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56212-1", "uniprot_id": [ { "id": "ARP19_MOUSE", "url": "https://www.uniprot.org/uniprot/P56212", "type": "external" } ], "mass": 12293.0, "length": 112, "protein_name": "cAMP-regulated phosphoprotein 19", "gene_name": "Arpp19", "organism": "Mouse", "refseq_name": "cAMP-regulated phosphoprotein 19 isoform 1", "refseq_ac": [ { "id": "NP_067523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067523", "type": "external" } ], "gene_names_uniprotkb": "Arpp19", "gene_names_refseq": "19kDa; 2700024H10Rik; ARPP-19; Arpp12; Arpp19", "protein_names_uniprotkb": "cAMP-regulated phosphoprotein 19; ARPP-19", "protein_names_refseq": "cAMP-regulated phosphoprotein 19 isoform 1; cAMP-regulated phosphoprotein ARPP-19; cyclic AMP phosphoprotein, 19 kDa; cyclic AMP phosphoprotein, 19kD", "tax_id": 10090, "disease": "", "pathway": " (mmu:59046); (R-MMU-2465910)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11279279;21183079;21750661;22617447;2845422;30626720;34428180;35820727", "class_list": "", "function": "ARPP-19 is validated by showing reduced mRNA and protein levels when miR-320 is overexpressed in neurites., [RefSeq, PubMed]; During mouse embryogenesis, the Arpp19 and Ensa paralog genes display specific functions by differentially controlling cell cycle progression., [RefSeq, PubMed]; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543L2", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015459 potassium channel regulator activity;GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045722 positive regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56212-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWU8-1", "uniprot_id": [ { "id": "AT2L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWU8", "type": "external" } ], "mass": 55496.0, "length": 499, "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "Etnppl", "organism": "Mouse", "refseq_name": "ethanolamine-phosphate phospho-lyase", "refseq_ac": [ { "id": "NP_001157059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157059", "type": "external" } ], "gene_names_uniprotkb": "Etnppl; Agxt2l1", "gene_names_refseq": "1300019H02Rik; Agxt2l1; Etnppl", "protein_names_uniprotkb": "Ethanolamine-phosphate phospho-lyase; 4.2.3.2; Alanine--glyoxylate aminotransferase 2-like 1", "protein_names_refseq": "alanine--glyoxylate aminotransferase 2-like 1; ethanolamine-phosphate phospho-lyase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71760); (R-MMU-1483213)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;30084848;34048714", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811K4;Q9DBB3", "ec_number_list": [ { "id": "4.2.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0050459 ethanolamine-phosphate phospho-lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0032094 response to food;GO:0006649 phospholipid transfer to membrane;GO:0071385 cellular response to glucocorticoid stimulus;GO:1905372 ceramide phosphoethanolamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BWU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D439-1", "uniprot_id": [ { "id": "CFA53_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D439", "type": "external" } ], "mass": 61911.0, "length": 514, "protein_name": "Cilia- and flagella-associated protein 53", "gene_name": "Cfap53", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 53", "refseq_ac": [ { "id": "NP_083224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083224", "type": "external" } ], "gene_names_uniprotkb": "Cfap53; Ccdc11", "gene_names_refseq": "4933415I03Rik; Ccdc11; Cfap53", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 53; Coiled-coil domain-containing protein 11", "protein_names_refseq": "cilia- and flagella-associated protein 53; coiled-coil domain containing 11; coiled-coil domain-containing protein 11", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 6 (Disease Ontology:DOID:0051020)", "pathway": " (mmu:74453)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;33347437;34124066;37295417;37865089;37989994", "class_list": "", "function": "CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (PubMed:33347437). Required for centriolar satellite integrity and non-motile cilium assembly (By similarity). Required for motile cilium formation (By similarity). Through its role in the beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:33347437). Required for sperm flagellum biogenesis and is essential for male fertility (PubMed:34124066)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KL15", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005576 extracellular region;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D439-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R045-1", "uniprot_id": [ { "id": "ANGL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R045", "type": "external" } ], "mass": 57105.0, "length": 493, "protein_name": "Angiopoietin-related protein 2", "gene_name": "Angptl2", "organism": "Mouse", "refseq_name": "angiopoietin-related protein 2 precursor", "refseq_ac": [ { "id": "NP_036053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036053", "type": "external" } ], "gene_names_uniprotkb": "Angptl2; Arp2", "gene_names_refseq": "Angptl2; Arp2", "protein_names_uniprotkb": "Angiopoietin-related protein 2; Angiopoietin-like protein 2", "protein_names_refseq": "angiopoietin-like protein 2; angiopoietin-related protein 2 precursor; angiopoietin-related protein 2", "tax_id": 10090, "disease": "dermatomyositis (Disease Ontology:DOID:10223)", "pathway": " (mmu:26360)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10473614;18514180;19553662;19723494;21750661;25428506;31219806;34428180;37452654;37531825;37736764;38758159", "class_list": "", "function": "ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway., [RefSeq, PubMed]; ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2., [RefSeq, PubMed]; ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. Publication Status: Online-Only, [RefSeq, PubMed]; ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion., [RefSeq, PubMed]; Angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in mice., [RefSeq, PubMed]; Data suggest that interaction of ANG2, a proangiogenic factor, with its receptor Tie2 promotes neural progenitor cell differentiation into neuronal lineage cells., [RefSeq, PubMed]; Induces sprouting in endothelial cells through an autocrine and paracrine action., [UniProtKB]; This work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM09", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R045-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D898-1", "uniprot_id": [ { "id": "ARP5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D898", "type": "external" } ], "mass": 16980.0, "length": 153, "protein_name": "Actin-related protein 2/3 complex subunit 5-like protein", "gene_name": "Arpc5l", "organism": "Mouse", "refseq_name": "actin-related protein 2/3 complex subunit 5-like protein isoform a", "refseq_ac": [ { "id": "NP_083085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083085", "type": "external" } ], "gene_names_uniprotkb": "Arpc5l", "gene_names_refseq": "2010015J01Rik; ARC16-2; Arpc5l", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 5-like protein; ARC16-2; Arp2/3 complex 16 kDa subunit 2", "protein_names_refseq": "actin-related protein 2/3 complex subunit 5-like protein isoform a; actin-related protein 2/3 complex subunit 5-like protein; arp2/3 complex 16 kDa subunit 2", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:74192)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16075062;21750661", "class_list": "", "function": "May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045202 synapse;GO:0030863 cortical cytoskeleton;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0016477 cell migration;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D898-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8S3-1", "uniprot_id": [ { "id": "ARFG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8S3", "type": "external" } ], "mass": 57456.0, "length": 523, "protein_name": "ADP-ribosylation factor GTPase-activating protein 3", "gene_name": "Arfgap3", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 3 isoform 3", "refseq_ac": [ { "id": "NP_079721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079721", "type": "external" } ], "gene_names_uniprotkb": "Arfgap3", "gene_names_refseq": "0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik; Arfgap1; Arfgap3", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3", "protein_names_refseq": "ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase-activating protein 3 isoform 3; ARF GAP 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66251); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-9013408)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "16452087;21183079;21750661;24719103;28528544;31219806;31989201", "class_list": "", "function": "ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent manner., [RefSeq, PubMed]; Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle., [RefSeq, PubMed]; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544V6;Q8BW06;Q99KN8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048786 presynaptic active zone;GO:0098684 photoreceptor ribbon synapse", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0009306 protein secretion;GO:0140238 presynaptic endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D8S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D504-1", "uniprot_id": [ { "id": "ANKR7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D504", "type": "external" } ], "mass": 31202.0, "length": 279, "protein_name": "Ankyrin repeat domain-containing protein 7", "gene_name": "Ankrd7", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001161229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161229", "type": "external" } ], "gene_names_uniprotkb": "Ankrd7", "gene_names_refseq": "4930532L20Rik; Ankrd7", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 7", "protein_names_refseq": "ankyrin repeat domain-containing protein 7 isoform 1; ankyrin repeat domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:75196)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810N2;Q8BVP4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ25-1", "uniprot_id": [ { "id": "ANKK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ25", "type": "external" } ], "mass": 82480.0, "length": 745, "protein_name": "Ankyrin repeat and protein kinase domain-containing protein 1", "gene_name": "Ankk1", "organism": "Mouse", "refseq_name": "ankyrin repeat and protein kinase domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_766510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766510", "type": "external" } ], "gene_names_uniprotkb": "Ankk1", "gene_names_refseq": "9930020N01Rik; Ankk1", "protein_names_uniprotkb": "Ankyrin repeat and protein kinase domain-containing protein 1; 2.7.11.1", "protein_names_refseq": "ankyrin repeat and protein kinase domain-containing protein 1 isoform 2; ankyrin repeat and protein kinase domain-containing protein 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); alexithymia (Disease Ontology:DOID:0060131); mild cognitive impairment (Disease Ontology:DOID:0080832); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); alcohol-induced mental disorder (Disease Ontology:DOID:251); opiate dependence (Disease Ontology:DOID:2559); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:244859)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29758057;30016717", "class_list": "", "function": "Study characterized the ANKK1 localization in vivo and in vitro, by using immunolabeling, quantitative real-time PCR and Western blot in the myogenic lineage. Histologic investigations in mice and humans revealed that ANKK1 is expressed in precursors of embryonic and adult muscles. Results show a relationship between ANKK1 gene regulation and the metabolism of muscles during development and in adulthood. Erratum:[PLoS One. 2018 Jun 6;13(6):e0198880. doi: 10.1371/journal.pone.0198880. PMID: 29874274] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042995 cell projection", "go_biological_process": "GO:0071300 cellular response to retinoic acid;GO:0010564 regulation of cell cycle process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BZ25-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVL1-1", "uniprot_id": [ { "id": "AP4S1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVL1", "type": "external" } ], "mass": 16818.0, "length": 144, "protein_name": "AP-4 complex subunit sigma-1", "gene_name": "Ap4s1", "organism": "Mouse", "refseq_name": "AP-4 complex subunit sigma-1 isoform 2", "refseq_ac": [ { "id": "NP_068356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068356", "type": "external" } ], "gene_names_uniprotkb": "Ap4s1", "gene_names_refseq": "Ap4s1", "protein_names_uniprotkb": "AP-4 complex subunit sigma-1; AP-4 adaptor complex subunit sigma-1; Adaptor-related protein complex 4 subunit sigma-1; Sigma-1 subunit of AP-4; Sigma-4-adaptin; Sigma4-adaptin", "protein_names_refseq": "AP-4 adapter complex subunit sigma-1; AP-4 complex subunit sigma-1 isoform 2; adapter-related protein complex 4 subunit sigma-1; sigma4-adaptin", "tax_id": 10090, "disease": "hereditary spastic paraplegia 52 (Disease Ontology:DOID:0110804)", "pathway": " (mmu:11782); (R-MMU-432720)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10066790;21750661;25428506;25605945;30084848;34428180", "class_list": "", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the sigma subunit of the adaptor-related protein complex 4 which mediates intracellular membrane trafficking along the endocytic and secretory transport pathways. This complex contains four subunits, beta, epsilon, mu, and sigma, and belongs to a family of five adapter protein complexes, including three clathrin-associated complexes and two non clathrin-associated complexes, that localize to different intracellular compartments and mediate membrane vesicle trafficking using distinct pathways. In humans, loss-of-function mutations in this gene have been linked to specific adapter complex 4 deficiency disorders including hereditary spastic paraplegia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0030124 AP-4 adaptor complex;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCR2-1", "uniprot_id": [ { "id": "AP3S1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCR2", "type": "external" } ], "mass": 21732.0, "length": 193, "protein_name": "AP-3 complex subunit sigma-1", "gene_name": "Ap3s1", "organism": "Mouse", "refseq_name": "AP-3 complex subunit sigma-1 isoform 1", "refseq_ac": [ { "id": "NP_033811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033811", "type": "external" } ], "gene_names_uniprotkb": "Ap3s1", "gene_names_refseq": "Ap3s1", "protein_names_uniprotkb": "AP-3 complex subunit sigma-1; AP-3 complex subunit sigma-3A; Adaptor-related protein complex 3 subunit sigma-1; Sigma-3A-adaptin; Sigma-adaptin 3a; Sigma3A-adaptin", "protein_names_refseq": "AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-1 isoform 1; AP-3 complex subunit sigma-1; adapter-related protein complex 3 sigma-1 subunit; adaptor-related protein complex AP-3, sigma 1 subunit; sigma-3A-adaptin; sigma-adaptin 3a", "tax_id": 10090, "disease": "", "pathway": " (mmu:11777); (R-MMU-432722)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12967569;16452087;21750661;21998198;9792713", "class_list": "", "function": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes the sigma subunit of the heterotetrameric adaptor protein complex AP-3 which is involved in the formation of specialized lysosome-related compartments such as melanosomes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on chromosomes 1, 8, 16, 17 and X. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88670", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005802 trans-Golgi network;GO:0030123 AP-3 adaptor complex", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0060155 platelet dense granule organization;GO:0016192 vesicle-mediated transport;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D742-1", "uniprot_id": [ { "id": "AP5S1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D742", "type": "external" } ], "mass": 18806.0, "length": 170, "protein_name": "AP-5 complex subunit sigma-1", "gene_name": "Ap5s1", "organism": "Mouse", "refseq_name": "AP-5 complex subunit sigma-1 isoform c", "refseq_ac": [ { "id": "NP_001277961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277961", "type": "external" } ], "gene_names_uniprotkb": "Ap5s1; 2310035K24Rik", "gene_names_refseq": "0610038L13Rik; 2310035K24Rik; Ap5s1; sigma5", "protein_names_uniprotkb": "AP-5 complex subunit sigma-1; Adaptor-related protein complex 5 sigma subunit; Sigma5", "protein_names_refseq": "AP-5 complex subunit sigma-1 isoform c; AP-5 complex subunit sigma-1; adapter-related protein complex 5 sigma subunit; adaptor-related protein complex 5 sigma subunit; protein C20orf29 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69596)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANC8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0016192 vesicle-mediated transport;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D742-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFQ3-1", "uniprot_id": [ { "id": "AQR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFQ3", "type": "external" } ], "mass": 170294.0, "length": 1481, "protein_name": "RNA helicase aquarius", "gene_name": "Aqr", "organism": "Mouse", "refseq_name": "RNA helicase aquarius isoform b", "refseq_ac": [ { "id": "NP_001277717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277717", "type": "external" } ], "gene_names_uniprotkb": "Aqr; Kiaa0560", "gene_names_refseq": "Aqr; mKIAA0560", "protein_names_uniprotkb": "RNA helicase aquarius; 3.6.4.13; Intron-binding protein of 160 kDa", "protein_names_refseq": "RNA helicase aquarius isoform b; RNA helicase aquarius; intron-binding protein aquarius; intron-binding protein of 160 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:11834); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-72163)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "15557165;21750661;22872234;25428506;25605945;30084848;30779550;31219806;34428180;39627609;9626505", "class_list": "", "function": "Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing., [UniProtKB, UniProtKB]; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97871;Q3U9N1;Q3ULE8;Q80TX8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003727 single-stranded RNA binding;GO:0034458 3'-5' RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CFQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJJ3-1", "uniprot_id": [ { "id": "AQP9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJJ3", "type": "external" } ], "mass": 31764.0, "length": 295, "protein_name": "Aquaporin-9", "gene_name": "Aqp9", "organism": "Mouse", "refseq_name": "aquaporin-9 isoform 1", "refseq_ac": [ { "id": "NP_071309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071309", "type": "external" } ], "gene_names_uniprotkb": "Aqp9", "gene_names_refseq": "1700020I22Rik; AQP-9; Aqp9", "protein_names_uniprotkb": "Aquaporin-9; AQP-9; Aquaglyceroporin-9", "protein_names_refseq": "aquaglyceroporin-9; aquaporin-9 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64008); (R-MMU-432030); (R-MMU-432047)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10777495;11972053;12351427;16698796;17360690;19805235;21750661;22081610;23042941;26837049;32748371;34428180;37602667;37647868;38064372", "class_list": "", "function": "AQP9 has a role in osteoclast differentiation, specifically in the fusion process, [RefSeq, PubMed]; AQP9 is important for hepatic glycerol metabolism and may play a role in glycerol and glucose metabolism in diabetes mellitus., [RefSeq, PubMed]; Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:22081610). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (PubMed:17360690, PubMed:22081610). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (By similarity). AQP9 may also facilitate hepatic urea extrusion (PubMed:22081610, PubMed:23042941). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:32748371). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:11972053, PubMed:19805235). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Aquaporin 9 causes recurrent spontaneous abortion by inhibiting trophoblast cell epithelial-mesenchymal transformation and invasion through the PI3K/AKT pathwaydagger., [RefSeq, PubMed]; Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice., [RefSeq, PubMed]; Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9., [RefSeq, PubMed]; Effects of Elevated Intraocular Pressure on Retinal Ganglion Cell Density and Expression and Interaction of Retinal Aquaporin 9 and Monocarboxylate Transporters., [RefSeq, PubMed]; This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015265 urea channel activity;GO:0005345 purine nucleobase transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0071320 cellular response to cAMP;GO:0015722 canalicular bile acid transport;GO:0006833 water transport;GO:0015793 glycerol transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JJJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1P8-1", "uniprot_id": [ { "id": "ANGL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1P8", "type": "external" } ], "mass": 45538.0, "length": 410, "protein_name": "Angiopoietin-related protein 4", "gene_name": "Angptl4", "organism": "Mouse", "refseq_name": "angiopoietin-related protein 4 precursor", "refseq_ac": [ { "id": "NP_065606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065606", "type": "external" } ], "gene_names_uniprotkb": "Angptl4; Farp; Fiaf; Ng27", "gene_names_refseq": "Angptl4; Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgarg; Pgar; Pp1158", "protein_names_uniprotkb": "Angiopoietin-related protein 4; 425O18-1; Angiopoietin-like protein 4; Fasting-induced adipose factor; HFARP; Hepatic fibrinogen/angiopoietin-related protein; Secreted protein Bk89", "protein_names_refseq": "425O18-1; angiopoietin-like protein 4; angiopoietin-related protein 4 precursor; angiopoietin-related protein 4; fasting-induced adipose factor; fibrinogen/angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; major histocompatibility complex region NG27; secreted protein Bk89", "tax_id": 10090, "disease": "", "pathway": " (mmu:57875); (R-MMU-8963889); (R-MMU-9762292)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10698685;10862772;10866690;12401877;14583458;14656967;15112104;15837923;17068295;17130448;17609370;21750661;21832056;26495903;27834691;29899519;34428180;38582960;38842666", "class_list": "", "function": "Identification of memory mechanism in tissue-resident stem cells via ANGPTL4 beyond immune cells upon viral antigen exposure., [RefSeq, PubMed]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:15837923, PubMed:17609370, PubMed:29899519). May also play a role in regulating glucose homeostasis and insulin sensitivity (PubMed:15837923, PubMed:29899519). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17130448, PubMed:21832056). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein., [UniProtKB, UniProtKB]; Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability., [RefSeq, PubMed]; Potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q78ZJ9;Q9JHX7;Q9JLX7", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0055102 lipase inhibitor activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0043335 protein unfolding;GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z1P8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4A0-1", "uniprot_id": [ { "id": "AQP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4A0", "type": "external" } ], "mass": 30709.0, "length": 293, "protein_name": "Aquaporin-6", "gene_name": "Aqp6", "organism": "Mouse", "refseq_name": "aquaporin-6", "refseq_ac": [ { "id": "NP_780296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780296", "type": "external" } ], "gene_names_uniprotkb": "Aqp6", "gene_names_refseq": "Aqp6", "protein_names_uniprotkb": "Aquaporin-6; AQP-6", "protein_names_refseq": "AQP-6; aquaporin-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:11831)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability. It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005253 monoatomic anion channel activity;GO:0015112 nitrate transmembrane transporter activity;GO:0015250 water channel activity;GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0042476 odontogenesis;GO:0003097 renal water transport;GO:0006833 water transport;GO:0015670 carbon dioxide transport;GO:0015706 nitrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C4A0-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHJ2-1", "uniprot_id": [ { "id": "AQP12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHJ2", "type": "external" } ], "mass": 31290.0, "length": 290, "protein_name": "Aquaporin-12", "gene_name": "Aqp12", "organism": "Mouse", "refseq_name": "aquaporin-12 isoform 1", "refseq_ac": [ { "id": "NP_808255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808255", "type": "external" } ], "gene_names_uniprotkb": "Aqp12", "gene_names_refseq": "Aqp12; mAQP12", "protein_names_uniprotkb": "Aquaporin-12; AQP-12", "protein_names_refseq": "AQP-12; aquaporin-12 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208760); (R-MMU-432047)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15809071;19726746;31219806", "class_list": "", "function": "A role of AQP12 in digestive enzyme secretion such as maturation and exocytosis of secretory granules, [RefSeq, PubMed]; AQP12 may function in the mechanisms that control the proper secretion of pancreatic fluid following rapid and intense stimulation., [RefSeq, PubMed]; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNM4", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CHJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1C9-1", "uniprot_id": [ { "id": "APBB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1C9", "type": "external" } ], "mass": 52638.0, "length": 486, "protein_name": "Amyloid-beta A4 precursor protein-binding family B member 3", "gene_name": "Apbb3", "organism": "Mouse", "refseq_name": "amyloid-beta A4 precursor protein-binding family B member 3 isoform 1", "refseq_ac": [ { "id": "NP_666197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666197", "type": "external" } ], "gene_names_uniprotkb": "Apbb3; Fe65l2", "gene_names_refseq": "Apbb3; Fe65l2; Rirl2; TR2S", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family B member 3; Fe65L2; Protein Fe65-like 2", "protein_names_refseq": "amyloid beta (A4) precursor protein-binding, family B, member 3; amyloid-beta A4 precursor protein-binding family B member 3 isoform 1; protein Fe65-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:225372)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May modulate the internalization of amyloid-beta precursor protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription;GO:0050714 positive regulation of protein secretion;GO:1901988 negative regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2N1-1", "uniprot_id": [ { "id": "AQP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2N1", "type": "external" } ], "mass": 31568.0, "length": 292, "protein_name": "Aquaporin-3", "gene_name": "Aqp3", "organism": "Mouse", "refseq_name": "aquaporin-3", "refseq_ac": [ { "id": "NP_057898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057898", "type": "external" } ], "gene_names_uniprotkb": "Aqp3", "gene_names_refseq": "AQP-2; Aqp3", "protein_names_uniprotkb": "Aquaporin-3; AQP-3; Aquaglyceroporin-3", "protein_names_refseq": "AQP-3; aquaglyceroporin-3; aquaporin-3", "tax_id": 10090, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); hypothyroidism (Disease Ontology:DOID:1459); brain ischemia (Disease Ontology:DOID:2316); brain edema (Disease Ontology:DOID:4724)", "pathway": " (mmu:11828); (R-MMU-432040); (R-MMU-432047)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10737773;10777495;11880378;12771381;16641094;17429015;27802388;28011936", "class_list": "glycogene", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11880378, PubMed:12771381, PubMed:17429015, PubMed:19468303). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (PubMed:11880378, PubMed:12771381). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (PubMed:10737773)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU75;Q9JJN8;Q9WTJ3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015166 polyol transmembrane transporter activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0071456 cellular response to hypoxia;GO:0032526 response to retinoic acid;GO:0042476 odontogenesis;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R2N1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JG3-1", "uniprot_id": [ { "id": "ANX13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JG3", "type": "external" } ], "mass": 35922.0, "length": 317, "protein_name": "Annexin A13", "gene_name": "Anxa13", "organism": "Mouse", "refseq_name": "annexin A13", "refseq_ac": [ { "id": "NP_081487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081487", "type": "external" } ], "gene_names_uniprotkb": "Anxa13", "gene_names_refseq": "1810034H17Rik; Anxa13", "protein_names_uniprotkb": "Annexin A13; Annexin XIII; Annexin-13", "protein_names_refseq": "annexin A13; annexin XIII; annexin-13", "tax_id": 10090, "disease": "", "pathway": " (mmu:69787)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11961095;30059200;30610115", "class_list": "", "function": "A mechanism for how the association of the ANX A13a isoform with the membrane is regulated, [RefSeq, PubMed]; Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup., [UniProtKB, UniProtKB]; Mouse annexin A13 cDNA was used to map the gene to an orthologous linkage group in mouse chromosome 15 (between Sdc2 and Myc by backcross analysis)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding;GO:1901611 phosphatidylglycerol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ52-1", "uniprot_id": [ { "id": "ANTR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ52", "type": "external" } ], "mass": 62308.0, "length": 562, "protein_name": "Anthrax toxin receptor 1", "gene_name": "Antxr1", "organism": "Mouse", "refseq_name": "anthrax toxin receptor 1 precursor", "refseq_ac": [ { "id": "NP_473382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473382", "type": "external" } ], "gene_names_uniprotkb": "Antxr1; Atr; Tem8", "gene_names_refseq": "2310008J16Rik; 2810405N18Rik; Antrx1; Antxr1; Tem8", "protein_names_uniprotkb": "Anthrax toxin receptor 1; Tumor endothelial marker 8", "protein_names_refseq": "anthrax toxin receptor 1 precursor; tumor endothelial marker 8", "tax_id": 10090, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); colorectal carcinoma (Disease Ontology:DOID:0080199); GAPO syndrome (Disease Ontology:DOID:0112249); breast cancer (Disease Ontology:DOID:1612); gallbladder carcinoma (Disease Ontology:DOID:4948); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:69538)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11559528;15689409;17459655;19617532;19622764;21183079;21750661;32244499;34165155;34428180", "class_list": "", "function": "Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 plays only a minor role., [RefSeq, PubMed]; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis (PubMed:19622764). Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Targeted silencing of TEM8 suppresses nonsmall cell lung cancer tumor growth via the ERK/Bcl2 signaling pathway., [RefSeq, PubMed]; The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells., [RefSeq, PubMed]; This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q505H2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0005518 collagen binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0031258 lamellipodium membrane;GO:0031527 filopodium membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0001568 blood vessel development;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0034446 substrate adhesion-dependent cell spreading;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CZ52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D416-1", "uniprot_id": [ { "id": "AR13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D416", "type": "external" } ], "mass": 43463.0, "length": 372, "protein_name": "ADP-ribosylation factor-like protein 13A", "gene_name": "Arl13a", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 13A", "refseq_ac": [ { "id": "NP_083223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083223", "type": "external" } ], "gene_names_uniprotkb": "Arl13a; Arl13", "gene_names_refseq": "4933422M21Rik; Arl13a; Arl13", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 13A", "protein_names_refseq": "ADP-ribosylation factor-like 13; ADP-ribosylation factor-like protein 13A", "tax_id": 10090, "disease": "", "pathway": " (mmu:74448)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497J4", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:1905515 non-motile cilium assembly;GO:0097500 receptor localization to non-motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D416-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7N9-1", "uniprot_id": [ { "id": "APMAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7N9", "type": "external" } ], "mass": 46434.0, "length": 415, "protein_name": "Adipocyte plasma membrane-associated protein", "gene_name": "Apmap", "organism": "Mouse", "refseq_name": "adipocyte plasma membrane-associated protein isoform 1", "refseq_ac": [ { "id": "NP_082253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082253", "type": "external" } ], "gene_names_uniprotkb": "Apmap", "gene_names_refseq": "2310001A20Rik; Apmap", "protein_names_uniprotkb": "Adipocyte plasma membrane-associated protein; Protein DD16", "protein_names_refseq": "adipocyte plasma membrane-associated protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71881)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11583587;20552250;28559441;30059200;30899004;31219806;34428180;40997131", "class_list": "", "function": "Data demonstrate that APMAP contains a functional PPARgamma binding site, and that APMAP translocates from the endoplasmatic reticulum to the plasma membrane during adipocyte differentiation, [RefSeq, PubMed]; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate (By similarity). May play a role in adipocyte differentiation., [UniProtKB]; These data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AQX3;Q3U4F4", "ec_number_list": [], "go_molecular_function": "GO:0004064 arylesterase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D7N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHZ2-1", "uniprot_id": [ { "id": "ANKH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHZ2", "type": "external" } ], "mass": 54298.0, "length": 492, "protein_name": "Mineralization regulator ANKH", "gene_name": "Ankh", "organism": "Mouse", "refseq_name": "mineralization regulator ANKH", "refseq_ac": [ { "id": "NP_065065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065065", "type": "external" } ], "gene_names_uniprotkb": "Ankh; Ank", "gene_names_refseq": "Ankh; Ank; D15Ertd221e; mKIAA1581", "protein_names_uniprotkb": "Mineralization regulator ANKH; ANK; ATP carrier protein ANKH; Fn54 protein; Progressive ankylosis protein homolog", "protein_names_refseq": "ATP carrier protein ANKH; fn54 protein; mineralization regulator ANKH; progressive ankylosis protein homolog; progressive ankylosis protein", "tax_id": 10090, "disease": "craniometaphyseal dysplasia (Disease Ontology:DOID:0080033); autosomal dominant craniometaphyseal dysplasia (Disease Ontology:DOID:0080801); chondrocalcinosis (Disease Ontology:DOID:1156)", "pathway": " (mmu:11732); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10894769;20943778;30084848;32639996;34428180;35147247;37468461", "class_list": "", "function": "Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc. Publication Status: Online-Only, [RefSeq, PubMed]; The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate., [RefSeq, PubMed]; The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP. Publication Status: Online-Only, [RefSeq, PubMed]; Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35138;O35139", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030500 regulation of bone mineralization;GO:0035435 phosphate ion transmembrane transport;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0R4-1", "uniprot_id": [ { "id": "APEL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0R4", "type": "external" } ], "mass": 8658.0, "length": 77, "protein_name": "Apelin", "gene_name": "Apln", "organism": "Mouse", "refseq_name": "apelin preproprotein", "refseq_ac": [ { "id": "NP_038940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038940", "type": "external" } ], "gene_names_uniprotkb": "Apln; Apel", "gene_names_refseq": "6030430G11Rik; Apel; Apln", "protein_names_uniprotkb": "Apelin; APJ endogenous ligand", "protein_names_refseq": "APJ endogenous ligand; apelin preproprotein; preproapelin", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); atrial fibrillation (Disease Ontology:DOID:0060224); hypertension (Disease Ontology:DOID:10763); morbid obesity (Disease Ontology:DOID:11981); coronary stenosis (Disease Ontology:DOID:4248); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:30878); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10525157;11359874;11744380;15677759;22810587;26611206;28854362;28890073;38525542;38924877", "class_list": "", "function": "Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model., [RefSeq, PubMed]; Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels., [RefSeq, PubMed]; Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice., [RefSeq, PubMed]; Insulin and obesity up-regulate apelin in adipocytes., [RefSeq, PubMed]; Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ) (PubMed:22810587). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR (PubMed:22810587). Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (PubMed:22810587). On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor (PubMed:22810587). Apelin also blunts mechanical stretch-induced hypertrophic induction from APLNR (PubMed:22810587). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (PubMed:10525157). Plays a role in early coronary blood vessels formation (PubMed:28890073). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (PubMed:11359874)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play important roles in a broad range of physiological processes such as cardiac contractility, blood pressure, blood vessel growth, appetite and drink behavior, and pituitary hormone secretion. Mice lacking the encoded protein develop progressive heart failure and exhibit a shorter bleeding time, prothrombotic profile and increased bone mass. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0031704 apelin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1T1-1", "uniprot_id": [ { "id": "AP3B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1T1", "type": "external" } ], "mass": 122740.0, "length": 1105, "protein_name": "AP-3 complex subunit beta-1", "gene_name": "Ap3b1", "organism": "Mouse", "refseq_name": "AP-3 complex subunit beta-1", "refseq_ac": [ { "id": "NP_033810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033810", "type": "external" } ], "gene_names_uniprotkb": "Ap3b1", "gene_names_refseq": "AP-3; Ap3b1; Hps2; beta3A; pearl; pe; rim2", "protein_names_uniprotkb": "AP-3 complex subunit beta-1; Adaptor protein complex AP-3 subunit beta-1; Adaptor-related protein complex 3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain", "protein_names_refseq": "AP-3 complex subunit beta-1; adapter-related protein complex 3 subunit beta-1; adaptor protein complex AP-3 beta-1 subunit; adaptor protein complex AP-3 subunit beta-1; adaptor-related protein complex 3 subunit beta-1; adaptor-related protein complex AP-3 beta 1 subunit; beta-3A-adaptin; beta3A-adaptin; clathrin assembly protein complex 3 beta-1 large chain; recombination induced mutation 2", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 2 (Disease Ontology:DOID:0060540); neutropenia (Disease Ontology:DOID:1227); platelet storage pool deficiency (Disease Ontology:DOID:2223); interstitial lung disease (Disease Ontology:DOID:3082); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:11774); (R-MMU-432722)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11056055;17242355;17873058;19144319;20173027;21183079;21750661;21998198;22872234;25428506;30084848;30779550;31219806;31599954;33300544;34203471;34428180;35820727;37723322;37828378;39627609;9931340", "class_list": "", "function": "Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1., [RefSeq, PubMed]; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ08;Q91YR4", "ec_number_list": [], "go_molecular_function": "GO:0030742 GTP-dependent protein binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0030665 clathrin-coated vesicle membrane;GO:0005802 trans-Golgi network;GO:0030123 AP-3 adaptor complex", "go_biological_process": "GO:1903232 melanosome assembly;GO:0030851 granulocyte differentiation;GO:0098773 skin epidermis development;GO:0090152 establishment of protein localization to mitochondrial membrane involved in mitochondrial fission;GO:0003016 respiratory system process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9Z1T1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YN9-1", "uniprot_id": [ { "id": "BAG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YN9", "type": "external" } ], "mass": 23474.0, "length": 210, "protein_name": "BAG family molecular chaperone regulator 2", "gene_name": "Bag2", "organism": "Mouse", "refseq_name": "BAG family molecular chaperone regulator 2", "refseq_ac": [ { "id": "NP_663367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663367", "type": "external" } ], "gene_names_uniprotkb": "Bag2", "gene_names_refseq": "2610042A13Rik; Bag2", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 2; BAG-2; Bcl-2-associated athanogene 2", "protein_names_refseq": "BAG family molecular chaperone regulator 2; BAG-2; bcl-2-associated athanogene 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:213539); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19029896;21750661;22684061;25428506;26538564;28135057;30084848;31711362", "class_list": "", "function": "BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy., [RefSeq, PubMed]; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release., [UniProtKB, UniProtKB]; Findings support the notion that BAG2 is an upstream regulator of the PINK1/PARKIN signaling pathway., [RefSeq, PubMed]; Free and Hsc70-bound crystal structures of Bag2-BNB show its dimeric structure, in which a flanking linker helix and loop bind to Hsc70 to promote nucleotide exchange., [RefSeq, PubMed]; Native Bag2-NTD crystals diffracted to 2.27 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 75.5, b = 84.7, c = 114.1 A, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMR7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0010954 positive regulation of protein processing;GO:0050821 protein stabilization;GO:0031397 negative regulation of protein ubiquitination;GO:1901800 positive regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91YN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0J2-1", "uniprot_id": [ { "id": "B3GN7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0J2", "type": "external" } ], "mass": 45379.0, "length": 397, "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "gene_name": "B3gnt7", "organism": "Mouse", "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "refseq_ac": [ { "id": "NP_660257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660257", "type": "external" } ], "gene_names_uniprotkb": "B3gnt7", "gene_names_refseq": "B3gnt7; C330001H22Rik; beta-3GnT7", "protein_names_uniprotkb": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; 2.4.1.-; BGnT-7; Beta-1,3-Gn-T7; Beta-1,3-N-acetylglucosaminyltransferase 7; Beta3Gn-T7", "protein_names_refseq": "BGnT-7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; beta-1,3-Gn-T7; beta-1,3-N-acetylglucosaminyltransferase 7; beta3Gn-T7", "tax_id": 10090, "disease": "", "pathway": " (mmu:227327); (R-MMU-2022854); (R-MMU-913709)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12061784;21750661;29625490;38886669", "class_list": "glycogene;glycosyltransferase", "function": "B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Beta3GnT7 may play a role in preventing cells from migrating out of the original tissues, [RefSeq, PubMed]; N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N-and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (By similarity). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:29625490). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (PubMed:12061784)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3L9;Q3V283;Q6PA02;Q8BJS5;Q8K437", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.149", "type": "external" }, { "id": "2.4.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.147", "type": "external" }, { "id": "2.4.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.146", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0J2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBX9-1", "uniprot_id": [ { "id": "BIVM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBX9", "type": "external" } ], "mass": 56622.0, "length": 502, "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "Bivm", "organism": "Mouse", "refseq_name": "basic immunoglobulin-like variable motif-containing protein", "refseq_ac": [ { "id": "NP_653141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653141", "type": "external" } ], "gene_names_uniprotkb": "Bivm", "gene_names_refseq": "Bivm", "protein_names_uniprotkb": "Basic immunoglobulin-like variable motif-containing protein", "protein_names_refseq": "basic immunoglobulin-like variable motif-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:246229)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCP3", "ec_number_list": [], "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CBX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DM65-1", "uniprot_id": [ { "id": "BECN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DM65", "type": "external" } ], "mass": 50287.0, "length": 447, "protein_name": "Beclin-2", "gene_name": "Becn2", "organism": "Mouse", "refseq_name": "beclin-2", "refseq_ac": [ { "id": "NP_001277621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277621", "type": "external" } ], "gene_names_uniprotkb": "Becn2", "gene_names_refseq": "Beclin-2; Becn2; Gm104; Gm38100", "protein_names_uniprotkb": "Beclin-2", "protein_names_refseq": "beclin-2", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:226720)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;23954414;26929373;27305347;32865519;36719945;38284902", "class_list": "", "function": "A protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids, [RefSeq, PubMed]; Beclin 2 negatively regulates innate immune signaling and tumor development., [RefSeq, PubMed]; Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy., [RefSeq, PubMed]; Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G protein-coupled receptors turnover. Regulates degradation in lysosomes of a variety of G protein-coupled receptors via its interaction with GPRASP1/GASP1., [UniProtKB, PubMed]; Monoallelic loss of Becn2 accelerates progression of vGPCR-induced lesions resembling human Kaposi's sarcoma. Beclin 2 is protects against the pathogenic effects of KSHV GPCR by facilitating its endolysosomal degradation., [RefSeq, PubMed]; Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation., [RefSeq, PubMed]; Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "S5WDD2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0000407 phagophore assembly site;GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0042593 glucose homeostasis;GO:0006914 autophagy;GO:0008333 endosome to lysosome transport;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0DM65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7L9Z8-1", "uniprot_id": [ { "id": "AT2C2_MOUSE", "url": "https://www.uniprot.org/uniprot/A7L9Z8", "type": "external" } ], "mass": 102528.0, "length": 944, "protein_name": "Calcium-transporting ATPase type 2C member 2", "gene_name": "Atp2c2", "organism": "Mouse", "refseq_name": "calcium-transporting ATPase type 2C member 2", "refseq_ac": [ { "id": "NP_081198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081198", "type": "external" } ], "gene_names_uniprotkb": "Atp2c2; Kiaa0703; Spca2", "gene_names_refseq": "1810010G06Rik; Atp2c2; Spca2; mKIAA0703", "protein_names_uniprotkb": "Calcium-transporting ATPase type 2C member 2; 7.2.2.10; ATPase 2C2; Ca(2+)/Mn(2+)-ATPase 2C2; SPCA2; Secretory pathway Ca(2+)-transporting ATPase type 2", "protein_names_refseq": "ATPase 2C2; Ca(2+)/Mn(2+)-ATPase 2C2; Secretory pathway Ca(2+)-ATPase 2; calcium-transporting ATPase type 2C member 2; secretory pathway Ca(2+)-transporting ATPase type 2; secretory pathway Ca2+-ATPase", "tax_id": 10090, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429)", "pathway": " (mmu:69047); (R-MMU-936837)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15677451;20599950;21750661;23840669;27017909;31219806;34203471", "class_list": "", "function": "ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (By similarity) (PubMed:23840669)., [UniProtKB, UniProtKB, PubMed]; Atp2c2 transcription is regulated by MIST1, [RefSeq, PubMed]; SPCA2 and Orai1 function together to regulate store-independent calcium entry. Publication Status: Online-Only, [RefSeq, PubMed]; The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca(2+) ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU19", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0140613 P-type manganese transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0090280 positive regulation of calcium ion import;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A7L9Z8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UI43-1", "uniprot_id": [ { "id": "BABA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UI43", "type": "external" } ], "mass": 36793.0, "length": 333, "protein_name": "BRISC and BRCA1-A complex member 1", "gene_name": "Babam1", "organism": "Mouse", "refseq_name": "BRISC and BRCA1-A complex member 1", "refseq_ac": [ { "id": "NP_080912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080912", "type": "external" } ], "gene_names_uniprotkb": "Babam1; Merit40; Nba1", "gene_names_refseq": "5430437P03Rik; Babam1; Merit40", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex", "protein_names_refseq": "BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1-A complex", "tax_id": 10090, "disease": "", "pathway": " (mmu:68251); (R-MMU-5689901); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25636339;26338419;28135057;31219806;34428180", "class_list": "", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination., [UniProtKB, UniProtKB]; MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation., [RefSeq, PubMed]; Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5Q8;Q99JU2;Q9CTJ4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UI43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23780-1", "uniprot_id": [ { "id": "BGAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P23780", "type": "external" } ], "mass": 73121.0, "length": 647, "protein_name": "Beta-galactosidase", "gene_name": "Glb1", "organism": "Mouse", "refseq_name": "beta-galactosidase preproprotein", "refseq_ac": [ { "id": "NP_033882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033882", "type": "external" } ], "gene_names_uniprotkb": "Glb1; Bgl; Glb-1", "gene_names_refseq": "Bge; Bgl-e; Bgl-s; Bgl-t; Bgl; Bgs; Bgt; C130097A14Rik; Glb1", "protein_names_uniprotkb": "Beta-galactosidase; 3.2.1.23; Acid beta-galactosidase; Lactase", "protein_names_refseq": "acid beta-galactosidase; beta-galactosidase preproprotein; lactase", "tax_id": 10090, "disease": "GM1 gangliosidosis type 3 (Disease Ontology:DOID:0080489); GM1 gangliosidosis type 2 (Disease Ontology:DOID:0080501); GM1 gangliosidosis type 1 (Disease Ontology:DOID:0080502); mucopolysaccharidosis type IVB (Disease Ontology:DOID:0111392); mucopolysaccharidosis IV (Disease Ontology:DOID:12804); GM1 gangliosidosis (Disease Ontology:DOID:3322)", "pathway": " (mmu:12091); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-4085001); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "11465105;18250455;1906271;2124109;21750661;25428506;26495903;28011936;29187734;30084848;30779550;31219806;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0016936 galactoside binding;GO:0004565 beta-galactosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0005975 carbohydrate metabolic process;GO:0019388 galactose catabolic process;GO:0042340 keratan sulfate proteoglycan catabolic process;GO:0051413 response to cortisone", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P23780-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20722-1", "uniprot_id": [ { "id": "BMP6_MOUSE", "url": "https://www.uniprot.org/uniprot/P20722", "type": "external" } ], "mass": 56432.0, "length": 510, "protein_name": "Bone morphogenetic protein 6", "gene_name": "Bmp6", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 6 preproprotein", "refseq_ac": [ { "id": "NP_031582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031582", "type": "external" } ], "gene_names_uniprotkb": "Bmp6; Bmp-6; Vgr1", "gene_names_refseq": "Bmp6; D13Wsu115e; Vgr1", "protein_names_uniprotkb": "Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VGR-1", "protein_names_refseq": "VG-1-related protein; bone morphogenetic protein 6 preproprotein", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); prostate cancer (Disease Ontology:DOID:10283); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12161)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14623234;19252486;19892989;21750661;2734307;30097509;31800957;32464486;37313693;8089189;9069123;9664685", "class_list": "", "function": "BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial infarction model by upregulating AP-1/CEMIP expression., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:19252486). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RRV6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031982 vesicle;GO:0032991 protein-containing complex;GO:0150005 enzyme activator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P20722-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PB60-1", "uniprot_id": [ { "id": "GASP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PB60", "type": "external" } ], "mass": 59823.0, "length": 539, "protein_name": "G protein-coupled receptor associated sorting protein 3", "gene_name": "Bhlhb9; Gprasp3", "organism": "Mouse", "refseq_name": "G protein-coupled receptor associated sorting protein 3", "refseq_ac": [ { "id": "NP_001091692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091692", "type": "external" } ], "gene_names_uniprotkb": "Bhlhb9; Gprasp3; Bhlhb9; Kiaa1701", "gene_names_refseq": "2700087I09Rik; Bhlhb9; Gprasp3", "protein_names_uniprotkb": "G protein-coupled receptor associated sorting protein 3; Protein BHLHb9; bHLHb9", "protein_names_refseq": "G protein-coupled receptor associated sorting protein 3; protein BHLHB9", "tax_id": 10090, "disease": "", "pathway": " (mmu:70237)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21199326;21750661;22172954;23391701;31219806", "class_list": "", "function": "In vivo neural over-expression of transgenic p60TRP with its neuroprotective therapeutic potential significantly affects cardiovascular capacities., [RefSeq, PubMed]; Our data suggests that in vivo overexpression of neuronal p60TRP significantly affects cognitive and neuroprotective capacities., [RefSeq, PubMed]; Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0C1;Q69ZD0", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007611 learning or memory;GO:0043524 negative regulation of neuron apoptotic process;GO:0051965 positive regulation of synapse assembly;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PB60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9K3-1", "uniprot_id": [ { "id": "AVEN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9K3", "type": "external" } ], "mass": 37195.0, "length": 342, "protein_name": "Cell death regulator Aven", "gene_name": "Aven", "organism": "Mouse", "refseq_name": "cell death regulator Aven isoform 1", "refseq_ac": [ { "id": "NP_083120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083120", "type": "external" } ], "gene_names_uniprotkb": "Aven", "gene_names_refseq": "1700013A01Rik; 1700056A21Rik; Aven; mAven-L; mAven-S", "protein_names_uniprotkb": "Cell death regulator Aven", "protein_names_refseq": "cell death regulator Aven isoform 1; cell death regulator Aven", "tax_id": 10090, "disease": "", "pathway": " (mmu:74268); (R-MMU-111458); (R-MMU-9627069)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12971998;15345747;18996183;21183079;21750661;37816050", "class_list": "", "function": "Activated in irradiated tissues protected from radiodamage by treatment with recombinant superoxide dismutase (MnSOD), [RefSeq, PubMed]; Downregulation of apoptotic repressor AVEN exacerbates cardiac injury after myocardial infarction., [RefSeq, PubMed]; One of the cDNA clones obtained by selective PCR subtraction cloning matched two cDNA sequences in the mouse testis cDNA database, and was highly homologous to Aven, a human gene regulating cell death., [RefSeq, PubMed]; Protects against apoptosis mediated by Apaf-1., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AGL4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D9K3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97504-1", "uniprot_id": [ { "id": "BMX_MOUSE", "url": "https://www.uniprot.org/uniprot/P97504", "type": "external" } ], "mass": 75001.0, "length": 651, "protein_name": "Cytoplasmic tyrosine-protein kinase BMX", "gene_name": "Bmx", "organism": "Mouse", "refseq_name": "cytoplasmic tyrosine-protein kinase BMX", "refseq_ac": [ { "id": "NP_033889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033889", "type": "external" } ], "gene_names_uniprotkb": "Bmx", "gene_names_refseq": "Bmx; Etk/Bmx; Etk; Tyro8", "protein_names_uniprotkb": "Cytoplasmic tyrosine-protein kinase BMX; 2.7.10.2; Bone marrow tyrosine kinase gene in chromosome X protein homolog", "protein_names_refseq": "TYRO8 protein tyrosine kinase 8; bone marrow tyrosine kinase gene in chromosome X protein homolog; cytoplasmic tyrosine-protein kinase BMX", "tax_id": 10090, "disease": "", "pathway": " (mmu:12169); (R-MMU-111465); (R-MMU-1660499)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11114746;11340625;11416142;17624943;21750661;30084848;31910739;34536556;9323053", "class_list": "", "function": "Data show that bone marrow kinase on the X chromosome (BMX) specifically repressed thrombin-PAR1 (protease-activated receptor-1) signaling in endothelial cells by directly phosphorylating PAR1 and promoting its internalization and deactivation. Erratum:[Circ Res. 2025 Jul 18;137(3):e63. doi: 10.1161/RES.0000000000000723. PMID: 40674453], [RefSeq, PubMed]; Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx., [RefSeq, PubMed]; Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G protein-coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P97504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12265-1", "uniprot_id": [ { "id": "BGLR_MOUSE", "url": "https://www.uniprot.org/uniprot/P12265", "type": "external" } ], "mass": 74195.0, "length": 648, "protein_name": "Beta-glucuronidase", "gene_name": "Gusb", "organism": "Mouse", "refseq_name": "beta-glucuronidase isoform 1 precursor", "refseq_ac": [ { "id": "NP_034498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034498", "type": "external" } ], "gene_names_uniprotkb": "Gusb; Gus-s; Gus", "gene_names_refseq": "Gur; Gus-r; Gus-s; Gus-t; Gus-u; Gusb; Gus; Gut; asd; g", "protein_names_uniprotkb": "Beta-glucuronidase; 3.2.1.31", "protein_names_refseq": "adipose storage deficiency; beta-glucuronidase isoform 1 precursor; beta-glucuronidase", "tax_id": 10090, "disease": "mucopolysaccharidosis (Disease Ontology:DOID:12798); mucopolysaccharidosis type VII (Disease Ontology:DOID:12803); peritonitis (Disease Ontology:DOID:8283)", "pathway": " (mmu:110006); (R-MMU-2024101); (R-MMU-2160916); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2394691;2779578;2835664;2891607;31219806;3196706;3397060;34203471;34428180;37178109;37828378", "class_list": "glycogene;glycosylhydrolase", "function": "Gut dysbiosis-derived beta-glucuronidase promotes the development of endometriosis., [RefSeq, PubMed]; Plays an important role in the degradation of dermatan and keratan sulfates., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61601;Q64473;Q64474;Q6IR10", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding;GO:0030246 carbohydrate binding;GO:0004566 beta-glucuronidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1904888 cranial skeletal system development;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003415 chondrocyte hypertrophy;GO:0001523 retinoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P12265-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPT0-1", "uniprot_id": [ { "id": "B2L14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPT0", "type": "external" } ], "mass": 36992.0, "length": 328, "protein_name": "Apoptosis facilitator Bcl-2-like protein 14", "gene_name": "Bcl2l14", "organism": "Mouse", "refseq_name": "apoptosis facilitator Bcl-2-like protein 14", "refseq_ac": [ { "id": "NP_080054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080054", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l14", "gene_names_refseq": "4930452K23Rik; 4933405K19Rik; 9030625M01Rik; Bcl-G; Bcl2l14; Bclg", "protein_names_uniprotkb": "Apoptosis facilitator Bcl-2-like protein 14; Bcl2-L-14", "protein_names_refseq": "BCL2-like 14 (apoptosis facilitator); apoptosis facilitator Bcl-2-like protein 14; apoptosis regulator BCL-G", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286)", "pathway": " (mmu:66813)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22914326;23059823;25180634", "class_list": "", "function": "Bcl-G is expressed highly in mature spermatids in the testis, CD8(+) conventional dendritic cells (DCs) in hematopoietic tissues and diverse epithelial cell types, including those lining the gastrointestinal and respiratory tracts. Publication Status: Online-Only, [RefSeq, PubMed]; CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival., [RefSeq, PubMed]; Plays a role in apoptosis., [UniProtKB]; The Bcl-G interacts specifically with proteins of the transport particle protein complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVA7;Q8R141;Q9D3W3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CPT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHE3-1", "uniprot_id": [ { "id": "ATCAY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHE3", "type": "external" } ], "mass": 42178.0, "length": 372, "protein_name": "Caytaxin", "gene_name": "Atcay", "organism": "Mouse", "refseq_name": "caytaxin", "refseq_ac": [ { "id": "NP_848777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848777", "type": "external" } ], "gene_names_uniprotkb": "Atcay", "gene_names_refseq": "3322401A10Rik; Atcay; BNIP-H; CLAC; hes; ji", "protein_names_uniprotkb": "Caytaxin", "protein_names_refseq": "ataxia, cerebellar, Cayman type homolog; caytaxin; hesitant; jittery", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); Cayman type cerebellar ataxia (Disease Ontology:DOID:0060694); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:16467)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14556008;16899818;17157273;19436707;19861499;21183079;21369758;21750661;23226316;25428506;30084848;30120735", "class_list": "", "function": "Activation of DAPK1 impairs learning and memory by degrading Caytaxin during aging., [RefSeq, PubMed]; Caytaxin's role in maintaining normal neuronal function, [RefSeq, PubMed]; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites., [UniProtKB, PubMed]; Mutations of mouse Atcay are an orthologous gene model for human Cayman ataxia. Erratum:[Nat Genet. 2005 May;37(5):555], [RefSeq, PubMed]; The classical hesitant allele of Atcay is partially suppressed by CAST/Ei alleles of the nuclear export factor Nxf1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR94", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0006915 apoptotic process;GO:0032880 regulation of protein localization;GO:0048311 mitochondrion distribution;GO:2000212 negative regulation of glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BHE3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7H4-1", "uniprot_id": [ { "id": "AVPI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7H4", "type": "external" } ], "mass": 15802.0, "length": 142, "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "Avpi1", "organism": "Mouse", "refseq_name": "arginine vasopressin-induced protein 1", "refseq_ac": [ { "id": "NP_081382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081382", "type": "external" } ], "gene_names_uniprotkb": "Avpi1", "gene_names_refseq": "2310008N12Rik; Avpi1; VIT32; esu; mVIT32", "protein_names_uniprotkb": "Arginine vasopressin-induced protein 1; AVP-induced protein 1; Arginine vasopressin-induced transcript 32 protein; VIP32; VIT32", "protein_names_refseq": "AVP-induced protein 1; Esau protein; VIP32; arginine vasopressin-induced protein 1; arginine vasopressin-induced transcript 32 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69534)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12356727;15140762;21750661", "class_list": "", "function": "DDAVP stimulates transcription of VIT32 via a CRE within the proximal promoter region of the VIT32 gene., [RefSeq, PubMed]; May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7H4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJS6-1", "uniprot_id": [ { "id": "BCDO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJS6", "type": "external" } ], "mass": 63864.0, "length": 566, "protein_name": "Beta,beta-carotene 15,15'-dioxygenase", "gene_name": "Bco1", "organism": "Mouse", "refseq_name": "beta,beta-carotene 15,15'-dioxygenase isoform 1", "refseq_ac": [ { "id": "NP_067461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067461", "type": "external" } ], "gene_names_uniprotkb": "Bco1; Bcdo1; Bcdo; Bcmo1", "gene_names_refseq": "Bcdo1; Bcdo; Bcmo1; Bco1; CMO1; Cmoi; beta-CD; betaCMOOX", "protein_names_uniprotkb": "Beta,beta-carotene 15,15'-dioxygenase; 1.13.11.63; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1", "protein_names_refseq": "beta,beta-carotene 15,15'-dioxygenase isoform 1; beta,beta-carotene 15,15'-dioxygenase; beta,beta-carotene 15,15'-monooxygenase; beta-carotene 15, 15'-dioxygenase 1; beta-carotene 15,15' dioxygenase; beta-carotene cleavage enzyme; beta-carotene dioxygenase 1; carotenoid-15,15'-oxygenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:63857); (R-MMU-975634)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11092891;11237856;11401432;12759335;15951442;21750661;36150025", "class_list": "", "function": "Genetic tuning of beta-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice., [RefSeq, PubMed]; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism., [UniProtKB, PubMed, PubMed]; Transcriptional activation of the beta-carotene 15, 15'-monooxygenase gene by peroxisome proliferator-activated receptor (beta-carotene 15, 15'-monooxygenase)., [RefSeq, PubMed]; Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6K1L5;Q8C6N5;Q9ERN9", "ec_number_list": [ { "id": "1.13.11.63", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.63", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0042574 retinal metabolic process;GO:1901810 beta-carotene metabolic process;GO:0016121 carotene catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJS6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62210-1", "uniprot_id": [ { "id": "BIRC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62210", "type": "external" } ], "mass": 69676.0, "length": 612, "protein_name": "Baculoviral IAP repeat-containing protein 2", "gene_name": "Birc2", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 2", "refseq_ac": [ { "id": "NP_001278432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278432", "type": "external" } ], "gene_names_uniprotkb": "Birc2", "gene_names_refseq": "Api1; Api2; Birc2; Birc3; C-IAP1; C330006D17Rik; HIAP1; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF48; cIAP1; cIAP2; mcIAP1", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 2; 2.3.2.27; C-IAP1; Cellular inhibitor of apoptosis 1; Inhibitor of apoptosis protein 2; RING-type E3 ubiquitin transferase BIRC2; mIAP2", "protein_names_refseq": "RING-type E3 ubiquitin transferase BIRC2; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; baculoviral IAP repeat-containing protein 2; cellular inhibitor of apoptosis 1; inhibitor of apoptosis protein 2", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); breast cancer (Disease Ontology:DOID:1612); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11797); (R-MMU-111465); (R-MMU-168638); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5668541); (R-MMU-5675482); (R-MMU-5676594); (R-MMU-5689880); (R-MMU-937041); (R-MMU-9958825)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "18621737;21183079;21750661;24129315;25428506;30084848;30779550;34428180;8548810;9441758", "class_list": "", "function": "Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6S7;O08864", "ec_number_list": [ { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62210-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI16-1", "uniprot_id": [ { "id": "B3GN9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI16", "type": "external" } ], "mass": 44231.0, "length": 399, "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "gene_name": "B3gnt9", "organism": "Mouse", "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9", "refseq_ac": [ { "id": "NP_001258844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258844", "type": "external" } ], "gene_names_uniprotkb": "B3gnt9; B3gnt9-ps", "gene_names_refseq": "3-Gn-T9; B3gnt9-ps; B3gnt9; BGnT-9; beta-1; beta3Gn-T9", "protein_names_uniprotkb": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9; 2.4.1.-; BGnT-9; Beta-1,3-Gn-T9; Beta-1,3-N-acetylglucosaminyltransferase 9; Beta3Gn-T9", "protein_names_refseq": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9, pseudogene; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9; beta-1,3-Gn-T9; beta-1,3-N-acetylglucosaminyltransferase 9; beta-1,3-galactosyltransferase-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:97440); (R-MMU-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK98", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.149", "type": "external" }, { "id": "2.4.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.147", "type": "external" }, { "id": "2.4.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.146", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VI16-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZV9-1", "uniprot_id": [ { "id": "DHRS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZV9", "type": "external" } ], "mass": 26753.0, "length": 245, "protein_name": "Dehydrogenase/reductase SDR family member 6", "gene_name": "Bdh2", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 6 isoform 2", "refseq_ac": [ { "id": "NP_081484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081484", "type": "external" } ], "gene_names_uniprotkb": "Bdh2; Dhrs6", "gene_names_refseq": "1810026B04Rik; Bdh2; Dhrs6", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 6; (R)-beta-hydroxybutyrate dehydrogenase; 1.1.1.-; 1.1.1.104; 1.1.1.30; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1", "protein_names_refseq": "(R)-beta-hydroxybutyrate dehydrogenase; 4-oxo-L-proline reductase; R-beta-hydroxybutyrate dehydrogenase; dehydrogenase/reductase (SDR family) member 6; dehydrogenase/reductase SDR family member 6 isoform 2; oxidoreductase UCPA; short chain dehydrogenase/reductase family 15C member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69772); (R-MMU-77111)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20550936;21750661;24673886;24777603;24863067;30084848;35001849", "class_list": "", "function": "(Microbial infection) May play a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Host iron-siderophore complexes can be used by bacteria to promote their own growth and pathogenicity., [UniProtKB, PubMed]; 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation., [RefSeq, PubMed]; 3-hydroxybutyrate dehydrogenase-2 catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore., [RefSeq, PubMed]; NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (PubMed:20550936, PubMed:24777603, PubMed:24863067). May act as a 3-hydroxybutyrate dehydrogenase (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase., [UniProtKB, UniProtKB]; These findings demonstrate a key role for BDH2 in erythropoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0003858 3-hydroxybutyrate dehydrogenase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0016617 4-oxoproline reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0030855 epithelial cell differentiation;GO:0019290 siderophore biosynthetic process;GO:0042168 heme metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8JZV9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z222-1", "uniprot_id": [ { "id": "B3GN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z222", "type": "external" } ], "mass": 45883.0, "length": 397, "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2", "gene_name": "B3GNT2; B3gnt2", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2", "refseq_ac": [ { "id": "NP_001162585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162585", "type": "external" } ], "gene_names_uniprotkb": "B3GNT2; B3gnt2; B3gnt1; Beta3gnt", "gene_names_refseq": "B3Galt6; B3gnt1; B3gnt2; BGnT-1; BGnT-2; BGnT1; BGnT2; Beta3gnt", "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; 2.4.1.149; BGnT-1; BGnT-2; Beta-1,3-GalTase 7; Beta-1,3-Gn-T1; Beta-1,3-Gn-T2; Beta-1,3-N-acetylglucosaminyltransferase 1; Beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-galactosyltransferase 7; Beta-3-Gx-T7; Beta3Gal-T7; Beta3GalT7; Beta3Gn-T1; Beta3Gn-T2; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7; b3Gal-T7", "protein_names_refseq": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; beta-1,3-Gn-T1; beta-1,3-Gn-T2; beta-1,3-N-acetylglucosaminyltransferase 2; beta3Gn-T1; beta3Gn-T2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53625); (R-MMU-2022854); (R-MMU-913709)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11511811;17890318;18008318;18826941;19349973;21750661;22559903;23006775;24105809;31219806;34428180;36210013;9892646", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains (PubMed:9892646, PubMed:18826941). Probably constitutes the main polylactosamine synthase (PubMed:17890318)., [UniProtKB, PubMed, PubMed, PubMed]; Beta3GnT2(-/-) mice exhibit a relatively small deficit in their ability to discriminate divergent odors. Publication Status: Online-Only, [RefSeq, PubMed]; These data clearly suggest that GCNT2 functions in vivo together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension., [RefSeq, PubMed]; These results identify a novel function for beta3GnT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q91V18", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.149", "type": "external" }, { "id": "2.4.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.147", "type": "external" }, { "id": "2.4.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.146", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 1159, "hit_score": 2.0, "record_id": "Q9Z222-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14231-1", "uniprot_id": [ { "id": "AT1B2_MOUSE", "url": "https://www.uniprot.org/uniprot/P14231", "type": "external" } ], "mass": 33344.0, "length": 290, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-2", "gene_name": "Atp1b2", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-2", "refseq_ac": [ { "id": "NP_038201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038201", "type": "external" } ], "gene_names_uniprotkb": "Atp1b2", "gene_names_refseq": "Amog; Atp1b2; Atpb-2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-2; AMOG; Adhesion molecule in glia; Sodium/potassium-dependent ATPase subunit beta-2", "protein_names_refseq": "adhesion molecule in glia; glial cell adhesion molecule; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase subunit beta-2", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:11932); (R-MMU-210991); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12558975;1663071;1688561;1701244;19349973;21750661;26192747;30899004;31048931;31062247;33300544;34428180;40885482;7504672", "class_list": "", "function": "A functional link between the Na,K-ATPase beta2-subunit and Merlin/NF2 and suggest a role for the beta2-subunit in regulating cytoskeletal dynamics and Hippo/YAP signaling during neuronal differentiation, is reported., [RefSeq, PubMed]; Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB]; These and previous results led us to suggest an induced-fit binding mechanism for the interaction between retinoschisin and the Na/K-ATPase, which is dependent on threonine 240 in ATP1B2 allowing the accommodation of hyperflexible retinoschisin spikes by the associated protein-protein interaction patch on ATP1B2. Publication Status: Online-Only, [RefSeq, PubMed]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 39, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046982 protein heterodimerization activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097449 astrocyte projection;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1903976 negative regulation of glial cell migration;GO:0010976 positive regulation of neuron projection development;GO:0045494 photoreceptor cell maintenance;GO:0050821 protein stabilization;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 6.8, "record_id": "P14231-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08539-1", "uniprot_id": [ { "id": "BIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08539", "type": "external" } ], "mass": 64470.0, "length": 588, "protein_name": "Myc box-dependent-interacting protein 1", "gene_name": "Bin1", "organism": "Mouse", "refseq_name": "myc box-dependent-interacting protein 1 isoform 1", "refseq_ac": [ { "id": "NP_033798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033798", "type": "external" } ], "gene_names_uniprotkb": "Bin1; Amphl; Sh3p9", "gene_names_refseq": "ALP-1; Amphl; BRAMP-2; Bin1; SH3P9", "protein_names_uniprotkb": "Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1; SH3 domain-containing protein 9", "protein_names_refseq": "SH3 domain-containing protein 9; amphiphysin 2; amphiphysin II; amphiphysin-like protein; myc box-dependent-interacting protein 1 isoform 1; myc box-dependent-interacting protein 1", "tax_id": 10090, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220); prostate adenocarcinoma (Disease Ontology:DOID:2526); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:30948); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12183633;12456676;12668730;15345747;16452087;17114649;17242355;19131326;21183079;21750661;27179792;34428180;38664444;38724689;8782822;9182529;9630982", "class_list": "", "function": "BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts. Erratum:[Nat Commun. 2024 May 23;15(1):4397. doi: 10.1038/s41467-024-48944-4. PMID: 38782927] Publication Status: Online-Only, [RefSeq, PubMed]; BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation. Publication Status: Online-Only, [RefSeq, PubMed]; Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62434", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O08539-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08686-1", "uniprot_id": [ { "id": "BARX2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08686", "type": "external" } ], "mass": 31534.0, "length": 283, "protein_name": "Homeobox protein BarH-like 2", "gene_name": "Barx2", "organism": "Mouse", "refseq_name": "homeobox protein BarH-like 2", "refseq_ac": [ { "id": "NP_038828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038828", "type": "external" } ], "gene_names_uniprotkb": "Barx2", "gene_names_refseq": "2310006E12Rik; Barx2b; Barx2", "protein_names_uniprotkb": "Homeobox protein BarH-like 2", "protein_names_refseq": "homeobox protein BarH-like 2; homeodomain transcription factor BARX2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12486129;33069358;36210013;36965748;9122247", "class_list": "", "function": "PHLDA3 activated by BARX2 transcription, suppresses the malignant development of esophageal squamous cell carcinoma by downregulating PI3K/AKT levels., [RefSeq, PubMed]; Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells., [RefSeq, PubMed]; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZF9;Q921G1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001502 cartilage condensation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70201-1", "uniprot_id": [ { "id": "BIRC5_MOUSE", "url": "https://www.uniprot.org/uniprot/O70201", "type": "external" } ], "mass": 16298.0, "length": 140, "protein_name": "Baculoviral IAP repeat-containing protein 5", "gene_name": "Birc5", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001012273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012273", "type": "external" } ], "gene_names_uniprotkb": "Birc5; Api4; Iap4", "gene_names_refseq": "AAC-11; Api4; Birc5; TIAP; survivin40", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; TIAP", "protein_names_refseq": "apoptosis inhibitor 4; apoptosis inhibitor survivin; baculoviral IAP repeat-containing protein 5 isoform 3; baculoviral IAP repeat-containing protein 5; survivin", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); high grade glioma (Disease Ontology:DOID:3070); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11799)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10666222;10949038;19470789;20971978;22127645;22355372;25428506;25778398;29158846;30483475;37161052", "class_list": "", "function": "Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:25778398). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398)., [UniProtKB, UniProtKB, PubMed]; This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923F7;Q9WU53;Q9WU54", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70201-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70445-1", "uniprot_id": [ { "id": "BARD1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70445", "type": "external" } ], "mass": 84254.0, "length": 765, "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "Bard1", "organism": "Mouse", "refseq_name": "BRCA1-associated RING domain protein 1 isoform 1", "refseq_ac": [ { "id": "NP_031551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031551", "type": "external" } ], "gene_names_uniprotkb": "Bard1", "gene_names_refseq": "Bard1", "protein_names_uniprotkb": "BRCA1-associated RING domain protein 1; 2.3.2.27; BARD-1; RING-type E3 ubiquitin transferase BARD1", "protein_names_refseq": "BARD-1; BRCA1-associated RING domain protein 1 isoform 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:12021); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5689603); (R-MMU-5689901); (R-MMU-5693537); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 14, "publication_count": 7, "publication_id_list": "11779501;15077185;30760709;30874560;32730698;36852467;9798686", "class_list": "", "function": "Aberrant Zip14 expression in muscle is associated with cachexia in a Bard1-deficient mouse model of breast cancer metastasis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage., [UniProtKB, UniProtKB]; Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis, [RefSeq, PubMed]; Results demonstrate that endometriotic cells inhibit BARD1/BRCA1 function by upregulating miR-210-3p, which might be the underlying mechanism for endometriotic cell maintenance of growth in oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; Study reports that USP15 affects cancer cell response to PARP inhibitors by regulating homologous recombination repair. USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1. USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1gamma interaction, resulting in BRCA1/BARD1 retention at DSBs. Cancer-associated USP15 mutations, with decreased USP15-BARD1 interaction, increases PARP inhibitor sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2VCQ1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006281 DNA repair;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70445-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01887-1", "uniprot_id": [ { "id": "B2MG_MOUSE", "url": "https://www.uniprot.org/uniprot/P01887", "type": "external" } ], "mass": 13779.0, "length": 119, "protein_name": "Beta-2-microglobulin", "gene_name": "B2m", "organism": "Mouse", "refseq_name": "beta-2-microglobulin precursor", "refseq_ac": [ { "id": "NP_033865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033865", "type": "external" } ], "gene_names_uniprotkb": "B2m", "gene_names_refseq": "B2m; Ly-m11; beta2-m; beta2m", "protein_names_uniprotkb": "Beta-2-microglobulin", "protein_names_refseq": "beta-2-microglobulin precursor", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); peripheral artery disease (Disease Ontology:DOID:0050830); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); immunodeficiency 43 (Disease Ontology:DOID:0111981); hypertension (Disease Ontology:DOID:10763); pyelonephritis (Disease Ontology:DOID:11400); Parkinson's disease (Disease Ontology:DOID:14330); arteriosclerosis (Disease Ontology:DOID:2349); hemochromatosis (Disease Ontology:DOID:2352); acute kidney failure (Disease Ontology:DOID:3021); carotid artery disease (Disease Ontology:DOID:3407); autoimmune disease (Disease Ontology:DOID:417); ureteral obstruction (Disease Ontology:DOID:5199); proteinuria (Disease Ontology:DOID:576); encephalomyelitis (Disease Ontology:DOID:640); cataract (Disease Ontology:DOID:83); arthritis (Disease Ontology:DOID:848); measles (Disease Ontology:DOID:8622); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12010); (R-MMU-1236974); (R-MMU-1236977); (R-MMU-198933); (R-MMU-2172127); (R-MMU-2424491); (R-MMU-6798695); (R-MMU-983170)", "pathway_count": 8, "publication_count": 28, "publication_id_list": "1323877;17322886;18250455;20173027;25605945;28011936;31219806;31599954;32152506;34203471;34428180;3510743;35820727;35984892;36288343;37453647;37828378;39627609;59595;6165997;6166005;6180834;6354707;7506996;8482575;9192660;9707606;9729040", "class_list": "glycogene", "function": "Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XJ8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0023026 MHC class II protein complex binding;GO:0005198 structural molecule activity;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P01887-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21237-1", "uniprot_id": [ { "id": "BDNF_MOUSE", "url": "https://www.uniprot.org/uniprot/P21237", "type": "external" } ], "mass": 28123.0, "length": 249, "protein_name": "Neurotrophic factor BDNF precursor form", "gene_name": "Bdnf", "organism": "Mouse", "refseq_name": "neurotrophic factor BDNF precursor form isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001041604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041604", "type": "external" } ], "gene_names_uniprotkb": "Bdnf", "gene_names_refseq": "Bdnf", "protein_names_uniprotkb": "Neurotrophic factor BDNF precursor form; Brain-derived neurotrophic factor; proBDNF", "protein_names_refseq": "neurotrophic factor BDNF precursor form isoform 2 preproprotein; neurotrophic factor BDNF precursor form; proBDNF", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); keratoconus (Disease Ontology:DOID:10126); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); trigeminal neuralgia (Disease Ontology:DOID:12098); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); color blindness (Disease Ontology:DOID:13399); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); premature ejaculation (Disease Ontology:DOID:13709); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); major depressive disorder (Disease Ontology:DOID:1470); urticaria (Disease Ontology:DOID:1555); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); intestinal disease (Disease Ontology:DOID:5295); acute stress disorder (Disease Ontology:DOID:6088); amphetamine abuse (Disease Ontology:DOID:670); retinal degeneration (Disease Ontology:DOID:8466); vascular dementia (Disease Ontology:DOID:8725); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypertensive encephalopathy (Disease Ontology:DOID:9427); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); irritable bowel syndrome (Disease Ontology:DOID:9778); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:12064); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9026527); (R-MMU-9028731); (R-MMU-9032759)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15486301;17023662;17149751;21750661;2369898;23785138;24908487;25428506;27457814;28111162;29909994;7957235;8139657", "class_list": "", "function": "Distinct tissue-specific expression profiles of each of mouse 5' exon-specific transcripts in different brain regions and nonneural tissues., [RefSeq, PubMed]; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS., [UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) (PubMed:27457814). Binding to NGFR and SORCS2 promotes neuronal apoptosis (PubMed:24908487). Promotes neuronal growth cone collapse (PubMed:24908487, PubMed:27457814)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse., [UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 67, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AII2;Q8CCH9", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005169 neurotrophin TRKB receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046668 regulation of retinal cell programmed cell death;GO:0061193 taste bud development;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0042490 mechanoreceptor differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P21237-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32299-1", "uniprot_id": [ { "id": "BKRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P32299", "type": "external" } ], "mass": 44389.0, "length": 392, "protein_name": "B2 bradykinin receptor", "gene_name": "Bdkrb2", "organism": "Mouse", "refseq_name": "B2 bradykinin receptor", "refseq_ac": [ { "id": "NP_033877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033877", "type": "external" } ], "gene_names_uniprotkb": "Bdkrb2", "gene_names_refseq": "B(2); B2R; B2; BK-2; BK2R; BK2; BKR2; BRB2; Bdkrb2", "protein_names_uniprotkb": "B2 bradykinin receptor; B2R; BK-2 receptor", "protein_names_refseq": "B2 bradykinin receptor; BK-2 receptor; kinin B2", "tax_id": 10090, "disease": "pleurisy (Disease Ontology:DOID:10247); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:12062); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "25428506;30084848;34428180;36210013;36641883;37464053;38338764;7959003;8166739;8302267;8394991;8652530", "class_list": "", "function": "Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice. Publication Status: Online-Only, [RefSeq, PubMed]; In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant., [RefSeq, PubMed]; Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors., [RefSeq, PubMed]; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EHE3", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0002020 protease binding;GO:0046982 protein heterodimerization activity;GO:0031702 type 1 angiotensin receptor binding;GO:0004947 bradykinin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008285 negative regulation of cell population proliferation;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32299-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38649-1", "uniprot_id": [ { "id": "BGAT_MOUSE", "url": "https://www.uniprot.org/uniprot/P38649", "type": "external" } ], "mass": 38777.0, "length": 332, "protein_name": "Histo-blood group ABO system transferase", "gene_name": "Abo", "organism": "Mouse", "refseq_name": "histo-blood group ABO system transferase isoform b", "refseq_ac": [ { "id": "NP_001277373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277373", "type": "external" } ], "gene_names_uniprotkb": "Abo", "gene_names_refseq": "Abo; NAGAT", "protein_names_uniprotkb": "Histo-blood group ABO system transferase; 2.4.1.37; 2.4.1.40; A transferase; B transferase; Cis-AB transferase; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Histo-blood group A transferase; Histo-blood group B transferase; NAGAT", "protein_names_refseq": "ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); cis-AB transferase; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase isoform b; histo-blood group ABO system transferase; histo-blood group B transferase", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); hypertension (Disease Ontology:DOID:10763); leukemia (Disease Ontology:DOID:1240); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); echinococcosis (Disease Ontology:DOID:1496); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis (Disease Ontology:DOID:2237); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); gallbladder carcinoma (Disease Ontology:DOID:4948); pneumonia (Disease Ontology:DOID:552); hemolytic anemia (Disease Ontology:DOID:583); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:80908); (R-MMU-9033807)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11278752;21750661;25428506;7523108", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of N-acetyl-alpha-D-galactosamine (GalNAc) or galactose (Gal) in an alpha1,3 linkage to the terminal Gal of H antigens to form A and B antigens., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AL98;Q8BZH3;Q8BZQ6;Q9EQW2;Q9EQW3", "ec_number_list": [ { "id": "2.4.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.37", "type": "external" }, { "id": "2.4.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.40", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0000166 nucleotide binding;GO:0003823 antigen binding;GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity;GO:0004381 fucosylgalactoside 3-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0016020 membrane", "go_biological_process": "GO:0009312 oligosaccharide biosynthetic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 1051, "hit_score": 0.5, "record_id": "P38649-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48985-1", "uniprot_id": [ { "id": "ATOH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48985", "type": "external" } ], "mass": 37854.0, "length": 351, "protein_name": "Transcription factor Atoh1", "gene_name": "Atoh1", "organism": "Mouse", "refseq_name": "transcription factor Atoh1", "refseq_ac": [ { "id": "NP_031526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031526", "type": "external" } ], "gene_names_uniprotkb": "Atoh1; Ath1", "gene_names_refseq": "Atoh1; Hath1; MATH-1; Math1; bHLHa14", "protein_names_uniprotkb": "Transcription factor Atoh1; Atonal bHLH transcription factor 1; Helix-loop-helix protein mATH-1; Protein atonal homolog 1; mATH1", "protein_names_refseq": "helix-loop-helix protein mATH-1; protein atonal homolog 1; transcription factor Atoh1", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 89 (Disease Ontology:DOID:0070612)", "pathway": " (mmu:11921)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10648228;17977745;7721778", "class_list": "", "function": "Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0014014 negative regulation of gliogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48985-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56384-1", "uniprot_id": [ { "id": "AT5G3_MOUSE", "url": "https://www.uniprot.org/uniprot/P56384", "type": "external" } ], "mass": 14745.0, "length": 141, "protein_name": "ATP synthase F(0) complex subunit C3, mitochondrial", "gene_name": "Atp5mc3", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor", "refseq_ac": [ { "id": "NP_001288650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288650", "type": "external" } ], "gene_names_uniprotkb": "Atp5mc3; Atp5g3", "gene_names_refseq": "6030447M23; Atp5g3; Atp5mc3", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C3, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 3; ATP synthase proteolipid P3; ATPase protein 9; ATPase subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor; ATP synthase F(0) complex subunit C3, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P3; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9); ATPase protein 9; ATPase subunit c", "tax_id": 10090, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143)", "pathway": " (mmu:228033); (R-MMU-1268020); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "24085430;26495903;30530489", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]; The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]; We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0045471 response to ethanol;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56384-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58158-1", "uniprot_id": [ { "id": "B3GA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58158", "type": "external" } ], "mass": 37067.0, "length": 335, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "gene_name": "B3gat3", "organism": "Mouse", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "refseq_ac": [ { "id": "NP_077218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077218", "type": "external" } ], "gene_names_uniprotkb": "B3gat3", "gene_names_refseq": "2810405M13Rik; B3gat3", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; 2.4.1.135; Beta-1,3-glucuronyltransferase 3; GlcAT-I; GlcUAT-I; Glucuronosyltransferase I; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase", "protein_names_refseq": "UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; glcAT-I; glcUAT-I; glucuronosyltransferase I; glucuronyltransferase I", "tax_id": 10090, "disease": "Larsen-like syndrome B3GAT3 type (Disease Ontology:DOID:0080575)", "pathway": " (mmu:72727); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20164174;21750661;21763480;30084848;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation., [UniProtKB, UniProtKB]; Mice with a deletion of GlcAT-I showed remarkable reduction of the synthesis of chondroitin sulfate and heparan sulfate and embryonic lethality before the 8-cell stage because of failed cytokinesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0005975 carbohydrate metabolic process;GO:0043085 positive regulation of catalytic activity;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P58158-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59270-1", "uniprot_id": [ { "id": "B3GA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P59270", "type": "external" } ], "mass": 37132.0, "length": 324, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2", "gene_name": "B3gat2", "organism": "Mouse", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor", "refseq_ac": [ { "id": "NP_742122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742122", "type": "external" } ], "gene_names_uniprotkb": "B3gat2; Glcats", "gene_names_refseq": "B3gat2; GlcAT-S; Glcats", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; 2.4.1.135; Beta-1,3-glucuronyltransferase 2; GlcAT-D; GlcAT-S; Glucuronosyltransferase S; UDP-glucuronosyltransferase S", "protein_names_refseq": "UDP-glucuronosyltransferase-S; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; glcAT-D; glucuronosyltransferase S", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:280645); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12383500;17935701;21750661", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins., [UniProtKB]; Moderate expression of GlcAT-S were seen in neuronal cells of several nuclei of limbic-related regions, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.9, "record_id": "P59270-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63157-1", "uniprot_id": [ { "id": "BARH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63157", "type": "external" } ], "mass": 35136.0, "length": 327, "protein_name": "BarH-like 1 homeobox protein", "gene_name": "Barhl1", "organism": "Mouse", "refseq_name": "barH-like 1 homeobox protein isoform a", "refseq_ac": [ { "id": "NP_001157658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157658", "type": "external" } ], "gene_names_uniprotkb": "Barhl1; Bhx1; Mbh2", "gene_names_refseq": "Barhl1; Dres115; MBH2", "protein_names_uniprotkb": "BarH-like 1 homeobox protein; Bar-class homeodomain protein MBH2; BarH-related homeobox protein 1", "protein_names_refseq": "bar-class homeodomain protein MBH2; barH-like 1 homeobox protein isoform a; barH-like 1 homeobox protein; barH-related homeobox protein 1", "tax_id": 10090, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); Alzheimer's disease (Disease Ontology:DOID:10652); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:54422)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10814725;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK26", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63157-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97370-1", "uniprot_id": [ { "id": "AT1B3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97370", "type": "external" } ], "mass": 31776.0, "length": 278, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-3", "gene_name": "Atp1b3", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-3 isoform 1", "refseq_ac": [ { "id": "NP_031528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031528", "type": "external" } ], "gene_names_uniprotkb": "Atp1b3", "gene_names_refseq": "ATPB-3; Atp1b3", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-3; ATPB-3; Sodium/potassium-dependent ATPase subunit beta-3", "protein_names_refseq": "ATPase, Na+/K+ beta 3 polypeptide; Na K-ATPase beta-3 subunit; sodium/potassium-dependent ATPase subunit beta-3; sodium/potassium-transporting ATPase subunit beta-3 isoform 1; sodium/potassium-transporting ATPase subunit beta-3", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:11933); (R-MMU-210991); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;26495903;30899004;33300544;34428180;9003452", "class_list": "", "function": "This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0050821 protein stabilization;GO:0006883 intracellular sodium ion homeostasis;GO:0006813 potassium ion transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97370-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98063-1", "uniprot_id": [ { "id": "BMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P98063", "type": "external" } ], "mass": 111666.0, "length": 991, "protein_name": "Bone morphogenetic protein 1", "gene_name": "Bmp1", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033885", "type": "external" } ], "gene_names_uniprotkb": "Bmp1", "gene_names_refseq": "Bmp1; Pcp; Tld", "protein_names_uniprotkb": "Bone morphogenetic protein 1; 3.4.24.19; BMP-1; Mammalian tolloid protein; PCP; Procollagen C-proteinase; mTld", "protein_names_refseq": "bone morphogenetic protein 1 isoform 1 precursor; mammalian tolloid protein; procollagen C-proteinase", "tax_id": 10090, "disease": "osteogenesis imperfecta type 13 (Disease Ontology:DOID:0110342); osteogenesis imperfecta (Disease Ontology:DOID:12347)", "pathway": " (mmu:12153); (R-MMU-1650814); (R-MMU-2214320); (R-MMU-2243919); (R-MMU-8963896)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20181949;21750661;24419319;28068493;37235726;37828378;38216590;38369459;8174772;8951074", "class_list": "", "function": "Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:24419319, PubMed:28068493, PubMed:8951074). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:20181949). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1[+/-] mouse model of craniosynostosis. Publication Status: Online-Only, [RefSeq, PubMed]; Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases., [RefSeq, PubMed]; This gene encodes a metalloproteinase that plays an essential role in the formation of the extracellular matrix and is also able to induce ectopic bone formation. Unlike other bone morphogenetic proteins, the protein encoded by this gene is not closely related to transforming growth factor-beta. This protein plays in role several developmental processes. In humans, mutations in this gene are associated with osteogenesis imperfecta and with increased bone mineral density and multiple recurrent fractures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZM2", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.14", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0031982 vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0001503 ossification;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P98063-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09199-1", "uniprot_id": [ { "id": "B4GN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09199", "type": "external" } ], "mass": 58317.0, "length": 510, "protein_name": "Beta-1,4 N-acetylgalactosaminyltransferase 2", "gene_name": "B4galnt2", "organism": "Mouse", "refseq_name": "beta-1,4 N-acetylgalactosaminyltransferase 2", "refseq_ac": [ { "id": "NP_032107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032107", "type": "external" } ], "gene_names_uniprotkb": "B4galnt2; Galgt2; Ggm3", "gene_names_refseq": "B4galnt2; Dlb-1; Dlb1; Galg2; Galgt2; Ggm3; Igf2bp1", "protein_names_uniprotkb": "Beta-1,4 N-acetylgalactosaminyltransferase 2; 2.4.1.-", "protein_names_refseq": "CT-Gal NAc transferase; N-acetylgalactosaminyltransferase; UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)- galactosyl-N-acetylglucosaminylpolypeptide-beta-1, 4-N-acetylgalactosaminyltransferase; beta-1,4 N-acetylgalactosaminyltransferase 2; dolichos lectin binding 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14422); (R-MMU-446203); (R-MMU-9037629)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26435413;28806915;30084848;7515051", "class_list": "glycogene;glycosyltransferase", "function": "B4galnt2 displays an interesting spatial allelic distribution in Western Europe, likely due to the recent action of natural selection. Publication Status: Online-Only, [RefSeq, PubMed]; Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of T-lymphocyte CT glycan antigen carried by CD45 family of protein phosphatases. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form GalNAcbeta1->4(NeuAcalpha2->3)Gal-R glycan epitope., [UniProtKB, PubMed, UniProtKB]; Overexpression of Galgt2 failed to inhibit skeletal muscle pathology in dystroglycan-deficient muscles, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0047233 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0009101 glycoprotein biosynthetic process;GO:0022408 negative regulation of cell-cell adhesion;GO:0017038 protein import;GO:0006047 UDP-N-acetylglucosamine metabolic process", "synthesized_glycan_count": 72, "hit_score": 0.5, "record_id": "Q09199-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KI9-1", "uniprot_id": [ { "id": "ARSI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32KI9", "type": "external" } ], "mass": 64367.0, "length": 573, "protein_name": "Arylsulfatase I", "gene_name": "Arsi", "organism": "Mouse", "refseq_name": "arylsulfatase I precursor", "refseq_ac": [ { "id": "NP_001033588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033588", "type": "external" } ], "gene_names_uniprotkb": "Arsi", "gene_names_refseq": "Arsi", "protein_names_uniprotkb": "Arylsulfatase I; 3.1.6.-; ASI", "protein_names_refseq": "ASI; arylsulfatase I precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:545260); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16174644", "class_list": "glycogene", "function": "Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32KI9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZW7-1", "uniprot_id": [ { "id": "BEX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZW7", "type": "external" } ], "mass": 13353.0, "length": 114, "protein_name": "Protein BEX6", "gene_name": "Bex6", "organism": "Mouse", "refseq_name": "protein BEX6", "refseq_ac": [ { "id": "NP_001028711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028711", "type": "external" } ], "gene_names_uniprotkb": "Bex6", "gene_names_refseq": "B020003O03Rik; Bex6", "protein_names_uniprotkb": "Protein BEX6; Brain-expressed X-linked protein 6 homolog", "protein_names_refseq": "brain expressed gene 6; brain expressed, X-linked 6; brain-expressed X-linked protein 6 homolog; protein BEX6", "tax_id": 10090, "disease": "", "pathway": " (mmu:328660)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15958283", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSJ0", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0042127 regulation of cell population proliferation;GO:0030334 regulation of cell migration;GO:1904428 negative regulation of tubulin deacetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TZW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJB0-1", "uniprot_id": [ { "id": "BHA09_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RJB0", "type": "external" } ], "mass": 25115.0, "length": 231, "protein_name": "Class A basic helix-loop-helix protein 9", "gene_name": "Bhlha9", "organism": "Mouse", "refseq_name": "class A basic helix-loop-helix protein 9", "refseq_ac": [ { "id": "NP_796156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796156", "type": "external" } ], "gene_names_uniprotkb": "Bhlha9; Bhlhf42", "gene_names_refseq": "A830053O21Rik; Bhlha9; Fingerin", "protein_names_uniprotkb": "Class A basic helix-loop-helix protein 9; Class B basic helix-loop-helix factor 42; bHLHa9; bHLHf42", "protein_names_refseq": "bHLHf42; class A basic helix-loop-helix protein 9; class B basic helix-loop-helix factor 42; novel helix-loop-helix DNA-binding domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320522)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22147889;24852374;28324176;31968239", "class_list": "", "function": "Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner., [RefSeq, PubMed]; Results show that Fingerin gene dosage links two different congenital limb malformations, syndactyly and ectrodactyly, which were previously postulated to share a common etiology., [RefSeq, PubMed]; That Bhlha9 regulates apical ectodermal ridge formation during limb/finger development., [RefSeq, PubMed]; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZL8;Q8BLP5", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RJB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U5M8-1", "uniprot_id": [ { "id": "BL1S3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U5M8", "type": "external" } ], "mass": 20398.0, "length": 195, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 3", "gene_name": "Bloc1s3", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 3", "refseq_ac": [ { "id": "NP_808360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808360", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s3; Blos3; Rp", "gene_names_refseq": "Bloc1s3; Blos3; E230011O18; rp", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 3; BLOC-1 subunit 3; Reduced pigmentation protein", "protein_names_refseq": "Bloc-1 complex component; Bloc1 subunit 3; biogenesis of lysosome-related organelles complex 1 subunit 3; biogenesis of lysosome-related organelles complex-1, subunit 3; reduced pigmentation protein", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 8 (Disease Ontology:DOID:0060546)", "pathway": " (mmu:232946); (R-MMU-432722)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15102850;15265785;16760431;17182842;19546860;21183079;21998198", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6R4;Q8R0Z3", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0031175 neuron projection development;GO:0007596 blood coagulation;GO:0030168 platelet activation;GO:0060155 platelet dense granule organization;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5U5M8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6E1M8-1", "uniprot_id": [ { "id": "AWAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6E1M8", "type": "external" } ], "mass": 38145.0, "length": 333, "protein_name": "Acyl-CoA wax alcohol acyltransferase 2", "gene_name": "Awat2", "organism": "Mouse", "refseq_name": "acyl-CoA wax alcohol acyltransferase 2 isoform 2", "refseq_ac": [ { "id": "NP_001277324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277324", "type": "external" } ], "gene_names_uniprotkb": "Awat2; Dgat2l4; Ws", "gene_names_refseq": "9430062J17Rik; ARAT; Awat2; Dgat2l4; WS", "protein_names_uniprotkb": "Acyl-CoA wax alcohol acyltransferase 2; 11-cis-RE-synthase; 11-cis-specific retinyl-ester synthase; 2.3.1.20; 2.3.1.75; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diacylglycerol O-acyltransferase 2-like protein 4; Long-chain-alcohol O-fatty-acyltransferase 2; Retinol O-fatty-acyltransferase; Wax synthase; mWS", "protein_names_refseq": "11-cis-RE-synthase; 11-cis-specific retinyl-ester synthase; acyl-CoA retinol O-fatty-acyltransferase; acyl-CoA wax alcohol acyltransferase 2 isoform 2; diacylglycerol O-acyltransferase 2-like protein 4; long-chain-alcohol O-fatty-acyltransferase 2; wax synthase 2", "tax_id": 10090, "disease": "dry eye syndrome (Disease Ontology:DOID:10140)", "pathway": " (mmu:245532); (R-MMU-1482883); (R-MMU-2187335); (R-MMU-9640463)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "15220349;24799687;26714272;28096191;35820727", "class_list": "", "function": "Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donor and acceptor, respectively (PubMed:15220349). Also possesses fatty acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells (PubMed:28096191). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13- cis-retinol and all-trans-retinol substrates., [UniProtKB, PubMed, PubMed]; Hese data provide the experimental basis for understanding regulation of AWAT2 substrate specificity., [RefSeq, PubMed]; Transmembrane Domains Exclude Very Long Chain Fatty acyl-CoAs from the Active Site of Mouse Wax Synthase Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM49", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010025 wax biosynthetic process;GO:0006640 monoacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6E1M8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6HA09-1", "uniprot_id": [ { "id": "ASTL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6HA09", "type": "external" } ], "mass": 47455.0, "length": 435, "protein_name": "Astacin-like metalloendopeptidase", "gene_name": "Astl", "organism": "Mouse", "refseq_name": "astacin-like metalloendopeptidase isoform a precursor", "refseq_ac": [ { "id": "NP_001277932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277932", "type": "external" } ], "gene_names_uniprotkb": "Astl; Sas1b", "gene_names_refseq": "7420700F21; Astl; Sas1b", "protein_names_uniprotkb": "Astacin-like metalloendopeptidase; 3.4.-.-; Oocyte astacin; Ovastacin; Sperm acrosomal SLLP1-binding protein", "protein_names_refseq": "astacin-like metalloendopeptidase (M12 family); astacin-like metalloendopeptidase isoform a precursor; oocyte astacin; ovastacin; sperm acrosomal SLLP1-binding protein; sperm acrosomal SLLP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215095)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15087446;21750661;22206759;22275110;22472438;30808003;37133443", "class_list": "", "function": "ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development., [RefSeq, PubMed]; Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects., [RefSeq, PubMed]; Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity., [RefSeq, PubMed]; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding., [UniProtKB, PubMed, PubMed]; Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AHU0;A2AHU1;G7Z016;G7Z017;G7Z018;G7Z019;Q8BMA1", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity;GO:0070001 aspartic-type peptidase activity;GO:0070002 glutamic-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0060473 cortical granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0009566 fertilization;GO:0010954 positive regulation of protein processing;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6HA09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9S1-1", "uniprot_id": [ { "id": "ATMIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9S1", "type": "external" } ], "mass": 87424.0, "length": 818, "protein_name": "ATM interactor", "gene_name": "Atmin", "organism": "Mouse", "refseq_name": "ATM interactor", "refseq_ac": [ { "id": "NP_808368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808368", "type": "external" } ], "gene_names_uniprotkb": "Atmin; Kiaa0431", "gene_names_refseq": "Asciz; Atmin; gpg6; mKIAA0431", "protein_names_uniprotkb": "ATM interactor; ASCIZ; ATM/ATR-substrate CHK2-interacting zinc finger protein", "protein_names_refseq": "ASCIZ; ATM interactor; ATM/ATR-substrate CHEK2-interacting zinc finger protein; ATM/ATR-substrate CHK2-interacting zinc finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:234776)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17525732;20889973;20975950;22167198;27581360;28648892;28922373;30414501;31481498;33109704;34428180", "class_list": "", "function": "ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN., [RefSeq, PubMed]; ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage., [RefSeq, PubMed]; ATMIN, therefore, has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging., [RefSeq, PubMed]; Data indicate that, in addition to its role in the DNA base damage response, ASCIZ has separate developmental functions as an essential regulator of respiratory organogenesis. GeneRIF: Asciz is essential for mouse embryonic development and lung organogenesis likely as a transcription factor GeneRIF: Absence of Asciz (Atmin) leads to increased oxidative and methylating DNA base damage sensitivity in primary fibroblasts GeneRIF: Asciz (Atmin) deletion or knock-down does not affect ATM levels and activation in mouse, chicken, or human cells Erratum:[PLoS Genet. 2010;6(11). doi: 10.1371/annotation/bce92e15-60b4-493b-89de-28529386f4ac] Publication Status: Online-Only, [RefSeq, PubMed]; Heterozygous Atmin deletion significantly increased tumor cell proliferation, tumor burden, and tumor grade in the LSL-KRasG12D; Trp53 F/F (KP) mouse model of lung adenocarcinoma, identifying ATMIN as a haploinsufficient tumor suppressor. ATMIN-deficient KP lung tumor cells showed increased survival in response to replication stress and consequently accumulated DNA damage., [RefSeq, PubMed]; Oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas. Publication Status: Online-Only, [RefSeq, PubMed]; This work indicates a novel role for non-canonical Wnt/planar cell polarity signalling in Autosomal Recessive Polycystic Kidney Disease and suggests ATMIN as a modulator of PKHD1., [RefSeq, PubMed]; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05CB1;Q80U05;Q8C311", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070840 dynein complex binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P9S1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811C2-1", "uniprot_id": [ { "id": "ATG4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811C2", "type": "external" } ], "mass": 52056.0, "length": 458, "protein_name": "Cysteine protease ATG4C", "gene_name": "Atg4c", "organism": "Mouse", "refseq_name": "cysteine protease ATG4C", "refseq_ac": [ { "id": "NP_001139439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139439", "type": "external" } ], "gene_names_uniprotkb": "Atg4c; Apg4c; Autl3", "gene_names_refseq": "Apg4-C; Apg4c; Atg4cl; Atg4c; Autl1", "protein_names_uniprotkb": "Cysteine protease ATG4C; 3.4.22.-; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C", "protein_names_refseq": "APG4 (ATG4) autophagy-related homolog C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin 3; autophagy-related 4C; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C; cysteine protease ATG4C; cysteine protease involved in autophagy", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:242557); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12446702;17442669;22753949;25428506;31219806;34428180;35820727;37459465", "class_list": "", "function": "Analysis of ATG4C function in vivo., [RefSeq, PubMed]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We demonstrated for the first time that triggering of TRPV1 induces autophagy in mouse thymocytes resulting in AMPK activation and increased Atg4C mRNA expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASJ9;Q6PD25", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q811C2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGV7-1", "uniprot_id": [ { "id": "BACD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGV7", "type": "external" } ], "mass": 36442.0, "length": 329, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "gene_name": "Kctd13", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "refseq_ac": [ { "id": "NP_766335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766335", "type": "external" } ], "gene_names_uniprotkb": "Kctd13; Poldip1", "gene_names_refseq": "1500003N18Rik; Kctd13; PDIP1alpha; Pdip1; Poldip1", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; Polymerase delta-interacting protein 1", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; polymerase delta-interacting protein 1; tumor necrosis factor alpha-inducible protein PDIP1", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:233877); (R-MMU-9696264); (R-MMU-9696270)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15757666;16239304;22596160;26969432;29088697;30084848;36196997;37142655;38489388", "class_list": "", "function": "Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function., [RefSeq, PubMed]; KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13., [RefSeq, PubMed]; Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate, [RefSeq, PubMed]; PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages., [RefSeq, PubMed]; Promoter of the mouse polymerase delta-interacting protein 1 gene (PDIP1) was characterized; it is regulated by the AP-2 and Sp-1 transcription factors., [RefSeq, PubMed]; Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:29088697). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697). Mediates also the ubiquitination and degradation of GluN1/GRIN1 to regulate excitatory synaptic transmission and seizure susceptibility (PubMed:37142655)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXE9", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0016477 cell migration;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGV7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGW3-1", "uniprot_id": [ { "id": "BHE23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGW3", "type": "external" } ], "mass": 23701.0, "length": 223, "protein_name": "Class E basic helix-loop-helix protein 23", "gene_name": "Bhlhe23", "organism": "Mouse", "refseq_name": "class E basic helix-loop-helix protein 23", "refseq_ac": [ { "id": "NP_542372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542372", "type": "external" } ], "gene_names_uniprotkb": "Bhlhe23; Bhlhb4; H20", "gene_names_refseq": "A930001L02Rik; BETA4; Beta3b; Bhlhb4; Bhlhe23", "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 23; Class B basic helix-loop-helix protein 4; bHLHb4; bHLHe23", "protein_names_refseq": "basic helix-loop-helix domain containing, class B4; beta-cell E-box transactivating factor 4; class B basic helix-loop-helix protein 4; class E basic helix-loop-helix protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:140489)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11863370;15363390", "class_list": "", "function": "BHLHB4 may modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types., [RefSeq, PubMed]; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q71MB7", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046548 retinal rod cell development;GO:0048050 post-embryonic eye morphogenesis;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGY6-1", "uniprot_id": [ { "id": "B3GN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGY6", "type": "external" } ], "mass": 43914.0, "length": 376, "protein_name": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "gene_name": "B3gnt5", "organism": "Mouse", "refseq_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "refseq_ac": [ { "id": "NP_001152879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152879", "type": "external" } ], "gene_names_uniprotkb": "B3gnt5", "gene_names_refseq": "B3gnt5; beta3GnT5", "protein_names_uniprotkb": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; 2.4.1.206; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5", "protein_names_refseq": "BGnT-5; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-Gn-T5; beta-1,3-N-acetylglucosaminyltransferase 5; beta3Gn-T5; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; lactotriaosylceramide synthase; lc(3)Cer synthase; lc3 synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:108105); (R-MMU-913709); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11283017;11384981;19014510;21087515;30084848;30779550;34428180", "class_list": "glycogene;glycosyltransferase", "function": "B3gnt5 is essential to pre-implantation development of the murine embryo. Publication Status: Online-Only, [RefSeq, PubMed]; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development., [UniProtKB, PubMed]; Results demonstrate that Lc3 synthase and lacto-neolacto series gangliosides are essential to multiple physiological functions, especially the control of reproductive output, and spleen B-cell abnormality. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810C6;Q923K7", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.149", "type": "external" }, { "id": "2.4.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.147", "type": "external" }, { "id": "2.4.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.146", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 545, "hit_score": 1.1, "record_id": "Q8BGY6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4A5-1", "uniprot_id": [ { "id": "ASXL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4A5", "type": "external" } ], "mass": 243673.0, "length": 2259, "protein_name": "Putative Polycomb group protein ASXL3", "gene_name": "Asxl3", "organism": "Mouse", "refseq_name": "putative Polycomb group protein ASXL3", "refseq_ac": [ { "id": "NP_001161249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161249", "type": "external" } ], "gene_names_uniprotkb": "Asxl3", "gene_names_refseq": "Asxl3; C230079D11Rik; D430002O22Rik; D930044O18Rik; Gm329; Gm945", "protein_names_uniprotkb": "Putative Polycomb group protein ASXL3; Additional sex combs-like protein 3", "protein_names_refseq": "additional sex combs like 3, transcriptional regulator; additional sex combs-like protein 3; polycomb group protein; putative Polycomb group protein ASXL3", "tax_id": 10090, "disease": "Bainbridge-Ropers syndrome (Disease Ontology:DOID:0080893)", "pathway": " (mmu:211961)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16412590;21750661;25428506;32747411;35820727", "class_list": "", "function": "Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes (PubMed:32747411)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C380", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042975 peroxisome proliferator activated receptor binding", "go_cellular_component": "GO:0035517 PR-DUB complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009887 animal organ morphogenesis;GO:0051055 negative regulation of lipid biosynthetic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C4A5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C9S8-1", "uniprot_id": [ { "id": "ATG4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C9S8", "type": "external" } ], "mass": 45095.0, "length": 396, "protein_name": "Cysteine protease ATG4A", "gene_name": "Atg4a", "organism": "Mouse", "refseq_name": "cysteine protease ATG4A isoform 1", "refseq_ac": [ { "id": "NP_777364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777364", "type": "external" } ], "gene_names_uniprotkb": "Atg4a; Apg4a; Autl2", "gene_names_refseq": "Apg4a; Atg4al; Atg4a; Autl2", "protein_names_uniprotkb": "Cysteine protease ATG4A; 3.4.22.-; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A", "protein_names_refseq": "APG4 (ATG4) autophagy-related homolog A; AUT-like 2, cysteine endopeptidase; autophagin 2; autophagy 4 homolog A; autophagy-related 4A; autophagy-related cysteine endopeptidase 2; autophagy-related protein 4 homolog A; cysteine protease APG4A; cysteine protease ATG4A isoform 1; cysteine protease ATG4A", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:666468); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12446702;21750661", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811B8", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0015031 protein transport;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C9S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDM1-1", "uniprot_id": [ { "id": "ATAD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDM1", "type": "external" } ], "mass": 117943.0, "length": 1040, "protein_name": "ATPase family AAA domain-containing protein 2", "gene_name": "Atad2", "organism": "Mouse", "refseq_name": "ATPase family AAA domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_081711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081711", "type": "external" } ], "gene_names_uniprotkb": "Atad2", "gene_names_refseq": "2610509G12Rik; Atad2", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 2; 3.6.1.-", "protein_names_refseq": "ATPase family AAA domain-containing protein 2 isoform 1; ATPase family AAA domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70472); (R-MMU-8866910)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "16479539;21183079;21750661;22872234;23038103;25428506;25605945;28528544;30084848;31219806;31747529;34203471;34428180;34580178;34887587;35085891;35820727;36210013", "class_list": "", "function": "ATAD2 controls chromatin-bound HIRA turnover. Publication Status: Online-Only, [RefSeq, PubMed]; ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors., [RefSeq, PubMed]; Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway., [RefSeq, PubMed]; EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development., [RefSeq, PubMed]; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYW6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CDM1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHH5-1", "uniprot_id": [ { "id": "BICRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHH5", "type": "external" } ], "mass": 114350.0, "length": 1074, "protein_name": "BRD4-interacting chromatin-remodeling complex-associated protein-like", "gene_name": "Bicral", "organism": "Mouse", "refseq_name": "BRD4-interacting chromatin-remodeling complex-associated protein-like", "refseq_ac": [ { "id": "NP_001093922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093922", "type": "external" } ], "gene_names_uniprotkb": "Bicral; Gltscr1l; Kiaa0240", "gene_names_refseq": "Bicral; Gltscr1l; mKIAA0240", "protein_names_uniprotkb": "BRD4-interacting chromatin-remodeling complex-associated protein-like", "protein_names_refseq": "BRD4-interacting chromatin-remodeling complex-associated protein-like; GLTSCR1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:210982); (R-MMU-9933947)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28315936;29374058;31219806;32848054;34887587;36852467;37507081;40997131", "class_list": "", "function": "Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CHH5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHW5-1", "uniprot_id": [ { "id": "BICL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHW5", "type": "external" } ], "mass": 57527.0, "length": 507, "protein_name": "BICD family-like cargo adapter 2", "gene_name": "Bicdl2", "organism": "Mouse", "refseq_name": "BICD family-like cargo adapter 2", "refseq_ac": [ { "id": "NP_722479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722479", "type": "external" } ], "gene_names_uniprotkb": "Bicdl2; Bicdr2; Ccdc64b", "gene_names_refseq": "BICDR-2; Bicdl2; Ccdc64b", "protein_names_uniprotkb": "BICD family-like cargo adapter 2; BICD-related protein 2; BICDR-2; Bicaudal D-related protein 2; Coiled-coil domain-containing protein 64B", "protein_names_refseq": "BICD family-like cargo adapter 2; BICD-related protein 2; bicaudal D-related protein 2; coiled-coil domain containing 64B; coiled-coil domain-containing protein 64B", "tax_id": 10090, "disease": "", "pathway": " (mmu:212733)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20360680;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CB50", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:0047496 vesicle transport along microtubule;GO:0055107 Golgi to secretory granule transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CHW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R015-1", "uniprot_id": [ { "id": "BL1S5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R015", "type": "external" } ], "mass": 21283.0, "length": 185, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 5", "gene_name": "Bloc1s5", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 5", "refseq_ac": [ { "id": "NP_620702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620702", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s5; Muted; Mu", "gene_names_refseq": "1810074A19Rik; Bloc1s5; Muted; mu", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 5; BLOC-1 subunit 5; Protein Muted homolog", "protein_names_refseq": "BLOC-1 subunit 5; biogenesis of lysosome-related organelles complex 1 subunit 5; biogenesis of organelles complex-1, subunit 5, muted; protein Muted homolog", "tax_id": 10090, "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:17828)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11912185;12019270;12576321;12923531;16760431;19546860;21998198;25673877;31219806", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The muted protein is involved in the selective export of CgA during the biogenesis of large dense-core vesicle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCP2;Q8CAC9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex;GO:1990742 microvesicle", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0031175 neuron projection development;GO:0016192 vesicle-mediated transport;GO:0008089 anterograde axonal transport;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1K4-1", "uniprot_id": [ { "id": "AT2L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1K4", "type": "external" } ], "mass": 51966.0, "length": 467, "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "Phykpl", "organism": "Mouse", "refseq_name": "5-phosphohydroxy-L-lysine phospho-lyase isoform 2", "refseq_ac": [ { "id": "NP_082674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082674", "type": "external" } ], "gene_names_uniprotkb": "Phykpl; Agxt2l2", "gene_names_refseq": "2900006B13Rik; Agxt2l2; Phykpl", "protein_names_uniprotkb": "5-phosphohydroxy-L-lysine phospho-lyase; 4.2.3.134; Alanine--glyoxylate aminotransferase 2-like 2", "protein_names_refseq": "5-phosphohydroxy-L-lysine phospho-lyase isoform 2; 5-phosphohydroxy-L-lysine phospho-lyase; alanine--glyoxylate aminotransferase 2-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72947); (R-MMU-1442490); (R-MMU-71064)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde., [UniProtKB, UniProtKB]; This gene overlaps in a tail-to-tail orientation the gene encoding heterogeneous nuclear ribonucleoprotein A/B. The terminal exon of this gene is interspersed with exons of heterogeneous nuclear ribonucleoprotein A/B. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUU9;Q8BG04", "ec_number_list": [ { "id": "4.2.3.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.134", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016829 lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WS4-1", "uniprot_id": [ { "id": "BHMT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WS4", "type": "external" } ], "mass": 39872.0, "length": 363, "protein_name": "S-methylmethionine--homocysteine S-methyltransferase BHMT2", "gene_name": "Bhmt2", "organism": "Mouse", "refseq_name": "S-methylmethionine--homocysteine S-methyltransferase BHMT2", "refseq_ac": [ { "id": "NP_075022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075022", "type": "external" } ], "gene_names_uniprotkb": "Bhmt2", "gene_names_refseq": "Bhmt2; D13Ucla2", "protein_names_uniprotkb": "S-methylmethionine--homocysteine S-methyltransferase BHMT2; 2.1.1.10; Betaine--homocysteine S-methyltransferase 2; SMM-hcy methyltransferase", "protein_names_refseq": "S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine--homocysteine S-methyltransferase 2", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:64918); (R-MMU-1614635)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11087663;17242355;18230605;19923254;20370499;30753104;34428180", "class_list": "", "function": "BHMT plays a central role in the homeostasis of cochlear methionine metabolism and Bhmt2 up-regulation could carry out a compensatory role in cochlear protection against noise injury in the absence of BHMT, [RefSeq, PubMed]; Betaine-homocysteine methyltransferase 2 (Bhmt2) was identified as a diet-dependent genetic factor that affected susceptibility to acetaminophen-induced liver toxicity in mice., [RefSeq, PubMed]; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor., [UniProtKB, PubMed]; The mouse liver extracts, containing the BHMT-2 homocysteine methyltransferase candidate for a similar activity, recognizes (S,S)-AdoMet but not (R,S)-AdoMet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1B1C9;Q8C1U2;Q9EQE8", "ec_number_list": [ { "id": "2.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.10", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0047150 betaine-homocysteine S-methyltransferase activity;GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity;GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0009086 methionine biosynthetic process;GO:0033477 S-methylmethionine metabolic process;GO:0046500 S-adenosylmethionine metabolic process;GO:0071267 L-methionine salvage", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NF1-1", "uniprot_id": [ { "id": "BCDO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NF1", "type": "external" } ], "mass": 60142.0, "length": 532, "protein_name": "Carotenoid-cleaving dioxygenase, mitochondrial", "gene_name": "Bco2", "organism": "Mouse", "refseq_name": "carotenoid-cleaving dioxygenase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_573480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573480", "type": "external" } ], "gene_names_uniprotkb": "Bco2; Bcdo2", "gene_names_refseq": "B-diox-II; Bcdo2; Bcmo2; Bco2; CMO2", "protein_names_uniprotkb": "Carotenoid-cleaving dioxygenase, mitochondrial; 1.13.11.-; 1.13.11.71; B-diox-II; Beta,beta-carotene 9',10'-oxygenase; Beta-carotene dioxygenase 2", "protein_names_refseq": "b,b-carotene-9',10'-dioxygenase; beta,beta-carotene 9',10'-oxygenase; beta-carotene 9', 10'-dioxygenase 2; beta-carotene dioxygenase 2; beta-diox-II; carotenoid-cleaving dioxygenase, mitochondrial isoform 1; carotenoid-cleaving dioxygenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:170752); (R-MMU-975634)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11278918;21106934;25428506;34161819;34418053", "class_list": "", "function": "Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids (PubMed:11278918, PubMed:21106934). Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond (PubMed:11278918, PubMed:21106934). Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules (PubMed:21106934)., [UniProtKB, PubMed, PubMed]; Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice., [RefSeq, PubMed]; We found that the third family member, beta,beta-carotene-9',10'-oxygenase (BCDO2), is a mitochondrial carotenoid-oxygenase with broad substrate specificity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.71", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0102076 beta,beta-carotene-9',10'-cleaving oxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0042573 retinoic acid metabolic process;GO:0042574 retinal metabolic process;GO:2000377 regulation of reactive oxygen species metabolic process;GO:0016116 carotenoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99NF1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CW73-1", "uniprot_id": [ { "id": "B3GA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CW73", "type": "external" } ], "mass": 38237.0, "length": 334, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1", "gene_name": "B3gat1", "organism": "Mouse", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_001297695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297695", "type": "external" } ], "gene_names_uniprotkb": "B3gat1", "gene_names_refseq": "0710007K08Rik; B3gat1; GlcAT-P; Glcatp; Hnk1", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; 2.4.1.135; Beta-1,3-glucuronyltransferase 1; GlcAT-P; GlcUAT-P; Glucuronosyltransferase P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase", "protein_names_refseq": "UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; glcUAT-P; glucuronosyltransferase P", "tax_id": 10090, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:76898); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11872162;12032138;25428506;30899004;36309510", "class_list": "glycogene;glycosyltransferase", "function": "A 207 bp fragment of the 5'-upstream region of mouse GlcAT-P gene acts as a strong promoter in PC-12 cells, which express the HNK-1 epitope., [RefSeq, PubMed]; Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; HNK-1 deficient mice exhibit impaired synaptic plasticity and spatial learning. (HNK-1, CD57), [RefSeq, PubMed]; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PIG8;Q8BXN8;Q8R531", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0071456 cellular response to hypoxia;GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 1.2, "record_id": "Q9CW73-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWF6-1", "uniprot_id": [ { "id": "BBS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWF6", "type": "external" } ], "mass": 79932.0, "length": 721, "protein_name": "BBSome complex member BBS2", "gene_name": "Bbs2", "organism": "Mouse", "refseq_name": "BBSome complex member BBS2", "refseq_ac": [ { "id": "NP_080392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080392", "type": "external" } ], "gene_names_uniprotkb": "Bbs2", "gene_names_refseq": "2410125H22Rik; Bbs2", "protein_names_uniprotkb": "BBSome complex member BBS2; Bardet-Biedl syndrome 2 protein homolog", "protein_names_refseq": "BBSome complex member BBS2; Bardet-Biedl syndrome 2 protein homolog", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 2 (Disease Ontology:DOID:0110124); retinitis pigmentosa 74 (Disease Ontology:DOID:0110401); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:67378); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11285252;15539463;18317593;22072986;32620959;36210013", "class_list": "", "function": "Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice., [RefSeq, PubMed]; Mice lacking Bbs2 gene expression have phenotypes associated with cilia dysfunction, including retinopathy, renal cysts, male infertility, and a deficit in olfaction, [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9585, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031514 motile cilium;GO:0043005 neuron projection;GO:0034451 centriolar satellite", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030534 adult behavior;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CWF6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXE2-1", "uniprot_id": [ { "id": "BCL7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXE2", "type": "external" } ], "mass": 22781.0, "length": 210, "protein_name": "B-cell CLL/lymphoma 7 protein family member A", "gene_name": "Bcl7a", "organism": "Mouse", "refseq_name": "B-cell CLL/lymphoma 7 protein family member A", "refseq_ac": [ { "id": "NP_084126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084126", "type": "external" } ], "gene_names_uniprotkb": "Bcl7a", "gene_names_refseq": "4432415N06Rik; Bcl7a", "protein_names_uniprotkb": "B-cell CLL/lymphoma 7 protein family member A", "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member A", "tax_id": 10090, "disease": "", "pathway": " (mmu:77045); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "36305367", "class_list": "", "function": "BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. Erratum:[EMBO J. 2024 Oct;43(19):4437-4438. doi: 10.1038/s44318-024-00157-7. PMID: 39223333], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C361;Q8C8M8;Q8VD15", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CXE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZP5-1", "uniprot_id": [ { "id": "BCS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZP5", "type": "external" } ], "mass": 47406.0, "length": 418, "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "Bcs1l", "organism": "Mouse", "refseq_name": "mitochondrial chaperone BCS1", "refseq_ac": [ { "id": "NP_001292581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292581", "type": "external" } ], "gene_names_uniprotkb": "Bcs1l", "gene_names_refseq": "9130022O19Rik; Bcs1l", "protein_names_uniprotkb": "Mitochondrial chaperone BCS1; 3.6.1.-; BCS1-like protein", "protein_names_refseq": "BCS1-like protein; mitochondrial chaperone BCS1", "tax_id": 10090, "disease": "Bjornstad syndrome (Disease Ontology:DOID:0050677); mitochondrial complex III deficiency nuclear type 1 (Disease Ontology:DOID:0080111); GRACILE syndrome (Disease Ontology:DOID:0111455)", "pathway": " (mmu:66821)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17049929;21274865;22829922;30084848;32979284;8599931", "class_list": "", "function": "Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III (PubMed:21274865). Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity)., [UniProtKB, UniProtKB, PubMed]; Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation., [RefSeq, PubMed]; Structural snapshots of the cellular folded protein translocation machinery Bcs1., [RefSeq, PubMed]; Studies in the yeast BCS1 ortholog indicate that the Bcs1 protein is anchored in the mitochondrial inner membrane, despite the absence of an N-terminal targeting sequence. Targeting occurs via charged amino acids near the transmembrane domain that act as an internal targeting signal., [RefSeq, PubMed]; The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency and is a viable mouse model for mitochondrial hepatopathy., [RefSeq, PubMed]; The predominant expression of BCS1L in the floor plate of the neural tube region, together with its presence in peripheral ganglia from E13 onwards, indicates a role for BCS1L in the development of neural structures., [RefSeq, PubMed]; The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008566 mitochondrial protein-transporting ATPase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007005 mitochondrion organization;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8Z6-1", "uniprot_id": [ { "id": "ATGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8Z6", "type": "external" } ], "mass": 25002.0, "length": 218, "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "organism": "Mouse", "refseq_name": "autophagy-related protein 101", "refseq_ac": [ { "id": "NP_080842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080842", "type": "external" } ], "gene_names_uniprotkb": "Atg101", "gene_names_refseq": "9430023L20Rik; Atg101", "protein_names_uniprotkb": "Autophagy-related protein 101", "protein_names_refseq": "autophagy-related protein 101", "tax_id": 10090, "disease": "colon cancer (Disease Ontology:DOID:219); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:68118); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010508 positive regulation of autophagy;GO:1903059 regulation of protein lipidation;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8Z6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIB3-1", "uniprot_id": [ { "id": "BIR1G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIB3", "type": "external" } ], "mass": 159664.0, "length": 1402, "protein_name": "Baculoviral IAP repeat-containing protein 1g", "gene_name": "Naip7", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 1g", "refseq_ac": [ { "id": "NP_067520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067520", "type": "external" } ], "gene_names_uniprotkb": "Naip7; Birc1g", "gene_names_refseq": "Birc1g; Naip-rs4B; Naip7", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1g; Neuronal apoptosis inhibitory protein 7", "protein_names_refseq": "baculoviral IAP repeat-containing protein 1g; neuronal apoptosis inhibitory protein 7", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (mmu:53880)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10958627;31219806", "class_list": "", "function": "Prevents motor-neuron apoptosis induced by a variety of signals., [UniProtKB]; This gene is found in 129X1 mice, but not in C57BL/6J mice, so it is not present in GRCm38.p4 (see PMID:12483212). [provided by RefSeq, Mar 2019]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0016045 detection of bacterium;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIB3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0L2-1", "uniprot_id": [ { "id": "ARTN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0L2", "type": "external" } ], "mass": 23726.0, "length": 224, "protein_name": "Artemin", "gene_name": "Artn", "organism": "Mouse", "refseq_name": "artemin isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001271120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271120", "type": "external" } ], "gene_names_uniprotkb": "Artn", "gene_names_refseq": "Artn; neublastin", "protein_names_uniprotkb": "Artemin", "protein_names_refseq": "artemin isoform 1 preproprotein", "tax_id": 10090, "disease": "acoustic neuroma (Disease Ontology:DOID:12689); pancreatic cancer (Disease Ontology:DOID:1793); peripheral nervous system disease (Disease Ontology:DOID:574)", "pathway": " (mmu:11876); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15204970;17322904;28270618;31358547;9883723", "class_list": "", "function": "Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor (PubMed:15204970). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (PubMed:17322904)., [UniProtKB, PubMed, PubMed, UniProtKB]; HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation., [RefSeq, PubMed]; Results demonstrate that the Artn gene is indeed regulated by the distal XRE-containing enhancer, and alloknesis in AhR-CA mice is provoked by the AhR-mediated direct induction of the Artn gene7 Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Mice lacking a functional copy of this gene exhibit ptosis and impaired development of the sympathetic nervous system. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXF4;Q3SXF5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0031175 neuron projection development;GO:0007422 peripheral nervous system development;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z0L2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2E5-1", "uniprot_id": [ { "id": "ATOH7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2E5", "type": "external" } ], "mass": 16569.0, "length": 149, "protein_name": "Transcription factor Atoh7", "gene_name": "Atoh7", "organism": "Mouse", "refseq_name": "transcription factor Atoh7 isoform 1", "refseq_ac": [ { "id": "NP_058560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058560", "type": "external" } ], "gene_names_uniprotkb": "Atoh7; Ath5", "gene_names_refseq": "Atoh7; Math5; bHLHa13", "protein_names_uniprotkb": "Transcription factor Atoh7; Atonal bHLH transcription factor 7; Helix-loop-helix protein mATH-5; Protein atonal homolog 7; mATH5", "protein_names_refseq": "helix-loop-helix protein mATH-5; protein atonal homolog 7; transcription factor Atoh7 isoform 1; transcription factor Atoh7", "tax_id": 10090, "disease": "persistent hyperplastic primary vitreous (Disease Ontology:DOID:0060282)", "pathway": " (mmu:53404)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11156601;11493566;11889557;12451142;17977745;26392540;33712461;9806930", "class_list": "", "function": "Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:33712461). Dimerization with TCF3 isoform E47 may be required in certain situations (By similarity). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (PubMed:33712461). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (PubMed:11156601, PubMed:11493566, PubMed:12451142, PubMed:33712461). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (PubMed:33712461). Required for retinal circadian rhythm photoentrainment (PubMed:12451142, PubMed:26392540). Plays a role in brainstem auditory signaling and binaural processing (PubMed:17977745)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0043204 perikaryon", "go_biological_process": "GO:0003407 neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z2E5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810M1-1", "uniprot_id": [ { "id": "CF299_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810M1", "type": "external" } ], "mass": 26938.0, "length": 233, "protein_name": "Cilia- and flagella-associated protein 299", "gene_name": "Cfap299", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 299 isoform 1", "refseq_ac": [ { "id": "NP_001019785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019785", "type": "external" } ], "gene_names_uniprotkb": "Cfap299; 1700007G11Rik", "gene_names_refseq": "1700007G11Rik; 4930428O21Rik; Cfap299", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 299", "protein_names_refseq": "cilia- and flagella-associated protein 299 isoform 1; uncharacterized protein C4orf22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75784)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30820741;35820727", "class_list": "", "function": "May be involved in spermatogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70460-1", "uniprot_id": [ { "id": "CCL19_MOUSE", "url": "https://www.uniprot.org/uniprot/O70460", "type": "external" } ], "mass": 11911.0, "length": 108, "protein_name": "C-C motif chemokine 19", "gene_name": "Ccl19", "organism": "Mouse", "refseq_name": "C-C motif chemokine 19 precursor", "refseq_ac": [ { "id": "NP_036018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036018", "type": "external" } ], "gene_names_uniprotkb": "Ccl19; Elc; Scya19", "gene_names_refseq": "CKb11; Ccl19; ELC; Gm2023; MIP3B; Scya19; exodus-3", "protein_names_uniprotkb": "C-C motif chemokine 19; EBI1 ligand chemokine; ELC; Epstein-Barr virus-induced molecule 1 ligand chemokine; Small-inducible cytokine A19", "protein_names_refseq": "C-C motif chemokine 19 precursor; C-C motif chemokine 19; EBI-1 ligand chemokine; EBI1 ligand chemokine; EBV-induced molecule 1 ligand chemokine; chemokine (C-C motif) ligand 19; chemokine CCL19; epstein-Barr virus-induced molecule 1 ligand chemokine; small-inducible cytokine A19", "tax_id": 10090, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (mmu:24047); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;26495903;33910988;37956733;9653094", "class_list": "", "function": "CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. Publication Status: Online-Only, [RefSeq, PubMed]; Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation., [RefSeq, PubMed]; Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0031735 CCR10 chemokine receptor binding;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding;GO:0031732 CCR7 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0046330 positive regulation of JNK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70460-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL96-1", "uniprot_id": [ { "id": "CATM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL96", "type": "external" } ], "mass": 37409.0, "length": 333, "protein_name": "Cathepsin M", "gene_name": "Ctsm", "organism": "Mouse", "refseq_name": "cathepsin M precursor", "refseq_ac": [ { "id": "NP_071721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071721", "type": "external" } ], "gene_names_uniprotkb": "Ctsm; Catm", "gene_names_refseq": "1600027J17Rik; Catm; Ctsm", "protein_names_uniprotkb": "Cathepsin M; 3.4.22.-", "protein_names_refseq": "Cat M; cathepsin M precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:64139)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10760593;11829493;12054558;15514457;16297992;21750661;34428180", "class_list": "", "function": "Placental cathepsin M is alternatively spliced and exclusively expressed in the spongiotrophoblast layer, [RefSeq, PubMed]; Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice., [RefSeq, PubMed]; Shows evolution in placental expression by gene duplidatoin, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z75;Q91ZF3;Q9CQB9", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0042393 histone binding;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005771 multivesicular body", "go_biological_process": "GO:0006508 proteolysis;GO:0046718 symbiont entry into host cell;GO:0016540 protein autoprocessing;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JL96-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70160-1", "uniprot_id": [ { "id": "CALC_MOUSE", "url": "https://www.uniprot.org/uniprot/P70160", "type": "external" } ], "mass": 15141.0, "length": 136, "protein_name": "Calcitonin", "gene_name": "Calca", "organism": "Mouse", "refseq_name": "calcitonin gene-related peptide 1 isoform Calca preproprotein", "refseq_ac": [ { "id": "NP_001292545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292545", "type": "external" } ], "gene_names_uniprotkb": "Calca; Calc", "gene_names_refseq": "CA; CGRP-1; CGRP1; Calc1; Calca; Calc; Cgrp; Ctn; Ct", "protein_names_uniprotkb": "Calcitonin", "protein_names_refseq": "alpha-type CGRP; calcitonin gene-related peptide 1 isoform Calca preproprotein; calcitonin gene-related peptide I", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pyelonephritis (Disease Ontology:DOID:11400); osteoporosis (Disease Ontology:DOID:11476); prediabetes syndrome (Disease Ontology:DOID:11716); ischemia (Disease Ontology:DOID:326); middle cerebral artery infarction (Disease Ontology:DOID:3525); migraine (Disease Ontology:DOID:6364); stomach disease (Disease Ontology:DOID:76); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12310); (R-MMU-418555); (R-MMU-419812)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11761712;18544925;21750661;8806650", "class_list": "", "function": "CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex., [UniProtKB, UniProtKB]; Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (By similarity)., [UniProtKB, UniProtKB]; This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1K5", "ec_number_list": [], "go_molecular_function": "GO:0031716 calcitonin receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure;GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70160-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDN1-1", "uniprot_id": [ { "id": "CC020_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDN1", "type": "external" } ], "mass": 104228.0, "length": 933, "protein_name": "Uncharacterized protein C3orf20 homolog", "gene_name": "4930590J08Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C3orf20 homolog", "refseq_ac": [ { "id": "NP_941070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941070", "type": "external" } ], "gene_names_uniprotkb": "4930590J08Rik", "gene_names_refseq": "4930590J08Rik; Gm1071", "protein_names_uniprotkb": "Uncharacterized protein C3orf20 homolog", "protein_names_refseq": "uncharacterized protein C3orf20 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381798)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36331537", "class_list": "", "function": "Impaired fertility in 4930590J08Rik mutant male mice is associated with defective sperm energy metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CDN1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LIT1-1", "uniprot_id": [ { "id": "CC194_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LIT1", "type": "external" } ], "mass": 25521.0, "length": 234, "protein_name": "Coiled-coil domain-containing protein 194", "gene_name": "Ccdc194", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 194 precursor", "refseq_ac": [ { "id": "NP_001357778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357778", "type": "external" } ], "gene_names_uniprotkb": "Ccdc194", "gene_names_refseq": "C430049E01Rik; Ccdc194", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 194", "protein_names_refseq": "coiled-coil domain-containing protein 194 precursor; coiled-coil domain-containing protein 194", "tax_id": 10090, "disease": "", "pathway": " (mmu:619297)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LIT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70354-1", "uniprot_id": [ { "id": "CAH11_MOUSE", "url": "https://www.uniprot.org/uniprot/O70354", "type": "external" } ], "mass": 36051.0, "length": 328, "protein_name": "Carbonic anhydrase-related protein 11", "gene_name": "Ca11; Car11", "organism": "Mouse", "refseq_name": "carbonic anhydrase-related protein 11 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033930", "type": "external" } ], "gene_names_uniprotkb": "Ca11; Car11; Car11; Carp2", "gene_names_refseq": "Ca11; Car11", "protein_names_uniprotkb": "Carbonic anhydrase-related protein 11; CA-RP II; CA-RP XI; CA-XI; CARP XI; CARP-2; Carbonic anhydrase-related protein 2", "protein_names_refseq": "CA-RP II; CA-RP XI; CA-XI; CARP XI; CARP-2; carbonic anhydrase-related protein 11 isoform 1 precursor; carbonic anhydrase-related protein 11; carbonic anhydrase-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12348)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12531530;21750661;30899004;9878252", "class_list": "", "function": "Does not have a catalytic activity., [UniProtKB]; Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 8818, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEA9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016836 hydro-lyase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70354-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8X2-1", "uniprot_id": [ { "id": "CC124_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8X2", "type": "external" } ], "mass": 25346.0, "length": 217, "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "Ccdc124", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 124", "refseq_ac": [ { "id": "NP_081240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081240", "type": "external" } ], "gene_names_uniprotkb": "Ccdc124", "gene_names_refseq": "1810023B24Rik; Ccdc124", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 124", "protein_names_refseq": "coiled-coil domain-containing protein 124", "tax_id": 10090, "disease": "", "pathway": " (mmu:234388)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage. Also required for proper progression of late cytokinetic stages., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2T0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61081-1", "uniprot_id": [ { "id": "CDC37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61081", "type": "external" } ], "mass": 44593.0, "length": 379, "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "Cdc37", "organism": "Mouse", "refseq_name": "hsp90 co-chaperone Cdc37 isoform 2", "refseq_ac": [ { "id": "NP_058022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058022", "type": "external" } ], "gene_names_uniprotkb": "Cdc37", "gene_names_refseq": "Cdc37; p50Cdc37; p50", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37", "protein_names_refseq": "cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; hsp90 co-chaperone Cdc37 isoform 2; hsp90 co-chaperone Cdc37", "tax_id": 10090, "disease": "", "pathway": " (mmu:12539); (R-MMU-1227986); (R-MMU-5675482); (R-MMU-8863795); (R-MMU-9013418); (R-MMU-9652282)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10409742;20173027;21750661;22872234;25153642;25428506;27251758;28284560;28528544;30039622;30084848;30779550;31219806;34428180;35820727;35984892;36210013;8666233", "class_list": "", "function": "Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 in hepatocellular carcinoma, reducing tumor growth., [RefSeq, PubMed]; Results showed that Cdc37 acts as a bridge to direct Hsp90 to the transcription factor viral P proteins of all lyssaviruses. Although Cdc37 can load P proteins onto Hsp90, with or without binding to Hsp90, the interaction between Cdc37 and Hsp90 appears to provide additional allosterical regulation of its chaperone activity. Notably, both phosphorylated and non-P Cdc37 could facilitate Hsp90-mediated protein maturation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGP0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032587 ruffle membrane;GO:0032991 protein-containing complex;GO:1990565 HSP90-CDC37 chaperone complex", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0050821 protein stabilization;GO:0060338 regulation of type I interferon-mediated signaling pathway;GO:0006457 protein folding;GO:0060334 regulation of type II interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE98-1", "uniprot_id": [ { "id": "CD276_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE98", "type": "external" } ], "mass": 34001.0, "length": 316, "protein_name": "CD276 antigen", "gene_name": "Cd276", "organism": "Mouse", "refseq_name": "CD276 antigen isoform 2 precursor", "refseq_ac": [ { "id": "NP_598744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598744", "type": "external" } ], "gene_names_uniprotkb": "Cd276; B7h3", "gene_names_refseq": "6030411F23Rik; B7-H3; B7RP-2; B7h3; Cd276", "protein_names_uniprotkb": "CD276 antigen; B7 homolog 3; B7-H3; Costimulatory molecule", "protein_names_refseq": "B7 homolog 3; CD276 antigen isoform 2 precursor; costimulatory molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:102657)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12055244;12906861;12925852;12939639;15294965;15682454;19349973;19656770;21750661;38226525;38396262;38561369", "class_list": "", "function": "B7-H3 serves as a negative regulator of T cell activation and function, [RefSeq, PubMed]; CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-beta/SMAD signaling., [RefSeq, PubMed]; CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells., [RefSeq, PubMed]; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Preferentially down-regulates t helper type 1-mediated immune responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0032689 negative regulation of type II interferon production;GO:0042110 T cell activation;GO:0042130 negative regulation of T cell proliferation;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8VE98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PG04-1", "uniprot_id": [ { "id": "CCD82_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PG04", "type": "external" } ], "mass": 61008.0, "length": 518, "protein_name": "Coiled-coil domain-containing protein 82", "gene_name": "Ccdc82", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 82", "refseq_ac": [ { "id": "NP_079810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079810", "type": "external" } ], "gene_names_uniprotkb": "Ccdc82", "gene_names_refseq": "2310043N13Rik; Ccdc82", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 82", "protein_names_refseq": "coiled-coil domain-containing protein 82", "tax_id": 10090, "disease": "", "pathway": " (mmu:66396)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V462", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PG04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE93-1", "uniprot_id": [ { "id": "CAHM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE93", "type": "external" } ], "mass": 35429.0, "length": 315, "protein_name": "Calcium homeostasis modulator protein 4", "gene_name": "Calhm4", "organism": "Mouse", "refseq_name": "calcium homeostasis modulator protein 4", "refseq_ac": [ { "id": "NP_001074634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074634", "type": "external" } ], "gene_names_uniprotkb": "Calhm4; Fam26d", "gene_names_refseq": "4732454E20Rik; Calhm4; Fam26d; Gm643", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 4; Protein FAM26D", "protein_names_refseq": "calcium homeostasis modulator protein 4; family with sequence similarity 26, member D; protein FAM26D", "tax_id": 10090, "disease": "", "pathway": " (mmu:270711)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May assemble to form gap junction channel-like structures involved in intercellular communication. Channel gating and ion conductance are likely regulated by membrane lipids rather than by membrane depolarization or extracellular calcium levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1904669 ATP export;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CE93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6P8-1", "uniprot_id": [ { "id": "CALL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6P8", "type": "external" } ], "mass": 16701.0, "length": 149, "protein_name": "Calmodulin-like protein 3", "gene_name": "Calml3", "organism": "Mouse", "refseq_name": "calmodulin-like protein 3", "refseq_ac": [ { "id": "NP_081692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081692", "type": "external" } ], "gene_names_uniprotkb": "Calml3", "gene_names_refseq": "2310068O22Rik; Calml3", "protein_names_uniprotkb": "Calmodulin-like protein 3", "protein_names_refseq": "calmodulin-like protein 3", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:70405)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26740625;39627609", "class_list": "", "function": "May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99K52", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043209 myelin sheath;GO:0150034 distal axon", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0005513 detection of calcium ion;GO:0051649 establishment of localization in cell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D6P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AGB2-1", "uniprot_id": [ { "id": "CA087_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AGB2", "type": "external" } ], "mass": 62440.0, "length": 545, "protein_name": "Uncharacterized protein C1orf87 homolog", "gene_name": "Gm12695", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf87 homolog", "refseq_ac": [ { "id": "NP_001074753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074753", "type": "external" } ], "gene_names_uniprotkb": "Gm12695", "gene_names_refseq": "Gm12695", "protein_names_uniprotkb": "Uncharacterized protein C1orf87 homolog", "protein_names_refseq": "uncharacterized protein C1orf87 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:620779)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AGB2-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z238-1", "uniprot_id": [ { "id": "CCNE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z238", "type": "external" } ], "mass": 46669.0, "length": 404, "protein_name": "G1/S-specific cyclin-E2", "gene_name": "Ccne2", "organism": "Mouse", "refseq_name": "G1/S-specific cyclin-E2 isoform 1", "refseq_ac": [ { "id": "NP_001032211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032211", "type": "external" } ], "gene_names_uniprotkb": "Ccne2", "gene_names_refseq": "Ccne2", "protein_names_uniprotkb": "G1/S-specific cyclin-E2", "protein_names_refseq": "G1/S-specific cyclin-E2 isoform 1; G1/S-specific cyclin-E2", "tax_id": 10090, "disease": "castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:12448); (R-MMU-1538133); (R-MMU-187577); (R-MMU-2559586); (R-MMU-6804116); (R-MMU-69017); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69563)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "21183079;21750661;25428506;25605945;30084848;30779550;34428180;37828378;9840927;9858585", "class_list": "", "function": "Essential for the control of the cell cycle at the late G1 and early S phase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWU5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0097134 cyclin E1-CDK2 complex;GO:0097135 cyclin E2-CDK2 complex", "go_biological_process": "GO:0051301 cell division;GO:0000723 telomere maintenance;GO:0032880 regulation of protein localization;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z238-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YZV8-1", "uniprot_id": [ { "id": "CCDC8_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YZV8", "type": "external" } ], "mass": 73938.0, "length": 685, "protein_name": "Coiled-coil domain-containing protein 8 homolog", "gene_name": "Ccdc8", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 8 homolog", "refseq_ac": [ { "id": "NP_001095005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095005", "type": "external" } ], "gene_names_uniprotkb": "Ccdc8", "gene_names_refseq": "Ccdc8", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 8 homolog", "protein_names_refseq": "coiled-coil domain-containing protein 8 homolog", "tax_id": 10090, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (mmu:434130)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YZV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEC4-1", "uniprot_id": [ { "id": "CAHM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEC4", "type": "external" } ], "mass": 35823.0, "length": 323, "protein_name": "Calcium homeostasis modulator protein 2", "gene_name": "Calhm2", "organism": "Mouse", "refseq_name": "calcium homeostasis modulator protein 2", "refseq_ac": [ { "id": "NP_598507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598507", "type": "external" } ], "gene_names_uniprotkb": "Calhm2; Fam26b", "gene_names_refseq": "2810048G17Rik; Calhm2; Fam26b", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 2; Protein FAM26B", "protein_names_refseq": "calcium homeostasis modulator 2; calcium homeostasis modulator protein 2", "tax_id": 10090, "disease": "dementia (Disease Ontology:DOID:1307); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:72691)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;26740625;29180673;34428180;34433553;37064868;37493186;37926398;38280307", "class_list": "", "function": "CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer's disease risk. Erratum:[Alzheimers Dement. 2024 Aug;20(8):5809. doi: 10.1002/alz.13822. PMID: 38923157], [RefSeq, PubMed]; Calcium homeostasis modulator 2 (Calhm2) as slowly activating membrane current channel in mouse B cells., [RefSeq, PubMed]; Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia. Publication Status: Online-Only, [RefSeq, PubMed]; Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown., [UniProtKB, PubMed, UniProtKB, PubMed]; Upregulation of Calhm2 in the anterior cingulate cortex contributes to the maintenance of bilateral mechanical allodynia and comorbid anxiety symptoms in inflammatory pain conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDQ7;Q8BT85;Q8C246", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0048167 regulation of synaptic plasticity;GO:0070509 calcium ion import;GO:1903978 regulation of microglial cell activation;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VEC4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVT6-1", "uniprot_id": [ { "id": "CAH14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVT6", "type": "external" } ], "mass": 37505.0, "length": 337, "protein_name": "Carbonic anhydrase 14", "gene_name": "Ca14; Car14", "organism": "Mouse", "refseq_name": "carbonic anhydrase 14 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035927", "type": "external" } ], "gene_names_uniprotkb": "Ca14; Car14; Car14; Catm", "gene_names_refseq": "CA-XIV; Ca14; Car14", "protein_names_uniprotkb": "Carbonic anhydrase 14; 4.2.1.1; CA-XIV; Carbonate dehydratase XIV; Carbonic anhydrase XIV", "protein_names_refseq": "CA XIV; carbonate dehydratase XIV; carbonic anhydrase 14 isoform 1 precursor; carbonic anhydrase XIV", "tax_id": 10090, "disease": "", "pathway": " (mmu:23831); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10336468;12033992;14660577;16260723;21750661;30899004;34428180;35119514;35820727;36302497", "class_list": "", "function": "Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner., [RefSeq, PubMed]; Carbonic anhydrase XIV has a role in selective inhibition of membrane-associated isozymes, [RefSeq, PubMed]; Loss of luminal carbonic anhydrase XIV results in decreased biliary bicarbonate output, liver fibrosis, and cholangiocyte proliferation in mice., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, PubMed]; Studies on hippocampal slices on these KO mice showed that either CA can mediate buffering after synaptic transmission in hippocampal slices in the absence of the other, but that eliminating both is as effective in blocking the buffering seen in WT mice, [RefSeq, PubMed]; The presence of CA XIV in the hepatocyte plasma membrane places it at a strategic site to control pH regulation and ion transport between the hepatocytes, sinusoids and bile canaliculi. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WVT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5T1-1", "uniprot_id": [ { "id": "CCD78_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5T1", "type": "external" } ], "mass": 49472.0, "length": 437, "protein_name": "Coiled-coil domain-containing protein 78", "gene_name": "Ccdc78", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 78", "refseq_ac": [ { "id": "NP_001159401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159401", "type": "external" } ], "gene_names_uniprotkb": "Ccdc78", "gene_names_refseq": "Ccdc78; Gm938; Gm950", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 78", "protein_names_refseq": "coiled-coil domain-containing protein 78", "tax_id": 10090, "disease": "centronuclear myopathy 4 (Disease Ontology:DOID:0111224)", "pathway": " (mmu:381077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34887587;35820727", "class_list": "", "function": "Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0042383 sarcolemma;GO:0005814 centriole;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0030030 cell projection organization;GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z5T1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5W4-1", "uniprot_id": [ { "id": "CCD81_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5W4", "type": "external" } ], "mass": 75826.0, "length": 654, "protein_name": "Coiled-coil domain-containing protein 81", "gene_name": "Ccdc81", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 81", "refseq_ac": [ { "id": "NP_001156451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156451", "type": "external" } ], "gene_names_uniprotkb": "Ccdc81", "gene_names_refseq": "4921513D09Rik; Ccdc81", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 81", "protein_names_refseq": "coiled-coil domain-containing protein 81", "tax_id": 10090, "disease": "", "pathway": " (mmu:70884)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29237092", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L0U4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D5W4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDN4-1", "uniprot_id": [ { "id": "CCD92_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDN4", "type": "external" } ], "mass": 35207.0, "length": 314, "protein_name": "Coiled-coil domain-containing protein 92", "gene_name": "Ccdc92", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 92", "refseq_ac": [ { "id": "NP_659068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659068", "type": "external" } ], "gene_names_uniprotkb": "Ccdc92; D5Bwg0834e", "gene_names_refseq": "Ccdc92; D5Bwg0834e", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 92", "protein_names_refseq": "coiled-coil domain-containing protein 92", "tax_id": 10090, "disease": "", "pathway": " (mmu:215707)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Interferon-stimulated protein that plays a role in innate immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:0044546 NLRP3 inflammasome complex assembly;GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0006954 inflammatory response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDN4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11942-1", "uniprot_id": [ { "id": "CD3G_MOUSE", "url": "https://www.uniprot.org/uniprot/P11942", "type": "external" } ], "mass": 20234.0, "length": 182, "protein_name": "T-cell surface glycoprotein CD3 gamma chain", "gene_name": "Cd3g", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD3 gamma chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_033980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033980", "type": "external" } ], "gene_names_uniprotkb": "Cd3g", "gene_names_refseq": "Cd3g; Ctg-3; Ctg3; T3g", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain", "protein_names_refseq": "T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain isoform 1 precursor; T-cell surface glycoprotein CD3 gamma chain", "tax_id": 10090, "disease": "immunodeficiency 17 (Disease Ontology:DOID:0111973)", "pathway": " (mmu:12502); (R-MMU-198933); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-389948); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "21750661;25605945;25920998;2827170;2952720;30084848;3655657;38255822;9524111", "class_list": "", "function": "Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G (PubMed:25920998)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0015031 protein transport;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q0B3-1", "uniprot_id": [ { "id": "CC080_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q0B3", "type": "external" } ], "mass": 25757.0, "length": 247, "protein_name": "Uncharacterized membrane protein C3orf80 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized membrane protein C3orf80 homolog precursor", "refseq_ac": [ { "id": "NP_001161468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161468", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1110032F04Rik", "protein_names_uniprotkb": "Uncharacterized membrane protein C3orf80 homolog", "protein_names_refseq": "uncharacterized membrane protein C3orf80 homolog precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68725)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4H3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q0B3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDI7-1", "uniprot_id": [ { "id": "CC150_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDI7", "type": "external" } ], "mass": 128502.0, "length": 1110, "protein_name": "Coiled-coil domain-containing protein 150", "gene_name": "Ccdc150", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 150", "refseq_ac": [ { "id": "NP_084301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084301", "type": "external" } ], "gene_names_uniprotkb": "Ccdc150", "gene_names_refseq": "4930511H11Rik; Ccdc150", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 150", "protein_names_refseq": "coiled-coil domain-containing protein 150", "tax_id": 10090, "disease": "", "pathway": " (mmu:78016)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMC0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CDI7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI85-1", "uniprot_id": [ { "id": "CAH12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI85", "type": "external" } ], "mass": 39695.0, "length": 354, "protein_name": "Carbonic anhydrase 12", "gene_name": "Ca12; Car12", "organism": "Mouse", "refseq_name": "carbonic anhydrase 12 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001293077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293077", "type": "external" } ], "gene_names_uniprotkb": "Ca12; Car12; Car12", "gene_names_refseq": "2310047E01Rik; CA-XII; Ca12; Car12", "protein_names_uniprotkb": "Carbonic anhydrase 12; 4.2.1.1; CA-XII; Carbonate dehydratase XII; Carbonic anhydrase XII", "protein_names_refseq": "CA XII; carbonate dehydratase XII; carbonic anhydrase 12 isoform 2 precursor; carbonic anhydrase XII", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); isolated hyperchlorhidrosis (Disease Ontology:DOID:0111371); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); fibrolamellar carcinoma (Disease Ontology:DOID:5015); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:76459); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14983512;16719910;21750661;26486891;28011936;30084848;31219806;34428180", "class_list": "", "function": "CA12 may regulate ion and pH homeostasis within the developing embryo. Publication Status: Online-Only, [RefSeq, PubMed]; High expression in the kidney and colon suggests a role for carbonic anhydrase XII in the maintenance of body ion and pH homeostasis in the mouse., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKG6", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0044849 estrous cycle;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CI85-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000100010000.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70407-1", "uniprot_id": [ { "id": "CADH9_MOUSE", "url": "https://www.uniprot.org/uniprot/P70407", "type": "external" } ], "mass": 88301.0, "length": 786, "protein_name": "Cadherin-9", "gene_name": "Cdh9", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdh9", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-9; T1-cadherin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:12565); (R-MMU-418990)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31599954;8620560;8879495", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0098641 cadherin binding involved in cell-cell adhesion", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005912 adherens junction;GO:0030424 axon;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007416 synapse assembly;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P70407-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERQ8-1", "uniprot_id": [ { "id": "CAH7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERQ8", "type": "external" } ], "mass": 29915.0, "length": 264, "protein_name": "Carbonic anhydrase 7", "gene_name": "Ca7; Car7", "organism": "Mouse", "refseq_name": "carbonic anhydrase 7 isoform b", "refseq_ac": [ { "id": "NP_001288093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288093", "type": "external" } ], "gene_names_uniprotkb": "Ca7; Car7; Car7", "gene_names_refseq": "Ca7; Car7", "protein_names_uniprotkb": "Carbonic anhydrase 7; 4.2.1.1; CA-VII; Carbonate dehydratase VII; Carbonic anhydrase VII", "protein_names_refseq": "CA-VII; carbonate dehydratase VII; carbonic anhydrase 7 isoform b; carbonic anhydrase VII", "tax_id": 10090, "disease": "", "pathway": " (mmu:12354); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;23881097;9692974", "class_list": "", "function": "Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811X4", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88324-1", "uniprot_id": [ { "id": "CD83_MOUSE", "url": "https://www.uniprot.org/uniprot/O88324", "type": "external" } ], "mass": 21313.0, "length": 196, "protein_name": "CD83 antigen", "gene_name": "Cd83", "organism": "Mouse", "refseq_name": "CD83 antigen isoform 1 precursor", "refseq_ac": [ { "id": "NP_033986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033986", "type": "external" } ], "gene_names_uniprotkb": "Cd83", "gene_names_refseq": "Cd83", "protein_names_uniprotkb": "CD83 antigen; mCD83", "protein_names_refseq": "CD83 antigen isoform 1 precursor; mCD83", "tax_id": 10090, "disease": "", "pathway": " (mmu:12522)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11884422;11955430;12072358;12687354;26495903;27503069;27503071;31527313;36003376;9799334", "class_list": "glycogene", "function": "CD83 expression influences CD4+ T cell development in the thymus., [RefSeq, PubMed]; Murine CD83 is expressed mainly on mature dendritic cells and on activated T cells, [RefSeq, PubMed]; Soluble CD83-Ig fusion protein is immunosuppressive, costimulatory when coimmobilized with anti-CD3, and by interacting with its ligand(s) is involved in regulation of immune response to tumor., [RefSeq, PubMed]; The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; The soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83. Review article, [RefSeq, PubMed]; Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8 (PubMed:27503071, PubMed:27503069). Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII (By similarity). In addition, acts as an important modulator of protective responses against acute infections (PubMed:31527313)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 9868, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032743 positive regulation of interleukin-2 production;GO:0032733 positive regulation of interleukin-10 production;GO:0032713 negative regulation of interleukin-4 production;GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O88324-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06332-1", "uniprot_id": [ { "id": "CD4_MOUSE", "url": "https://www.uniprot.org/uniprot/P06332", "type": "external" } ], "mass": 51297.0, "length": 457, "protein_name": "T-cell surface glycoprotein CD4", "gene_name": "Cd4", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD4 precursor", "refseq_ac": [ { "id": "NP_038516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038516", "type": "external" } ], "gene_names_uniprotkb": "Cd4", "gene_names_refseq": "Cd4; L3T4; Ly-4", "protein_names_uniprotkb": "T-cell surface glycoprotein CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3", "protein_names_refseq": "T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 precursor; T-cell surface glycoprotein CD4", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); immunodeficiency 79 (Disease Ontology:DOID:0112277); sialadenitis (Disease Ontology:DOID:10303); severe acute respiratory syndrome (Disease Ontology:DOID:2945); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); amphetamine abuse (Disease Ontology:DOID:670); septic arthritis (Disease Ontology:DOID:813); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12504); (R-MMU-1462054); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-389948); (R-MMU-449836); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "10706685;16709847;1832488;2512251;26495903;2784195;2823269;3027575;3082751;3086886;3094146;32152506;3262426;3326818;9445485", "class_list": "", "function": "Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0015026 coreceptor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P06332-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08920-1", "uniprot_id": [ { "id": "CD2_MOUSE", "url": "https://www.uniprot.org/uniprot/P08920", "type": "external" } ], "mass": 38415.0, "length": 344, "protein_name": "T-cell surface antigen CD2", "gene_name": "Cd2", "organism": "Mouse", "refseq_name": "T-cell surface antigen CD2 precursor", "refseq_ac": [ { "id": "NP_038514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038514", "type": "external" } ], "gene_names_uniprotkb": "Cd2; Ly-37", "gene_names_refseq": "Cd2; LFA-2; Ly-37; Ly37", "protein_names_uniprotkb": "T-cell surface antigen CD2; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte antigen 37; T-cell surface antigen T11/Leu-5", "protein_names_refseq": "LFA-3 receptor; T-cell surface antigen CD2 precursor; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; lymphocyte antigen 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:12481)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12530983;2440689;26495903;28011936;2820751;2894031;30084848;32213736;32477356;3257775;34428180;34552089;9741631", "class_list": "", "function": "CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract. Publication Status: Online-Only, [RefSeq, PubMed]; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function., [UniProtKB]; CD2 is a surface marker for mouse and rat spermatogonial stem cells., [RefSeq, PubMed]; Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q61394", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006955 immune response;GO:0098609 cell-cell adhesion;GO:0032760 positive regulation of tumor necrosis factor production;GO:0032729 positive regulation of type II interferon production;GO:0032757 positive regulation of interleukin-8 production", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P08920-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP27-1", "uniprot_id": [ { "id": "CALM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DP27", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-2", "gene_name": "Calm2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Calm2; Cam2; CamC", "gene_names_refseq": "", "protein_names_uniprotkb": "Calmodulin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); long QT syndrome 15 (Disease Ontology:DOID:0110656); major depressive disorder (Disease Ontology:DOID:1470); cancer (Disease Ontology:DOID:162); substance abuse (Disease Ontology:DOID:302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12313); (mmu:12314); (mmu:12315)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16075062;16670015;18034455;18650434;21183079;23806337;24569478;25380116;2551780;34428180;39627609;7828884", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62204;P70667;P99014;Q3TEH7;Q3THK5;Q3U6Z5;Q3U7C7;Q498A3;Q61379;Q61380;Q8BNC9;Q91VQ9;Q9D6G4", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P0DP27-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP28-1", "uniprot_id": [ { "id": "CALM3_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DP28", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-3", "gene_name": "Calm3", "organism": "Mouse", "refseq_name": "calmodulin-2 isoform 1", "refseq_ac": [ { "id": "NP_031615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031615", "type": "external" } ], "gene_names_uniprotkb": "Calm3; Cam3; Camc", "gene_names_refseq": "1500001E21Rik; Calm2; Cam2; CamC", "protein_names_uniprotkb": "Calmodulin-3", "protein_names_refseq": "caM; calmodulin-2 isoform 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); long QT syndrome 16 (Disease Ontology:DOID:0070533); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12313); (mmu:12314); (mmu:12315)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "18034455;18650434;21183079;23806337;24569478;25380116;3384819;39927985", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62204;P70667;P99014;Q3TEH7;Q3THK5;Q3U6Z5;Q3U7C7;Q498A3;Q61379;Q61380;Q8BNC9;Q91VQ9;Q9D6G4", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0DP28-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10287-1", "uniprot_id": [ { "id": "CADH3_MOUSE", "url": "https://www.uniprot.org/uniprot/P10287", "type": "external" } ], "mass": 90612.0, "length": 822, "protein_name": "Cadherin-3", "gene_name": "Cdh3", "organism": "Mouse", "refseq_name": "cadherin-3 isoform a preproprotein", "refseq_ac": [ { "id": "NP_001032898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032898", "type": "external" } ], "gene_names_uniprotkb": "Cdh3; Cdhp", "gene_names_refseq": "Cadp; Cdh3; Cdhp; P-cadherin; Pcad", "protein_names_uniprotkb": "Cadherin-3; P-cadherin; Placental cadherin", "protein_names_refseq": "RPE-specific cadherin; cadherin-3 isoform a preproprotein; placental cadherin", "tax_id": 10090, "disease": "congenital hypotrichosis with juvenile macular dystrophy (Disease Ontology:DOID:0110711); ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (Disease Ontology:DOID:0111649)", "pathway": " (mmu:12560); (R-MMU-418990)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1886768;21540332;3428270;35820727;8515462;8879495", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61465;Q8BSL6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030054 cell junction;GO:0016342 catenin complex", "go_biological_process": "GO:0048820 hair follicle maturation;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration;GO:0031424 keratinization;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10287-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28293-1", "uniprot_id": [ { "id": "CATG_MOUSE", "url": "https://www.uniprot.org/uniprot/P28293", "type": "external" } ], "mass": 29096.0, "length": 261, "protein_name": "Cathepsin G", "gene_name": "Ctsg", "organism": "Mouse", "refseq_name": "cathepsin G preproprotein", "refseq_ac": [ { "id": "NP_031826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031826", "type": "external" } ], "gene_names_uniprotkb": "Ctsg", "gene_names_refseq": "CatG; Ctsg; VSP", "protein_names_uniprotkb": "Cathepsin G; 3.4.21.20; VSP; Vimentin-specific protease", "protein_names_refseq": "cathepsin G preproprotein; vimentin-specific protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:13035); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-2022377); (R-MMU-448706); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "1577012;29187734;31727956;8453108;9211743", "class_list": "", "function": "Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease with trypsin- and chymotrypsin-like specificity. Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity. Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu. Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site. Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor. Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells. Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity. Cleaves complement C3 (By similarity). Cleaves vimentin (PubMed:1577012). Cleaves thrombin receptor F2R/PAR1. Cleaves the synovial mucin-type protein PRG4/lubricin. Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes. Cleaves IL33 into mature forms which have greater activity than the unprocessed form. Cleaves coagulation factor F8 to produce a partially activated form. Also cleaves and activates coagulation factor F10. Cleaves leukocyte cell surface protein SPN/CD43 to release its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol. Cleaves MBP in B cell lysosomes at '221-Phe-|-Lys-222', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells. Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis. Has antibacterial activity against the Gram-negative bacteria N.gonorrhoeae and P.aeruginosa. Likely to act against N.gonorrhoeae by interacting with N.gonorrhoeae penA/PBP2. Exhibits potent antimicrobial activity against the Gram-positive bacterium L.monocytogenes. Has antibacterial activity against the Gram-positive bacterium S.aureus and degrades S.aureus biofilms, allowing polymorphonuclear leukocytes to penetrate the biofilm and phagocytose bacteria. Has antibacterial activity against M.tuberculosis (By similarity). Induces platelet aggregation which is strongly potentiated in the presence of ELANE (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0008233 peptidase activity;GO:0048018 receptor ligand activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0019731 antibacterial humoral response;GO:0032496 response to lipopolysaccharide;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28293-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28651-1", "uniprot_id": [ { "id": "CAH8_MOUSE", "url": "https://www.uniprot.org/uniprot/P28651", "type": "external" } ], "mass": 33081.0, "length": 291, "protein_name": "Carbonic anhydrase-related protein", "gene_name": "Ca8", "organism": "Mouse", "refseq_name": "carbonic anhydrase-related protein", "refseq_ac": [ { "id": "NP_031618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031618", "type": "external" } ], "gene_names_uniprotkb": "Ca8; Cals1; Cals; Car8; Carp", "gene_names_refseq": "Ca8; Cals1; Cals; Car8; Carp; wdl", "protein_names_uniprotkb": "Carbonic anhydrase-related protein; CA-VIII; CARP; Carbonic anhydrase VIII", "protein_names_refseq": "CA-RP VIII; CA-VIII; carbonic anhydrase VIII; carbonic anhydrase-like sequence 1; carbonic anhydrase-related protein", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); autosomal recessive spinocerebellar ataxia 34 (Disease Ontology:DOID:0070558)", "pathway": " (mmu:12319)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10671200;12531530;2121526;8977131", "class_list": "", "function": "Does not have a carbonic anhydrase catalytic activity., [UniProtKB]; Results describe the tissue distribution of carbonic anhydrase-related proteins VIII, X, and XI and their developmental expression in the murine embryonic brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF58;Q91XF6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28651-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33146-1", "uniprot_id": [ { "id": "CAD15_MOUSE", "url": "https://www.uniprot.org/uniprot/P33146", "type": "external" } ], "mass": 85644.0, "length": 784, "protein_name": "Cadherin-15", "gene_name": "Cdh15", "organism": "Mouse", "refseq_name": "cadherin-15 preproprotein", "refseq_ac": [ { "id": "NP_031688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031688", "type": "external" } ], "gene_names_uniprotkb": "Cdh15; Cdh14", "gene_names_refseq": "Cdh14; Cdh15; Mcad", "protein_names_uniprotkb": "Cadherin-15; Cadherin-14; M-cadherin; Muscle cadherin", "protein_names_refseq": "M-cadherin; cadherin-14; cadherin-15 preproprotein; muscle cadherin", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 3 (Disease Ontology:DOID:0070033)", "pathway": " (mmu:12555); (R-MMU-418990); (R-MMU-525793)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10610704;1840697;19656770;30899004;33527978", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation., [UniProtKB]; The cooperation of cis-elements during M-cadherin promoter activation., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Based on the expression of this gene in skeletal muscle, satellite cells and cerebellum, it was postulated that the encoded protein may be important for muscle development and regeneration. Mice lacking the encoded protein appear normal and display no discernible defects in skeletal musculature. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RXU1;Q9QYZ7", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0031594 neuromuscular junction;GO:0005901 caveola", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33146-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47753-1", "uniprot_id": [ { "id": "CAZA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P47753", "type": "external" } ], "mass": 32940.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-1", "gene_name": "Capza1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capza1; Cappa1", "gene_names_refseq": "", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-1; CapZ alpha-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-879415)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "18299400;20173027;21750661;21952136;23806337;25428506;25428507;25605945;26495903;26740625;28011936;30084848;31219806;34428180;35820727;35984892;37828378;9331217", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YN7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0008290 F-actin capping protein complex", "go_biological_process": "GO:0034329 cell junction assembly;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47753-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49070-1", "uniprot_id": [ { "id": "CAMLG_MOUSE", "url": "https://www.uniprot.org/uniprot/P49070", "type": "external" } ], "mass": 32542.0, "length": 294, "protein_name": "Guided entry of tail-anchored proteins factor CAMLG", "gene_name": "Camlg", "organism": "Mouse", "refseq_name": "guided entry of tail-anchored proteins factor CAMLG", "refseq_ac": [ { "id": "NP_031622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031622", "type": "external" } ], "gene_names_uniprotkb": "Camlg; Caml; Get2", "gene_names_refseq": "Camlg; Caml", "protein_names_uniprotkb": "Guided entry of tail-anchored proteins factor CAMLG; Calcium signal-modulating cyclophilin ligand", "protein_names_refseq": "calcium signal-modulating cyclophilin ligand; guided entry of tail-anchored proteins factor CAMLG", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIz (Disease Ontology:DOID:0051053); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (mmu:12328)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22351938;25428506;26561552;27837104;32910895;7590290", "class_list": "", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (By similarity). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required for the stability of GET1 (By similarity). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity). Essential for the survival of peripheral follicular B cells (PubMed:22351938)., [UniProtKB, UniProtKB, PubMed]; Supports T cell survival and cell division downstream of T cell activation, [RefSeq, PubMed]; This study identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99JU5", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0016192 vesicle-mediated transport;GO:0031397 negative regulation of protein ubiquitination;GO:0001782 B cell homeostasis;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49070-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51675-1", "uniprot_id": [ { "id": "CCR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P51675", "type": "external" } ], "mass": 40895.0, "length": 355, "protein_name": "C-C chemokine receptor type 1", "gene_name": "Ccr1", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 1", "refseq_ac": [ { "id": "NP_034042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034042", "type": "external" } ], "gene_names_uniprotkb": "Ccr1; Cmkbr1", "gene_names_refseq": "Ccr1; Cmkbr1; Mip-1a-R", "protein_names_uniprotkb": "C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; MIP-1alpha-R; Macrophage inflammatory protein 1-alpha receptor; RANTES-R", "protein_names_refseq": "C-C CKR-1; C-C chemokine receptor type 1; CC-CKR-1; CCR-1; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES-R; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; macrophage inflammatory protein 1-alpha receptor", "tax_id": 10090, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); allergic contact dermatitis (Disease Ontology:DOID:3042); coronary artery disease (Disease Ontology:DOID:3393); liver cirrhosis (Disease Ontology:DOID:5082); rheumatoid arthritis (Disease Ontology:DOID:7148); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (mmu:12768); (R-MMU-418594)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15831559;31898284;38070823;38750114;7542241;7594543;9166425", "class_list": "", "function": "Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis., [RefSeq, PubMed]; Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:9166425). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (By similarity). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (PubMed:15831559). Also mediates monocyte migration upon CXCL4 binding (By similarity). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (PubMed:31898284)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWR7;Q91VP9", "ec_number_list": [], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0071791 chemokine (C-C motif) ligand 5 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51675-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51676-1", "uniprot_id": [ { "id": "CC1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/P51676", "type": "external" } ], "mass": 40849.0, "length": 356, "protein_name": "C-C chemokine receptor 1-like protein 1", "gene_name": "Ccr1l1", "organism": "Mouse", "refseq_name": "C-C chemokine receptor 1-like protein 1", "refseq_ac": [ { "id": "NP_031744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031744", "type": "external" } ], "gene_names_uniprotkb": "Ccr1l1; Cmkbr1l1", "gene_names_refseq": "Ccr1l1; Cmkbr1l1", "protein_names_uniprotkb": "C-C chemokine receptor 1-like protein 1; Macrophage inflammatory protein 1 alpha receptor-like 1", "protein_names_refseq": "C-C chemokine receptor 1-like protein 1; MIP-1 alphaRL1; chemokine (C-C motif) receptor 1-like 1; chemokine (C-C) receptor 1-like 1; macrophage inflammatory protein-1 alpha receptor-like 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); allergic contact dermatitis (Disease Ontology:DOID:3042); coronary artery disease (Disease Ontology:DOID:3393); liver cirrhosis (Disease Ontology:DOID:5082); rheumatoid arthritis (Disease Ontology:DOID:7148); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (mmu:12770)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33548230;7542241", "class_list": "", "function": "Probable receptor for a C-C type chemokine., [UniProtKB]; Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JP35", "ec_number_list": [], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0071791 chemokine (C-C motif) ligand 5 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51676-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51678-1", "uniprot_id": [ { "id": "CCR3_MOUSE", "url": "https://www.uniprot.org/uniprot/P51678", "type": "external" } ], "mass": 41783.0, "length": 359, "protein_name": "Probable C-C chemokine receptor type 3", "gene_name": "Ccr3", "organism": "Mouse", "refseq_name": "probable C-C chemokine receptor type 3", "refseq_ac": [ { "id": "NP_034044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034044", "type": "external" } ], "gene_names_uniprotkb": "Ccr3; Cmkbr1l2; Cmkbr3", "gene_names_refseq": "CC-CKR3; CKR3; Ccr3; Cmkbr1l2; Cmkbr3", "protein_names_uniprotkb": "Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; MIP-1 alpha RL2; Macrophage inflammatory protein 1-alpha receptor-like 2", "protein_names_refseq": "C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; MIP-1 alpha RL2; MIP-1 alphaRL2; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; macrophage inflammatory protein 1-alpha receptor-like 2; probable C-C chemokine receptor type 3", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); hepatitis B (Disease Ontology:DOID:2043); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12771); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11830666;35780587;36934154;37611377;38687790;7542241;7594543", "class_list": "", "function": "CCR3 gene knockout inhibits proliferation, differentiation, and migration of eosinophils in allergic rhinitis model mice., [RefSeq, PubMed]; CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain. Publication Status: Online-Only, [RefSeq, PubMed]; CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV., [RefSeq, PubMed]; G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. May also act as a possible functional receptor for NARS1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3M7", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51678-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51945-1", "uniprot_id": [ { "id": "CCNG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P51945", "type": "external" } ], "mass": 33903.0, "length": 294, "protein_name": "Cyclin-G1", "gene_name": "Ccng1", "organism": "Mouse", "refseq_name": "cyclin-G1", "refseq_ac": [ { "id": "NP_033961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033961", "type": "external" } ], "gene_names_uniprotkb": "Ccng1; Ccng", "gene_names_refseq": "Ccng1", "protein_names_uniprotkb": "Cyclin-G1; Cyclin-G", "protein_names_refseq": "cyclin-G1; cyclin-G", "tax_id": 10090, "disease": "ovarian serous carcinoma (Disease Ontology:DOID:0050933); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); head and neck cancer (Disease Ontology:DOID:11934); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); localized osteosarcoma (Disease Ontology:DOID:3356); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:12450); (R-MMU-6804757)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "25428506;25605945;30084848;30779550;34203471;34428180;7957050;8626390;8887688;9441755;9696022", "class_list": "", "function": "May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54779", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006949 syncytium formation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51945-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56203-1", "uniprot_id": [ { "id": "CATW_MOUSE", "url": "https://www.uniprot.org/uniprot/P56203", "type": "external" } ], "mass": 42120.0, "length": 371, "protein_name": "Cathepsin W", "gene_name": "Ctsw", "organism": "Mouse", "refseq_name": "cathepsin W preproprotein", "refseq_ac": [ { "id": "NP_034115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034115", "type": "external" } ], "gene_names_uniprotkb": "Ctsw", "gene_names_refseq": "Ctsw; lymphopain", "protein_names_uniprotkb": "Cathepsin W; 3.4.22.-; Lymphopain", "protein_names_refseq": "cathepsin W preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13041); (R-MMU-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15087452;21750661;35867415;9823953", "class_list": "", "function": "MCtsW does not have a unique role in target cell apoptosis or cytotoxic cell survival in vitro., [RefSeq, PubMed]; May have a specific function in the mechanism or regulation of T-cell cytolytic activity., [UniProtKB]; Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza., [RefSeq, PubMed]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of the encoded protein is upregulated following lymphocyte activation. Data from a human cell line suggests that the encoded enzyme may be important for viral entry into host cells. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56389-1", "uniprot_id": [ { "id": "CDD_MOUSE", "url": "https://www.uniprot.org/uniprot/P56389", "type": "external" } ], "mass": 16131.0, "length": 146, "protein_name": "Cytidine deaminase", "gene_name": "Cda", "organism": "Mouse", "refseq_name": "cytidine deaminase", "refseq_ac": [ { "id": "NP_082452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082452", "type": "external" } ], "gene_names_uniprotkb": "Cda; Cdd", "gene_names_refseq": "2210401N16Rik; Cda", "protein_names_uniprotkb": "Cytidine deaminase; 3.5.4.5; Cytidine aminohydrolase", "protein_names_refseq": "cytidine aminohydrolase; cytidine deaminase", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:72269); (R-MMU-6798695); (R-MMU-73614)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16784234;27461566;37086201", "class_list": "", "function": "Data indicate that a combination cytosine deaminase (CDA)/uracil phosphoribosyltransferase protein (UPRT)-expressing adipose tissue-derived mesenchymal stem cells (AT-MSCs) with lysomustine has a superior antitumor effect in the lung carcinoma model compared to monotherapies with transfected AT-MSCs or lysomustine alone., [RefSeq, PubMed]; Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification., [RefSeq, PubMed]; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7V3", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.13", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001882 nucleoside binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0044206 UMP salvage;GO:0071217 cellular response to external biotic stimulus;GO:0006248 CMP catabolic process;GO:0006249 dCMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56389-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59862-1", "uniprot_id": [ { "id": "CAD26_MOUSE", "url": "https://www.uniprot.org/uniprot/P59862", "type": "external" } ], "mass": 85084.0, "length": 763, "protein_name": "Cadherin-like protein 26", "gene_name": "Cdh26", "organism": "Mouse", "refseq_name": "cadherin-like protein 26 isoform b precursor", "refseq_ac": [ { "id": "NP_001278118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278118", "type": "external" } ], "gene_names_uniprotkb": "Cdh26; Gm1010", "gene_names_refseq": "Cdh26; Gm1010", "protein_names_uniprotkb": "Cadherin-like protein 26", "protein_names_refseq": "cadherin-like protein 26 isoform b precursor; cadherin-like protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:381409)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "35930423;36069256", "class_list": "", "function": "Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation., [UniProtKB, UniProtKB]; Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015630 microtubule cytoskeleton;GO:0016342 catenin complex", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59862-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00609-1", "uniprot_id": [ { "id": "CD80_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00609", "type": "external" } ], "mass": 34590.0, "length": 306, "protein_name": "T-lymphocyte activation antigen CD80", "gene_name": "Cd80", "organism": "Mouse", "refseq_name": "T-lymphocyte activation antigen CD80 precursor", "refseq_ac": [ { "id": "NP_033985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033985", "type": "external" } ], "gene_names_uniprotkb": "Cd80; B7", "gene_names_refseq": "B71; Cd28l; Cd80; Ly-53; Ly53; MIC17; TSA1", "protein_names_uniprotkb": "T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7", "protein_names_refseq": "B7 protein; T-lymphocyte activation antigen CD80 precursor; activation B7-1 antigen", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); kidney failure (Disease Ontology:DOID:1074); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); demyelinating disease (Disease Ontology:DOID:3213); periodontal disease (Disease Ontology:DOID:3388); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12519); (R-MMU-1257604); (R-MMU-389356); (R-MMU-389357); (R-MMU-389359); (R-MMU-389513); (R-MMU-6811558)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "16339518;1714935;19656770;22450810;34428180;38376148;38677291;39339855;7513163;7686531", "class_list": "", "function": "Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels., [RefSeq, PubMed]; CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment., [RefSeq, PubMed]; Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:16339518, PubMed:1714935). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:16339518). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (By similarity). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (By similarity). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (By similarity). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (By similarity). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (PubMed:22450810)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Presence of CD80 and Absence of LAT in Modulating Cellular Infiltration and HSV-1 Latency. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q61332", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0098636 protein complex involved in cell adhesion", "go_biological_process": "GO:0002710 negative regulation of T cell mediated immunity;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q00609-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08331-1", "uniprot_id": [ { "id": "CALB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08331", "type": "external" } ], "mass": 31373.0, "length": 271, "protein_name": "Calretinin", "gene_name": "Calb2", "organism": "Mouse", "refseq_name": "calretinin isoform 1", "refseq_ac": [ { "id": "NP_031612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031612", "type": "external" } ], "gene_names_uniprotkb": "Calb2", "gene_names_refseq": "CR; Calb2", "protein_names_uniprotkb": "Calretinin; CR", "protein_names_refseq": "calretinin isoform 1; calretinin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12308)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10220453;33488348;35165172;8255773;9387877", "class_list": "", "function": "Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (PubMed:10220453, PubMed:35165172). During embryonic development, it facilitates neuronal differentiation and maturation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60964;Q9JM81", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043195 terminal bouton;GO:0045202 synapse", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0048167 regulation of synaptic plasticity;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08331-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VF22-1", "uniprot_id": [ { "id": "CC138_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VF22", "type": "external" } ], "mass": 77947.0, "length": 680, "protein_name": "Coiled-coil domain-containing protein 138", "gene_name": "Ccdc138", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 138", "refseq_ac": [ { "id": "NP_001156428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156428", "type": "external" } ], "gene_names_uniprotkb": "Ccdc138", "gene_names_refseq": "6230424H07Rik; Ccdc138", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 138", "protein_names_refseq": "coiled-coil domain-containing protein 138", "tax_id": 10090, "disease": "", "pathway": " (mmu:76138)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG93", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VF22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149G0-1", "uniprot_id": [ { "id": "CB068_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149G0", "type": "external" } ], "mass": 18643.0, "length": 166, "protein_name": "UPF0561 protein C2orf68 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0561 protein C2orf68 homolog", "refseq_ac": [ { "id": "NP_080972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080972", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "0610030E20Rik; 1500031N04Rik; 2810411C16Rik", "protein_names_uniprotkb": "UPF0561 protein C2orf68 homolog", "protein_names_refseq": "UPF0561 protein C2orf68 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68364)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCK6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q149G0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTL0-1", "uniprot_id": [ { "id": "CC038_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTL0", "type": "external" } ], "mass": 39532.0, "length": 348, "protein_name": "Uncharacterized protein C3orf38 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C3orf38 homolog", "refseq_ac": [ { "id": "NP_080549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080549", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4930453N24Rik; din", "protein_names_uniprotkb": "Uncharacterized protein C3orf38 homolog", "protein_names_refseq": "uncharacterized protein C3orf38 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67609)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in apoptosis regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C482;Q8VE03", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TTL0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZI6-1", "uniprot_id": [ { "id": "CCNJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZI6", "type": "external" } ], "mass": 43488.0, "length": 379, "protein_name": "Cyclin-J", "gene_name": "Ccnj", "organism": "Mouse", "refseq_name": "cyclin-J", "refseq_ac": [ { "id": "NP_766427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766427", "type": "external" } ], "gene_names_uniprotkb": "Ccnj", "gene_names_refseq": "Ccnj; D430039C20Rik", "protein_names_uniprotkb": "Cyclin-J", "protein_names_refseq": "cyclin-J", "tax_id": 10090, "disease": "", "pathway": " (mmu:240665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1ED41;Q8BIY5", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TZI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UR78-1", "uniprot_id": [ { "id": "NICOL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UR78", "type": "external" } ], "mass": 9806.0, "length": 90, "protein_name": "NELL2-interacting cell ontogeny regulator 1", "gene_name": "Nicol1", "organism": "Mouse", "refseq_name": "NELL2-interacting cell ontogeny regulator 1 precursor", "refseq_ac": [ { "id": "NP_001297475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297475", "type": "external" } ], "gene_names_uniprotkb": "Nicol1; Gm1673", "gene_names_refseq": "Gm1673; NICOL; Nicol1", "protein_names_uniprotkb": "NELL2-interacting cell ontogeny regulator 1; NELL2-interacting cofactor for lumicrine signaling; NICOL", "protein_names_refseq": "NELL2-interacting cell ontogeny regulator 1 precursor; NELL2-interacting cofactor for lumicrine signaling; neuropeptide-like protein C4orf48 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:381633)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21287218;21750661;37095084;38625739", "class_list": "", "function": "The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production (PubMed:38625739). Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation (PubMed:38625739). Also binds to the 3'-UTR of ACTA2 (PubMed:38625739). Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation (PubMed:37095084)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJP7;Q3V2U0", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UR78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0A6-1", "uniprot_id": [ { "id": "CB078_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0A6", "type": "external" } ], "mass": 93729.0, "length": 857, "protein_name": "Uncharacterized protein C2orf78 homolog", "gene_name": "Gm5592", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf78 homolog", "refseq_ac": [ { "id": "NP_001028954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028954", "type": "external" } ], "gene_names_uniprotkb": "Gm5592", "gene_names_refseq": "EG434172; Gm5592", "protein_names_uniprotkb": "Uncharacterized protein C2orf78 homolog", "protein_names_refseq": "uncharacterized protein C2orf78 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:434172)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW58", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V0A6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63811-1", "uniprot_id": [ { "id": "CANB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63811", "type": "external" } ], "mass": 20659.0, "length": 179, "protein_name": "Calcineurin subunit B type 2", "gene_name": "Ppp3r2", "organism": "Mouse", "refseq_name": "calcineurin subunit B type 2", "refseq_ac": [ { "id": "NP_001004025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004025", "type": "external" } ], "gene_names_uniprotkb": "Ppp3r2", "gene_names_refseq": "CaNB2; CnB2; Ppp3r2", "protein_names_uniprotkb": "Calcineurin subunit B type 2; Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 regulatory subunit B beta isoform", "protein_names_refseq": "PP2B beta 2; calcineurin B subunit; calcineurin subunit B type 2; protein phosphatase 2B regulatory subunit 2", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (mmu:19059)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1325794;16286645;28383548;31900494", "class_list": "", "function": "Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression., [RefSeq, PubMed]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, UniProtKB]; Surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade;GO:0007341 penetration of zona pellucida;GO:1905665 positive regulation of calcium ion import across plasma membrane;GO:1905949 negative regulation of calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63811-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64389-1", "uniprot_id": [ { "id": "CD52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64389", "type": "external" } ], "mass": 7798.0, "length": 74, "protein_name": "CAMPATH-1 antigen", "gene_name": "Cd52", "organism": "Mouse", "refseq_name": "CAMPATH-1 antigen precursor", "refseq_ac": [ { "id": "NP_038734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038734", "type": "external" } ], "gene_names_uniprotkb": "Cd52; Cdw52; Mb7", "gene_names_refseq": "B7-Ag; B7; CAMPATH-1; CLS1; Cd52; MB7", "protein_names_uniprotkb": "CAMPATH-1 antigen; Lymphocyte differentiation antigen B7", "protein_names_refseq": "CAMPATH-1 antigen precursor; CAMPATH-1 antigen; lymphocyte differentiation antigen B7", "tax_id": 10090, "disease": "", "pathway": " (mmu:23833); (R-MMU-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2147207;33705353;7515288", "class_list": "", "function": "High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes., [RefSeq, PubMed]; May play a role in carrying and orienting carbohydrate, as well as having a more specific role., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097225 sperm midpiece;GO:0098552 side of membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64389-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDJ1-1", "uniprot_id": [ { "id": "CAHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDJ1", "type": "external" } ], "mass": 143812.0, "length": 1288, "protein_name": "VWFA and cache domain-containing protein 1", "gene_name": "Cachd1", "organism": "Mouse", "refseq_name": "VWFA and cache domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_932154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932154", "type": "external" } ], "gene_names_uniprotkb": "Cachd1; Kiaa1573; Vwcd1", "gene_names_refseq": "1190007F10Rik; B430218L07Rik; Cachd1; Vwcd1; mKIAA1573", "protein_names_uniprotkb": "VWFA and cache domain-containing protein 1; Cache domain-containing protein 1", "protein_names_refseq": "VWFA and cache domain-containing protein 1 precursor; VWFA and cache domain-containing protein 1; von Willebrand factor type A and cache domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320508)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31908000;37828378", "class_list": "", "function": "May regulate voltage-dependent calcium channels., [UniProtKB, UniProtKB, UniProtKB]; Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2A8W3;Q6PFZ0;Q6ZPM4;Q8BNP3", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PDJ1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPZ8-1", "uniprot_id": [ { "id": "CBPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPZ8", "type": "external" } ], "mass": 47385.0, "length": 419, "protein_name": "Carboxypeptidase A1", "gene_name": "Cpa1", "organism": "Mouse", "refseq_name": "carboxypeptidase A1 preproprotein", "refseq_ac": [ { "id": "NP_079626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079626", "type": "external" } ], "gene_names_uniprotkb": "Cpa1", "gene_names_refseq": "0910001L12Rik; Cpa1; Cpa", "protein_names_uniprotkb": "Carboxypeptidase A1; 3.4.17.1", "protein_names_refseq": "carboxypeptidase A1 preproprotein", "tax_id": 10090, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:109697)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;36210013", "class_list": "", "function": "Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro., [UniProtKB, UniProtKB]; This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008238 exopeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0046686 response to cadmium ion;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X53-1", "uniprot_id": [ { "id": "CC116_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X53", "type": "external" } ], "mass": 59879.0, "length": 541, "protein_name": "Coiled-coil domain-containing protein 116", "gene_name": "Ccdc116", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 116 isoform 1", "refseq_ac": [ { "id": "NP_001293098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293098", "type": "external" } ], "gene_names_uniprotkb": "Ccdc116", "gene_names_refseq": "4930432J16Rik; Ccdc116", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 116", "protein_names_refseq": "coiled-coil domain-containing protein 116 isoform 1; coiled-coil domain-containing protein 116", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:76872)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFY7;Q9D5J4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80X53-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGK9-1", "uniprot_id": [ { "id": "CC018_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGK9", "type": "external" } ], "mass": 17721.0, "length": 164, "protein_name": "Uncharacterized protein C3orf18 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C3orf18 homolog", "refseq_ac": [ { "id": "NP_780695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780695", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "6430571L13Rik", "protein_names_uniprotkb": "Uncharacterized protein C3orf18 homolog", "protein_names_refseq": "uncharacterized protein C3orf18 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:235599)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUH0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BGK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIS8-1", "uniprot_id": [ { "id": "CC126_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIS8", "type": "external" } ], "mass": 15590.0, "length": 140, "protein_name": "Coiled-coil domain-containing protein 126", "gene_name": "Ccdc126", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 126 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001298041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298041", "type": "external" } ], "gene_names_uniprotkb": "Ccdc126", "gene_names_refseq": "6330407D12Rik; Ccdc126", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 126", "protein_names_refseq": "coiled-coil domain-containing protein 126 isoform 2 precursor; coiled-coil domain-containing protein 126", "tax_id": 10090, "disease": "", "pathway": " (mmu:57895)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXH2;Q501L9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BIS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL00-1", "uniprot_id": [ { "id": "CDHR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL00", "type": "external" } ], "mass": 92084.0, "length": 831, "protein_name": "Cadherin-related family member 3", "gene_name": "Cdhr3", "organism": "Mouse", "refseq_name": "cadherin-related family member 3 precursor", "refseq_ac": [ { "id": "NP_001019649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019649", "type": "external" } ], "gene_names_uniprotkb": "Cdhr3; Cdh28", "gene_names_refseq": "1110049B09Rik; Cdh28; Cdhr3", "protein_names_uniprotkb": "Cadherin-related family member 3; Cadherin-like protein 28", "protein_names_refseq": "cadherin-like protein 28; cadherin-related family member 3 precursor", "tax_id": 10090, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); allergic disease (Disease Ontology:DOID:1205); obstructive lung disease (Disease Ontology:DOID:2320); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:68764)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;35820727", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 4, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RSL6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BL00-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMD5-1", "uniprot_id": [ { "id": "CDAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMD5", "type": "external" } ], "mass": 59062.0, "length": 523, "protein_name": "dCTP deaminase", "gene_name": "Cdadc1", "organism": "Mouse", "refseq_name": "cytidine and dCMP deaminase domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001162007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162007", "type": "external" } ], "gene_names_uniprotkb": "Cdadc1", "gene_names_refseq": "2310010M10Rik; Cdadc1; NYD-SP15", "protein_names_uniprotkb": "dCTP deaminase; 3.5.4.13; Cytidine and dCMP deaminase domain-containing protein 1; Deoxycytidine triphosphate deaminase; Testis development protein NYD-SP15", "protein_names_refseq": "cytidine and dCMP deaminase domain-containing protein 1 isoform 1; cytidine and dCMP deaminase domain-containing protein 1; cytidine deaminase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71891)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16955368;21750661;34428180;40324085;40504152", "class_list": "", "function": "Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis., [UniProtKB, UniProtKB]; Catalyzes the deamination of dCTP to dUTP. Can also catalyze the deamination of CTP but with a strong preference for dCTP (in vitro). Does not deaminate 5-methyl-dCTP, cytidin or deoxycytidine. May play an important role in testicular development and spermatogenesis., [UniProtKB, UniProtKB]; NYD-SP15 protein plays an important role in testicular development and spermatogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYL2;Q8BYN1;Q8C014;Q922P4;Q99KL2;Q9D7F3", "ec_number_list": [ { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.5.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.13", "type": "external" } ], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070383 DNA cytosine deamination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMD5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMK5-1", "uniprot_id": [ { "id": "CC184_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMK5", "type": "external" } ], "mass": 20184.0, "length": 191, "protein_name": "Coiled-coil domain-containing protein 184", "gene_name": "Ccdc184", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 184", "refseq_ac": [ { "id": "NP_808384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808384", "type": "external" } ], "gene_names_uniprotkb": "Ccdc184", "gene_names_refseq": "5630400A08; Ccdc184", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 184", "protein_names_refseq": "coiled-coil domain-containing protein 184", "tax_id": 10090, "disease": "", "pathway": " (mmu:239650)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBF4;Q8BV27", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BMK5-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BN57-1", "uniprot_id": [ { "id": "MISO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BN57", "type": "external" } ], "mass": 33668.0, "length": 294, "protein_name": "Mitochondrial inner membrane subdomain organizer 1", "gene_name": "Miso1", "organism": "Mouse", "refseq_name": "protein C3orf33 homolog isoform 1", "refseq_ac": [ { "id": "NP_808524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808524", "type": "external" } ], "gene_names_uniprotkb": "Miso1", "gene_names_refseq": "E130311K13Rik; Miso1", "protein_names_uniprotkb": "Mitochondrial inner membrane subdomain organizer 1", "protein_names_refseq": "protein C3orf33 homolog isoform 1; protein C3orf33 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:329659)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;30059200;41398051", "class_list": "", "function": "Regulates mitochondrial morphology and mitochondrial DNA (mtDNA) homeostasis (PubMed:41398051). Promotes the formation of specialized mitochondrial subdomains called small MTFP1-enriched mitochondria (SMEM) (By similarity). Negatively regulates mitochondrial fusion by excluding fusion coordinator OPA1 from SMEM (By similarity). Recruits mtDNA, potentially through interaction with SSBP1, and facilitates mtDNA transport to the mitochondrial periphery (By similarity). Also recruits other proteins, including PHB1, PHB2 and MTFP1, into SMEM which promotes peripheral mitochondrial fission, facilitating lysosome-mediated clearance of damaged mtDNA via mitophagy (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059W9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BN57-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5S3-1", "uniprot_id": [ { "id": "CC022_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5S3", "type": "external" } ], "mass": 15533.0, "length": 137, "protein_name": "Uncharacterized protein C3orf22 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C3orf22 homolog", "refseq_ac": [ { "id": "NP_808406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808406", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "BC048671", "protein_names_uniprotkb": "Uncharacterized protein C3orf22 homolog", "protein_names_refseq": "uncharacterized protein C3orf22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:243535)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C9E8-1", "uniprot_id": [ { "id": "CAHM6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C9E8", "type": "external" } ], "mass": 34956.0, "length": 313, "protein_name": "Calcium homeostasis modulator protein 6", "gene_name": "Calhm6", "organism": "Mouse", "refseq_name": "calcium homeostasis modulator protein 6", "refseq_ac": [ { "id": "NP_780658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780658", "type": "external" } ], "gene_names_uniprotkb": "Calhm6; Fam26f", "gene_names_refseq": "A630077B13Rik; Calhm6; Fam26f; INAM", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 6; IFN regulatory factor 3-dependent NK-activating molecule; INAM; Protein FAM26F", "protein_names_refseq": "IFN regulatory factor 3-dependent NK-activating molecule; calcium homeostasis modulator protein 6; family with sequence similarity 26, member F; protein FAM26F", "tax_id": 10090, "disease": "", "pathway": " (mmu:215900)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21059856;25320282;34428180;36861806", "class_list": "", "function": "INAM plays a critical role in IFN-gamma production by NK cells., [RefSeq, PubMed]; Pore-forming subunit of an ATP-permeable channel (PubMed:21059856, PubMed:36861806). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (PubMed:21059856, PubMed:36861806). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0022832 voltage-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:1904669 ATP export;GO:0002727 regulation of natural killer cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C9E8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAB8-1", "uniprot_id": [ { "id": "CAST2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAB8", "type": "external" } ], "mass": 36112.0, "length": 329, "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "Castor2", "organism": "Mouse", "refseq_name": "cytosolic arginine sensor for mTORC1 subunit 2", "refseq_ac": [ { "id": "NP_109644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109644", "type": "external" } ], "gene_names_uniprotkb": "Castor2; Gatsl2; Gats", "gene_names_refseq": "7530428J21Rik; Castor2; Gatsl1; Gatsl2; Gats", "protein_names_uniprotkb": "Cytosolic arginine sensor for mTORC1 subunit 2; GATS-like protein 2", "protein_names_refseq": "GATS protein-like 2; GATS-like protein 1; GATS-like protein 2; cytosolic arginine sensor for mTORC1 subunit 2; opposite strand transcription unit to Stag3", "tax_id": 10090, "disease": "", "pathway": " (mmu:80909); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20484733", "class_list": "", "function": "Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7A9;Q9ER44", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1903577 cellular response to L-arginine;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CAB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDL9-1", "uniprot_id": [ { "id": "CCD87_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDL9", "type": "external" } ], "mass": 98467.0, "length": 855, "protein_name": "Coiled-coil domain-containing protein 87", "gene_name": "Ccdc87", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 87", "refseq_ac": [ { "id": "NP_997151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997151", "type": "external" } ], "gene_names_uniprotkb": "Ccdc87", "gene_names_refseq": "4931419P11Rik; Ccdc87", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 87", "protein_names_refseq": "coiled-coil domain-containing protein 87", "tax_id": 10090, "disease": "", "pathway": " (mmu:399599)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29733332;34428180", "class_list": "", "function": "Ccdc87 mRNA and protein were only expressed in testis. Ccdc87 expression first appeared at postnatal day 14 and remained at a relatively high level until adulthood. Male mice lacking Ccdc87 gene (Ccdc87-/-) were found to be subfertile., [RefSeq, PubMed]; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5W2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007338 single fertilization;GO:1905516 positive regulation of fertilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CDL9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZT2-1", "uniprot_id": [ { "id": "CCSAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZT2", "type": "external" } ], "mass": 28379.0, "length": 252, "protein_name": "Centriole, cilia and spindle-associated protein", "gene_name": "Ccsap", "organism": "Mouse", "refseq_name": "centriole, cilia and spindle-associated protein", "refseq_ac": [ { "id": "NP_082812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082812", "type": "external" } ], "gene_names_uniprotkb": "Ccsap", "gene_names_refseq": "1700054N08Rik; Ccsap", "protein_names_uniprotkb": "Centriole, cilia and spindle-associated protein", "protein_names_refseq": "centriole, cilia and spindle-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73420)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3E1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005929 cilium;GO:0030424 axon;GO:0005814 centriole", "go_biological_process": "GO:0051301 cell division;GO:1901673 regulation of mitotic spindle assembly;GO:1990755 mitotic spindle microtubule depolymerization;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QZT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3C1-1", "uniprot_id": [ { "id": "CB042_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3C1", "type": "external" } ], "mass": 64071.0, "length": 574, "protein_name": "Uncharacterized protein C2orf42 homolog", "gene_name": "C87436", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf42 homolog isoform 2", "refseq_ac": [ { "id": "NP_001230670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230670", "type": "external" } ], "gene_names_uniprotkb": "C87436", "gene_names_refseq": "C87436", "protein_names_uniprotkb": "Uncharacterized protein C2orf42 homolog", "protein_names_refseq": "uncharacterized protein C2orf42 homolog isoform 2; uncharacterized protein C2orf42 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:232196)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB16;Q8BK22;Q8BXH4;Q8R2Z4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R3C1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHI7-1", "uniprot_id": [ { "id": "DRC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHI7", "type": "external" } ], "mass": 58170.0, "length": 493, "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "Ccdc65; Drc2", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_705738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705738", "type": "external" } ], "gene_names_uniprotkb": "Ccdc65; Drc2; Ccdc65", "gene_names_refseq": "4933417K04Rik; Ccdc65; Drc2; NYD-SP28", "protein_names_uniprotkb": "Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65; Testis development protein NYD-SP28", "protein_names_refseq": "coiled-coil domain-containing protein 65; dynein regulatory complex subunit 2 isoform 1; dynein regulatory complex subunit 2; testis development protein NYD-SP28", "tax_id": 10090, "disease": "primary ciliary dyskinesia 27 (Disease Ontology:DOID:0110611)", "pathway": " (mmu:105833)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;21750661;35844805", "class_list": "", "function": "CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Ccdc65 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0007420 brain development;GO:0045184 establishment of protein localization;GO:0060271 cilium assembly;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KF0-1", "uniprot_id": [ { "id": "CAR14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KF0", "type": "external" } ], "mass": 113497.0, "length": 999, "protein_name": "Caspase recruitment domain-containing protein 14", "gene_name": "Card14", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 14", "refseq_ac": [ { "id": "NP_570956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570956", "type": "external" } ], "gene_names_uniprotkb": "Card14; Bimp2", "gene_names_refseq": "Bimp2; CARMA2; Card14", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 14; Bcl10-interacting MAGUK protein 2; Bimp2", "protein_names_refseq": "bcl10-interacting MAGUK protein 2; caspase recruitment domain-containing protein 14", "tax_id": 10090, "disease": "psoriasis 2 (Disease Ontology:DOID:0080475); pityriasis rubra pilaris (Disease Ontology:DOID:9212)", "pathway": " (mmu:170720)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11387339;29150564;29689250;29980436;39145956", "class_list": "", "function": "Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis., [UniProtKB, UniProtKB]; CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation., [RefSeq, PubMed]; Caspase recruitment domain family member 14 (Card14)(E138A/+) and Card14(DeltaQ136/+) mice develop spontaneous psoriasis-like skin inflammation, resulted from constitutively activated CARMA2 via self-aggregation leading to the enhanced activation of the IL-23-IL-17A cytokine axis. Card14(-/-) mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired IL-17A signaling in keratinoc..., [RefSeq, PubMed]; Hyperactivation of CARD14 alone is sufficient to orchestrate the complex immunopathogenesis that drives T helper type 17-mediated psoriasis skin disease in vivo., [RefSeq, PubMed]; In experimental models of psoriasis induced by either imiquimod cream or recombinant IL-23 injection, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032449 CBM complex;GO:0016235 aggresome", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99KF0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPZ3-1", "uniprot_id": [ { "id": "CA185_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPZ3", "type": "external" } ], "mass": 25707.0, "length": 230, "protein_name": "Uncharacterized protein C1orf185 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf185 homolog isoform 2", "refseq_ac": [ { "id": "NP_001186019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186019", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1700007J23Rik; 4930522H14Rik", "protein_names_uniprotkb": "Uncharacterized protein C1orf185 homolog", "protein_names_refseq": "uncharacterized protein C1orf185 homolog isoform 2; uncharacterized protein C1orf185 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAM0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CPZ3-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQL2-1", "uniprot_id": [ { "id": "CCER1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQL2", "type": "external" } ], "mass": 46213.0, "length": 403, "protein_name": "Coiled-coil domain-containing glutamate-rich protein 1", "gene_name": "Ccer1", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing glutamate-rich protein 1", "refseq_ac": [ { "id": "NP_080000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080000", "type": "external" } ], "gene_names_uniprotkb": "Ccer1", "gene_names_refseq": "4921510H08Rik; Ccer1", "protein_names_uniprotkb": "Coiled-coil domain-containing glutamate-rich protein 1", "protein_names_refseq": "coiled-coil domain-containing glutamate-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66716)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38081819", "class_list": "", "function": "Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D162-1", "uniprot_id": [ { "id": "CC167_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D162", "type": "external" } ], "mass": 11475.0, "length": 97, "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "Ccdc167", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 167 isoform 1", "refseq_ac": [ { "id": "NP_001157213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157213", "type": "external" } ], "gene_names_uniprotkb": "Ccdc167; 1110021J02Rik", "gene_names_refseq": "1110021J02Rik; Ccdc167", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 167", "protein_names_refseq": "coiled-coil domain-containing protein 167 isoform 1; coiled-coil domain-containing protein 167; transmembrane and coiled-coil domain-containing protein C6orf129 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68597)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQL8;Q8C3L9;Q8R1Y8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D162-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5Q8-1", "uniprot_id": [ { "id": "CA141_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5Q8", "type": "external" } ], "mass": 51672.0, "length": 446, "protein_name": "Uncharacterized protein C1orf141 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C1orf141 homolog isoform 2", "refseq_ac": [ { "id": "NP_001156966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156966", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4921539E11Rik", "protein_names_uniprotkb": "Uncharacterized protein C1orf141 homolog", "protein_names_refseq": "uncharacterized protein C1orf141 homolog isoform 2; uncharacterized protein C1orf141 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70941)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKQ4;Q3KN93;Q3KN94;Q3TTD9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5Q8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6N1-1", "uniprot_id": [ { "id": "CAH13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6N1", "type": "external" } ], "mass": 29522.0, "length": 262, "protein_name": "Carbonic anhydrase 13", "gene_name": "Ca13", "organism": "Mouse", "refseq_name": "carbonic anhydrase 13", "refseq_ac": [ { "id": "NP_078771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078771", "type": "external" } ], "gene_names_uniprotkb": "Ca13; Car13", "gene_names_refseq": "2310075C21Rik; Ca13; Car13", "protein_names_uniprotkb": "Carbonic anhydrase 13; 4.2.1.1; CA-XIII; Carbonate dehydratase XIII; Carbonic anhydrase XIII", "protein_names_refseq": "CA-XIII; carbonate dehydratase XIII; carbonic anhydrase 13; carbonic anhydrase XIII", "tax_id": 10090, "disease": "", "pathway": " (mmu:71934); (R-MMU-1475029)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14600151;17314045;19186056;19206230;20820888;23233153;31219806", "class_list": "", "function": "Car5b and Car13 showed the highest signals in the mouse harderian gland., [RefSeq, PubMed]; Catalyzes the reversible conversion of carbon dioxide to hydrogencarbonate/bicarbonate and thus is essential in the regulation of pH and metabolic processes., [UniProtKB, PubMed, PubMed]; During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBM2", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D6N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9C6-1", "uniprot_id": [ { "id": "CC182_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9C6", "type": "external" } ], "mass": 17461.0, "length": 152, "protein_name": "Coiled-coil domain-containing protein 182", "gene_name": "Ccdc182", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 182", "refseq_ac": [ { "id": "NP_083135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083135", "type": "external" } ], "gene_names_uniprotkb": "Ccdc182", "gene_names_refseq": "1700106J16Rik; Ccdc182", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 182", "protein_names_refseq": "coiled-coil domain-containing protein 182; coiled-coil domain-containing protein ENSP00000299415 homolog; novel tropomyosin domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74297)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19301398", "class_list": "", "function": "1700106J16Rik and Sprr2d may have important roles in early gonad development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9C6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAA3-1", "uniprot_id": [ { "id": "CD036_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAA3", "type": "external" } ], "mass": 13552.0, "length": 117, "protein_name": "Uncharacterized protein C4orf36 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C4orf36 homolog", "refseq_ac": [ { "id": "NP_001157022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157022", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1700016H13Rik", "protein_names_uniprotkb": "Uncharacterized protein C4orf36 homolog", "protein_names_refseq": "uncharacterized protein C4orf36 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74218)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ66-1", "uniprot_id": [ { "id": "CDC20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ66", "type": "external" } ], "mass": 54816.0, "length": 499, "protein_name": "Cell division cycle protein 20 homolog", "gene_name": "Cdc20", "organism": "Mouse", "refseq_name": "cell division cycle protein 20 homolog", "refseq_ac": [ { "id": "NP_075712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075712", "type": "external" } ], "gene_names_uniprotkb": "Cdc20", "gene_names_refseq": "2310042N09Rik; Cdc20; p55CDC", "protein_names_uniprotkb": "Cell division cycle protein 20 homolog; mmCdc20; p55CDC", "protein_names_refseq": "cell division cycle 20 homolog; cell division cycle protein 20 homolog; mmCdc20", "tax_id": 10090, "disease": "", "pathway": " (mmu:107995); (R-MMU-141405); (R-MMU-141430); (R-MMU-141444); (R-MMU-174048); (R-MMU-174113); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176417); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-5689880); (R-MMU-68877); (R-MMU-9648025); (R-MMU-983168)", "pathway_count": 21, "publication_count": 13, "publication_id_list": "15280373;15526037;19900895;21750661;22014574;25428506;27802388;30084848;30779550;31219806;32666501;34298015;34428180", "class_list": "", "function": "Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (By similarity). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (PubMed:32666501). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (By similarity). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (PubMed:19900895). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (PubMed:19900895). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (PubMed:34298015). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (PubMed:34298015). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGP1;Q8BPG4;Q99LK3", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0016579 protein deubiquitination;GO:0030154 cell differentiation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JJ66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJA7-1", "uniprot_id": [ { "id": "CCNL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJA7", "type": "external" } ], "mass": 58005.0, "length": 518, "protein_name": "Cyclin-L2", "gene_name": "Ccnl2", "organism": "Mouse", "refseq_name": "cyclin-L2 isoform 1", "refseq_ac": [ { "id": "NP_997561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997561", "type": "external" } ], "gene_names_uniprotkb": "Ccnl2; Ania6b; MNCb-5160", "gene_names_refseq": "1700010A01Rik; 1810019L15Rik; 2010319M22Rik; Ania-6b; Ccnl2; HCLA-150; Pcee; SB138", "protein_names_uniprotkb": "Cyclin-L2; Cyclin Ania-6b; PCEE; Paneth cell-enhanced expression protein", "protein_names_refseq": "cyclin Ania-6b; cyclin-L2 isoform 1; paneth cell enhanced expression; paneth cell-enhanced expression protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56036)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11683997;14684736;17261272;18216018;19785986;21183079;21750661;25605945;30084848;30779550;34428180;8838426", "class_list": "", "function": "Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing., [UniProtKB, UniProtKB]; These data suggest that overexpression of CCNL2 inhibited proliferation and differentiation of mouse embryonic carcinoma P19 cells and induced them to undergo apoptosis, possibly through the Wnt signal transduction pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AD95;A2RSY2;Q5XK66;Q60995;Q8C136;Q8CIJ8;Q99L73;Q9QXH5", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0180038 cyclin L-CDK11 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JJA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJN5-1", "uniprot_id": [ { "id": "CBPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJN5", "type": "external" } ], "mass": 51845.0, "length": 457, "protein_name": "Carboxypeptidase N catalytic chain", "gene_name": "Cpn1", "organism": "Mouse", "refseq_name": "carboxypeptidase N catalytic chain precursor", "refseq_ac": [ { "id": "NP_109628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109628", "type": "external" } ], "gene_names_uniprotkb": "Cpn1", "gene_names_refseq": "0610011F20Rik; CPN; Cpn1", "protein_names_uniprotkb": "Carboxypeptidase N catalytic chain; 3.4.17.3; CPN; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit", "protein_names_refseq": "anaphylatoxin inactivator; carboxypeptidase N catalytic chain precursor; carboxypeptidase N catalytic chain; carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1, 50kD; kininase I", "tax_id": 10090, "disease": "carboxypeptidase N deficiency (Disease Ontology:DOID:0111583)", "pathway": " (mmu:93721); (R-MMU-977606)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10878383;11342641;15718415;34626062", "class_list": "", "function": "Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice., [RefSeq, PubMed]; Carboxypeptidase N regulates the biologic activity of SDF-1alpha by reducing the chemokine-specific activity, [RefSeq, PubMed]; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91WM9", "ec_number_list": [ { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" }, { "id": "3.4.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0051384 response to glucocorticoid;GO:0006518 peptide metabolic process;GO:0030163 protein catabolic process;GO:0010815 bradykinin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJN5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKC0-1", "uniprot_id": [ { "id": "CCL24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKC0", "type": "external" } ], "mass": 12871.0, "length": 119, "protein_name": "C-C motif chemokine 24", "gene_name": "Ccl24", "organism": "Mouse", "refseq_name": "C-C motif chemokine 24 precursor", "refseq_ac": [ { "id": "NP_062523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062523", "type": "external" } ], "gene_names_uniprotkb": "Ccl24; Scya24", "gene_names_refseq": "CKb-6; Ccl24; MPIF-2; Scya24", "protein_names_uniprotkb": "C-C motif chemokine 24; Eosinophil chemotactic protein 2; Eotaxin-2; Small-inducible cytokine A24", "protein_names_refseq": "C-C motif chemokine 24 precursor; C-C motif chemokine 24; CC chemokine CCL24; chemokine (C-C motif) ligand 24; eosinophil chemotactic protein 2; eotaxin-2; small-inducible cytokine A24", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (mmu:56221)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11067944;15647285;16102831;16210640;28759611;32276966;34221188;37345655", "class_list": "", "function": "CCL24 Protects Renal Function by Controlling Inflammation in Podocytes. Publication Status: Online-Only, [RefSeq, PubMed]; CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis. Publication Status: Online-Only, [RefSeq, PubMed]; Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:15647285). Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Distinct acidic and basic residues within CCR3 determine both receptor expression and activation by the eotaxins., [RefSeq, PubMed]; M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis., [RefSeq, PubMed]; Results demonstrate a cooperative mechanism between interleukin-13 and eotaxin-2, where IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia., [RefSeq, PubMed]; TPL-2-regulated Ccl24 in CD11c+CD11b+ cells prevents accelerated type-2 mediated immunity to H. polygyrus. Publication Status: Online-Only, [RefSeq, PubMed]; The eotaxin-2 pathway plays a fundamental role in eosinophil recruitment during ovalbumin-induced experimental asthma., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding;GO:0031728 CCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JKC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R013-1", "uniprot_id": [ { "id": "CATF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R013", "type": "external" } ], "mass": 51661.0, "length": 462, "protein_name": "Cathepsin F", "gene_name": "Ctsf", "organism": "Mouse", "refseq_name": "cathepsin F precursor", "refseq_ac": [ { "id": "NP_063914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063914", "type": "external" } ], "gene_names_uniprotkb": "Ctsf", "gene_names_refseq": "Ctsf", "protein_names_uniprotkb": "Cathepsin F; 3.4.22.41", "protein_names_refseq": "cathepsin F precursor", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 13 (Disease Ontology:DOID:0110727)", "pathway": " (mmu:56464); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10318784;10876093;16508006;21309947;21750661;30899004;34428180", "class_list": "", "function": "Cathepsin F inactivation causes a lysosomal storage defect and progressive neurological features in mice, [RefSeq, PubMed]; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis., [UniProtKB]; This gene is known to be important for immune responses and may potentially regulate alcohol consumption., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUT4", "ec_number_list": [ { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0070013 intracellular organelle lumen", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9R013-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTP5-1", "uniprot_id": [ { "id": "CAD22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTP5", "type": "external" } ], "mass": 87953.0, "length": 813, "protein_name": "Cadherin-22", "gene_name": "Cdh22", "organism": "Mouse", "refseq_name": "cadherin-22 precursor", "refseq_ac": [ { "id": "NP_778153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778153", "type": "external" } ], "gene_names_uniprotkb": "Cdh22", "gene_names_refseq": "Cdh22", "protein_names_uniprotkb": "Cadherin-22; PB-cadherin; Pituitary and brain cadherin", "protein_names_refseq": "PB-cadherin; cadherin-22 precursor; pituitary and brain cadherin", "tax_id": 10090, "disease": "", "pathway": " (mmu:104010)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10398531;29063123;31041846", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues., [UniProtKB]; Glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells., [RefSeq, PubMed]; Janus kinase 2 protein (JAK2) and beta-catenin were found to interact with cadherin-22 (Cdh22) and involved in CDH22 signaling in female germ line stem cells (FGSCs)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "I7HIP9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WTP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUU7-1", "uniprot_id": [ { "id": "CATZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUU7", "type": "external" } ], "mass": 33996.0, "length": 306, "protein_name": "Cathepsin Z", "gene_name": "Ctsz", "organism": "Mouse", "refseq_name": "cathepsin Z preproprotein", "refseq_ac": [ { "id": "NP_071720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071720", "type": "external" } ], "gene_names_uniprotkb": "Ctsz", "gene_names_refseq": "CTSX; Ctsz; D2Wsu143e", "protein_names_uniprotkb": "Cathepsin Z; 3.4.18.1", "protein_names_refseq": "cathepsin X; cathepsin Z preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:64138); (R-MMU-2022377); (R-MMU-204005); (R-MMU-432720); (R-MMU-5694530); (R-MMU-6798695)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10760573;12186844;29562282;30059200;30899004;31219806;31281521;34428180;34864055;34989869;37507081;37828378", "class_list": "", "function": "Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Extracellular cathepsin Z signals through the alpha5 integrin and augments NLRP3 inflammasome activation., [RefSeq, PubMed]; Regulation of the phagosomal CatZ, CatB, CatL and CatS contents during dendritic cell activation, [RefSeq, PubMed]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004180 carboxypeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0030426 growth cone", "go_biological_process": "GO:0006508 proteolysis;GO:0010757 negative regulation of plasminogen activation;GO:0051603 proteolysis involved in protein catabolic process;GO:0060441 epithelial tube branching involved in lung morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9WUU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0H0-1", "uniprot_id": [ { "id": "CDC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0H0", "type": "external" } ], "mass": 62770.0, "length": 564, "protein_name": "Cell division cycle 7-related protein kinase", "gene_name": "Cdc7", "organism": "Mouse", "refseq_name": "cell division cycle 7-related protein kinase isoform 1", "refseq_ac": [ { "id": "NP_001258495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258495", "type": "external" } ], "gene_names_uniprotkb": "Cdc7; Cdc7l1", "gene_names_refseq": "Cdc7l1; Cdc7; muCdc7", "protein_names_uniprotkb": "Cell division cycle 7-related protein kinase; 2.7.11.1; CDC7-related kinase; muCdc7", "protein_names_refseq": "CDC7-related kinase; cell division cycle 7-like 1; cell division cycle 7-related protein kinase isoform 1; cell division cycle 7-related protein kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:12545); (R-MMU-176187); (R-MMU-68962)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10199953;10517317;21750661;34428180;35508654;37584256;9722556", "class_list": "", "function": "CDC7-independent G1/S transition revealed by targeted protein degradation., [RefSeq, PubMed]; Cdc7 kinase is required for postnatal brain development., [RefSeq, PubMed]; Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUV1;Q9Z2Y7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0031431 Dbf4-dependent protein kinase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0H0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0M3-1", "uniprot_id": [ { "id": "CAD20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0M3", "type": "external" } ], "mass": 88998.0, "length": 801, "protein_name": "Cadherin-20", "gene_name": "Cdh20", "organism": "Mouse", "refseq_name": "cadherin-20 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035930", "type": "external" } ], "gene_names_uniprotkb": "Cdh20; Cdh7", "gene_names_refseq": "Cdh20; Cdh7", "protein_names_uniprotkb": "Cadherin-20; Cadherin-7", "protein_names_refseq": "cadherin-20 isoform 1 precursor; cadherin-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:23836)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10433813;15273735;22645316;30779550;35820727", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB]; Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0M3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04899-1", "uniprot_id": [ { "id": "CDK18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04899", "type": "external" } ], "mass": 51848.0, "length": 451, "protein_name": "Cyclin-dependent kinase 18", "gene_name": "Cdk18", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 18", "refseq_ac": [ { "id": "NP_032821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032821", "type": "external" } ], "gene_names_uniprotkb": "Cdk18; Pctaire3; Pctk3", "gene_names_refseq": "Cdk18; Ctk18; Pctk3", "protein_names_uniprotkb": "Cyclin-dependent kinase 18; 2.7.11.22; Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3", "protein_names_refseq": "PCTAIRE-motif protein kinase 3; cell division protein kinase 18; cyclin-dependent kinase 18; serine/threonine-protein kinase PCTAIRE-3", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231)", "pathway": " (mmu:18557)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1437147;19144319;21183079;21750661;24831015;30084848;32164329;33300544;34428180", "class_list": "", "function": "May play a role in signal transduction cascades in terminally differentiated cells., [UniProtKB]; The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1901987 regulation of cell cycle phase transition;GO:0031643 positive regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q04899-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QM76-1", "uniprot_id": [ { "id": "CC179_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QM76", "type": "external" } ], "mass": 7928.0, "length": 67, "protein_name": "Coiled-coil domain-containing protein 179", "gene_name": "Ccdc179", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 179", "refseq_ac": [ { "id": "NP_001182530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182530", "type": "external" } ], "gene_names_uniprotkb": "Ccdc179", "gene_names_refseq": "1700015G11Rik; Ccdc179", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 179", "protein_names_refseq": "coiled-coil domain-containing protein 179", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503036)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QM76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37217-1", "uniprot_id": [ { "id": "CD69_MOUSE", "url": "https://www.uniprot.org/uniprot/P37217", "type": "external" } ], "mass": 22517.0, "length": 199, "protein_name": "Early activation antigen CD69", "gene_name": "Cd69", "organism": "Mouse", "refseq_name": "early activation antigen CD69", "refseq_ac": [ { "id": "NP_001028294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028294", "type": "external" } ], "gene_names_uniprotkb": "Cd69", "gene_names_refseq": "5830438K24Rik; AIM; Cd69; VEA", "protein_names_uniprotkb": "Early activation antigen CD69", "protein_names_refseq": "Very Early Activation Antigen; early activation antigen CD69", "tax_id": 10090, "disease": "", "pathway": " (mmu:12515)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16525420;20696842;21750661;38135026;38540778;38700335;8100776", "class_list": "glycogene", "function": "CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity., [RefSeq, PubMed]; Innate phase production of IFN-gamma by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs., [RefSeq, PubMed]; Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:20696842, PubMed:38540778). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (By similarity). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (PubMed:20696842). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT. Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (By similarity). In eosinophils, induces IL-10 production through the ERK1/2 pathway (PubMed:38540778). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:16525420)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0050728 negative regulation of inflammatory response;GO:0071466 cellular response to xenobiotic stimulus;GO:2000405 negative regulation of T cell migration;GO:0072678 T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P37217-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWD8-1", "uniprot_id": [ { "id": "CDK19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWD8", "type": "external" } ], "mass": 56570.0, "length": 501, "protein_name": "Cyclin-dependent kinase 19", "gene_name": "Cdk19", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 19 isoform 1", "refseq_ac": [ { "id": "NP_001161776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161776", "type": "external" } ], "gene_names_uniprotkb": "Cdk19; Cdc2l6; Kiaa1028", "gene_names_refseq": "2700084L06Rik; CDK11; Cdc2l6; Cdk19; mKIAA1028", "protein_names_uniprotkb": "Cyclin-dependent kinase 19; 2.7.11.22; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19", "protein_names_refseq": "CDC2-related protein kinase 6; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; cyclin-dependent kinase 19 isoform 1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221)", "pathway": " (mmu:78334)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;36545778;39927985;41123539", "class_list": "", "function": "CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium., [RefSeq, PubMed]; Component of the Mediator complex, a transcriptional coactivator required for regulated expression of nearly all RNA polymerase II-dependent genes. Acts as a molecular bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters through direct interactions with transcriptional regulators and serves as a scaffold for assembly of the pre-initiation complex with RNA polymerase II and general transcription factors. Contributes to phosphorylation of transcription factors and other substrates, including RNA polymerase II and the Notch1 intracellular domain (ICN1), thereby modulating gene expression programs (By similarity). Plays a role together with CDK8 in normal macrophage differentiation (PubMed:41123539)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TM1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:1990508 CKM complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BWD8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JLY1-1", "uniprot_id": [ { "id": "CF210_MOUSE", "url": "https://www.uniprot.org/uniprot/A0JLY1", "type": "external" } ], "mass": 65132.0, "length": 547, "protein_name": "Cilia- and flagella- associated protein 210", "gene_name": "Cfap210", "organism": "Mouse", "refseq_name": "cilia- and flagella- associated protein 210 isoform 1", "refseq_ac": [ { "id": "NP_001071152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071152", "type": "external" } ], "gene_names_uniprotkb": "Cfap210; Ccdc173", "gene_names_refseq": "4930525K21Rik; 4930578N16Rik; Ccdc173; Cfap210", "protein_names_uniprotkb": "Cilia- and flagella- associated protein 210; Coiled-coil domain-containing protein 173", "protein_names_refseq": "cilia- and flagella- associated protein 210 isoform 1; coiled-coil domain containing 173; coiled-coil domain-containing protein 173; protein CFAP210", "tax_id": 10090, "disease": "", "pathway": " (mmu:75051)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005879 axonemal microtubule;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0JLY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3M9-1", "uniprot_id": [ { "id": "CB080_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3M9", "type": "external" } ], "mass": 25767.0, "length": 231, "protein_name": "Uncharacterized protein C2orf80 homolog", "gene_name": "D630023F18Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C2orf80 homolog isoform 2", "refseq_ac": [ { "id": "NP_001272810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272810", "type": "external" } ], "gene_names_uniprotkb": "D630023F18Rik", "gene_names_refseq": "D630023F18Rik", "protein_names_uniprotkb": "Uncharacterized protein C2orf80 homolog", "protein_names_refseq": "uncharacterized protein C2orf80 homolog isoform 2; uncharacterized protein C2orf80 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:98303)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37507081", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C3M9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEK0-1", "uniprot_id": [ { "id": "CC50A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEK0", "type": "external" } ], "mass": 41061.0, "length": 364, "protein_name": "Cell cycle control protein 50A", "gene_name": "Tmem30a", "organism": "Mouse", "refseq_name": "cell cycle control protein 50A", "refseq_ac": [ { "id": "NP_598479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598479", "type": "external" } ], "gene_names_uniprotkb": "Tmem30a; Cdc50a; D9Wsu20e", "gene_names_refseq": "2010200I23Rik; Cdc50a; D9Wsu20e; Tmem30a", "protein_names_uniprotkb": "Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A", "protein_names_refseq": "P4-ATPase flippase complex beta subunit TMEM30A; cell cycle control protein 50A; transmembrane protein 30A", "tax_id": 10090, "disease": "", "pathway": " (mmu:69981); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21750661;22253360;22307598;22641037;22645316;23269685;24413176;26495903;29799007;30018401;30899004;33300544;34428180;37612668;37828378", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; CDC50A is present as a fully glycosylated protein in vivo, which presumes interaction with distinct P4 ATPases., [RefSeq, PubMed]; Knockdown of TMEM30A in renal tubular epithelial cells leads to reduced glucose absorption. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCJ5;Q3UDH8;Q8R0X6;Q8VEH1", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0045332 phospholipid translocation;GO:0036010 protein localization to endosome;GO:0006855 xenobiotic transmembrane transport;GO:0061092 positive regulation of phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q8VEK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06770-1", "uniprot_id": [ { "id": "CBG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06770", "type": "external" } ], "mass": 44769.0, "length": 397, "protein_name": "Corticosteroid-binding globulin", "gene_name": "Serpina6", "organism": "Mouse", "refseq_name": "corticosteroid-binding globulin precursor", "refseq_ac": [ { "id": "NP_031644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031644", "type": "external" } ], "gene_names_uniprotkb": "Serpina6; Cbg", "gene_names_refseq": "Cbg; Serpina6", "protein_names_uniprotkb": "Corticosteroid-binding globulin; CBG; Serpin A6; Transcortin", "protein_names_refseq": "corticosteroid-binding globulin precursor; corticosteroid-binding globulin; serine (or cysteine) proteinase inhibitor, clade A, member 6; serpin A6; transcortin", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030)", "pathway": " (mmu:12401); (R-MMU-194002); (R-MMU-9757110)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "16944957;17330941;21750661;24246737;25428506;26495903;26740625;26741814;30059200;30084848;30899004;37507081;39627609;7916682", "class_list": "", "function": "CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung. Publication Status: Online-Only, [RefSeq, PubMed]; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species., [UniProtKB]; The same gene encodes brain and liver corticosteroid-binding globulin, [RefSeq, PubMed]; This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005496 steroid binding;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008211 glucocorticoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q06770-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVB3-1", "uniprot_id": [ { "id": "CC175_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVB3", "type": "external" } ], "mass": 97122.0, "length": 822, "protein_name": "Coiled-coil domain-containing protein 175", "gene_name": "Ccdc175", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 175", "refseq_ac": [ { "id": "NP_082963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082963", "type": "external" } ], "gene_names_uniprotkb": "Ccdc175", "gene_names_refseq": "4930403N07Rik; Ccdc175", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 175", "protein_names_refseq": "coiled-coil domain-containing protein 175", "tax_id": 10090, "disease": "", "pathway": " (mmu:73936)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PVB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVD1-1", "uniprot_id": [ { "id": "CCD62_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVD1", "type": "external" } ], "mass": 79317.0, "length": 701, "protein_name": "Coiled-coil domain-containing protein 62", "gene_name": "Ccdc62", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 62", "refseq_ac": [ { "id": "NP_001128239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128239", "type": "external" } ], "gene_names_uniprotkb": "Ccdc62", "gene_names_refseq": "Ccdc62; G1-485-3; Gm150; repro29", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 62", "protein_names_refseq": "coiled-coil domain-containing protein 62", "tax_id": 10090, "disease": "spermatogenic failure 67 (Disease Ontology:DOID:0070566)", "pathway": " (mmu:208908)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28339613", "class_list": "", "function": "Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Also modulates progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (By similarity). Required for normal spermiogenesis (PubMed:28339613). It probably plays a role in acrosome formation (PubMed:28339613)., [UniProtKB, PubMed]; Required for maintenance for normal spermiogenesis and male fertility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6WEA5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007286 spermatid development;GO:0071392 cellular response to estradiol stimulus;GO:0030520 estrogen receptor signaling pathway;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PVD1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11609-1", "uniprot_id": [ { "id": "CD1D1_MOUSE", "url": "https://www.uniprot.org/uniprot/P11609", "type": "external" } ], "mass": 38554.0, "length": 336, "protein_name": "Antigen-presenting glycoprotein CD1d1", "gene_name": "Cd1d1", "organism": "Mouse", "refseq_name": "antigen-presenting glycoprotein CD1d1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_031665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031665", "type": "external" } ], "gene_names_uniprotkb": "Cd1d1; Cd1.1", "gene_names_refseq": "CD1.1; Cd1a; Cd1d1; Cd1d; Ly-38", "protein_names_uniprotkb": "Antigen-presenting glycoprotein CD1d1", "protein_names_refseq": "T-cell surface glycoprotein CD1d1; antigen-presenting glycoprotein CD1d1 isoform 1 precursor; antigen-presenting glycoprotein CD1d1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); dengue hemorrhagic fever (Disease Ontology:DOID:12206); urinary schistosomiasis (Disease Ontology:DOID:1394); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:12479); (R-MMU-198933)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11754812;16002697;16007091;16314439;16537470;1702817;21750661;2460336;30899004;33087357;38438948;38586879;38984869;9219685", "class_list": "glycogene", "function": "Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis., [RefSeq, PubMed]; Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and MR1-restricted T Cells in Clearing Bartonella Infection., [RefSeq, PubMed]; Ox-LDL-induced CD80[+] macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 49, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91XK9", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0042608 T cell receptor binding;GO:0030883 endogenous lipid antigen binding;GO:0030884 exogenous lipid antigen binding;GO:0071723 lipopeptide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0051135 positive regulation of NK T cell activation;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P11609-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQK5-1", "uniprot_id": [ { "id": "CCD93_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQK5", "type": "external" } ], "mass": 72603.0, "length": 629, "protein_name": "Coiled-coil domain-containing protein 93", "gene_name": "Ccdc93", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 93 isoform a", "refseq_ac": [ { "id": "NP_001020327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020327", "type": "external" } ], "gene_names_uniprotkb": "Ccdc93", "gene_names_refseq": "4633402D15Rik; 9230102M16Rik; Ccdc93", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 93", "protein_names_refseq": "coiled-coil domain-containing protein 93 isoform a; coiled-coil domain-containing protein 93", "tax_id": 10090, "disease": "", "pathway": " (mmu:70829)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (By similarity). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (By similarity). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX53", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006631 fatty acid metabolic process;GO:0015031 protein transport;GO:1905144 response to acetylcholine;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1S8-1", "uniprot_id": [ { "id": "CAN7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1S8", "type": "external" } ], "mass": 92564.0, "length": 813, "protein_name": "Calpain-7", "gene_name": "Capn7", "organism": "Mouse", "refseq_name": "calpain-7 isoform 1", "refseq_ac": [ { "id": "NP_033926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033926", "type": "external" } ], "gene_names_uniprotkb": "Capn7; Palbh", "gene_names_refseq": "Capn7; PalBH", "protein_names_uniprotkb": "Calpain-7; 3.4.22.-; PalB homolog; PalBH", "protein_names_refseq": "calpain-7 isoform 1; palB homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:12339); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10051333;11342116;14981075;21750661;22872234;25428506;26495903;29459744;30084848;31219806;34428180", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis, [RefSeq, PubMed]; Overexpression of CAPN7 in Ishikawa cells or in the uterus of mice inhibited embryo implantation in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0P9", "ec_number_list": [ { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0090541 MIT domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0010634 positive regulation of epithelial cell migration;GO:0097264 self proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R1S8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08074-1", "uniprot_id": [ { "id": "CBR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P08074", "type": "external" } ], "mass": 25958.0, "length": 244, "protein_name": "Carbonyl reductase [NADPH] 2", "gene_name": "Cbr2", "organism": "Mouse", "refseq_name": "carbonyl reductase [NADPH] 2", "refseq_ac": [ { "id": "NP_031647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031647", "type": "external" } ], "gene_names_uniprotkb": "Cbr2", "gene_names_refseq": "Cbr2; MLCR", "protein_names_uniprotkb": "Carbonyl reductase [NADPH] 2; 1.1.1.184; AP27; Adipocyte protein P27; LCR; Lung carbonyl reductase; NADPH-dependent carbonyl reductase 2", "protein_names_refseq": "AP27; LCR; NADPH-dependent carbonyl reductase 2; adipocyte protein P27; carbonyl reductase [NADPH] 2; lung carbonyl reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:12409)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21183079;21750661;2455724;25428506;30084848;34428180;37507081;7705352;8040004;8805511;8999926", "class_list": "", "function": "May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" } ], "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0004090 carbonyl reductase (NADPH) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08074-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18242-1", "uniprot_id": [ { "id": "CATD_MOUSE", "url": "https://www.uniprot.org/uniprot/P18242", "type": "external" } ], "mass": 44954.0, "length": 410, "protein_name": "Cathepsin D", "gene_name": "Ctsd", "organism": "Mouse", "refseq_name": "cathepsin D precursor", "refseq_ac": [ { "id": "NP_034113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034113", "type": "external" } ], "gene_names_uniprotkb": "Ctsd", "gene_names_refseq": "CD; CatD; Ctsd", "protein_names_uniprotkb": "Cathepsin D; 3.4.23.5", "protein_names_refseq": "cathepsin D precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); neuronal ceroid lipofuscinosis 10 (Disease Ontology:DOID:0110725); Alzheimer's disease (Disease Ontology:DOID:10652); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:13033); (R-MMU-1442490); (R-MMU-2022377); (R-MMU-2132295); (R-MMU-6798695); (R-MMU-77387)", "pathway_count": 6, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;11801660;16075062;16170054;16393994;17322886;21750661;2263503;2374732;26192747;26495903;28453791;29562282;30059200;30084848;30899004;31219806;31616917;32152506;34428180;37453647;37507081;39019115;39927985;40885482;8011168", "class_list": "", "function": "Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation., [UniProtKB, UniProtKB]; Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.23.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.15", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0016787 hydrolase activity;GO:0042277 peptide binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0097194 execution phase of apoptosis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P18242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3Q6-1", "uniprot_id": [ { "id": "MIX23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3Q6", "type": "external" } ], "mass": 16665.0, "length": 144, "protein_name": "Protein MIX23", "gene_name": "Mix23", "organism": "Mouse", "refseq_name": "protein MIX23 isoform 2", "refseq_ac": [ { "id": "NP_001152893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152893", "type": "external" } ], "gene_names_uniprotkb": "Mix23; Ccdc58", "gene_names_refseq": "A930007B11Rik; Ccdc58; Mix23", "protein_names_uniprotkb": "Protein MIX23; Coiled-coil domain-containing protein 58", "protein_names_refseq": "coiled-coil domain containing 58; coiled-coil domain-containing protein 58; protein MIX23 isoform 2; protein MIX23", "tax_id": 10090, "disease": "", "pathway": " (mmu:381045)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26495903;26740625;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXM5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R3Q6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53702-1", "uniprot_id": [ { "id": "CCHL_MOUSE", "url": "https://www.uniprot.org/uniprot/P53702", "type": "external" } ], "mass": 30978.0, "length": 272, "protein_name": "Holocytochrome c-type synthase", "gene_name": "Hccs", "organism": "Mouse", "refseq_name": "holocytochrome c-type synthase isoform 1", "refseq_ac": [ { "id": "NP_001317978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317978", "type": "external" } ], "gene_names_uniprotkb": "Hccs; Cchl", "gene_names_refseq": "CCHL; Hccs", "protein_names_uniprotkb": "Holocytochrome c-type synthase; 4.4.1.17; CCHL; Cytochrome c-type heme lyase", "protein_names_refseq": "cytochrome c-type heme lyase; holocytochrome c-type synthase isoform 1; holocytochrome c-type synthase", "tax_id": 10090, "disease": "linear skin defects with multiple congenital anomalies 1 (Disease Ontology:DOID:0111808); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (mmu:15159); (R-MMU-611105)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11668396;21750661;22645316;28135057;28528544;36288343;8661044", "class_list": "", "function": "Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice, [RefSeq, PubMed]; Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5G5", "ec_number_list": [ { "id": "4.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0018063 cytochrome c-heme linkage", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53702-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24860-1", "uniprot_id": [ { "id": "CCNB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P24860", "type": "external" } ], "mass": 48052.0, "length": 430, "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "Ccnb1", "organism": "Mouse", "refseq_name": "G2/mitotic-specific cyclin-B1", "refseq_ac": [ { "id": "NP_758505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758505", "type": "external" } ], "gene_names_uniprotkb": "Ccnb1; Ccn-2; Ccnb1-rs13; Cycb1; Cycb", "gene_names_refseq": "Ccnb1-rs13; Ccnb1-rs1; Ccnb1; CycB1; Cycb-4; Cycb-5; Cycb1-rs1", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B1", "protein_names_refseq": "G2/mitotic-specific cyclin-B1; cyclin B1, related sequence 13", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:268697); (R-MMU-174048); (R-MMU-176408); (R-MMU-176412); (R-MMU-176417); (R-MMU-2299718); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-2980767); (R-MMU-2995383); (R-MMU-3301854); (R-MMU-4419969); (R-MMU-6804114); (R-MMU-68875); (R-MMU-69273); (R-MMU-69478); (R-MMU-75035); (R-MMU-8852276); (R-MMU-8878166)", "pathway_count": 19, "publication_count": 13, "publication_id_list": "12525704;1280449;1387105;1836195;20485683;21750661;30084848;31219806;31599954;34428180;36210013;36852467;39093409", "class_list": "", "function": "Essential for the control of the cell cycle at the G2/M (mitosis) transition (By similarity). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (By similarity)., [UniProtKB, UniProtKB]; Essential for the control of the cell cycle at the G2/M (mitosis) transition., [UniProtKB, UniProtKB]; MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0005113 patched binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24860-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEB3-1", "uniprot_id": [ { "id": "MACIR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEB3", "type": "external" } ], "mass": 23130.0, "length": 207, "protein_name": "Macrophage immunometabolism regulator", "gene_name": "Macir", "organism": "Mouse", "refseq_name": "macrophage immunometabolism regulator", "refseq_ac": [ { "id": "NP_598586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598586", "type": "external" } ], "gene_names_uniprotkb": "Macir; D1Ertd622e", "gene_names_refseq": "D1Ertd622e; Macir", "protein_names_uniprotkb": "Macrophage immunometabolism regulator", "protein_names_refseq": "UNC119-binding protein C5orf30 homolog; UPF0684 protein C5orf30 homolog; macrophage immunometabolism regulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:52392)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22085962;25605945;26316022;34428180", "class_list": "", "function": "C5orf30 is a previously unidentified negative regulator of tissue damage in rheumatoid arthritis, and this protein may act by modulating the autoaggressive phenotype that is characteristic of synovial fibroblasts, [RefSeq, PubMed]; Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXG2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0006954 inflammatory response;GO:0015031 protein transport;GO:0050728 negative regulation of inflammatory response;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VEB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35646-1", "uniprot_id": [ { "id": "CAN6_MOUSE", "url": "https://www.uniprot.org/uniprot/O35646", "type": "external" } ], "mass": 74543.0, "length": 641, "protein_name": "Calpain-6", "gene_name": "Capn6", "organism": "Mouse", "refseq_name": "calpain-6", "refseq_ac": [ { "id": "NP_031629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031629", "type": "external" } ], "gene_names_uniprotkb": "Capn6; Capa6", "gene_names_refseq": "Capn6", "protein_names_uniprotkb": "Calpain-6", "protein_names_refseq": "calpain-6", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:12338); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17210638;20814968;21406564;22872234;31599954;31619317;37828378;9503024", "class_list": "", "function": "Calpain-6 deficiency reduced the percentage of ciliated cells and impaired sonic hedgehog signaling. It has been speculated that this defect might be associated with decreased levels of alpha-tubulin acetylation at lysine 40., [RefSeq, PubMed]; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM55", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0005876 spindle microtubule", "go_biological_process": "GO:0051493 regulation of cytoskeleton organization;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35646-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55233-1", "uniprot_id": [ { "id": "CER1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55233", "type": "external" } ], "mass": 30431.0, "length": 272, "protein_name": "Cerberus", "gene_name": "Cer1", "organism": "Mouse", "refseq_name": "cerberus precursor", "refseq_ac": [ { "id": "NP_034017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034017", "type": "external" } ], "gene_names_uniprotkb": "Cer1; Cerl; Cerr1", "gene_names_refseq": "Cer1; Cerl1; Cerl; Cerr1; cer-1", "protein_names_uniprotkb": "Cerberus; Cer-l; Cerberus-like protein; Cerberus-related protein", "protein_names_refseq": "cer-l; cerberus 1 homolog; cerberus homolog; cerberus precursor; cerberus-like protein; cerberus-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12622); (R-MMU-201451)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12431380;34428180;9431803;9501024;9600941", "class_list": "", "function": "Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35213", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0016015 morphogen activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development;GO:0008285 negative regulation of cell population proliferation;GO:0009952 anterior/posterior pattern specification;GO:0030514 negative regulation of BMP signaling pathway;GO:0042074 cell migration involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55233-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55237-1", "uniprot_id": [ { "id": "CD70_MOUSE", "url": "https://www.uniprot.org/uniprot/O55237", "type": "external" } ], "mass": 21919.0, "length": 195, "protein_name": "CD70 antigen", "gene_name": "Cd70", "organism": "Mouse", "refseq_name": "CD70 antigen", "refseq_ac": [ { "id": "NP_035747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035747", "type": "external" } ], "gene_names_uniprotkb": "Cd70; Cd27lg; Cd27l; Tnfsf7", "gene_names_refseq": "CD27LG; Cd27l; Cd70; Tnfsf7; Tnlg8a", "protein_names_uniprotkb": "CD70 antigen; CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7", "protein_names_refseq": "CD27 ligand; CD27-L; CD70 antigen; Ki-24 antigen; tumor necrosis factor ligand 8a; tumor necrosis factor ligand superfamily member 7", "tax_id": 10090, "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704)", "pathway": " (mmu:21948); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;37024479;37160118;38386557;9366422;9620608", "class_list": "", "function": "Cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity., [RefSeq, PubMed]; Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells., [UniProtKB, PubMed, PubMed]; Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction. Publication Status: Online-Only, [RefSeq, PubMed]; The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0097191 extrinsic apoptotic signaling pathway;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0042100 B cell proliferation;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O55237-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70578-1", "uniprot_id": [ { "id": "CCG1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70578", "type": "external" } ], "mass": 25120.0, "length": 223, "protein_name": "Voltage-dependent calcium channel gamma-1 subunit", "gene_name": "Cacng1", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-1 subunit", "refseq_ac": [ { "id": "NP_031608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031608", "type": "external" } ], "gene_names_uniprotkb": "Cacng1", "gene_names_refseq": "Cacng1", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma", "protein_names_refseq": "dihydropyridine receptor gamma 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; voltage-dependent calcium channel gamma-1 subunit", "tax_id": 10090, "disease": "malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (mmu:12299)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10799530;11495636;12409298;18192372;33911096;9504716", "class_list": "", "function": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics., [UniProtKB, PubMed, PubMed]; The L-type Ca2+ channel function, but not the sarcoplasmic reticulum Ca2+ release triggering function of the skeletal muscle dihydropyridine receptor, is modulated by the gamma1 subunit, [RefSeq, PubMed]; Thus, we conclude that the alpha(2)delta(1) dihydropyridine receptor subunit is physiologically necessary for sustaining Ca(2+) transients in response to prolonged depolarization or repeated trains of action potentials., [RefSeq, PubMed]; Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0030315 T-tubule;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588 calcium ion transmembrane transport;GO:0070296 sarcoplasmic reticulum calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70578-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01731-1", "uniprot_id": [ { "id": "CD8A_MOUSE", "url": "https://www.uniprot.org/uniprot/P01731", "type": "external" } ], "mass": 27456.0, "length": 247, "protein_name": "T-cell surface glycoprotein CD8 alpha chain", "gene_name": "Cd8a", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_001074579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074579", "type": "external" } ], "gene_names_uniprotkb": "Cd8a; Lyt-2; Lyt2", "gene_names_refseq": "Cd8a; Ly-2; Ly-35; Ly-B; Lyt-2", "protein_names_uniprotkb": "T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2", "protein_names_refseq": "CD8 antigen, alpha chain; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2", "tax_id": 10090, "disease": "erythema multiforme (Disease Ontology:DOID:0050185); immunodeficiency 116 (Disease Ontology:DOID:0061082); COVID-19 (Disease Ontology:DOID:0080600); stomach cancer (Disease Ontology:DOID:10534); brain infarction (Disease Ontology:DOID:3454); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:12525); (R-MMU-198933)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15105501;1673361;18929574;2512251;3267233;3487583;3495785;3927298;3935316;9806638", "class_list": "", "function": "Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0044853 plasma membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P01731-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06796-1", "uniprot_id": [ { "id": "CASK_MOUSE", "url": "https://www.uniprot.org/uniprot/P06796", "type": "external" } ], "mass": 20030.0, "length": 181, "protein_name": "Kappa-casein", "gene_name": "Csn3", "organism": "Mouse", "refseq_name": "kappa-casein isoform a precursor", "refseq_ac": [ { "id": "NP_031812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031812", "type": "external" } ], "gene_names_uniprotkb": "Csn3; Csn10; Csnk", "gene_names_refseq": "CSN10; Csn3; Csnk", "protein_names_uniprotkb": "Kappa-casein", "protein_names_refseq": "kappa-casein isoform a precursor; kappa-casein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12994); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21991377;23613978;31219806;32968199;34203471;36210013;37828378;4042811", "class_list": "", "function": "CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C., [RefSeq, PubMed]; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk., [UniProtKB]; The Csn3 expression is upregulated via all-trans retinoic acid-bound RARalpha. Publication Status: Online-Only, [RefSeq, PubMed]; Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis. Erratum:[Cell Death Differ. 2021 Jul;28(7):2303. doi: 10.1038/s41418-020-00718-3. PMID: 33437040], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1U2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050821 protein stabilization;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06796-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12658-1", "uniprot_id": [ { "id": "CALB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P12658", "type": "external" } ], "mass": 29994.0, "length": 261, "protein_name": "Calbindin", "gene_name": "Calb1", "organism": "Mouse", "refseq_name": "calbindin", "refseq_ac": [ { "id": "NP_033918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033918", "type": "external" } ], "gene_names_uniprotkb": "Calb1", "gene_names_refseq": "Brain-2; CB; Calb-1; Calb1; Calb", "protein_names_uniprotkb": "Calbindin; Calbindin D28; D-28K; PCD-29; Spot 35 protein; Vitamin D-dependent calcium-binding protein, avian-type", "protein_names_refseq": "CalbindinD28K; D-28K; PCD-29; calbindin 1, 28kDa; calbindin D28; calbindin-28K; calbindin-D (28k); calbindin; spot 35 protein; vitamin D-dependent calcium-binding protein, avian-type", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); bilirubin metabolic disorder (Disease Ontology:DOID:2741)", "pathway": " (mmu:12307)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17977745;2465881;3199205;7980557", "class_list": "", "function": "Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545N6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding;GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007626 locomotory behavior;GO:0007614 short-term memory;GO:0048167 regulation of synaptic plasticity;GO:0060041 retina development in camera-type eye;GO:0010996 response to auditory stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15089-1", "uniprot_id": [ { "id": "CBPA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P15089", "type": "external" } ], "mass": 48790.0, "length": 417, "protein_name": "Mast cell carboxypeptidase A", "gene_name": "Cpa3", "organism": "Mouse", "refseq_name": "mast cell carboxypeptidase A preproprotein", "refseq_ac": [ { "id": "NP_031779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031779", "type": "external" } ], "gene_names_uniprotkb": "Cpa3", "gene_names_refseq": "Cpa3; MC-CPA", "protein_names_uniprotkb": "Mast cell carboxypeptidase A; 3.4.17.1; Carboxypeptidase A3; MC-CPA", "protein_names_refseq": "mast cell carboxypeptidase A preproprotein; mast cell carboxypeptidase A", "tax_id": 10090, "disease": "", "pathway": " (mmu:12873); (R-MMU-2022377)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;2584208;28011936;30084848;30779550;34428180;38578780;8746565", "class_list": "", "function": "Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases and preproprotein that is proteolytically processed to generate a mature protein product. This product is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Homozygous knockout mice for this gene exhibit impaired mast cell development. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030133 transport vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0002003 angiotensin maturation;GO:0002002 regulation of angiotensin levels in blood", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P15089-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18111-1", "uniprot_id": [ { "id": "CDX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P18111", "type": "external" } ], "mass": 28436.0, "length": 268, "protein_name": "Homeobox protein CDX-1", "gene_name": "Cdx1", "organism": "Mouse", "refseq_name": "homeobox protein CDX-1", "refseq_ac": [ { "id": "NP_034010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034010", "type": "external" } ], "gene_names_uniprotkb": "Cdx1; Cdx-1", "gene_names_refseq": "Cdx-1; Cdx1; Cdx", "protein_names_uniprotkb": "Homeobox protein CDX-1; Caudal-type homeobox protein 1", "protein_names_refseq": "caudal type homeo box 1; caudal type homeobox transcription factor 1; caudal-type homeobox protein 1; homeobox protein CDX-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12590)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;2905686;7903305", "class_list": "", "function": "Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCF7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18111-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22646-1", "uniprot_id": [ { "id": "CD3E_MOUSE", "url": "https://www.uniprot.org/uniprot/P22646", "type": "external" } ], "mass": 21393.0, "length": 189, "protein_name": "T-cell surface glycoprotein CD3 epsilon chain", "gene_name": "Cd3e", "organism": "Mouse", "refseq_name": "T-cell surface glycoprotein CD3 epsilon chain precursor", "refseq_ac": [ { "id": "NP_031674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031674", "type": "external" } ], "gene_names_uniprotkb": "Cd3e", "gene_names_refseq": "CD3epsilon; CD3; Cd3e; T3e", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain", "protein_names_refseq": "T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain precursor; T-cell surface glycoprotein CD3 epsilon chain", "tax_id": 10090, "disease": "immunodeficiency 18 (Disease Ontology:DOID:0111971); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:12501); (R-MMU-198933); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-389948)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10952314;11439187;19956738;24470497;24899501;25605945;2973066;30084848;30779550;3478717;40592325;9843989", "class_list": "", "function": "Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response (PubMed:9843989, PubMed:10952314, PubMed:19956738, PubMed:24470497, PubMed:24899501, PubMed:40592325). When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:10952314). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:10952314, PubMed:19956738, PubMed:24899501). Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (By similarity). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (By similarity). Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0042101 T cell receptor complex", "go_biological_process": "GO:0046649 lymphocyte activation;GO:0007166 cell surface receptor signaling pathway;GO:0007584 response to nutrient;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22646-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31041-1", "uniprot_id": [ { "id": "CD28_MOUSE", "url": "https://www.uniprot.org/uniprot/P31041", "type": "external" } ], "mass": 25243.0, "length": 218, "protein_name": "T-cell-specific surface glycoprotein CD28", "gene_name": "Cd28", "organism": "Mouse", "refseq_name": "T-cell-specific surface glycoprotein CD28 precursor", "refseq_ac": [ { "id": "NP_031668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031668", "type": "external" } ], "gene_names_uniprotkb": "Cd28", "gene_names_refseq": "Cd28", "protein_names_uniprotkb": "T-cell-specific surface glycoprotein CD28", "protein_names_refseq": "T-cell-specific surface glycoprotein CD28 precursor; T-cell-specific surface glycoprotein CD28", "tax_id": 10090, "disease": "immunodeficiency 123 (Disease Ontology:DOID:0061089); diabetic angiopathy (Disease Ontology:DOID:11713); leukemia (Disease Ontology:DOID:1240); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic fatigue syndrome (Disease Ontology:DOID:8544); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12487); (R-MMU-1257604); (R-MMU-389356); (R-MMU-389357); (R-MMU-389359); (R-MMU-6811558)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;1713603;2157764;25428506;27460989;38830487;7688139", "class_list": "", "function": "Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:7688139). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells., [UniProtKB, UniProtKB, PubMed]; Silencing CD28 attenuated chest blast exposure-induced traumatic brain injury through the PI3K/AKT/NF-kappaB signaling pathway in male mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6GSH7", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0001772 immunological synapse;GO:0098636 protein complex involved in cell adhesion", "go_biological_process": "GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31041-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42082-1", "uniprot_id": [ { "id": "CD86_MOUSE", "url": "https://www.uniprot.org/uniprot/P42082", "type": "external" } ], "mass": 34666.0, "length": 309, "protein_name": "T-lymphocyte activation antigen CD86", "gene_name": "Cd86", "organism": "Mouse", "refseq_name": "T-lymphocyte activation antigen CD86 precursor", "refseq_ac": [ { "id": "NP_062261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062261", "type": "external" } ], "gene_names_uniprotkb": "Cd86", "gene_names_refseq": "B7-2; B7.2; B70; B7; CLS1; Cd28l2; Cd86; ETC-1; Ly-58; Ly58; MB7-2; MB7; TS/A-2", "protein_names_uniprotkb": "T-lymphocyte activation antigen CD86; Activation B7-2 antigen; ETC-1; Early T-cell costimulatory molecule 1", "protein_names_refseq": "T-lymphocyte activation antigen CD86 precursor; T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); corneal disease (Disease Ontology:DOID:10124); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); IgA vasculitis (Disease Ontology:DOID:11123); aplastic anemia (Disease Ontology:DOID:12449); Guillain-Barre syndrome (Disease Ontology:DOID:12842); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); pulmonary hypertension (Disease Ontology:DOID:6432); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12524); (R-MMU-1257604); (R-MMU-389356); (R-MMU-389357); (R-MMU-389359); (R-MMU-389513); (R-MMU-6811558)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "23241883;38349740;7499829;7504059;7513726", "class_list": "", "function": "Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (By similarity). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (By similarity). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (By similarity). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced (PubMed:23241883). Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:7504059, PubMed:7513726)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0031295 T cell costimulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P42082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48298-1", "uniprot_id": [ { "id": "CCL11_MOUSE", "url": "https://www.uniprot.org/uniprot/P48298", "type": "external" } ], "mass": 10893.0, "length": 97, "protein_name": "Eotaxin", "gene_name": "Ccl11", "organism": "Mouse", "refseq_name": "eotaxin precursor", "refseq_ac": [ { "id": "NP_035460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035460", "type": "external" } ], "gene_names_uniprotkb": "Ccl11; Scya11", "gene_names_refseq": "Ccl11; Scya11; eotaxin", "protein_names_uniprotkb": "Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11", "protein_names_refseq": "C-C motif chemokine 11; eosinophil chemotactic protein; eotaxin precursor; small chemokine (C-C motif) ligand 11; small-inducible cytokine A11", "tax_id": 10090, "disease": "nephrotic syndrome type 1 (Disease Ontology:DOID:0080390); COVID-19 (Disease Ontology:DOID:0080600); pleurisy (Disease Ontology:DOID:10247); viral pneumonia (Disease Ontology:DOID:10533); interstitial nephritis (Disease Ontology:DOID:1063); allergic conjunctivitis (Disease Ontology:DOID:11204); mucopolysaccharidosis IV (Disease Ontology:DOID:12804); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); bronchiolitis (Disease Ontology:DOID:2942); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); cataract (Disease Ontology:DOID:83); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20292); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10438970;15647285;30084848;34428180;34830041;35614068;36651177;36982260;7568052;8574847;9169149", "class_list": "", "function": "Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed:7568052, PubMed:8574847). Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway., [UniProtKB, UniProtKB, PubMed, PubMed]; Regulatory role and translational potential of CCL11 in liver fibrosis., [RefSeq, PubMed]; Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0046983 protein dimerization activity;GO:0016004 phospholipase activator activity;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007015 actin filament organization;GO:0007611 learning or memory;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P48298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50283-1", "uniprot_id": [ { "id": "CD7_MOUSE", "url": "https://www.uniprot.org/uniprot/P50283", "type": "external" } ], "mass": 23153.0, "length": 210, "protein_name": "T-cell antigen CD7", "gene_name": "Cd7", "organism": "Mouse", "refseq_name": "T-cell antigen CD7 precursor", "refseq_ac": [ { "id": "NP_033984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033984", "type": "external" } ], "gene_names_uniprotkb": "Cd7", "gene_names_refseq": "Cd7", "protein_names_uniprotkb": "T-cell antigen CD7", "protein_names_refseq": "T-cell antigen CD7 precursor; T-cell antigen CD7", "tax_id": 10090, "disease": "", "pathway": " (mmu:12516)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10075985;10652336;7509775;7528728;7678579;9637484", "class_list": "", "function": "Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1. In turn, mediates the production of cytokines such as IL-2. On resting NK-cells, CD7 activation results in a significant induction of gamma-interferon levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0048873 homeostasis of number of cells within a tissue;GO:0002250 adaptive immune response;GO:0002726 positive regulation of T cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50283-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55097-1", "uniprot_id": [ { "id": "CATK_MOUSE", "url": "https://www.uniprot.org/uniprot/P55097", "type": "external" } ], "mass": 36889.0, "length": 329, "protein_name": "Cathepsin K", "gene_name": "Ctsk", "organism": "Mouse", "refseq_name": "cathepsin K preproprotein", "refseq_ac": [ { "id": "NP_031828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031828", "type": "external" } ], "gene_names_uniprotkb": "Ctsk", "gene_names_refseq": "Ctsk; MMS10-Q; Ms10q; catK", "protein_names_uniprotkb": "Cathepsin K; 3.4.22.38", "protein_names_refseq": "Cat K; cathepsin K preproprotein", "tax_id": 10090, "disease": "pycnodysostosis (Disease Ontology:DOID:0080038); otitis media (Disease Ontology:DOID:10754); intracranial aneurysm (Disease Ontology:DOID:10941)", "pathway": " (mmu:13038); (R-MMU-1442490); (R-MMU-1474228); (R-MMU-1592389); (R-MMU-1679131); (R-MMU-2132295); (R-MMU-8939242)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10372556;12782676;25428506;34428180;8814310", "class_list": "", "function": "Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676)., [UniProtKB, PubMed]; This gene encodes a member of the cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88718", "ec_number_list": [ { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.22.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.41", "type": "external" } ], "go_molecular_function": "GO:0005518 collagen binding;GO:0008233 peptidase activity;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0045453 bone resorption;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P55097-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70190-1", "uniprot_id": [ { "id": "CAZA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70190", "type": "external" } ], "mass": 34952.0, "length": 299, "protein_name": "F-actin-capping protein subunit alpha-3", "gene_name": "Capza3", "organism": "Mouse", "refseq_name": "F-actin-capping protein subunit alpha-3", "refseq_ac": [ { "id": "NP_031631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031631", "type": "external" } ], "gene_names_uniprotkb": "Capza3; Cappa3; Gsg3", "gene_names_refseq": "510-4; Cappa3; Capza3; Gsg3; Tex8; repro32", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-3; CapZ alpha-3; Germ cell-specific protein 3", "protein_names_refseq": "F-actin-capping protein subunit alpha-3; capZ alpha-3; capping protein (actin filament) muscle Z-line, alpha 3; capping protein alpha 3; cp alpha3; germ cell-specific protein 3", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:12344)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10524250;19341723;20458735;7957958", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid., [UniProtKB]; These observations strongly suggest the missense mutation in Capza3 is responsible for the mutant phenotype of repro32/repro32 sperm and regulation of F-actin dynamics, [RefSeq, PubMed]; To understand actin-mediated change in protein localization during acrosome reaction, distribution of CAPZA3 was analyzed; like IZUMO1, CAPZA3 shows dynamic pattern of localization; movements follow different temporal pattern than changes seen with IZUMO1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4N3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0061827 sperm head;GO:0016020 membrane;GO:0008290 F-actin capping protein complex;GO:0001669 acrosomal vesicle;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0007028 cytoplasm organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B48-1", "uniprot_id": [ { "id": "ITPI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B48", "type": "external" } ], "mass": 115605.0, "length": 1034, "protein_name": "Protein ITPRID1", "gene_name": "Itprid1", "organism": "Mouse", "refseq_name": "protein ITPRID1 isoform 1", "refseq_ac": [ { "id": "NP_001075134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075134", "type": "external" } ], "gene_names_uniprotkb": "Itprid1; Ccdc129", "gene_names_refseq": "Ccdc129; D530004J12Rik; Gm458; Itprid1", "protein_names_uniprotkb": "Protein ITPRID1; Coiled-coil domain-containing protein 129; ITPR-interacting domain-containing protein 1", "protein_names_refseq": "ITPR-interacting domain-containing protein 1; coiled-coil domain containing 129; coiled-coil domain-containing protein 129; protein ITPRID1 isoform 1; protein ITPRID1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232016)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25428506;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUH5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q14B48-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZA2-1", "uniprot_id": [ { "id": "CDKL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZA2", "type": "external" } ], "mass": 39446.0, "length": 342, "protein_name": "Cyclin-dependent kinase-like 4", "gene_name": "Cdkl4", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase-like 4", "refseq_ac": [ { "id": "NP_001028615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028615", "type": "external" } ], "gene_names_uniprotkb": "Cdkl4; Gm942", "gene_names_refseq": "Cdkl4; Gm942", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 4; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase-like 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:381113)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSS7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TZA2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UYG1-1", "uniprot_id": [ { "id": "CC160_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UYG1", "type": "external" } ], "mass": 37398.0, "length": 323, "protein_name": "Coiled-coil domain-containing protein 160", "gene_name": "Ccdc160", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 160", "refseq_ac": [ { "id": "NP_001029231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029231", "type": "external" } ], "gene_names_uniprotkb": "Ccdc160", "gene_names_refseq": "6330534C20Rik; Ccdc160", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 160", "protein_names_refseq": "coiled-coil domain-containing protein 160", "tax_id": 10090, "disease": "", "pathway": " (mmu:434778)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UYG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V036-1", "uniprot_id": [ { "id": "CCD27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V036", "type": "external" } ], "mass": 73651.0, "length": 639, "protein_name": "Coiled-coil domain-containing protein 27", "gene_name": "Ccdc27", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 27", "refseq_ac": [ { "id": "NP_001028627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028627", "type": "external" } ], "gene_names_uniprotkb": "Ccdc27; Gm1035", "gene_names_refseq": "Ccdc27; Gm1035", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 27", "protein_names_refseq": "coiled-coil domain-containing protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:381580)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V036-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V037-1", "uniprot_id": [ { "id": "CF163_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V037", "type": "external" } ], "mass": 38548.0, "length": 328, "protein_name": "Uncharacterized protein C6orf163 homolog", "gene_name": "Gm136", "organism": "Mouse", "refseq_name": "uncharacterized protein C6orf163 homolog", "refseq_ac": [ { "id": "NP_001028427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028427", "type": "external" } ], "gene_names_uniprotkb": "Gm136", "gene_names_refseq": "Gm136", "protein_names_uniprotkb": "Uncharacterized protein C6orf163 homolog", "protein_names_refseq": "uncharacterized protein C6orf163 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:214568)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V037-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V2D2-1", "uniprot_id": [ { "id": "CE046_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V2D2", "type": "external" } ], "mass": 10038.0, "length": 93, "protein_name": "Uncharacterized protein C5orf46 homolog", "gene_name": "Gm94", "organism": "Mouse", "refseq_name": "uncharacterized protein C5orf46 homolog precursor", "refseq_ac": [ { "id": "NP_001028452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028452", "type": "external" } ], "gene_names_uniprotkb": "Gm94", "gene_names_refseq": "Gm94", "protein_names_uniprotkb": "Uncharacterized protein C5orf46 homolog", "protein_names_refseq": "uncharacterized protein C5orf46 homolog precursor; uncharacterized protein C5orf46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:225443)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V2D2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCY3-1", "uniprot_id": [ { "id": "CB5D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCY3", "type": "external" } ], "mass": 26719.0, "length": 228, "protein_name": "Cytochrome b5 domain-containing protein 1", "gene_name": "Cyb5d1", "organism": "Mouse", "refseq_name": "cytochrome b5 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001038990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038990", "type": "external" } ], "gene_names_uniprotkb": "Cyb5d1; Gm740", "gene_names_refseq": "Cyb5d1; Gm740", "protein_names_uniprotkb": "Cytochrome b5 domain-containing protein 1", "protein_names_refseq": "cytochrome b5 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:327951)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;25428506;30084848;30779550", "class_list": "", "function": "Cyb5d1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCY4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0003356 regulation of cilium beat frequency", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5NCY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPV6-1", "uniprot_id": [ { "id": "CMIP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPV6", "type": "external" } ], "mass": 26410.0, "length": 233, "protein_name": "Ciliary microtubule inner protein 6", "gene_name": "Cimip6", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 6", "refseq_ac": [ { "id": "NP_001093864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093864", "type": "external" } ], "gene_names_uniprotkb": "Cimip6; 4930505A04Rik", "gene_names_refseq": "4930505A04Rik; Cimip6", "protein_names_uniprotkb": "Ciliary microtubule inner protein 6", "protein_names_refseq": "ciliary microtubule inner protein 6; uncharacterized protein C2orf73 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75087)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810N4;Q9D580", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SPV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPX1-1", "uniprot_id": [ { "id": "CC157_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPX1", "type": "external" } ], "mass": 79795.0, "length": 718, "protein_name": "Coiled-coil domain-containing protein 157", "gene_name": "Ccdc157", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 157 isoform 1", "refseq_ac": [ { "id": "NP_001158092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158092", "type": "external" } ], "gene_names_uniprotkb": "Ccdc157; Kiaa1656", "gene_names_refseq": "4930562D19Rik; Ccdc157; mKIAA1656", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 157", "protein_names_refseq": "coiled-coil domain-containing protein 157 isoform 1; coiled-coil domain-containing protein 157", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (mmu:216516)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;38509755", "class_list": "", "function": "4930562D19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P531;Q3V0G5;Q5DTW1;Q8C5Y5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SPX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U465-1", "uniprot_id": [ { "id": "CC125_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U465", "type": "external" } ], "mass": 56655.0, "length": 500, "protein_name": "Coiled-coil domain-containing protein 125", "gene_name": "Ccdc125", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 125 isoform B", "refseq_ac": [ { "id": "NP_001161858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161858", "type": "external" } ], "gene_names_uniprotkb": "Ccdc125; Kenae", "gene_names_refseq": "5830436D01Rik; Ccdc125", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 125", "protein_names_refseq": "coiled-coil domain-containing protein 125 isoform B; coiled-coil domain-containing protein 125", "tax_id": 10090, "disease": "", "pathway": " (mmu:76041)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18299400;19787194;21750661;30779550", "class_list": "", "function": "May be involved in the regulation of cell migration., [UniProtKB]; These results suggest that the novel gene, Kenae/CCDC125, acts as a regulator of cell motility through RhoA, Rac1 and cdc42., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPT5;Q8CEN7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0090630 activation of GTPase activity;GO:0035024 negative regulation of Rho protein signal transduction;GO:2000146 negative regulation of cell motility;GO:2000145 regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U465-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60755-1", "uniprot_id": [ { "id": "CALCR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60755", "type": "external" } ], "mass": 62469.0, "length": 533, "protein_name": "Calcitonin receptor", "gene_name": "Calcr", "organism": "Mouse", "refseq_name": "calcitonin receptor isoform 1a precursor", "refseq_ac": [ { "id": "NP_001036190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036190", "type": "external" } ], "gene_names_uniprotkb": "Calcr", "gene_names_refseq": "Calcr; Clr; Ct-r", "protein_names_uniprotkb": "Calcitonin receptor; CT-R", "protein_names_refseq": "calcitonin receptor isoform 1a precursor", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:12311); (R-MMU-418555); (R-MMU-419812)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;7988453", "class_list": "", "function": "G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "F6X7J4;Q3UUL9;Q8CAB0", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0004948 calcitonin receptor activity;GO:0032841 calcitonin binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0097643 amylin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60755-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62447-1", "uniprot_id": [ { "id": "CCNC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62447", "type": "external" } ], "mass": 33241.0, "length": 283, "protein_name": "Cyclin-C", "gene_name": "Ccnc", "organism": "Mouse", "refseq_name": "cyclin-C isoform 2", "refseq_ac": [ { "id": "NP_001277351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277351", "type": "external" } ], "gene_names_uniprotkb": "Ccnc", "gene_names_refseq": "CG1C; Ccnc", "protein_names_uniprotkb": "Cyclin-C", "protein_names_refseq": "cyclin-C isoform 2; dJ199J3.4 (cyclin C)", "tax_id": 10090, "disease": "", "pathway": " (mmu:51813); (R-MMU-2173796)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "31219806;32248761;32934007", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity)., [UniProtKB]; Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics., [RefSeq, PubMed]; The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P542;Q5XKQ9;Q9WUZ4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090209 negative regulation of triglyceride metabolic process;GO:0016567 protein ubiquitination;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62447-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5U8-1", "uniprot_id": [ { "id": "CC148_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5U8", "type": "external" } ], "mass": 63396.0, "length": 527, "protein_name": "Coiled-coil domain-containing protein 148", "gene_name": "Ccdc148", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 148 isoform 2", "refseq_ac": [ { "id": "NP_001001178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001178", "type": "external" } ], "gene_names_uniprotkb": "Ccdc148", "gene_names_refseq": "5830402J09; Ccdc148; Gm38473", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 148", "protein_names_refseq": "coiled-coil domain-containing protein 148 isoform 2; coiled-coil domain-containing protein 148", "tax_id": 10090, "disease": "", "pathway": " (mmu:227933)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21297076;21750661", "class_list": "", "function": "Ccdc148 is associated with acute lung injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APN1;Q8CDB5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P5U8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8K8-1", "uniprot_id": [ { "id": "CBPA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8K8", "type": "external" } ], "mass": 47339.0, "length": 420, "protein_name": "Carboxypeptidase A4", "gene_name": "Cpa4", "organism": "Mouse", "refseq_name": "carboxypeptidase A4 preproprotein", "refseq_ac": [ { "id": "NP_082202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082202", "type": "external" } ], "gene_names_uniprotkb": "Cpa4", "gene_names_refseq": "1110019K20Rik; Cpa4", "protein_names_uniprotkb": "Carboxypeptidase A4; 3.4.17.-", "protein_names_refseq": "carboxypeptidase A4 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71791)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20385563;28011936;32347291", "class_list": "", "function": "CPA4 functions in neuropeptide processing and regulation in the extracellular environment, [RefSeq, PubMed]; Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling., [RefSeq, PubMed]; Metalloprotease that cleaves hydrophobic C-terminal residues with a preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (By similarity). May function in peptide hormone and/or neuropeptide catabolism (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases that could be involved in the histone hyperacetylation pathway. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMK6;Q9CTE6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0042447 hormone catabolic process;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P8K8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAC4-1", "uniprot_id": [ { "id": "PCARE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAC4", "type": "external" } ], "mass": 139298.0, "length": 1279, "protein_name": "Photoreceptor cilium actin regulator", "gene_name": "Pcare", "organism": "Mouse", "refseq_name": "photoreceptor cilium actin regulator isoform 1", "refseq_ac": [ { "id": "NP_666194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666194", "type": "external" } ], "gene_names_uniprotkb": "Pcare", "gene_names_refseq": "Pcare", "protein_names_uniprotkb": "Photoreceptor cilium actin regulator", "protein_names_refseq": "photoreceptor cilium actin regulator isoform 1; uncharacterized protein C2orf71 homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 54 (Disease Ontology:DOID:0110364)", "pathway": " (mmu:225004)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20398884;25616964;32312818", "class_list": "", "function": "Our work suggests that PCARE is an actin-associated protein that interacts with WASF3 to regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment disk formation., [RefSeq, PubMed]; Plays an essential role for normal photoreceptor cell maintenance and vision., [UniProtKB, PubMed]; RNAseq analysis of ocular gene expression in BC(-/-) mice revealed clues to the causes of the progressive retinal degenerations., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXR7;Q8R0C5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0035845 photoreceptor cell outer segment organization;GO:0050908 detection of light stimulus involved in visual perception;GO:1903546 protein localization to photoreceptor outer segment", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PAC4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHN1-1", "uniprot_id": [ { "id": "CCD57_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHN1", "type": "external" } ], "mass": 116194.0, "length": 1016, "protein_name": "Coiled-coil domain-containing protein 57", "gene_name": "Ccdc57", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 57 isoform 1", "refseq_ac": [ { "id": "NP_082021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082021", "type": "external" } ], "gene_names_uniprotkb": "Ccdc57", "gene_names_refseq": "4933434G05Rik; Ccdc57", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 57", "protein_names_refseq": "coiled-coil domain-containing protein 57 isoform 1; coiled-coil domain-containing protein 57", "tax_id": 10090, "disease": "", "pathway": " (mmu:71276)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22872234;25428506;30084848;32402286", "class_list": "", "function": "Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis (PubMed:32402286). Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0045931 positive regulation of mitotic cell cycle;GO:0000086 G2/M transition of mitotic cell cycle;GO:0060271 cilium assembly;GO:0007020 microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PHN1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RUT8-3", "uniprot_id": [ { "id": "CC154_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RUT8", "type": "external" } ], "mass": 76128.0, "length": 664, "protein_name": "Coiled-coil domain-containing protein 154", "gene_name": "Ccdc154", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 154", "refseq_ac": [ { "id": "NP_001073398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073398", "type": "external" } ], "gene_names_uniprotkb": "Ccdc154; Gm317", "gene_names_refseq": "Ccdc154; Ccdc157; Gm317; ntl", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 154; Golgin-160-like protein", "protein_names_refseq": "Grailexp predicted; coiled-coil domain-containing protein 154; golgin-160-like protein", "tax_id": 10090, "disease": "autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942)", "pathway": " (mmu:207209)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22895184", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G9JV17;Q3V0K0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome", "go_biological_process": "GO:0046849 bone remodeling;GO:0045453 bone resorption;GO:0007605 sensory perception of sound;GO:0042475 odontogenesis of dentin-containing tooth;GO:0035630 bone mineralization involved in bone maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6RUT8-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78PG9-1", "uniprot_id": [ { "id": "CCD25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78PG9", "type": "external" } ], "mass": 24480.0, "length": 208, "protein_name": "Coiled-coil domain-containing protein 25", "gene_name": "Ccdc25", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 25", "refseq_ac": [ { "id": "NP_666056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666056", "type": "external" } ], "gene_names_uniprotkb": "Ccdc25", "gene_names_refseq": "2610528H13Rik; Ccdc25; NSrp70", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 25", "protein_names_refseq": "coiled-coil domain-containing protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:67179)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;21183079;25428506;27802388;30084848;30779550;32528174;34428180;37092777", "class_list": "", "function": "Ccdc25 regulates neurogenesis during the brain development., [RefSeq, PubMed]; Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (By similarity). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (By similarity). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSQ8;Q9CUF8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:2000147 positive regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q78PG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHG3-1", "uniprot_id": [ { "id": "CC50B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHG3", "type": "external" } ], "mass": 39218.0, "length": 353, "protein_name": "Cell cycle control protein 50B", "gene_name": "Tmem30b", "organism": "Mouse", "refseq_name": "cell cycle control protein 50B", "refseq_ac": [ { "id": "NP_848830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848830", "type": "external" } ], "gene_names_uniprotkb": "Tmem30b; Cdc50b", "gene_names_refseq": "9130011B11Rik; Cdc50b; Tmem30b", "protein_names_uniprotkb": "Cell cycle control protein 50B; Transmembrane protein 30B", "protein_names_refseq": "cell cycle control protein 50B; transmembrane protein 30B", "tax_id": 10090, "disease": "", "pathway": " (mmu:238257)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "39384739", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane (By similarity)., [UniProtKB]; CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:1990531 phospholipid-translocating ATPase complex", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0070863 positive regulation of protein exit from endoplasmic reticulum;GO:0015917 aminophospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHG3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BS39-1", "uniprot_id": [ { "id": "CCD32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BS39", "type": "external" } ], "mass": 19928.0, "length": 179, "protein_name": "Coiled-coil domain-containing protein 32", "gene_name": "Ccdc32", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccdc32; Gm631", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 32", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32307552", "class_list": "", "function": "Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis (PubMed:32307552). Required for proper cephalic and left/right axis development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U667;Q7TPZ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005905 clathrin-coated pit", "go_biological_process": "GO:2000369 regulation of clathrin-dependent endocytosis;GO:0044782 cilium organization;GO:0060322 head development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BS39-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVF4-1", "uniprot_id": [ { "id": "CCD30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVF4", "type": "external" } ], "mass": 76048.0, "length": 654, "protein_name": "Coiled-coil domain-containing protein 30", "gene_name": "Ccdc30", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 30 isoform b", "refseq_ac": [ { "id": "NP_001257364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257364", "type": "external" } ], "gene_names_uniprotkb": "Ccdc30; Pfdn6l", "gene_names_refseq": "1700001O02Rik; 1700041C02Rik; 1700111D19Rik; 4930445I03Rik; Ccdc30", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 30; Prefoldin subunit 6-like protein", "protein_names_refseq": "coiled-coil domain-containing protein 30 isoform b; coiled-coil domain-containing protein 30; prefoldin subunit 6-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73332)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14CD0;Q3TR07;Q9D9N6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVF4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAI1-1", "uniprot_id": [ { "id": "CC142_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAI1", "type": "external" } ], "mass": 79817.0, "length": 738, "protein_name": "Coiled-coil domain-containing protein 142", "gene_name": "Ccdc142", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 142", "refseq_ac": [ { "id": "NP_001074735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074735", "type": "external" } ], "gene_names_uniprotkb": "Ccdc142", "gene_names_refseq": "A230058J24Rik; Ccdc142", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 142", "protein_names_refseq": "coiled-coil domain-containing protein 142", "tax_id": 10090, "disease": "", "pathway": " (mmu:243510)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CAI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDV0-1", "uniprot_id": [ { "id": "CC178_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDV0", "type": "external" } ], "mass": 103041.0, "length": 866, "protein_name": "Coiled-coil domain-containing protein 178", "gene_name": "Ccdc178", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 178", "refseq_ac": [ { "id": "NP_081892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081892", "type": "external" } ], "gene_names_uniprotkb": "Ccdc178", "gene_names_refseq": "4921528I01Rik; Ccdc178", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 178", "protein_names_refseq": "coiled-coil domain-containing protein 178", "tax_id": 10090, "disease": "", "pathway": " (mmu:70950)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39157459", "class_list": "", "function": "Plays a crucial role in head shaping and sperm flagellum formation, and is vital for male fertility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN78", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007286 spermatid development;GO:1905198 manchette assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CDV0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2J4-1", "uniprot_id": [ { "id": "CCD14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2J4", "type": "external" } ], "mass": 102630.0, "length": 934, "protein_name": "Coiled-coil domain-containing protein 14", "gene_name": "Ccdc14", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 14", "refseq_ac": [ { "id": "NP_766412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766412", "type": "external" } ], "gene_names_uniprotkb": "Ccdc14", "gene_names_refseq": "Ccdc14; G630039H03Rik", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 14", "protein_names_refseq": "coiled-coil domain-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:239839)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22872234;25428506;34418053", "class_list": "", "function": "Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ89", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0071539 protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K2J4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K354-1", "uniprot_id": [ { "id": "CBR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K354", "type": "external" } ], "mass": 30953.0, "length": 277, "protein_name": "Carbonyl reductase [NADPH] 3", "gene_name": "Cbr3", "organism": "Mouse", "refseq_name": "carbonyl reductase [NADPH] 3", "refseq_ac": [ { "id": "NP_766635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766635", "type": "external" } ], "gene_names_uniprotkb": "Cbr3", "gene_names_refseq": "1110001J05Rik; Cbr3", "protein_names_uniprotkb": "Carbonyl reductase [NADPH] 3; 1.1.1.184; 1.6.5.10; NADPH-dependent carbonyl reductase 3; Quinone reductase CBR3", "protein_names_refseq": "NADPH-dependent carbonyl reductase 3; carbonyl reductase [NADPH] 3; quinone reductase CBR3", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:109857); (R-MMU-211945)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25153642;28135057;35820727", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, as well as on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" } ], "go_molecular_function": "GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding;GO:0004090 carbonyl reductase (NADPH) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050890 cognition;GO:0042376 phylloquinone catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K354-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4F0-1", "uniprot_id": [ { "id": "CD226_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4F0", "type": "external" } ], "mass": 38063.0, "length": 333, "protein_name": "CD226 antigen", "gene_name": "Cd226", "organism": "Mouse", "refseq_name": "CD226 antigen isoform a precursor", "refseq_ac": [ { "id": "NP_848802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848802", "type": "external" } ], "gene_names_uniprotkb": "Cd226; Pta1", "gene_names_refseq": "Cd226; DNAM-1; DNAM1; Pta1; TLiSA1", "protein_names_uniprotkb": "CD226 antigen; Platelet and T-cell activation antigen 1", "protein_names_refseq": "CD226 antigen isoform a precursor; platelet and T cell activation antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225825); (R-MMU-198933)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15752754;16034094;16249389;19029379;21750661;24658051;26552706;30084848;30591568;37392373;37580402;37864795;38325579", "class_list": "", "function": "CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice., [RefSeq, PubMed]; CD226 is a costimulatory molecule that plays an important role in activation and effector functions of T helper type 1 (Th1) cells., [RefSeq, PubMed]; CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions., [RefSeq, PubMed]; Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:19029379, PubMed:24658051, PubMed:26552706). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model., [RefSeq, PubMed]; DNAM-1 ligands stimulate innate immunity by in dendritic and natural killer cells, which efficiently prime cell-mediated tumor-specific immunity., [RefSeq, PubMed]; Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer., [RefSeq, PubMed]; We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0032729 positive regulation of type II interferon production;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K4F0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2S8-1", "uniprot_id": [ { "id": "CD177_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2S8", "type": "external" } ], "mass": 87091.0, "length": 817, "protein_name": "CD177 antigen", "gene_name": "Cd177", "organism": "Mouse", "refseq_name": "CD177 antigen isoform 1 precursor", "refseq_ac": [ { "id": "NP_081138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081138", "type": "external" } ], "gene_names_uniprotkb": "Cd177", "gene_names_refseq": "1190003K14Rik; Cd177; Pdp3", "protein_names_uniprotkb": "CD177 antigen", "protein_names_refseq": "CD177 antigen isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68891); (R-MMU-202733); (R-MMU-6798695); (R-MMU-9769739)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "25359465;27802388;29187734;30084848;38226808;38871062;39627609", "class_list": "", "function": "CD177 on neutrophils engages stress-related behavioral changes in male mice., [RefSeq, PubMed]; Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils., [RefSeq, PubMed]; In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production (By similarity). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (By similarity). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (By similarity). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:25359465). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (By similarity). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0070821 tertiary granule membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030100 regulation of endocytosis;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R2S8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW4-1", "uniprot_id": [ { "id": "CCG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHW4", "type": "external" } ], "mass": 30894.0, "length": 275, "protein_name": "Voltage-dependent calcium channel gamma-5 subunit", "gene_name": "Cacng5", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-5 subunit", "refseq_ac": [ { "id": "NP_001186230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186230", "type": "external" } ], "gene_names_uniprotkb": "Cacng5", "gene_names_refseq": "Cacng5", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; TARP gamma-5; Transmembrane AMPAR regulatory protein gamma-5", "protein_names_refseq": "TARP gamma-5; neuronal voltage-gated calcium channel gamma-5 subunit; transmembrane AMPAR regulatory protein gamma-5; voltage-dependent calcium channel gamma-5 subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:140723)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11738816;18817736", "class_list": "", "function": "Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY3-1", "uniprot_id": [ { "id": "CDCA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY3", "type": "external" } ], "mass": 28991.0, "length": 264, "protein_name": "Sororin", "gene_name": "Cdca5", "organism": "Mouse", "refseq_name": "sororin", "refseq_ac": [ { "id": "NP_080686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080686", "type": "external" } ], "gene_names_uniprotkb": "Cdca5", "gene_names_refseq": "2610036L13Rik; Cdca5", "protein_names_uniprotkb": "Sororin; Cell division cycle-associated protein 5", "protein_names_refseq": "cell division cycle-associated protein 5; sororin p35; sororin", "tax_id": 10090, "disease": "", "pathway": " (mmu:67849); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2500257)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21111234;28050734", "class_list": "", "function": "Regulator of sister chromatid cohesion in mitosis, stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair., [UniProtKB, PubMed]; Results indicate that Sororin regulation during meiosis is distinct from its regulation in mitotic cells and may suggest that it interacts with a distinctly different partner to ensure proper chromosome dynamics in meiosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q78HI6", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPY3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQD4-1", "uniprot_id": [ { "id": "CH1B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQD4", "type": "external" } ], "mass": 22161.0, "length": 199, "protein_name": "Charged multivesicular body protein 1B2", "gene_name": "Chmp1b2", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 1B2", "refseq_ac": [ { "id": "NP_080197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080197", "type": "external" } ], "gene_names_uniprotkb": "Chmp1b2", "gene_names_refseq": "2610002M06Rik; 8430408J07Rik; Chmp1b2", "protein_names_uniprotkb": "Charged multivesicular body protein 1B2; CHMP1b-2; Chromatin-modifying protein 1b-2", "protein_names_refseq": "CHMP1b-2; charged multivesicular body protein 1B2; charged multivesicular body protein 1b-2; chromatin-modifying protein 1b-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67028)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;26495903;30084848;30779550", "class_list": "", "function": "Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATX3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0061763 multivesicular body-lysosome fusion;GO:0015031 protein transport;GO:0051301 cell division;GO:0045324 late endosome to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR29-1", "uniprot_id": [ { "id": "CCD43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR29", "type": "external" } ], "mass": 25049.0, "length": 222, "protein_name": "Coiled-coil domain-containing protein 43", "gene_name": "Ccdc43", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 43", "refseq_ac": [ { "id": "NP_080194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080194", "type": "external" } ], "gene_names_uniprotkb": "Ccdc43; D11Ertd707e", "gene_names_refseq": "2610001E01Rik; Ccdc43; D11Ertd707e", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 43", "protein_names_refseq": "coiled-coil domain-containing protein 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:52715)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDT2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXL7-1", "uniprot_id": [ { "id": "SNORC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXL7", "type": "external" } ], "mass": 12175.0, "length": 121, "protein_name": "Protein SNORC", "gene_name": "Snorc", "organism": "Mouse", "refseq_name": "protein SNORC isoform 1 precursor", "refseq_ac": [ { "id": "NP_082749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082749", "type": "external" } ], "gene_names_uniprotkb": "Snorc", "gene_names_refseq": "3110079O15Rik; Snorc", "protein_names_uniprotkb": "Protein SNORC; Secondary ossification center-associated regulator of chondrocyte maturation protein", "protein_names_refseq": "protein SNORC isoform 1 precursor; protein SNORC transcript; secondary ossification center-associated regulator of chondrocyte maturation protein; uncharacterized protein C2orf82 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73234)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21624478;28323137", "class_list": "", "function": "A novel cartilage-specific molecule, Snorc, was identified that may have functions associated with development and maintenance of chondrocyte phenotype, [RefSeq, PubMed]; Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2., [UniProtKB, PubMed]; Snorc is expressed postnatally in knee epiphyses especially by prehypertrophic chondrocytes delineating the cartilage canals and secondary ossification center. Snorc core protein binds to FGF2 and inhibits FGF2 dependent cell growth of C3H101/2 cells. In Snorc deficient mice, Snorc deficiency caused defects in secondary ossification and growth plate maturation associated with increased Ihh and reduced MMP13 expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q08EF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1C2-1", "uniprot_id": [ { "id": "CBY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1C2", "type": "external" } ], "mass": 14535.0, "length": 127, "protein_name": "Protein chibby homolog 1", "gene_name": "Cby1", "organism": "Mouse", "refseq_name": "protein chibby homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_082910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082910", "type": "external" } ], "gene_names_uniprotkb": "Cby1; Cby; Pgea1", "gene_names_refseq": "1110014P06Rik; CBY; Cby1; PGEA14; Pgea1; arb1", "protein_names_uniprotkb": "Protein chibby homolog 1; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1", "protein_names_refseq": "PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; PKD2 interactor, golgi and endoplasmic reticulum associated 1; cytosolic leucine-rich protein; protein chibby homolog 1 isoform 1; protein chibby homolog 1", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:73739); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17261658;17403895;18299400;21952136;25428506;27528616;30084848;30779550;34428180;34446743;35820727", "class_list": "", "function": "FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (By similarity). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (By similarity). Promotes adipocyte and cardiomyocyte differentiation (PubMed:17261658, PubMed:17403895)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0060271 cilium assembly;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D1C2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1I2-1", "uniprot_id": [ { "id": "CAR19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1I2", "type": "external" } ], "mass": 20936.0, "length": 183, "protein_name": "Caspase recruitment domain-containing protein 19", "gene_name": "Card19", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 19 isoform 1", "refseq_ac": [ { "id": "NP_081014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081014", "type": "external" } ], "gene_names_uniprotkb": "Card19", "gene_names_refseq": "1110007C09Rik; Bincard; Card19", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 19; Bcl10-interacting CARD protein; BinCARD", "protein_names_refseq": "Bcl10-interacting protein with Card; bcl10-interacting CARD protein; caspase recruitment domain-containing protein 19 isoform 1; caspase recruitment domain-containing protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:68480)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;35406738;36961449", "class_list": "", "function": "CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology. Publication Status: Online-Only, [RefSeq, PubMed]; CARD19, a Novel Regulator of the TAK1/NF-kappaB Pathway in Self-Reactive B Cells., [RefSeq, PubMed]; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3Y9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D727-1", "uniprot_id": [ { "id": "PEX39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D727", "type": "external" } ], "mass": 12013.0, "length": 114, "protein_name": "Peroxisomal biogenesis factor 39", "gene_name": "Pex39", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pex39", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 39; Peroxin-39; Protein C6orf226 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:67101)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;28135057;32782141", "class_list": "", "function": "Cytosolic peroxin that promotes the peroxisomal import of proteins containing a type-2 peroxisomal targeting signal (PTS2) by binding to PEX7 and stabilizing its interaction with PTS2-containing cargo. PEX39 subsequently transfers the PEX7-cargo complex to PEX13 at the peroxisomal membrane, enabling PEX7 to bind PEX13 and facilitating translocation of PTS2-containing proteins into the peroxisome. Both PEX39 and PEX13 contain a conserved KPWE motif, which enables competitive binding to PEX7 and ensures efficient handover of the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1N0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D727-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9Q6-1", "uniprot_id": [ { "id": "CALR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9Q6", "type": "external" } ], "mass": 44232.0, "length": 380, "protein_name": "Calreticulin-3", "gene_name": "Calr3", "organism": "Mouse", "refseq_name": "calreticulin-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_082776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082776", "type": "external" } ], "gene_names_uniprotkb": "Calr3; Crt2", "gene_names_refseq": "1700031L01Rik; 6330586I20Rik; Calr3; Crt2; cspn", "protein_names_uniprotkb": "Calreticulin-3; Calreticulin-2; Calsperin", "protein_names_refseq": "calreticulin-2; calreticulin-3 isoform 1 precursor; calspeculin; calsperin", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:73316)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12384296;16931514;21131354;21540332;37828378", "class_list": "glycogene", "function": "CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility., [UniProtKB, PubMed]; Calsperin is a testis-specific chaperone required for sperm fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E827", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D9Q6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAL3-1", "uniprot_id": [ { "id": "CCD54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAL3", "type": "external" } ], "mass": 37518.0, "length": 329, "protein_name": "Coiled-coil domain-containing protein 54", "gene_name": "Ccdc54", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 54", "refseq_ac": [ { "id": "NP_081322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081322", "type": "external" } ], "gene_names_uniprotkb": "Ccdc54", "gene_names_refseq": "1700007N18Rik; Ccdc54; NYD-SP17", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 54", "protein_names_refseq": "coiled-coil domain-containing protein 54; testes development-related NYD-SP17", "tax_id": 10090, "disease": "", "pathway": " (mmu:69339)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAS2-1", "uniprot_id": [ { "id": "CMI2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAS2", "type": "external" } ], "mass": 23070.0, "length": 200, "protein_name": "Ciliary microtubule inner protein 2C", "gene_name": "Cimip2c", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 2C isoform 1", "refseq_ac": [ { "id": "NP_083561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083561", "type": "external" } ], "gene_names_uniprotkb": "Cimip2c; 1700001C02Rik; Fam166c", "gene_names_refseq": "1700001C02Rik; 1700047H18Rik; Cimip2c; Fam166c", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2C", "protein_names_refseq": "UPF0573 protein C2orf70 homolog; ciliary microtubule inner protein 2C isoform 1; family with sequence similarity 166, member C; protein FAM166C", "tax_id": 10090, "disease": "", "pathway": " (mmu:75434)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;37295417;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37989994). Binds to the intra-tubulin interfaces (PubMed:37295417)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9M8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAY5-1", "uniprot_id": [ { "id": "CF120_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAY5", "type": "external" } ], "mass": 20945.0, "length": 185, "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0669 protein C6orf120 homolog precursor", "refseq_ac": [ { "id": "NP_001077349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077349", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1600012H06Rik", "protein_names_uniprotkb": "UPF0669 protein C6orf120 homolog", "protein_names_refseq": "UPF0669 protein C6orf120 homolog precursor; UPF0669 protein C6orf120 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67912); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;34428180;35820727", "class_list": "", "function": "May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ST2;Q8CEI9;Q9CU86", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCG2-1", "uniprot_id": [ { "id": "CD302_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCG2", "type": "external" } ], "mass": 25423.0, "length": 228, "protein_name": "CD302 antigen", "gene_name": "Cd302", "organism": "Mouse", "refseq_name": "CD302 antigen isoform a precursor", "refseq_ac": [ { "id": "NP_001277589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277589", "type": "external" } ], "gene_names_uniprotkb": "Cd302; Clec13a", "gene_names_refseq": "1110055L24Rik; Cd302", "protein_names_uniprotkb": "CD302 antigen; C-type lectin domain family 13 member A; Type I transmembrane C-type lectin receptor DCL-1", "protein_names_refseq": "C-type lectin domain family 13 member A; CD302 antigen isoform a precursor; type I transmembrane C-type lectin receptor DCL-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66205)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17947679;27316686;34428180", "class_list": "glycogene", "function": "HDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration, [RefSeq, PubMed]; Multifunctional C-type lectin receptor involved in endocytosis, phagocytosis and regulation of cell adhesion and migration. Plays a critical role in guiding dendritic cells to lymph nodes., [UniProtKB, UniProtKB]; These studies confirm a functional role for CD302 in myeloid dendritic cells migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AW84;A2AW85;Q78KD8;Q9D0X7", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0016020 membrane;GO:0030175 filopodium;GO:0005902 microvillus", "go_biological_process": "GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCG2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHH6-1", "uniprot_id": [ { "id": "CBPB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHH6", "type": "external" } ], "mass": 48871.0, "length": 422, "protein_name": "Carboxypeptidase B2", "gene_name": "Cpb2", "organism": "Mouse", "refseq_name": "carboxypeptidase B2 preproprotein", "refseq_ac": [ { "id": "NP_062749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062749", "type": "external" } ], "gene_names_uniprotkb": "Cpb2; Tafi", "gene_names_refseq": "1110032P04Rik; 4930405E17Rik; CPR; Cpb2; Cpu; TAFI", "protein_names_uniprotkb": "Carboxypeptidase B2; 3.4.17.20; CPR; CPU; Carboxypeptidase R; Carboxypeptidase U; TAFI; Thrombin-activable fibrinolysis inhibitor", "protein_names_refseq": "carboxypeptidase B2 (plasma); carboxypeptidase B2 preproprotein; carboxypeptidase R; carboxypeptidase U; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); Behcet's disease (Disease Ontology:DOID:13241); thrombocytosis (Disease Ontology:DOID:2228); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56373); (R-MMU-2022377); (R-MMU-977606)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10739389;10878383;12417566;16944957;31465300;32506822;34428180;34626062;37532120", "class_list": "", "function": "Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin-dependent plasmin generation on thrombin-activated platelets., [RefSeq, PubMed]; Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice., [RefSeq, PubMed]; Brain Expression of CPB2 and Effects of Cpb2 Deficiency in Mouse Models of Behavior., [RefSeq, PubMed]; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin., [UniProtKB]; Role of pCPB as a modulator of the pivotal functions of plasminogen in fibrinolysis and cell migration in vivo., [RefSeq, PubMed]; TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBI3;Q9QZF0", "ec_number_list": [ { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" }, { "id": "3.4.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0010757 negative regulation of plasminogen activation;GO:0042730 fibrinolysis;GO:0051918 negative regulation of fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JHH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLG8-1", "uniprot_id": [ { "id": "CAN15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLG8", "type": "external" } ], "mass": 118719.0, "length": 1095, "protein_name": "Calpain-15", "gene_name": "Capn15", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capn15; Solh", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-15; 3.4.22.-; Small optic lobes homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:50817); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10708520;21750661;31219806;32885237;33951504;34428180;40238785", "class_list": "", "function": "Calcium-dependent cysteine protease that functions as a non-proteasomal, ubiquitin-directed protease regulating cell adhesion through cleavage of E-cadherin/CDH1. Binds to ubiquitinated proteins via its N-terminal, preferentially recognizing longer polyubiquitin chains including both 'Lys-48- and 'Lys-63'-linked chains. Recognizes the ubiquitinated E-cadherin-catenin complex and cleaves E-cadherin in a calcium- and ubiquitination-dependent manner resulting in lysosomal degradation of the resultant fragment (By similarity). Plays a critical role in eye, brain and cerebellar development (PubMed:33951504). In the developing brain, may regulate transcription factor abundance including PAX2 and PAX5 levels. Additional putative substrates include P-cadherin/CDH3, DCX and TUBB3 (PubMed:40238785)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEE9", "ec_number_list": [ { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JLG8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM83-1", "uniprot_id": [ { "id": "CALM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM83", "type": "external" } ], "mass": 16767.0, "length": 148, "protein_name": "Calmodulin-4", "gene_name": "Calm4", "organism": "Mouse", "refseq_name": "calmodulin-4", "refseq_ac": [ { "id": "NP_064420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064420", "type": "external" } ], "gene_names_uniprotkb": "Calm4; Dd112", "gene_names_refseq": "2310037J09Rik; Calm4; DD112; Scarf", "protein_names_uniprotkb": "Calmodulin-4; Calcium-binding protein Dd112", "protein_names_refseq": "calcium binding gene, DD112; calcium-binding protein Dd112; calmodulin-4; skin calmodulin-related factor", "tax_id": 10090, "disease": "dry eye syndrome (Disease Ontology:DOID:10140); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:80796); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15922673;17470426;25316000;33657879;34428180;36716953", "class_list": "", "function": "Calm4 is dispensable for epidermal barrier formation, maintenance and repair, [RefSeq, PubMed]; Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb., [RefSeq, PubMed]; Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis., [RefSeq, PubMed]; Expression pattern for Scarf and Scarf2 transcripts and proteins in the developing mouse epidermis., [RefSeq, PubMed]; Implicated in the early stage of ectopic ossification., [UniProtKB]; Scarf plays a critical role as a Ca2+ sensor, potentially regulating the function of its binding target proteins in a Ca2+-dependent manner in the process of restoration of epidermal Ca2+ gradient as well as during epidermal barrier formation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR31;Q9D1E9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JM83-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1P5-1", "uniprot_id": [ { "id": "CD320_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1P5", "type": "external" } ], "mass": 27739.0, "length": 260, "protein_name": "CD320 antigen", "gene_name": "Cd320", "organism": "Mouse", "refseq_name": "CD320 antigen isoform 2 precursor", "refseq_ac": [ { "id": "NP_001292098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292098", "type": "external" } ], "gene_names_uniprotkb": "Cd320", "gene_names_refseq": "425O18-1; 8D6; Cd320; D17Ertd716e; NG29; TCblR; VLDL", "protein_names_uniprotkb": "CD320 antigen; TCblR; Transcobalamin receptor", "protein_names_refseq": "CD320 antigen isoform 2 precursor; putative VLDL lipoprotein receptor; transcobalamin receptor", "tax_id": 10090, "disease": "methylmalonic acidemia due to transcobalamin receptor defect (Disease Ontology:DOID:0060741)", "pathway": " (mmu:54219)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15878964;15987942;16723719;17494763;33803025;34118252", "class_list": "", "function": "Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4., [RefSeq, PubMed]; Diabetic rats showed severe hyperlipidemia on d 21 and 28, with a dramatic decline in VLDL-R protein in skeletal muscle (>90%), heart (approximately 50%) and a loss of adipose tissues itself., [RefSeq, PubMed]; Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as a costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10., [UniProtKB, UniProtKB]; Reelin binds several receptors, including the VLDL receptor in cultured hippocampus neurons., [RefSeq, PubMed]; These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin., [RefSeq, PubMed]; VLDL and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2Q4;Q7TSW0;Q8C2Q4;Q9CWC2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008083 growth factor activity;GO:0031419 cobalamin binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation;GO:0015889 cobalamin transport;GO:0030656 regulation of vitamin metabolic process;GO:0031296 B cell costimulation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z1P5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UX62-1", "uniprot_id": [ { "id": "ODAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UX62", "type": "external" } ], "mass": 74120.0, "length": 658, "protein_name": "Outer dynein arm-docking complex subunit 1", "gene_name": "Odad1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Odad1; Ccdc114", "gene_names_refseq": "", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 1; Coiled-coil domain-containing protein 114", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary ciliary dyskinesia 20 (Disease Ontology:DOID:0110625)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;23261303;31219806", "class_list": "", "function": "Component of the outer dynein arm-docking complex that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WT0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0036157 outer dynein arm;GO:0120228 outer dynein arm docking complex", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UX62-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51680-1", "uniprot_id": [ { "id": "CCR4_MOUSE", "url": "https://www.uniprot.org/uniprot/P51680", "type": "external" } ], "mass": 41408.0, "length": 360, "protein_name": "C-C chemokine receptor type 4", "gene_name": "Ccr4", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 4", "refseq_ac": [ { "id": "NP_034046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034046", "type": "external" } ], "gene_names_uniprotkb": "Ccr4; Cmkbr4", "gene_names_refseq": "C-C CKR-4; CHEMR1; Ccr4; Cmkbr4; LESTR; Sdf1r", "protein_names_uniprotkb": "C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4", "protein_names_refseq": "C-C chemokine receptor type 4; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; fusin; leukocyte-expressed seven-transmembrane-domain receptor", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); pulmonary fibrosis (Disease Ontology:DOID:3770); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:12773); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10811868;21750661;30779550;38702399;8573157;9192769", "class_list": "", "function": "High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival., [UniProtKB, PubMed]; Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14A03", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51680-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AUP1-1", "uniprot_id": [ { "id": "CC112_MOUSE", "url": "https://www.uniprot.org/uniprot/A0AUP1", "type": "external" } ], "mass": 52777.0, "length": 442, "protein_name": "Coiled-coil domain-containing protein 112", "gene_name": "Ccdc112", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccdc112", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 112", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:240261)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AUP2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0AUP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJB1-1", "uniprot_id": [ { "id": "CC183_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJB1", "type": "external" } ], "mass": 62117.0, "length": 534, "protein_name": "Coiled-coil domain-containing protein 183", "gene_name": "Ccdc183", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 183", "refseq_ac": [ { "id": "NP_084135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084135", "type": "external" } ], "gene_names_uniprotkb": "Ccdc183; Kiaa1984", "gene_names_refseq": "4921530D09Rik; Cccd183; Ccdc183; Kiaa1984", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 183", "protein_names_refseq": "coiled-coil domain-containing protein 183", "tax_id": 10090, "disease": "", "pathway": " (mmu:77058)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;37882665", "class_list": "", "function": "CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5S3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0000226 microtubule cytoskeleton organization;GO:0007028 cytoplasm organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AJB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UJP5-1", "uniprot_id": [ { "id": "CF418_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UJP5", "type": "external" } ], "mass": 23848.0, "length": 209, "protein_name": "Cilia- and flagella-associated protein 418", "gene_name": "Cfap418", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 418", "refseq_ac": [ { "id": "NP_080281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080281", "type": "external" } ], "gene_names_uniprotkb": "Cfap418; 2610301B20Rik", "gene_names_refseq": "2610301B20Rik; Cfap418", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 418", "protein_names_refseq": "cilia- and flagella-associated protein 418; protein C8orf37 homolog", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 21 (Disease Ontology:DOID:0081010); cone-rod dystrophy 16 (Disease Ontology:DOID:0111022); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:67157)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22177090;29440555;37971880", "class_list": "", "function": "Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in photoreceptor outer segment disk morphogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDD5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0097546 ciliary base", "go_biological_process": "GO:0008594 photoreceptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UJP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56198-1", "uniprot_id": [ { "id": "CIDEC_MOUSE", "url": "https://www.uniprot.org/uniprot/P56198", "type": "external" } ], "mass": 27324.0, "length": 239, "protein_name": "Lipid transferase CIDEC", "gene_name": "Cidec", "organism": "Mouse", "refseq_name": "lipid transferase CIDEC isoform 1", "refseq_ac": [ { "id": "NP_001288224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288224", "type": "external" } ], "gene_names_uniprotkb": "Cidec; Fsp27", "gene_names_refseq": "CIDE-3; Cidec; Fsp27", "protein_names_uniprotkb": "Lipid transferase CIDEC; Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27", "protein_names_refseq": "CIDE-3alpha; cell death activator CIDE-3; cell death-inducing DFFA-like effector protein C; fat specific gene 27; fat-specific protein FSP27; lipid transferase CIDEC isoform 1; lipid transferase CIDEC", "tax_id": 10090, "disease": "familial partial lipodystrophy type 5 (Disease Ontology:DOID:0070203)", "pathway": " (mmu:14311); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12910269;1339452;17884815;18334488;18509062;18654663;18682832;20089860;21750661;22144693;22245780;23233732;23481402;24025675;26733203;30361435;34508658;36263170;36477540", "class_list": "", "function": "FSP27/Cidec as a novel adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation., [RefSeq, PubMed]; Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:22144693, PubMed:26733203, PubMed:30361435, PubMed:36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:18682832, PubMed:22144693, PubMed:26733203). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:22144693). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:22144693). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23481402). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (PubMed:22245780). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 31, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499X5;Q8BNV7", "ec_number_list": [], "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding;GO:0070300 phosphatidic acid binding;GO:0120013 lipid transfer activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0090209 negative regulation of triglyceride metabolic process;GO:0006915 apoptotic process;GO:0050995 negative regulation of lipid catabolic process;GO:0097194 execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P56198-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18181-1", "uniprot_id": [ { "id": "CD48_MOUSE", "url": "https://www.uniprot.org/uniprot/P18181", "type": "external" } ], "mass": 27383.0, "length": 240, "protein_name": "CD48 antigen", "gene_name": "Cd48", "organism": "Mouse", "refseq_name": "CD48 antigen isoform 1 precursor", "refseq_ac": [ { "id": "NP_031675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031675", "type": "external" } ], "gene_names_uniprotkb": "Cd48; Bcm-1", "gene_names_refseq": "BCM1; BLAST-1; BLAST1; BLAST; Bcm-1; Cd48; MEM-102; SLAMF2; Sgp-60", "protein_names_uniprotkb": "CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; sgp-60", "protein_names_refseq": "BCM1 surface antigen; CD48 antigen isoform 1 precursor; HM48-1; MRC OX-45 surface antigen; SLAM family member 2; signaling lymphocytic activation molecule 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12506); (R-MMU-202733)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;1383383;1693656;17950006;21278219;21750661;30084848;30779550;34428180;36520044;38386559;8475091;9881969", "class_list": "", "function": "Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease., [RefSeq, PubMed]; Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:21278219, PubMed:9881969). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:21278219, PubMed:9881969)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q545K2", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0042110 T cell activation;GO:0030101 natural killer cell activation;GO:0045576 mast cell activation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P18181-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QPZ5-1", "uniprot_id": [ { "id": "CFA73_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QPZ5", "type": "external" } ], "mass": 35671.0, "length": 306, "protein_name": "Cilia- and flagella-associated protein 73", "gene_name": "Cfap73", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 73", "refseq_ac": [ { "id": "NP_001182023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182023", "type": "external" } ], "gene_names_uniprotkb": "Cfap73; Ccdc42b", "gene_names_refseq": "546886; Ccdc42b; Cfap73; Gm5988", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 73; Coiled-coil domain-containing protein 42B", "protein_names_refseq": "cilia- and flagella-associated protein 73; coiled-coil domain containing 42B; coiled-coil domain-containing protein 42B", "tax_id": 10090, "disease": "", "pathway": " (mmu:546886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0097545 axonemal doublet microtubule", "go_biological_process": "GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "J3QPZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60824-1", "uniprot_id": [ { "id": "CIRBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P60824", "type": "external" } ], "mass": 18607.0, "length": 172, "protein_name": "Cold-inducible RNA-binding protein", "gene_name": "Cirbp", "organism": "Mouse", "refseq_name": "cold-inducible RNA-binding protein isoform 1", "refseq_ac": [ { "id": "NP_031731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031731", "type": "external" } ], "gene_names_uniprotkb": "Cirbp; Cirp", "gene_names_refseq": "Cirbp; Cirp", "protein_names_uniprotkb": "Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP", "protein_names_refseq": "A18 hnRNP; cold-inducible RNA-binding protein isoform 1; glycine-rich RNA-binding protein CIRP", "tax_id": 10090, "disease": "", "pathway": " (mmu:12696)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17967451;21750661;38531201;38881891;38938563;9151692", "class_list": "", "function": "BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance. Publication Status: Online-Only, [RefSeq, PubMed]; CIRP increases Foxp3[+] regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis., [RefSeq, PubMed]; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN., [UniProtKB, PubMed, PubMed]; Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09069;O09148;Q3V1A6;Q61413", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003730 mRNA 3'-UTR binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070417 cellular response to cold;GO:0048255 mRNA stabilization;GO:0030308 negative regulation of cell growth;GO:0009411 response to UV;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60824-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55186-1", "uniprot_id": [ { "id": "CD59A_MOUSE", "url": "https://www.uniprot.org/uniprot/O55186", "type": "external" } ], "mass": 13648.0, "length": 123, "protein_name": "CD59A glycoprotein", "gene_name": "Cd59a", "organism": "Mouse", "refseq_name": "CD59A glycoprotein precursor", "refseq_ac": [ { "id": "NP_001104530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104530", "type": "external" } ], "gene_names_uniprotkb": "Cd59a; Cd59", "gene_names_refseq": "Cd59a; Cd59; MAC-IP; MACIF", "protein_names_uniprotkb": "CD59A glycoprotein; MAC-IP; MAC-inhibitory protein; MACIF; Membrane attack complex inhibition factor; Protectin", "protein_names_refseq": "CD59 antigen; CD59A glycoprotein precursor; CD59A glycoprotein; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); endometrial cancer (Disease Ontology:DOID:1380); anterior uveitis (Disease Ontology:DOID:1407); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:12509)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10965140;9029105", "class_list": "", "function": "Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q542R7", "ec_number_list": [], "go_molecular_function": "GO:0001848 complement binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0016525 negative regulation of angiogenesis;GO:0042102 positive regulation of T cell proliferation;GO:0045916 negative regulation of complement activation;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55186-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55226-1", "uniprot_id": [ { "id": "CHAD_MOUSE", "url": "https://www.uniprot.org/uniprot/O55226", "type": "external" } ], "mass": 40349.0, "length": 358, "protein_name": "Chondroadherin", "gene_name": "Chad", "organism": "Mouse", "refseq_name": "chondroadherin precursor", "refseq_ac": [ { "id": "NP_031715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031715", "type": "external" } ], "gene_names_uniprotkb": "Chad", "gene_names_refseq": "Chad; SLRR4A", "protein_names_uniprotkb": "Chondroadherin; Cartilage leucine-rich protein", "protein_names_refseq": "cartilage leucine-rich protein; chondroadherin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:12643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9465299", "class_list": "", "function": "Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0060348 bone development;GO:1900155 negative regulation of bone trabecula formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O55226-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70303-1", "uniprot_id": [ { "id": "CIDEB_MOUSE", "url": "https://www.uniprot.org/uniprot/O70303", "type": "external" } ], "mass": 24800.0, "length": 219, "protein_name": "Lipid transferase CIDEB", "gene_name": "Cideb", "organism": "Mouse", "refseq_name": "lipid transferase CIDEB", "refseq_ac": [ { "id": "NP_034024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034024", "type": "external" } ], "gene_names_uniprotkb": "Cideb", "gene_names_refseq": "1110030C18Rik; CIDE-B; Cideb", "protein_names_uniprotkb": "Lipid transferase CIDEB; Cell death activator CIDE-B; Cell death-inducing DFFA-like effector B", "protein_names_refseq": "DFFA-like B; cell death activator CIDE-B; cell death-inducing DFFA-like effector B; lipid transferase CIDEB", "tax_id": 10090, "disease": "", "pathway": " (mmu:12684)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;17646209;19187774;23297397;26733203;28719542;30858281;34428180;9564035", "class_list": "", "function": "Cideb is a novel important regulator in lipid metabolism in the liver and may thus represent a new therapeutic target for the treatment of obesity, diabetes, and liver steatosis, [RefSeq, PubMed]; Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice., [RefSeq, PubMed]; High Cideb expression is associated with Ulcerative Colitis., [RefSeq, PubMed]; Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:26733203). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:26733203). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (PubMed:26733203). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (PubMed:19187774, PubMed:23297397, PubMed:30858281). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (PubMed:19187774, PubMed:23297397). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (PubMed:23297397). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (PubMed:30858281). May also activate apoptosis (PubMed:9564035)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X39", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0070300 phosphatidic acid binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0034379 very-low-density lipoprotein particle assembly;GO:0097194 execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70303-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88199-1", "uniprot_id": [ { "id": "CHST3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88199", "type": "external" } ], "mass": 53997.0, "length": 472, "protein_name": "Carbohydrate sulfotransferase 3", "gene_name": "Chst3", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 3", "refseq_ac": [ { "id": "NP_001393954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001393954", "type": "external" } ], "gene_names_uniprotkb": "Chst3; C6st; Gst0", "gene_names_refseq": "C6ST-1; C6ST; Chst3; GST-0", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 3; 2.8.2.17; 2.8.2.21; C6ST-1; C6ST; Chondroitin 6-O-sulfotransferase 1; Chondroitin 6-sulfotransferase; GST-0; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0", "protein_names_refseq": "carbohydrate (chondroitin 6/keratan) sulfotransferase 3; carbohydrate sulfotransferase 3; chondroitin 6-O-sulfotransferase 1; chondroitin 6-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0", "tax_id": 10090, "disease": "spondyloepiphyseal dysplasia with congenital joint dislocations (Disease Ontology:DOID:0050813); osteochondrodysplasia (Disease Ontology:DOID:2256); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:53374); (R-MMU-2022854); (R-MMU-2022870)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11696535;26495903;26646821;32152506;9597547", "class_list": "glycogene", "function": "CHST3 siRNA diminishes accumulation of excessive macrophages and the mediators, leading to accelerate the functional recovery from airway damage by repair of the elastin network associated with pulmonary emphysema Publication Status: Online-Only, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:11696535, PubMed:9597547). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9597547). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:11696535). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (PubMed:11696535)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q794I5", "ec_number_list": [ { "id": "2.8.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.17", "type": "external" }, { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" }, { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008459 chondroitin 6-sulfotransferase activity;GO:0050698 proteoglycan sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0043029 T cell homeostasis;GO:0006790 sulfur compound metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88199-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C242-1", "uniprot_id": [ { "id": "CCNO_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C242", "type": "external" } ], "mass": 38822.0, "length": 352, "protein_name": "Cyclin-O", "gene_name": "Ccno", "organism": "Mouse", "refseq_name": "cyclin-O", "refseq_ac": [ { "id": "NP_001074531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074531", "type": "external" } ], "gene_names_uniprotkb": "Ccno", "gene_names_refseq": "Ccno; Ccnu; E130318K11; UDG2; Ung2", "protein_names_uniprotkb": "Cyclin-O", "protein_names_refseq": "cyclin U; cyclin-O; cyclin-like uracil-DNA glycosylase; uracil DNA glycosylase 2", "tax_id": 10090, "disease": "primary ciliary dyskinesia 29 (Disease Ontology:DOID:0110600)", "pathway": " (mmu:218630)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16697536;18927588;19609756;24747639;26777464;30936178", "class_list": "", "function": "Cyclin O activation correlates with apoptosis induction in vivo., [RefSeq, PubMed]; Data show defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice Publication Status: Online-Only, [RefSeq, PubMed]; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involved in oocyte meiotic resumption in oocytes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0051301 cell division;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7M9-1", "uniprot_id": [ { "id": "CLC2L_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C7M9", "type": "external" } ], "mass": 23653.0, "length": 211, "protein_name": "C-type lectin domain family 2 member L", "gene_name": "Clec2l", "organism": "Mouse", "refseq_name": "C-type lectin domain family 2 member L", "refseq_ac": [ { "id": "NP_001094977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094977", "type": "external" } ], "gene_names_uniprotkb": "Clec2l", "gene_names_refseq": "665180; Clec2l; Gm1064", "protein_names_uniprotkb": "C-type lectin domain family 2 member L", "protein_names_refseq": "C-type lectin domain family 2 member L; C-type lectin domain family, member L", "tax_id": 10090, "disease": "", "pathway": " (mmu:665180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C7M9-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11610-1", "uniprot_id": [ { "id": "CD1D2_MOUSE", "url": "https://www.uniprot.org/uniprot/P11610", "type": "external" } ], "mass": 38477.0, "length": 336, "protein_name": "Antigen-presenting glycoprotein CD1d2", "gene_name": "Cd1d2", "organism": "Mouse", "refseq_name": "antigen-presenting glycoprotein CD1d2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_031666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031666", "type": "external" } ], "gene_names_uniprotkb": "Cd1d2; Cd1.2", "gene_names_refseq": "CD1.2; Cd1b; Cd1d2; Ly-38", "protein_names_uniprotkb": "Antigen-presenting glycoprotein CD1d2", "protein_names_refseq": "T-cell surface glycoprotein CD1d2; antigen-presenting glycoprotein CD1d2 isoform 1 precursor; antigen-presenting glycoprotein CD1d2", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); dengue hemorrhagic fever (Disease Ontology:DOID:12206); urinary schistosomiasis (Disease Ontology:DOID:1394); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:12480)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1702817;20173027;2460336;38040679", "class_list": "", "function": "Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells., [UniProtKB]; Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. Alternatively splice transcript variants encoding different isoforms have been found in non-C57BL/6 strains. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0030883 endogenous lipid antigen binding;GO:0030884 exogenous lipid antigen binding;GO:0071723 lipopeptide binding;GO:0030882 lipid antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0005764 lysosome", "go_biological_process": "GO:0051135 positive regulation of NK T cell activation;GO:0006955 immune response;GO:0045087 innate immune response;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11610-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22518-1", "uniprot_id": [ { "id": "CLK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P22518", "type": "external" } ], "mass": 57093.0, "length": 483, "protein_name": "Dual specificity protein kinase CLK1", "gene_name": "Clk1", "organism": "Mouse", "refseq_name": "dual specificity protein kinase CLK1", "refseq_ac": [ { "id": "NP_001036099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036099", "type": "external" } ], "gene_names_uniprotkb": "Clk1; Clk; Sty", "gene_names_refseq": "Clk1; STY", "protein_names_uniprotkb": "Dual specificity protein kinase CLK1; 2.7.12.1; CDC-like kinase 1; Protein kinase STY", "protein_names_refseq": "dual specificity protein kinase CLK1; protein kinase STY", "tax_id": 10090, "disease": "", "pathway": " (mmu:12747)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;1825055;1986248;21183079;21615147;30084848;31176694;31219806;34428180;36210013;39927985;7665564;7990150;8617202;9307018;9315658", "class_list": "", "function": "Cdc-like kinase 1 (CLK1) knockdown reduces influenza A replication and increased the level of splicing of segment 7, which encodes the viral M1 and M2 proteins. CLK1-/- mice infected with influenza A virus supports lower levels of virus replication than wild-type mice., [RefSeq, PubMed]; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates (PubMed:1825055, PubMed:1986248, PubMed:9307018). Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:8617202, PubMed:9307018). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6K2;Q3UXB6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation;GO:0046777 protein autophosphorylation;GO:0018107 peptidyl-threonine phosphorylation;GO:0018105 peptidyl-serine phosphorylation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P22518-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40240-1", "uniprot_id": [ { "id": "CD9_MOUSE", "url": "https://www.uniprot.org/uniprot/P40240", "type": "external" } ], "mass": 25258.0, "length": 226, "protein_name": "CD9 antigen", "gene_name": "Cd9", "organism": "Mouse", "refseq_name": "CD9 antigen", "refseq_ac": [ { "id": "NP_031683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031683", "type": "external" } ], "gene_names_uniprotkb": "Cd9", "gene_names_refseq": "Cd9; Tspan29", "protein_names_uniprotkb": "CD9 antigen", "protein_names_refseq": "CD9 antigen", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); severe acute respiratory syndrome (Disease Ontology:DOID:2945); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:12527); (R-MMU-114608); (R-MMU-1300645)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10518536;10634790;10634791;10700183;11805154;11934865;12796480;14715942;18662991;21690351;23213457;23575678;25209248;26109643;26740625;8236164", "class_list": "", "function": "Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:10634790, PubMed:10634791, PubMed:10700183, PubMed:14715942). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (PubMed:10634790, PubMed:10634791, PubMed:10700183, PubMed:21690351). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (PubMed:12796480). Acts as a receptor for PSG17 (PubMed:11805154). Involved in platelet activation and aggregation (PubMed:14715942). Regulates paranodal junction formation (PubMed:14715942). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9W0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008285 negative regulation of cell population proliferation;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40240-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41209-1", "uniprot_id": [ { "id": "CETN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P41209", "type": "external" } ], "mass": 19696.0, "length": 172, "protein_name": "Centrin-1", "gene_name": "Cetn1", "organism": "Mouse", "refseq_name": "centrin-1", "refseq_ac": [ { "id": "NP_031619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031619", "type": "external" } ], "gene_names_uniprotkb": "Cetn1; Calt", "gene_names_refseq": "Cetn1; caltractin", "protein_names_uniprotkb": "Centrin-1; Caltractin", "protein_names_refseq": "centrin-1; testis-specific murine centrin", "tax_id": 10090, "disease": "", "pathway": " (mmu:26369); (R-MMU-9646399)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10486202;11884606;20643351;27530713;29037133;30120214;8218402", "class_list": "", "function": "Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells, [RefSeq, PubMed]; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (PubMed:27530713)., [UniProtKB, UniProtKB, PubMed]; The crystal structure exhibits three structural features, i.e. four Ca2+ equally occupied at each EF-hand motif, structural changes accompanying helix motion at the N- and C-lobes, and adoption of N-C type dimerization when Ca2+ binds to EF-hand I and II in the N-lobe., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V119;Q9D9G9;Q9DAL6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0032795 heterotrimeric G-protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051301 cell division;GO:0034605 cellular response to heat;GO:0000226 microtubule cytoskeleton organization;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P41209-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56390-1", "uniprot_id": [ { "id": "CKS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P56390", "type": "external" } ], "mass": 9874.0, "length": 79, "protein_name": "Cyclin-dependent kinases regulatory subunit 2", "gene_name": "Cks2", "organism": "Mouse", "refseq_name": "cyclin-dependent kinases regulatory subunit 2", "refseq_ac": [ { "id": "NP_079691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079691", "type": "external" } ], "gene_names_uniprotkb": "Cks2", "gene_names_refseq": "1110038L14Rik; CKSHS2; Cks2", "protein_names_uniprotkb": "Cyclin-dependent kinases regulatory subunit 2; CKS-2", "protein_names_refseq": "CKS-2; cyclin-dependent kinases regulatory subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66197)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12714746;18498131;26156959;30988159;34428180", "class_list": "", "function": "Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function., [UniProtKB]; Elevated expression of Cks1 may contribute to prostate tumorigenesis by promoting proliferation, anchorage-independent growth and migration of the cells, and elevated expression of Cks2 by protecting cells from undergoing programmed cell death., [RefSeq, PubMed]; Mice lacking Cks2 were viable but sterile in both sexes; Cks2 is required for the first metaphase/anaphase transition of meiosis, [RefSeq, PubMed]; New direct Wnt/beta-catenin target gene Cks2 , which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified., [RefSeq, PubMed]; Study shows that CKS2 is a crucial regulator of maturation-promoting factor (MPF) activity during meiosis and that its deletion in oocytes results in delayed MPF activation and germinal vesicle breakdown and defective spindle assembly. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0044772 mitotic cell cycle phase transition;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56390-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBV7-1", "uniprot_id": [ { "id": "CE126_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBV7", "type": "external" } ], "mass": 123685.0, "length": 1103, "protein_name": "Centrosomal protein of 126 kDa", "gene_name": "Cep126", "organism": "Mouse", "refseq_name": "centrosomal protein of 126 kDa isoform 1", "refseq_ac": [ { "id": "NP_001038989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038989", "type": "external" } ], "gene_names_uniprotkb": "Cep126; Kiaa1377", "gene_names_refseq": "Cep126; mKIAA1377", "protein_names_uniprotkb": "Centrosomal protein of 126 kDa", "protein_names_refseq": "centrosomal protein of 126 kDa isoform 1; centrosomal protein of 126 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:234915)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Participate in cytokinesis (By similarity). Necessary for microtubules and mitotic spindle organization (By similarity). Involved in primary cilium formation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPS8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0097546 ciliary base", "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0007052 mitotic spindle organization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VBV7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VG85-5", "uniprot_id": [ { "id": "CC162_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VG85", "type": "external" } ], "mass": 104336.0, "length": 912, "protein_name": "Coiled-coil domain-containing protein 162", "gene_name": "Ccdc162", "organism": "Mouse", "refseq_name": "coiled-coil domain containing 162", "refseq_ac": [ { "id": "NP_001345491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001345491", "type": "external" } ], "gene_names_uniprotkb": "Ccdc162", "gene_names_refseq": "5033413D22Rik; Ccdc162p; Ccdc162; Gm29096; Gm61; Gm6976", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 162", "protein_names_refseq": "coiled-coil domain containing 162; coiled-coil domain-containing protein 162", "tax_id": 10090, "disease": "", "pathway": " (mmu:75973)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WRU3;Q3UUY5;Q3V339", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VG85-5", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UKK2-1", "uniprot_id": [ { "id": "CEAM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UKK2", "type": "external" } ], "mass": 106270.0, "length": 947, "protein_name": "Cell adhesion molecule CEACAM5", "gene_name": "Ceacam5", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM5 precursor", "refseq_ac": [ { "id": "NP_082756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082756", "type": "external" } ], "gene_names_uniprotkb": "Ceacam5; Psg30", "gene_names_refseq": "1600029H12Rik; Ceacam5; Psg30", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM5; CEA cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5; Pregnancy-specific glycoprotein 30", "protein_names_refseq": "carcinoembryonic antigen-related cell adhesion molecule 5; cell adhesion molecule CEACAM5 precursor; cell adhesion molecule CEACAM5; pregnancy-specific glycoprotein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:73250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15647114;24388361;30059200;38686388", "class_list": "", "function": "A new mechanistic insight into how the CEA IgV-like N domain participates in cellular events that can have a macroscopic impact in terms of cancer progression and metastasis., [RefSeq, PubMed]; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells., [UniProtKB, UniProtKB]; SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0006915 apoptotic process;GO:0042110 T cell activation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UKK2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URS9-1", "uniprot_id": [ { "id": "MITOK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URS9", "type": "external" } ], "mass": 45132.0, "length": 406, "protein_name": "Mitochondrial potassium channel", "gene_name": "Ccdc51", "organism": "Mouse", "refseq_name": "mitochondrial potassium channel", "refseq_ac": [ { "id": "NP_079965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079965", "type": "external" } ], "gene_names_uniprotkb": "Ccdc51; Mitok", "gene_names_refseq": "5730568A12Rik; Ccdc51; Mitok", "protein_names_uniprotkb": "Mitochondrial potassium channel; Coiled-coil domain-containing protein 51; MITOK", "protein_names_refseq": "coiled-coil domain-containing protein 51; mitochondrial potassium channel", "tax_id": 10090, "disease": "", "pathway": " (mmu:66658)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31435016", "class_list": "", "function": "Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQL1;Q9CXS1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0062156 mitochondrial ATP-gated potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0062157 mitochondrial ATP-gated potassium channel complex", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0071805 potassium ion transmembrane transport;GO:0140141 mitochondrial potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3URS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZRW6-1", "uniprot_id": [ { "id": "CLUL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ZRW6", "type": "external" } ], "mass": 53733.0, "length": 464, "protein_name": "Clusterin-like protein 1", "gene_name": "Clul1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clul1", "gene_names_refseq": "", "protein_names_uniprotkb": "Clusterin-like protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZRW6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTK1-1", "uniprot_id": [ { "id": "CHSS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTK1", "type": "external" } ], "mass": 100099.0, "length": 884, "protein_name": "Chondroitin sulfate synthase 3", "gene_name": "Chsy3", "organism": "Mouse", "refseq_name": "chondroitin sulfate synthase 3", "refseq_ac": [ { "id": "NP_001074797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074797", "type": "external" } ], "gene_names_uniprotkb": "Chsy3; Chsy2; Css3; Kiaa4168", "gene_names_refseq": "4833446K15Rik; Chsy3", "protein_names_uniprotkb": "Chondroitin sulfate synthase 3; 2.4.1.175; 2.4.1.226; Carbohydrate synthase 2; ChSy-2; Chondroitin glucuronyltransferase 3; Chondroitin synthase 2; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3; N-acetylgalactosaminyltransferase 3", "protein_names_refseq": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3; N-acetylgalactosaminyltransferase 3; carbohydrate synthase 2; chSy-2; chondroitin glucuronyltransferase 3; chondroitin sulfate synthase 3; chondroitin synthase 2; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II", "tax_id": 10090, "disease": "", "pathway": " (mmu:78923); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;20485683;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RXU7", "ec_number_list": [ { "id": "2.4.1.175", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.175", "type": "external" }, { "id": "2.4.1.226", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.226", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5DTK1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F201-1", "uniprot_id": [ { "id": "CFA52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5F201", "type": "external" } ], "mass": 68240.0, "length": 620, "protein_name": "Cilia- and flagella-associated protein 52", "gene_name": "Cfap52", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 52", "refseq_ac": [ { "id": "NP_082239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082239", "type": "external" } ], "gene_names_uniprotkb": "Cfap52; Wdr16", "gene_names_refseq": "1700019F09Rik; 4933417B11Rik; Cfap52; WDRPUH; Wdr16", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 52; WD repeat-containing protein 16", "protein_names_refseq": "WD repeat domain 16; WD repeat-containing protein 16; WD40-repear protein upregulated in HCC; cilia- and flagella-associated protein 52", "tax_id": 10090, "disease": "visceral heterotaxy 10 (Disease Ontology:DOID:0051024)", "pathway": " (mmu:71860)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15967112;17971504;34203471;37295417;37865089;37989994", "class_list": "", "function": "Human WDRPUH is a novel WD-repeat-containing protein involved in cell proliferation., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:37295417, PubMed:37865089, PubMed:37989994). Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11 (By similarity). May play a role in cell growth and/or survival (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Wdr16 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F200;Q9D432;Q9DA68", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0097225 sperm midpiece;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5F201-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M6W3-1", "uniprot_id": [ { "id": "CLHC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5M6W3", "type": "external" } ], "mass": 69414.0, "length": 596, "protein_name": "Clathrin heavy chain linker domain-containing protein 1", "gene_name": "Clhc1", "organism": "Mouse", "refseq_name": "clathrin heavy chain linker domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001156993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156993", "type": "external" } ], "gene_names_uniprotkb": "Clhc1", "gene_names_refseq": "1700034F02Rik; Clhc1", "protein_names_uniprotkb": "Clathrin heavy chain linker domain-containing protein 1", "protein_names_refseq": "clathrin heavy chain linker domain-containing protein 1 isoform 2; clathrin heavy chain linker domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73324)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ04;Q9D9Q4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M6W3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2C5-1", "uniprot_id": [ { "id": "MTM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2C5", "type": "external" } ], "mass": 69559.0, "length": 603, "protein_name": "Myotubularin", "gene_name": "Mtm1", "organism": "Mouse", "refseq_name": "myotubularin isoform 1", "refseq_ac": [ { "id": "NP_001157662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157662", "type": "external" } ], "gene_names_uniprotkb": "Mtm1", "gene_names_refseq": "Mtm1; Mtm; mKIAA4176", "protein_names_uniprotkb": "Myotubularin; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "myotubularin isoform 1; myotubularin; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:17772); (R-MMU-1660499); (R-MMU-1660516); (R-MMU-1660517)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "12118066;12391329;12467733;21135508;21750661;23818870;34428180;36408764;37139790;38805272;9736772", "class_list": "", "function": "BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes., [RefSeq, PubMed]; Disrupted T-tubular network accounts for asynchronous calcium release in MTM1-deficient skeletal muscle., [RefSeq, PubMed]; Essential for skeletal muscle maintenance but not for myogenesis, [RefSeq, PubMed]; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology (By similarity). Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:12391329). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; MTM1-mediated production of phosphatidylinositol 5-phosphate fuels the formation of podosome-like protrusions regulating myoblast fusion., [RefSeq, PubMed]; The investigation of the MTM1 gene and X-inactivation studies are indicated in isolated females with histopathological and clinical findings suggestive of myotubular myopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKQ5", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0004721 phosphoprotein phosphatase activity;GO:0019215 intermediate filament binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005770 late endosome", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0046716 muscle cell cellular homeostasis;GO:0008333 endosome to lysosome transport;GO:0032007 negative regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z2C5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61294-1", "uniprot_id": [ { "id": "RAB6B_MOUSE", "url": "https://www.uniprot.org/uniprot/P61294", "type": "external" } ], "mass": 23462.0, "length": 208, "protein_name": "Ras-related protein Rab-6B", "gene_name": "Rab6b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-6B", "refseq_ac": [ { "id": "NP_776142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776142", "type": "external" } ], "gene_names_uniprotkb": "Rab6b; D9Bwg0185e", "gene_names_refseq": "9630015C03; C330006L04Rik; D9Bwg0185e; Rab6b", "protein_names_uniprotkb": "Ras-related protein Rab-6B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-6B", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:270192); (R-MMU-6811436); (R-MMU-6811440); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "20360680;21750661;21913724;33300544;34555867", "class_list": "", "function": "Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Recruits VPS13B to the Golgi membrane. Regulates the compacted morphology of the Golgi. Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. Plays a role in neuron projection development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61294-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60989-1", "uniprot_id": [ { "id": "XIAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60989", "type": "external" } ], "mass": 56079.0, "length": 496, "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "Xiap", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase XIAP", "refseq_ac": [ { "id": "NP_001288568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288568", "type": "external" } ], "gene_names_uniprotkb": "Xiap; Aipa; Api3; Birc4; Miha", "gene_names_refseq": "1110015C02Rik; Aipa; Api3; Birc4; IAP3; ILP-1; MIHA; Xiap", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase XIAP; 2.3.2.27; Baculoviral IAP repeat-containing protein 4; IAP homolog A; IAP-3; Inhibitor of apoptosis protein 3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; mIAP-3; mIAP3", "protein_names_refseq": "E3 ubiquitin-protein ligase XIAP; IAP homolog A; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; baculoviral IAP repeat-containing protein 4; inhibitor of apoptosis protein 3", "tax_id": 10090, "disease": "X-linked lymphoproliferative syndrome 2 (Disease Ontology:DOID:0060706); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); breast ductal carcinoma (Disease Ontology:DOID:3007); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11798); (R-MMU-111459); (R-MMU-111463); (R-MMU-111464); (R-MMU-111469); (R-MMU-3769402); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5675482); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-9627069); (R-MMU-9958825)", "pathway_count": 14, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18761086;19473982;21750661;23788729;29452636;30389919;30779550;34428180;38351372;8643514", "class_list": "", "function": "Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (By similarity). Acts as a direct caspase inhibitor (By similarity). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (By similarity). Inhibits apoptosis in intestinal crypt cells, its activity is mitigated via its interaction with SEPTIN4 isoform ARTS (PubMed:30389919). Inactivates CASP9 by keeping it in a monomeric, inactive state (By similarity). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:18761086, PubMed:19473982). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:29452636). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (By similarity). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (By similarity). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (By similarity). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (By similarity). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (By similarity). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (By similarity). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (By similarity). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (By similarity). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (By similarity). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (By similarity). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (By similarity). Positive regulator of dermal wound repair, potentially via its interaction with SEPTIN4 (PubMed:23788729)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]; XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BGY6;O08865", "ec_number_list": [ { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.60", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60989-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERD7-1", "uniprot_id": [ { "id": "TBB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERD7", "type": "external" } ], "mass": 50419.0, "length": 450, "protein_name": "Tubulin beta-3 chain", "gene_name": "Tubb3", "organism": "Mouse", "refseq_name": "tubulin beta-3 chain", "refseq_ac": [ { "id": "NP_075768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075768", "type": "external" } ], "gene_names_uniprotkb": "Tubb3", "gene_names_refseq": "3200002H15Rik; M(beta)3; M(beta)6; Tubb3", "protein_names_uniprotkb": "Tubulin beta-3 chain", "protein_names_refseq": "betaIII-tubulin; tubulin beta-3 chain", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); congenital fibrosis of the extraocular muscles (Disease Ontology:DOID:0080143); congenital fibrosis of the extraocular muscles 3A (Disease Ontology:DOID:0081017); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 1 (Disease Ontology:DOID:0090137); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (mmu:22152); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 24, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15890843;16371510;19524510;20074521;20665223;21750661;22645316;23897886;26586574;28483977;33300544;33414192;33725478;34418053;35820727;40684658", "class_list": "", "function": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF42;Q5I036", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance;GO:0038007 netrin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9ERD7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8Y7-1", "uniprot_id": [ { "id": "TP8L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8Y7", "type": "external" } ], "mass": 20615.0, "length": 184, "protein_name": "Tumor necrosis factor alpha-induced protein 8-like protein 2", "gene_name": "Tnfaip8l2", "organism": "Mouse", "refseq_name": "tumor necrosis factor alpha-induced protein 8-like protein 2", "refseq_ac": [ { "id": "NP_081482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081482", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip8l2", "gene_names_refseq": "1810019A08Rik; TIPE2; Tnfaip8l2", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2", "protein_names_refseq": "TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; tumor necrosis factor alpha-induced protein 8-like protein 2; tumor necrosis factor, alpha-induced protein 8-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69769); (R-MMU-1483255)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18455983;20663561;21466895;21963221;22859306;31219806;34428180;34524845;35101901;35528518;36179971;36216021;39095992", "class_list": "", "function": "Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:18455983). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:34524845). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (PubMed:34524845)., [UniProtKB, PubMed, UniProtKB, PubMed]; TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice., [RefSeq, PubMed]; TIPE2 expression was detected in various murine tissues by immunohistochemistry & RT-PCR. TIPE2 was a cytoplasmic protein expressed preferentially in lymphoid tissues and a small group of non-lymphoid tissues., [RefSeq, PubMed]; TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence., [RefSeq, PubMed]; TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-gamma-mediated ferroptosis., [RefSeq, PubMed]; TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia., [RefSeq, PubMed]; The results suggested that TIPE2 appeared to be a critical immunoregulatory molecule involved in immunosuppressive function of CD4(+)CD25(+) Tregs., [RefSeq, PubMed]; These results indicate that TIPE2 plays an important role in taming Hepatitis B virus-induced hepatic inflammation., [RefSeq, PubMed]; This paper establishes that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis., [RefSeq, PubMed]; Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0050728 negative regulation of inflammatory response;GO:0042981 regulation of apoptotic process;GO:1902531 regulation of intracellular signal transduction;GO:0050868 negative regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D8Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U308-1", "uniprot_id": [ { "id": "CTU2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U308", "type": "external" } ], "mass": 56105.0, "length": 514, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 2", "gene_name": "Ctu2", "organism": "Mouse", "refseq_name": "cytoplasmic tRNA 2-thiolation protein 2", "refseq_ac": [ { "id": "NP_722470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722470", "type": "external" } ], "gene_names_uniprotkb": "Ctu2; CTU2; NCS2; Ncs2", "gene_names_refseq": "2310061F22Rik; C16orf84; Ctu2; Ncs2", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 2", "protein_names_refseq": "cytoplasmic tRNA 2-thiolation protein 2; cytosolic thiouridylase subunit 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66965)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19017811;21750661;28135057;28528544;34428180", "class_list": "", "function": "Identifies an homologous human protein that plays a role in tRNA modification., [RefSeq, PubMed]; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTG9;Q8CI68", "ec_number_list": [], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3U308-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Z4-1", "uniprot_id": [ { "id": "CERS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924Z4", "type": "external" } ], "mass": 45024.0, "length": 380, "protein_name": "Ceramide synthase 2", "gene_name": "Cers2", "organism": "Mouse", "refseq_name": "ceramide synthase 2", "refseq_ac": [ { "id": "NP_001307421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307421", "type": "external" } ], "gene_names_uniprotkb": "Cers2; Lass2; Trh3", "gene_names_refseq": "0610013I17Rik; Cers2; Lass2; TRH3", "protein_names_uniprotkb": "Ceramide synthase 2; 2.3.1.24; 2.3.1.297; CerS2; LAG1 longevity assurance homolog 2; Sphingosine N-acyltransferase CERS2; TRAM homolog 3; Translocating chain-associating membrane protein homolog 3; Tumor metastasis-suppressor gene 1 protein; Very-long-chain ceramide synthase CERS2", "protein_names_refseq": "LAG1 homolog, ceramide synthase 2; LAG1 longevity assurance homolog 2; TRAM homolog 3; ceramide synthase 2; sphingosine N-acyltransferase CERS2; translocating chain-associating membrane protein homolog 3; tumor metastasis-suppressor gene 1 protein; very-long-chain ceramide synthase CERS2", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:76893); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;15823095;18165233;19801672;20110363;21183079;21750661;22872234;23275342;25428506;26495903;26620563;30899004;31219806;31616917;32279995;34428180;36210013;36946034;38961186", "class_list": "glycogene", "function": "Activity of CerS2 can be regulated by another bioactive sphingolipid, sphingosine 1-phosphate, [RefSeq, PubMed]; Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:15823095, PubMed:18165233, PubMed:20110363, PubMed:23275342, PubMed:38961186). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:15823095, PubMed:18165233, PubMed:20110363, PubMed:23275342). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (PubMed:19801672, PubMed:32279995)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas., [RefSeq, PubMed]; [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXC5;Q9DCN6", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.299", "type": "external" }, { "id": "2.3.1.298", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.298", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.291", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.291", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0016410 N-acyltransferase activity;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0019216 regulation of lipid metabolic process;GO:0030148 sphingolipid biosynthetic process;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q924Z4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH53-1", "uniprot_id": [ { "id": "CFA69_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH53", "type": "external" } ], "mass": 106233.0, "length": 942, "protein_name": "Cilia- and flagella-associated protein 69", "gene_name": "Cfap69", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 69", "refseq_ac": [ { "id": "NP_766035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766035", "type": "external" } ], "gene_names_uniprotkb": "Cfap69; A330021E22Rik", "gene_names_refseq": "4921525K03; A330021E22Rik; Cfap69", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 69", "protein_names_refseq": "cilia- and flagella-associated protein 69", "tax_id": 10090, "disease": "spermatogenic failure 24 (Disease Ontology:DOID:0111929)", "pathway": " (mmu:207686)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;21750661;28495971;29606301;30415212;34428180", "class_list": "", "function": "A330021E22Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; CFAP69 is necessary for flagellum assembly/stability and that in both humans and mice, [RefSeq, PubMed]; Cilium- and flagellum-associated protein (PubMed:28495971, PubMed:29606301). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (PubMed:28495971). Required for sperm flagellum assembly and stability (PubMed:29606301)., [UniProtKB, PubMed, PubMed]; Homozygous loss-of-function mutations of CFAP69 are associated with abnormalities of the sperm flagella and severe asthenoteratospermia., [RefSeq, PubMed]; Therefore, the role of CFAP69 in the olfactory system seems to be to allow the olfactory transduction machinery to work at a precisely regulated range of response kinetics for robust olfactory behavior.SIGNIFICANCE STATEMENT Sensory receptor cells are generally thought to evolve to respond to sensory cues as fast as they can., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPR3;Q8CA81;Q8CDU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097730 non-motile cilium;GO:0097225 sperm midpiece;GO:1990718 axonemal central pair projection", "go_biological_process": "GO:0042048 olfactory behavior;GO:0030317 flagellated sperm motility;GO:0007608 sensory perception of smell;GO:0007288 sperm axoneme assembly;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BH53-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61418-1", "uniprot_id": [ { "id": "CLCN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61418", "type": "external" } ], "mass": 83733.0, "length": 747, "protein_name": "H(+)/Cl(-) exchange transporter 4", "gene_name": "Clcn4", "organism": "Mouse", "refseq_name": "H(+)/Cl(-) exchange transporter 4 isoform 1", "refseq_ac": [ { "id": "NP_035464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035464", "type": "external" } ], "gene_names_uniprotkb": "Clcn4; Clc4; Clcn4-2", "gene_names_refseq": "Clc4-2; Clcn4-2; Clcn4; clC-4", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; Chloride transporter ClC-4; ClC-4", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 4 isoform 1; chloride channel 4-2; chloride channel protein 4; chloride transporter ClC-4; h(+)/Cl(-) exchange transporter 4; voltage-gated chloride channel ClC-4A", "tax_id": 10090, "disease": "Dent disease (Disease Ontology:DOID:0050699); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); Raynaud-Claes syndrome (Disease Ontology:DOID:0112060); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (mmu:12727); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17023393;21750661;25605945;32118314;7670496", "class_list": "", "function": "Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2TAX6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006821 chloride transport;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61418-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61147-1", "uniprot_id": [ { "id": "CERU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61147", "type": "external" } ], "mass": 121151.0, "length": 1061, "protein_name": "Ceruloplasmin", "gene_name": "Cp", "organism": "Mouse", "refseq_name": "ceruloplasmin isoform c precursor", "refseq_ac": [ { "id": "NP_001263177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263177", "type": "external" } ], "gene_names_uniprotkb": "Cp", "gene_names_refseq": "Cp; D3Ertd555e", "protein_names_uniprotkb": "Ceruloplasmin; 1.11.1.27; 1.11.1.9; 1.16.3.1; 1.16.3.4; Cuproxidase ceruloplasmin; Ferroxidase ceruloplasmin; Glutathione peroxidase ceruloplasmin; Glutathione-dependent peroxiredoxin ceruloplasmin", "protein_names_refseq": "ceruloplasmin isoform c precursor; cuproxidase ceruloplasmin; ferroxidase ceruloplasmin; ferroxidase; glutathione peroxidase ceruloplasmin; glutathione-dependent peroxiredoxin ceruloplasmin", "tax_id": 10090, "disease": "aceruloplasminemia (Disease Ontology:DOID:0050711); heart disease (Disease Ontology:DOID:114); hemosiderosis (Disease Ontology:DOID:12119); cholestasis (Disease Ontology:DOID:13580); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); systemic scleroderma (Disease Ontology:DOID:418); brain edema (Disease Ontology:DOID:4724); hyperthyroidism (Disease Ontology:DOID:7998); Wilson disease (Disease Ontology:DOID:893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12870); (R-MMU-381426); (R-MMU-425410); (R-MMU-8957275); (R-MMU-917937)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15365174;16906150;16944957;17330941;178338;20571061;21750661;23306200;25605945;26495903;26740625;29183916;343622;34428180;34887587;37507081;37828378;39627609;39927985;8690795", "class_list": "", "function": "Ceruloplasmin ane hephaestin are critical for CNS iron homeostasis and that loss of Cp and Heph in the mouse leads to age-dependent retinal neurodegeneration., [RefSeq, PubMed]; Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein (By similarity). It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species (By similarity). It is involved in iron transport across the cell membrane (By similarity). Copper ions provide a large number of enzymatic activites (By similarity). Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (By similarity). Acts as an inhibitor of the peroxidase activity of MPO (PubMed:23306200). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:29183916)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The mouse ceruloplasmin gene has been mapped to chromosome 3., [RefSeq, PubMed]; The mouse ceruloplasmin gene has been mapped to chromosome 3. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5C8", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001889 liver development;GO:0006878 intracellular copper ion homeostasis;GO:0006954 inflammatory response;GO:0006879 intracellular iron ion homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q61147-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62192-1", "uniprot_id": [ { "id": "CD180_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62192", "type": "external" } ], "mass": 74302.0, "length": 661, "protein_name": "CD180 antigen", "gene_name": "Cd180", "organism": "Mouse", "refseq_name": "CD180 antigen isoform 1 precursor", "refseq_ac": [ { "id": "NP_032559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032559", "type": "external" } ], "gene_names_uniprotkb": "Cd180; Ly78; Rp105", "gene_names_refseq": "Cd180; F630107B15; Ly-78; Ly78; RP105", "protein_names_uniprotkb": "CD180 antigen; Ly-78; Lymphocyte antigen 78; Radioprotective 105 kDa protein", "protein_names_refseq": "CD180 antigen isoform 1 precursor; lymphocyte antigen 78; radioprotective 105 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:17079); (R-MMU-166016)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10880523;15905547;21750661;21959264;26740625;30899004;34428180;35696803;36370035;39627609;7897216;9686597", "class_list": "", "function": "Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis., [RefSeq, PubMed]; Pattern recognition receptor predominantly expressed on B-cells, dendritic cells, and certain monocytes/macrophages, structurally resembling Toll-like receptors (TLRs) that plays a role in modulating immune responses. While ressembling a TLR, lacks the intracellular TIR (Toll/IL-1R) signaling domain and thus does not directly transduce signals. Instead, modulates immune responses, often in conjunction with other TLRs. For example, in cooperation with MD-1/LY86, interacts directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligand., [UniProtKB, PubMed, UniProtKB]; RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-kappaB signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8C251", "ec_number_list": [], "go_molecular_function": "GO:0001875 lipopolysaccharide immune receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0072686 mitotic spindle", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0071222 cellular response to lipopolysaccharide;GO:0002322 B cell proliferation involved in immune response;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q62192-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88545-1", "uniprot_id": [ { "id": "CSN6_MOUSE", "url": "https://www.uniprot.org/uniprot/O88545", "type": "external" } ], "mass": 35880.0, "length": 324, "protein_name": "COP9 signalosome complex subunit 6", "gene_name": "Cops6", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 6", "refseq_ac": [ { "id": "NP_036132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036132", "type": "external" } ], "gene_names_uniprotkb": "Cops6; Csn6", "gene_names_refseq": "Cops6; Sgn3; VIP/MOV34", "protein_names_uniprotkb": "COP9 signalosome complex subunit 6; JAB1-containing signalosome subunit 6; SGN6; Signalosome subunit 6", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 6; COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6; COP9 signalosome complex subunit 6; JAB1-containing signalosome subunit 6; SGN6; signalosome subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:26893); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "20173027;21750661;25428506;25605945;29991022;30084848;30779550;32882218;34203471;34428180;9707402", "class_list": "", "function": "CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2., [RefSeq, PubMed]; CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis., [RefSeq, PubMed]; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88545-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D131-1", "uniprot_id": [ { "id": "CFA68_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D131", "type": "external" } ], "mass": 19527.0, "length": 166, "protein_name": "Cilia- and flagella-associated protein 68", "gene_name": "Cfap68", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 68 isoform 2", "refseq_ac": [ { "id": "NP_001298002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298002", "type": "external" } ], "gene_names_uniprotkb": "Cfap68; 1110032A03Rik", "gene_names_refseq": "1110032A03Rik; 4930500N06Rik; Cfap68; c11orf1", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 68", "protein_names_refseq": "UPF0686 protein C11orf1 homolog; cilia- and flagella-associated protein 68 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68721)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10873569;21750661;37295417", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM17;Q3TYP3;Q4FK47;Q8K0A6;Q9D589;Q9JHT0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54833-1", "uniprot_id": [ { "id": "CSK22_MOUSE", "url": "https://www.uniprot.org/uniprot/O54833", "type": "external" } ], "mass": 41215.0, "length": 350, "protein_name": "Casein kinase II subunit alpha'", "gene_name": "Csnk2a2", "organism": "Mouse", "refseq_name": "casein kinase II subunit alpha'", "refseq_ac": [ { "id": "NP_034104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034104", "type": "external" } ], "gene_names_uniprotkb": "Csnk2a2", "gene_names_refseq": "1110035J23Rik; CK2; Csnk2a2", "protein_names_uniprotkb": "Casein kinase II subunit alpha'; 2.7.11.1; CK II alpha'", "protein_names_refseq": "CK II alpha'; casein kinase II subunit alpha'; casein kinase II, alpha 2, polypeptide", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:13000); (R-MMU-1483191); (R-MMU-201688); (R-MMU-2514853); (R-MMU-445144); (R-MMU-6804756); (R-MMU-6814122); (R-MMU-8934903); (R-MMU-8939243); (R-MMU-8948751); (R-MMU-9768727); (R-MMU-9929491)", "pathway_count": 12, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10471512;19273531;21750661;22517741;22645316;28355567;32848054;33300544;34203471;34428180;38494129;38503901;9503019;9694889", "class_list": "", "function": "CK2 activity is crucial for proper glucagon expression., [RefSeq, PubMed]; CK2 negatively regulates the extinction of remote fear memory., [RefSeq, PubMed]; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001669 acrosomal vesicle;GO:0000785 chromatin;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O54833-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KN2-1", "uniprot_id": [ { "id": "CIAO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KN2", "type": "external" } ], "mass": 37633.0, "length": 339, "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "Ciao1", "organism": "Mouse", "refseq_name": "probable cytosolic iron-sulfur protein assembly protein CIAO1", "refseq_ac": [ { "id": "NP_079572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079572", "type": "external" } ], "gene_names_uniprotkb": "Ciao1; Wdr39", "gene_names_refseq": "Ciao1; Wdr39", "protein_names_uniprotkb": "Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39", "protein_names_refseq": "WD repeat domain 39; WD repeat-containing protein 39; WD40 protein Ciao1; cytosolic iron-sulfur protein assembly 1 homolog; probable cytosolic iron-sulfur protein assembly protein CIAO1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26371)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23891004;25428506;34428180", "class_list": "", "function": "Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCZ7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005737 cytoplasm;GO:0071817 MMXD complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99KN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3G9-1", "uniprot_id": [ { "id": "DP13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3G9", "type": "external" } ], "mass": 73854.0, "length": 662, "protein_name": "DCC-interacting protein 13-beta", "gene_name": "Appl2", "organism": "Mouse", "refseq_name": "DCC-interacting protein 13-beta", "refseq_ac": [ { "id": "NP_660255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660255", "type": "external" } ], "gene_names_uniprotkb": "Appl2; Dip13b; Dip3b", "gene_names_refseq": "Appl2; DIP13 beta; Dip3 beta; Dip3b", "protein_names_uniprotkb": "DCC-interacting protein 13-beta; Adapter protein containing PH domain, PTB domain and leucine zipper motif 2; Dip13-beta", "protein_names_refseq": "DCC-interacting protein 13-beta; adapter protein containing PH domain, PTB domain and leucine zipper motif 2; dip13-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:216190)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "19661063;21750661;24879834;25328665;25568335;26445298;27219021;28965332;29467283;29675572;31219806;33122440;34162682;34428180;36210013", "class_list": "", "function": "Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration., [RefSeq, PubMed]; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:19661063, PubMed:25328665, PubMed:25568335, PubMed:27219021, PubMed:29467283). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses (PubMed:25328665, PubMed:25568335, PubMed:27219021). In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling (PubMed:25568335). In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines (PubMed:27219021). Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (PubMed:25328665). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (By similarity). Plays a role in cell metabolism by regulating adiponectin and insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:19661063, PubMed:29467283). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (PubMed:19661063). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (By similarity). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (PubMed:29467283). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:26445298, PubMed:28965332, PubMed:29675572). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor (PubMed:28965332, PubMed:29675572). Required for fibroblast migration through HGF cell signaling (PubMed:26445298)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic beta-cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LT7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0008283 cell population proliferation;GO:0046322 negative regulation of fatty acid oxidation;GO:0051289 protein homotetramerization;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K3G9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VN0-1", "uniprot_id": [ { "id": "CP100_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VN0", "type": "external" } ], "mass": 72033.0, "length": 613, "protein_name": "Cilia- and flagella-associated protein 100", "gene_name": "Cfap100", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 100", "refseq_ac": [ { "id": "NP_776136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776136", "type": "external" } ], "gene_names_uniprotkb": "Cfap100; Ccdc37", "gene_names_refseq": "C030041G11Rik; C230069K22Rik; Ccdc37; Cfap100", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 100; Coiled-coil domain-containing protein 37", "protein_names_refseq": "cilia- and flagella-associated protein 100; coiled-coil domain containing 37; coiled-coil domain-containing protein 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:243538)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40593606", "class_list": "", "function": "Microtubule-associated protein that promotes microtubule polymerization and regulates microtubule organization (By similarity). Plays a critical role in ensuring proper epidermal development and function by regulating mitosis in keratinocytes (PubMed:40593606). Maintains spindle pole integrity during keratinocyte division through the recruitment of the microtubule glutamylase TTLL13 to spindle poles, thereby enhancing localized microtubule glutamylation (PubMed:40593606). This modification stabilizes spindle microtubules, ensuring accurate spindle assembly, faithful chromosome segregation, and efficient mitotic progression (PubMed:40593606). May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PYA2;Q6AXD6", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0036064 ciliary basal body;GO:0097545 axonemal doublet microtubule;GO:0005856 cytoskeleton;GO:0005929 cilium", "go_biological_process": "GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88668-1", "uniprot_id": [ { "id": "CREG1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88668", "type": "external" } ], "mass": 24452.0, "length": 220, "protein_name": "Protein CREG1", "gene_name": "Creg1", "organism": "Mouse", "refseq_name": "protein CREG1 precursor", "refseq_ac": [ { "id": "NP_035934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035934", "type": "external" } ], "gene_names_uniprotkb": "Creg1; Creg", "gene_names_refseq": "Creg1; Creg", "protein_names_uniprotkb": "Protein CREG1; Cellular repressor of E1A-stimulated genes 1", "protein_names_refseq": "protein CREG1 precursor; protein CREG1", "tax_id": 10090, "disease": "", "pathway": " (mmu:433375); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10815803;11801660;16075062;18621046;21750661;30059200;30899004;32152506;36528955;37402034;37496998;37507081;37658156;37828378;38272853;9710587", "class_list": "", "function": "CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway., [RefSeq, PubMed]; CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration., [RefSeq, PubMed]; CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells., [RefSeq, PubMed]; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity)., [UniProtKB]; Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes., [RefSeq, PubMed]; The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes., [RefSeq, PubMed]; The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNP8;Q8C3I1", "ec_number_list": [], "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005764 lysosome;GO:0005667 transcription regulator complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006897 endocytosis;GO:0006355 regulation of DNA-templated transcription;GO:0006914 autophagy;GO:0007040 lysosome organization;GO:0007042 lysosomal lumen acidification", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O88668-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC8-1", "uniprot_id": [ { "id": "S26A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVC8", "type": "external" } ], "mass": 83590.0, "length": 757, "protein_name": "Chloride anion exchanger", "gene_name": "Slc26a3", "organism": "Mouse", "refseq_name": "chloride anion exchanger", "refseq_ac": [ { "id": "NP_067328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067328", "type": "external" } ], "gene_names_uniprotkb": "Slc26a3; Dra", "gene_names_refseq": "9030623B18Rik; 9130013M11Rik; Dra; Slc26a3", "protein_names_uniprotkb": "Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3", "protein_names_refseq": "chloride anion exchanger; down-regulated in adenoma", "tax_id": 10090, "disease": "congenital secretory chloride diarrhea 1 (Disease Ontology:DOID:0060296); diarrhea (Disease Ontology:DOID:13250)", "pathway": " (mmu:13487); (R-MMU-427601)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10428871;16901991;21750661;21976599;22627094;30084848;34428180;36535508;37350393;38829391", "class_list": "glycogene", "function": "In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts., [RefSeq, PubMed]; Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection., [RefSeq, PubMed]; Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk., [RefSeq, PubMed]; Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:10428871). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:21976599)., [UniProtKB, PubMed, PubMed]; The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine., [RefSeq, PubMed]; This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RTD9", "ec_number_list": [], "go_molecular_function": "GO:0015106 bicarbonate transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0048240 sperm capacitation;GO:1902476 chloride transmembrane transport;GO:0060081 membrane hyperpolarization;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVC8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54751-1", "uniprot_id": [ { "id": "CRX_MOUSE", "url": "https://www.uniprot.org/uniprot/O54751", "type": "external" } ], "mass": 32374.0, "length": 299, "protein_name": "Cone-rod homeobox protein", "gene_name": "Crx", "organism": "Mouse", "refseq_name": "cone-rod homeobox protein isoform 2", "refseq_ac": [ { "id": "NP_001106801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106801", "type": "external" } ], "gene_names_uniprotkb": "Crx", "gene_names_refseq": "Crx1; Crx", "protein_names_uniprotkb": "Cone-rod homeobox protein", "protein_names_refseq": "cone-rod homeobox containing; cone-rod homeobox protein isoform 2; cone-rod homeobox protein", "tax_id": 10090, "disease": "Leber congenital amaurosis 7 (Disease Ontology:DOID:0110333); cone-rod dystrophy 2 (Disease Ontology:DOID:0111005); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:12951)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16574740;21750661;38355306;9390562", "class_list": "", "function": "Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0046534 positive regulation of photoreceptor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54751-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08091-1", "uniprot_id": [ { "id": "CNN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08091", "type": "external" } ], "mass": 33356.0, "length": 297, "protein_name": "Calponin-1", "gene_name": "Cnn1", "organism": "Mouse", "refseq_name": "calponin-1", "refseq_ac": [ { "id": "NP_034052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034052", "type": "external" } ], "gene_names_uniprotkb": "Cnn1", "gene_names_refseq": "CN; Cnn1; CnnI", "protein_names_uniprotkb": "Calponin-1; Basic calponin; Calponin H1, smooth muscle", "protein_names_refseq": "basic calponin; calponin H1, smooth muscle; calponin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12797)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;26495903;30084848;8370452;8550594", "class_list": "", "function": "Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9859, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0031032 actomyosin structure organization;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08091-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQ48-1", "uniprot_id": [ { "id": "CE295_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQ48", "type": "external" } ], "mass": 272779.0, "length": 2412, "protein_name": "Centrosomal protein of 295 kDa", "gene_name": "Cep295", "organism": "Mouse", "refseq_name": "centrosomal protein of 295 kDa", "refseq_ac": [ { "id": "NP_795950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795950", "type": "external" } ], "gene_names_uniprotkb": "Cep295; 5830418K08Rik; Kiaa1731", "gene_names_refseq": "5830418K08Rik; 5832426L23Rik; Cep295; Gm1131; Kiaa1731", "protein_names_uniprotkb": "Centrosomal protein of 295 kDa", "protein_names_refseq": "centrosomal protein of 295 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:319675)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;34678516", "class_list": "", "function": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule. May be involved in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF60;Q3UYP6;Q571B9;Q8CCJ2;Q8CDA9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:1904951 positive regulation of establishment of protein localization;GO:0030030 cell projection organization;GO:0046599 regulation of centriole replication;GO:1903724 positive regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BQ48-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35864-1", "uniprot_id": [ { "id": "CSN5_MOUSE", "url": "https://www.uniprot.org/uniprot/O35864", "type": "external" } ], "mass": 37549.0, "length": 334, "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "Cops5", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 5 isoform 2", "refseq_ac": [ { "id": "NP_001264030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264030", "type": "external" } ], "gene_names_uniprotkb": "Cops5; Csn5; Jab1; Kic2", "gene_names_refseq": "CSN5; Cops5; Jab1; Mov34; Sgn5", "protein_names_uniprotkb": "COP9 signalosome complex subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; Kip1 C-terminus-interacting protein 2; SGN5; Signalosome subunit 5", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 complex S5; COP9 signalosome complex subunit 5 isoform 2; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:26754); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664); (R-MMU-9929356)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10086358;10721695;11707426;15082527;15451666;21750661;22872234;25428506;28315936;30084848;30779550;31219806;31599954;34428180;34874913;37067025;9341143;9707402", "class_list": "", "function": "Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice., [RefSeq, PubMed]; JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice., [RefSeq, PubMed]; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA70;Q8C1S1", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0035718 macrophage migration inhibitory factor binding;GO:0003713 transcription coactivator activity;GO:0008237 metallopeptidase activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:1990182 exosomal secretion;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35864-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZI0-1", "uniprot_id": [ { "id": "CELR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZI0", "type": "external" } ], "mass": 358478.0, "length": 3301, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 3", "gene_name": "Celsr3", "organism": "Mouse", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 3 isoform 3 precursor", "refseq_ac": [ { "id": "NP_536685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536685", "type": "external" } ], "gene_names_uniprotkb": "Celsr3", "gene_names_refseq": "Adgrc3; Celsr3; Fmi1; flamingo; mKIAA0812", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 3", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 3 isoform 3 precursor; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)", "tax_id": 10090, "disease": "", "pathway": " (mmu:107934)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10790539;11677057;11850187;11891983;21750661;31219806;34418053", "class_list": "", "function": "Developmental expression profiles of Celsr (Flamingo) genes in the mouse, [RefSeq, PubMed]; Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development, [RefSeq, PubMed]; Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 9, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "E9QLD7;Q9ESD0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0097475 motor neuron migration;GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q91ZI0-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C963-1", "uniprot_id": [ { "id": "CC159_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C963", "type": "external" } ], "mass": 46342.0, "length": 411, "protein_name": "Coiled-coil domain-containing protein 159", "gene_name": "Ccdc159", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 159 isoform 1", "refseq_ac": [ { "id": "NP_001158086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158086", "type": "external" } ], "gene_names_uniprotkb": "Ccdc159", "gene_names_refseq": "2510048L02Rik; Ccdc159", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 159", "protein_names_refseq": "coiled-coil domain-containing protein 159 isoform 1; coiled-coil domain-containing protein 159", "tax_id": 10090, "disease": "male infertility due to acephalic spermatozoa (Disease Ontology:DOID:0112311)", "pathway": " (mmu:67119)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;38236177", "class_list": "", "function": "Functions during spermatid development; may participate in the centrosome reduction procedure of spermatids and is required for the formation of the connecting piece/sperm head-tail coupling apparatus (HTCA) and the correct and tight attachment of the flagellum to the nuclear envelope., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBB7;Q9CXZ5;Q9D4W5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0010921 regulation of phosphatase activity;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C963-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZB0-1", "uniprot_id": [ { "id": "DNJC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZB0", "type": "external" } ], "mass": 29813.0, "length": 253, "protein_name": "DnaJ homolog subfamily C member 8", "gene_name": "Dnajc8", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 8", "refseq_ac": [ { "id": "NP_765988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765988", "type": "external" } ], "gene_names_uniprotkb": "Dnajc8", "gene_names_refseq": "1110021D09Rik; 2010009J04Rik; Dnajc8", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 8", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 8; dnaJ homolog subfamily C member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:68598); (R-MMU-9770562)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG72;Q8C2M6", "ec_number_list": [], "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NZB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT23-1", "uniprot_id": [ { "id": "DAAF9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT23", "type": "external" } ], "mass": 132207.0, "length": 1179, "protein_name": "Dynein axonemal assembly factor 9", "gene_name": "Dnaaf9", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 9 isoform 1", "refseq_ac": [ { "id": "NP_083708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083708", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf9; 4930402H24Rik", "gene_names_refseq": "2810487F15Rik; 4930402H24Rik; Dnaaf9", "protein_names_uniprotkb": "Dynein axonemal assembly factor 9; DNAAF9; Shulin", "protein_names_refseq": "dynein axonemal assembly factor 9 isoform 1; shulin; uncharacterized protein C20orf194 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:228602)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;31219806;34203471;34428180;36210013;40885482", "class_list": "", "function": "Dynein axonemal assembly factor that regulates the transport and activation of ciliary outer dynein arms (ODAs), which are the main force generators in cilia (By similarity). Essential for cilia movement and motility (By similarity). Inhibits dyneins by reducing the affinity of ODAs for microtubules and hence inactivating the dyneins in the cytoplasm; the inhibition is relieved once dyneins enter the cilia (By similarity). May act as an effector for ARL3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPD4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TT23-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X79-1", "uniprot_id": [ { "id": "CELA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X79", "type": "external" } ], "mass": 28901.0, "length": 266, "protein_name": "Chymotrypsin-like elastase family member 1", "gene_name": "Cela1", "organism": "Mouse", "refseq_name": "chymotrypsin-like elastase family member 1 precursor", "refseq_ac": [ { "id": "NP_291090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291090", "type": "external" } ], "gene_names_uniprotkb": "Cela1; Ela1", "gene_names_refseq": "1810009A17Rik; 1810062B19Rik; Cela1; Ela-1; Ela1; PC-TsF", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 1; 3.4.21.36; Elastase-1", "protein_names_refseq": "chymotrypsin-like elastase family member 1 precursor; elastase 1, pancreatic; elastase-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109901)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26495903;3493908;35749514", "class_list": "", "function": "Serine proteases that hydrolyze many proteins in addition to elastin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D936;Q9Z1H1", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91X79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBE0-1", "uniprot_id": [ { "id": "CSAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBE0", "type": "external" } ], "mass": 55145.0, "length": 493, "protein_name": "Cysteine sulfinic acid decarboxylase", "gene_name": "Csad", "organism": "Mouse", "refseq_name": "cysteine sulfinic acid decarboxylase isoform 1", "refseq_ac": [ { "id": "NP_659191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659191", "type": "external" } ], "gene_names_uniprotkb": "Csad", "gene_names_refseq": "Csad; Csd", "protein_names_uniprotkb": "Cysteine sulfinic acid decarboxylase; 4.1.1.11; 4.1.1.29; Aspartate 1-decarboxylase; Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase", "protein_names_refseq": "aspartate 1-decarboxylase; cysteine sulfinic acid decarboxylase isoform 1; cysteine-sulfinate decarboxylase; sulfinoalanine decarboxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:246277)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11997111;16252094;21750661;25394658;25428506;26327310;30084848;31599954;34428180;36555571;37453647;37507081", "class_list": "", "function": "CDNA sequence that predicts a polypeptide of 493 amino acids - both sequences given, [RefSeq, PubMed]; CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate., [UniProtKB, PubMed]; Estradiol decreases taurine concentration mainly via the reduction of cysteine sulfinic acid decarboxylase expression level through the ER-alpha., [RefSeq, PubMed]; Taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1), [RefSeq, PubMed]; The results show that CSD is expressed both at the mRNA and protein levels in the testis, epididymis and ductus deferens., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K566", "ec_number_list": [ { "id": "4.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.29", "type": "external" }, { "id": "4.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004782 sulfinoalanine decarboxylase activity;GO:0004068 aspartate 1-decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042412 taurine biosynthetic process;GO:0019449 L-cysteine catabolic process to hypotaurine;GO:0019530 taurine metabolic process;GO:0019452 L-cysteine catabolic process to taurine;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DBE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAR1-1", "uniprot_id": [ { "id": "CLF2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAR1", "type": "external" } ], "mass": 19553.0, "length": 169, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 2A", "gene_name": "Cmtm2a", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 2A", "refseq_ac": [ { "id": "NP_081298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081298", "type": "external" } ], "gene_names_uniprotkb": "Cmtm2a; Cklfsf2a", "gene_names_refseq": "1700001K04Rik; 1700041N15Rik; 1700063K20Rik; ARR19; C32; CKLF3; CKLF4; CKLF5; Cklf1; Cklfsf2-1b; Cklfsf2a; Cklf; Cmtm2a; UCK-1", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 2A; Chemokine-like factor superfamily member 2A", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 2A; chemokine-like factor super family 2A; chemokine-like factor superfamily 2-1b; chemokine-like factor superfamily member 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73381)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12183067;14576337;14672409;16343975;21750661;25428506;26260329;30209135;30982091;37098609", "class_list": "", "function": "A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]; ARR19 may act as an androgen receptor corepressor in vivo and play an important role in male reproductive functions, [RefSeq, PubMed]; CKLF1 is an important mediator that skewing microglia/macrophage toward M1 phenotype at early stage of cerebral ischemic injury Erratum:[Cell Mol Neurobiol. 2024 May 10;44(1):45. doi: 10.1007/s10571-024-01480-7. PMID: 38727836], [RefSeq, PubMed]; Co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm fertilizing ability. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that mouse Cklfsf2a and Cklfsf2b are two homologues of human CKLFSF2., [RefSeq, PubMed]; Overexpression of chemokine-like factor 2 promotes the proliferation and survival of C2C12 skeletal muscle cells., [RefSeq, PubMed]; Results show that mouse chemokine-like factors (CKLF) 2, 4, 5 and 6 are four splicing variants which are homologues of human CKLFs, and that murine CKLFs possess distinct features compared to their human counterparts., [RefSeq, PubMed]; Taken together, these results suggest that ARR19 may play an important role in the differentiation of male reproductive organs such as testis and prostate Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811V3;Q9CVR4", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0045892 negative regulation of DNA-templated transcription;GO:2000224 regulation of testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DAR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZE1-1", "uniprot_id": [ { "id": "DMBTL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZE1", "type": "external" } ], "mass": 90689.0, "length": 841, "protein_name": "Putative DMBT1-like protein", "gene_name": "Cdcp3", "organism": "Mouse", "refseq_name": "putative DMBT1-like protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_780375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780375", "type": "external" } ], "gene_names_uniprotkb": "Cdcp3; 5430419D17Rik", "gene_names_refseq": "5430419D17Rik; Cdcp3", "protein_names_uniprotkb": "Putative DMBT1-like protein", "protein_names_refseq": "putative DMBT1-like protein isoform 1 precursor; putative DMBT1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71395)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QN00", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61712-1", "uniprot_id": [ { "id": "DNJC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61712", "type": "external" } ], "mass": 63870.0, "length": 552, "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "Dnajc1", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 1 precursor", "refseq_ac": [ { "id": "NP_001177746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177746", "type": "external" } ], "gene_names_uniprotkb": "Dnajc1; Dnajl1; Mtj1", "gene_names_refseq": "4733401K02Rik; D230036H06Rik; Dnajc1; Dnajl1; ERdj1; ERj1p; MTJ1", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 1; DnaJ protein homolog MTJ1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 1; DnaJ-like protein 1; dnaJ homolog subfamily C member 1 precursor; dnaJ homolog subfamily C member 1; dnaJ protein homolog MTJ1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13418)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15699139;16244660;16244664;16271702;17242355;18213612;21183079;21750661;22837305;25428506;36210013;7875597", "class_list": "", "function": "Data suggest that vaspin is a ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 complex; subsequent signal transduction exerts beneficial effects on endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity., [RefSeq, PubMed]; ERj1p coordinates the ribosome at the membrane and allosteric effects may mediate ERj1p's regulatory activity, [RefSeq, PubMed]; ERj1p inhibits translation in the absence of BiP, and mediates binding of the nuclear import factor importin beta and import into the nucleus., [RefSeq, PubMed]; ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment, [RefSeq, PubMed]; In addition to assisting the chaperone GRP78 in protein quality control in the endoplasmic reticulum, MTJ-1 is essential for transport of GRP78 to the macrophage surface, which serves a number of functions in immune regulation and signal transduction., [RefSeq, PubMed]; May modulate protein synthesis., [UniProtKB]; Plasma membrane-associated GRP78 is coupled to pertussis toxin-insensitive Galphaq11 and forms a ternary signaling complex with MTJ-1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0051087 protein-folding chaperone binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0006457 protein folding;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CF31-1", "uniprot_id": [ { "id": "FREY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CF31", "type": "external" } ], "mass": 11064.0, "length": 99, "protein_name": "Protein Frey", "gene_name": "Frey1", "organism": "Mouse", "refseq_name": "protein Frey", "refseq_ac": [ { "id": "NP_898935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898935", "type": "external" } ], "gene_names_uniprotkb": "Frey1; 1700029I15Rik; Frey", "gene_names_refseq": "1700021K07Rik; 1700029I15Rik; Frey1; Frey", "protein_names_uniprotkb": "Protein Frey; FREY1; Frey regulator of sperm-oocyte fusion 1", "protein_names_refseq": "protein Frey; uncharacterized protein C11orf94 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75641)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35960805;36050562", "class_list": "", "function": "Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome (PubMed:35960805, PubMed:36050562). Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP (PubMed:35960805)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AHH2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CF31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSQ1-1", "uniprot_id": [ { "id": "CL18A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSQ1", "type": "external" } ], "mass": 58585.0, "length": 534, "protein_name": "C-type lectin domain family 18 member A", "gene_name": "Clec18a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 18 member A isoform X7", "refseq_ac": [ { "id": "XP_006531206", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006531206", "type": "external" } ], "gene_names_uniprotkb": "Clec18a; Mrcl; Mrlp", "gene_names_refseq": "Clec18a; Mrcl", "protein_names_uniprotkb": "C-type lectin domain family 18 member A; Mannose receptor-like protein", "protein_names_refseq": "C-type lectin domain family 18 member A isoform X7", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMA7;Q7TSP9;Q7TSQ0;Q7TSQ7", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TSQ1-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.1000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VAB4-1", "uniprot_id": [ { "id": "CNPY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VAB4", "type": "external" } ], "mass": 11249.0, "length": 94, "protein_name": "Protein canopy homolog 1", "gene_name": "Cnpy1", "organism": "Mouse", "refseq_name": "protein canopy homolog 1", "refseq_ac": [ { "id": "NP_001297440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297440", "type": "external" } ], "gene_names_uniprotkb": "Cnpy1", "gene_names_refseq": "1500012D20Rik; 9630008K15Rik; Canopy1; Cnpy1", "protein_names_uniprotkb": "Protein canopy homolog 1", "protein_names_refseq": "canopy 1 homolog; protein canopy homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBK9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VAB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZB2-1", "uniprot_id": [ { "id": "COAC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZB2", "type": "external" } ], "mass": 22344.0, "length": 204, "protein_name": "Phosphopantothenoylcysteine decarboxylase", "gene_name": "Ppcdc", "organism": "Mouse", "refseq_name": "phosphopantothenoylcysteine decarboxylase isoform a", "refseq_ac": [ { "id": "NP_789801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789801", "type": "external" } ], "gene_names_uniprotkb": "Ppcdc; Coac", "gene_names_refseq": "1810057I13Rik; 8430432M10Rik; Ppcdc", "protein_names_uniprotkb": "Phosphopantothenoylcysteine decarboxylase; 4.1.1.36; CoaC; PPC-DC", "protein_names_refseq": "PPC-DC; coaC; phosphopantothenoylcysteine decarboxylase isoform a", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:66812); (R-MMU-196783)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.36", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0010181 FMN binding;GO:0004633 phosphopantothenoylcysteine decarboxylase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0071513 phosphopantothenoylcysteine decarboxylase complex", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX13-1", "uniprot_id": [ { "id": "CNIH4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX13", "type": "external" } ], "mass": 16089.0, "length": 139, "protein_name": "Protein cornichon homolog 4", "gene_name": "Cnih4", "organism": "Mouse", "refseq_name": "protein cornichon homolog 4", "refseq_ac": [ { "id": "NP_084407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084407", "type": "external" } ], "gene_names_uniprotkb": "Cnih4", "gene_names_refseq": "CNIH-4; Cnih4; D530030D03Rik; E430023H19Rik; HSPC163", "protein_names_uniprotkb": "Protein cornichon homolog 4; CNIH-4; Cornichon family AMPA receptor auxiliary protein 4", "protein_names_refseq": "cornichon homolog 4; protein cornichon homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:98417)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16075062;21750661;36657507", "class_list": "", "function": "Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility., [RefSeq, PubMed]; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNM6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0031730 CCR5 chemokine receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CX13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG14-1", "uniprot_id": [ { "id": "CS1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG14", "type": "external" } ], "mass": 76858.0, "length": 688, "protein_name": "Complement C1s-1 subcomponent", "gene_name": "C1s1", "organism": "Mouse", "refseq_name": "complement C1s-1 subcomponent precursor", "refseq_ac": [ { "id": "NP_001091086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091086", "type": "external" } ], "gene_names_uniprotkb": "C1s1; C1sa; C1s", "gene_names_refseq": "C1s1; C1sa; C1s", "protein_names_uniprotkb": "Complement C1s-1 subcomponent; 3.4.21.42; C1 esterase; Complement C1s-A subcomponent; Complement component 1 subcomponent s-A; Complement component 1, S subcomponent 1", "protein_names_refseq": "C1 esterase; complement C1s-1 subcomponent precursor; complement C1s-1 subcomponent; complement C1s-A subcomponent; complement component 1 subcomponent s-A; complement component C1SA; serine protease", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome periodontal type 2 (Disease Ontology:DOID:0080987)", "pathway": " (mmu:50908)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12513694;21750661;26740625;37507081", "class_list": "", "function": "C1r and this gene are duplicated in mice; differential expression generates alternative isomorphs in the liver and in the male reproductive system., [RefSeq, PubMed]; Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJC4;Q8CH28;Q8VBY4", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005602 complement component C1 complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CG14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q355-1", "uniprot_id": [ { "id": "CTSG1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q355", "type": "external" } ], "mass": 132352.0, "length": 1151, "protein_name": "Cation channel sperm-associated protein subunit gamma 1", "gene_name": "Catsperg1", "organism": "Mouse", "refseq_name": "cation channel sperm-associated protein subunit gamma 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001158130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158130", "type": "external" } ], "gene_names_uniprotkb": "Catsperg1", "gene_names_refseq": "A230107C01Rik; Catsperg1; Catsperg", "protein_names_uniprotkb": "Cation channel sperm-associated protein subunit gamma 1", "protein_names_refseq": "cation channel sperm-associated protein subunit gamma 1 isoform 1 precursor; cation channel sperm-associated protein subunit gamma 1; cation channel, sperm-associated, gamma 1; catsper channel auxiliary subunit gamma 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320225); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19516020;21750661", "class_list": "", "function": "CATSPERG is predicted to be a single transmembrane-spanning protein with a large extracellular domain and a short intracellular tail., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PW02;E9QAY8;Q3V0A1;Q8C9D6;Q8CAA4;Q8R5F0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0031514 motile cilium;GO:0097228 sperm principal piece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q355-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58269-1", "uniprot_id": [ { "id": "DPF3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58269", "type": "external" } ], "mass": 43070.0, "length": 378, "protein_name": "Zinc finger protein DPF3", "gene_name": "Dpf3", "organism": "Mouse", "refseq_name": "zinc finger protein DPF3 isoform 1", "refseq_ac": [ { "id": "NP_001254554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254554", "type": "external" } ], "gene_names_uniprotkb": "Dpf3; Baf45c; Cerd4", "gene_names_refseq": "2810403B03Rik; 6530402L11Rik; BAF45C; CERD4; Dpf3; Gm18872; cer-d4", "protein_names_uniprotkb": "Zinc finger protein DPF3; BAF45C; BRG1-associated factor 45C; Zinc finger protein cer-d4", "protein_names_refseq": "BRG1-associated factor 45C; D4 zinc and double PHD finger family 3; cerebellum D4; zinc finger protein DPF3 isoform 1; zinc finger protein DPF3; zinc finger protein cer-d4", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:70127); (R-MMU-9933937)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11845289;17640523;18765789;21750661;31219806;32459350;34428180;8812431", "class_list": "", "function": "Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350)., [UniProtKB, PubMed]; HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription., [RefSeq, PubMed]; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W78;Q8CAD8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071565 nBAF complex;GO:0000785 chromatin", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P58269-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYS2-1", "uniprot_id": [ { "id": "CYBC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYS2", "type": "external" } ], "mass": 20921.0, "length": 187, "protein_name": "Cytochrome b-245 chaperone 1", "gene_name": "Cybc1", "organism": "Mouse", "refseq_name": "cytochrome b-245 chaperone 1 isoform 1", "refseq_ac": [ { "id": "NP_001239477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239477", "type": "external" } ], "gene_names_uniprotkb": "Cybc1; Eros", "gene_names_refseq": "Cybc1", "protein_names_uniprotkb": "Cytochrome b-245 chaperone 1; Eros; Essential for reactive oxygen species protein", "protein_names_refseq": "cytochrome b-245 chaperone 1 isoform 1; eros; essential for reactive oxygen species protein; uncharacterized protein C17orf62 homolog", "tax_id": 10090, "disease": "autosomal recessive chronic granulomatous disease 5 (Disease Ontology:DOID:0070368)", "pathway": " (mmu:217370)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22872234;28011936;28351984;30312704;31862710;34428180", "class_list": "", "function": "Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (PubMed:28351984)., [UniProtKB, UniProtKB, PubMed]; These results indicated that Eros acts as a chaperone not only for NADPH oxidase, but also for P2X7, and contributes to the innate immune reaction, [RefSeq, PubMed]; This study shows that the function of EROS is fully conserved between human and mouse, and that homozygous mutations in EROS underlie a novel sixth cause of chronic granulomatous disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AN24;A2AN25;Q8VD13", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0006816 calcium ion transport;GO:0006457 protein folding;GO:0045728 respiratory burst after phagocytosis;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TYS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZG3-1", "uniprot_id": [ { "id": "COMD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZG3", "type": "external" } ], "mass": 20852.0, "length": 183, "protein_name": "COMM domain-containing protein 8", "gene_name": "Commd8", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 8 isoform a", "refseq_ac": [ { "id": "NP_848714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848714", "type": "external" } ], "gene_names_uniprotkb": "Commd8", "gene_names_refseq": "Commd8; D5Buc26e", "protein_names_uniprotkb": "COMM domain-containing protein 8", "protein_names_refseq": "COMM domain-containing protein 8 isoform a; COMM domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:27784); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7F6", "ec_number_list": [], "go_molecular_function": "GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921L5-1", "uniprot_id": [ { "id": "COG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921L5", "type": "external" } ], "mass": 82040.0, "length": 731, "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "Cog2", "organism": "Mouse", "refseq_name": "conserved oligomeric Golgi complex subunit 2", "refseq_ac": [ { "id": "NP_084022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084022", "type": "external" } ], "gene_names_uniprotkb": "Cog2; Ldlc", "gene_names_refseq": "1190002B08Rik; 2700012E02Rik; Cog2; Ldlc", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein", "protein_names_refseq": "COG complex subunit 2; conserved oligomeric Golgi complex subunit 2; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIq (Disease Ontology:DOID:0070269)", "pathway": " (mmu:76332); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "Required for normal Golgi morphology and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF44;Q9CSQ1", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921L5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61362-1", "uniprot_id": [ { "id": "CH3L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61362", "type": "external" } ], "mass": 43893.0, "length": 389, "protein_name": "Chitinase-3-like protein 1", "gene_name": "Chi3l1", "organism": "Mouse", "refseq_name": "chitinase-3-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_031721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031721", "type": "external" } ], "gene_names_uniprotkb": "Chi3l1; Brp39; Chil1", "gene_names_refseq": "Brp39; Chi3l1; Chil1; Gp39", "protein_names_uniprotkb": "Chitinase-3-like protein 1; BRP39 protein; Breast regression protein 39; CGP-39; Cartilage glycoprotein 39; GP-39", "protein_names_refseq": "CGP-39; GP-39; YKL-40; breast regression protein 39; cartilage glycoprotein 39; chitinase-3-like protein 1 isoform 1 precursor; chitinase-3-like protein 1; chitinase-like 1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12654); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16472595;19041398;19414556;20558631;21546314;21750661;21866546;22817986;30084848;34428180;39150635;7970700", "class_list": "glycogene;glycosylhydrolase", "function": "Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and the hair cycle. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenic role in colitis, presumably by enhancing the adhesion and invasion of bacteria on/into colonic epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0FEU7;D3Z2P2;Q3U291;Q4FJW9;Q8BKL8;Q99J84", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006954 inflammatory response;GO:0034612 response to tumor necrosis factor;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61362-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C025-1", "uniprot_id": [ { "id": "CHPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C025", "type": "external" } ], "mass": 44608.0, "length": 398, "protein_name": "Cholinephosphotransferase 1", "gene_name": "Chpt1", "organism": "Mouse", "refseq_name": "cholinephosphotransferase 1 isoform 2", "refseq_ac": [ { "id": "NP_659056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659056", "type": "external" } ], "gene_names_uniprotkb": "Chpt1; Cpt1; Dn4", "gene_names_refseq": "Chpt1", "protein_names_uniprotkb": "Cholinephosphotransferase 1; 2.7.8.2; Diabetic nephropathy-associated gene transcript 1; Diacylglycerol cholinephosphotransferase 1; mCHPT1", "protein_names_refseq": "cholinephosphotransferase 1 isoform 2; diabetic nephropathy-associated gene transcript 1; diacylglycerol cholinephosphotransferase 1", "tax_id": 10090, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:212862); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15254874;21750661;34428180;37507081", "class_list": "", "function": "Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6SXV1;Q8K0H2;Q91W91", "ec_number_list": [ { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0006656 phosphatidylcholine biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C025-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIW6-1", "uniprot_id": [ { "id": "S26A6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIW6", "type": "external" } ], "mass": 82834.0, "length": 758, "protein_name": "Solute carrier family 26 member 6", "gene_name": "Slc26a6", "organism": "Mouse", "refseq_name": "solute carrier family 26 member 6 isoform 1", "refseq_ac": [ { "id": "NP_599252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599252", "type": "external" } ], "gene_names_uniprotkb": "Slc26a6; Cfex; Pat1", "gene_names_refseq": "B930010B04Rik; CFEX; Pat-1; Pat1; Slc26a6", "protein_names_uniprotkb": "Solute carrier family 26 member 6; Anion exchange transporter; Chloride-formate exchanger; Pat-1; Pendrin-L1; Pendrin-like protein 1; Putative anion transporter-1", "protein_names_refseq": "anion exchange transporter; chloride-formate exchanger; pendrin-L1; pendrin-like protein 1; putative anion transporter-1; solute carrier family 26 member 6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171429); (R-MMU-427601)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;11459928;11842009;12119287;12139400;12217875;15203903;16141316;16532010;16606687;17053783;17151144;17170027;18046080;18496516;20150244;20969732;21750661;21976599;22021714;22895259;23542070;23933580;27681177;29530983;33205229;35760786;35820727;36433745;38349781;38735402", "class_list": "glycogene", "function": "A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity, and Inflammation., [RefSeq, PubMed]; A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts., [RefSeq, PubMed]; A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes. Publication Status: Online-Only, [RefSeq, PubMed]; Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells., [RefSeq, PubMed]; An anion transporter expressed on the apical surface of renal proximal tubule cells and capable of mediating Cl(-)-formate exchange. Review article, [RefSeq, PubMed]; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Also mediates intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger also provides a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Also mediates the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Encodes an apical Cl(-)/formate/oxalate and Cl(-)/base exchanger and reveals significant mechanistic differences between apical and basolateral oxalate exchangers of the proximal tubule, [RefSeq, PubMed]; Mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2 (PubMed:12217875, PubMed:23933580). Also mediates exchange of chloride-formate and chloride-oxalate ions (PubMed:11459928, PubMed:12217875, PubMed:15203903, PubMed:17151144, PubMed:23933580). Mediates transcellular sulfate absorption (PubMed:12217875)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Mediates specificity of anion exchange, [RefSeq, PubMed]; The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate or chloride transport by mouse large intestine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 62, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q4D3;Q3TQD3;Q812E2;Q8CJD0;Q8K142;Q923J3", "ec_number_list": [], "go_molecular_function": "GO:0015499 formate transmembrane transporter activity;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0005254 chloride channel activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0015724 formate transport;GO:0015797 mannitol transmembrane transport;GO:0019532 oxalate transport;GO:0046724 oxalic acid secretion", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q8CIW6-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGB8-1", "uniprot_id": [ { "id": "COQ4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGB8", "type": "external" } ], "mass": 30084.0, "length": 266, "protein_name": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "gene_name": "Coq4", "organism": "Mouse", "refseq_name": "ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "refseq_ac": [ { "id": "NP_848808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848808", "type": "external" } ], "gene_names_uniprotkb": "Coq4", "gene_names_refseq": "Coq4; D2Ertd97e", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; 4.1.1.130; Coenzyme Q biosynthesis protein 4 homolog", "protein_names_refseq": "4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; coenzyme Q biosynthesis protein 4 homolog; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "tax_id": 10090, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); spastic ataxia (Disease Ontology:DOID:0050952); primary coenzyme Q10 deficiency 7 (Disease Ontology:DOID:0070244)", "pathway": " (mmu:227683); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11469793;21750661;30084848;31219806", "class_list": "", "function": "Homologous to the COQ4p in S. cerevisiae, a possible component of the biosynthetic complex for production of CoenzymeQ, or ubiquinone, [RefSeq, PubMed]; Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid into 2-methoxy-6-(all-trans-decaprenyl)phenol during ubiquinone biosynthesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016831 carboxy-lyase activity;GO:0120539 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35493-1", "uniprot_id": [ { "id": "CLK4_MOUSE", "url": "https://www.uniprot.org/uniprot/O35493", "type": "external" } ], "mass": 57345.0, "length": 481, "protein_name": "Dual specificity protein kinase CLK4", "gene_name": "Clk4", "organism": "Mouse", "refseq_name": "dual specificity protein kinase CLK4 isoform 2", "refseq_ac": [ { "id": "NP_001291673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291673", "type": "external" } ], "gene_names_uniprotkb": "Clk4", "gene_names_refseq": "Clk4", "protein_names_uniprotkb": "Dual specificity protein kinase CLK4; 2.7.12.1; CDC-like kinase 4", "protein_names_refseq": "dual specificity protein kinase CLK4 isoform 2; dual specificity protein kinase CLK4", "tax_id": 10090, "disease": "", "pathway": " (mmu:12750)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11461155;12169693;15010457;17242355;21183079;21750661;21949414;35907876;9307018;9339371", "class_list": "", "function": "CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins., [RefSeq, PubMed]; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35721;Q8CEU9;Q99LU6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation;GO:0046777 protein autophosphorylation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35493-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJF9-1", "uniprot_id": [ { "id": "CHM2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJF9", "type": "external" } ], "mass": 23935.0, "length": 213, "protein_name": "Charged multivesicular body protein 2b", "gene_name": "Chmp2b", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 2b", "refseq_ac": [ { "id": "NP_081155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081155", "type": "external" } ], "gene_names_uniprotkb": "Chmp2b", "gene_names_refseq": "1190006E07Rik; Chmp2b", "protein_names_uniprotkb": "Charged multivesicular body protein 2b; CHMP2b; Chromatin-modifying protein 2b", "protein_names_refseq": "charged multivesicular body protein 2b; chromatin modifying protein 2B", "tax_id": 10090, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (Disease Ontology:DOID:0111227); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:68942); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16041373;17242355;19144319;21183079;21750661;22366797;23284619;26495903;34855215;35454086", "class_list": "", "function": "A novel synaptopathy-defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia., [RefSeq, PubMed]; Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2B(intron5) Mutant in a Mouse Model of ALS-FTD Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 in the embryonic mouse neural tube, [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity)., [UniProtKB]; These data describe the first mouse model of dementia caused by CHMP2B mutation and provide new insights into the mechanisms of CHMP2B-induced neurodegeneration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UZ4;Q9CT65", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BJF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1J4-1", "uniprot_id": [ { "id": "DDB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1J4", "type": "external" } ], "mass": 126853.0, "length": 1140, "protein_name": "DNA damage-binding protein 1", "gene_name": "Ddb1", "organism": "Mouse", "refseq_name": "DNA damage-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_056550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056550", "type": "external" } ], "gene_names_uniprotkb": "Ddb1", "gene_names_refseq": "127kDa; Ddb1; p127-Ddb1", "protein_names_uniprotkb": "DNA damage-binding protein 1; DDB p127 subunit; Damage-specific DNA-binding protein 1; UV-damaged DNA-binding factor", "protein_names_refseq": "DDB p127 subunit; DNA damage-binding protein 1 isoform 2; DNA damage-binding protein 1; UV-damaged DNA-binding factor; damage-specific DNA-binding protein, DNA repair; damaged-DNA recognition protein 1", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); communication disorder (Disease Ontology:DOID:2033)", "pathway": " (mmu:13194); (R-MMU-110314); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-8951664)", "pathway_count": 9, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;10574459;12107171;17129780;17242355;21750661;22872234;24357321;25982117;26431207;26495903;26740625;27123980;28315936;28790135;31219806;31492966;33649389;34161765;34203471;34428180;34526995;35178836;35820727;36210013;37507081;37828378;38934719;39927985", "class_list": "", "function": "Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock., [UniProtKB, UniProtKB]; DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity., [RefSeq, PubMed]; Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but aggravates liver inflammation and fibrosis in MASH. Publication Status: Online-Only, [RefSeq, PubMed]; Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171, PubMed:26431207, PubMed:28790135). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:12107171). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (By similarity). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (By similarity). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (By similarity). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (PubMed:28790135). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (PubMed:24357321). Maternal factor required for proper zygotic genome activation and genome reprogramming (PubMed:24357321)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4D0;Q3U8G3;Q3UJC4;Q99LV3;Q9QYK0;Q9WV39", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding;GO:0071987 WD40-repeat domain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q3U1J4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925T6-1", "uniprot_id": [ { "id": "GRIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925T6", "type": "external" } ], "mass": 122058.0, "length": 1127, "protein_name": "Glutamate receptor-interacting protein 1", "gene_name": "Grip1", "organism": "Mouse", "refseq_name": "glutamate receptor-interacting protein 1 isoform 4", "refseq_ac": [ { "id": "NP_001264221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264221", "type": "external" } ], "gene_names_uniprotkb": "Grip1", "gene_names_refseq": "4931400F03Rik; GRIP; Grip1; eb", "protein_names_uniprotkb": "Glutamate receptor-interacting protein 1; GRIP-1", "protein_names_refseq": "eye blebs; glutamate receptor-interacting protein 1 isoform 4", "tax_id": 10090, "disease": "recessive dystrophic epidermolysis bullosa (Disease Ontology:DOID:0060642); Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 3 (Disease Ontology:DOID:0111406); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:74053); (R-MMU-416993)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11335060;11983858;11986669;12458226;15507123;15988012;16272139;21496646;21750661;34678516;35863680;9883737", "class_list": "", "function": "GRIP1 scaffolding protein is required for the formation and integrity of the dermo-epidermal junction and reveal the importance of PDZ domains in the organization of supramolecular structures essential for mammalian embryonic development., [RefSeq, PubMed]; Glutamate Receptor Interacting Protein 1 in the Dorsal CA1 Drives Alpha-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid Receptor Endocytosis and Exocytosis Bidirectionally and Mediates Forgetting, Exploratory, and Anxiety-like Behavior., [RefSeq, PubMed]; Investigated whether there is a link between growth inhibitory effect and transcriptional activation of PPARgamma in several gastrointestinal tumour cell lines [GRIP1tau], [RefSeq, PubMed]; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLQ3;Q8C0T3;Q925T5;Q925T7", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0030165 PDZ domain binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0007399 nervous system development;GO:0140059 dendrite arborization;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q925T6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUJ0-1", "uniprot_id": [ { "id": "HCST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUJ0", "type": "external" } ], "mass": 8114.0, "length": 79, "protein_name": "Hematopoietic cell signal transducer", "gene_name": "Hcst", "organism": "Mouse", "refseq_name": "hematopoietic cell signal transducer precursor", "refseq_ac": [ { "id": "NP_035957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035957", "type": "external" } ], "gene_names_uniprotkb": "Hcst; Dap10; Kap10", "gene_names_refseq": "DAP10; Hcst; KAP10", "protein_names_uniprotkb": "Hematopoietic cell signal transducer; DNAX-activation protein 10; Membrane protein DAP10; Transmembrane adapter protein KAP10", "protein_names_refseq": "DNAX-activation protein 10; hematopoietic cell signal transducer precursor; membrane protein DAP10; transmembrane adapter protein KAP10", "tax_id": 10090, "disease": "", "pathway": " (mmu:23900); (R-MMU-198933)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10426994;10528161;11491539;12426564;12426565;15294961;15365099;16086018;16887996;17100879;17785813;19251634;25605945;33829411", "class_list": "", "function": "CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway. Erratum:[Neurotherapeutics. 2021 Jul;18(3):2131. doi: 10.1007/s13311-021-01062-1. PMID: 33929711], [RefSeq, PubMed]; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1E7", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050776 regulation of immune response;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QUJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGT0-1", "uniprot_id": [ { "id": "OSTM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGT0", "type": "external" } ], "mass": 38000.0, "length": 338, "protein_name": "Osteopetrosis-associated transmembrane protein 1", "gene_name": "Ostm1", "organism": "Mouse", "refseq_name": "osteopetrosis-associated transmembrane protein 1 precursor", "refseq_ac": [ { "id": "NP_766004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766004", "type": "external" } ], "gene_names_uniprotkb": "Ostm1; Gl", "gene_names_refseq": "1200002H13Rik; HSPC019; Ostm1; gl", "protein_names_uniprotkb": "Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; Grey-lethal protein", "protein_names_refseq": "chloride channel 7 beta subunit; grey lethal osteopetrosis; osteopetrosis-associated transmembrane protein 1 precursor", "tax_id": 10090, "disease": "autosomal recessive osteopetrosis 5 (Disease Ontology:DOID:0110939)", "pathway": " (mmu:14628); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12627228;16525474;17242355;19144319;21183079;21750661;25428506;30899004;32764302;35216187", "class_list": "", "function": "Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet. Publication Status: Online-Only, [RefSeq, PubMed]; Ostm1 from Mouse to Human: Insights into Osteoclast Maturation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Required for osteoclast and melanocyte maturation and function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0030321 transepithelial chloride transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8BGT0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62191-1", "uniprot_id": [ { "id": "RO52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62191", "type": "external" } ], "mass": 54175.0, "length": 470, "protein_name": "E3 ubiquitin-protein ligase TRIM21", "gene_name": "Trim21", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trim21; Ro52; Ssa1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM21; 2.3.2.27; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Ro(SS-A); SS-A; Sjoegren syndrome type A antigen; Tripartite motif-containing protein 21", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-3134975); (R-MMU-9755511); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17579016;25605945;34428180;40885482;8625517", "class_list": "", "function": "E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2 (By similarity). Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination (By similarity). Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes (By similarity). A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome (By similarity). Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling (By similarity). Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3 (By similarity). Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway (By similarity). Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages (PubMed:17579016). Plays a role in the regulation of the cell cycle progression (By similarity). Enhances the decapping activity of DCP2 (By similarity). Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules (By similarity). At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified (By similarity). The common feature of these proteins is their ability to bind HY RNAs.2 (By similarity). Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (By similarity). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity). Also regulates autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability (By similarity). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (By similarity). During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation (By similarity). When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity (By similarity). Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0000932 P-body", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0000045 autophagosome assembly;GO:0032092 positive regulation of protein binding;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62191-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE49-1", "uniprot_id": [ { "id": "DOXA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE49", "type": "external" } ], "mass": 37588.0, "length": 341, "protein_name": "Dual oxidase maturation factor 1", "gene_name": "Duoxa1", "organism": "Mouse", "refseq_name": "dual oxidase maturation factor 1", "refseq_ac": [ { "id": "NP_001292191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292191", "type": "external" } ], "gene_names_uniprotkb": "Duoxa1", "gene_names_refseq": "Duoxa1; Nip1; Nip", "protein_names_uniprotkb": "Dual oxidase maturation factor 1; Dual oxidase activator 1", "protein_names_refseq": "Numb-interacting protein 1; dual oxidase activator 1; dual oxidase maturation factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213696); (R-MMU-209968)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20233719;21362455;21750661;32929281", "class_list": "", "function": "DUOXA1 is a novel p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation., [RefSeq, PubMed]; Nip1 has an important role in the guidance of neuronal differentiation through ROS generation and modulation of intermediate filaments, [RefSeq, PubMed]; Required for the maturation and transport of functional DUOX1 from the endoplasmic reticulum to the plasma membrane. Recruits DUOX1 to the apical cell membrane., [UniProtKB, UniProtKB]; Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ97", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:0010729 positive regulation of hydrogen peroxide biosynthetic process;GO:0015031 protein transport;GO:0045666 positive regulation of neuron differentiation;GO:0072659 protein localization to plasma membrane;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VE49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3J5-1", "uniprot_id": [ { "id": "DOCK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3J5", "type": "external" } ], "mass": 211704.0, "length": 1828, "protein_name": "Dedicator of cytokinesis protein 2", "gene_name": "Dock2", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 2", "refseq_ac": [ { "id": "NP_203538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203538", "type": "external" } ], "gene_names_uniprotkb": "Dock2", "gene_names_refseq": "CED-5; Dock2; Hch; MBC", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 2; Protein Hch", "protein_names_refseq": "dedicator of cytokinesis protein 2", "tax_id": 10090, "disease": "immunodeficiency 40 (Disease Ontology:DOID:0111951)", "pathway": " (mmu:94176); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-983231)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "11518968;12191913;12518436;12871644;19144319;19224205;20173027;21183079;21750661;25428506;25605945;29187734;31219806;32651375;34418053;34428180;35820727;36210013;39627609", "class_list": "", "function": "A review article on the role of DOCK2 in lymphocyte migration. Review article, [RefSeq, PubMed]; DOCK2 regulates T cell responsiveness through remodeling of actin cytoskeleton via Rac activation., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that activates monomeric GTPases by catalysing the release of bound GDP in exchange for free GTP (By similarity). Activates RAC1 and RAC2, but not CDC42 (By similarity). Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines (PubMed:11518968). May also participate in IL2 transcriptional activation via the activation of RAC2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Haematopoietic cell-specific CDM protein family member is indispensable for lymphocyte chemotaxis, [RefSeq, PubMed]; Plays a role in lymphocyte migration via Rac activation in the cytoskeleton Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRI4;Q99M79", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0042608 T cell receptor binding;GO:0160124 guanyl nucleotide exchange factor activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0046633 alpha-beta T cell proliferation;GO:0046631 alpha-beta T cell activation;GO:0006935 chemotaxis;GO:0016477 cell migration;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8C3J5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60847-1", "uniprot_id": [ { "id": "COCA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60847", "type": "external" } ], "mass": 340214.0, "length": 3120, "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "Col12a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XII) chain precursor", "refseq_ac": [ { "id": "NP_001277237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277237", "type": "external" } ], "gene_names_uniprotkb": "Col12a1", "gene_names_refseq": "Col12a1", "protein_names_uniprotkb": "Collagen alpha-1(XII) chain", "protein_names_refseq": "collagen alpha-1(XII) chain precursor; collagen alpha-1(XII) chain; procollagen, type XII, alpha 1", "tax_id": 10090, "disease": "Ullrich congenital muscular dystrophy 2 (Disease Ontology:DOID:0060948); Bethlem myopathy 2 (Disease Ontology:DOID:0061201)", "pathway": " (mmu:12816); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10419532;21670218;21750661;25428506;26495903;31219806;31599954;32152506;34428180;39927985;8601036", "class_list": "", "function": "Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 2, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "P70322", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005595 collagen type XII trimer;GO:0005614 interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0035987 endodermal cell differentiation;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q60847-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D676-1", "uniprot_id": [ { "id": "CLC2G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D676", "type": "external" } ], "mass": 30884.0, "length": 269, "protein_name": "C-type lectin domain family 2 member G", "gene_name": "Clec2g", "organism": "Mouse", "refseq_name": "C-type lectin domain family 2 member G isoform 2", "refseq_ac": [ { "id": "NP_001161695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161695", "type": "external" } ], "gene_names_uniprotkb": "Clec2g; Clec2f; Ddv10; Ocilrp1", "gene_names_refseq": "4632413B12Rik; Clec2g; Clr-c; Clr-d; Clrc; Clrd; Clrx; Ddv10; Ocilrp1", "protein_names_uniprotkb": "C-type lectin domain family 2 member G; DDV10; Ocil-related protein 1; Osteoclast inhibitory lectin-related protein 1", "protein_names_refseq": "C-type lectin domain family 2 member G isoform 2; C-type lectin-related protein C; ocil-related protein 1; osteoclast inhibitory lectin related protein; osteoclast inhibitory lectin-related protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70809)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12374791;12746323;16460835;16751398;21750661;25694214;26173808;32473917", "class_list": "glycogene", "function": "Both circulating B lymphocytes and CD11b-high Gr-1-high myeloid cells lose CLEC-2 following entry into secondary lymphoid organs., [RefSeq, PubMed]; CLEC-2 is an adhesive receptor that supports platelet arrest to podoplanin under venous shear. Src/Syk-dependent signalling stabilises platelet adhesion to podoplanin., [RefSeq, PubMed]; Data suggest that DDV10 is the long form of Clec2 g (Clec2g-L), and DDV10/Clec2g-L may play a role in the stratification and/or cornification of epithelial cells during differentiation., [RefSeq, PubMed]; Inhibits osteoclast formation., [UniProtKB, PubMed]; Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 117, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1AFZ6;Q3UUY2;Q80Z35;Q8BHH6", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0045671 negative regulation of osteoclast differentiation;GO:0051132 NK T cell activation;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D676-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54099-1", "uniprot_id": [ { "id": "DPOG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P54099", "type": "external" } ], "mass": 136758.0, "length": 1218, "protein_name": "DNA polymerase subunit gamma-1", "gene_name": "Polg", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Polg; Polg1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase subunit gamma-1; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; 4.2.99.-; 5'-deoxyribose-phosphate lyase; Mitochondrial DNA polymerase catalytic subunit; PolG-alpha; PolgA", "protein_names_refseq": "", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cerebellar ataxia (Disease Ontology:DOID:0050753); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); mitochondrial DNA depletion syndrome 4b (Disease Ontology:DOID:0080123); sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (Disease Ontology:DOID:0111276); autosomal dominant progressive external ophthalmoplegia 1 (Disease Ontology:DOID:0111521); autosomal recessive progressive external ophthalmoplegia 1 (Disease Ontology:DOID:0111522); premature menopause (Disease Ontology:DOID:10787); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); mood disorder (Disease Ontology:DOID:3324); progeria (Disease Ontology:DOID:3911); primary ovarian insufficiency (Disease Ontology:DOID:5426); peripheral nervous system disease (Disease Ontology:DOID:574); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (R-MMU-9913635)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11058962;15164064;21750661;26095671;31219806", "class_list": "", "function": "Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates (By similarity) (PubMed:26095671). Has 5' -> 3' polymerase activity. Functionally interacts with TWNK and SSBP1 at the replication fork to form a highly processive replisome, where TWNK unwinds the double-stranded DNA template prior to replication and SSBP1 covers the parental heavy strand to enable continuous replication of the entire mitochondrial genome. A single nucleotide incorporation cycle includes binding of the incoming nucleotide at the insertion site, a phosphodiester bond formation reaction that extends the 3'-end of the primer DNA, and translocation of the primer terminus to the post-insertion site. After completing replication of a mtDNA strand, mediates 3' -> 5' exonucleolytic degradation at the nick to enable proper ligation (By similarity) (PubMed:26095671). Highly accurate due to high nucleotide selectivity and 3' -> 5' exonucleolytic proofreading. Proficiently corrects base substitutions, single-base additions and deletions in non-repetitive sequences and short repeats, but displays lower proofreading activity when replicating longer homopolymeric stretches. Exerts exonuclease activity toward single-stranded DNA and double-stranded DNA containing 3'-terminal mispairs. When a misincorporation occurs, transitions from replication to a pro-nucleolytic editing mode and removes the missincorporated nucleoside in the exonuclease active site. Proceeds via an SN2 nucleolytic mechanism in which Asp-198 catalyzes phosphodiester bond hydrolysis and Glu-200 stabilizes the leaving group. As a result the primer strand becomes one nucleotide shorter and is positioned in the post-insertion site, ready to resume DNA synthesis (By similarity) (PubMed:15164064, PubMed:26095671). Exerts 5'-deoxyribose phosphate (dRP) lyase activity and mediates repair-associated mtDNA synthesis (gap filling) in base-excision repair pathway. Catalyzes the release of the 5'-terminal 2-deoxyribose-5-phosphate sugar moiety from incised apurinic/apyrimidinic (AP) sites to produce a substrate for DNA ligase. The dRP lyase reaction does not require divalent metal ions and likely proceeds via a Schiff base intermediate in a beta-elimination reaction mechanism (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI28", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0002020 protease binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0043195 terminal bouton", "go_biological_process": "GO:0045004 DNA replication proofreading;GO:0006284 base-excision repair;GO:0008340 determination of adult lifespan;GO:0006264 mitochondrial DNA replication;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54099-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3Y5-1", "uniprot_id": [ { "id": "CS047_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3Y5", "type": "external" } ], "mass": 44410.0, "length": 413, "protein_name": "Uncharacterized protein C19orf47 homolog", "gene_name": "2310022A10Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C19orf47 homolog isoform 2", "refseq_ac": [ { "id": "NP_001116239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116239", "type": "external" } ], "gene_names_uniprotkb": "2310022A10Rik", "gene_names_refseq": "2310022A10Rik", "protein_names_uniprotkb": "Uncharacterized protein C19orf47 homolog", "protein_names_refseq": "uncharacterized protein C19orf47 homolog isoform 2; uncharacterized protein C19orf47 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66367)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22517741;36852467;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3US50;Q8BVL8;Q8C1M9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R3Y5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXD4-1", "uniprot_id": [ { "id": "DNMBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6TXD4", "type": "external" } ], "mass": 177277.0, "length": 1580, "protein_name": "Dynamin-binding protein", "gene_name": "Dnmbp", "organism": "Mouse", "refseq_name": "dynamin-binding protein isoform 2", "refseq_ac": [ { "id": "NP_001293017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293017", "type": "external" } ], "gene_names_uniprotkb": "Dnmbp; Kiaa1010; Tuba", "gene_names_refseq": "2410003L07Rik; 2410003M15Rik; Dnmbp; TUBA", "protein_names_uniprotkb": "Dynamin-binding protein; Scaffold protein Tuba", "protein_names_refseq": "dynamin-binding protein isoform 2; scaffold protein Tuba", "tax_id": 10090, "disease": "cataract 48 (Disease Ontology:DOID:0070354)", "pathway": " (mmu:71972); (R-MMU-9013148)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14506234;16757518;21750661;31219806;34428180;40885482", "class_list": "", "function": "Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (PubMed:14506234)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Tuba-stimulated dorsal ruffling might represent a novel mechanism for the coordination of N-WASP-dependent cytoskeletal rearrangements, and Tuba function is implicated in motility processes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ05;Q8CEW8;Q8R0Y2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0060271 cilium assembly;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6TXD4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFC7-1", "uniprot_id": [ { "id": "CLASR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFC7", "type": "external" } ], "mass": 76825.0, "length": 668, "protein_name": "CLK4-associating serine/arginine rich protein", "gene_name": "Clasrp", "organism": "Mouse", "refseq_name": "CLK4-associating serine/arginine rich protein", "refseq_ac": [ { "id": "NP_057889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057889", "type": "external" } ], "gene_names_uniprotkb": "Clasrp; Clasp; Sfrs16; Srsf16; Swap2", "gene_names_refseq": "Clasp; Clasrp; Sfrs16; Srsf16; Swap2", "protein_names_uniprotkb": "CLK4-associating serine/arginine rich protein; Clk4-associating SR-related protein; Serine/arginine-rich splicing factor 16; Splicing factor, arginine/serine-rich 16; Suppressor of white-apricot homolog 2", "protein_names_refseq": "CLK4-associating serine/arginine rich protein; Clk4 associating SR-related protein; serine/arginine-rich splicing factor 16; splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila); suppressor of white-apricot homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53609)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12169693;19131326;20657840;21183079;21750661;34418053", "class_list": "", "function": "Clasp is a binding partner of Clk4 and may be involved in the regulation of the activity of Clk kinase family, [RefSeq, PubMed]; Loss of Upf2 during fetal liver development causes a change in expression of many genes, including Clasrp/Sfrs16 (Table S1). Publication Status: Online-Only, [RefSeq, PubMed]; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family., [UniProtKB]; The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKW4;Q8CFC8;Q9Z2N3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CFC7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGS7-1", "uniprot_id": [ { "id": "CEPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGS7", "type": "external" } ], "mass": 46434.0, "length": 416, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "Cept1", "organism": "Mouse", "refseq_name": "choline/ethanolaminephosphotransferase 1 isoform 2", "refseq_ac": [ { "id": "NP_001280623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280623", "type": "external" } ], "gene_names_uniprotkb": "Cept1", "gene_names_refseq": "9930118K05Rik; Cept1; mCEPT1", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2; mCEPT1", "protein_names_refseq": "1-alkenyl-2-acylglycerol choline phosphotransferase; choline/ethanolaminephosphotransferase 1 isoform 2", "tax_id": 10090, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:99712); (R-MMU-1483191); (R-MMU-1483213)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;25428506;30779550;31599954;34428180", "class_list": "", "function": "Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC64", "ec_number_list": [ { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGS7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVF9-1", "uniprot_id": [ { "id": "CLC2I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVF9", "type": "external" } ], "mass": 24671.0, "length": 217, "protein_name": "C-type lectin domain family 2 member I", "gene_name": "Clec2i", "organism": "Mouse", "refseq_name": "C-type lectin domain family 2 member I isoform 1", "refseq_ac": [ { "id": "NP_001276635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276635", "type": "external" } ], "gene_names_uniprotkb": "Clec2i; Clrg; Dcl1; Ocilrp2", "gene_names_refseq": "Clec2i; Clr-g; Clrg; Dcl1; LCL-1; OCILrP2", "protein_names_uniprotkb": "C-type lectin domain family 2 member I; C-type lectin-related protein DCL1; C-type lectin-related protein G; Clr-g; LCL-1; Lymphoid-derived C-type lectin-1; Ocil-related protein 2; Osteoclast inhibitory lectin-related protein 2", "protein_names_refseq": "C-type lectin domain family 2 member I isoform 1; C-type lectin-related protein DCL1; C-type lectin-related protein G; lymphoid-derived C-type lectin-1; ocil-related protein 2; osteoclast inhibitory lectin related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93675)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11398965;12374791;12858173;15963483;16143319;16751398;21750661;24631687;25411776;26740625;36300111", "class_list": "glycogene", "function": "Data show OCILRP2 binding to DAP12 resulting in Raf-MAP kinase pathways activation and T-cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a novel family of genes, named Clr, encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6., [RefSeq, PubMed]; Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production., [UniProtKB, PubMed, PubMed]; May facilitate lipid rafts and immunological synapse formation during T cell interaction with antigen presenting cells., [RefSeq, PubMed]; Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr are intertwined in a genetically conserved NKC region., [RefSeq, PubMed]; Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage. Publication Status: Online-Only, [RefSeq, PubMed]; OCILRP2 is a regulator of dendritic cells maturation and differentiation following TLR4 activation., [RefSeq, PubMed]; Studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 110, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1AFZ2;Q7TSP6;Q7TSP7;Q8BFR3;Q924B1", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001765 membrane raft assembly;GO:0043113 receptor clustering;GO:0045671 negative regulation of osteoclast differentiation;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WVF9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55229-1", "uniprot_id": [ { "id": "CHKB_MOUSE", "url": "https://www.uniprot.org/uniprot/O55229", "type": "external" } ], "mass": 45126.0, "length": 394, "protein_name": "Choline/ethanolamine kinase", "gene_name": "Chkb", "organism": "Mouse", "refseq_name": "choline/ethanolamine kinase", "refseq_ac": [ { "id": "NP_031718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031718", "type": "external" } ], "gene_names_uniprotkb": "Chkb; Chetk; Chkl", "gene_names_refseq": "Chetk; Chkb; Chkl; Ck/Ek-beta; Ck/Ek; Ckb; Ckekb; Ck; Ek", "protein_names_uniprotkb": "Choline/ethanolamine kinase; 2.7.1.32; 2.7.1.82; CKB; CKEKB; CK; Choline kinase beta; EK; Ethanolamine kinase; choline/ethanolamine kinase beta", "protein_names_refseq": "choline/ethanolamine kinase-b; choline/ethanolamine kinase; choline/ethanolaminekinase", "tax_id": 10090, "disease": "megaconial type congenital muscular dystrophy (Disease Ontology:DOID:0110632); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826); recurrent hypersomnia (Disease Ontology:DOID:8619); narcolepsy (Disease Ontology:DOID:8986); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:12651); (R-MMU-1483191); (R-MMU-1483213)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11964179;16371353;16490392;19236939;21750661;24637075;25428506;25451916;30084848;31219806;34428180;9714798", "class_list": "", "function": "CHKB is a new modulator of bone homeostasis, [RefSeq, PubMed]; Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex., [RefSeq, PubMed]; Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis., [UniProtKB, UniProtKB]; Our data indicate that choline kinase beta plays an important role in endochondral bone formation by modulating growth plate physiology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004103 choline kinase activity;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0006656 phosphatidylcholine biosynthetic process;GO:0007517 muscle organ development;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O55229-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923P0-1", "uniprot_id": [ { "id": "COKA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923P0", "type": "external" } ], "mass": 140926.0, "length": 1320, "protein_name": "Collagen alpha-1(XX) chain", "gene_name": "Col20a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XX) chain precursor", "refseq_ac": [ { "id": "NP_082794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082794", "type": "external" } ], "gene_names_uniprotkb": "Col20a1", "gene_names_refseq": "1700051I12Rik; Col20a1", "protein_names_uniprotkb": "Collagen alpha-1(XX) chain", "protein_names_refseq": "collagen alpha-1(XX) chain precursor; collagen alpha-1(XX) chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:73368); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Probable collagen protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A8WIS2;Q91WC4;Q923P1;Q923P2;Q9D9L7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:1990319 collagen type XX trimer;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923P0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64462-1", "uniprot_id": [ { "id": "CP4B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64462", "type": "external" } ], "mass": 58900.0, "length": 511, "protein_name": "Cytochrome P450 4B1", "gene_name": "Cyp4b1", "organism": "Mouse", "refseq_name": "cytochrome P450 4B1", "refseq_ac": [ { "id": "NP_031849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031849", "type": "external" } ], "gene_names_uniprotkb": "Cyp4b1", "gene_names_refseq": "CYPIVB1; Cyp4b1", "protein_names_uniprotkb": "Cytochrome P450 4B1; 1.14.14.1; CYPIVB1; Cytochrome P450 CYP4B1", "protein_names_refseq": "cytochrome P450 4B1; cytochrome P450, subfamily IV B, polypeptide 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13120); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12849993;19307459;21750661;34428180;35820727;37507081;7639529", "class_list": "", "function": "Catalyzes the omega- and (omega-1)-hydroxylation of saturated fatty acids and n-alkanes (PubMed:7639529). Also bioactivates xenobiotics such as the procarcinogen 3-methoxy-4-aminoazobenzene and the cyclic arylamines 2-aminofluorene and 2-aminoanthracene (PubMed:7639529). In addition, catalyzes O-dealkylation of 7-ethoxycoumarin (By similarity). Functions at the interface of xenobiotic and endobiotic metabolism, contributing both to fatty acid and hydrocarbon oxidation and to the bioactivation of diverse xenobiotics (PubMed:7639529). Preferentially hydroxylates the terminal carbon (omega-hydroxylation) of medium-chain fatty acids (C8-C10), with regioselectivity decreasing as chain length increases. C8 fatty acids and C7 n-alkanes display optimal chain length for regioselective omega-hydroxylation, and n-alkanes (C7-C10) are generally turned over faster and with higher regioselectivity than the corresponding fatty acids. In addition to omega/omega-1 hydroxylation, also catalyzes alpha-, beta-, gamma- and delta-hydroxylation of mid-chain length fatty acids, whereas fatty alcohols of the same chain length are almost exclusively hydroxylated at the omega, omega-1 and omega-2 positions (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Data show that the 5' flanking region of the Cyp4b1 gene exhibits promoter activity when expressed in different cell lines and that a 98-truncated fragment represents the minimal sequence required for basal transcription., [RefSeq, PubMed]; Increased CYP4B1 mRNA is associated with the inhibition of dextran sulfate sodium-induced colitis by caffeic acid in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:1901363 heterocyclic compound binding;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0018879 biphenyl metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64462-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RX88-1", "uniprot_id": [ { "id": "CSPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RX88", "type": "external" } ], "mass": 138312.0, "length": 1205, "protein_name": "Centrosome and spindle pole associated protein 1", "gene_name": "Cspp1", "organism": "Mouse", "refseq_name": "centrosome and spindle pole associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_080769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080769", "type": "external" } ], "gene_names_uniprotkb": "Cspp1; Cspp", "gene_names_refseq": "2310020J12Rik; 4930413O22Rik; Cspp1; Cspp2; Cspp3", "protein_names_uniprotkb": "Centrosome and spindle pole associated protein 1", "protein_names_refseq": "centrosome and spindle pole associated protein 1 isoform 1; centrosome/spindle pole-associated protein 2; centrosome/spindle pole-associated protein 3", "tax_id": 10090, "disease": "Joubert syndrome 21 (Disease Ontology:DOID:0110990)", "pathway": " (mmu:211660)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19129481;20485683;21183079;21750661;31219806;34678516", "class_list": "", "function": "May play a role in cell-cycle-dependent microtubule organization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C7SBE3;C7SBE4;Q8CCQ4;Q8VE83;Q9CQD5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051781 positive regulation of cell division;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B2RX88-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLA1-1", "uniprot_id": [ { "id": "DLEC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLA1", "type": "external" } ], "mass": 71183.0, "length": 635, "protein_name": "Deleted in lung and esophageal cancer protein 1 homolog", "gene_name": "Dlec1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dlec1", "gene_names_refseq": "", "protein_names_uniprotkb": "Deleted in lung and esophageal cancer protein 1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;33144677;40473901", "class_list": "", "function": "Essential for spermatogenesis and male fertility (PubMed:33144677). May play an important role in sperm head and tail formation (PubMed:33144677). May act as a tumor suppressor by inhibiting cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0002357 defense response to tumor cell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BLA1-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEE0-1", "uniprot_id": [ { "id": "CEP57_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEE0", "type": "external" } ], "mass": 56909.0, "length": 500, "protein_name": "Centrosomal protein of 57 kDa", "gene_name": "Cep57", "organism": "Mouse", "refseq_name": "centrosomal protein of 57 kDa isoform 2", "refseq_ac": [ { "id": "NP_001297650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297650", "type": "external" } ], "gene_names_uniprotkb": "Cep57; Kiaa0092; Tsp57", "gene_names_refseq": "3110002L15Rik; 4921510P06Rik; 4931428M20Rik; Cep57; Tsp57; mKIAA0092", "protein_names_uniprotkb": "Centrosomal protein of 57 kDa; Cep57; Testis-specific protein 57; Translokin", "protein_names_refseq": "centrosomal protein of 57 kDa isoform 2; centrosomal protein of 57 kDa; testis-specific protein 57; translokin", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome 2 (Disease Ontology:DOID:0080142)", "pathway": " (mmu:74360); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "12717444;12954732;18294141;19804566;21306487;21750661;23569207;30035751;31219806;34428180", "class_list": "", "function": "Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody, [RefSeq, PubMed]; Data suggest that Cep57 serves as a link with its N-terminus anchored to the centriole or centromatrix and its C-terminus to microtubules., [RefSeq, PubMed]; Data suggest that translokin acts as a key negative regulator in the pathway that drives nuclear import of cyclin D1, thus contributing to prevent pRB inactivation and to maintain cellular quiescence., [RefSeq, PubMed]; Report the identification of four Translokin partners: sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, [RefSeq, PubMed]; This study identifies Cep57 as a haploinsufficient tumor suppressor with biologically diverse roles in centrosome maturation and Fgf2-mediated bone formation., [RefSeq, PubMed]; Tsp57 protein plays a role in the postmeiotic phase of germ cell differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJE6;Q6ZQJ3;Q7TN18;Q80X65;Q810F2;Q9D4J4;Q9D5S4;Q9D5W5", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0017134 fibroblast growth factor binding;GO:0043015 gamma-tubulin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0007286 spermatid development;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CEE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQX7-1", "uniprot_id": [ { "id": "CHSS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IQX7", "type": "external" } ], "mass": 85534.0, "length": 774, "protein_name": "Chondroitin-polymerizing factor, non-catalytic subunit", "gene_name": "Chpf", "organism": "Mouse", "refseq_name": "chondroitin sulfate synthase 2 isoform b", "refseq_ac": [ { "id": "NP_001001565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001565", "type": "external" } ], "gene_names_uniprotkb": "Chpf; Css2; D1Bwg1363e", "gene_names_refseq": "1700028N03Rik; Chpf; D1Bwg1363e", "protein_names_uniprotkb": "Chondroitin-polymerizing factor, non-catalytic subunit; ChPF; Chondroitin sulfate synthase 2", "protein_names_refseq": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II; N-acetylgalactosaminyltransferase 2; chondroitin glucuronyltransferase 2; chondroitin sulfate synthase 2 isoform b; chondroitin sulfate synthase 2; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II", "tax_id": 10090, "disease": "", "pathway": " (mmu:74241); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20729547;21750661;22082830;25428506;26495903;28011936;34428180;35820727;37828378;38190270", "class_list": "glycogene;glycosyltransferase", "function": "Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function, [RefSeq, PubMed]; May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress., [UniProtKB, UniProtKB]; MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer., [RefSeq, PubMed]; Non-catalytic component of CHSY1-CHPF2 and CHSY3-CHPF2 chondroitin sulfate synthase complexes. CHPF associates with catalytically active chondroitin synthases (CHSY1/3) within heterodimeric complexes and likely plays a structural or stabilizing role in chondroitin sulfate chain polymerization. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PUB9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6IQX7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88876-1", "uniprot_id": [ { "id": "DHRS3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88876", "type": "external" } ], "mass": 33652.0, "length": 302, "protein_name": "Short-chain dehydrogenase/reductase 3", "gene_name": "Dhrs3", "organism": "Mouse", "refseq_name": "short-chain dehydrogenase/reductase 3 isoform 1", "refseq_ac": [ { "id": "NP_035433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035433", "type": "external" } ], "gene_names_uniprotkb": "Dhrs3; Rsdr1", "gene_names_refseq": "Dhrs3; Rsdr1; retSDR1", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase 3; 1.1.1.300; Retinal short-chain dehydrogenase/reductase 1; retSDR1", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 3; retinal short-chain dehydrogenase/reductase 1; short-chain dehydrogenase/reductase 3 isoform 1; short-chain dehydrogenase/reductase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20148); (R-MMU-2187335); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;25428506;30084848;31219806;33485967;34428180;9705317;9853961", "class_list": "", "function": "Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAD1;Q91WR0;Q91XC3;Q922A6", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0060021 roof of mouth development;GO:0060349 bone morphogenesis;GO:0030278 regulation of ossification;GO:0048385 regulation of retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1U1-1", "uniprot_id": [ { "id": "COG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1U1", "type": "external" } ], "mass": 88661.0, "length": 785, "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "Cog4", "organism": "Mouse", "refseq_name": "conserved oligomeric Golgi complex subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_598734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598734", "type": "external" } ], "gene_names_uniprotkb": "Cog4", "gene_names_refseq": "Cog4; D8Ertd515e", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 4; COG complex subunit 4; Component of oligomeric Golgi complex 4", "protein_names_refseq": "COG complex subunit 4; conserved oligomeric Golgi complex subunit 4 isoform 1; conserved oligomeric Golgi complex subunit 4", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIj (Disease Ontology:DOID:0070262); Saul-Wilson syndrome (Disease Ontology:DOID:0111673)", "pathway": " (mmu:102339); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "21750661;22872234;25428506;30084848;31219806;34428180", "class_list": "", "function": "Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9K1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R1U1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0F4-1", "uniprot_id": [ { "id": "CIB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0F4", "type": "external" } ], "mass": 21763.0, "length": 191, "protein_name": "Calcium and integrin-binding protein 1", "gene_name": "Cib1", "organism": "Mouse", "refseq_name": "calcium and integrin-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001278204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278204", "type": "external" } ], "gene_names_uniprotkb": "Cib1; Cib; Kip; Prkdcip", "gene_names_refseq": "Cib1; Cibkip; Kip; Prkdcip", "protein_names_uniprotkb": "Calcium and integrin-binding protein 1; CIB; Calmyrin; DNA-PKcs-interacting protein; KIP; Kinase-interacting protein", "protein_names_refseq": "CIB; DNA-PKcs-interacting protein; calcium and integrin binding, protein kinase interacting protein; calcium and integrin-binding protein 1 isoform 2; calcium and integrin-binding protein 1; calmyrin; kinase-interacting protein; protein kinase, DNA activated, catalytic polypeptide interacting protein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); epidermodysplasia verruciformis (Disease Ontology:DOID:13777)", "pathway": " (mmu:23991)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10051332;10826701;16418530;16982698;17975111;17994197;18989529;19691476;20639889;20804551;21750661;22128142;29084757;29255404;32307772;32917726;34428180", "class_list": "", "function": "Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components., [RefSeq, PubMed]; Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid beta peptide using CRISPR/Cas9-based screening system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN80", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z0F4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D084-1", "uniprot_id": [ { "id": "CENPS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D084", "type": "external" } ], "mass": 16335.0, "length": 142, "protein_name": "Centromere protein S", "gene_name": "Cenps", "organism": "Mouse", "refseq_name": "centromere protein S", "refseq_ac": [ { "id": "NP_081539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081539", "type": "external" } ], "gene_names_uniprotkb": "Cenps; Apitd1; FAAP16; MHF1", "gene_names_refseq": "2610040C18Rik; 2810407L01Rik; Apitd1; CENP-S; Cenps", "protein_names_uniprotkb": "Centromere protein S; Apoptosis-inducing TAF9-like domain-containing protein 1 homolog; CENP-S; FANCM-interacting histone fold protein 1", "protein_names_refseq": "FANCM-interacting histone fold protein 1; apoptosis-inducing TAF9-like domain-containing protein 1 homolog; centromere protein S; ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69928); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-6783310); (R-MMU-68877); (R-MMU-9648025); (R-MMU-9833482)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH77;Q80ZS2;Q8BH28", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D084-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07141-1", "uniprot_id": [ { "id": "CSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P07141", "type": "external" } ], "mass": 60649.0, "length": 552, "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "Csf1", "organism": "Mouse", "refseq_name": "macrophage colony-stimulating factor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001107001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107001", "type": "external" } ], "gene_names_uniprotkb": "Csf1; Csfm", "gene_names_refseq": "BAP025; Csf1; Csfm; MCSF; Mhdabap25; PG-M-CSF; op", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1; CSF-1; MCSF; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor", "protein_names_refseq": "macrophage colony-stimulating factor 1 isoform 2 precursor; osteopetrosis; proteoglycan macrophage colony-stimulating factor", "tax_id": 10090, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); osteopetrosis (Disease Ontology:DOID:13533); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); high grade glioma (Disease Ontology:DOID:3070); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); end stage renal disease (Disease Ontology:DOID:783); amyloidosis (Disease Ontology:DOID:9120); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:12977); (R-MMU-381426); (R-MMU-449836); (R-MMU-8957275); (R-MMU-9856649)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12074592;12379742;1733926;1874443;19017797;21750661;2188141;2457916;31599954;3493488;3494232;3925458;8357831", "class_list": "", "function": "Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 3, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U395;Q8R3C8", "ec_number_list": [], "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0030316 osteoclast differentiation;GO:0032946 positive regulation of mononuclear cell proliferation;GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0042488 positive regulation of odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P07141-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q33DR2-1", "uniprot_id": [ { "id": "DPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q33DR2", "type": "external" } ], "mass": 45895.0, "length": 409, "protein_name": "All trans-polyprenyl-diphosphate synthase PDSS1", "gene_name": "Pdss1", "organism": "Mouse", "refseq_name": "all trans-polyprenyl-diphosphate synthase PDSS1 isoform 1", "refseq_ac": [ { "id": "NP_062374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062374", "type": "external" } ], "gene_names_uniprotkb": "Pdss1; Dps1; Sps1; Tprt", "gene_names_refseq": "2610203G20Rik; 2700031G06Rik; Pdss1; TPT 1; TPT; Tprt; mDLP1; mSPS1", "protein_names_uniprotkb": "All trans-polyprenyl-diphosphate synthase PDSS1; 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl-diphosphate synthase subunit 1; Solanesyl-diphosphate synthase subunit 1; TPT 1; Trans-prenyltransferase 1", "protein_names_refseq": "all trans-polyprenyl-diphosphate synthase PDSS1 isoform 1; all trans-polyprenyl-diphosphate synthase PDSS1; all-trans-decaprenyl-diphosphate synthase subunit 1; decaprenyl pyrophosphate synthase subunit 1; decaprenyl pyrophosphate synthetase subunit 1; decaprenyl-diphosphate synthase subunit 1; solanesyl-diphosphate synthase subunit 1; subunit 1 of solanesyl diphosphate synthase; trans-prenyltransferase 1", "tax_id": 10090, "disease": "primary coenzyme Q10 deficiency 2 (Disease Ontology:DOID:0070239)", "pathway": " (mmu:56075); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10972372;16262699;21750661;25428506;37828378", "class_list": "", "function": "Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699)., [UniProtKB, PubMed]; Murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1) [DLP1], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJW9;Q9WU69", "ec_number_list": [ { "id": "2.5.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.91", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004659 prenyltransferase activity;GO:0097269 all-trans-decaprenyl-diphosphate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:0032478 heterotetrameric polyprenyl diphosphate synthase complex;GO:0032476 polyprenyl diphosphate synthase complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q33DR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UP3-1", "uniprot_id": [ { "id": "DGKZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UP3", "type": "external" } ], "mass": 104031.0, "length": 929, "protein_name": "Diacylglycerol kinase zeta", "gene_name": "Dgkz", "organism": "Mouse", "refseq_name": "diacylglycerol kinase zeta isoform 2", "refseq_ac": [ { "id": "NP_612179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612179", "type": "external" } ], "gene_names_uniprotkb": "Dgkz", "gene_names_refseq": "Dgkz; E130307B02Rik; F730209L11Rik; mDGK[z]", "protein_names_uniprotkb": "Diacylglycerol kinase zeta; 2.7.1.107; 2.7.1.93; DAG kinase zeta; DGK-zeta; Diglyceride kinase zeta", "protein_names_refseq": "DAG kinase zeta; DGK-zeta; diacylglycerol kinase zeta isoform 2; diglyceride kinase zeta", "tax_id": 10090, "disease": "", "pathway": " (mmu:104418); (R-MMU-114508)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12883552;16055737;20023381;21750661;27739494;30084848;31219806;37918056", "class_list": "", "function": "DGK-zeta, syntrophin, and Rac1 form a regulated signaling complex that controls polarized outgrowth in neuronal cells, [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12883552). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:12883552). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (PubMed:12883552). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (PubMed:27739494). Regulates RASGRP1 activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation., [RefSeq, PubMed]; Diacylglycerol kinase zeta functions as a physiological negative regulator of tcr signaling and t-cell activation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AHJ6", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0004857 enzyme inhibitor activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UP3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ90-1", "uniprot_id": [ { "id": "CI085_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ90", "type": "external" } ], "mass": 17730.0, "length": 155, "protein_name": "Uncharacterized protein C9orf85 homolog", "gene_name": "1110059E24Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C9orf85 homolog", "refseq_ac": [ { "id": "NP_079699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079699", "type": "external" } ], "gene_names_uniprotkb": "1110059E24Rik", "gene_names_refseq": "1110059E24Rik", "protein_names_uniprotkb": "Uncharacterized protein C9orf85 homolog", "protein_names_refseq": "uncharacterized protein C9orf85 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66206)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29974-1", "uniprot_id": [ { "id": "CNGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P29974", "type": "external" } ], "mass": 79460.0, "length": 684, "protein_name": "Cyclic nucleotide-gated channel alpha-1", "gene_name": "Cnga1", "organism": "Mouse", "refseq_name": "cyclic nucleotide-gated channel alpha-1", "refseq_ac": [ { "id": "NP_031749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031749", "type": "external" } ], "gene_names_uniprotkb": "Cnga1; Cncg1; Cncg", "gene_names_refseq": "Cncg; Cnga1", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated cation channel subunit alpha; cGMP-gated cation channel alpha-1", "protein_names_refseq": "CNG channel alpha-1; CNG-1; CNG1; cGMP-gated cation channel alpha-1; cyclic nucleotide gated channel, cGMP gated; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated cation channel subunit alpha; rod photoreceptor cGMP-gated channel subunit alpha", "tax_id": 10090, "disease": "retinitis pigmentosa 49 (Disease Ontology:DOID:0110377); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:12788); (R-MMU-2485179); (R-MMU-2514859)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11764791;1372902;21750661;34418172;34428180;7540868", "class_list": "", "function": "Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels., [UniProtKB, UniProtKB, UniProtKB]; Retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGA1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ09;Q60776", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005272 sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051899 membrane depolarization;GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29974-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49183-1", "uniprot_id": [ { "id": "DNAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P49183", "type": "external" } ], "mass": 32027.0, "length": 284, "protein_name": "Deoxyribonuclease-1", "gene_name": "Dnase1", "organism": "Mouse", "refseq_name": "deoxyribonuclease-1 precursor", "refseq_ac": [ { "id": "NP_034191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034191", "type": "external" } ], "gene_names_uniprotkb": "Dnase1; Dnl1", "gene_names_refseq": "DNaseI; Dnase1; Dnl1", "protein_names_uniprotkb": "Deoxyribonuclease-1; 3.1.21.1; DNase I; Deoxyribonuclease I", "protein_names_refseq": "deoxyribonuclease-1 precursor; deoxyribonuclease-1", "tax_id": 10090, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); primary biliary cholangitis (Disease Ontology:DOID:12236); autoimmune hepatitis (Disease Ontology:DOID:2048); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:13419)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10835632;15015938;21750661;29191910;38888971;7857306;9192086", "class_list": "", "function": "A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. Publication Status: Online-Only, [RefSeq, PubMed]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:29191910). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70532", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0004536 DNA nuclease activity;GO:0004530 deoxyribonuclease I activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006915 apoptotic process;GO:0006308 DNA catabolic process;GO:0002673 regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49183-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70397-1", "uniprot_id": [ { "id": "DLX6_MOUSE", "url": "https://www.uniprot.org/uniprot/P70397", "type": "external" } ], "mass": 19677.0, "length": 175, "protein_name": "Homeobox protein DLX-6", "gene_name": "Dlx6", "organism": "Mouse", "refseq_name": "homeobox protein DLX-6", "refseq_ac": [ { "id": "NP_034187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034187", "type": "external" } ], "gene_names_uniprotkb": "Dlx6", "gene_names_refseq": "Dlx6", "protein_names_uniprotkb": "Homeobox protein DLX-6", "protein_names_refseq": "homeobox protein DLX-6", "tax_id": 10090, "disease": "split hand-foot malformation 1 (Disease Ontology:DOID:0090021)", "pathway": " (mmu:13396)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18280462;21750661;31219806;35909540;8855272;9415433", "class_list": "", "function": "Distal-less homeobox genes Dlx5/6 regulate Mullerian duct regression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUM1;A5HKN2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0042472 inner ear morphogenesis;GO:0030326 embryonic limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70397-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54103-1", "uniprot_id": [ { "id": "DNJC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P54103", "type": "external" } ], "mass": 71722.0, "length": 621, "protein_name": "DnaJ homolog subfamily C member 2", "gene_name": "Dnajc2", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 2 isoform 1", "refseq_ac": [ { "id": "NP_033610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033610", "type": "external" } ], "gene_names_uniprotkb": "Dnajc2; Mida1; Zrf1", "gene_names_refseq": "Dnajc2; MIDA1; Zrf1; Zrf2", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 2; MIDA1; Mouse Id associate 1; Zuotin-related factor 1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 2; Id associate 1; dnaJ homolog subfamily C member 2 isoform 1; dnaJ homolog subfamily C member 2; zuotin related factor 2; zuotin-related factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22791); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10581180;10971652;17622165;21183079;21750661;27754813;28242756;28528544;31230751;34887587;7559602;8666407", "class_list": "", "function": "Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Invalidation of DNAJC2 leads to early post-implantation lethality of mouse embryos. Dnajc2 is expressed throughout early mouse embryogenesis. Maternal Dnajc2 mRNAs allow early preimplantation mouse embryonic development., [RefSeq, PubMed]; These findings reveal a mechanism by which nutrient sensing pathways impact on cell senescence through the activation of mTORC1-S6 kinases and the phosphorylation of ZRF1., [RefSeq, PubMed]; Zrf1 is identified as a novel regulator of the mesodermal lineage that might facilitate spatiotemporal expression of genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61866", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0043022 ribosome binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P54103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35492-1", "uniprot_id": [ { "id": "CLK3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35492", "type": "external" } ], "mass": 58499.0, "length": 490, "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "Clk3", "organism": "Mouse", "refseq_name": "dual specificity protein kinase CLK3 isoform 1", "refseq_ac": [ { "id": "NP_001397105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397105", "type": "external" } ], "gene_names_uniprotkb": "Clk3", "gene_names_refseq": "Clk3", "protein_names_uniprotkb": "Dual specificity protein kinase CLK3; 2.7.12.1; CDC-like kinase 3", "protein_names_refseq": "cdc2/CDC28-like protein kinase 3; dual specificity protein kinase CLK3 isoform 1; dual specificity protein kinase CLK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:102414)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10585269;21183079;21615147;21750661;36583532;38438604;9307018", "class_list": "", "function": "CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway., [RefSeq, PubMed]; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells., [UniProtKB, PubMed]; MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJU0;Q3UIF5;Q3V463;Q5U4I1;Q8C1V1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001669 acrosomal vesicle;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0046777 protein autophosphorylation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35492-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52431-1", "uniprot_id": [ { "id": "DPOD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52431", "type": "external" } ], "mass": 123790.0, "length": 1105, "protein_name": "DNA polymerase delta catalytic subunit", "gene_name": "Pold1", "organism": "Mouse", "refseq_name": "DNA polymerase delta catalytic subunit", "refseq_ac": [ { "id": "NP_035261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035261", "type": "external" } ], "gene_names_uniprotkb": "Pold1", "gene_names_refseq": "125kDa; Pold1", "protein_names_uniprotkb": "DNA polymerase delta catalytic subunit; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-", "protein_names_refseq": "3'-5' exodeoxyribonuclease; DNA polymerase delta 1, catalytic domain; DNA polymerase delta catalytic subunit", "tax_id": 10090, "disease": "immunodeficiency 120 (Disease Ontology:DOID:0061086); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18971); (R-MMU-110314); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174437); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 19, "publication_count": 6, "publication_id_list": "12429860;21750661;25428506;39627609;8262377;9434960", "class_list": "", "function": "A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner., [RefSeq, PubMed]; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54883;Q3TFX6", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000109 nucleotide-excision repair complex;GO:0043625 delta DNA polymerase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P52431-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZS9-1", "uniprot_id": [ { "id": "DHX32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZS9", "type": "external" } ], "mass": 83941.0, "length": 744, "protein_name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "gene_name": "Dhx32", "organism": "Mouse", "refseq_name": "putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b", "refseq_ac": [ { "id": "NP_001272961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272961", "type": "external" } ], "gene_names_uniprotkb": "Dhx32; Ddx32", "gene_names_refseq": "4732469F02Rik; Ddx32; Dhx32; muDDX32", "protein_names_uniprotkb": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; 3.6.4.13; DEAH box protein 32; MuDDX32", "protein_names_refseq": "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32; DEAH (Asp-Glu-Ala-His) box polypeptide 32; DEAH box protein 32; helicase DDX32; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32", "tax_id": 10090, "disease": "", "pathway": " (mmu:101437)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12163057;17239371;21750661;34428180", "class_list": "", "function": "Electron microscope immunocytochemistry detected the presence of Dhx32 in the mitochondria of hepatocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFU4;Q8VH39;Q922N6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005681 spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BZS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SS80-1", "uniprot_id": [ { "id": "DHR13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SS80", "type": "external" } ], "mass": 40745.0, "length": 376, "protein_name": "Dehydrogenase/reductase SDR family member 13", "gene_name": "Dhrs13", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 13 precursor", "refseq_ac": [ { "id": "NP_899109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899109", "type": "external" } ], "gene_names_uniprotkb": "Dhrs13; Sdr7c5", "gene_names_refseq": "2610209N15Rik; Dhrs13", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 13; 1.1.-.-; Protein SDR7C5; Short chain dehydrogenase/reductase family 7C member 5", "protein_names_refseq": "CGI-82 protein; HCV core-binding protein; androgen-regulated short-chain dehydrogenase/reductase 1; dehydrogenase/reductase (SDR family) member 13; dehydrogenase/reductase SDR family member 13 precursor; likely ortholog of mouse cell line MC/9.IL4 derived transcript 1; prostate short-chain dehydrogenase reductase 1; short chain dehydrogenase/reductase family 7C member 5", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:70451)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;31219806;31599954;34428180", "class_list": "", "function": "Putative oxidoreductase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BH2;Q8BMX8", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5SS80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0L8-1", "uniprot_id": [ { "id": "COG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0L8", "type": "external" } ], "mass": 91391.0, "length": 829, "protein_name": "Conserved oligomeric Golgi complex subunit 5", "gene_name": "Cog5", "organism": "Mouse", "refseq_name": "conserved oligomeric Golgi complex subunit 5", "refseq_ac": [ { "id": "NP_001156598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156598", "type": "external" } ], "gene_names_uniprotkb": "Cog5", "gene_names_refseq": "5430405C01Rik; Cog5; GOLTC1; GTC90", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 5; COG complex subunit 5; Component of oligomeric Golgi complex 5", "protein_names_refseq": "COG complex subunit 5; conserved oligomeric Golgi complex subunit 5", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIi (Disease Ontology:DOID:0070261)", "pathway": " (mmu:238123); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;35820727;36210013", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QM30", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0048219 inter-Golgi cisterna vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0L8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KU1-1", "uniprot_id": [ { "id": "DHDDS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KU1", "type": "external" } ], "mass": 38509.0, "length": 333, "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit Dhdds", "gene_name": "Dhdds", "organism": "Mouse", "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit Dhdds isoform 1", "refseq_ac": [ { "id": "NP_080420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080420", "type": "external" } ], "gene_names_uniprotkb": "Dhdds", "gene_names_refseq": "3222401G21Rik; CIT; DS; Dhdds; HDS; cis-IPTase", "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit Dhdds; 2.5.1.87; CIT; Cis-IPTase; Cis-isoprenyltransferase", "protein_names_refseq": "cis-isoprenyltransferase; dedol-PP synthase; dehydrodolichyl diphosphate synthase complex subunit Dhdds isoform 1; dehydrodolichyl diphosphate synthase complex subunit Dhdds", "tax_id": 10090, "disease": "developmental delay and seizures with or without movement abnormalities (Disease Ontology:DOID:0080473); retinitis pigmentosa 59 (Disease Ontology:DOID:0110352); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67422); (R-MMU-446199)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;32245241;32272552;32526701;34428180;37443173", "class_list": "", "function": "Lack of Overt Retinal Degeneration in a K42E Dhdds Knock-In Mouse Model of RP59. Publication Status: Online-Only, [RefSeq, PubMed]; Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGL4;Q3UF13;Q8BZ16;Q8BZK8", "ec_number_list": [ { "id": "2.5.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.87", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006489 dolichyl diphosphate biosynthetic process;GO:0016094 polyprenol biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KU1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1T8-1", "uniprot_id": [ { "id": "CLC2H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1T8", "type": "external" } ], "mass": 24162.0, "length": 218, "protein_name": "C-type lectin domain family 2 member H", "gene_name": "Clec2h", "organism": "Mouse", "refseq_name": "C-type lectin domain family 2 member H", "refseq_ac": [ { "id": "NP_444395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444395", "type": "external" } ], "gene_names_uniprotkb": "Clec2h; Clrf", "gene_names_refseq": "Clec2h; Clrf; clr-f", "protein_names_uniprotkb": "C-type lectin domain family 2 member H; C-type lectin-related protein F; Clr-f", "protein_names_refseq": "C-type lectin domain family 2 member H; C-type lectin-related protein F", "tax_id": 10090, "disease": "", "pathway": " (mmu:94071)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11398965;21750661;35318366", "class_list": "glycogene", "function": "Clr-f expression regulates kidney immune and metabolic homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q78IZ7;Q924B2", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006968 cellular defense response;GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C1T8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARP9-1", "uniprot_id": [ { "id": "CTSR2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARP9", "type": "external" } ], "mass": 68572.0, "length": 588, "protein_name": "Cation channel sperm-associated protein 2", "gene_name": "Catsper2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Catsper2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cation channel sperm-associated protein 2; CatSper2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:212670); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11675491;14657366;16036917;17174296;17347248;21224844;21412339;21750661;34225353;34998468", "class_list": "", "function": "Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSK0;Q91ZP5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0006816 calcium ion transport;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2ARP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20852-1", "uniprot_id": [ { "id": "CP2A5_MOUSE", "url": "https://www.uniprot.org/uniprot/P20852", "type": "external" } ], "mass": 56741.0, "length": 494, "protein_name": "Cytochrome P450 2A5", "gene_name": "Cyp2a5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp2a5; Cyp2a-5", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2A5; 1.14.14.1; CYPIIA5; Coumarin 7-hydroxylase; Cytochrome P450-15-COH; Cytochrome P450-IIA3.2", "protein_names_refseq": "", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); warfarin resistance (Disease Ontology:DOID:0080665); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (R-MMU-211935); (R-MMU-211981); (R-MMU-211999); (R-MMU-5423646)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10490589;21750661;2703500;2733794;37453647", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases., [UniProtKB, UniProtKB]; Exhibits a high coumarin 7-hydroxylase activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0035634 response to stilbenoid;GO:0071276 cellular response to cadmium ion;GO:0042168 heme metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20852-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05722-1", "uniprot_id": [ { "id": "CO9A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05722", "type": "external" } ], "mass": 92092.0, "length": 921, "protein_name": "Collagen alpha-1(IX) chain", "gene_name": "Col9a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(IX) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_031766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031766", "type": "external" } ], "gene_names_uniprotkb": "Col9a1", "gene_names_refseq": "Col9a-1; Col9a1", "protein_names_uniprotkb": "Collagen alpha-1(IX) chain", "protein_names_refseq": "alpha 1 type IX collagen; collagen alpha-1(IX) chain isoform 1 precursor; collagen alpha-1(IX) chain; procollagen, type IX, alpha 1", "tax_id": 10090, "disease": "multiple epiphyseal dysplasia 6 (Disease Ontology:DOID:0070301); Stickler syndrome (Disease Ontology:DOID:0080046); dilated cardiomyopathy (Disease Ontology:DOID:12930); osteochondrodysplasia (Disease Ontology:DOID:2256); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:12839); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "1690886;2054384;21750661;8061915;8305476", "class_list": "", "function": "Structural component of hyaline cartilage and vitreous of the eye., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61269;Q61270;Q61433;Q61940", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0001894 tissue homeostasis;GO:0001501 skeletal system development;GO:0060349 bone morphogenesis;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05722-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TG9-1", "uniprot_id": [ { "id": "LRFN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TG9", "type": "external" } ], "mass": 84963.0, "length": 788, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 2", "gene_name": "Lrfn2", "organism": "Mouse", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_081728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081728", "type": "external" } ], "gene_names_uniprotkb": "Lrfn2; Kiaa1246; Salm1", "gene_names_refseq": "5730420O05Rik; Lrfn2; SALM1; mKIAA1246", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 2", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:70530); (R-MMU-8849932)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16828986;20485683;29798891;31368584;33481887", "class_list": "", "function": "Data show that SALM1 is a presynaptic organizer of synapse development by promoting F-actin/PIP2-dependent clustering of Neurexin., [RefSeq, PubMed]; Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery., [UniProtKB, PubMed]; These results suggest that SALM1/LRFN2 regulates excitatory synapse function, inhibitory synapse development, social communication, and acoustic startle behavior., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B9EIF8;Q9CYK3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098794 postsynapse;GO:0098793 presynapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80TG9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB16-1", "uniprot_id": [ { "id": "CB39L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB16", "type": "external" } ], "mass": 39106.0, "length": 337, "protein_name": "Calcium-binding protein 39-like", "gene_name": "Cab39l", "organism": "Mouse", "refseq_name": "calcium-binding protein 39-like", "refseq_ac": [ { "id": "NP_081184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081184", "type": "external" } ], "gene_names_uniprotkb": "Cab39l", "gene_names_refseq": "1500031K13Rik; 2810425O13Rik; 4930520C08Rik; Cab39l; MO2L", "protein_names_uniprotkb": "Calcium-binding protein 39-like; MO25beta; Mo25-like protein", "protein_names_refseq": "MO25beta; calcium-binding protein 39-like; mo25-like protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:69008); (R-MMU-380972)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG52;Q91WB8;Q91YL0", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DB16-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29268-1", "uniprot_id": [ { "id": "CCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P29268", "type": "external" } ], "mass": 37824.0, "length": 348, "protein_name": "CCN family member 2", "gene_name": "Ccn2", "organism": "Mouse", "refseq_name": "CCN family member 2 precursor", "refseq_ac": [ { "id": "NP_034347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034347", "type": "external" } ], "gene_names_uniprotkb": "Ccn2; Ctgf; Fisp-12; Fisp12; Hcs24; betaIG-M2", "gene_names_refseq": "Ccn2; Ctgf; Fisp12; Hcs24; fisp-12", "protein_names_uniprotkb": "CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Protein FISP-12", "protein_names_refseq": "CCN family member 2 precursor; CCN family member 2; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); cellular communication network factor 1; fibroblast inducible secreated protein; fibroblast inducible secreted protein; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia, Li-Shao-Li type (Disease Ontology:DOID:0051046); kyphomelic dysplasia (Disease Ontology:DOID:0061155); bone disease (Disease Ontology:DOID:0080001); primary biliary cholangitis (Disease Ontology:DOID:12236); endomyocardial fibrosis (Disease Ontology:DOID:12932); Parkinson's disease (Disease Ontology:DOID:14330); osteochondrodysplasia (Disease Ontology:DOID:2256); ovarian cancer (Disease Ontology:DOID:2394); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); restrictive cardiomyopathy (Disease Ontology:DOID:397); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); aortic valve insufficiency (Disease Ontology:DOID:57); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); tendinitis (Disease Ontology:DOID:971)", "pathway": " (mmu:14219)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10082563;1888698;2029337;21750661;30232710;39414788;9184077", "class_list": "", "function": "Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E830;Q922U0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005938 cell cortex;GO:0031012 extracellular matrix", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29268-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35286-1", "uniprot_id": [ { "id": "DHX15_MOUSE", "url": "https://www.uniprot.org/uniprot/O35286", "type": "external" } ], "mass": 91007.0, "length": 795, "protein_name": "ATP-dependent RNA helicase DHX15", "gene_name": "Dhx15", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DHX15 isoform 2", "refseq_ac": [ { "id": "NP_031865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031865", "type": "external" } ], "gene_names_uniprotkb": "Dhx15; Ddx15; Deah9", "gene_names_refseq": "DBP1; DEAH9; Ddx15; Dhx15; HRH2; mDEAH9", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX15; 3.6.4.13; DEAH box protein 15", "protein_names_refseq": "ATP-dependent RNA helicase DHX15 isoform 2; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A); DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "tax_id": 10090, "disease": "", "pathway": " (mmu:13204); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "21540332;21750661;22645316;24788674;25153642;25428506;26494172;28135057;28528544;30084848;30779550;31219806;33483420;34161762;34428180;34678144;34887587;35820727;38402201;38612527;39627609;9342318", "class_list": "", "function": "Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. Publication Status: Online-Only, [RefSeq, PubMed]; RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:26494172, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (By similarity). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:26494172). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (By similarity). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:26494172, PubMed:34161762, PubMed:34678144). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (PubMed:33483420)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L91", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071014 post-mRNA release spliceosomal complex;GO:0071008 U2-type post-mRNA release spliceosomal complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0006397 mRNA processing;GO:0051607 defense response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O35286-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56542-1", "uniprot_id": [ { "id": "DNS2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P56542", "type": "external" } ], "mass": 38811.0, "length": 353, "protein_name": "Deoxyribonuclease-2-alpha", "gene_name": "Dnase2a; Dnase2", "organism": "Mouse", "refseq_name": "deoxyribonuclease-2-alpha isoform 1 precursor", "refseq_ac": [ { "id": "NP_034192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034192", "type": "external" } ], "gene_names_uniprotkb": "Dnase2a; Dnase2; Dnase2a; Dnl2", "gene_names_refseq": "Dnase2a; Dnase2", "protein_names_uniprotkb": "Deoxyribonuclease-2-alpha; 3.1.22.1; Acid DNase; DNase II alpha; Deoxyribonuclease II alpha; Lysosomal DNase II", "protein_names_refseq": "DNase II alpha; acid DNase; deoxyribonuclease-2-alpha isoform 1 precursor; deoxyribonuclease-2-alpha; lysosomal DNase II", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:13423); (R-MMU-432720)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10903447;11375492;12181746;21750661;23516607;37828378;39095921;9714827", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O55053", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0043277 apoptotic cell clearance;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P56542-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63037-1", "uniprot_id": [ { "id": "DNJA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63037", "type": "external" } ], "mass": 44868.0, "length": 397, "protein_name": "DnaJ homolog subfamily A member 1", "gene_name": "Dnaja1", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily A member 1", "refseq_ac": [ { "id": "NP_001158143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158143", "type": "external" } ], "gene_names_uniprotkb": "Dnaja1; Dnaj2; Hsj2; Hspf4", "gene_names_refseq": "Dnaja1; HSJ-2; Hsj2; Nedd7", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSJ-2; Heat shock 40 kDa protein 4; Heat shock protein J2", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein J2; heat shock protein, Dnaj-like 2; neural precursor cell expressed, developmentally down-regulated gene 7", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:15502); (R-MMU-3371497); (R-MMU-9841251)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14752510;15660130;20363747;21183079;21750661;25153642;28528544;31219806;33972400;34428180;37453647;9799614", "class_list": "", "function": "Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1., [RefSeq, PubMed]; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis., [UniProtKB, PubMed]; Hsc70 and a dimer of DjA1 independently bind to an unfolded protein, [RefSeq, PubMed]; Loss of DjA1 in led to severe defects in spermatogenesis that involve aberrant androgen signaling, [RefSeq, PubMed]; The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P54102", "ec_number_list": [], "go_molecular_function": "GO:0055131 C3HC4-type RING finger domain binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0070585 protein localization to mitochondrion;GO:1903748 negative regulation of establishment of protein localization to mitochondrion;GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63037-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D2J0Y4-1", "uniprot_id": [ { "id": "CJ090_MOUSE", "url": "https://www.uniprot.org/uniprot/D2J0Y4", "type": "external" } ], "mass": 71521.0, "length": 644, "protein_name": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS", "gene_name": "D7Ertd443e", "organism": "Mouse", "refseq_name": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2", "refseq_ac": [ { "id": "NP_001074800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074800", "type": "external" } ], "gene_names_uniprotkb": "D7Ertd443e; Fats", "gene_names_refseq": "4933400E14Rik; D7Ertd443e; FATS; Gm497", "protein_names_uniprotkb": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS; 2.3.2.-; Centrosomal protein C10orf90 homolog; E2/E3 hybrid ubiquitin-protein ligase FATS; FATS; Fragile-site associated tumor suppressor homolog", "protein_names_refseq": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2; (E2-independent) E3 ubiquitin-conjugating enzyme FATS; E2/E3 hybrid ubiquitin-protein ligase FATS; centrosomal protein C10orf90 homolog; fragile-site associated tumor suppressor homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71007)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20154723;20843368;21750661;24240685;25428506;34262035", "class_list": "", "function": "FATS expression was silent or downregulated in human cancers, and overexpression of FATS suppressed tumorigenicity in vivo independently of p53. Results reveal FATS as a p53-regulated gene to monitor genomic stability. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage (PubMed:20154723, PubMed:20843368, PubMed:24240685). Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response (PubMed:24240685). Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). May have a role in the assembly of primary cilia (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0010212 response to ionizing radiation;GO:0030308 negative regulation of cell growth;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D2J0Y4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2V9-1", "uniprot_id": [ { "id": "CCNI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2V9", "type": "external" } ], "mass": 42197.0, "length": 377, "protein_name": "Cyclin-I", "gene_name": "Ccni", "organism": "Mouse", "refseq_name": "cyclin-I", "refseq_ac": [ { "id": "NP_059063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059063", "type": "external" } ], "gene_names_uniprotkb": "Ccni", "gene_names_refseq": "Ccni", "protein_names_uniprotkb": "Cyclin-I", "protein_names_refseq": "cyclin-I", "tax_id": 10090, "disease": "", "pathway": " (mmu:12453)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10072591;11054536;16847066;21750661;22262481;25500740;30084848;34428180", "class_list": "", "function": "Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes., [RefSeq, PubMed]; Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1)., [RefSeq, PubMed]; Subcellular localization of Cdk5 is determined by its specific activators, cyclin I and p35., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X985", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z2V9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A7V7-1", "uniprot_id": [ { "id": "CLM6_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A7V7", "type": "external" } ], "mass": 25336.0, "length": 229, "protein_name": "CMRF35-like molecule 6", "gene_name": "Cd300c", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd300c; Clm6", "gene_names_refseq": "", "protein_names_uniprotkb": "CMRF35-like molecule 6; CD300 antigen-like family member C; CLM-6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:387565)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14662855;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6SJQ2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002376 immune system process;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A7V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LN9-1", "uniprot_id": [ { "id": "DOHH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LN9", "type": "external" } ], "mass": 32905.0, "length": 302, "protein_name": "Deoxyhypusine hydroxylase", "gene_name": "Dohh; Gm48551", "organism": "Mouse", "refseq_name": "deoxyhypusine hydroxylase", "refseq_ac": [ { "id": "NP_598725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598725", "type": "external" } ], "gene_names_uniprotkb": "Dohh; Gm48551", "gene_names_refseq": "1110033C18Rik; Dohh; Hlrc1", "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; DOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase", "protein_names_refseq": "HEAT-like (PBS lyase) repeat containing 1; deoxyhypusine dioxygenase; deoxyhypusine hydroxylase; deoxyhypusine monooxygenase", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:102115); (R-MMU-204626)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;24832488;26037925;31219806;34428180;34688659;37141410", "class_list": "", "function": "An evolutionarily conserved role for the DOHH-mediated second step of hypusine synthesis in early embryonic development, is reported., [RefSeq, PubMed]; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, HAMAP, PubMed, UniProtKB, UniProtKB, UniProtKB]; Deletion of hypusine modification enzymes ( deoxyhypusine synthase and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2-deleted animals are viable and fertile., [RefSeq, PubMed]; Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma., [RefSeq, PubMed]; Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNT3;Q8BTD5", "ec_number_list": [ { "id": "1.14.99.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.29", "type": "external" } ], "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0005506 iron ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008612 peptidyl-lysine modification to peptidyl-hypusine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99LN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF4-1", "uniprot_id": [ { "id": "CLC6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKF4", "type": "external" } ], "mass": 24324.0, "length": 209, "protein_name": "C-type lectin domain family 6 member A", "gene_name": "Clec4n; Clec6a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 6 member A isoform 3", "refseq_ac": [ { "id": "NP_001177250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177250", "type": "external" } ], "gene_names_uniprotkb": "Clec4n; Clec6a; Clec4n; Clecsf10; Dectin2", "gene_names_refseq": "Clec4n; Clec6a; Clecsf10; Nkcl", "protein_names_uniprotkb": "C-type lectin domain family 6 member A; C-type lectin superfamily member 10; DC-associated C-type lectin 2; Dectin-2; Dendritic cell-associated C-type lectin 2", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type lectin domain family 6 member A isoform 3; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin-2; dendritic cell-associated C-type lectin 2; natural killer complex lectin", "tax_id": 10090, "disease": "", "pathway": " (mmu:56620); (R-MMU-5621480); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10766825;17050534;19124755;19703985;20493731;21059925;21750661;32358020;34428180;38331424", "class_list": "glycogene", "function": "Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:17050534, PubMed:19703985, PubMed:20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:17050534, PubMed:19703985, PubMed:20493731, PubMed:32358020). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed:19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed:21059925)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The intestinal commensal fungus Wallemia mellicola enhances asthma in mice through Dectin-2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKF2;Q9JKF3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001878 response to yeast;GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JKF4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ15-1", "uniprot_id": [ { "id": "CLC4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ15", "type": "external" } ], "mass": 27323.0, "length": 238, "protein_name": "C-type lectin domain family 4 member A", "gene_name": "Clec4a2; Clec4a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member A isoform b", "refseq_ac": [ { "id": "NP_001163803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163803", "type": "external" } ], "gene_names_uniprotkb": "Clec4a2; Clec4a; Clec4a2; Clecsf6; Dcir", "gene_names_refseq": "Clec4a2; Clec4a; Clecsf6; DCIR; Dcir1", "protein_names_uniprotkb": "C-type lectin domain family 4 member A; C-type lectin superfamily member 6; Dendritic cell immunoreceptor", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6; C-type lectin domain family 4 member A isoform b; C-type lectin domain family 4 member A; C-type lectin superfamily member 6; dendritic cell immunoreceptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:26888); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10438934;11841542;18204462;19144319;21750661;30899004;34428180;37266426;38532110", "class_list": "glycogene", "function": "C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (By similarity). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:11841542)., [UniProtKB, PubMed, UniProtKB]; DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation., [UniProtKB, PubMed]; The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These observations indicate that Dcir is a negative regulator of dendritic cell expansion and has a crucial role in maintaining the homeostasis of the immune system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 47, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA33", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0036037 CD8-positive, alpha-beta T cell activation;GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0032720 negative regulation of tumor necrosis factor production;GO:0002250 adaptive immune response;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QZ15-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC74-1", "uniprot_id": [ { "id": "COX18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC74", "type": "external" } ], "mass": 36303.0, "length": 331, "protein_name": "Cytochrome c oxidase assembly protein COX18, mitochondrial", "gene_name": "Cox18", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly protein COX18, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001028482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028482", "type": "external" } ], "gene_names_uniprotkb": "Cox18; Oxa1l2", "gene_names_refseq": "Cox18", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX18, mitochondrial", "protein_names_refseq": "COX18 cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly protein COX18, mitochondrial isoform 2; cytochrome c oxidase assembly protein COX18, mitochondrial; mitochondrial inner membrane protein COX18", "tax_id": 10090, "disease": "", "pathway": " (mmu:231430); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;29187734;31219806;34428180", "class_list": "", "function": "Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H626;G3X965;Q3U1D5", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly;GO:0051204 protein insertion into mitochondrial membrane;GO:0032979 protein insertion into mitochondrial inner membrane from matrix;GO:0051205 protein insertion into membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VC74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V76-1", "uniprot_id": [ { "id": "BKGD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V76", "type": "external" } ], "mass": 34996.0, "length": 315, "protein_name": "Beta-keto L-gulonate decarboxylase", "gene_name": "4931406C07Rik; Bkgd", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "4931406C07Rik; Bkgd", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-keto L-gulonate decarboxylase; 4.1.1.34; BKGD", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:70984)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;37453647", "class_list": "", "function": "Catalyzes the decarboxylation of 3-dehydro-L-gulonate to produce L-xylulose, used in the pentose pathway (By similarity). Exhibits ester hydrolase activity on p-nitrophenyl acetate, in vitro (By similarity). Regulates DNA damage and repair by regulating HIF1A degradation via chaperone-mediated autophagy (CMA) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0047842 dehydro-L-gulonate decarboxylase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91V76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVD4-1", "uniprot_id": [ { "id": "CLCN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVD4", "type": "external" } ], "mass": 90706.0, "length": 816, "protein_name": "H(+)/Cl(-) exchange transporter 5", "gene_name": "Clcn5", "organism": "Mouse", "refseq_name": "H(+)/Cl(-) exchange transporter 5 isoform 1", "refseq_ac": [ { "id": "NP_057900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057900", "type": "external" } ], "gene_names_uniprotkb": "Clcn5; Clc5", "gene_names_refseq": "5430408K11Rik; ClC-5; Clc4-1; Clc5; Clcn4-1; Clcn5; D930009B12Rik; DXImx42e; Sfc13", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; Chloride transporter ClC-5; ClC-5", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 5 isoform 1; chloride channel 4-1; chloride channel 5; chloride channel protein 5; chloride transporter ClC-5; h(+)/Cl(-) exchange transporter 5", "tax_id": 10090, "disease": "Dent disease (Disease Ontology:DOID:0050699); X-linked recessive hypophosphatemic rickets (Disease Ontology:DOID:0080353); Dent disease 1 (Disease Ontology:DOID:0081453); X-linked nephrolithiasis type I (Disease Ontology:DOID:0111798); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (mmu:12728); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10373326;21750661;27802388;36336066", "class_list": "", "function": "Identification of an Electrogenic 2Cl[-]/H[+] Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis., [RefSeq, PubMed]; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATV0;B1AXN0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0006821 chloride transport;GO:0003014 renal system process;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAE7-1", "uniprot_id": [ { "id": "CK097_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAE7", "type": "external" } ], "mass": 13565.0, "length": 121, "protein_name": "Uncharacterized protein C11orf97 homolog", "gene_name": "1700012B09Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf97 homolog", "refseq_ac": [ { "id": "NP_083582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083582", "type": "external" } ], "gene_names_uniprotkb": "1700012B09Rik", "gene_names_refseq": "1700007P19Rik; 1700012B09Rik", "protein_names_uniprotkb": "Uncharacterized protein C11orf97 homolog", "protein_names_refseq": "uncharacterized protein C11orf97 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69325)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;21750661;27914912;28666954", "class_list": "", "function": "1700012B09RIK protein localises to basal bodies of cilia in cultured cells., [RefSeq, PubMed]; 1700012B09Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTE5-1", "uniprot_id": [ { "id": "CEBOS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTE5", "type": "external" } ], "mass": 9286.0, "length": 80, "protein_name": "Protein CEBPZOS", "gene_name": "Cebpzos", "organism": "Mouse", "refseq_name": "protein CEBPZOS", "refseq_ac": [ { "id": "NP_001170873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170873", "type": "external" } ], "gene_names_uniprotkb": "Cebpzos", "gene_names_refseq": "1110001A16Rik; Cebpzos", "protein_names_uniprotkb": "Protein CEBPZOS", "protein_names_refseq": "CCAAT/enhancer binding protein (C/EBP), zeta, opposite strand; protein CEBPZOS", "tax_id": 10090, "disease": "", "pathway": " (mmu:68554)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031966 mitochondrial membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BTE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWX2-1", "uniprot_id": [ { "id": "CIA30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWX2", "type": "external" } ], "mass": 37810.0, "length": 328, "protein_name": "Complex I intermediate-associated protein 30, mitochondrial", "gene_name": "Ndufaf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndufaf1; Cia30", "gene_names_refseq": "", "protein_names_uniprotkb": "Complex I intermediate-associated protein 30, mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 11 (Disease Ontology:DOID:0112089); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:69702); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEI8", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CWX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7D7-1", "uniprot_id": [ { "id": "CLD23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7D7", "type": "external" } ], "mass": 32461.0, "length": 296, "protein_name": "Claudin-23", "gene_name": "Cldn23", "organism": "Mouse", "refseq_name": "claudin-23", "refseq_ac": [ { "id": "NP_082274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082274", "type": "external" } ], "gene_names_uniprotkb": "Cldn23", "gene_names_refseq": "2310014B08Rik; Cldn23", "protein_names_uniprotkb": "Claudin-23", "protein_names_refseq": "claudin-23", "tax_id": 10090, "disease": "atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:71908)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12736707;21750661;37798277", "class_list": "", "function": "Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; Report on identification and characterization of human CLDN23., [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and the protein encoded by this gene is 77% identical to the human homolog. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0120193 tight junction organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7D7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WD4-1", "uniprot_id": [ { "id": "CG025_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WD4", "type": "external" } ], "mass": 46541.0, "length": 421, "protein_name": "UPF0415 protein C7orf25 homolog", "gene_name": "AW209491", "organism": "Mouse", "refseq_name": "UPF0415 protein C7orf25 homolog", "refseq_ac": [ { "id": "NP_001098116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098116", "type": "external" } ], "gene_names_uniprotkb": "AW209491", "gene_names_refseq": "AW209491", "protein_names_uniprotkb": "UPF0415 protein C7orf25 homolog", "protein_names_refseq": "UPF0415 protein C7orf25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:105351)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP59;Q8BSU5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4D7-1", "uniprot_id": [ { "id": "CC50C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4D7", "type": "external" } ], "mass": 38604.0, "length": 342, "protein_name": "Cell cycle control protein 50C", "gene_name": "Tmem30c", "organism": "Mouse", "refseq_name": "cell cycle control protein 50C", "refseq_ac": [ { "id": "NP_081927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081927", "type": "external" } ], "gene_names_uniprotkb": "Tmem30c; Cdc50c", "gene_names_refseq": "4933401B01Rik; 4933409A18Rik; Cdc50c; Tmem30c", "protein_names_uniprotkb": "Cell cycle control protein 50C; Transmembrane protein 30C", "protein_names_refseq": "cell cycle control protein 50C; transmembrane protein 30C", "tax_id": 10090, "disease": "", "pathway": " (mmu:71027)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17258408;17928922;21750661;25428506", "class_list": "", "function": "MRNA localized in pachytene spermatocytes and round and elongated spermatids; involved in spermatogenesis. [Cdc50c], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A9C447", "ec_number_list": [], "go_molecular_function": "GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D4D7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8Y0-1", "uniprot_id": [ { "id": "CF161_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8Y0", "type": "external" } ], "mass": 34388.0, "length": 303, "protein_name": "Cilia- and flagella-associated protein 161", "gene_name": "Cfap161", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 161", "refseq_ac": [ { "id": "NP_083611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083611", "type": "external" } ], "gene_names_uniprotkb": "Cfap161; 1700026D08Rik", "gene_names_refseq": "1700026D08Rik; Cfap161", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 161", "protein_names_refseq": "cilia- and flagella-associated protein 161", "tax_id": 10090, "disease": "", "pathway": " (mmu:75556)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;21750661;37295417;37865089;37989994", "class_list": "", "function": "1700026D08Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9X1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0044458 motile cilium assembly;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P8Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Q7-1", "uniprot_id": [ { "id": "CERK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4Q7", "type": "external" } ], "mass": 59843.0, "length": 531, "protein_name": "Ceramide kinase", "gene_name": "Cerk", "organism": "Mouse", "refseq_name": "ceramide kinase", "refseq_ac": [ { "id": "NP_663450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663450", "type": "external" } ], "gene_names_uniprotkb": "Cerk", "gene_names_refseq": "Cerk; D330016D08Rik; mKIAA1646", "protein_names_uniprotkb": "Ceramide kinase; 2.7.1.138; Acylsphingosine kinase; mCERK", "protein_names_refseq": "acylsphingosine kinase; ceramide kinase; mCERK", "tax_id": 10090, "disease": "", "pathway": " (mmu:223753); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11956206;16269826;17888878;21750661;25428506;26740625;30084848;31219806;32056304;34428180;35245521;35926944;36210013;38556546", "class_list": "glycogene", "function": "Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:16269826). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:16269826). Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity)., [UniProtKB, UniProtKB, PubMed]; Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice., [RefSeq, PubMed]; Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2., [RefSeq, PubMed]; Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality., [RefSeq, PubMed]; Findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion., [RefSeq, PubMed]; MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KP2", "ec_number_list": [ { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0001729 ceramide kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0160281 cytoplasmic side of trans-Golgi network membrane", "go_biological_process": "GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K4Q7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQB5-1", "uniprot_id": [ { "id": "CISD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQB5", "type": "external" } ], "mass": 15242.0, "length": 135, "protein_name": "CDGSH iron-sulfur domain-containing protein 2", "gene_name": "Cisd2", "organism": "Mouse", "refseq_name": "CDGSH iron-sulfur domain-containing protein 2", "refseq_ac": [ { "id": "NP_080178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080178", "type": "external" } ], "gene_names_uniprotkb": "Cisd2; Cdgsh2; Noxp70; Zcd2", "gene_names_refseq": "1500009M05Rik; 1500026J14Rik; 1500031D15Rik; B630006A20Rik; Cisd2; Miner1; Naf-1; Noxp70; Zcd2", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 2; Miner1; MitoNEET-related 1 protein; Nervous system overexpressed protein 70", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 2; mitoNEET-related 1 protein; nervous system over-expressed protein 70; nervous system overexpressed protein 70; nutrient-deprivation autophagy factor-1; zinc finger, CDGSH-type domain 2", "tax_id": 10090, "disease": "Wolfram syndrome 2 (Disease Ontology:DOID:0110630)", "pathway": " (mmu:67006)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17029606;19451219;20649540;21750661;22343142;34428180;38627949", "class_list": "", "function": "CISD2 has a role in lifespan control and disease [review] Review article, [RefSeq, PubMed]; Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA., [RefSeq, PubMed]; Cisd2 deficiency in mice causes mitochondrial breakdown and dysfunction accompanied by autophagic cell death, and these precede nerve and muscle degeneration; together, they lead to a panel of phenotypic features suggestive of premature aging, [RefSeq, PubMed]; NAF-1, a BCL-2-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle, [RefSeq, PubMed]; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0Y0", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQB5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9P2-1", "uniprot_id": [ { "id": "DAA19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9P2", "type": "external" } ], "mass": 26861.0, "length": 237, "protein_name": "Dynein axonemal assembly factor 19", "gene_name": "Ccdc103; Dnaaf19", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 19 isoform 1", "refseq_ac": [ { "id": "NP_082768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082768", "type": "external" } ], "gene_names_uniprotkb": "Ccdc103; Dnaaf19; Ccdc103", "gene_names_refseq": "1700039D13Rik; Ccdc103; Dnaaf19", "protein_names_uniprotkb": "Dynein axonemal assembly factor 19; Coiled-coil domain-containing protein 103", "protein_names_refseq": "coiled-coil domain containing 103; coiled-coil domain-containing protein 103; dynein axonemal assembly factor 19 isoform 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia 17 (Disease Ontology:DOID:0110621); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:73293)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "Dynein-attachment factor required for cilia motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AH86", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031514 motile cilium;GO:0036157 outer dynein arm", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0036158 outer dynein arm assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9P2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHB9-1", "uniprot_id": [ { "id": "CLIC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHB9", "type": "external" } ], "mass": 62886.0, "length": 596, "protein_name": "Chloride intracellular channel protein 6", "gene_name": "Clic6", "organism": "Mouse", "refseq_name": "chloride intracellular channel protein 6", "refseq_ac": [ { "id": "NP_766057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766057", "type": "external" } ], "gene_names_uniprotkb": "Clic6", "gene_names_refseq": "5730466J16Rik; CLIC1L; Clic6", "protein_names_uniprotkb": "Chloride intracellular channel protein 6; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC6", "protein_names_refseq": "chloride intracellular channel protein 6; glutaredoxin-like oxidoreductase CLIC6", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:209195)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14597386;21750661;29720717;37838179", "class_list": "", "function": "Biophysical characterization of chloride intracellular channel 6 (CLIC6)., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (By similarity). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0031751 D4 dopamine receptor binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity;GO:0031749 D2 dopamine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0009913 epidermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BHB9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQX5-1", "uniprot_id": [ { "id": "CLDN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQX5", "type": "external" } ], "mass": 28572.0, "length": 253, "protein_name": "Claudin domain-containing protein 1", "gene_name": "Cldnd1", "organism": "Mouse", "refseq_name": "claudin domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_741968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741968", "type": "external" } ], "gene_names_uniprotkb": "Cldnd1; Cldn25; D11Moh34", "gene_names_refseq": "1110019C08Rik; Cldn25; Cldnd1; claudin-25", "protein_names_uniprotkb": "Claudin domain-containing protein 1; Claudin-25", "protein_names_refseq": "claudin 25; claudin domain-containing protein 1 isoform 1; claudin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224250)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21276448;21750661;28244141;30899004;34428180", "class_list": "", "function": "Plays a role in negatively regulating the permeability of cells to small molecules., [UniProtKB, PubMed]; Suggest that the transient decrease of CLDND1 after cerebellar hemorrhage is responsible for low-molecular-weight selective vascular hyperpermeability, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7C4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CQX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1X9-1", "uniprot_id": [ { "id": "CDC45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1X9", "type": "external" } ], "mass": 65384.0, "length": 566, "protein_name": "Cell division control protein 45 homolog", "gene_name": "Cdc45", "organism": "Mouse", "refseq_name": "cell division control protein 45 homolog isoform 1", "refseq_ac": [ { "id": "NP_033992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033992", "type": "external" } ], "gene_names_uniprotkb": "Cdc45; Cdc45l2; Cdc45l", "gene_names_refseq": "Cdc45l; Cdc45", "protein_names_uniprotkb": "Cell division control protein 45 homolog; PORC-PI-1", "protein_names_refseq": "CDC45-related protein; PORC-PI-1; cell division control protein 45 homolog isoform 1; cell division control protein 45 homolog; cell division cycle 45 homolog", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); Meier-Gorlin syndrome 7 (Disease Ontology:DOID:0080518)", "pathway": " (mmu:12544); (R-MMU-176187); (R-MMU-68962)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10051334;21183079;21750661;25428506;31219806;37781960;9724329", "class_list": "", "function": "DONSON is required for CMG helicase assembly in the mammalian cell cycle., [RefSeq, PubMed]; Required for initiation of chromosomal DNA replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70547;Q9QUK1;Q9R212", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902977 mitotic DNA replication preinitiation complex assembly;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1X9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XD9-1", "uniprot_id": [ { "id": "CLC2E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XD9", "type": "external" } ], "mass": 22754.0, "length": 204, "protein_name": "C-type lectin domain family 2 member E", "gene_name": "Clec2e", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clec2e; Clra", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 2 member E; C-type lectin-related protein A; Clr-a", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:232409); (R-MMU-198933)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11398965;21750661", "class_list": "glycogene", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI18", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80XD9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U462-1", "uniprot_id": [ { "id": "CDCP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U462", "type": "external" } ], "mass": 92726.0, "length": 833, "protein_name": "CUB domain-containing protein 1", "gene_name": "Cdcp1", "organism": "Mouse", "refseq_name": "CUB domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_598735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598735", "type": "external" } ], "gene_names_uniprotkb": "Cdcp1", "gene_names_refseq": "9030022E12Rik; Cdcp1; E030027H19Rik", "protein_names_uniprotkb": "CUB domain-containing protein 1; Membrane glycoprotein gp140; Transmembrane and associated with src kinases", "protein_names_refseq": "CUB domain-containing protein 1 precursor; membrane glycoprotein gp140; transmembrane and associated with src kinases", "tax_id": 10090, "disease": "", "pathway": " (mmu:109332)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;18483259;22179830;34099547;35951427;36593286", "class_list": "", "function": "CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression. Erratum:[Sci Rep. 2023 Feb 17;13(1):2838. doi: 10.1038/s41598-023-28942-0. PMID: 36801926] Publication Status: Online-Only, [RefSeq, PubMed]; CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model, [RefSeq, PubMed]; CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease., [RefSeq, PubMed]; CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis. Publication Status: Online-Only, [RefSeq, PubMed]; Established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis, [RefSeq, PubMed]; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q810J0;Q921M9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035728 response to hepatocyte growth factor;GO:0008283 cell population proliferation;GO:0045184 establishment of protein localization;GO:0023052 signaling;GO:0048012 hepatocyte growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q5U462-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640L3-1", "uniprot_id": [ { "id": "CCPG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640L3", "type": "external" } ], "mass": 86126.0, "length": 753, "protein_name": "Cell cycle progression protein 1", "gene_name": "Ccpg1", "organism": "Mouse", "refseq_name": "cell cycle progression protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001107800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107800", "type": "external" } ], "gene_names_uniprotkb": "Ccpg1", "gene_names_refseq": "1700030B06Rik; 1810073J13Rik; 9430028F23Rik; CPR8; Ccpg1; D9Ertd392e", "protein_names_uniprotkb": "Cell cycle progression protein 1", "protein_names_refseq": "cell cycle progression 8 protein; cell cycle progression protein 1 isoform 1; cell cycle progression protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72278)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17000758;17242355;21750661;31219806;34418053;34428180", "class_list": "", "function": "Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05BJ9;Q8C692;Q922W9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q640L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64285-1", "uniprot_id": [ { "id": "CEL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64285", "type": "external" } ], "mass": 65813.0, "length": 599, "protein_name": "Bile salt-activated lipase", "gene_name": "Cel", "organism": "Mouse", "refseq_name": "bile salt-activated lipase precursor", "refseq_ac": [ { "id": "NP_034015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034015", "type": "external" } ], "gene_names_uniprotkb": "Cel; Lip1", "gene_names_refseq": "1810036E18Rik; BAL; BSSL; Cel", "protein_names_uniprotkb": "Bile salt-activated lipase; 3.1.1.13; 3.1.1.3; 3.1.1.6; BAL; BSSL; Bile salt-stimulated lipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase", "protein_names_refseq": "bile salt-activated lipase precursor; bile salt-activated lipase; bile salt-stimulated lipase; cholesterol esterase; pancreatic lysophospholipase; sterol esterase", "tax_id": 10090, "disease": "maturity-onset diabetes of the young type 8 (Disease Ontology:DOID:0111105); lipomatosis (Disease Ontology:DOID:3153); pancreatitis (Disease Ontology:DOID:4989); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12613); (R-MMU-192456)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11834744;27509211;30954473;35398595;8522186;8530060", "class_list": "glycogene", "function": "Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis., [RefSeq, PubMed]; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:27509211). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (PubMed:27509211). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity)., [UniProtKB, PubMed, UniProtKB]; The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0004771 sterol ester esterase activity;GO:0044877 protein-containing complex binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046514 ceramide catabolic process;GO:0030299 intestinal cholesterol absorption;GO:0030157 pancreatic juice secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64285-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64676-1", "uniprot_id": [ { "id": "CGT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64676", "type": "external" } ], "mass": 61249.0, "length": 541, "protein_name": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase", "gene_name": "Ugt8", "organism": "Mouse", "refseq_name": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform 1 precursor", "refseq_ac": [ { "id": "NP_035804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035804", "type": "external" } ], "gene_names_uniprotkb": "Ugt8; Cgt; Ugt4; Ugt8a", "gene_names_refseq": "Cgt; Ugt8a; Ugt8; mCerGT", "protein_names_uniprotkb": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase; 2.4.1.47; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase", "protein_names_refseq": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform 1 precursor; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; ceramide UDP-galactosyltransferase; cerebroside synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:22239); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;30899004;40885482;8661123;8661124", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61634;Q91W57", "ec_number_list": [ { "id": "2.4.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.47", "type": "external" } ], "go_molecular_function": "GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0003851 N-acylsphingosine galactosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0007010 cytoskeleton organization;GO:0030913 paranodal junction assembly;GO:0035902 response to immobilization stress;GO:0006682 galactosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q64676-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P2K3-1", "uniprot_id": [ { "id": "CF20D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P2K3", "type": "external" } ], "mass": 75131.0, "length": 674, "protein_name": "Protein CFAP20DC", "gene_name": "Cfap20dc", "organism": "Mouse", "refseq_name": "protein CFAP20DC", "refseq_ac": [ { "id": "NP_083210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083210", "type": "external" } ], "gene_names_uniprotkb": "Cfap20dc", "gene_names_refseq": "4930452B06Rik; 4933406L09Rik; Cfap20dc", "protein_names_uniprotkb": "Protein CFAP20DC", "protein_names_refseq": "protein CFAP20DC; uncharacterized protein C3orf67 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK14", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P2K3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLQ4-1", "uniprot_id": [ { "id": "CLC7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6QLQ4", "type": "external" } ], "mass": 27420.0, "length": 244, "protein_name": "C-type lectin domain family 7 member A", "gene_name": "Clec7a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clec7a; Bgr; Clecsf12; Dectin1", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 7 member A; Beta-glucan receptor; C-type lectin superfamily member 12; DC-associated C-type lectin 1; Dectin-1; Dendritic cell-associated C-type lectin 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "aspergillosis (Disease Ontology:DOID:13564); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058)", "pathway": " (mmu:56644); (R-MMU-5607764)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10779524;11544516;12719479;15213161;15729357;15731053;15845454;16825490;17159984;17473009;21750661;26740625;27288407;32358020", "class_list": "glycogene", "function": "Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11544516, PubMed:15213161, PubMed:17159984). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:12719479, PubMed:15731053, PubMed:16825490, PubMed:32358020). Enhances cytokine production in macrophages and dendritic cells (PubMed:15845454). Mediates production of reactive oxygen species in the cell (PubMed:12719479, PubMed:15731053, PubMed:16825490). Mediates phagocytosis of C.albicans conidia (PubMed:15729357, PubMed:16825490). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation (PubMed:10779524). Stimulates T-cell proliferation (PubMed:10779524). Induces phosphorylation of SCIMP after binding beta-glucans (PubMed:27288407)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPW2;Q8K1L4;Q9JI50", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0001872 (1->3)-beta-D-glucan binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002366 leukocyte activation involved in immune response;GO:0032747 positive regulation of interleukin-23 production;GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0016046 detection of fungus;GO:0001878 response to yeast", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6QLQ4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG31-1", "uniprot_id": [ { "id": "VEXIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG31", "type": "external" } ], "mass": 22491.0, "length": 207, "protein_name": "Vexin", "gene_name": "Vxn", "organism": "Mouse", "refseq_name": "vexin", "refseq_ac": [ { "id": "NP_848486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848486", "type": "external" } ], "gene_names_uniprotkb": "Vxn", "gene_names_refseq": "3110035E14Rik; Vxn", "protein_names_uniprotkb": "Vexin", "protein_names_refseq": "uncharacterized protein C8orf46 homolog; vexin", "tax_id": 10090, "disease": "", "pathway": " (mmu:76982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29518376", "class_list": "", "function": "Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis (PubMed:29518376)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030182 neuron differentiation;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGZ4-1", "uniprot_id": [ { "id": "CDC23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGZ4", "type": "external" } ], "mass": 68562.0, "length": 597, "protein_name": "Cell division cycle protein 23 homolog", "gene_name": "Cdc23", "organism": "Mouse", "refseq_name": "cell division cycle protein 23 homolog", "refseq_ac": [ { "id": "NP_848124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848124", "type": "external" } ], "gene_names_uniprotkb": "Cdc23; Anapc8", "gene_names_refseq": "6030435O18; Cdc23; D18Ertd243e", "protein_names_uniprotkb": "Cell division cycle protein 23 homolog; APC8; Anaphase-promoting complex subunit 8; Cyclosome subunit 8", "protein_names_refseq": "APC8; CDC23 (cell division cycle 23, yeast, homolog); anaphase-promoting complex subunit 8; cell division cycle protein 23 homolog; cyclosome subunit 8", "tax_id": 10090, "disease": "infertility (Disease Ontology:DOID:5223)", "pathway": " (mmu:52563); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 11, "publication_id_list": "15345747;17242355;21183079;21750661;31219806;32449168;32782141;34428180;35820727;37507081;37768355", "class_list": "", "function": "Cell division cycle 23 is required for mouse oocyte meiotic maturation., [RefSeq, PubMed]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PD06;Q8C0F1", "ec_number_list": [], "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BGZ4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI06-1", "uniprot_id": [ { "id": "CEMIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI06", "type": "external" } ], "mass": 153034.0, "length": 1361, "protein_name": "Cell migration-inducing and hyaluronan-binding protein", "gene_name": "Cemip", "organism": "Mouse", "refseq_name": "cell migration-inducing and hyaluronan-binding protein precursor", "refseq_ac": [ { "id": "NP_109653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109653", "type": "external" } ], "gene_names_uniprotkb": "Cemip; Hybid; Kiaa1199", "gene_names_refseq": "12H19.01.T7; 6330404C01Rik; 9930013L23Rik; Cemip; Hybid; Kiaa1199", "protein_names_uniprotkb": "Cell migration-inducing and hyaluronan-binding protein; 3.2.1.35; Hyaluronan binding protein involved in hyaluronan depolymerization; Protein 12H19.01.T7", "protein_names_refseq": "cell migration-inducing and hyaluronan-binding protein precursor; cell migration-inducing and hyaluronan-binding protein; hyaluronan binding protein involved in hyaluronan depolymerization; protein 12H19.01.T7", "tax_id": 10090, "disease": "", "pathway": " (mmu:80982); (R-MMU-2160916)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11247670;14577002;18448257;24251095;35405271;35474501;37037828", "class_list": "glycogene;glycosylhydrolase", "function": "CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane. Publication Status: Online-Only, [RefSeq, PubMed]; KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing., [UniProtKB, PubMed]; Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 76, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QJS6;Q6L9J4;Q9EPQ3;Q9EPQ4", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding;GO:0004415 hyalurononglucosaminidase activity;GO:0032050 clathrin heavy chain binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0030335 positive regulation of cell migration;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0007605 sensory perception of sound;GO:0090314 positive regulation of protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BI06-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5T8-1", "uniprot_id": [ { "id": "CF263_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5T8", "type": "external" } ], "mass": 44215.0, "length": 377, "protein_name": "Cilia- and flagella-associated protein 263", "gene_name": "Cfap263", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 263", "refseq_ac": [ { "id": "NP_766502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766502", "type": "external" } ], "gene_names_uniprotkb": "Cfap263; Ccdc113", "gene_names_refseq": "4933409I22; Ccdc113; Cfap263", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 263", "protein_names_refseq": "cilia- and flagella-associated protein 263; coiled-coil domain containing 113; coiled-coil domain-containing protein 113", "tax_id": 10090, "disease": "", "pathway": " (mmu:244608)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17971504", "class_list": "", "function": "Ccdc113 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Component of centriolar satellites contributing to primary cilium formation (By similarity). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBW7-1", "uniprot_id": [ { "id": "CHIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBW7", "type": "external" } ], "mass": 25791.0, "length": 227, "protein_name": "Cysteine-rich hydrophobic domain-containing protein 1", "gene_name": "Chic1", "organism": "Mouse", "refseq_name": "cysteine-rich hydrophobic domain-containing protein 1", "refseq_ac": [ { "id": "NP_033897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033897", "type": "external" } ], "gene_names_uniprotkb": "Chic1; Brx", "gene_names_refseq": "Brx; Chic1; Gm10454", "protein_names_uniprotkb": "Cysteine-rich hydrophobic domain-containing protein 1; Brain X-linked protein", "protein_names_refseq": "brain X-linked protein; cysteine-rich hydrophobic domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12212)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12045143;19211510;9321471", "class_list": "", "function": "Brx is essential for the expression of nfat5 in response to osmotic stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08904;Q8K3S5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CBW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDN8-1", "uniprot_id": [ { "id": "CCD38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDN8", "type": "external" } ], "mass": 65835.0, "length": 563, "protein_name": "Coiled-coil domain-containing protein 38", "gene_name": "Ccdc38", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 38 isoform 1", "refseq_ac": [ { "id": "NP_780697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780697", "type": "external" } ], "gene_names_uniprotkb": "Ccdc38", "gene_names_refseq": "4933417K05Rik; Ccdc38", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 38", "protein_names_refseq": "coiled-coil domain-containing protein 38 isoform 1; coiled-coil domain-containing protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:237465)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "27278724;35587122;37709195;38038747", "class_list": "", "function": "CCDC38 is required for sperm flagellum biogenesis and male fertility in mice., [RefSeq, PubMed]; Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice., [RefSeq, PubMed]; Essential for male fertility (PubMed:35587122, PubMed:37709195). Required for sperm flagellum biogenesis (PubMed:35587122, PubMed:37709195). Also required for acrosome biogenesis (PubMed:37709195). Required for the attachment of developing acrosomes to the nucleus during spermiogenesis and may be involved in the transport of fibrous sheath components (PubMed:37709195)., [UniProtKB, PubMed, PubMed]; These results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDD6;Q8CDE1", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0001675 acrosome assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CDN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDT7-1", "uniprot_id": [ { "id": "CBCO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDT7", "type": "external" } ], "mass": 24087.0, "length": 208, "protein_name": "Ciliary-associated calcium-binding coiled-coil protein 1", "gene_name": "Cabcoco1", "organism": "Mouse", "refseq_name": "ciliary-associated calcium-binding coiled-coil protein 1", "refseq_ac": [ { "id": "NP_082767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082767", "type": "external" } ], "gene_names_uniprotkb": "Cabcoco1; 1700040L02Rik", "gene_names_refseq": "1700040L02Rik; Cabcoco1", "protein_names_uniprotkb": "Ciliary-associated calcium-binding coiled-coil protein 1", "protein_names_refseq": "ciliary-associated calcium-binding coiled-coil protein 1; uncharacterized protein C10orf107 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73287)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;21750661;26990073", "class_list": "", "function": "1700040L02Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Calcium-binding protein (PubMed:26990073). May be involved in the control of sperm flagellar movement (PubMed:26990073)., [UniProtKB, PubMed]; These results suggested that CABCOCO1 is involved in the control of sperm flagellar movement., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0036126 sperm flagellum", "go_biological_process": "GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CDT7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBX4-1", "uniprot_id": [ { "id": "CLC4K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBX4", "type": "external" } ], "mass": 37621.0, "length": 331, "protein_name": "C-type lectin domain family 4 member K", "gene_name": "Cd207", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member K", "refseq_ac": [ { "id": "NP_659192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659192", "type": "external" } ], "gene_names_uniprotkb": "Cd207; Clec4k", "gene_names_refseq": "Cd207", "protein_names_uniprotkb": "C-type lectin domain family 4 member K; Langerin", "protein_names_refseq": "C-type lectin domain family 4 member K; Langerhans cell specific c-type lectin; langerin", "tax_id": 10090, "disease": "", "pathway": " (mmu:246278); (R-MMU-1236978)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11777972;11978773;15191546;18322168;26495903;27903635;28011936;35984892;37813655", "class_list": "glycogene", "function": "Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells., [UniProtKB, PubMed, PubMed]; Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated., [RefSeq, PubMed]; Molecular cloning and expression of Langerin transcripts in dendritic cells Erratum:[Int Immunol. 2002 Jul;14(7):831. Clusen, Bjoern [corrected to Clausen, Bjorn E]], [RefSeq, PubMed]; [Study the involvement of Langerin in mediating epicutaneous sensitization of atopic dermatitis-like mouse model]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R442", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VBX4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCN5-1", "uniprot_id": [ { "id": "CGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCN5", "type": "external" } ], "mass": 43567.0, "length": 398, "protein_name": "Cystathionine gamma-lyase", "gene_name": "Cth", "organism": "Mouse", "refseq_name": "cystathionine gamma-lyase", "refseq_ac": [ { "id": "NP_666065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666065", "type": "external" } ], "gene_names_uniprotkb": "Cth", "gene_names_refseq": "0610010I13Rik; CGL; CSE; Cth; Cys3", "protein_names_uniprotkb": "Cystathionine gamma-lyase; 4.4.1.1; 4.4.1.2; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase", "protein_names_refseq": "cystathionase (cystathionine gamma-lyase); cystathionine gamma-lyase; cysteine desulfhydrase; cysteine-protein sulfhydrase; homocysteine desulfhydrase", "tax_id": 10090, "disease": "cystathioninuria (Disease Ontology:DOID:0090142); cataract (Disease Ontology:DOID:83); amino acid metabolic disorder (Disease Ontology:DOID:9252); homocystinuria (Disease Ontology:DOID:9263)", "pathway": " (mmu:107869); (R-MMU-1614558); (R-MMU-1614603)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15038791;16327076;17488480;17853447;18948540;19903941;20305127;22244329;33826201;34428180;37453647", "class_list": "", "function": "Caerulein increased the level of cystathionine gamma-Lyase., [RefSeq, PubMed]; Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (By similarity). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:19903941, PubMed:22244329). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity) (PubMed:18948540). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (PubMed:33826201). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Study shows H2S is physiologically generated by cystathionine gamma-lyase (CSE) & genetic deletion CSE markedly reduces H2S levels in serum & tissue; mice lacking CSE display pronounced hypertension & diminished endothelium-dependent vasorelaxation, [RefSeq, PubMed]; Te CGL antiserum recognized the correct molecular weight protein for mouse retina., [RefSeq, PubMed]; The purpose of this study was to identify the seleno-L-methionine (L-SeMet) alpha,gamma-elimination enzyme that catalyzes L-SeMet to generate methylselenol (CH3SeH), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6H324", "ec_number_list": [ { "id": "4.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.1", "type": "external" }, { "id": "4.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004123 cystathionine gamma-lyase activity;GO:0044540 L-cystine L-cysteine-lyase (deaminating)", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051289 protein homotetramerization;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8VCN5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD62-2", "uniprot_id": [ { "id": "CK068_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD62", "type": "external" } ], "mass": 31846.0, "length": 298, "protein_name": "UPF0696 protein C11orf68 homolog", "gene_name": "Bles03", "organism": "Mouse", "refseq_name": "UPF0696 protein C11orf68 homolog isoform b", "refseq_ac": [ { "id": "NP_001243444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243444", "type": "external" } ], "gene_names_uniprotkb": "Bles03", "gene_names_refseq": "AI837181; Bles03", "protein_names_uniprotkb": "UPF0696 protein C11orf68 homolog; Basophilic leukemia-expressed protein Bles03; Protein WF-3", "protein_names_refseq": "UPF0696 protein C11orf68 homolog isoform b; UPF0696 protein C11orf68 homolog; basophilic leukemia expressed protein; basophilic leukemia-expressed protein Bles03; protein WF-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:107242)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16511166;24129315;37507081", "class_list": "", "function": "Structural characterization of the human ortholog., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNR6;Q6LCE3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VD62-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEH6-1", "uniprot_id": [ { "id": "ZNG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEH6", "type": "external" } ], "mass": 43772.0, "length": 393, "protein_name": "Zinc-regulated GTPase metalloprotein activator 1", "gene_name": "Zng1", "organism": "Mouse", "refseq_name": "zinc-regulated GTPase metalloprotein activator 1", "refseq_ac": [ { "id": "NP_666209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666209", "type": "external" } ], "gene_names_uniprotkb": "Zng1; Cbwd1", "gene_names_refseq": "Cbwd1; Zng1", "protein_names_uniprotkb": "Zinc-regulated GTPase metalloprotein activator 1; 3.6.5.-; COBW domain-containing protein 1; Cobalamin synthase W domain-containing protein 1", "protein_names_refseq": "COBW domain containing 1; COBW domain-containing protein 1; cobalamin synthase W domain-containing protein 1; cobalamin synthetase W domain-containing protein 1; dopamine responsive protein; zinc-regulated GTPase metalloprotein activator 1", "tax_id": 10090, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205)", "pathway": " (mmu:226043)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;28135057;28528544;31862704;34428180;35584702", "class_list": "", "function": "Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584702). Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702). Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (PubMed:35584702). After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (PubMed:35584702). GTP/GDP exchange is required for release of active METAP1 (PubMed:35584702)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSA8;Q8K399", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0140827 zinc chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001822 kidney development;GO:0051604 protein maturation;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VEH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI21-1", "uniprot_id": [ { "id": "CLC2F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI21", "type": "external" } ], "mass": 22205.0, "length": 196, "protein_name": "C-type lectin domain family 2 member F", "gene_name": "Clec2f", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clec2f; Clrc", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 2 member F; C-type lectin-related protein C; Clr-c", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11398965", "class_list": "glycogene", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VI21-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920A1-1", "uniprot_id": [ { "id": "CLTR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920A1", "type": "external" } ], "mass": 35213.0, "length": 309, "protein_name": "Cysteinyl leukotriene receptor 2", "gene_name": "Cysltr2", "organism": "Mouse", "refseq_name": "cysteinyl leukotriene receptor 2", "refseq_ac": [ { "id": "NP_001155884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155884", "type": "external" } ], "gene_names_uniprotkb": "Cysltr2; Cyslt2", "gene_names_refseq": "2300001H05Rik; CYSLT2R; Cltr2; Cyslt2; Cysltr2", "protein_names_uniprotkb": "Cysteinyl leukotriene receptor 2; CysLTR2", "protein_names_refseq": "cysteinyl leukotriene receptor 2", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:70086); (R-MMU-391906); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11591709;16756959", "class_list": "", "function": "Findings show that CysLT1 receptor attenuates while CysLT2 receptor facilitates oxygen glucose deprivation -induced PC12 cell death, [RefSeq, PubMed]; Receptor for cysteinyl leukotrienes. The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RT90", "ec_number_list": [], "go_molecular_function": "GO:0001631 cysteinyl leukotriene receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045766 positive regulation of angiogenesis;GO:0060253 negative regulation of glial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920A1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921W0-1", "uniprot_id": [ { "id": "CHM1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921W0", "type": "external" } ], "mass": 21608.0, "length": 196, "protein_name": "Charged multivesicular body protein 1a", "gene_name": "Chmp1a", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 1a", "refseq_ac": [ { "id": "NP_663581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663581", "type": "external" } ], "gene_names_uniprotkb": "Chmp1a; Chmp1; Pcoln3", "gene_names_refseq": "2900018H07Rik; Chmp1a; Pcoln3", "protein_names_uniprotkb": "Charged multivesicular body protein 1a; CHMP1a; Chromatin-modifying protein 1a", "protein_names_refseq": "charged multivesicular body protein 1a; chromatin modifying protein 1A; chromatin-modifying protein 1a; procollagen (type III) N-endopeptidase", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 8 (Disease Ontology:DOID:0060277)", "pathway": " (mmu:234852)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11559747;30044992;31894018;34426578;34428180", "class_list": "", "function": "A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Findings show CHMP1A loss impairs secretion of SHH on ART-EVs, providing molecular mechanistic insights into the role of ESCRT proteins and EVs in the brain., [RefSeq, PubMed]; MiR-17 regulates the proliferation and differentiation of retinal progenitor cells by targeting CHMP1A., [RefSeq, PubMed]; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TW57", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0000794 condensed nuclear chromosome;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921W0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LI2-1", "uniprot_id": [ { "id": "CLCC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LI2", "type": "external" } ], "mass": 60621.0, "length": 539, "protein_name": "Chloride channel CLIC-like protein 1", "gene_name": "Clcc1", "organism": "Mouse", "refseq_name": "chloride channel CLIC-like protein 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001171242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171242", "type": "external" } ], "gene_names_uniprotkb": "Clcc1", "gene_names_refseq": "Clcc1; ERAC1; Mclc", "protein_names_uniprotkb": "Chloride channel CLIC-like protein 1; ER anion channel 1; ERAC1", "protein_names_refseq": "ER anion channel 1; Mid-1-related chloride channel 1; chloride channel CLIC-like protein 1 isoform 2 precursor; chloride channel CLIC-like protein 1", "tax_id": 10090, "disease": "retinitis pigmentosa 32 (Disease Ontology:DOID:0110355)", "pathway": " (mmu:229725)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;19144319;21183079;21750661;25698737;30157172;31219806;37142673", "class_list": "", "function": "Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (PubMed:37142673). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (PubMed:25698737, PubMed:30157172, PubMed:37142673)., [UniProtKB, PubMed, PubMed, PubMed]; Clcc1+/- KO mice showed decreased electroretinogram and photoreceptor number. Intracellular chloride transport by CLCC1 is a critical process in maintaining retinal integrity, and CLCC1 is crucial for survival and function of retinal cells. Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies., [RefSeq, PubMed]; This study demonistrated that Loss of Clcc1 results in ER stress, misfolded protein accumulation, and neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEK9", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006821 chloride transport;GO:0032469 endoplasmic reticulum calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LI2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LU0-1", "uniprot_id": [ { "id": "CH1B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LU0", "type": "external" } ], "mass": 22124.0, "length": 199, "protein_name": "Charged multivesicular body protein 1B1", "gene_name": "Chmp1b1", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 1B1", "refseq_ac": [ { "id": "NP_077152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077152", "type": "external" } ], "gene_names_uniprotkb": "Chmp1b1; Chmp1b", "gene_names_refseq": "2810405I11Rik; Chmp1b1; Chmp1b", "protein_names_uniprotkb": "Charged multivesicular body protein 1B1; CHMP1b-1; Chromatin-modifying protein 1b-1", "protein_names_refseq": "charged multivesicular body protein 1B1; charged multivesicular body protein 1b-1; chromatin modifying protein 1B; chromatin-modifying protein 1b-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67064)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26495903;34428180", "class_list": "", "function": "Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB77;Q9CXR5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0090541 MIT domain binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99LU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR34-1", "uniprot_id": [ { "id": "CE052_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR34", "type": "external" } ], "mass": 19722.0, "length": 168, "protein_name": "Uncharacterized protein C5orf52 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C5orf52 homolog", "refseq_ac": [ { "id": "NP_080426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080426", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4921536K21Rik", "protein_names_uniprotkb": "Uncharacterized protein C5orf52 homolog", "protein_names_refseq": "uncharacterized protein C5orf52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSB3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CR34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ92-1", "uniprot_id": [ { "id": "CENPP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ92", "type": "external" } ], "mass": 33288.0, "length": 286, "protein_name": "Centromere protein P", "gene_name": "Cenpp", "organism": "Mouse", "refseq_name": "centromere protein P", "refseq_ac": [ { "id": "NP_079771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079771", "type": "external" } ], "gene_names_uniprotkb": "Cenpp", "gene_names_refseq": "1700022C02Rik; 4921518G09Rik; Cenpp", "protein_names_uniprotkb": "Centromere protein P; CENP-P", "protein_names_refseq": "CENP-P; centromere protein P", "tax_id": 10090, "disease": "", "pathway": " (mmu:66336); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KM2;Q8C647;Q9CVW9;Q9D5U7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007059 chromosome segregation;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZ92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZP7-1", "uniprot_id": [ { "id": "CD37L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZP7", "type": "external" } ], "mass": 38439.0, "length": 335, "protein_name": "Hsp90 co-chaperone Cdc37-like 1", "gene_name": "Cdc37l1", "organism": "Mouse", "refseq_name": "hsp90 co-chaperone Cdc37-like 1 isoform 2", "refseq_ac": [ { "id": "NP_001289309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289309", "type": "external" } ], "gene_names_uniprotkb": "Cdc37l1", "gene_names_refseq": "2700033A15Rik; Cdc37l1; Cdc37l; Harc", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37-like 1", "protein_names_refseq": "Hsp90-associating relative of Cdc37; cell division cycle 37 homolog-like 1; hsp90 co-chaperone Cdc37-like 1 isoform 2; hsp90 co-chaperone Cdc37-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67072); (R-MMU-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25153642;28135057;28528544;30084848;40885482", "class_list": "", "function": "Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNC7;Q8BP15;Q8C892;Q8C8X2;Q9CU15", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZP7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZR4-1", "uniprot_id": [ { "id": "CKLF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZR4", "type": "external" } ], "mass": 19527.0, "length": 173, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 8", "gene_name": "Cmtm8", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 8", "refseq_ac": [ { "id": "NP_081570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081570", "type": "external" } ], "gene_names_uniprotkb": "Cmtm8; Cklfsf8", "gene_names_refseq": "2700018N07Rik; Cklfsf8; Cmtm8", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 8; Chemokine-like factor superfamily member 8", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 8; chemokine-like factor super family 8; chemokine-like factor superfamily member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:70031)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CZR4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4C9-1", "uniprot_id": [ { "id": "CLVS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4C9", "type": "external" } ], "mass": 40613.0, "length": 354, "protein_name": "Clavesin-1", "gene_name": "Clvs1", "organism": "Mouse", "refseq_name": "clavesin-1", "refseq_ac": [ { "id": "NP_083216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083216", "type": "external" } ], "gene_names_uniprotkb": "Clvs1; Rlbp1l1", "gene_names_refseq": "4933402J24Rik; Clvl1; Clvs1; Rlbp1l1", "protein_names_uniprotkb": "Clavesin-1; Retinaldehyde-binding protein 1-like 1", "protein_names_refseq": "clavesin-1; retinaldehyde-binding protein 1-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74438); (R-MMU-432720)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20485683", "class_list": "", "function": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWV3;Q497H3;Q8BJE8;Q8BXX0", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5Y0-1", "uniprot_id": [ { "id": "SMIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5Y0", "type": "external" } ], "mass": 67661.0, "length": 588, "protein_name": "Sperm-associated microtubule inner protein 4", "gene_name": "Spmip4", "organism": "Mouse", "refseq_name": "sperm-associated microtubule inner protein 4", "refseq_ac": [ { "id": "NP_081840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081840", "type": "external" } ], "gene_names_uniprotkb": "Spmip4; C7orf31", "gene_names_refseq": "4921507P07Rik; Spmip4; TISP74", "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 4; Protein TISP74", "protein_names_refseq": "sperm associated microtubule inner protein 4; sperm-associated microtubule inner protein 4; uncharacterized protein C7orf31 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70821)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32588039", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4U1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7U6-1", "uniprot_id": [ { "id": "CLD22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7U6", "type": "external" } ], "mass": 24310.0, "length": 220, "protein_name": "Claudin-22", "gene_name": "Cldn22", "organism": "Mouse", "refseq_name": "claudin-22", "refseq_ac": [ { "id": "NP_083659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083659", "type": "external" } ], "gene_names_uniprotkb": "Cldn22", "gene_names_refseq": "2210404A22Rik; 5330431C14Rik; 9530051B05Rik; Cldn22", "protein_names_uniprotkb": "Claudin-22", "protein_names_refseq": "claudin-22", "tax_id": 10090, "disease": "", "pathway": " (mmu:75677)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the Wwc2 gene (GeneID: 52357) on the opposite strand. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7U6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D869-1", "uniprot_id": [ { "id": "CHP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D869", "type": "external" } ], "mass": 22567.0, "length": 196, "protein_name": "Calcineurin B homologous protein 2", "gene_name": "Chp2", "organism": "Mouse", "refseq_name": "calcineurin B homologous protein 2", "refseq_ac": [ { "id": "NP_081639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081639", "type": "external" } ], "gene_names_uniprotkb": "Chp2; Hca520", "gene_names_refseq": "2010110P09Rik; Cbhp2; Chp2", "protein_names_uniprotkb": "Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520 homolog", "protein_names_refseq": "calcineurin B homologous protein 2; hepatocellular carcinoma-associated antigen 520 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70261)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEK2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0008284 positive regulation of cell population proliferation;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D869-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9B0-1", "uniprot_id": [ { "id": "CCD70_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9B0", "type": "external" } ], "mass": 27598.0, "length": 223, "protein_name": "Coiled-coil domain-containing protein 70", "gene_name": "Ccdc70", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 70", "refseq_ac": [ { "id": "NP_080735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080735", "type": "external" } ], "gene_names_uniprotkb": "Ccdc70", "gene_names_refseq": "1700112P19Rik; Ccdc70", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 70", "protein_names_refseq": "coiled-coil domain-containing protein 70", "tax_id": 10090, "disease": "", "pathway": " (mmu:67929)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9H6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9B0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQC0-1", "uniprot_id": [ { "id": "CHST1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQC0", "type": "external" } ], "mass": 46904.0, "length": 411, "protein_name": "Carbohydrate sulfotransferase 1", "gene_name": "Chst1", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 1", "refseq_ac": [ { "id": "NP_076339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076339", "type": "external" } ], "gene_names_uniprotkb": "Chst1; Gst1", "gene_names_refseq": "2610008E20Rik; C6ST; Chst1; GST-1; Gst1; KS6ST; KSGAL6ST; KSST", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 1; 2.8.2.21; GST-1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; KS6ST; KSGal6ST; KSST; Keratan sulfate Gal-6 sulfotransferase", "protein_names_refseq": "N-acetylglucosamine-6-O-sulfotransferase 1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; carbohydrate sulfotransferase 1; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; keratan sulfate Gal-6 sulfotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:76969); (R-MMU-2022854)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11181564;23254996;24152993;29659839", "class_list": "glycogene", "function": "CHST1 does not contribute to the synthesis of glycan ligands for Siglec-F in the airways, although its absence results in exaggerated accumulation of airway macrophages and lymphocytes., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (PubMed:24152993). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (By similarity) (PubMed:23254996). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0K5", "ec_number_list": [ { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146 sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006954 inflammatory response;GO:0006790 sulfur compound metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQC0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL21-1", "uniprot_id": [ { "id": "CCR10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL21", "type": "external" } ], "mass": 38900.0, "length": 362, "protein_name": "C-C chemokine receptor type 10", "gene_name": "Ccr10", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 10", "refseq_ac": [ { "id": "NP_031747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031747", "type": "external" } ], "gene_names_uniprotkb": "Ccr10; Cmkbr9; Gpr2", "gene_names_refseq": "C-C CKR-10; CC-CKR-10; CCR-10; Ccr10; Cmkbr9; Gpr2", "protein_names_uniprotkb": "C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR-10; Chemokine C-C receptor 9; G protein-coupled receptor 2", "protein_names_refseq": "C-C chemokine receptor type 10; G protein-coupled receptor 2; chemokine (C-C motif) receptor 10; chemokine C-C receptor 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:12777); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10725696;10781587;34428180;35144761;37222480", "class_list": "", "function": "Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model., [RefSeq, PubMed]; Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa., [RefSeq, PubMed]; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542A4;Q9JIP1;Q9JL20", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JL21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL99-1", "uniprot_id": [ { "id": "CLC1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL99", "type": "external" } ], "mass": 26239.0, "length": 229, "protein_name": "C-type lectin domain family 1 member B", "gene_name": "Clec1b", "organism": "Mouse", "refseq_name": "C-type lectin domain family 1 member B isoform 2", "refseq_ac": [ { "id": "NP_001191168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191168", "type": "external" } ], "gene_names_uniprotkb": "Clec1b; Clec2", "gene_names_refseq": "1810061I13Rik; Clec-2; Clec1b; Clec2", "protein_names_uniprotkb": "C-type lectin domain family 1 member B; C-type lectin-like receptor 2; CLEC-2", "protein_names_refseq": "C-type lectin domain family 1 member B isoform 2; C-type lectin-like receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56760); (R-MMU-114604); (R-MMU-9707616)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10671229;16174766;17616532;18361921;20525685;22740230;25908104;35817083;38531221;38561690", "class_list": "glycogene", "function": "C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2., [UniProtKB, UniProtKB]; CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear., [RefSeq, PubMed]; CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, [RefSeq, PubMed]; Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis., [RefSeq, PubMed]; The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Two novel splicing variants of mCLEC-2 derived from omission of exon 2 and 2/4, respectively, were indentified in mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0T1G2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JL99-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000100010001.111.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R007-3", "uniprot_id": [ { "id": "CLC5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R007", "type": "external" } ], "mass": 21696.0, "length": 190, "protein_name": "C-type lectin domain family 5 member A", "gene_name": "Clec5a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 5 member A isoform 1", "refseq_ac": [ { "id": "NP_001033693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033693", "type": "external" } ], "gene_names_uniprotkb": "Clec5a; Clecsf5; Mdl1", "gene_names_refseq": "Clec5a; Clecsf5; Ly100; MDL-1; Mdl1", "protein_names_uniprotkb": "C-type lectin domain family 5 member A; C-type lectin superfamily member 5; MDL-1; Myeloid DAP12-associating lectin 1", "protein_names_refseq": "C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5 member A isoform 1; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; type II transmembrane protein MDL-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23845); (R-MMU-2172127); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10449773;19074552;19251634;20212065;20637688;34428180;36803804;39097839;39443966", "class_list": "glycogene", "function": "CLEC5A mediates Zika virus-induced testicular damage. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a positive regulator of osteoclastogenesis (PubMed:19251634). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (PubMed:20212065)., [UniProtKB, PubMed, PubMed, PubMed]; MDL-1 plays an important role in immune defense as a result of an innate immunity, which involves neutrophils and macrophages, [RefSeq, PubMed]; The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Abeta clearance in Alzheimer's disease mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXC9;Q3UV97;Q8BL24", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0002076 osteoblast development;GO:0033033 negative regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R007-3", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0M0-1", "uniprot_id": [ { "id": "CELR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0M0", "type": "external" } ], "mass": 316986.0, "length": 2919, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 2", "gene_name": "Celsr2", "organism": "Mouse", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_059088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059088", "type": "external" } ], "gene_names_uniprotkb": "Celsr2", "gene_names_refseq": "Adgrc2; Celsr2; EGFL2; Flamingo1; flamingo; mKIAA0279; mfmi1", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 2; Flamingo homolog", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 2 isoform 1 precursor; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); flamingo homolog", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:53883)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10490098;10790539;11850187;21750661;25428506;30899004;33300544;37186402;40885482", "class_list": "", "function": "Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair., [RefSeq, PubMed]; Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2AEE7;Q99K26;Q9Z2R4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0097475 motor neuron migration;GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0006355 regulation of DNA-templated transcription;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9R0M0-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUB6-1", "uniprot_id": [ { "id": "CLCKB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUB6", "type": "external" } ], "mass": 75009.0, "length": 687, "protein_name": "Chloride channel protein ClC-Kb", "gene_name": "Clcnkb", "organism": "Mouse", "refseq_name": "chloride channel protein ClC-Kb", "refseq_ac": [ { "id": "NP_062675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062675", "type": "external" } ], "gene_names_uniprotkb": "Clcnkb; Clckb; Clcnk1l", "gene_names_refseq": "CLCKB; Clc-Ka; Clck2; Clcnk1l; Clcnk2; Clcnkb", "protein_names_uniprotkb": "Chloride channel protein ClC-Kb; Chloride channel Kb; ClC-K2", "protein_names_refseq": "chloride channel K1-like; chloride channel Kb; chloride channel protein ClC-Kb; clC-K2; putative basolateral cTAL chloride channel ClC-Ka; putative basolateral mTAL chloride channel ClC-Ka", "tax_id": 10090, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (mmu:56365); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11014860;11734858;21750661;27335120;33524393;34203471;34499620;35349181;35820727", "class_list": "", "function": "Angiotensin II increases activity of the ClC-K2 Cl(-) channel in collecting duct intercalated cells by stimulating production of reactive oxygen species., [RefSeq, PubMed]; Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (By similarity). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (By similarity). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (PubMed:27335120, PubMed:34499620, PubMed:35349181). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKA (geneID:1187). [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADB6;Q8VCF8", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:0070293 renal absorption;GO:0051453 regulation of intracellular pH;GO:0030321 transepithelial chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUB6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUL8-1", "uniprot_id": [ { "id": "CITE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUL8", "type": "external" } ], "mass": 18398.0, "length": 182, "protein_name": "Cbp/p300-interacting transactivator 4", "gene_name": "Cited4", "organism": "Mouse", "refseq_name": "cbp/p300-interacting transactivator 4", "refseq_ac": [ { "id": "NP_062509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062509", "type": "external" } ], "gene_names_uniprotkb": "Cited4; Mrg2", "gene_names_refseq": "Cited4; MRG-2; Mrg2", "protein_names_uniprotkb": "Cbp/p300-interacting transactivator 4; MRG-2; MSG1-related protein 2", "protein_names_refseq": "cbp/p300-interacting transactivator 4; msg1-related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56222); (R-MMU-8866907)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11581164;12504852;32418505;35787681", "class_list": "", "function": "Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells., [UniProtKB, PubMed, PubMed]; CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress., [RefSeq, PubMed]; Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity. Erratum:[Commun Biol. 2022 Jul 13;5(1):696. doi: 10.1038/s42003-022-03671-8. PMID: 35831490] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66JX0;Q8R176;Q9CZV4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0S4-1", "uniprot_id": [ { "id": "CLD13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0S4", "type": "external" } ], "mass": 23504.0, "length": 211, "protein_name": "Claudin-13", "gene_name": "Cldn13", "organism": "Mouse", "refseq_name": "claudin-13", "refseq_ac": [ { "id": "NP_065250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065250", "type": "external" } ], "gene_names_uniprotkb": "Cldn13", "gene_names_refseq": "2500004B14Rik; Cldn13", "protein_names_uniprotkb": "Claudin-13", "protein_names_refseq": "claudin-13", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (mmu:57255)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16774906;24825397", "class_list": "", "function": "CLDN13 is a constituent of Sertoli cell tight junctions. CLDN13 is expressed throughout the seminiferous cycle and is localized to bicellular tight junctions., [RefSeq, PubMed]; Developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a developmentally expressed renal tight junction protein. This gene is expressed in the cecum, colon, liver and kidney of mice, but is not identified in rat tissues. Humans and chimpanzees lack this gene. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0070160 tight junction", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0061436 establishment of skin barrier;GO:0090303 positive regulation of wound healing;GO:0022604 regulation of cell morphogenesis;GO:0070293 renal absorption", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z0S4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0S7-1", "uniprot_id": [ { "id": "CLD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0S7", "type": "external" } ], "mass": 22897.0, "length": 217, "protein_name": "Claudin-9", "gene_name": "Cldn9", "organism": "Mouse", "refseq_name": "claudin-9", "refseq_ac": [ { "id": "NP_064689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064689", "type": "external" } ], "gene_names_uniprotkb": "Cldn9", "gene_names_refseq": "Cldn9; nmf329", "protein_names_uniprotkb": "Claudin-9", "protein_names_refseq": "claudin-9", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 116 (Disease Ontology:DOID:0112162)", "pathway": " (mmu:56863)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14698084;16774906;34737342", "class_list": "", "function": "Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Publication Status: Online-Only, [RefSeq, PubMed]; Claudin-9 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area., [RefSeq, PubMed]; Developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is developmentally regulated; it is expressed in neonate kidney, but disappers by adulthood. It is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEA4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0001618 virus receptor activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0070830 bicellular tight junction assembly;GO:0045216 cell-cell junction organization;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0120193 tight junction organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z0S7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K158-1", "uniprot_id": [ { "id": "CNPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K158", "type": "external" } ], "mass": 44915.0, "length": 407, "protein_name": "Protein CNPPD1", "gene_name": "Cnppd1", "organism": "Mouse", "refseq_name": "protein CNPPD1", "refseq_ac": [ { "id": "NP_081253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081253", "type": "external" } ], "gene_names_uniprotkb": "Cnppd1", "gene_names_refseq": "1810031K17Rik; Cnppd1", "protein_names_uniprotkb": "Protein CNPPD1", "protein_names_refseq": "protein CNPPD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69171)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;25605945;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE87", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K158-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7F7-1", "uniprot_id": [ { "id": "CHM4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7F7", "type": "external" } ], "mass": 26280.0, "length": 232, "protein_name": "Charged multivesicular body protein 4c", "gene_name": "Chmp4c", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 4c", "refseq_ac": [ { "id": "NP_079795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079795", "type": "external" } ], "gene_names_uniprotkb": "Chmp4c", "gene_names_refseq": "2010012P02Rik; 2210015K02Rik; 2310010I16Rik; Chmp4c; Shax3; Snf7-3", "protein_names_uniprotkb": "Charged multivesicular body protein 4c; CHMP4c; Chromatin-modifying protein 4c", "protein_names_refseq": "Snf7 homologue associated with Alix 3; charged multivesicular body protein 4c; chromatin modifying protein 4C; chromatin-modifying protein 4c", "tax_id": 10090, "disease": "", "pathway": " (mmu:66371); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "21750661;30084848;34428180;37846580;39369944", "class_list": "", "function": "Crucial role of Snf7-3 in synaptic function and cognitive behavior revealed by conventional and conditional knockout mouse models., [RefSeq, PubMed]; ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by Targeting the Endo-Lysosomal Degradation of EGFR., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149R2;Q3TVD7;Q9CWH8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7F7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1L0-1", "uniprot_id": [ { "id": "CEA15_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1L0", "type": "external" } ], "mass": 26408.0, "length": 234, "protein_name": "Cell adhesion molecule CEACAM15", "gene_name": "Ceacam15", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM15 precursor", "refseq_ac": [ { "id": "NP_780524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780524", "type": "external" } ], "gene_names_uniprotkb": "Ceacam15", "gene_names_refseq": "C430002N04Rik; Ceacam15", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM15; CEA cell adhesion molecule 15; Carcinoembryonic antigen-related cell adhesion molecule 15", "protein_names_refseq": "CEA-related cell adhesion molecule 15; carcinoembryonic antigen-related cell adhesion molecule 15; cell adhesion molecule CEACAM15 precursor; cell adhesion molecule CEACAM15", "tax_id": 10090, "disease": "", "pathway": " (mmu:101434)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16139472", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0JLX4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1L0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXL3-1", "uniprot_id": [ { "id": "CHOLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXL3", "type": "external" } ], "mass": 22168.0, "length": 195, "protein_name": "Cholesin", "gene_name": "Chlsn", "organism": "Mouse", "refseq_name": "cholesin isoform 1", "refseq_ac": [ { "id": "NP_082745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082745", "type": "external" } ], "gene_names_uniprotkb": "Chlsn; 3110082I17Rik", "gene_names_refseq": "3110082I17Rik; C7orf50; Chlsn", "protein_names_uniprotkb": "Cholesin; Protein C7orf50 homolog", "protein_names_refseq": "cholesin isoform 1; uncharacterized protein C7orf50 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73212)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19144319;21183079;21750661;38503280", "class_list": "", "function": "A gut-derived hormone regulates cholesterol metabolism., [RefSeq, PubMed]; Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E8F7;Q6PDQ0", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045540 regulation of cholesterol biosynthetic process;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CXL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ10-1", "uniprot_id": [ { "id": "CHMP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ10", "type": "external" } ], "mass": 25219.0, "length": 224, "protein_name": "Charged multivesicular body protein 3", "gene_name": "Chmp3", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 3 isoform 1", "refseq_ac": [ { "id": "NP_080059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080059", "type": "external" } ], "gene_names_uniprotkb": "Chmp3; Vps24", "gene_names_refseq": "25.1; 4921505F14Rik; 9130011K15Rik; CGI-49; Chmp3; D6Ertd286e; NEDF; Vps24", "protein_names_uniprotkb": "Charged multivesicular body protein 3; Chromatin-modifying protein 3; Vacuolar protein sorting-associated protein 24", "protein_names_refseq": "charged multivesicular body protein 3 isoform 1; chromatin-modifying protein 3; neuroendocrine differentiation factor; vacuolar protein sorting-associated protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:66700); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "15345747;17331679;21750661;26495903;30084848;37828378", "class_list": "", "function": "Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2Z2;Q9D7A5", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0031210 phosphatidylcholine binding;GO:1990381 ubiquitin-specific protease binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005643 nuclear pore;GO:0005769 early endosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810N5-1", "uniprot_id": [ { "id": "CL060_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810N5", "type": "external" } ], "mass": 28062.0, "length": 247, "protein_name": "Uncharacterized protein C12orf60 homolog", "gene_name": "BC049715", "organism": "Mouse", "refseq_name": "uncharacterized protein C12orf60 homolog", "refseq_ac": [ { "id": "NP_848891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848891", "type": "external" } ], "gene_names_uniprotkb": "BC049715", "gene_names_refseq": "BC049715", "protein_names_uniprotkb": "Uncharacterized protein C12orf60 homolog", "protein_names_refseq": "uncharacterized protein C12orf60 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:320135)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8R6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70194-1", "uniprot_id": [ { "id": "CLC4F_MOUSE", "url": "https://www.uniprot.org/uniprot/P70194", "type": "external" } ], "mass": 61269.0, "length": 548, "protein_name": "C-type lectin domain family 4 member F", "gene_name": "Clec4f", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member F", "refseq_ac": [ { "id": "NP_058031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058031", "type": "external" } ], "gene_names_uniprotkb": "Clec4f; Clecsf13; Kclr", "gene_names_refseq": "Clec4f; Clecsf13; KUCR_MOUSE; Kclr", "protein_names_uniprotkb": "C-type lectin domain family 4 member F; C-type lectin 13; C-type lectin superfamily member 13; Kupffer cell receptor", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; C-type lectin 13; C-type lectin domain family 4 member F; C-type lectin superfamily member 13; Kupffer cell c-type lectin receptor; kupffer cell receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:51811)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23762286;30084848;30590594;30779550;31369681", "class_list": "glycogene", "function": "CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB]; The CLEC4f protein is expressed in spleen in non-human primates and the close evolutionary relationship of the CLEC4f protein to langerin (CD207) suggest that it may function in the immune system, possibly as a pathogen receptor., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLZ8", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity;GO:0005534 galactose binding;GO:0051861 glycolipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70194-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIY8-1", "uniprot_id": [ { "id": "NT8F3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIY8", "type": "external" } ], "mass": 25956.0, "length": 226, "protein_name": "N-acetyltransferase family 8 member 3", "gene_name": "Nat8f3", "organism": "Mouse", "refseq_name": "N-acetyltransferase family 8 member 3", "refseq_ac": [ { "id": "NP_001032931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032931", "type": "external" } ], "gene_names_uniprotkb": "Nat8f3; Cml3", "gene_names_refseq": "4833414A14Rik; 4930583K21Rik; Cml3; Nat8f3", "protein_names_uniprotkb": "N-acetyltransferase family 8 member 3; 2.3.1.48; Camello-like protein 3; N-acetyltransferase CML3", "protein_names_refseq": "N-acetyltransferase family 8 member 3; camello-like 3; camello-like protein 3; probable N-acetyltransferase CML3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504710); (mmu:93674)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11397015;21750661;25123547;30084848", "class_list": "", "function": "Has histone acetyltransferase activity in vitro, with specificity for histone H4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQW2;Q91WM7", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0001702 gastrulation with mouth forming second;GO:0003401 axis elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JIY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LJ5-1", "uniprot_id": [ { "id": "CKLF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LJ5", "type": "external" } ], "mass": 20247.0, "length": 184, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 3", "gene_name": "Cmtm3", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 3", "refseq_ac": [ { "id": "NP_077179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077179", "type": "external" } ], "gene_names_uniprotkb": "Cmtm3; Cklfsf3", "gene_names_refseq": "9430096L06Rik; BNAS2; Cklfsf3; Cmtm3", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 3; Chemokine-like factor superfamily member 3", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 3; chemokine-like factor super family 3; chemokine-like factor superfamily member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:68119)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;36284038;37229825;39195242", "class_list": "", "function": "CMTM3 Suppresses Proliferation and Osteogenic Transdifferentiation of C2C12 Myoblasts through p53 Upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling., [RefSeq, PubMed]; In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARgamma)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6B5;Q8BJU1;Q9D165", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0001835 blastocyst hatching;GO:0050861 positive regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99LJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URR0-1", "uniprot_id": [ { "id": "CENPW_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URR0", "type": "external" } ], "mass": 9734.0, "length": 86, "protein_name": "Centromere protein W", "gene_name": "Cenpw", "organism": "Mouse", "refseq_name": "centromere protein W", "refseq_ac": [ { "id": "NP_001103217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103217", "type": "external" } ], "gene_names_uniprotkb": "Cenpw; Cug2", "gene_names_refseq": "2610036L11Rik; Cenpw; Cug2", "protein_names_uniprotkb": "Centromere protein W; CENP-W; Cancer-up-regulated gene 2 protein", "protein_names_refseq": "CENP-W; cancer-up-regulated gene 2 protein; centromere protein W", "tax_id": 10090, "disease": "", "pathway": " (mmu:66311); (R-MMU-606279)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17610844;21750661;25605945;26496357;32446395", "class_list": "", "function": "CENP-W regulates kinetochore-microtubule attachment and meiotic progression of mouse oocytes., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity)., [UniProtKB, PubMed]; We determined that Poc1a, encoding protein of the centriole 1a, is disrupted by the insertion of a processed Cenpw cDNA, which is flanked by target site duplications, suggestive of a LINE-1 retrotransposon-mediated event Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3URR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K182-1", "uniprot_id": [ { "id": "CO8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K182", "type": "external" } ], "mass": 66080.0, "length": 587, "protein_name": "Complement component C8 alpha chain", "gene_name": "C8a", "organism": "Mouse", "refseq_name": "complement component C8 alpha chain isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_666260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666260", "type": "external" } ], "gene_names_uniprotkb": "C8a", "gene_names_refseq": "C8a", "protein_names_uniprotkb": "Complement component C8 alpha chain; Complement component 8 subunit alpha", "protein_names_refseq": "complement component 8 alpha subunit; complement component C8 alpha chain isoform 1 preproprotein; complement component C8 alpha chain", "tax_id": 10090, "disease": "type I complement component 8 deficiency (Disease Ontology:DOID:0060301); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:230558); (R-MMU-166665); (R-MMU-977606)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;26495903;34428180;37507081", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8A, together with C8B and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB]; This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 4, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHJ9;Q8CHK1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity;GO:0001848 complement binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex;GO:0005579 membrane attack complex", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0050778 positive regulation of immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K182-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000011100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V53-1", "uniprot_id": [ { "id": "CHSTE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V53", "type": "external" } ], "mass": 43145.0, "length": 376, "protein_name": "Carbohydrate sulfotransferase 14", "gene_name": "Chst14", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 14", "refseq_ac": [ { "id": "NP_082393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082393", "type": "external" } ], "gene_names_uniprotkb": "Chst14; D4st1", "gene_names_refseq": "2600016L03Rik; Chst14; D4ST-1; D4st1", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 14; 2.8.2.35; D4ST-1; Dermatan 4-sulfotransferase 1", "protein_names_refseq": "carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14; carbohydrate sulfotransferase 14; dermatan 4-sulfotransferase 1", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome musculocontractural type 1 (Disease Ontology:DOID:0080736)", "pathway": " (mmu:72136); (R-MMU-2022923)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16702220;18819920;21750661;25428506;31219806;32601684", "class_list": "glycogene", "function": "Analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST), [RefSeq, PubMed]; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development., [UniProtKB, PubMed]; Systematic investigation of the skin in Chst14-/- mice: A model for skin fragility in musculocontractural Ehlers-Danlos syndrome caused by CHST14 variants (mcEDS-CHST14)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AQV3;Q3TXA1;Q8R304;Q9D0P2", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.35", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80V53-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LL3-1", "uniprot_id": [ { "id": "CHSTC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LL3", "type": "external" } ], "mass": 49398.0, "length": 419, "protein_name": "Carbohydrate sulfotransferase 12", "gene_name": "Chst12", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 12", "refseq_ac": [ { "id": "NP_067503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067503", "type": "external" } ], "gene_names_uniprotkb": "Chst12", "gene_names_refseq": "C4S-2; C4ST2; Chst12", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 12; 2.8.2.5; C4ST-2; C4ST2; Chondroitin 4-O-sulfotransferase 2; Chondroitin 4-sulfotransferase 2", "protein_names_refseq": "carbohydrate sulfotransferase 12; chondroitin 4-O-sulfotransferase 2; chondroitin 4-sulfotransferase 2", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:59031); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21942880", "class_list": "glycogene", "function": "Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity)., [UniProtKB]; Chondroitin 4-O-sulfotransferase-2 efficiently transferred sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 4 of non-reducing terminal GalNAc-linkage residues forming chondroitin sulfate., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCX9;Q9JJS3", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.5", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99LL3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJR6-1", "uniprot_id": [ { "id": "CK016_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJR6", "type": "external" } ], "mass": 44484.0, "length": 402, "protein_name": "Uncharacterized protein C11orf16 homolog", "gene_name": "BC051019; D7h11orf16", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf16 homolog", "refseq_ac": [ { "id": "NP_001035790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035790", "type": "external" } ], "gene_names_uniprotkb": "BC051019; D7h11orf16", "gene_names_refseq": "BC051019; D7H11orf16; ICRFP703B1614Q5.5", "protein_names_uniprotkb": "Uncharacterized protein C11orf16 homolog", "protein_names_refseq": "ICRFP703N2430Q5.5; uncharacterized protein C11orf16 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:57355)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11528127;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XE7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKP8-1", "uniprot_id": [ { "id": "CHRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKP8", "type": "external" } ], "mass": 14127.0, "length": 129, "protein_name": "Chromatin accessibility complex protein 1", "gene_name": "Chrac1", "organism": "Mouse", "refseq_name": "chromatin accessibility complex protein 1", "refseq_ac": [ { "id": "NP_444298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444298", "type": "external" } ], "gene_names_uniprotkb": "Chrac1", "gene_names_refseq": "2410152E03Rik; 2810406L04Rik; Chrac1; YCL1", "protein_names_uniprotkb": "Chromatin accessibility complex protein 1; CHRAC-1; DNA polymerase epsilon subunit p15; NF-YC-like protein; YC-like protein 1; YCL1", "protein_names_refseq": "CHRAC-1; DNA polymerase epsilon subunit p15; NF-YC-like protein; YC-like protein 1; chromatin accessibility complex protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:93696)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11000277;15345747;17242355;19224205;20173027;21183079;21750661;22544926;25428506;25605945;30084848;30779550;34428180;35820727", "class_list": "", "function": "Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VG2", "ec_number_list": [], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0008623 CHRAC", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006275 regulation of DNA replication;GO:0006334 nucleosome assembly;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JKP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35372-1", "uniprot_id": [ { "id": "CNIH1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35372", "type": "external" } ], "mass": 16699.0, "length": 144, "protein_name": "Protein cornichon homolog 1", "gene_name": "Cnih1", "organism": "Mouse", "refseq_name": "protein cornichon homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_034049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034049", "type": "external" } ], "gene_names_uniprotkb": "Cnih1; Cnih", "gene_names_refseq": "0610007J15; CNIH-1; Cnih1; Cnih", "protein_names_uniprotkb": "Protein cornichon homolog 1; CNIH-1; Cornichon family AMPA receptor auxiliary protein 1; Protein cornichon homolog", "protein_names_refseq": "protein cornichon homolog 1 isoform 1; protein cornichon homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12793); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10022955;21750661;25428506", "class_list": "", "function": "Involved in the selective transport and maturation of TGF-alpha family proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZWW6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35372-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM3-1", "uniprot_id": [ { "id": "CLCF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZM3", "type": "external" } ], "mass": 25261.0, "length": 225, "protein_name": "Cardiotrophin-like cytokine factor 1", "gene_name": "Clcf1", "organism": "Mouse", "refseq_name": "cardiotrophin-like cytokine factor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001296967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296967", "type": "external" } ], "gene_names_uniprotkb": "Clcf1; Bsf3; Nnt1", "gene_names_refseq": "BSF-3; Bsf3; CLC; Clcf1; NNT-1", "protein_names_uniprotkb": "Cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; NNT-1; Novel neurotrophin-1", "protein_names_refseq": "B-cell stimulating factor 3; cardiotrophin-like cytokine factor 1 isoform 2 precursor; neurotrophin-1/B-cell stimulating factor-3; novel neurotrophin-1", "tax_id": 10090, "disease": "cold-induced sweating syndrome 2 (Disease Ontology:DOID:0080330); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:56708); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10500198;12090754;14605001;21750661;34428180;38190531", "class_list": "", "function": "CLC plays a role in astrocyte differentiation via STAT3 activation within the developing brain, [RefSeq, PubMed]; CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis., [RefSeq, PubMed]; Functions as a cytokine, either alone or by forming a stable complex with soluble CRLF1 or CNTFR. Binds to CNTFR complex (CNTFR, IL6ST/gp130, LIFR) or can signal via trans-signaling using soluble CNTFR subunits. Mechanistically, ligand binding to CNTFR, induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Moreover, CLCF1/CLF heterodimer induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits PIK3 protein kinase followed by AKT protein phosphorylation. Participates in the survival of embryonic motor neurons (By similarity). Also stimulates B-cells (PubMed:10500198)., [UniProtKB, PubMed, UniProtKB]; Neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXK2", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0097058 CRLF-CLCF1 complex;GO:0097059 CNTFR-CLCF1 complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process;GO:0030890 positive regulation of B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIZ0-1", "uniprot_id": [ { "id": "CMLO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIZ0", "type": "external" } ], "mass": 25014.0, "length": 222, "protein_name": "N-acetyltransferase 8F1", "gene_name": "Nat8f1", "organism": "Mouse", "refseq_name": "N-acetyltransferase 8F1", "refseq_ac": [ { "id": "NP_075649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075649", "type": "external" } ], "gene_names_uniprotkb": "Nat8f1; Cml1", "gene_names_refseq": "1110002I11Rik; Cml1; Nat8f1", "protein_names_uniprotkb": "N-acetyltransferase 8F1; 2.3.1.-; Camello-like protein 1; GCN5-related N-acetyltransferase 8, family member 1", "protein_names_refseq": "GCN5-related N-acetyltransferase 8, family member 1; N-acetyltransferase 8F1; camello-like 1; camello-like protein 1; probable N-acetyltransferase CML1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66116)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11397015;21750661;22267734;34428180;37453647", "class_list": "", "function": "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation., [RefSeq, PubMed]; May play a role in regulation of gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XE3;Q9CW77", "ec_number_list": [], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression;GO:0001702 gastrulation with mouth forming second;GO:0018003 peptidyl-lysine N6-acetylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHS4-1", "uniprot_id": [ { "id": "CLPX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHS4", "type": "external" } ], "mass": 69229.0, "length": 634, "protein_name": "ATP-dependent clpX-like chaperone, mitochondrial", "gene_name": "Clpx", "organism": "Mouse", "refseq_name": "ATP-dependent clpX-like chaperone, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_035932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035932", "type": "external" } ], "gene_names_uniprotkb": "Clpx", "gene_names_refseq": "Clpx; E330029I21", "protein_names_uniprotkb": "ATP-dependent clpX-like chaperone, mitochondrial; 3.6.4.10; ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; Caseinolytic mitochondrial matrix peptidase chaperone subunit", "protein_names_refseq": "ATP-dependent CLP protease ATP-binding subunit ClpX-like, mitochondrial; ATP-dependent clpX-like chaperone, mitochondrial isoform 1; ATP-dependent clpX-like chaperone, mitochondrial; caseinolytic peptidase X; caseinolytic protease X", "tax_id": 10090, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270)", "pathway": " (mmu:270166); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10347188;11003706;21750661;22710082;25428506;30084848;37798322;37828378;38397478;38927630", "class_list": "", "function": "ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:10347188). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (By similarity). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation. Publication Status: Online-Only, [RefSeq, PubMed]; ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLZ8;Q9WVD1", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016504 peptidase activator activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0046034 ATP metabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JHS4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VF58-1", "uniprot_id": [ { "id": "COJA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VF58", "type": "external" } ], "mass": 114197.0, "length": 1136, "protein_name": "Collagen alpha-1(XIX) chain", "gene_name": "Col19a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XIX) chain precursor", "refseq_ac": [ { "id": "NP_031759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031759", "type": "external" } ], "gene_names_uniprotkb": "Col19a1", "gene_names_refseq": "Col19a1", "protein_names_uniprotkb": "Collagen alpha-1(XIX) chain; Collagen alpha-1(Y) chain", "protein_names_refseq": "collagen alpha-1(XIX) chain precursor; collagen alpha-1(XIX) chain; collagen alpha-1(Y) chain; procollagen, type XIX, alpha 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12823); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11169848;15302855;20485683;21750661;31665626;34428180;34993640;9202028", "class_list": "", "function": "Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX., [RefSeq, PubMed]; Collagen XIX has a role in esophageal muscle development and function, [RefSeq, PubMed]; Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Erratum:[Cell Rep. 2020 Aug 25;32(8):108113. doi: 10.1016/j.celrep.2020.108113. PMID: 32846137], [RefSeq, PubMed]; May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35053", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:1990318 collagen type XIX trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0007519 skeletal muscle tissue development;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q0VF58-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCW6-1", "uniprot_id": [ { "id": "CNFN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCW6", "type": "external" } ], "mass": 12302.0, "length": 111, "protein_name": "Cornifelin", "gene_name": "Cnfn", "organism": "Mouse", "refseq_name": "cornifelin isoform 2", "refseq_ac": [ { "id": "NP_001074844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074844", "type": "external" } ], "gene_names_uniprotkb": "Cnfn", "gene_names_refseq": "2210418J09Rik; Cnfn", "protein_names_uniprotkb": "Cornifelin", "protein_names_refseq": "cornifelin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72383)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15147942;21750661", "class_list": "", "function": "Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PCW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQI4-1", "uniprot_id": [ { "id": "IFTAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQI4", "type": "external" } ], "mass": 27654.0, "length": 244, "protein_name": "Intraflagellar transport-associated protein", "gene_name": "Iftap", "organism": "Mouse", "refseq_name": "intraflagellar transport-associated protein isoform 1", "refseq_ac": [ { "id": "NP_080868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080868", "type": "external" } ], "gene_names_uniprotkb": "Iftap; B230118H07Rik; Nwc", "gene_names_refseq": "B230118H07Rik; Iftap; NWC", "protein_names_uniprotkb": "Intraflagellar transport-associated protein; Protein HEPIS; Protein NWC", "protein_names_refseq": "intraflagellar transport-associated protein isoform 1; uncharacterized protein C11orf74 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68170)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15971274;18166226;21183079;21243488;21750661;22984564;25198102;26703212;30476139;30521625", "class_list": "", "function": "Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells, [RefSeq, PubMed]; Careful analysis of the Rag2 intergenic region uncovered a second evolutionarily conserved Nwc promoter region from which a previously unknown Nwc transcript can be generated in nonlymphocytes of Nwctmpro1 and normal mice., [RefSeq, PubMed]; Functional inactivation of NWC does not cause any gross developmental, physiological or reproductive abnormalities, and that under physiological conditions NWC may be involved in assembling and functioning of cilia, [RefSeq, PubMed]; Ikaros, a lymphocyte-specific transcription factor, acts as a repressor of NWC promoter--thus identifying a new Ikaros target--but is insufficient for inducing methylation which depends on antisense transcription driven by RAG-2 promoter Publication Status: Online-Only, [RefSeq, PubMed]; NWC is regulated in lymphocytes by RAG1 promoter, in all other cells by RAG2 intragenic promoter, [RefSeq, PubMed]; NWC-devoid spermatogenesis produces functionally impaired sperm. Sperm of knockout males fail to successfully compete with control sperm. NWC knockout sperm had a reduced ability to fertilize cumulus-intact eggs. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex., [UniProtKB, UniProtKB]; These results indicate that accessibility of NWC promoter and RAG promoters to trans-acting factors is regulated by different epigenetic mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVN5;A2AVN6;Q8C2H0;Q8R186", "ec_number_list": [], "go_molecular_function": "GO:0120160 intraciliary transport particle A binding", "go_cellular_component": "GO:0005829 cytosol;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C172-1", "uniprot_id": [ { "id": "CERS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C172", "type": "external" } ], "mass": 44813.0, "length": 384, "protein_name": "Ceramide synthase 6", "gene_name": "Cers6", "organism": "Mouse", "refseq_name": "ceramide synthase 6 isoform 2", "refseq_ac": [ { "id": "NP_766444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766444", "type": "external" } ], "gene_names_uniprotkb": "Cers6; Lass6", "gene_names_refseq": "4732462C07Rik; Cers6; Lass6; T1L", "protein_names_uniprotkb": "Ceramide synthase 6; 2.3.1.-; 2.3.1.24; 2.3.1.291; CerS6; LAG1 longevity assurance homolog 6; Sphingoid base N-palmitoyltransferase CERS6; Sphingosine N-acyltransferase CERS6", "protein_names_refseq": "LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; ceramide synthase 6 isoform 2; sphingoid base N-palmitoyltransferase CERS6", "tax_id": 10090, "disease": "", "pathway": " (mmu:241447); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "15823095;18250455;18541923;21750661;22544924;23760501;25295788;25428506;25428507;26620563;30084848;30655217;30779550;30899004;31150623;33300544;34428180;38016943", "class_list": "glycogene", "function": "CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Publication Status: Online-Only, [RefSeq, PubMed]; Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:15823095, PubMed:18541923, PubMed:23760501, PubMed:31150623). Can use different sphingoid bases as substrates for ceramide synthesis, such as sphinganine in de novo synthesis, and sphing-4E-enine (sphingosine), (4R)-hydroxysphinganine (phytosphingosine) or sphinga-4E,14Z-dienine in salvage pathways (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (PubMed:22544924).Other fatty acyl-CoAs such as long-chain saturated stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA), myristoyl-CoA (tetradecanoyl-CoA; C14:0-CoA), and monounsaturated oleoyl-CoA (9Z-octadecenoyl-CoA; C18:1-CoA) can also act as acyl donors, but with less efficiency than hexadecanoyl-CoA (PubMed:18541923). Acts as a regulator of metabolism and hepatic lipid accumulation (PubMed:25295788, PubMed:30655217, PubMed:31150623). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (PubMed:31150623)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U817;Q8BV12", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.299", "type": "external" }, { "id": "2.3.1.298", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.298", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.291", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.291", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005634 nucleus", "go_biological_process": "GO:0006954 inflammatory response;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:1900143 positive regulation of oligodendrocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8C172-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TP92-1", "uniprot_id": [ { "id": "CNEP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TP92", "type": "external" } ], "mass": 28391.0, "length": 244, "protein_name": "CTD nuclear envelope phosphatase 1", "gene_name": "Ctdnep1", "organism": "Mouse", "refseq_name": "CTD nuclear envelope phosphatase 1", "refseq_ac": [ { "id": "NP_080293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080293", "type": "external" } ], "gene_names_uniprotkb": "Ctdnep1; Dullard", "gene_names_refseq": "2610507E10Rik; Ctdnep1; Dullard", "protein_names_uniprotkb": "CTD nuclear envelope phosphatase 1; 3.1.3.16; Serine/threonine-protein phosphatase dullard", "protein_names_refseq": "CTD nuclear envelope phosphatase 1; serine/threonine-protein phosphatase dullard", "tax_id": 10090, "disease": "", "pathway": " (mmu:67181); (R-MMU-4419969)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12083771;21750661;22134922;23360989;23469192;25155999;29521016;31219806;32105214;34428180;36210013;36765089;38749090", "class_list": "", "function": "Ctdnep1 phosphatase is required for negative regulation of RANKL-induced osteoclast differentiation in RAW264.7 cells., [RefSeq, PubMed]; Dullard deficiency results in hemorrhagic ovarian cysts and infertility., [RefSeq, PubMed]; Dullard is involved in suppression of TGF-beta signaling during endochondral ossification. Erratum:[J Bone Miner Res. 2015 May;30(5):947. doi: 10.1002/jbmr.2479. Yoichi, Ezura [corrected to Ezura, Yoichi]. PMID: 25879424], [RefSeq, PubMed]; Dullard keeps BMP signalling at an appropriate level, which is required for nephron maintenance in the postnatal period., [RefSeq, PubMed]; Dullard may play a role in the fine-tuning of WNT signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage., [RefSeq, PubMed]; Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB]; Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCW4;Q8VEL4", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0034504 protein localization to nucleus;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006998 nuclear envelope organization;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3TP92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35732-1", "uniprot_id": [ { "id": "CFLAR_MOUSE", "url": "https://www.uniprot.org/uniprot/O35732", "type": "external" } ], "mass": 54875.0, "length": 481, "protein_name": "CASP8 and FADD-like apoptosis regulator", "gene_name": "Cflar", "organism": "Mouse", "refseq_name": "CASP8 and FADD-like apoptosis regulator isoform 1", "refseq_ac": [ { "id": "NP_001276633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276633", "type": "external" } ], "gene_names_uniprotkb": "Cflar; Cash", "gene_names_refseq": "2310024N18Rik; A430105C05Rik; CLARP; Cash; Casper; Cflar; FLAME-1; FLAME; Flip; Gm9845; I-FLICE; MRIT; c-Flip", "protein_names_uniprotkb": "CASP8 and FADD-like apoptosis regulator; CASH; CLARP; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; Casper; Cellular FLICE-like inhibitory protein; FADD-like antiapoptotic molecule 1; FLAME-1; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; Usurpin; c-FLIP", "protein_names_refseq": "CASP8 and FADD-like apoptosis regulator isoform 1; FADD-like antiapoptotic molecule 1; MACH-related inducer of toxicity; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; cellular FLICE-like inhibitory protein; inhibitor of FLICE; usurpin", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); myelodysplastic syndrome (Disease Ontology:DOID:0050908); congestive heart failure (Disease Ontology:DOID:6000); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:12633); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-5357905); (R-MMU-69416); (R-MMU-75158)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10602037;10894163;21750661;30084848;31511692;31519887;31599954;34428180;38824526;39063139;9217161;9289491", "class_list": "", "function": "Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; CFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; The Regulatory Impact of CFLAR Methylation Modification on Liver Lipid Metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z0W6;O35707;O35733", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008047 enzyme activator activity;GO:0016504 peptidase activator activity;GO:0044877 protein-containing complex binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031265 CD95 death-inducing signaling complex", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0043403 skeletal muscle tissue regeneration;GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:1901740 negative regulation of myoblast fusion;GO:1903055 positive regulation of extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35732-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54942-1", "uniprot_id": [ { "id": "CLD5_MOUSE", "url": "https://www.uniprot.org/uniprot/O54942", "type": "external" } ], "mass": 23054.0, "length": 218, "protein_name": "Claudin-5", "gene_name": "Cldn5", "organism": "Mouse", "refseq_name": "claudin-5", "refseq_ac": [ { "id": "NP_038833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038833", "type": "external" } ], "gene_names_uniprotkb": "Cldn5; Bec1", "gene_names_refseq": "Cldn5; MBEC1; Tmvcf", "protein_names_uniprotkb": "Claudin-5; Brain endothelial cell clone 1 protein; Lung-specific membrane protein", "protein_names_refseq": "brain endothelial cell clone 1 protein; claudin-5; lung-specific membrane protein; transmembrane protein deleted in VCFS", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:12741)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10601346;30734065;9520948;9892664", "class_list": "", "function": "Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88789", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0120192 tight junction assembly;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88271-1", "uniprot_id": [ { "id": "CFDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88271", "type": "external" } ], "mass": 32921.0, "length": 295, "protein_name": "Heterochromatin-stabilizing protein CFDP1", "gene_name": "Cfdp1", "organism": "Mouse", "refseq_name": "heterochromatin-stabilizing protein CFDP1 isoform 1", "refseq_ac": [ { "id": "NP_035931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035931", "type": "external" } ], "gene_names_uniprotkb": "Cfdp1; Bcnt; Cfdp; Cp27", "gene_names_refseq": "Bcnt; Bucentaur; Cfdp1; Cfdp; cp27", "protein_names_uniprotkb": "Heterochromatin-stabilizing protein CFDP1; 27 kDa craniofacial protein; Bucentaur; Craniofacial development protein 1; Protein Cp27", "protein_names_refseq": "27 kDa craniofacial protein; heterochromatin-stabilizing protein CFDP1 isoform 1; heterochromatin-stabilizing protein CFDP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23837)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10415329;11368901;11831036;11992732;12153613;17242355;21183079;25428506;25605945;32432658;34428180;38630655;9602175", "class_list": "", "function": "CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation. Publication Status: Online-Only, [RefSeq, PubMed]; Includes the region derived from a long interspersed nucleotide Review article, [RefSeq, PubMed]; Overcoming off-targets: assessing Western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex., [RefSeq, PubMed]; Required for the structural stability of pericentromeric heterochromatin (PubMed:38630655). Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites, and is required for incorporation of histone H2AZ1/H2AZ into chromatin (PubMed:38630655). Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats (PubMed:38630655). Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis (PubMed:38630655). Plays a role in craniofacial development (PubMed:11992732, PubMed:38630655). Required to maintain normal cell function in embryonic development (PubMed:12153613)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70565;Q9JMA5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000776 kinetochore;GO:0000812 Swr1 complex;GO:0005604 basement membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007155 cell adhesion;GO:0042127 regulation of cell population proliferation;GO:0008360 regulation of cell shape;GO:2000270 negative regulation of fibroblast apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88271-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01027-1", "uniprot_id": [ { "id": "CO3_MOUSE", "url": "https://www.uniprot.org/uniprot/P01027", "type": "external" } ], "mass": 186484.0, "length": 1663, "protein_name": "Complement C3", "gene_name": "C3", "organism": "Mouse", "refseq_name": "complement C3 preproprotein", "refseq_ac": [ { "id": "NP_033908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033908", "type": "external" } ], "gene_names_uniprotkb": "C3", "gene_names_refseq": "ASP; C3; HSE-MSF; Plp", "protein_names_uniprotkb": "Complement C3; C3adesArg; Complement C3b-alpha' chain; HSE-MSF", "protein_names_refseq": "acylation stimulating protein; complement C3 preproprotein; complement C3; complement component 3d; complement factor 3", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 7 (Disease Ontology:DOID:0110019); age related macular degeneration 9 (Disease Ontology:DOID:0110021); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); dry eye syndrome (Disease Ontology:DOID:10140); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); lepromatous leprosy (Disease Ontology:DOID:10887); sickle cell anemia (Disease Ontology:DOID:10923); membranous glomerulonephritis (Disease Ontology:DOID:10976); pneumocystosis (Disease Ontology:DOID:11339); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); factor VIII deficiency (Disease Ontology:DOID:12134); neurodegenerative disease (Disease Ontology:DOID:1289); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); arteriolosclerosis (Disease Ontology:DOID:5162); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); conjunctivitis (Disease Ontology:DOID:6195); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); complement component 3 deficiency (Disease Ontology:DOID:8354); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12266); (R-MMU-173736); (R-MMU-174577); (R-MMU-198933); (R-MMU-375276); (R-MMU-381426); (R-MMU-418594); (R-MMU-6798695); (R-MMU-8957275); (R-MMU-977606)", "pathway_count": 10, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;12244109;18160458;2065778;21750661;23386199;2578664;26495903;26740625;28011936;30084848;30899053;31044023;32152506;34428180;35820727;35984892;36288343;37453647;37507081;39627609;39927985;6094532;6208565;6356427;6548745;6609661;6961437;6985486;7964485;8364938", "class_list": "", "function": "Acts as a chemoattractant for neutrophils in chronic inflammation., [UniProtKB, UniProtKB]; Adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial triglyceride clearance. Appears to stimulate triglyceride synthesis via activation of the PLC, MAPK and AKT signaling pathways. Acts by binding to its receptor, C5AR2, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C5AR2. In contrast to C3a anaphylatoxin peptide, does not show pro-inflammatory activity., [UniProtKB, UniProtKB]; Mediator of local inflammatory process released following cleavage by C3 convertase. Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1. C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development. Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants., [UniProtKB, UniProtKB]; Non-enzymatic component of C5 convertase. Generated following cleavage by C3 convertase, it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. Complement C3b binds covalently via its reactive thioester, to cell surface carbohydrates or immune aggregates. Together with complement C4b, it then recruits the serine protease complement C2b to form the C5 convertase, which cleaves and activate C5, the next component of the complement pathways. In the alternative complement pathway, recruits the serine protease CFB to form the C5 convertase that cleaves and activates C5., [UniProtKB, UniProtKB]; Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, UniProtKB]; Reduction/deficiency in acylation stimulating protein (ASP) is associated with an antiadipogenic state and ASP may provide a target for controlling fat storage, [RefSeq, PubMed]; This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 60, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61370;Q80XP1", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0008289 lipid binding;GO:0048018 receptor ligand activity;GO:0003823 antigen binding;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0032991 protein-containing complex;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0002430 complement receptor mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P01027-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61924-1", "uniprot_id": [ { "id": "COPZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61924", "type": "external" } ], "mass": 20198.0, "length": 177, "protein_name": "Coatomer subunit zeta-1", "gene_name": "Copz1", "organism": "Mouse", "refseq_name": "coatomer subunit zeta-1 isoform 2", "refseq_ac": [ { "id": "NP_062791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062791", "type": "external" } ], "gene_names_uniprotkb": "Copz1; Copz", "gene_names_refseq": "5930435A22Rik; Copz1; D4Ertd360e", "protein_names_uniprotkb": "Coatomer subunit zeta-1; Zeta-1 COP; Zeta-1-coat protein", "protein_names_refseq": "coatomer subunit zeta-1 isoform 2; coatomer subunit zeta-1; nonclathrin coat protein zeta1-COP; zeta-1 COP; zeta-1-coat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56447); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17360540;21750661", "class_list": "", "function": "Analysis of differential localization of coatomer complex isoforms within the Golgi apparatus, [RefSeq, PubMed]; Component of the coatomer complex, involved in retrograde Golgi-to-ER transport (By similarity). The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y3C3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61924-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00780-1", "uniprot_id": [ { "id": "CO8A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00780", "type": "external" } ], "mass": 73607.0, "length": 744, "protein_name": "Collagen alpha-1(VIII) chain", "gene_name": "Col8a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(VIII) chain precursor", "refseq_ac": [ { "id": "NP_031765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031765", "type": "external" } ], "gene_names_uniprotkb": "Col8a1", "gene_names_refseq": "Col8a-1; Col8a1", "protein_names_uniprotkb": "Collagen alpha-1(VIII) chain", "protein_names_refseq": "collagen alpha-1(VIII) chain precursor; collagen alpha-1(VIII) chain; procollagen type VIII alpha 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:12837); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-216083); (R-MMU-8948216)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "12782141;1499564;15063777;16269661;19401424;20485683", "class_list": "", "function": "Crystal structure of mouse alpha1(VIII)(3) NC1 domain trimer at 1.9 A resolution. Surface of collagen VIII NC1 trimer has three strips of partially exposed aromatic residues, likely involved in supramolecular assemblies., [RefSeq, PubMed]; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis., [UniProtKB, PubMed, PubMed, PubMed]; These data indicate that type VIII collagen plays an important role in glial scar formation during the repair process by astrocytes., [RefSeq, PubMed]; Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JJL9;Q3TWU7;Q8BGL6;Q921S8;Q9D2V4", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0071953 elastic fiber", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0048593 camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00780-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U5Q7-1", "uniprot_id": [ { "id": "CMPK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U5Q7", "type": "external" } ], "mass": 50036.0, "length": 447, "protein_name": "UMP-CMP kinase 2, mitochondrial", "gene_name": "Cmpk2", "organism": "Mouse", "refseq_name": "UMP-CMP kinase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_065582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065582", "type": "external" } ], "gene_names_uniprotkb": "Cmpk2; Tyki", "gene_names_refseq": "1200004E04Rik; Cmpk2; TDKI; Tyki", "protein_names_uniprotkb": "UMP-CMP kinase 2, mitochondrial; 2.7.4.14; 2.7.4.6; Nucleoside-diphosphate kinase; TYKi; Thymidylate kinase LPS-inducible member", "protein_names_refseq": "UMP-CMP kinase 2, mitochondrial precursor; UMP-CMP kinase 2, mitochondrial; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; nucleoside-diphosphate kinase; thymidylate kinase LPS-inducible member; thymidylate kinase homologue", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (mmu:22169)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16996144;30046112;36443312;37092308;38701781;40684658;7751651", "class_list": "", "function": "Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p inhibited pyroptosis to alleviate lung ischemic-reperfusion injury by targeting CMPK2., [RefSeq, PubMed]; Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke., [RefSeq, PubMed]; Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (By similarity). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (By similarity). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (PubMed:36443312). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (PubMed:30046112). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (PubMed:30046112)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCI7;Q5XKG5;Q62316;Q6PFG7;Q9DC34", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004798 dTMP kinase activity;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0006233 dTDP biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3U5Q7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V1H1-1", "uniprot_id": [ { "id": "CKAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V1H1", "type": "external" } ], "mass": 74029.0, "length": 664, "protein_name": "Cytoskeleton-associated protein 2", "gene_name": "Ckap2", "organism": "Mouse", "refseq_name": "cytoskeleton-associated protein 2", "refseq_ac": [ { "id": "NP_001004140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004140", "type": "external" } ], "gene_names_uniprotkb": "Ckap2", "gene_names_refseq": "Ckap2; LB1", "protein_names_uniprotkb": "Cytoskeleton-associated protein 2", "protein_names_refseq": "cytoskeleton-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80986)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15504249;16061649;18299400;21183079;21952136;25428506;27055594;27798236;28706298;31219806;31599954;34418053;34428180;35029146", "class_list": "", "function": "Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy., [RefSeq, PubMed]; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner., [UniProtKB, PubMed, PubMed]; The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that the phosphorylation of Cytoskeleton Associated Protein 2 (CKAP2) at T603 and possibly S608 phosphorylation sites by Cyclin Dependent Kinase 1 (CDK1) during mitosis is essential for maintaining the number of centrosomes. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability., [RefSeq, PubMed]; These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties, [RefSeq, PubMed]; We found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H5W7;Q66LN2;Q8BSF0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0000281 mitotic cytokinesis;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q3V1H1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61419-1", "uniprot_id": [ { "id": "CMAH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61419", "type": "external" } ], "mass": 66936.0, "length": 577, "protein_name": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "gene_name": "Cmah", "organism": "Mouse", "refseq_name": "cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a", "refseq_ac": [ { "id": "NP_001104580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104580", "type": "external" } ], "gene_names_uniprotkb": "Cmah", "gene_names_refseq": "Cmah", "protein_names_uniprotkb": "Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; 1.14.18.2; CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase", "protein_names_refseq": "CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase; cytidine monophosphate-N-acetylneuraminic acid hydroxylase isoform a; cytidine monophosphate-N-acetylneuraminic acid hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:12763)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1587278;21750661;22692205;30084848;34428180;37968438;7608218;8132639;8781965", "class_list": "glycogene", "function": "Cmah deficiency blunts cellular senescence in adipose tissues and improves whole-body glucose metabolism in aged mice., [RefSeq, PubMed]; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMR9;Q8JZM9", "ec_number_list": [ { "id": "1.14.18.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0030338 CMP-N-acetylneuraminate monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0030111 regulation of Wnt signaling pathway;GO:0046381 CMP-N-acetylneuraminate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61419-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62398-1", "uniprot_id": [ { "id": "CNGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62398", "type": "external" } ], "mass": 76193.0, "length": 664, "protein_name": "Cyclic nucleotide-gated channel alpha-2", "gene_name": "Cnga2", "organism": "Mouse", "refseq_name": "cyclic nucleotide-gated olfactory channel isoform X1", "refseq_ac": [ { "id": "XP_006527824", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006527824", "type": "external" } ], "gene_names_uniprotkb": "Cnga2; Cncg2; Cncg4", "gene_names_refseq": "CNG2; Cnca; Cncg4; Cnga2; OCNC1", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2; OCNC1; Olfactory cyclic nucleotide-gated channel subunit 1", "protein_names_refseq": "cyclic nucleotide-gated olfactory channel isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12789); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11764791;30779550;8841933", "class_list": "", "function": "Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XH6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0060170 ciliary membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051899 membrane depolarization;GO:0098655 monoatomic cation transmembrane transport;GO:0006813 potassium ion transport;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62398-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62507-1", "uniprot_id": [ { "id": "COCH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62507", "type": "external" } ], "mass": 59950.0, "length": 552, "protein_name": "Cochlin", "gene_name": "Coch", "organism": "Mouse", "refseq_name": "cochlin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001185764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185764", "type": "external" } ], "gene_names_uniprotkb": "Coch", "gene_names_refseq": "Coch-5B2; Coch; D12H14S564E", "protein_names_uniprotkb": "Cochlin; COCH-5B2", "protein_names_refseq": "coagulation factor C homolog (Limulus polyphemus); cochlin isoform 2 precursor", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 9 (Disease Ontology:DOID:0110593); autosomal recessive nonsyndromic deafness 110 (Disease Ontology:DOID:0111644)", "pathway": " (mmu:12810)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;26495903;28011936;29187734;32152506;34428180;9119401;9441737", "class_list": "", "function": "Plays a role in the control of cell shape and motility in the trabecular meshwork., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAF5;Q9QWK6", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62507-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PD19-1", "uniprot_id": [ { "id": "ARMD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PD19", "type": "external" } ], "mass": 78632.0, "length": 689, "protein_name": "Armadillo-like helical domain-containing protein 3", "gene_name": "Armh3", "organism": "Mouse", "refseq_name": "armadillo-like helical domain-containing protein 3", "refseq_ac": [ { "id": "NP_938038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938038", "type": "external" } ], "gene_names_uniprotkb": "Armh3", "gene_names_refseq": "9130011E15Rik; Armh3", "protein_names_uniprotkb": "Armadillo-like helical domain-containing protein 3", "protein_names_refseq": "UPF0668 protein C10orf76 homolog; armadillo-like helical domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71617)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;25428506;30084848;35820727;36921576", "class_list": "", "function": "ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING., [RefSeq, PubMed]; Involved in GBF1 recruitment, Golgi maintenance and protein secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWB1;Q80V50", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0072376 protein activation cascade;GO:0009615 response to virus;GO:0045184 establishment of protein localization;GO:0006895 Golgi to endosome transport;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PD19-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q473-1", "uniprot_id": [ { "id": "CLA4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Q473", "type": "external" } ], "mass": 101872.0, "length": 924, "protein_name": "Calcium-activated chloride channel regulator 4A", "gene_name": "Clca4a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clca4a; Clca6", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 4A; 3.4.-.-; Calcium-activated chloride channel regulator 6; mClca6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:99663)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15284223;18285349;21750661;30084848;34428180", "class_list": "", "function": "May be involved in mediating calcium-activated chloride conductance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6Q472", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6Q473-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QWF9-1", "uniprot_id": [ { "id": "CK2N1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6QWF9", "type": "external" } ], "mass": 8513.0, "length": 78, "protein_name": "Calcium/calmodulin-dependent protein kinase II inhibitor 1", "gene_name": "Camk2n1", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase II inhibitor 1", "refseq_ac": [ { "id": "NP_079727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079727", "type": "external" } ], "gene_names_uniprotkb": "Camk2n1", "gene_names_refseq": "1810006K23Rik; Camk2n1", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase II inhibitor 1; calcium/calmodulin-dependent protein kinase II inhibitor alpha; mCaMKIINalpha", "protein_names_refseq": "CaMKII inhibitor protein alpha; CaMKIIN-alpha; CaMKIINalpha; calcium/calmodulin-dependent protein kinase II inhibitor 1; calcium/calmodulin-dependent protein kinase II inhibitor alpha; mCaMKIINalpha", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:66259)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16819996;17010311;17350603;20693275;28642476;28890075;31327268;33746041;35998547", "class_list": "", "function": "CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/beta-catenin pathway., [RefSeq, PubMed]; Camk2n1 down-regulation caused dorsal striatum-related cognitive disorders by inhibiting synaptic plasticity., [RefSeq, PubMed]; Camk2n1 was shown to be a 37 kDa protein localized in the post synaptic density (PSD) of mouse brain, [RefSeq, PubMed]; Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation., [RefSeq, PubMed]; Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (PubMed:28642476). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (PubMed:33746041). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The mouse Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) gene encodes a 2.9kb brain-specific transcript whose expression is downregulated in mouse brain during Japanese encephalitis virus and rabies virus infection. GeneRIF: Camk2n1 mRNA expression is down regulated in mouse brain during virus infection, [RefSeq, PubMed]; We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0008427 calcium-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0003084 positive regulation of systemic arterial blood pressure;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050729 positive regulation of inflammatory response;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6QWF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SJQ5-1", "uniprot_id": [ { "id": "CLM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6SJQ5", "type": "external" } ], "mass": 27312.0, "length": 245, "protein_name": "CMRF35-like molecule 3", "gene_name": "Cd300ld3", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 3 precursor", "refseq_ac": [ { "id": "NP_954671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954671", "type": "external" } ], "gene_names_uniprotkb": "Cd300ld3; Cd300lh; Clm3; Lmir7", "gene_names_refseq": "Cd300ld3; Cd300lh; Clm3; Lmir7; clm-3", "protein_names_uniprotkb": "CMRF35-like molecule 3; CD300 antigen-like family member H; CD300 molecule-like family member D3; CLM-3", "protein_names_refseq": "CD300 antigen like family member H; CMRF-35-like molecule 3; CMRF35-like molecule 3 precursor; CMRF35-like molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:382551); (R-MMU-198933)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14662855;20817736;21940676", "class_list": "", "function": "Acts as an activating receptor inducing cytokine production in mast cells. Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of pro-inflammatory cytokines., [UniProtKB, PubMed, PubMed]; Data show that LMIR7/CLM-3 shares similarities with LMIR4/CLM-5, although they are differentially regulated in their distribution, expression, and function., [RefSeq, PubMed]; Transgenic CLM-3 selectively promotes production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in macrophages triggered by toll-like receptor (TLR)9, but not TLR4 or TLR3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:0034165 positive regulation of toll-like receptor 9 signaling pathway;GO:0002757 immune response-activating signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6SJQ5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ11-1", "uniprot_id": [ { "id": "CHSS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ11", "type": "external" } ], "mass": 91383.0, "length": 800, "protein_name": "Chondroitin sulfate synthase 1", "gene_name": "Chsy1", "organism": "Mouse", "refseq_name": "chondroitin sulfate synthase 1", "refseq_ac": [ { "id": "NP_001074632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074632", "type": "external" } ], "gene_names_uniprotkb": "Chsy1; Kiaa0990", "gene_names_refseq": "Chsy1; skt", "protein_names_uniprotkb": "Chondroitin sulfate synthase 1; 2.4.1.175; 2.4.1.226; ChSy-1; Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1", "protein_names_refseq": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1; carbohydrate (chondroitin) synthase 1; chondroitin glucuronyltransferase 1; chondroitin sulfate synthase 1; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1", "tax_id": 10090, "disease": "temtamy preaxial brachydactyly syndrome (Disease Ontology:DOID:0050814)", "pathway": " (mmu:269941); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21069351;22280990;26495903;26740625;31219806;34428180;35390446;36047655;37749638", "class_list": "glycogene;glycosyltransferase", "function": "CHSY1 promotes CD8[+] T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening. Publication Status: Online-Only, [RefSeq, PubMed]; Chsy1 deficiency reduces extracellular matrix productions and aggravates cartilage injury in osteoarthritis., [RefSeq, PubMed]; Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling., [UniProtKB, UniProtKB]; Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis., [RefSeq, PubMed]; The results showed that Chsy1 is an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1., [RefSeq, PubMed]; We showed the spatial and temporal expression of Skt gene in the cloacal plate formation. This gene could be a marker for the cloacal plate during the anorectal development. Skt was considered to be associated with the embryogenesis of ARMs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.175", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.175", "type": "external" }, { "id": "2.4.1.226", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.226", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0051923 sulfation;GO:0031667 response to nutrient levels;GO:0009954 proximal/distal pattern formation;GO:0060349 bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6ZQ11-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78WH7-1", "uniprot_id": [ { "id": "CK2N2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78WH7", "type": "external" } ], "mass": 8628.0, "length": 79, "protein_name": "Calcium/calmodulin-dependent protein kinase II inhibitor 2", "gene_name": "Camk2n2", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase II inhibitor 2", "refseq_ac": [ { "id": "NP_082696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082696", "type": "external" } ], "gene_names_uniprotkb": "Camk2n2", "gene_names_refseq": "2900075A18Rik; Camk2n2", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase II inhibitor 2; CaM-KII inhibitory protein; CaM-KIIN", "protein_names_refseq": "caM-KII inhibitory protein; caM-KIIN; calcium/calmodulin-dependent protein kinase II inhibitor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:73047)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28642476;34428180", "class_list": "", "function": "Potent and specific cellular inhibitor of CaM-kinase II (CAMK2) (By similarity). Traps Ca(2+)/calmodulin on CAMK2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008427 calcium-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78WH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TS74-1", "uniprot_id": [ { "id": "CKP2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TS74", "type": "external" } ], "mass": 82999.0, "length": 745, "protein_name": "Cytoskeleton-associated protein 2-like", "gene_name": "Ckap2l", "organism": "Mouse", "refseq_name": "cytoskeleton-associated protein 2-like", "refseq_ac": [ { "id": "NP_853620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853620", "type": "external" } ], "gene_names_uniprotkb": "Ckap2l", "gene_names_refseq": "2010016H04Rik; 2610318C08Rik; Ckap2l; radmis; rdm", "protein_names_uniprotkb": "Cytoskeleton-associated protein 2-like; Radial fiber and mitotic spindle protein; Radmis", "protein_names_refseq": "cytoskeleton-associated protein 2-like; radial fiber and mitotic spindle protein", "tax_id": 10090, "disease": "Filippi syndrome (Disease Ontology:DOID:0112194)", "pathway": " (mmu:70466)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24260314;25439729;28528544;32782141;36852467", "class_list": "", "function": "Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5A3;Q8K264;U6C6D6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007026 negative regulation of microtubule depolymerization;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TS74-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VP5-1", "uniprot_id": [ { "id": "MTRFR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VP5", "type": "external" } ], "mass": 20787.0, "length": 184, "protein_name": "Mitochondrial translation release factor in rescue", "gene_name": "Mtrfr", "organism": "Mouse", "refseq_name": "mitochondrial translation release factor in rescue isoform a", "refseq_ac": [ { "id": "NP_001128189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128189", "type": "external" } ], "gene_names_uniprotkb": "Mtrfr", "gene_names_refseq": "2810006K23Rik; Mtrfr", "protein_names_uniprotkb": "Mitochondrial translation release factor in rescue", "protein_names_refseq": "Probable peptide chain release factor C12orf65 homolog, mitochondrial; mitochondrial translation release factor in rescue isoform a", "tax_id": 10090, "disease": "hereditary spastic paraplegia 55 (Disease Ontology:DOID:0110807); combined oxidative phosphorylation deficiency 7 (Disease Ontology:DOID:0111487)", "pathway": " (mmu:72650)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22821833", "class_list": "", "function": "Determined the solution structure of the GGQ-containing domain (GGQ domain) of C12orf65 from mouse by NMR spectroscopy., [RefSeq, PubMed]; Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3US94;Q8BYK3;Q9CSJ6", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0043023 ribosomal large subunit binding;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0072344 rescue of stalled ribosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WV3-1", "uniprot_id": [ { "id": "CHST2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WV3", "type": "external" } ], "mass": 57828.0, "length": 530, "protein_name": "Carbohydrate sulfotransferase 2", "gene_name": "Chst2", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 2", "refseq_ac": [ { "id": "NP_061233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061233", "type": "external" } ], "gene_names_uniprotkb": "Chst2; Gst2", "gene_names_refseq": "C130041E03Rik; Chst2; Chts2; GST-2; GlcNAc6ST; Gn6st", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 2; 2.8.2.-; GST-2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GlcNAc6ST-1; Gn6st-1; N-acetylglucosamine 6-O-sulfotransferase 1", "protein_names_refseq": "N-acetylglucosamine 6-O-sulfotransferase 1; N-acetylglucosamine-6-O-sulfotransferase; carbohydrate sulfotransferase 2; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; glcNAc6ST-1; gn6st-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54371); (R-MMU-2022854)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15175329;16227985;25428506;30084848;30779550;34428180;37095090;40885482;9712885;9722682", "class_list": "glycogene", "function": "CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N- and O-linked glycans and within O-linked mucin-type glycans (PubMed:15175329, PubMed:16227985, PubMed:9712885). Selectively transfers the sulfate group onto the terminal GlcNAc of alpha1,3-Man or alpha1,6-Man antenna of complex-type N-glycans depending on glycan composition. Only sulfates terminal GlcNAc of alpha1,3-Man antenna of G0 complex-type N-glycans. Can sulfate keratan-type N-acetyllactosamine (LacNAc) repeats generating epitopes for self versus non-self immune recognition by C-type lectins (By similarity). Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalpha-Ser/Thr and with lower efficiency on extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalpha-Ser/Thr based O-linked glycans on peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs). Shares substrate specificity with CHST4 and both contribute to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance (PubMed:15175329, PubMed:16227985). Has no activity toward alpha-linked GlcNAc moiety exposed at the non-reducing ends or to internally located GlcNAc residues (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QNG2;O88276;Q794G9", "ec_number_list": [ { "id": "2.8.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.17", "type": "external" }, { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" }, { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q80WV3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y39-1", "uniprot_id": [ { "id": "CJ062_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y39", "type": "external" } ], "mass": 34025.0, "length": 304, "protein_name": "Uncharacterized protein C10orf62 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C10orf62 homolog", "refseq_ac": [ { "id": "NP_080028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080028", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933411K16Rik", "protein_names_uniprotkb": "Uncharacterized protein C10orf62 homolog", "protein_names_refseq": "uncharacterized protein C10orf62 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66765)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80Y39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG22-1", "uniprot_id": [ { "id": "CLCA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG22", "type": "external" } ], "mass": 103626.0, "length": 942, "protein_name": "Calcium-activated chloride channel regulator 2", "gene_name": "Clca2", "organism": "Mouse", "refseq_name": "calcium-activated chloride channel regulator 2 isoform 1", "refseq_ac": [ { "id": "NP_848812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848812", "type": "external" } ], "gene_names_uniprotkb": "Clca2; Clca5", "gene_names_refseq": "4732440A06; Clca2; Clca5", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 2; 3.4.-.-; Calcium-activated chloride channel family member 5; mCLCA5", "protein_names_refseq": "calcium-activated chloride channel family member 5; calcium-activated chloride channel regulator 2 isoform 1; calcium-activated chloride channel regulator 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:229933); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15284223;15292178;20012443;25828855;27711075;29743348;34203471;34428180", "class_list": "", "function": "Basal NF-kappaB activity is involved in the Ca(2+)-dependent regulation of mCLCA2 expression in a mouse keratinocyte line, [RefSeq, PubMed]; CLCA2 knockdown promoted keratinocyte apoptosis induced by hyperosmotic stress through impairment of cell-cell adhesion., [RefSeq, PubMed]; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4., [UniProtKB, PubMed, PubMed]; Results establish mCLCA5 as the mouse ortholog of hCLCA2, demonstrate that mCLCA5 is a detachment-sensitive growth inhibitor, and suggest a mechanism whereby these channels may antagonize mammary tumor progression, metastases [CLCA5], [RefSeq, PubMed]; Stat3-mediated regulation of expression of members of the calcium-activated chloride channel regulator (CLCA) family of proteins during involution and mammary carcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The results imply that mCLCA5 may play a role in maturation and keratinization of squamous epithelial cells., [RefSeq, PubMed]; This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZF7", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BG22-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHG9-1", "uniprot_id": [ { "id": "CGBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHG9", "type": "external" } ], "mass": 18761.0, "length": 167, "protein_name": "CGG triplet repeat-binding protein 1", "gene_name": "Cggbp1", "organism": "Mouse", "refseq_name": "CGG triplet repeat-binding protein 1", "refseq_ac": [ { "id": "NP_848762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848762", "type": "external" } ], "gene_names_uniprotkb": "Cggbp1", "gene_names_refseq": "Cggbp1", "protein_names_uniprotkb": "CGG triplet repeat-binding protein 1; 20 kDa CGG-binding protein; CGG-binding protein 1; p20-CGGBP DNA-binding protein", "protein_names_refseq": "20 kDa CGG-binding protein; CGG triplet repeat-binding protein 1; CGG-binding protein 1; p20-CGGBP DNA-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:106143)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14667814;25428506;25605945;27802388;34428180", "class_list": "", "function": "Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter (By similarity)., [UniProtKB]; Cggbp1 mRNAs of 1.2 and 4.5 kb are transcribed at varying ratios in embryonic, fetal tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2K1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRC6-2", "uniprot_id": [ { "id": "CFA91_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRC6", "type": "external" } ], "mass": 91623.0, "length": 783, "protein_name": "Cilia- and flagella-associated protein 91", "gene_name": "Cfap91", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 91", "refseq_ac": [ { "id": "NP_001074494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074494", "type": "external" } ], "gene_names_uniprotkb": "Cfap91; Aat1; Maats1; Spata26", "gene_names_refseq": "4932425I24Rik; Aat1; Cfap91; Maats1; Spata26", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 91; AAT-1; AMY-1-associating protein expressed in testis 1 homolog; CFAP91; MYCBP/AMY-1-associated testis-expressed protein 1; Protein MAATS1", "protein_names_refseq": "AAT-1; AMY-1-associating protein expressed in testis 1 homolog; MYCBP-associated, testis expressed 1; MYCBP/AMY-1-associated testis-expressed protein 1; cilia- and flagella-associated protein 91; protein MAATS1; spermatogenesis associated 26", "tax_id": 10090, "disease": "spermatogenic failure 51 (Disease Ontology:DOID:0112273)", "pathway": " (mmu:320214)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12223483;37352829", "class_list": "", "function": "Involved in sperm flagellum axonemal organization and function (By similarity). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PZ32;E9QND1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BRC6-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BT14-1", "uniprot_id": [ { "id": "CNOT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BT14", "type": "external" } ], "mass": 63474.0, "length": 575, "protein_name": "CCR4-NOT transcription complex subunit 4", "gene_name": "Cnot4", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 4 isoform 3", "refseq_ac": [ { "id": "NP_001157883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157883", "type": "external" } ], "gene_names_uniprotkb": "Cnot4; Not4", "gene_names_refseq": "Cnot4; Not4hp; Not4h; Not4", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 4; 2.3.2.27; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4", "protein_names_refseq": "CCR4-NOT transcription complex subunit 4 isoform 3; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; RING-type E3 ubiquitin transferase CNOT4; negative regulator of transcription 4; potential transcriptional repressor NOT4Hp; transcriptional repressor NOT4Hp", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:53621); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "17525332;19144319;21183079;21750661;22517741;22645316;22872234;23443134;24129315;25428506;30016717;30059200;30084848;30779550;31599954;32782141;32848054;33725478;34026442;34428180;34678516;36852467;40021952;40885482", "class_list": "", "function": "Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCR4;Q9CV74;Q9Z1D0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0045652 regulation of megakaryocyte differentiation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8BT14-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXA5-1", "uniprot_id": [ { "id": "CLP1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXA5", "type": "external" } ], "mass": 62183.0, "length": 539, "protein_name": "Lipid scramblase CLPTM1L", "gene_name": "Clptm1l", "organism": "Mouse", "refseq_name": "lipid scramblase CLPTM1L", "refseq_ac": [ { "id": "NP_666159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666159", "type": "external" } ], "gene_names_uniprotkb": "Clptm1l", "gene_names_refseq": "C130052I12Rik; CRR9p; Clptm1l; Crr9", "protein_names_uniprotkb": "Lipid scramblase CLPTM1L; CLPTM1-like protein; CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1-like protein", "protein_names_refseq": "CLPTM1-like protein; cisplatin resistance related protein CRR9p; cisplatin resistance-related protein 9; cleft lip and palate transmembrane protein 1-like protein; lipid scramblase CLPTM1L", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pharynx squamous cell carcinoma (Disease Ontology:DOID:0050921); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:218335)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;22872234;25605945;30084848;30899004;31219806;31599954;34428180;35820727;36210013", "class_list": "", "function": "Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U176;Q8C053;Q8R0P2", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BXA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXA6-1", "uniprot_id": [ { "id": "CLD17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXA6", "type": "external" } ], "mass": 24653.0, "length": 224, "protein_name": "Claudin-17", "gene_name": "Cldn17", "organism": "Mouse", "refseq_name": "claudin-17", "refseq_ac": [ { "id": "NP_852467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852467", "type": "external" } ], "gene_names_uniprotkb": "Cldn17", "gene_names_refseq": "Cldn17", "protein_names_uniprotkb": "Claudin-17", "protein_names_refseq": "claudin-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:239931)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22402829;35681477", "class_list": "", "function": "Channel-forming tight junction protein with selectivity for anions, including chloride and hydrogencarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability., [UniProtKB, UniProtKB]; Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with the Cldn8 gene on chromosome 16. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0015267 channel activity;GO:0005254 chloride channel activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0034707 chloride channel complex;GO:0070160 tight junction", "go_biological_process": "GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0001822 kidney development;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BXA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE97-1", "uniprot_id": [ { "id": "CO062_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE97", "type": "external" } ], "mass": 19657.0, "length": 175, "protein_name": "Uncharacterized protein C15orf62 homolog, mitochondrial", "gene_name": "Gm14137", "organism": "Mouse", "refseq_name": "uncharacterized protein C15orf62 homolog, mitochondrial", "refseq_ac": [ { "id": "NP_001034312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034312", "type": "external" } ], "gene_names_uniprotkb": "Gm14137", "gene_names_refseq": "Gm14137", "protein_names_uniprotkb": "Uncharacterized protein C15orf62 homolog, mitochondrial", "protein_names_refseq": "uncharacterized protein C15orf62 homolog, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:623781)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CE97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHQ9-1", "uniprot_id": [ { "id": "NT8F2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHQ9", "type": "external" } ], "mass": 26424.0, "length": 238, "protein_name": "N-acetyltransferase family 8 member 2", "gene_name": "Nat8f2", "organism": "Mouse", "refseq_name": "N-acetyltransferase family 8 member 2", "refseq_ac": [ { "id": "NP_444326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444326", "type": "external" } ], "gene_names_uniprotkb": "Nat8f2; Cml2", "gene_names_refseq": "Cml2; Nat8f2", "protein_names_uniprotkb": "N-acetyltransferase family 8 member 2; 2.3.1.-; Camello-like protein 2; N-acetyltransferase-like protein CML2", "protein_names_refseq": "N-acetyltransferase family 8 member 2; N-acetyltransferase-like protein CML2; camello-like 2; camello-like protein 2; probable N-acetyltransferase CML2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93673)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11397015;22267734;23576753;25123547;34428180;37453647", "class_list": "", "function": "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation., [RefSeq, PubMed]; Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7E5;Q9JIY9", "ec_number_list": [], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression;GO:0001702 gastrulation with mouth forming second;GO:0018003 peptidyl-lysine N6-acetylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CHQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ61-1", "uniprot_id": [ { "id": "CKLF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ61", "type": "external" } ], "mass": 22921.0, "length": 208, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 4", "gene_name": "Cmtm4", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 4", "refseq_ac": [ { "id": "NP_705810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705810", "type": "external" } ], "gene_names_uniprotkb": "Cmtm4; Cklfsf4", "gene_names_refseq": "Cklfsf4; Cmtm4; Gm9853", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 4; Chemokine-like factor superfamily member 4", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 4; chemokine-like factor super family 4; chemokine-like factor superfamily member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:97487)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30867229;34428180;36271145;38575111", "class_list": "", "function": "Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation., [UniProtKB, UniProtKB]; CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology., [RefSeq, PubMed]; Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression., [RefSeq, PubMed]; These findings elucidate the roles of CMTM4 in male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K143", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0009101 glycoprotein biosynthetic process;GO:0002523 leukocyte migration involved in inflammatory response;GO:0008104 intracellular protein localization;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CJ61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K249-1", "uniprot_id": [ { "id": "CLM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K249", "type": "external" } ], "mass": 21822.0, "length": 196, "protein_name": "CMRF35-like molecule 2", "gene_name": "Cd300e", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 2 precursor", "refseq_ac": [ { "id": "NP_742047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742047", "type": "external" } ], "gene_names_uniprotkb": "Cd300e; Cd300le; Clm2", "gene_names_refseq": "CLM2; Cd300e; Cd300le; TREM5", "protein_names_uniprotkb": "CMRF35-like molecule 2; CD300 antigen-like family member E; CLM-2", "protein_names_refseq": "CD300 antigen like family member E; CD300e antigen; CMRF-35-like molecule-1; CMRF35-like molecule 2 precursor; CMRF35-like molecule 2; immune receptor expressed on myeloid cells 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217306); (R-MMU-198933); (R-MMU-2172127)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14662855;18250455;29358324;34428180", "class_list": "", "function": "Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12), [RefSeq, PubMed]; Probably acts as an activating receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019811 cocaine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K249-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBZ3-1", "uniprot_id": [ { "id": "CLPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBZ3", "type": "external" } ], "mass": 75291.0, "length": 664, "protein_name": "Putative lipid scramblase CLPTM1", "gene_name": "Clptm1", "organism": "Mouse", "refseq_name": "putative lipid scramblase CLPTM1", "refseq_ac": [ { "id": "NP_062623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062623", "type": "external" } ], "gene_names_uniprotkb": "Clptm1; N14", "gene_names_refseq": "Clptm1; HS9; N14", "protein_names_uniprotkb": "Putative lipid scramblase CLPTM1; Cleft lip and palate transmembrane protein 1 homolog; Thymic epithelial cell surface antigen", "protein_names_refseq": "cleft lip and palate transmembrane protein 1 homolog; putative lipid scramblase CLPTM1; thymic epithelial cell surface antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:56457)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16479539;29395912;30899004;31219806;34203471;34428180;36210013;40885482;9218588;9828125", "class_list": "", "function": "Involved in GABAergic but not glutamatergic transmission (PubMed:29395912). Binds and traps GABAA receptors in the endoplasmic reticulum (ER) (PubMed:29395912). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors (PubMed:29395912). Altered GABAergic signaling is one among many causes of cleft palate (PubMed:29395912). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity). May play a role in T-cell development (PubMed:9218588)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Study shows that in complement to other GABAAR-associated proteins that promote receptor surface expression, Clptm1 limits GABAAR forward trafficking and regulates inhibitory homeostatic plasticity., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O08708;Q3U758;Q3U823;Q3UG77;Q8VEJ6", "ec_number_list": [], "go_molecular_function": "GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0007613 memory;GO:0030154 cell differentiation;GO:0048167 regulation of synaptic plasticity;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8VBZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC23-1", "uniprot_id": [ { "id": "CK086_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC23", "type": "external" } ], "mass": 14068.0, "length": 124, "protein_name": "Uncharacterized protein C11orf86 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf86 homolog", "refseq_ac": [ { "id": "NP_081513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081513", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2010003K11Rik; Faci; Nrnp1", "protein_names_uniprotkb": "Uncharacterized protein C11orf86 homolog", "protein_names_refseq": "nutritionally regulated nuclear protein 1; uncharacterized protein C11orf86 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69861)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8F7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VC23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCE4-1", "uniprot_id": [ { "id": "CI040_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCE4", "type": "external" } ], "mass": 17985.0, "length": 163, "protein_name": "Uncharacterized protein C9orf40 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C9orf40 homolog isoform 2", "refseq_ac": [ { "id": "NP_808308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808308", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "D030056L22Rik", "protein_names_uniprotkb": "Uncharacterized protein C9orf40 homolog", "protein_names_refseq": "uncharacterized protein C9orf40 homolog isoform 2; uncharacterized protein C9orf40 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:225995)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VN2-1", "uniprot_id": [ { "id": "CK071_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VN2", "type": "external" } ], "mass": 12629.0, "length": 117, "protein_name": "Uncharacterized protein C11orf71 homolog", "gene_name": "Gm5617", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf71 homolog", "refseq_ac": [ { "id": "NP_001004191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004191", "type": "external" } ], "gene_names_uniprotkb": "Gm5617", "gene_names_refseq": "EG434402; Gm5617", "protein_names_uniprotkb": "Uncharacterized protein C11orf71 homolog", "protein_names_refseq": "uncharacterized protein C11orf71 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:434402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNP8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91VN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N4-1", "uniprot_id": [ { "id": "CLD16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925N4", "type": "external" } ], "mass": 26100.0, "length": 235, "protein_name": "Claudin-16", "gene_name": "Cldn16", "organism": "Mouse", "refseq_name": "claudin-16", "refseq_ac": [ { "id": "NP_444471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444471", "type": "external" } ], "gene_names_uniprotkb": "Cldn16", "gene_names_refseq": "Cldn16; PCLN1; claudin-16", "protein_names_uniprotkb": "Claudin-16; Paracellin-1", "protein_names_refseq": "H59D2a protein; claudin-16; paracellin-1", "tax_id": 10090, "disease": "renal hypomagnesemia 3 (Disease Ontology:DOID:0060880); hypertension (Disease Ontology:DOID:10763); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (mmu:114141)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11729235;17442678;28028216;36889572", "class_list": "", "function": "Data suggest that claudin-16 forms a non-selective paracellular cation channel, rather than a selective Mg(2+)/Ca(2+) channel as previously proposed, [RefSeq, PubMed]; Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:17442678, PubMed:28028216)., [UniProtKB, UniProtKB, PubMed, PubMed]; Overexpression of CLDN16 in ovarian cancer is modulated by PI3K and PKC pathways., [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542L7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0030165 PDZ domain binding;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0051928 positive regulation of calcium ion transport;GO:0070293 renal absorption;GO:0070633 transepithelial transport;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q925N4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ52-1", "uniprot_id": [ { "id": "CEL3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ52", "type": "external" } ], "mass": 28905.0, "length": 269, "protein_name": "Chymotrypsin-like elastase family member 3B", "gene_name": "Cela3b", "organism": "Mouse", "refseq_name": "chymotrypsin-like elastase family member 3B precursor", "refseq_ac": [ { "id": "NP_080695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080695", "type": "external" } ], "gene_names_uniprotkb": "Cela3b; Ela3b; Ela3", "gene_names_refseq": "0910001F22Rik; 2310074F01Rik; Cela3b; Ela3b; Ela3", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 3B; 3.4.21.70; Elastase IIIB; Elastase-3B; Protease E", "protein_names_refseq": "chymotrypsin-like elastase family member 3B precursor; elastase 3, pancreatic; elastase 3B, pancreatic; elastase IIIB; elastase-3B; protease E", "tax_id": 10090, "disease": "", "pathway": " (mmu:67868)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Efficient protease with alanine specificity but only little elastolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNI0;Q9D7T9", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQ52-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ82-1", "uniprot_id": [ { "id": "CENPR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ82", "type": "external" } ], "mass": 20026.0, "length": 176, "protein_name": "Centromere protein R", "gene_name": "Itgb3bp", "organism": "Mouse", "refseq_name": "centromere protein R isoform 1", "refseq_ac": [ { "id": "NP_080624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080624", "type": "external" } ], "gene_names_uniprotkb": "Itgb3bp; Cenpr; Nrif3", "gene_names_refseq": "4930471O16Rik; CENP-R; Itgb3bp", "protein_names_uniprotkb": "Centromere protein R; CENP-R; Nuclear receptor-interacting factor 3", "protein_names_refseq": "centromere protein R isoform 1; centromere protein R; nuclear receptor-interacting factor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67733); (R-MMU-141430); (R-MMU-141444); (R-MMU-205043); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "15381392;28795467;31112734", "class_list": "", "function": "In contrast to uPAR or NF-kappaB, the expression of beta(3)-endonexin was reduced in extracts of advanced atherosclerotic aortic tissue, [RefSeq, PubMed]; These results indicate Cenp-r functions bilaterally in cancer development: during early developmental stages, Cenp-r functions as a tumor suppressor, but during the expansion and progression of papillomas it functions as a tumor-promoting factor, [RefSeq, PubMed]; Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLR0;Q3TNR4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR86-1", "uniprot_id": [ { "id": "CHSP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR86", "type": "external" } ], "mass": 16062.0, "length": 148, "protein_name": "Calcium-regulated heat stable protein 1", "gene_name": "Carhsp1", "organism": "Mouse", "refseq_name": "calcium-regulated heat stable protein 1", "refseq_ac": [ { "id": "NP_080097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080097", "type": "external" } ], "gene_names_uniprotkb": "Carhsp1", "gene_names_refseq": "1200011K09Rik; Carhsp1; Crhsp-24; D16Ertd465e", "protein_names_uniprotkb": "Calcium-regulated heat stable protein 1; CRHSP-24; Calcium-regulated heat-stable protein of 24 kDa", "protein_names_refseq": "calcineurin substrate CRHSP-24; calcium-regulated heat stable protein 1; calcium-regulated heat-stable protein of 24 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:52502)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;19131326;21078874;21183079;25153642;28135057;28528544;31219806;34428180;37507081;39927985", "class_list": "", "function": "Binds mRNA and regulates the stability of target mRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0043186 P granule", "go_biological_process": "GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CR86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX66-1", "uniprot_id": [ { "id": "NOPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX66", "type": "external" } ], "mass": 19967.0, "length": 185, "protein_name": "NOP protein chaperone 1", "gene_name": "Nopchap1", "organism": "Mouse", "refseq_name": "NOP protein chaperone 1", "refseq_ac": [ { "id": "NP_080855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080855", "type": "external" } ], "gene_names_uniprotkb": "Nopchap1; D10Wsu102e", "gene_names_refseq": "C430041I18Rik; D10Wsu102e; Nopchap1", "protein_names_uniprotkb": "NOP protein chaperone 1", "protein_names_refseq": "NOP protein chaperone 1; uncharacterized protein C12orf45 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:28109)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;32782141;40885482", "class_list": "", "function": "Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS58;Q3TV68", "ec_number_list": [], "go_molecular_function": "GO:0062064 box C/D methylation guide snoRNP complex binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CX66-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXF7-1", "uniprot_id": [ { "id": "CHD1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXF7", "type": "external" } ], "mass": 101438.0, "length": 900, "protein_name": "ATP-dependent chromatin remodeler CHD1L", "gene_name": "Chd1l", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD1L isoform 1", "refseq_ac": [ { "id": "NP_080815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080815", "type": "external" } ], "gene_names_uniprotkb": "Chd1l", "gene_names_refseq": "4432404A22Rik; Alc1; Chd1l; Snf2p", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1L; 3.6.4.-; Chromo domain-containing protein 1-like", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD1L isoform 1; ATP-dependent chromatin remodeler CHD1L; amplified in liver cancer 1; chromo domain-containing protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:68058); (R-MMU-5696395); (R-MMU-5696400)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "19701453;25605945;26201266;27100146;28946814;30084848;30779550;31219806;33333017;34428180;35820727", "class_list": "", "function": "ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin., [UniProtKB, UniProtKB]; Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD., [RefSeq, PubMed]; Found a significant correlation of CHD1L with developmental transcriptional factors and lineage differentiation markers in clinical hepatocellular carcinoma patients, [RefSeq, PubMed]; Our data strongly support that CHD1L is a novel oncogene and plays an important role in hepatocellular carcinoma pathogenesis GeneRIF: Reports that transgenic CHD1L (Alc1) expression induces spontaneous tumors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of CHD1L in embryonic cells upregulated the expression of ectoderm genes, especially PAX6, [RefSeq, PubMed]; These results identify CHD1L as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMX1;Q6P5C0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016887 ATP hydrolysis activity;GO:0031491 nucleosome binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CXF7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ69-1", "uniprot_id": [ { "id": "CKLF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ69", "type": "external" } ], "mass": 19824.0, "length": 183, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 6", "gene_name": "Cmtm6", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 6 isoform 1", "refseq_ac": [ { "id": "NP_080312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080312", "type": "external" } ], "gene_names_uniprotkb": "Cmtm6; Cklfsf6", "gene_names_refseq": "2810051A14Rik; Cklfsf6; Cmtm6", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 6; Chemokine-like factor superfamily member 6", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 6 isoform 1; CKLF-like MARVEL transmembrane domain-containing protein 6; chemokine-like factor super family 6; chemokine-like factor superfamily 6; chemokine-like factor superfamily member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67213); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32908139;33434185;36165231;38101607;38165704", "class_list": "", "function": "CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis., [RefSeq, PubMed]; CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3beta axis. Publication Status: Online-Only, [RefSeq, PubMed]; CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves. Publication Status: Online-Only, [RefSeq, PubMed]; CMTM6 promotes hepatocellular carcinoma progression through stabilizing beta-catenin., [RefSeq, PubMed]; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy., [UniProtKB, UniProtKB]; Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7C3;Q922J1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0006955 immune response;GO:0015031 protein transport;GO:0031647 regulation of protein stability;GO:0060480 lung goblet cell differentiation;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CZ69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7Z6-1", "uniprot_id": [ { "id": "CLCA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7Z6", "type": "external" } ], "mass": 100071.0, "length": 913, "protein_name": "Calcium-activated chloride channel regulator 1", "gene_name": "Clca1", "organism": "Mouse", "refseq_name": "calcium-activated chloride channel regulator 1 precursor", "refseq_ac": [ { "id": "NP_059502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059502", "type": "external" } ], "gene_names_uniprotkb": "Clca1; Clca3; Gob5", "gene_names_refseq": "Clca1; Clca2; Clca3; gob-5; gob5", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 1; 3.4.-.-; Calcium-activated chloride channel family member 3; Protein gob-5; mCLCA3", "protein_names_refseq": "calcium-activated chloride channel family member 3; calcium-activated chloride channel regulator 1 precursor; calcium-activated chloride channel regulator 1; chloride channel calcium activated 1; chloride channel calcium activated 2; chloride channel calcium activated 3; mCLCA3; protein gob-5", "tax_id": 10090, "disease": "cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:23844); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10049711;11296262;11694454;12019299;12568493;15919655;16099848;16251409;16645179;16895902;25428506;35820727;38593125;38597420", "class_list": "", "function": "CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome., [RefSeq, PubMed]; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC., [UniProtKB, PubMed, PubMed, PubMed]; Niflumic acid treatment during natural antigen-exposure, where mCLCA3 is greatly up-regulated in the lung, significantly reduces airway inflammation, goblet cell metaplasia and mucus overproduction in vivo., [RefSeq, PubMed]; Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O88826;Q8R049", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030141 secretory granule;GO:0005902 microvillus", "go_biological_process": "GO:0006508 proteolysis;GO:0006816 calcium ion transport;GO:0071456 cellular response to hypoxia;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D7Z6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8L0-1", "uniprot_id": [ { "id": "CK052_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8L0", "type": "external" } ], "mass": 14283.0, "length": 127, "protein_name": "Uncharacterized protein C11orf52 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf52 homolog", "refseq_ac": [ { "id": "NP_080141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080141", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2310030G06Rik; 2610024D04Rik", "protein_names_uniprotkb": "Uncharacterized protein C11orf52 homolog", "protein_names_refseq": "uncharacterized protein C11orf52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CPS4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030054 cell junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D8L0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8N1-1", "uniprot_id": [ { "id": "CK024_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8N1", "type": "external" } ], "mass": 41095.0, "length": 392, "protein_name": "Uncharacterized protein C11orf24 homolog", "gene_name": "1810055G02Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf24 homolog precursor", "refseq_ac": [ { "id": "NP_082353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082353", "type": "external" } ], "gene_names_uniprotkb": "1810055G02Rik", "gene_names_refseq": "1810055G02Rik", "protein_names_uniprotkb": "Uncharacterized protein C11orf24 homolog", "protein_names_refseq": "uncharacterized protein C11orf24 homolog precursor; uncharacterized protein C11orf24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72056)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCP2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D8N1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBL7-1", "uniprot_id": [ { "id": "COASY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBL7", "type": "external" } ], "mass": 62023.0, "length": 563, "protein_name": "Bifunctional coenzyme A synthase", "gene_name": "Coasy", "organism": "Mouse", "refseq_name": "bifunctional coenzyme A synthase isoform 1 precursor", "refseq_ac": [ { "id": "NP_001292911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292911", "type": "external" } ], "gene_names_uniprotkb": "Coasy; Ukr1", "gene_names_refseq": "1300003G02Rik; Coasy; Dpck; Ppat; Ukr1", "protein_names_uniprotkb": "Bifunctional coenzyme A synthase; CoA synthase; DPCOAK; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; PPAT; Pantetheine-phosphate adenylyltransferase", "protein_names_refseq": "4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase; CoA synthase; bifunctional coenzyme A synthase isoform 1 precursor; bifunctional coenzyme A synthase", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation 6 (Disease Ontology:DOID:0110740); pontocerebellar hypoplasia type 12 (Disease Ontology:DOID:0112327); mucopolysaccharidosis III (Disease Ontology:DOID:12801); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:71743); (R-MMU-196783)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11980892;23806337;31219806;33352696;34203471;34428180;36210013;37453647", "class_list": "", "function": "Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'-phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA., [UniProtKB, PubMed]; Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BFA8;Q3TVZ2;Q8K3Y4", "ec_number_list": [ { "id": "2.7.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.24", "type": "external" }, { "id": "2.7.7.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.3", "type": "external" } ], "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0004595 pantetheine-phosphate adenylyltransferase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DBL7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESD6-1", "uniprot_id": [ { "id": "CKLF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESD6", "type": "external" } ], "mass": 18105.0, "length": 167, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 7", "gene_name": "Cmtm7", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2", "refseq_ac": [ { "id": "NP_001239408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239408", "type": "external" } ], "gene_names_uniprotkb": "Cmtm7; Cklfsf7; Lnv", "gene_names_refseq": "Cklfsf7; Cmtm7; LNV", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 7; Chemokine-like factor superfamily member 7; LNV", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2; CKLF-like MARVEL transmembrane domain-containing protein 7; chemokine-like factor super family 7; chemokine-like factor superfamily member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:102545)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22363743;24080084;31081901;32022930;32305130", "class_list": "", "function": "CMTM7 functions to link sIgM and BLNK in the plasma membrane., [RefSeq, PubMed]; CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells., [RefSeq, PubMed]; Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igmu repertoire of splenic B-1a cells., [RefSeq, PubMed]; The Cmtm7 deficiency resulted in a slow proliferation and high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a cell development at the transitional stage., [RefSeq, PubMed]; The reduction of B-1a cells in Cmtm7(flox/) mice was associated with reduced BCR expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHW2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006935 chemotaxis;GO:0002437 inflammatory response to antigenic stimulus;GO:0042113 B cell activation;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXK3-1", "uniprot_id": [ { "id": "COPG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXK3", "type": "external" } ], "mass": 97681.0, "length": 871, "protein_name": "Coatomer subunit gamma-2", "gene_name": "Copg2", "organism": "Mouse", "refseq_name": "coatomer subunit gamma-2 isoform 1", "refseq_ac": [ { "id": "NP_059506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059506", "type": "external" } ], "gene_names_uniprotkb": "Copg2", "gene_names_refseq": "Copg2; gamma-2-COP", "protein_names_uniprotkb": "Coatomer subunit gamma-2; Gamma-2-COP; Gamma-2-coat protein", "protein_names_refseq": "coatomer subunit gamma-2 isoform 1; coatomer subunit gamma-2; gamma-2-coat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:54160); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10788617;11032317;17360540;19892989;20173027;25428506;30084848;30779550;31219806;33300544;34428180;35820727", "class_list": "", "function": "Copg2 gene, closely linked to Mest/Peg1 gene on chr 6, is paternally imprinted., [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6J5;Q3TQD5;Q3UEL6;Q8C2J6", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030426 growth cone;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0072384 organelle transport along microtubule;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QXK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYM8-1", "uniprot_id": [ { "id": "CENPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYM8", "type": "external" } ], "mass": 28135.0, "length": 241, "protein_name": "Centromere protein H", "gene_name": "Cenph", "organism": "Mouse", "refseq_name": "centromere protein H isoform 1", "refseq_ac": [ { "id": "NP_068686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068686", "type": "external" } ], "gene_names_uniprotkb": "Cenph; Enp", "gene_names_refseq": "1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik; CENP-H; Cenph; ENP", "protein_names_uniprotkb": "Centromere protein H; CENP-H", "protein_names_refseq": "centromere autoantigen H; centromere protein H isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26886); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "10488063;19232519;25605945;27993978", "class_list": "", "function": "A novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/C(Cdh1)-cyclin B1 pathway., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3K9;Q9D079;Q9D0N1", "ec_number_list": [], "go_molecular_function": "GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0051383 kinetochore organization;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBV7-1", "uniprot_id": [ { "id": "CSN8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBV7", "type": "external" } ], "mass": 23256.0, "length": 209, "protein_name": "COP9 signalosome complex subunit 8", "gene_name": "Cops8", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 8", "refseq_ac": [ { "id": "NP_598566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598566", "type": "external" } ], "gene_names_uniprotkb": "Cops8; Csn8", "gene_names_refseq": "9430009J09Rik; Cops8; Csn8; Sgn8", "protein_names_uniprotkb": "COP9 signalosome complex subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8; SGN8; Signalosome subunit 8", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; JAB1-containing signalosome subunit 8; signalosome subunit 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:108679); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "14636993;21750661;26383969;30084848;32848054;34428180;9707402", "class_list": "", "function": "CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins., [RefSeq, PubMed]; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRS9;Q80XF4;Q8R4D2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0007250 activation of NF-kappaB-inducing kinase activity;GO:0010387 COP9 signalosome assembly;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VBV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A6YXX9-1", "uniprot_id": [ { "id": "CTSEL_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0A6YXX9", "type": "external" } ], "mass": 89594.0, "length": 775, "protein_name": "Cation channel sperm-associated protein subunit epsilon-like protein", "gene_name": "Catspere2", "organism": "Mouse", "refseq_name": "cation channel sperm-associated protein subunit epsilon-like protein isoform b precursor", "refseq_ac": [ { "id": "NP_001030071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030071", "type": "external" } ], "gene_names_uniprotkb": "Catspere2; Gm16432", "gene_names_refseq": "Catspere2; Gm16432; Gm30473", "protein_names_uniprotkb": "Cation channel sperm-associated protein subunit epsilon-like protein; CatSper-epsilon-like; CatSperepsilon-like", "protein_names_refseq": "catSper-epsilon-like; catSperepsilon-like; cation channel sperm-associated protein subunit epsilon-like protein isoform b precursor; cation channel sperm-associated protein subunit epsilon-like protein; catsper channel auxiliary subunit epsilon 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:545391)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RW93;Q3V2N6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A6YXX9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URE8-1", "uniprot_id": [ { "id": "CTXN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URE8", "type": "external" } ], "mass": 8987.0, "length": 81, "protein_name": "Cortexin-2", "gene_name": "Ctxn2", "organism": "Mouse", "refseq_name": "cortexin-2", "refseq_ac": [ { "id": "NP_001156406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156406", "type": "external" } ], "gene_names_uniprotkb": "Ctxn2", "gene_names_refseq": "Ctxn2; Gm1638", "protein_names_uniprotkb": "Cortexin-2", "protein_names_refseq": "cortexin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381418)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3URE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83714-1", "uniprot_id": [ { "id": "CTF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P83714", "type": "external" } ], "mass": 22000.0, "length": 204, "protein_name": "Cardiotrophin-2", "gene_name": "Ctf2", "organism": "Mouse", "refseq_name": "cardiotrophin-2 precursor", "refseq_ac": [ { "id": "NP_942155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942155", "type": "external" } ], "gene_names_uniprotkb": "Ctf2; Gm494", "gene_names_refseq": "Ctf2; Gm494; NP", "protein_names_uniprotkb": "Cardiotrophin-2; CT-2; Neuropoietin; Np", "protein_names_refseq": "CT-2; cardiotrophin-2 precursor; neuropoietin", "tax_id": 10090, "disease": "", "pathway": " (mmu:244218)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15051883;18728012;20353755;21750661", "class_list": "", "function": "A new ligand for ciliary neurotrophic factor receptor alpha, with important implications for murine nervous system development, [RefSeq, PubMed]; Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain, [RefSeq, PubMed]; Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation., [UniProtKB]; Neuropoietin induced activation of STAT3 tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005127 ciliary neurotrophic factor receptor binding;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0007259 cell surface receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P83714-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXZ0-1", "uniprot_id": [ { "id": "CTXN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXZ0", "type": "external" } ], "mass": 8832.0, "length": 80, "protein_name": "Cortexin-3", "gene_name": "Ctxn3", "organism": "Mouse", "refseq_name": "cortexin-3", "refseq_ac": [ { "id": "NP_001128169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128169", "type": "external" } ], "gene_names_uniprotkb": "Ctxn3", "gene_names_refseq": "Ctxn3", "protein_names_uniprotkb": "Cortexin-3", "protein_names_refseq": "cortexin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:629147)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BXZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N16-1", "uniprot_id": [ { "id": "CP4F3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N16", "type": "external" } ], "mass": 59843.0, "length": 524, "protein_name": "Cytochrome P450 4F3", "gene_name": "Cyp4f18; Cyp4f3", "organism": "Mouse", "refseq_name": "cytochrome P450 4F3", "refseq_ac": [ { "id": "NP_077764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077764", "type": "external" } ], "gene_names_uniprotkb": "Cyp4f18; Cyp4f3; Cyp4f18", "gene_names_refseq": "1810054N16Rik; CYPIVF3; Cyp4f18; Cyp4f3; Cypf18", "protein_names_uniprotkb": "Cytochrome P450 4F3; CYPIVF3; Leukotriene-B(4) omega-1/omega-2 hydroxylase", "protein_names_refseq": "cytochrome P450 4F3; cytochrome P450 CYP4F18; cytochrome P450, 4f18; cytochrome P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 2; leukotriene-B(4) omega-1/omega-2 hydroxylase; leukotriene-B(4) omega-hydroxylase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72054); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691); (R-MMU-2142816)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "16380383;17081494;20173027;21750661;24632148;26613087;30084848;31219806;34320496;34428180;36210013;36374250", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of the pro-inflammatory lipid mediator leukotriene B4 (LTB4) (PubMed:16380383, PubMed:24632148). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation (PubMed:16380383, PubMed:24632148). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:16380383, PubMed:24632148)., [UniProtKB, PubMed, PubMed]; CYP4F18 is a critical protein in the regulation of LTB(4) metabolism, [RefSeq, PubMed]; CYP4F18-deficient neutrophils exhibit increased chemotaxis to complement component C5a., [RefSeq, PubMed]; Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis., [RefSeq, PubMed]; It is concluded that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes, [RefSeq, PubMed]; Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice., [RefSeq, PubMed]; The mRNA levels of Cyp4f18 increase with the development of allergic inflammation in the lung., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLZ3;Q9D8N4", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050051 leukotriene-B4 20-monooxygenase activity;GO:0008391 arachidonate monooxygenase activity;GO:0120319 long-chain fatty acid omega-1 hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019369 arachidonate metabolic process;GO:0036101 leukotriene B4 catabolic process;GO:0036102 leukotriene B4 metabolic process;GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99N16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04683-1", "uniprot_id": [ { "id": "CXCR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04683", "type": "external" } ], "mass": 42115.0, "length": 374, "protein_name": "C-X-C chemokine receptor type 5", "gene_name": "Cxcr5", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 5", "refseq_ac": [ { "id": "NP_031577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031577", "type": "external" } ], "gene_names_uniprotkb": "Cxcr5; Blr1; Gpcr6", "gene_names_refseq": "Blr1; CXC-R5; CXCR-5; Cxcr5; Gpcr6; MDR15", "protein_names_uniprotkb": "C-X-C chemokine receptor type 5; Burkitt lymphoma receptor 1 homolog; CXC-R5; CXCR-5", "protein_names_refseq": "C-X-C chemokine receptor type 5; burkitt lymphoma receptor 1 homolog; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:12145); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;26495903;39456064;8288218;8405054;8978608;9486651", "class_list": "", "function": "Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes., [UniProtKB]; Intrauterine adhesions repair with menstrual blood-derived mesenchymal stem cells via CXCL13-CXCR5 signal axis and its mechanism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3C2", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0042113 B cell activation;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04683-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60571-1", "uniprot_id": [ { "id": "CRHBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60571", "type": "external" } ], "mass": 36048.0, "length": 322, "protein_name": "Corticotropin-releasing hormone-binding protein", "gene_name": "Crhbp", "organism": "Mouse", "refseq_name": "corticotropin-releasing factor-binding protein precursor", "refseq_ac": [ { "id": "NP_940800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940800", "type": "external" } ], "gene_names_uniprotkb": "Crhbp", "gene_names_refseq": "CRH-BP; Crhbp", "protein_names_uniprotkb": "Corticotropin-releasing hormone-binding protein; CRF-BP; CRF-binding protein; CRH-BP; Corticotropin-releasing factor-binding protein", "protein_names_refseq": "CRF-BP; CRF-binding protein; corticotropin-releasing factor-binding protein precursor; corticotropin-releasing factor-binding protein", "tax_id": 10090, "disease": "opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:12919); (R-MMU-373080)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27641503;30084848;30899004;32813270;7556876", "class_list": "", "function": "Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy., [UniProtKB, UniProtKB, UniProtKB]; Sex differences in CRF1, CRF, and CRFBP expression in C57BL/6J mouse brain across the lifespan and in response to acute stress., [RefSeq, PubMed]; Specifically binds and inactivates the corticotropin-releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production (PubMed:27641503, PubMed:7556876). May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042277 peptide binding;GO:0051424 corticotropin-releasing hormone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030141 secretory granule", "go_biological_process": "GO:0002125 maternal aggressive behavior;GO:0035903 cellular response to immobilization stress;GO:0001659 temperature homeostasis;GO:0006954 inflammatory response;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88833-1", "uniprot_id": [ { "id": "CP4AA_MOUSE", "url": "https://www.uniprot.org/uniprot/O88833", "type": "external" } ], "mass": 58330.0, "length": 509, "protein_name": "Cytochrome P450 4A10", "gene_name": "Cyp4a10", "organism": "Mouse", "refseq_name": "cytochrome P450 4A10", "refseq_ac": [ { "id": "NP_034141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034141", "type": "external" } ], "gene_names_uniprotkb": "Cyp4a10; Cyp4a-10", "gene_names_refseq": "Cyp4a10; Cyp4a; D4Rp1; Msp-3; RP1", "protein_names_uniprotkb": "Cytochrome P450 4A10; 1.14.14.80; CYPIVA10; Cytochrome P450-LA-omega 1; Cytochrome P452; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "CYPIVA10; cytochrome P450 4A10; cytochrome P450, 4a10; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:13117); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "16691295;17112342;21750661;30084848;30779550;34428180;8031839", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (By similarity). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (By similarity) (PubMed:17112342). In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (By similarity). Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9-epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA. Displays substantially lower fatty acid omega-1 hydroxylase activity (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A976;Q9DCS5", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity;GO:0050051 leukotriene-B4 20-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88833-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21460-1", "uniprot_id": [ { "id": "CYTC_MOUSE", "url": "https://www.uniprot.org/uniprot/P21460", "type": "external" } ], "mass": 15531.0, "length": 140, "protein_name": "Cystatin-C", "gene_name": "Cst3", "organism": "Mouse", "refseq_name": "cystatin-C precursor", "refseq_ac": [ { "id": "NP_034106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034106", "type": "external" } ], "gene_names_uniprotkb": "Cst3", "gene_names_refseq": "Cst3; CysC", "protein_names_uniprotkb": "Cystatin-C; Cystatin-3", "protein_names_refseq": "cystatin-3; cystatin-C precursor", "tax_id": 10090, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); CST3-related cerebral amyloid angiopathy (Disease Ontology:DOID:0070027); age related macular degeneration 11 (Disease Ontology:DOID:0110023); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); iron deficiency anemia (Disease Ontology:DOID:11758); Guillain-Barre syndrome (Disease Ontology:DOID:12842); polyneuropathy (Disease Ontology:DOID:1389); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13010); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11471062;21750661;2241983;30899004;31219806;32152506;36288343;37828378;39147193;40885482;7835704", "class_list": "", "function": "As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity., [UniProtKB]; CST3 alleviates retinal vascular leakage by regulating the Rap1 signaling pathway., [RefSeq, PubMed]; The protein encoded by this gene is a cysteine protease inhibitor involved in neurodegenerative and cardiovascular processes. The encoded protein inhibits aggregation of beta-amyloid protein, a hallmark of Alzheimer's disease, so it may be useful as a therapeutic. This protein also may be a biomarker for atherosclerosis. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q544Y0", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030414 peptidase inhibitor activity;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006952 defense response;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P21460-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H666-1", "uniprot_id": [ { "id": "COX8C_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H666", "type": "external" } ], "mass": 8009.0, "length": 72, "protein_name": "Cytochrome c oxidase subunit 8C, mitochondrial", "gene_name": "Cox8c", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 8C, mitochondrial", "refseq_ac": [ { "id": "NP_001034138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034138", "type": "external" } ], "gene_names_uniprotkb": "Cox8c", "gene_names_refseq": "1700007F21Rik; COX8-3; COXVIII-3; Cox8c", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8C, mitochondrial; COX VIII-3; Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; Cytochrome c oxidase subunit 8-3", "protein_names_refseq": "COX VIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit 8C, mitochondrial; cytochrome c oxidase subunit VIIIc", "tax_id": 10090, "disease": "", "pathway": " (mmu:75483); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H666-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16563-1", "uniprot_id": [ { "id": "CRIS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P16563", "type": "external" } ], "mass": 27605.0, "length": 243, "protein_name": "Cysteine-rich secretory protein 2", "gene_name": "Crisp2", "organism": "Mouse", "refseq_name": "cysteine-rich secretory protein 2 precursor", "refseq_ac": [ { "id": "NP_001191000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191000", "type": "external" } ], "gene_names_uniprotkb": "Crisp2; Tpx-1; Tpx1", "gene_names_refseq": "CRISP-2; Crisp2; GAPDL5; Tpx-1; Tpx1", "protein_names_uniprotkb": "Cysteine-rich secretory protein 2; CRISP-2; Testis-specific protein TPX-1", "protein_names_refseq": "cysteine-rich secretory protein 2 precursor; testis specific gene 1; testis-specific protein TPX-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22024); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16339766;19686095;21750661;2613236;26786179;30759213", "class_list": "", "function": "Crisp2 genetic defects in sperm from humans and mice result in male infertility., [RefSeq, PubMed]; May regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation., [UniProtKB, PubMed]; We revealed a role for CRISP2 in establishing the ability of sperm to undergo the acrosome reaction and in establishing a normal flagellum waveform. Crisp2-deficient sperm possess a stiff midpiece and are thus unable to manifest the rapid form of progressive motility seen in wild type sperm. As a consequence, Crisp2-deficient males are subfertile., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16563-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8X1-1", "uniprot_id": [ { "id": "CUTC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8X1", "type": "external" } ], "mass": 29004.0, "length": 272, "protein_name": "Copper homeostasis protein cutC homolog", "gene_name": "Cutc", "organism": "Mouse", "refseq_name": "copper homeostasis protein cutC homolog isoform 1", "refseq_ac": [ { "id": "NP_001107034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107034", "type": "external" } ], "gene_names_uniprotkb": "Cutc", "gene_names_refseq": "2310039I18Rik; CGI-32; Cutc", "protein_names_uniprotkb": "Copper homeostasis protein cutC homolog", "protein_names_refseq": "copper homeostasis protein cutC homolog isoform 1; copper homeostasis protein cutC homolog; cutC copper transporter homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66388)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "May play a role in copper homeostasis. Can bind one Cu(1+) per subunit (By similarity)., [UniProtKB]; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D8X1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TKY6-1", "uniprot_id": [ { "id": "CWC27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TKY6", "type": "external" } ], "mass": 53543.0, "length": 469, "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "Cwc27", "organism": "Mouse", "refseq_name": "spliceosome-associated protein CWC27 homolog isoform 1", "refseq_ac": [ { "id": "NP_080348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080348", "type": "external" } ], "gene_names_uniprotkb": "Cwc27; Sdccag10", "gene_names_refseq": "3110009E13Rik; Cwc27; NY-CO-10; Sdccag10", "protein_names_uniprotkb": "Spliceosome-associated protein CWC27 homolog; PPIase CWC27; Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog", "protein_names_refseq": "CWC27 spliceosome-associated protein homolog; PPIase CWC27; PPIase SDCCAG10; peptidyl-prolyl cis-trans isomerase CWC27 homolog; peptidyl-prolyl cis-trans isomerase SDCCAG10; probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog; serologically defined colon cancer antigen 10; spliceosome-associated protein CWC27 homolog isoform 1; spliceosome-associated protein CWC27 homolog", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:67285); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28285769;34428180;34726245", "class_list": "", "function": "As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]; Cwc27, associated with retinal degeneration, functions as a splicing factor in vivo., [RefSeq, PubMed]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG42;Q8R158;Q9CXT1", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TKY6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4G1-1", "uniprot_id": [ { "id": "EPCIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4G1", "type": "external" } ], "mass": 25918.0, "length": 230, "protein_name": "Exosomal polycystin-1-interacting protein", "gene_name": "Epcip", "organism": "Mouse", "refseq_name": "polycystin-1-interacting protein 1 isoform X1", "refseq_ac": [ { "id": "XP_030105174", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_030105174", "type": "external" } ], "gene_names_uniprotkb": "Epcip; 4932438H23Rik", "gene_names_refseq": "4931406G06Rik; 4932438H23Rik; Epcip", "protein_names_uniprotkb": "Exosomal polycystin-1-interacting protein; Polycystin-1-interacting protein 1", "protein_names_refseq": "polycystin-1-interacting protein 1 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Likely to be involved with PKD1 in the detection, sequestration and exocytosis of senescent mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q544A2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0070062 extracellular exosome;GO:0140494 migrasome", "go_biological_process": "GO:0160040 mitocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JH7-1", "uniprot_id": [ { "id": "CSTN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JH7", "type": "external" } ], "mass": 105872.0, "length": 956, "protein_name": "Calsyntenin-3", "gene_name": "Clstn3", "organism": "Mouse", "refseq_name": "calsyntenin-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_705728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705728", "type": "external" } ], "gene_names_uniprotkb": "Clstn3; Cs3; Cstn3", "gene_names_refseq": "CSTN3; Clstn3b; Clstn3; Cs3; Cst-3; alc-beta", "protein_names_uniprotkb": "Calsyntenin-3; Alcadein-beta; Cst-3", "protein_names_refseq": "alcadein-beta; calsyntenin 3beta; calsyntenin-3 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:232370)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12498782;16760430;21750661;23499467;24094106;24613359;25428506;26495903;30899004;31043739;31219806;31599954;32382066;32434929;33101212;33672967;34418053;35279170;35420982;36477540;37884088;39488519", "class_list": "", "function": "Adipose-specific isoform that plays a key role in adaptive thermogenesis (PubMed:31043739, PubMed:36477540). Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization (PubMed:36477540). May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons (PubMed:31043739)., [UniProtKB, PubMed, PubMed]; Adipose-specific isoform that plays a key role in adaptive thermogenesis. Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization. May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons., [UniProtKB, UniProtKB]; CLSTN3B promotes lipid droplet maturation and lipid storage in mouse adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; CircAFF2 Promotes Neuronal Cell Injury in Intracerebral Hemorrhage by Regulating the miR-488/CLSTN3 Axis., [RefSeq, PubMed]; Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:24094106, PubMed:24613359, PubMed:32434929, PubMed:35420982). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane (PubMed:24094106, PubMed:24613359, PubMed:32434929). Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron (PubMed:35420982). May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2 (PubMed:33672967). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The C-terminal fragment but not full-length Cst-3 accumulated in dystrophic neurites surrounding amyloidbeta plaques in Tg2576 mouse and Alzheimer disease brains., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A4P8DYG6;Q544R0", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044232 organelle membrane contact site;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0010888 negative regulation of lipid storage;GO:1904861 excitatory synapse assembly;GO:0035249 synaptic transmission, glutamatergic;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q99JH7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70689-1", "uniprot_id": [ { "id": "CXB6_MOUSE", "url": "https://www.uniprot.org/uniprot/P70689", "type": "external" } ], "mass": 30366.0, "length": 261, "protein_name": "Gap junction beta-6 protein", "gene_name": "Gjb6", "organism": "Mouse", "refseq_name": "gap junction beta-6 protein", "refseq_ac": [ { "id": "NP_001010937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010937", "type": "external" } ], "gene_names_uniprotkb": "Gjb6; Cxn-30", "gene_names_refseq": "Cx30; Cxnf; D14Bwg0506e; Gjb6", "protein_names_uniprotkb": "Gap junction beta-6 protein; Connexin-30; Cx30", "protein_names_refseq": "connexin f; connexin-30; gap junction beta-6 protein; gap junction membrane channel protein beta 6", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal recessive nonsyndromic deafness 1B (Disease Ontology:DOID:0110476); autosomal dominant nonsyndromic deafness 3B (Disease Ontology:DOID:0110565); Clouston syndrome (Disease Ontology:DOID:14693); status epilepticus (Disease Ontology:DOID:1824); ectodermal dysplasia (Disease Ontology:DOID:2121); transient cerebral ischemia (Disease Ontology:DOID:224); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (mmu:14623); (R-MMU-190861)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19864490;21750661;32848054;34678516;8663509", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0048487 beta-tubulin binding;GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005884 actin filament;GO:0030054 cell junction;GO:0016324 apical plasma membrane;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0008285 negative regulation of cell population proliferation;GO:0055085 transmembrane transport;GO:0007605 sensory perception of sound;GO:0042471 ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70689-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03740-1", "uniprot_id": [ { "id": "CRGE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03740", "type": "external" } ], "mass": 21196.0, "length": 174, "protein_name": "Gamma-crystallin E", "gene_name": "Cryge", "organism": "Mouse", "refseq_name": "gamma-crystallin E isoform 1", "refseq_ac": [ { "id": "NP_031803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031803", "type": "external" } ], "gene_names_uniprotkb": "Cryge", "gene_names_refseq": "Cryg-2; Cryg-6; Cryge; DGcry-2; Elo", "protein_names_uniprotkb": "Gamma-crystallin E; Gamma-E-crystallin", "protein_names_refseq": "eye lens obsolescence; gamma-E-crystallin; gamma-crystallin E isoform 1; gamma-crystallin E", "tax_id": 10090, "disease": "cataract 4 multiple types (Disease Ontology:DOID:0110234); cataract 7 (Disease Ontology:DOID:0110260); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12968)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1916296;21750661;27517863;6096855", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O89028;P26999;Q9CXK5", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0034614 cellular response to reactive oxygen species;GO:0001654 eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q03740-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TCH7-1", "uniprot_id": [ { "id": "CUL4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TCH7", "type": "external" } ], "mass": 87753.0, "length": 759, "protein_name": "Cullin-4A", "gene_name": "Cul4a", "organism": "Mouse", "refseq_name": "cullin-4A isoform 1", "refseq_ac": [ { "id": "NP_666319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666319", "type": "external" } ], "gene_names_uniprotkb": "Cul4a", "gene_names_refseq": "2810470J21Rik; Cul4a", "protein_names_uniprotkb": "Cullin-4A; CUL-4A", "protein_names_refseq": "CUL-4A; cullin-4A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:99375); (R-MMU-110314); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-8951664)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12077329;12393421;16467204;20190741;21183079;21750661;24357321;25605945;31219806;34428180;37151881;37507081;38221594", "class_list": "", "function": "A Cul4A ubiquitin ligase positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 to accumulate and signal cell cycle exit, [RefSeq, PubMed]; A novel tRNA-derived fragment tRF-3023b suppresses inflammation in RAW264.7 cells by targeting Cul4a through NF-kappaB signaling. Publication Status: Online-Only, [RefSeq, PubMed]; CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc., [RefSeq, PubMed]; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(DTL) directs autoubiquitination of DTL. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1. The DCX(ERCC8) complex (also named CSA complex) plays a role in transcription-coupled repair (TCR). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. With CUL4B, contributes to ribosome biogenesis. The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes., [UniProtKB, UniProtKB]; Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation., [RefSeq, PubMed]; S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THM3;Q91Z44", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:2000819 regulation of nucleotide-excision repair;GO:0001701 in utero embryonic development;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q3TCH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAN8-1", "uniprot_id": [ { "id": "CST12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAN8", "type": "external" } ], "mass": 15036.0, "length": 128, "protein_name": "Cystatin-12", "gene_name": "Cst12", "organism": "Mouse", "refseq_name": "cystatin-12 precursor", "refseq_ac": [ { "id": "NP_081330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081330", "type": "external" } ], "gene_names_uniprotkb": "Cst12", "gene_names_refseq": "1700006F03Rik; CRES3; Cst12", "protein_names_uniprotkb": "Cystatin-12; Cystatin TE-1", "protein_names_refseq": "cystatin TE-1; cystatin-12 precursor; cystatin-related epididymal spermatogenic protein 3; cystatin-related gene expressed in testis and epididymis", "tax_id": 10090, "disease": "", "pathway": " (mmu:69362)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12444065;12586767;15972886;21750661;33384380", "class_list": "", "function": "CRES2 and CRES3 represent new members of a subgroup of cystatin family 2 proteins that likely carry out tissue-specific functions distinct from that of typical cystatins CRES2, CRES3], [RefSeq, PubMed]; CST12 protein may play a specialized role during spermatogenesis and sperm maturation, [RefSeq, PubMed]; Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Abeta assembly., [RefSeq, PubMed]; May play a specialized role in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAN8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4T1-1", "uniprot_id": [ { "id": "CYS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4T1", "type": "external" } ], "mass": 15506.0, "length": 145, "protein_name": "Cystin-1", "gene_name": "Cys1", "organism": "Mouse", "refseq_name": "cystin-1", "refseq_ac": [ { "id": "NP_001004455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004455", "type": "external" } ], "gene_names_uniprotkb": "Cys1", "gene_names_refseq": "2900006B19Rik; Ccap; Cys1; ck; cpk", "protein_names_uniprotkb": "Cystin-1; Cilia-associated protein", "protein_names_refseq": "cilia-associated protein; congenital polycystic kidneys; cystin cilia associated protein; cystin-1", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:12879)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11854326;19850956;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZP27;Q8R4T0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001822 kidney development;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R4T1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAN9-1", "uniprot_id": [ { "id": "CF97D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAN9", "type": "external" } ], "mass": 19775.0, "length": 164, "protein_name": "Sperm axonemal maintenance protein CFAP97D1", "gene_name": "Cfap97d1", "organism": "Mouse", "refseq_name": "sperm axonemal maintenance protein CFAP97D1", "refseq_ac": [ { "id": "NP_083563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083563", "type": "external" } ], "gene_names_uniprotkb": "Cfap97d1", "gene_names_refseq": "1700006E09Rik; Cfap97d1", "protein_names_uniprotkb": "Sperm axonemal maintenance protein CFAP97D1; CFAP97 domain-containing protein 1", "protein_names_refseq": "CFAP97 domain-containing protein 1; sperm axonemal maintenance protein CFAP97D1; uncharacterized protein C17orf105 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75437)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32785227", "class_list": "", "function": "Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. Publication Status: Online-Only, [RefSeq, PubMed]; Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54851-1", "uniprot_id": [ { "id": "CXD2_MOUSE", "url": "https://www.uniprot.org/uniprot/O54851", "type": "external" } ], "mass": 36082.0, "length": 321, "protein_name": "Gap junction delta-2 protein", "gene_name": "Gjd2", "organism": "Mouse", "refseq_name": "gap junction delta-2 protein", "refseq_ac": [ { "id": "NP_034420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034420", "type": "external" } ], "gene_names_uniprotkb": "Gjd2; Gja9", "gene_names_refseq": "Cxns; Gja9; Gjd2; connexin36; cx36", "protein_names_uniprotkb": "Gap junction delta-2 protein; Connexin-36; Cx36; Gap junction alpha-9 protein", "protein_names_refseq": "connexin s; connexin-36; gap junction alpha-9 protein; gap junction delta-2 protein; gap junction membrane channel protein alpha 9; gap junction protein, alpha 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:14617); (R-MMU-112303); (R-MMU-190861)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10876089;26241696;26483638;32547367;9753189", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDP3;Q9JII0", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0045202 synapse;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54851-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55038-1", "uniprot_id": [ { "id": "CXL13_MOUSE", "url": "https://www.uniprot.org/uniprot/O55038", "type": "external" } ], "mass": 11927.0, "length": 109, "protein_name": "C-X-C motif chemokine 13", "gene_name": "Cxcl13", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 13 precursor", "refseq_ac": [ { "id": "NP_061354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061354", "type": "external" } ], "gene_names_uniprotkb": "Cxcl13; Blc; Scyb13", "gene_names_refseq": "4631412M08Rik; ANGIE2; Angie; BCA-1; BLC; BLR1L; Cxcl13; Scyb13", "protein_names_uniprotkb": "C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13", "protein_names_refseq": "B lymphocyte chemoattractant; C-X-C motif chemokine 13 precursor; C-X-C motif chemokine 13; CXC chemokine BLC; chemokine (C-X-C motif) ligand 13; small inducible cytokine subfamily B (Cys-X-Cys), member 13; small-inducible cytokine B13", "tax_id": 10090, "disease": "", "pathway": " (mmu:55985); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "37936696;39151591;39456064;9486651", "class_list": "", "function": "CXCL13 promotes thermogenesis in mice via recruitment of M2 macrophage and inhibition of inflammation in brown adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Intrauterine adhesions repair with menstrual blood-derived mesenchymal stem cells via CXCL13-CXCR5 signal axis and its mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Matrix stiffness regulates the triad communication of adipocytes/macrophages/endothelial cells through CXCL13., [RefSeq, PubMed]; Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0048018 receptor ligand activity;GO:0017134 fibroblast growth factor binding;GO:0031724 CXCR5 chemokine receptor binding;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0032487 regulation of Rap protein signal transduction;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55038-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70333-1", "uniprot_id": [ { "id": "CRIPT_MOUSE", "url": "https://www.uniprot.org/uniprot/O70333", "type": "external" } ], "mass": 11271.0, "length": 101, "protein_name": "Cysteine-rich PDZ-binding protein", "gene_name": "Cript", "organism": "Mouse", "refseq_name": "cysteine-rich PDZ-binding protein", "refseq_ac": [ { "id": "NP_064320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064320", "type": "external" } ], "gene_names_uniprotkb": "Cript", "gene_names_refseq": "1200020A08Rik; Cript", "protein_names_uniprotkb": "Cysteine-rich PDZ-binding protein; Cysteine-rich interactor of PDZ three; Cysteine-rich interactor of PDZ3", "protein_names_refseq": "cysteine-rich PDZ-binding protein; cysteine-rich interactor of PDZ three; cysteine-rich interactor of PDZ3; postsynaptic protein Cript", "tax_id": 10090, "disease": "Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (mmu:56724)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17474715;26192747", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99LR6;Q9DBP4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0031122 cytoplasmic microtubule organization;GO:1902897 regulation of postsynaptic density protein 95 clustering;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70333-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88410-1", "uniprot_id": [ { "id": "CXCR3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88410", "type": "external" } ], "mass": 41018.0, "length": 367, "protein_name": "C-X-C chemokine receptor type 3", "gene_name": "Cxcr3", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 3", "refseq_ac": [ { "id": "NP_034040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034040", "type": "external" } ], "gene_names_uniprotkb": "Cxcr3; Cmkar3", "gene_names_refseq": "Cd183; Cmkar3; Cxcr3", "protein_names_uniprotkb": "C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; IP-10 receptor; Interferon-inducible protein 10 receptor", "protein_names_refseq": "C-X-C chemokine receptor type 3; IP-10 receptor; chemokine (C-X-C motif) receptor 3; interferon-inducible protein 10 receptor", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); dilated cardiomyopathy (Disease Ontology:DOID:12930); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:12766); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10201891;30084848;34203471;34428180;9653165;9790904", "class_list": "", "function": "Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Receptor for chemokine CCL21 (PubMed:10201891, PubMed:9653165). Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Y6;Q9QWN6", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019958 C-X-C chemokine binding;GO:0019956 chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88410-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00015-1", "uniprot_id": [ { "id": "CYC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P00015", "type": "external" } ], "mass": 11714.0, "length": 105, "protein_name": "Cytochrome c, testis-specific", "gene_name": "Cyct", "organism": "Mouse", "refseq_name": "cytochrome c, testis-specific", "refseq_ac": [ { "id": "NP_034119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034119", "type": "external" } ], "gene_names_uniprotkb": "Cyct", "gene_names_refseq": "Cyct; T-Cc", "protein_names_uniprotkb": "Cytochrome c, testis-specific", "protein_names_refseq": "cytochrome c, testis-specific", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (mmu:13067)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "240690;2834389", "class_list": "", "function": "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB]; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006915 apoptotic process;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0042743 hydrogen peroxide metabolic process;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P00015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00416-1", "uniprot_id": [ { "id": "COX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P00416", "type": "external" } ], "mass": 29923.0, "length": 261, "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "mt-Co3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "mt-Co3; COIII; Mtco3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 3; 7.1.1.9; Cytochrome c oxidase polypeptide III", "protein_names_refseq": "", "tax_id": 10090, "disease": "MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (mmu:17710); (R-MMU-5419276); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "12954771;33300544;34428180;34616041;38575788;7332926", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:34616041, PubMed:38575788). Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water (PubMed:34616041). Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)) (PubMed:34616041). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:34616041)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00416-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04345-1", "uniprot_id": [ { "id": "CRGA_MOUSE", "url": "https://www.uniprot.org/uniprot/P04345", "type": "external" } ], "mass": 21149.0, "length": 174, "protein_name": "Gamma-crystallin A", "gene_name": "Cryga", "organism": "Mouse", "refseq_name": "gamma-crystallin A", "refseq_ac": [ { "id": "NP_031800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031800", "type": "external" } ], "gene_names_uniprotkb": "Cryga", "gene_names_refseq": "Cryg-4; Cryga; DGcry-4; Secc", "protein_names_uniprotkb": "Gamma-crystallin A; Gamma-A-crystallin; Gamma-crystallin 4", "protein_names_refseq": "gamma-A-crystallin; gamma-crystallin 4; gamma-crystallin A", "tax_id": 10090, "disease": "cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12964)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "6096855;6330674", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Three main families of major soluble proteins, the alpha, beta and gamma crystallins, are ubiquitously expressed in vertebrate lenses. This gene encodes a member of the gamma-crystallin family of proteins which may function as a structural component of the eye lens. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Five gamma-crystallin genes (gamma-A through gamma-E) are tandemly organized in a genomic segment as a gene cluster in the mouse. Another gamma-crystallin gene (gamma-F) is found some distance upstream of the cluster on the same chromosome. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0001654 eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09920-1", "uniprot_id": [ { "id": "CSF3_MOUSE", "url": "https://www.uniprot.org/uniprot/P09920", "type": "external" } ], "mass": 22421.0, "length": 208, "protein_name": "Granulocyte colony-stimulating factor", "gene_name": "Csf3", "organism": "Mouse", "refseq_name": "granulocyte colony-stimulating factor precursor", "refseq_ac": [ { "id": "NP_034101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034101", "type": "external" } ], "gene_names_uniprotkb": "Csf3; Csfg", "gene_names_refseq": "Csf3; Csfg; G-CSF; MGI-IG", "protein_names_uniprotkb": "Granulocyte colony-stimulating factor; G-CSF", "protein_names_refseq": "granulocyte colony-stimulating factor precursor; granulocyte colony-stimulating factor", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); pleurisy (Disease Ontology:DOID:10247); allergic cutaneous vasculitis (Disease Ontology:DOID:11450); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); neutropenia (Disease Ontology:DOID:1227); cognitive disorder (Disease Ontology:DOID:1561); cystitis (Disease Ontology:DOID:1679); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); myeloid leukemia (Disease Ontology:DOID:8692); bacterial pneumonia (Disease Ontology:DOID:874); acute myeloid leukemia (Disease Ontology:DOID:9119); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12985); (R-MMU-9674555); (R-MMU-9705462)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "3489940;3494605;3501294;38145912", "class_list": "", "function": "Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes., [UniProtKB]; Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005130 granulocyte colony-stimulating factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0071682 endocytic vesicle lumen", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12790-1", "uniprot_id": [ { "id": "CP2B9_MOUSE", "url": "https://www.uniprot.org/uniprot/P12790", "type": "external" } ], "mass": 55741.0, "length": 491, "protein_name": "Cytochrome P450 2B9", "gene_name": "Cyp2b9", "organism": "Mouse", "refseq_name": "cytochrome P450 2B9 precursor", "refseq_ac": [ { "id": "NP_034130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034130", "type": "external" } ], "gene_names_uniprotkb": "Cyp2b9; Cyp2b-9; Rip", "gene_names_refseq": "Cyp2b9; Cyp2b", "protein_names_uniprotkb": "Cytochrome P450 2B9; 1.14.14.1; CYPIIB9; Cytochrome P450 clone PF26; Cytochrome P450-16-alpha; Testosterone 16-alpha hydroxylase", "protein_names_refseq": "16alphaoh-a; CYPIIB9; cytochrome P450 2B9 precursor; cytochrome P450 2B9; cytochrome P450 clone PF26; cytochrome P450, 2b9, phenobarbitol inducible, type a; cytochrome P450-16-alpha; phenobarbitol inducible, type a; testosterone 16-alpha hydroxylase", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13094)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1997326;23704697;3219345;34428180", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; Multiple microRNAs participated in the regulation of Cyp2b9 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64463", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0035634 response to stilbenoid;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12790-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18340-1", "uniprot_id": [ { "id": "CXCL9_MOUSE", "url": "https://www.uniprot.org/uniprot/P18340", "type": "external" } ], "mass": 14444.0, "length": 126, "protein_name": "C-X-C motif chemokine 9", "gene_name": "Cxcl9", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 9 precursor", "refseq_ac": [ { "id": "NP_032625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032625", "type": "external" } ], "gene_names_uniprotkb": "Cxcl9; Mig; Scyb9", "gene_names_refseq": "CMK; Cxcl9; Mig; MuMIG; Scyb9; crg-10", "protein_names_uniprotkb": "C-X-C motif chemokine 9; Gamma-interferon-induced monokine; MIG; Monokine induced by interferon-gamma; MuMIG; Protein m119; Small-inducible cytokine B9", "protein_names_refseq": "C-X-C motif chemokine 9 precursor; C-X-C motif chemokine 9; M119; chemokine (C-X-C motif) ligand 9; gamma interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma; protein m119; small inducible cytokine B subfamily (Cys-X-Cys), member 9; small-inducible cytokine B9", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); bronchiolitis obliterans (Disease Ontology:DOID:2799); severe acute respiratory syndrome (Disease Ontology:DOID:2945); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); pneumonia (Disease Ontology:DOID:552); extrinsic allergic alveolitis (Disease Ontology:DOID:841); chronic fatigue syndrome (Disease Ontology:DOID:8544); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:17329); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10393857;2115167;26495903;34428180;36655287;36708947;37516815", "class_list": "", "function": "CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts., [RefSeq, PubMed]; CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response., [UniProtKB]; Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway., [RefSeq, PubMed]; PTLD (posttransplant lymphoproliferative disease) tissues express significantly lower levels of Mig compared to lymphoid tissues diagnosed with acute EBV-induced infectious mononucleosis, as assessed by semiquantitative RT-PCR analysis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9J0;Q99J60", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18340-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18406-1", "uniprot_id": [ { "id": "CCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P18406", "type": "external" } ], "mass": 41709.0, "length": 379, "protein_name": "CCN family member 1", "gene_name": "Ccn1", "organism": "Mouse", "refseq_name": "CCN family member 1 precursor", "refseq_ac": [ { "id": "NP_034646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034646", "type": "external" } ], "gene_names_uniprotkb": "Ccn1; Cyr61; Igfbp10", "gene_names_refseq": "Ccn1; Cyr61; Igfbp10", "protein_names_uniprotkb": "CCN family member 1; 3CH61; Cellular communication network factor 1; Cysteine-rich angiogenic inducer 61; IBP-10; IGF-binding protein 10; IGFBP-10; Insulin-like growth factor-binding protein 10; Protein CYR61", "protein_names_refseq": "3CH61; CCN family member 1 precursor; CCN family member 1; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; insulin-like growth factor-binding protein 10; intermediate early; protein CYR61", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); peripheral artery disease (Disease Ontology:DOID:0050830); atrial heart septal defect 1 (Disease Ontology:DOID:0110106); intracranial aneurysm (Disease Ontology:DOID:10941); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); capillary hemangioma (Disease Ontology:DOID:2725); high grade glioma (Disease Ontology:DOID:3070); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:16007); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10821835;2062642;2355916;25428506;31599954;34428180;37828378", "class_list": "", "function": "Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18406-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24457-1", "uniprot_id": [ { "id": "CP2DB_MOUSE", "url": "https://www.uniprot.org/uniprot/P24457", "type": "external" } ], "mass": 56988.0, "length": 504, "protein_name": "Cytochrome P450 2D11", "gene_name": "Cyp2d11", "organism": "Mouse", "refseq_name": "cytochrome P450 2D11", "refseq_ac": [ { "id": "NP_001098001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098001", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d11; Cyp2d-11", "gene_names_refseq": "Cyp2d11; Cyp2d; P450-2D", "protein_names_uniprotkb": "Cytochrome P450 2D11; 1.14.14.1; CYPIID11; Cytochrome P450-16-alpha; Cytochrome P450CC; Testosterone 16-alpha hydroxylase", "protein_names_refseq": "CYPIID11; cytochrome P450 2D11; cytochrome P450, 2d11; cytochrome P450-16-alpha; cytochrome P450CC; testosterone 16-alpha hydroxylase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:545123)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2914938", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q750", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24457-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24622-1", "uniprot_id": [ { "id": "CRYAA_MOUSE", "url": "https://www.uniprot.org/uniprot/P24622", "type": "external" } ], "mass": 22489.0, "length": 196, "protein_name": "Alpha-crystallin A chain", "gene_name": "Cryaa", "organism": "Mouse", "refseq_name": "alpha-crystallin A chain isoform 2", "refseq_ac": [ { "id": "NP_038529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038529", "type": "external" } ], "gene_names_uniprotkb": "Cryaa; Crya1", "gene_names_refseq": "Acry-1; Crya-1; Crya1; Cryaa; DAcry-1; lop18", "protein_names_uniprotkb": "Alpha-crystallin A chain", "protein_names_refseq": "alpha-crystallin A chain isoform 2; alpha-crystallin A chain; crystallin, alpha 1; lens opacity 18", "tax_id": 10090, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 9 multiple types (Disease Ontology:DOID:0110266); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (mmu:12954)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;30016717;31219806;6187470;7156978;9695791", "class_list": "", "function": "Alpha A crystallin is a moonlighting protein that functions as a heat shock protein as well as a lens crystalline. Review article Erratum:[Prog Retin Eye Res 1999 Jul;18(4):552], [RefSeq, PubMed]; Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA., [UniProtKB, UniProtKB]; This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02490;P02496;P82532;Q61444;Q6LEL4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005198 structural molecule activity;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0006750 glutathione biosynthetic process;GO:0001934 positive regulation of protein phosphorylation;GO:0007015 actin filament organization;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P24622-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28235-1", "uniprot_id": [ { "id": "CXA4_MOUSE", "url": "https://www.uniprot.org/uniprot/P28235", "type": "external" } ], "mass": 37596.0, "length": 333, "protein_name": "Gap junction alpha-4 protein", "gene_name": "Gja4", "organism": "Mouse", "refseq_name": "gap junction alpha-4 protein", "refseq_ac": [ { "id": "NP_032146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032146", "type": "external" } ], "gene_names_uniprotkb": "Gja4; Cxn-37", "gene_names_refseq": "Cnx37; Cx37; Cxnh1; Gja-4; Gja4", "protein_names_uniprotkb": "Gap junction alpha-4 protein; Connexin-37; Cx37", "protein_names_refseq": "connexin h1; connexin-37; gap junction alpha-4 protein; gap junction membrane channel protein alpha 4", "tax_id": 10090, "disease": "coronary artery disease (Disease Ontology:DOID:3393); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:14612); (R-MMU-190861)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11004519;1651942;8164742", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006816 calcium ion transport;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28235-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32766-1", "uniprot_id": [ { "id": "CST8_MOUSE", "url": "https://www.uniprot.org/uniprot/P32766", "type": "external" } ], "mass": 16288.0, "length": 142, "protein_name": "Cystatin-8", "gene_name": "Cst8", "organism": "Mouse", "refseq_name": "cystatin-8 precursor", "refseq_ac": [ { "id": "NP_034108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034108", "type": "external" } ], "gene_names_uniprotkb": "Cst8; Cres", "gene_names_refseq": "Cres; Cst-rs1; Cst8", "protein_names_uniprotkb": "Cystatin-8; Cystatin-related epididymal spermatogenic protein; Cystatin-related epididymal-specific protein", "protein_names_refseq": "cystatin-8 precursor; cystatin-8; cystatin-related epididymal spermatogenic protein; cystatin-related epididymal-specific protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13012)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10229662;12479114;1280328;22827436;23185254;23269664;32601205;33384380", "class_list": "", "function": "A 14-kDa CRES isoform resides in the outer dense fibers of the sperm tail. Publication Status: Online-Only, [RefSeq, PubMed]; CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing. Review article, [RefSeq, PubMed]; CRES may be a regulator of PC4 in sperm-egg interaction and fertilization., [RefSeq, PubMed]; Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Abeta assembly., [RefSeq, PubMed]; Data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens, [RefSeq, PubMed]; Maturation of the functional mouse CRES amyloid from globular form., [RefSeq, PubMed]; Performs a specialized role during sperm development and maturation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O89102;Q543A7", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32766-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48772-1", "uniprot_id": [ { "id": "COX8B_MOUSE", "url": "https://www.uniprot.org/uniprot/P48772", "type": "external" } ], "mass": 7332.0, "length": 70, "protein_name": "Cytochrome c oxidase subunit 8B, mitochondrial", "gene_name": "Cox8b", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 8B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031777", "type": "external" } ], "gene_names_uniprotkb": "Cox8b; Cox8h", "gene_names_refseq": "Cox8b; Cox8h; CoxVIII-H", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8B, mitochondrial; Cytochrome c oxidase polypeptide VIII-heart; Cytochrome c oxidase subunit 8-1; Cytochrome c oxidase subunit 8H", "protein_names_refseq": "COX VIII-H; cytochrome c oxidase polypeptide VIII-heart; cytochrome c oxidase subunit 8-1; cytochrome c oxidase subunit 8B, mitochondrial precursor; cytochrome c oxidase subunit 8B, mitochondrial; cytochrome c oxidase subunit 8H; cytochrome c oxidase subunit VIII-H; cytochrome c oxidase subunit VIIIb", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12869)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "34616041;37507081;38575788;7711081", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48772-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50228-1", "uniprot_id": [ { "id": "CXCL5_MOUSE", "url": "https://www.uniprot.org/uniprot/P50228", "type": "external" } ], "mass": 14235.0, "length": 132, "protein_name": "C-X-C motif chemokine 5", "gene_name": "Cxcl5", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 5 precursor", "refseq_ac": [ { "id": "NP_033167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033167", "type": "external" } ], "gene_names_uniprotkb": "Cxcl5; Scyb5", "gene_names_refseq": "AMCF-II; Cxcl5; Cxcl6; ENA-78; GCP-2; LIX; Scyb5; Scyb6", "protein_names_uniprotkb": "C-X-C motif chemokine 5; Cytokine LIX; Small-inducible cytokine B5", "protein_names_refseq": "C-X-C motif chemokine 5 precursor; C-X-C motif chemokine 5; chemokine (C-X-C motif) ligand 5; cytokine LIX; granulocyte chemotactic protein-2; small inducible cytokine B subfamily, member 5; small inducible cytokine subfamily B, member 15; small-inducible cytokine B5", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); alcohol-associated liver disease (Disease Ontology:DOID:0070658); common cold (Disease Ontology:DOID:10459); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary sarcoidosis (Disease Ontology:DOID:13406); prostatitis (Disease Ontology:DOID:14654); colon carcinoma (Disease Ontology:DOID:1520); diffuse scleroderma (Disease Ontology:DOID:1580); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); colorectal cancer (Disease Ontology:DOID:9256); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:20311); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10570306;12439624;20643340;37942533;38627393;7622488;8759763", "class_list": "", "function": "CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation., [UniProtKB, PubMed]; MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5., [RefSeq, PubMed]; Regulates chemokine scavenging and pulmonary host defense to bacterial infection, [RefSeq, PubMed]; This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3I3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0010976 positive regulation of neuron projection development;GO:0032496 response to lipopolysaccharide;GO:0032642 regulation of chemokine production;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50228-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59055-1", "uniprot_id": [ { "id": "CSRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/P59055", "type": "external" } ], "mass": 66121.0, "length": 597, "protein_name": "Cysteine/serine-rich nuclear protein 3", "gene_name": "Csrnp3", "organism": "Mouse", "refseq_name": "cysteine/serine-rich nuclear protein 3 isoform b", "refseq_ac": [ { "id": "NP_001277594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277594", "type": "external" } ], "gene_names_uniprotkb": "Csrnp3; Fam130a2; Mbu1; Taip2", "gene_names_refseq": "A330102K23Rik; CSRNP-3; Csnrp3; Csrnp3; Mbu1; taip-2", "protein_names_uniprotkb": "Cysteine/serine-rich nuclear protein 3; CSRNP-3; Protein FAM130A2; TAIP-2; TGF-beta-induced apoptosis protein 2", "protein_names_refseq": "TGF-beta induced apoptosis protein 2; cysteine/serine-rich nuclear protein 3 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:77771)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17433858;17726538;18291095;21750661;23076708", "class_list": "", "function": "Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis., [UniProtKB, PubMed, PubMed]; CpG methylation converses with histone modifications in an opposing sense of regulating Mbu-1 expression, [RefSeq, PubMed]; The mbu-1 gene was only expressed in the brain and spinal cord during the embryonic stages, and throughout all regions of the adult brain, showing higher levels in the hippocampus and hypothalamus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3F6Q4;Q8BUT9;Q8BYL1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P59055-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70423-1", "uniprot_id": [ { "id": "CTR3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70423", "type": "external" } ], "mass": 67460.0, "length": 618, "protein_name": "Cationic amino acid transporter 3", "gene_name": "Slc7a3", "organism": "Mouse", "refseq_name": "cationic amino acid transporter 3", "refseq_ac": [ { "id": "NP_001288769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288769", "type": "external" } ], "gene_names_uniprotkb": "Slc7a3; Atrc3; Cat3", "gene_names_refseq": "Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2; Slc7a3", "protein_names_uniprotkb": "Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3", "protein_names_refseq": "amino acid transporter, cationic 3; cationic amino acid transporter 3; cationic amino acid transporter y+; solute carrier family 7 member 3", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666); lipid storage disease (Disease Ontology:DOID:9455)", "pathway": " (mmu:11989); (R-MMU-352230)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16085056;22872234;30865893;31599954;36528691;9334265", "class_list": "", "function": "Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors., [RefSeq, PubMed]; Slc7a3 expression is significantly induced by p53 upon glutamine deprivation., [RefSeq, PubMed]; The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]; Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9334265). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:9334265)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AVE2", "ec_number_list": [], "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0032006 regulation of TOR signaling;GO:0097638 L-arginine import across plasma membrane;GO:0097639 L-lysine import across plasma membrane;GO:0097640 L-ornithine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70423-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00977-1", "uniprot_id": [ { "id": "CXB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00977", "type": "external" } ], "mass": 26411.0, "length": 226, "protein_name": "Gap junction beta-2 protein", "gene_name": "Gjb2", "organism": "Mouse", "refseq_name": "gap junction beta-2 protein", "refseq_ac": [ { "id": "NP_032151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032151", "type": "external" } ], "gene_names_uniprotkb": "Gjb2; Cxn-26", "gene_names_refseq": "Cnx26; Cx26; Cxne; Gjb-2; Gjb2", "protein_names_uniprotkb": "Gap junction beta-2 protein; Connexin-26; Cx26", "protein_names_refseq": "connexin e; connexin-26; gap junction beta-2 protein; gap junction membrane channel protein beta 2", "tax_id": 10090, "disease": "Bart-Pumphrey syndrome (Disease Ontology:DOID:0050658); autosomal dominant keratitis-ichthyosis-deafness syndrome (Disease Ontology:DOID:0060871); autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal dominant nonsyndromic deafness 3A (Disease Ontology:DOID:0110564); Vohwinkel syndrome (Disease Ontology:DOID:0111339); palmoplantar keratoderma-deafness syndrome (Disease Ontology:DOID:0111505); sensorineural hearing loss (Disease Ontology:DOID:10003); urethral obstruction (Disease Ontology:DOID:12577); extrahepatic cholestasis (Disease Ontology:DOID:13619); ischemia (Disease Ontology:DOID:326); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:14619); (R-MMU-190872)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1322820;15692151;19864490;2060697;34428180;37681746", "class_list": "", "function": "Degradation of cochlear Connexin26 accelerate the development of age-related hearing loss., [RefSeq, PubMed]; Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0097449 astrocyte projection;GO:0044297 cell body", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0055085 transmembrane transport;GO:0007605 sensory perception of sound;GO:0048839 inner ear development;GO:0016264 gap junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00977-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02738-1", "uniprot_id": [ { "id": "CXB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02738", "type": "external" } ], "mass": 30389.0, "length": 266, "protein_name": "Gap junction beta-4 protein", "gene_name": "Gjb4", "organism": "Mouse", "refseq_name": "gap junction beta-4 protein isoform 1", "refseq_ac": [ { "id": "NP_032153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032153", "type": "external" } ], "gene_names_uniprotkb": "Gjb4; Cxn-30.3", "gene_names_refseq": "Cnx30.3; Cx30.3; Cxnb; Gjb-4; Gjb4", "protein_names_uniprotkb": "Gap junction beta-4 protein; Connexin-30.3; Cx30.3", "protein_names_refseq": "connexin b; connexin-30.3; gap junction beta-4 protein isoform 1; gap junction beta-4 protein; gap junction membrane channel protein beta 4", "tax_id": 10090, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); erythrokeratodermia variabilis et progressiva 2 (Disease Ontology:DOID:0080248)", "pathway": " (mmu:14621); (R-MMU-190861)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1512260;15692151;25428506;25428507;28205646;30084848;32565358;34428180", "class_list": "", "function": "Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells., [RefSeq, PubMed]; Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151)., [UniProtKB, PubMed, UniProtKB]; These indicate possible involvement of Cx30.3 in the rapid formation and/or decomposition of gap junctions; implying a functional relay between Cx30.3 and other systems such as adhesion proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0005922 connexin complex", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007267 cell-cell signaling;GO:0007608 sensory perception of smell;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02738-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03401-1", "uniprot_id": [ { "id": "CRIS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03401", "type": "external" } ], "mass": 27680.0, "length": 244, "protein_name": "Cysteine-rich secretory protein 1", "gene_name": "Crisp1", "organism": "Mouse", "refseq_name": "cysteine-rich secretory protein 1 precursor", "refseq_ac": [ { "id": "NP_033768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033768", "type": "external" } ], "gene_names_uniprotkb": "Crisp1; Aeg-1; Aeg1", "gene_names_refseq": "Aeg1; CRISP-1; Crisp1; SCP 1", "protein_names_uniprotkb": "Cysteine-rich secretory protein 1; Acidic epididymal glycoprotein 1; CRISP-1; SCP 1; Sperm-coating glycoprotein 1", "protein_names_refseq": "acidic epididymal glycoprotein 1; cysteine-rich secretory protein 1 precursor; sperm-coating glycoprotein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11571)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1301383;29670079;30510210;8319566", "class_list": "", "function": "These observations reveal that CRISP proteins are relevant for epididymal epithelium differentiation and male fertility, contributing to a better understanding of the fine-tuning mechanisms underlying sperm maturation and immunotolerance in the epididymis with clear implications for human epididymal physiology and pathology. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrated that the sustained level of AEG-1 as an important anti-apoptotic factor in nigral dopaminergic (DA) neurons might potentiate the therapeutic effects of treatments, such as Rheb(S16H) administration, on the degeneration of the DA pathway that characterizes Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0042581 specific granule;GO:0030133 transport vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q03401-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03402-1", "uniprot_id": [ { "id": "CRIS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03402", "type": "external" } ], "mass": 27314.0, "length": 241, "protein_name": "Cysteine-rich secretory protein 3", "gene_name": "Crisp3", "organism": "Mouse", "refseq_name": "cysteine-rich secretory protein 3 precursor", "refseq_ac": [ { "id": "NP_033769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033769", "type": "external" } ], "gene_names_uniprotkb": "Crisp3; Aeg-2; Aeg2", "gene_names_refseq": "Aeg2; CRISP-3; CRS3; Crisp3; SGP28", "protein_names_uniprotkb": "Cysteine-rich secretory protein 3; Acidic epididymal glycoprotein 2; CRISP-3; SCP 2; Sperm-coating glycoprotein 2", "protein_names_refseq": "SCP 2; acidic epididymal glycoprotein 2; cysteine-rich secretory protein 3 precursor; sperm-coating glycoprotein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:11572)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1301383;15461460;25715794;8319566", "class_list": "", "function": "These data suggest roles for epithelial and neutrophil-derived CRISP3 in endometrial repair and regeneration, [RefSeq, PubMed]; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RTK2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030133 transport vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q03402-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8T8-1", "uniprot_id": [ { "id": "CTP5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0V8T8", "type": "external" } ], "mass": 144260.0, "length": 1292, "protein_name": "Contactin-associated protein like 5-2", "gene_name": "Cntnap5b", "organism": "Mouse", "refseq_name": "contactin-associated protein like 5-2 precursor", "refseq_ac": [ { "id": "NP_766439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766439", "type": "external" } ], "gene_names_uniprotkb": "Cntnap5b; Caspr5-2", "gene_names_refseq": "C230078M14Rik; Caspr5-2; Cntnap5b", "protein_names_uniprotkb": "Contactin-associated protein like 5-2; Cell recognition molecule Caspr5-2; Cell recognition molecule Caspr5b; Contactin-associated protein-like 5b", "protein_names_refseq": "cell recognition molecule Caspr5-2; cell recognition molecule Caspr5b; contactin-associated protein like 5-2 precursor; contactin-associated protein like 5-2; contactin-associated protein-like 5b", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (mmu:241175)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16845472;18949514;21750661", "class_list": "", "function": "Caspr5-2 disruption leads to dysfunction at the cellular level rather than at the level of organ development., [RefSeq, PubMed]; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]; The three Caspr5 genes are located on chromosomes 1 & 17; all three paralogs are expressed; common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and & in the adult stage, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q2PAX9;Q8BUT8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0043005 neuron projection", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q0V8T8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8T9-1", "uniprot_id": [ { "id": "CTP5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0V8T9", "type": "external" } ], "mass": 145711.0, "length": 1304, "protein_name": "Contactin-associated protein like 5-1", "gene_name": "Cntnap5a", "organism": "Mouse", "refseq_name": "contactin-associated protein like 5-1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001070893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070893", "type": "external" } ], "gene_names_uniprotkb": "Cntnap5a; Caspr5-1", "gene_names_refseq": "Caspr5-1; Cntnap5a; EG636808", "protein_names_uniprotkb": "Contactin-associated protein like 5-1; Cell recognition molecule Caspr5-1; Cell recognition molecule Caspr5a; Contactin-associated protein-like 5a", "protein_names_refseq": "cell recognition molecule Caspr5-1; cell recognition molecule Caspr5a; contactin-associated protein like 5-1 isoform 2 precursor; contactin-associated protein like 5-1; contactin-associated protein-like 5a", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (mmu:636808)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16845472;30899004;33300544", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]; The three Caspr5 genes are located on chromosomes 1 & 17; all three paralogs are expressed; common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and & in the adult stage, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0043005 neuron projection", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q0V8T9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32P12-1", "uniprot_id": [ { "id": "HROB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32P12", "type": "external" } ], "mass": 66063.0, "length": 615, "protein_name": "Homologous recombination OB-fold protein", "gene_name": "Hrob", "organism": "Mouse", "refseq_name": "homologous recombination OB-fold protein", "refseq_ac": [ { "id": "NP_705772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705772", "type": "external" } ], "gene_names_uniprotkb": "Hrob", "gene_names_refseq": "Hrob", "protein_names_uniprotkb": "Homologous recombination OB-fold protein", "protein_names_refseq": "homologous recombination OB-fold protein; uncharacterized protein C17orf53 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:217216)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21952136;31467087;32782141;34707299;36852467", "class_list": "", "function": "DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis., [UniProtKB, UniProtKB]; Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AWS8;Q8CDN3", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0000725 recombinational repair;GO:0000731 DNA synthesis involved in DNA repair;GO:0007292 female gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q32P12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYP2-1", "uniprot_id": [ { "id": "CTRC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3SYP2", "type": "external" } ], "mass": 29470.0, "length": 268, "protein_name": "Chymotrypsin-C", "gene_name": "Ctrc", "organism": "Mouse", "refseq_name": "chymotrypsin-C precursor", "refseq_ac": [ { "id": "NP_001029047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029047", "type": "external" } ], "gene_names_uniprotkb": "Ctrc", "gene_names_refseq": "1810044E12Rik; Ctrc; caldecrin", "protein_names_uniprotkb": "Chymotrypsin-C; 3.4.21.2", "protein_names_refseq": "chymotrypsin-C precursor", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065)", "pathway": " (mmu:76701)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21471529;23814066;31211695;31973822", "class_list": "", "function": "Autoactivation of mouse trypsinogens is under the control of mouse Ctrc., [RefSeq, PubMed]; Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2., [RefSeq, PubMed]; Data show that ectopic expression of the caldecrin gene in the muscle of dy/dy mice reduced the level of blood urea nitrogen and improved the dystrophic progression similarly to that of caldecrin-injected mice., [RefSeq, PubMed]; Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors (By similarity). Has chymotrypsin-type protease activity and hypocalcemic activity (PubMed:23814066). Cleaves TRY4 and TRY5 and thereby inhibits their autoactivation (PubMed:23814066)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3SYP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THF9-1", "uniprot_id": [ { "id": "CQ10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THF9", "type": "external" } ], "mass": 27269.0, "length": 240, "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "Coq10b", "organism": "Mouse", "refseq_name": "coenzyme Q-binding protein COQ10 homolog B, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001034799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034799", "type": "external" } ], "gene_names_uniprotkb": "Coq10b", "gene_names_refseq": "1500041J02Rik; 1700030I21Rik; 9530077A17Rik; Coq10b", "protein_names_uniprotkb": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "protein_names_refseq": "coenzyme Q-binding protein COQ10 homolog B, mitochondrial isoform 1; coenzyme Q-binding protein COQ10 homolog B, mitochondrial; coenzyme Q10 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67876); (R-MMU-611105); (R-MMU-9864848)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18250455;18299400;20173027;21750661;25428506;25428507;25605945;30084848;34428180;37828378", "class_list": "", "function": "Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6N0;Q9D9R6", "ec_number_list": [], "go_molecular_function": "GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3THF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UST5-1", "uniprot_id": [ { "id": "CP089_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UST5", "type": "external" } ], "mass": 43079.0, "length": 385, "protein_name": "UPF0764 protein C16orf89 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0764 protein C16orf89 homolog isoform 1 precursor", "refseq_ac": [ { "id": "NP_001028392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028392", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "AU021092", "protein_names_uniprotkb": "UPF0764 protein C16orf89 homolog", "protein_names_refseq": "UPF0764 protein C16orf89 homolog isoform 1 precursor; UPF0764 protein C16orf89 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:239691)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20578903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZWC6", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UST5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJI2-1", "uniprot_id": [ { "id": "CTL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RJI2", "type": "external" } ], "mass": 81429.0, "length": 710, "protein_name": "Choline transporter-like protein 5", "gene_name": "Slc44a5", "organism": "Mouse", "refseq_name": "choline transporter-like protein 5", "refseq_ac": [ { "id": "NP_001074732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074732", "type": "external" } ], "gene_names_uniprotkb": "Slc44a5; Ctl5", "gene_names_refseq": "Gm422; Slc44a5", "protein_names_uniprotkb": "Choline transporter-like protein 5; Solute carrier family 44 member 5", "protein_names_refseq": "choline transporter-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:242259); (R-MMU-1483191); (R-MMU-9958517)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB]; Choline/H+ antiporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RJI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5UW37-1", "uniprot_id": [ { "id": "CXL17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5UW37", "type": "external" } ], "mass": 13627.0, "length": 119, "protein_name": "C-X-C motif chemokine 17", "gene_name": "Cxcl17", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 17 precursor", "refseq_ac": [ { "id": "NP_705804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705804", "type": "external" } ], "gene_names_uniprotkb": "Cxcl17; Vcc1", "gene_names_refseq": "Cxcl17; VCC-1; Vcc1", "protein_names_uniprotkb": "C-X-C motif chemokine 17; 13.6 kDa protein; 6-Cys CXCL17; VEGF coregulated chemokine 1", "protein_names_refseq": "13.6-kDa protein; 6-Cys CXCL17; C-X-C motif chemokine 17 precursor; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1; chemokine (C-X-C motif) ligand 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:232983)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16989774;22952881;24973458;30860634;38298146;39251671", "class_list": "", "function": "CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues as a major regulator of inflammatory responses., [RefSeq, PubMed]; CXCL17 is a proinflammatory chemokine and promotes neutrophil trafficking., [RefSeq, PubMed]; Characterization of prostate macrophage heterogeneity, foam cell markers, and CXCL17 upregulation in a mouse model of steroid hormone imbalance. Publication Status: Online-Only, [RefSeq, PubMed]; Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells, and which is involved in immune regulation and lymphocyte trafficking (PubMed:24973458, PubMed:38298146). Activates the C-X-C chemokine receptor GPR25 (By similarity). Plays a key role in lymphocyte homing by activating the receptor GPR25 on lymphocytes, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (By similarity). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774). Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17., [UniProtKB, UniProtKB]; These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis., [RefSeq, PubMed]; VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types[VCC-1], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5UW37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64448-1", "uniprot_id": [ { "id": "CXA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64448", "type": "external" } ], "mass": 46321.0, "length": 417, "protein_name": "Gap junction alpha-3 protein", "gene_name": "Gja3", "organism": "Mouse", "refseq_name": "gap junction alpha-3 protein", "refseq_ac": [ { "id": "NP_001258552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258552", "type": "external" } ], "gene_names_uniprotkb": "Gja3", "gene_names_refseq": "Cnx46; Cx43; Cx46; Cxnj1; Gja-3; Gja3", "protein_names_uniprotkb": "Gap junction alpha-3 protein; Connexin-46; Cx46", "protein_names_refseq": "alpha 3 connexin; connexin j1; connexin-46; gap junction alpha-3 protein; gap junction membrane channel protein alpha 3", "tax_id": 10090, "disease": "cataract 14 multiple types (Disease Ontology:DOID:0110253); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:14611); (R-MMU-190861)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "36139360;38359484", "class_list": "", "function": "Connexins 30 and 43 expression changes in relation to age-related hearing loss., [RefSeq, PubMed]; Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRM1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0042542 response to hydrogen peroxide;GO:0007601 visual perception;GO:0009268 response to pH;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64448-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DIA7-1", "uniprot_id": [ { "id": "BRME1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DIA7", "type": "external" } ], "mass": 64440.0, "length": 600, "protein_name": "Break repair meiotic recombinase recruitment factor 1", "gene_name": "Brme1", "organism": "Mouse", "refseq_name": "break repair meiotic recombinase recruitment factor 1 isoform 2", "refseq_ac": [ { "id": "NP_001157224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157224", "type": "external" } ], "gene_names_uniprotkb": "Brme1; 4930432K21Rik; Meiok21", "gene_names_refseq": "4930432K21Rik; Brme1; MRM; Mamerr; Meiok21", "protein_names_uniprotkb": "Break repair meiotic recombinase recruitment factor 1", "protein_names_refseq": "BRCA2 and MEILB2-associating protein 1; break repair meiotic recombinase recruitment factor 1 isoform 2; meiotic recombination modulator; uncharacterized protein C19orf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74666)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;25428506;27802388;32345962;32460033;32463460;32845237;33250349", "class_list": "", "function": "BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex. Publication Status: Online-Only, [RefSeq, PubMed]; Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair (PubMed:32460033, PubMed:32463460). Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination (PubMed:32460033, PubMed:32463460). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:32460033, PubMed:32463460)., [UniProtKB, PubMed, PubMed, PubMed]; The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J144;E9QNR8;Q9D5J2", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6DIA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEE2-1", "uniprot_id": [ { "id": "CTIF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PEE2", "type": "external" } ], "mass": 67831.0, "length": 600, "protein_name": "CBP80/20-dependent translation initiation factor", "gene_name": "Ctif", "organism": "Mouse", "refseq_name": "CBP80/20-dependent translation initiation factor isoform 2", "refseq_ac": [ { "id": "NP_958742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958742", "type": "external" } ], "gene_names_uniprotkb": "Ctif; Gm672; Kiaa0427", "gene_names_refseq": "Ctif; Gm672", "protein_names_uniprotkb": "CBP80/20-dependent translation initiation factor", "protein_names_refseq": "CBP80/20-dependent translation initiation factor isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:269037)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19648179;21750661;34428180", "class_list": "", "function": "Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6A069", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PEE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PG95-1", "uniprot_id": [ { "id": "CRML_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PG95", "type": "external" } ], "mass": 137121.0, "length": 1285, "protein_name": "Protein cramped-like", "gene_name": "Cramp1", "organism": "Mouse", "refseq_name": "protein cramped-like", "refseq_ac": [ { "id": "NP_065633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065633", "type": "external" } ], "gene_names_uniprotkb": "Cramp1; Cramp1l; Hn1l; Kiaa1426; Tce4", "gene_names_refseq": "5830477H08Rik; Cramp1l; Cramp1; Tce4; mKIAA1426", "protein_names_uniprotkb": "Protein cramped-like; Cramped chromatin regulator homolog 1; Hematological and neurological expressed 1-like protein", "protein_names_refseq": "Crm, cramped-like; cramped chromatin regulator homolog 1; hematological and neurological expressed 1-like protein; protein cramped-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:57354)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34592200;35820727", "class_list": "", "function": "Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers., [RefSeq, PubMed]; Transcription factor, which specifically drives expression of histone H1 genes. Binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x) together with NPAT and GON4L, positively regulating their transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNA8;Q6ZPR3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0035363 histone locus body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PG95-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q6R3-3", "uniprot_id": [ { "id": "CRIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Q6R3", "type": "external" } ], "mass": 22611.0, "length": 204, "protein_name": "Cysteine-rich protein 3", "gene_name": "Crip3", "organism": "Mouse", "refseq_name": "cysteine-rich protein 3 isoform TLP-B", "refseq_ac": [ { "id": "NP_444480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444480", "type": "external" } ], "gene_names_uniprotkb": "Crip3; Tlp", "gene_names_refseq": "Crip3; TLP-A; TLP-B; TLP; Tlmp", "protein_names_uniprotkb": "Cysteine-rich protein 3; CRP-3; Thymus LIM protein; m17TLP", "protein_names_refseq": "CRP-3; cysteine-rich protein 3 isoform TLP-B; m17TLP; thymus LIM protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:114570)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11713292;15380775", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q860;Q14B40;Q91V23;Q91V60", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042098 T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6Q6R3-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RUT7-1", "uniprot_id": [ { "id": "UQCC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RUT7", "type": "external" } ], "mass": 15348.0, "length": 136, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 4", "gene_name": "Uqcc4", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 4 precursor", "refseq_ac": [ { "id": "NP_898973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898973", "type": "external" } ], "gene_names_uniprotkb": "Uqcc4; Ccsmst1", "gene_names_refseq": "Ccsmst1; Uqcc4", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 4; Protein CCSMST1", "protein_names_refseq": "protein CCSMST1; ubiquinol-cytochrome c reductase complex assembly factor 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:214489)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31219806;34428180;35977508;37828378", "class_list": "", "function": "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6RUT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6S5G4-1", "uniprot_id": [ { "id": "CXA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6S5G4", "type": "external" } ], "mass": 32660.0, "length": 283, "protein_name": "Gap junction alpha-6 protein", "gene_name": "Gja6", "organism": "Mouse", "refseq_name": "gap junction alpha-6 protein", "refseq_ac": [ { "id": "NP_001001496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001496", "type": "external" } ], "gene_names_uniprotkb": "Gja6", "gene_names_refseq": "A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6; Gja6", "protein_names_uniprotkb": "Gap junction alpha-6 protein; Connexin-33; Cx33", "protein_names_refseq": "connexin k2; connexin-33; gap junction alpha-6 protein; gap junction membrane channel protein alpha 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:414089)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20152878", "class_list": "", "function": "Findings demonstrate that the interaction of Cx33 with Cx43 within a same heteromeric complex may conduce to channel instability through alteration of the phosphorylation status of Cx43 independently of the control of the c-Src kinase, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFY9;Q8BLZ9", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0010644 cell communication by electrical coupling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6S5G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810W6-1", "uniprot_id": [ { "id": "CXCR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810W6", "type": "external" } ], "mass": 40032.0, "length": 351, "protein_name": "C-X-C chemokine receptor type 1", "gene_name": "Cxcr1", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 1", "refseq_ac": [ { "id": "NP_839972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839972", "type": "external" } ], "gene_names_uniprotkb": "Cxcr1; Il8ra", "gene_names_refseq": "Cxcr1; Il8ra", "protein_names_uniprotkb": "C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8R A", "protein_names_refseq": "C-X-C chemokine receptor type 1; CXC chemokine receptor 1; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha", "tax_id": 10090, "disease": "urinary tract infection (Disease Ontology:DOID:0080784); pyelonephritis (Disease Ontology:DOID:11400); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:227288); (R-MMU-380108); (R-MMU-418594); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15967374;16084593;17197447;36325326;37207443;37709757", "class_list": "", "function": "CXCR1 and its downstream NF-kappaB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8 in mouse, [RefSeq, PubMed]; IL-10 in combination with IL-12 and TNF-alpha attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway., [RefSeq, PubMed]; MCXCR1 may mediate the recruitment of neutrophils to the inflammation site under certain infections, [RefSeq, PubMed]; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB]; The gene encoding mCXCR1-like was mapped to mouse chromosome 1 and its genomic organization was determined to be very similar to the organization of the gene encoding hCXCR1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019959 interleukin-8 binding;GO:0004918 interleukin-8 receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0097648 G protein-coupled receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q810W6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG15-1", "uniprot_id": [ { "id": "CTSL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG15", "type": "external" } ], "mass": 52813.0, "length": 465, "protein_name": "CTD small phosphatase-like protein 2", "gene_name": "Ctdspl2", "organism": "Mouse", "refseq_name": "CTD small phosphatase-like protein 2 isoform b", "refseq_ac": [ { "id": "NP_001277920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277920", "type": "external" } ], "gene_names_uniprotkb": "Ctdspl2; D2Ertd485e; Scp4", "gene_names_refseq": "Ctdspl2; D2Ertd485e; SCP4", "protein_names_uniprotkb": "CTD small phosphatase-like protein 2; 3.1.3.16; CTDSP-like 2; SCP4; Small C-terminal domain phosphatase 4; Small CTD phosphatase 4", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; CTD small phosphatase-like protein 2 isoform b; CTD small phosphatase-like protein 2; CTDSP-like 2; small C-terminal domain phosphatase 4; small CTD phosphatase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:329506)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;25100727;28506762;28851713;31219806;34428180;36210013;38886174", "class_list": "", "function": "Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation., [RefSeq, PubMed]; Regulator of FoxO transcription factors and promotes cellular proteolysis, [RefSeq, PubMed]; SCP4, is a Smad phosphatase and plays a critical role in BMP-induced signaling and cellular functions., [RefSeq, PubMed]; Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A within the nucleus, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis (PubMed:28851713). Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3 (PubMed:38886174). By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation (PubMed:38886174)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARL6;Q3TF86;Q3TQW7;Q3TV36;Q7TPZ9;Q8BPR3;Q8C9S0;Q8CEG6", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0046827 positive regulation of protein export from nucleus;GO:0030514 negative regulation of BMP signaling pathway;GO:0006470 protein dephosphorylation;GO:0060348 bone development;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BG15-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGQ2-1", "uniprot_id": [ { "id": "CSRN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGQ2", "type": "external" } ], "mass": 58504.0, "length": 534, "protein_name": "Cysteine/serine-rich nuclear protein 2", "gene_name": "Csrnp2", "organism": "Mouse", "refseq_name": "cysteine/serine-rich nuclear protein 2", "refseq_ac": [ { "id": "NP_700456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700456", "type": "external" } ], "gene_names_uniprotkb": "Csrnp2; Fam130a1; Taip12", "gene_names_refseq": "CSRNP-2; Csnrp2; Csrnp2; taip-12", "protein_names_uniprotkb": "Cysteine/serine-rich nuclear protein 2; CSRNP-2; Protein FAM130A1; TAIP-12; TGF-beta-induced apoptosis protein 12", "protein_names_refseq": "TGF-beta induced apoptosis protein 12; cysteine/serine-rich nuclear protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:207785)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17726538;31599954", "class_list": "", "function": "Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May play a role in apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIH1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BT60-1", "uniprot_id": [ { "id": "CPNE3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BT60", "type": "external" } ], "mass": 59585.0, "length": 533, "protein_name": "Copine-3", "gene_name": "Cpne3", "organism": "Mouse", "refseq_name": "copine-3 isoform 1", "refseq_ac": [ { "id": "NP_082045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082045", "type": "external" } ], "gene_names_uniprotkb": "Cpne3; Kiaa0636", "gene_names_refseq": "5430428M23Rik; 5730450C07Rik; CPN3; Cpne3", "protein_names_uniprotkb": "Copine-3; Copine III", "protein_names_refseq": "copine-3 isoform 1; copine-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70568); (R-MMU-1483206); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21183079;26740625;28528544;31219806;34203471;34428180;40684658", "class_list": "", "function": "Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]., [RefSeq]; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5CZX9;Q5DU22", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0046872 metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071277 cellular response to calcium ion;GO:0071363 cellular response to growth factor stimulus;GO:0038128 ERBB2 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BT60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWG9-1", "uniprot_id": [ { "id": "ORAI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWG9", "type": "external" } ], "mass": 33062.0, "length": 304, "protein_name": "Calcium release-activated calcium channel protein 1", "gene_name": "Orai1", "organism": "Mouse", "refseq_name": "calcium release-activated calcium channel protein 1", "refseq_ac": [ { "id": "NP_780632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780632", "type": "external" } ], "gene_names_uniprotkb": "Orai1; Cracm1; Tmem142a", "gene_names_refseq": "D730049H07Rik; Orai1; Tmem142a; orai-1", "protein_names_uniprotkb": "Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A", "protein_names_refseq": "calcium release-activated calcium channel 1; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A", "tax_id": 10090, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 2 (Disease Ontology:DOID:0080686); immunodeficiency 9 (Disease Ontology:DOID:0111976); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:109305)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17224452;23840669;38516893;38637233", "class_list": "", "function": "Deletion of myeloid-specific Orai1 calcium channel does not affect pancreatic tissue damage in experimental acute pancreatitis., [RefSeq, PubMed]; Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion Erratum:[J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald [corrected to Gill, Donald L]], [RefSeq, PubMed]; ORAI1 inhibition as an efficient preclinical therapy for tubular aggregate myopathy and Stormorken syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (By similarity). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (By similarity). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (By similarity). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (PubMed:23840669)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUD4;Q8R586", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030426 growth cone;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0051924 regulation of calcium ion transport;GO:0002250 adaptive immune response;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BWG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX07-1", "uniprot_id": [ { "id": "CTDS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX07", "type": "external" } ], "mass": 30546.0, "length": 270, "protein_name": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2", "gene_name": "Ctdsp2", "organism": "Mouse", "refseq_name": "carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a", "refseq_ac": [ { "id": "NP_001106941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106941", "type": "external" } ], "gene_names_uniprotkb": "Ctdsp2", "gene_names_refseq": "Ctdsp2; D10Ertd73e; OS-4; OS4; SCP2", "protein_names_uniprotkb": "Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; 3.1.3.16; SCP2; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4); small C-terminal domain phosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52468)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15681389;25990325;34428180", "class_list": "", "function": "CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras., [RefSeq, PubMed]; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0006470 protein dephosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BX07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZQ2-1", "uniprot_id": [ { "id": "CRLD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZQ2", "type": "external" } ], "mass": 55432.0, "length": 495, "protein_name": "Cysteine-rich secretory protein LCCL domain-containing 2", "gene_name": "Crispld2", "organism": "Mouse", "refseq_name": "cysteine-rich secretory protein LCCL domain-containing 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001297564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297564", "type": "external" } ], "gene_names_uniprotkb": "Crispld2", "gene_names_refseq": "1810049K24Rik; Crispld2; Lcrisp2; Lgl1; coffeecrisp", "protein_names_uniprotkb": "Cysteine-rich secretory protein LCCL domain-containing 2; Coffeecrisp", "protein_names_refseq": "cysteine-rich secretory protein LCCL domain-containing 2 isoform 1 precursor", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567)", "pathway": " (mmu:78892); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17616516;18757743", "class_list": "", "function": "CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. Erratum:[Hum Mol Genet. 2008 Apr 1;17(7):1061. Arco-Burgos, Mauricio [corrected to Arcos-Burgos, Mauricio]], [RefSeq, PubMed]; Promotes matrix assembly., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4C7;Q9D2R3", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0030133 transport vesicle", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0060325 face morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BZQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHL5-1", "uniprot_id": [ { "id": "CRGN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHL5", "type": "external" } ], "mass": 21392.0, "length": 183, "protein_name": "Gamma-crystallin N", "gene_name": "Crygn", "organism": "Mouse", "refseq_name": "gamma-crystallin N", "refseq_ac": [ { "id": "NP_694716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694716", "type": "external" } ], "gene_names_uniprotkb": "Crygn", "gene_names_refseq": "Crygn", "protein_names_uniprotkb": "Gamma-crystallin N; Gamma-N-crystallin", "protein_names_refseq": "gamma-N-crystallin; gamma-crystallin N", "tax_id": 10090, "disease": "", "pathway": " (mmu:214301)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15853812;27517863", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens (Probable). Also plays an important role for integrity and function of auditory nuclei (PubMed:27517863)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IJ73;Q0VAU5", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WE4-1", "uniprot_id": [ { "id": "CR032_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WE4", "type": "external" } ], "mass": 8036.0, "length": 72, "protein_name": "UPF0729 protein C18orf32 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0729 protein C18orf32 homolog isoform 1", "refseq_ac": [ { "id": "NP_001001181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001181", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "BC031181", "protein_names_uniprotkb": "UPF0729 protein C18orf32 homolog", "protein_names_refseq": "UPF0729 protein C18orf32 homolog isoform 1; UPF0729 protein C18orf32 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:407819)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate the NF-kappa-B signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3U8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91WE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XD7-1", "uniprot_id": [ { "id": "CREL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XD7", "type": "external" } ], "mass": 45718.0, "length": 420, "protein_name": "Protein disulfide isomerase Creld1", "gene_name": "Creld1", "organism": "Mouse", "refseq_name": "protein disulfide isomerase Creld1 precursor", "refseq_ac": [ { "id": "NP_598691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598691", "type": "external" } ], "gene_names_uniprotkb": "Creld1", "gene_names_refseq": "Creld1; i11E7", "protein_names_uniprotkb": "Protein disulfide isomerase Creld1; 5.3.4.1; Cysteine-rich with EGF-like domain protein 1", "protein_names_refseq": "cysteine-rich with EGF-like domain protein 1; protein disulfide isomerase Creld1 precursor; protein disulfide isomerase Creld1", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); heart septal defect (Disease Ontology:DOID:1681)", "pathway": " (mmu:171508)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12137942;21750661;24697899;30407909;30899004;31219806;33773996;34418053;34428180;36210013;40997131", "class_list": "", "function": "Creld1 regulates myocardial development and function., [RefSeq, PubMed]; Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling., [RefSeq, PubMed]; Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed:30407909)., [UniProtKB, PubMed, UniProtKB]; Protein disulfide isomerase. Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGJ8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q91XD7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YD1-1", "uniprot_id": [ { "id": "CXD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YD1", "type": "external" } ], "mass": 30220.0, "length": 278, "protein_name": "Gap junction delta-3 protein", "gene_name": "Gjd3", "organism": "Mouse", "refseq_name": "gap junction delta-3 protein", "refseq_ac": [ { "id": "NP_848711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848711", "type": "external" } ], "gene_names_uniprotkb": "Gjd3; Gja11; Gjc1", "gene_names_refseq": "Cxnr; Gja11; Gjc1; Gjd3; cx30.2", "protein_names_uniprotkb": "Gap junction delta-3 protein; Connexin-30.2; Cx30.2; Gap junction alpha-11 protein; Gap junction chi-1 protein", "protein_names_refseq": "connexin 30.2; connexin r; gap junction alpha-11 protein; gap junction chi-1 protein; gap junction delta-3 protein; gap junction membrane channel protein chi 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:353155); (R-MMU-190861)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12108537;12681499;15879306;16571663", "class_list": "", "function": "Cx30.2 contributes to the slowdown of impulse propagation in the atrioventricular node and limits the maximum number of beats conducted from atria to ventricles, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; The electrical properties of homo- and hetero-typic junctions involving mCx30.2 may contribute to slow propagation velocity in nodal tissues and directional asymmetry of excitation spread in the AV nodal region., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZH0", "ec_number_list": [], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0009986 cell surface;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010459 negative regulation of heart rate;GO:0009749 response to glucose;GO:0086053 AV node cell to bundle of His cell communication by electrical coupling;GO:0016264 gap junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920C1-1", "uniprot_id": [ { "id": "CRDL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920C1", "type": "external" } ], "mass": 50732.0, "length": 447, "protein_name": "Chordin-like protein 1", "gene_name": "Chrdl1", "organism": "Mouse", "refseq_name": "chordin-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001107857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107857", "type": "external" } ], "gene_names_uniprotkb": "Chrdl1; Ng1; Nrln1", "gene_names_refseq": "CHL1; CHL; Chrdl1; Nrln1; VOPT", "protein_names_uniprotkb": "Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin", "protein_names_refseq": "chordin-like protein 1 isoform 1 precursor; chordin-like protein 1; neuralin-1; neurogenesin-1; ventroptin-alpha; ventroptin-beta", "tax_id": 10090, "disease": "megalocornea (Disease Ontology:DOID:0060305)", "pathway": " (mmu:83453); (R-MMU-201451); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11118896;11441185;16630536;21750661;36682027;36831292", "class_list": "", "function": "Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3., [RefSeq, PubMed]; Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q924K0;Q9EPZ9", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0098976 excitatory chemical synaptic transmission;GO:0030154 cell differentiation;GO:0048167 regulation of synaptic plasticity;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q920C1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923L3-1", "uniprot_id": [ { "id": "CSMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923L3", "type": "external" } ], "mass": 387862.0, "length": 3564, "protein_name": "CUB and sushi domain-containing protein 1", "gene_name": "Csmd1", "organism": "Mouse", "refseq_name": "CUB and sushi domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_444401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444401", "type": "external" } ], "gene_names_uniprotkb": "Csmd1", "gene_names_refseq": "B930082H09; Csmd1; mKIAA1890", "protein_names_uniprotkb": "CUB and sushi domain-containing protein 1; CUB and sushi multiple domains protein 1", "protein_names_refseq": "CUB and sushi domain-containing protein 1 precursor; CUB and sushi domain-containing protein 1; CUB and sushi multiple domains protein 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:94109)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11472063;23284669;30899004;33300544;38552925;38561856", "class_list": "", "function": "CSMD1 regulates brain complement activity and circuit development., [RefSeq, PubMed]; Effect of deleting CSMD1 on mouse behavior, [RefSeq, PubMed]; Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 27, "predicted_n_glycosites": 24, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 16, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 16, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 16, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 16, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 1, "glyco_site_count": 43, "binding_glycan_count": 0, "secondary_ac_list": "E9QK23;Q8BUV1;Q8BYQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0060745 mammary gland branching involved in pregnancy;GO:0001964 startle response;GO:0007613 memory;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q923L3-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ89-1", "uniprot_id": [ { "id": "CUTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ89", "type": "external" } ], "mass": 18865.0, "length": 177, "protein_name": "Protein CutA", "gene_name": "Cuta", "organism": "Mouse", "refseq_name": "protein CutA isoform 1 precursor", "refseq_ac": [ { "id": "NP_080583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080583", "type": "external" } ], "gene_names_uniprotkb": "Cuta", "gene_names_refseq": "0610039D01Rik; 1810022E02Rik; 1810060C03Rik; 2700094G22Rik; Cuta", "protein_names_uniprotkb": "Protein CutA; Brain acetylcholinesterase putative membrane anchor", "protein_names_refseq": "brain acetylcholinesterase putative membrane anchor; divalent cation tolerant protein CUTA; protein CutA isoform 1 precursor; protein CutA", "tax_id": 10090, "disease": "", "pathway": " (mmu:67675)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19645739;21750661;34428180", "class_list": "", "function": "An N-terminal CutA domain actually drives AChE into the endoplasmic reticulum and allows its secretion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXB6;Q8CI44;Q9D1L4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWL8-1", "uniprot_id": [ { "id": "CTBL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWL8", "type": "external" } ], "mass": 64980.0, "length": 563, "protein_name": "Beta-catenin-like protein 1", "gene_name": "Ctnnbl1", "organism": "Mouse", "refseq_name": "beta-catenin-like protein 1", "refseq_ac": [ { "id": "NP_079956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079956", "type": "external" } ], "gene_names_uniprotkb": "Ctnnbl1", "gene_names_refseq": "5730471K09Rik; Ctnnbl1; NAP; NYD-SP19; P14L", "protein_names_uniprotkb": "Beta-catenin-like protein 1; NAP; Nuclear-associated protein", "protein_names_refseq": "beta-catenin-like protein 1; nuclear protein NAP; nuclear-associated protein", "tax_id": 10090, "disease": "immunodeficiency 99 (Disease Ontology:DOID:0061069); morbid obesity (Disease Ontology:DOID:11981); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66642); (R-MMU-72163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12659813;20585033;21385873;23343763;34428180", "class_list": "", "function": "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31, [RefSeq, PubMed]; CTNNBL1 plays no essential role in cycling cells but does fulfill an evolutionarily conserved function in helping cells to undergo efficient exit from quiescence following activation., [RefSeq, PubMed]; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:20585033)., [UniProtKB, UniProtKB, PubMed]; Normal levels of immunoglobulin class switch recombination (CSR) factors are found in DTNNBL1-deficient cells, indicating that CTNNBL1 is dispensable for CSR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL41;Q80X64;Q8VHE3", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0002250 adaptive immune response;GO:0016445 somatic diversification of immunoglobulins;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CWL8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX80-1", "uniprot_id": [ { "id": "CYGB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX80", "type": "external" } ], "mass": 21466.0, "length": 190, "protein_name": "Cytoglobin", "gene_name": "Cygb", "organism": "Mouse", "refseq_name": "cytoglobin isoform 1", "refseq_ac": [ { "id": "NP_084482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084482", "type": "external" } ], "gene_names_uniprotkb": "Cygb", "gene_names_refseq": "3110001K20Rik; Cygb; HGb; Staap", "protein_names_uniprotkb": "Cytoglobin; 1.11.1.-; 1.14.12.-; 1.15.1.1; 1.7.-.-; Nitric oxygen dioxygenase; Nitrite reductase CYGB; Pseudoperoxidase CYGB; Superoxide dismutase CYGB", "protein_names_refseq": "cytoglobin isoform 1; histoglobin; nitric oxygen dioxygenase; nitrite reductase CYGB; pseudoperoxidase CYGB; stellate cell activation associated protein; superoxide dismutase CYGB", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); chronic pancreatitis (Disease Ontology:DOID:0051065); liver cirrhosis (Disease Ontology:DOID:5082); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:114886); (R-MMU-203615); (R-MMU-8981607)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11919282;12796507;14660570;15663964;19147491;28393874;32848054;33334890;34428180;34678516;34930834;36112670;37507081;37573836;37977965;40885482", "class_list": "", "function": "Differential expression of cytoglobin argues against a general respiratory function of this molecule, but rather indicates a connective tissue-specific function, [RefSeq, PubMed]; Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes., [RefSeq, PubMed]; Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:19147491, PubMed:28393874, PubMed:33334890, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:28393874, PubMed:33334890). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:19147491, PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (By similarity). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed:34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis., [RefSeq, PubMed]; The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators., [RefSeq, PubMed]; Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004096 catalase activity;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0019395 fatty acid oxidation;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9CX80-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX92-1", "uniprot_id": [ { "id": "CXE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX92", "type": "external" } ], "mass": 23831.0, "length": 205, "protein_name": "Gap junction epsilon-1 protein", "gene_name": "Gje1", "organism": "Mouse", "refseq_name": "gap junction epsilon-1 protein isoform 2", "refseq_ac": [ { "id": "NP_083998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083998", "type": "external" } ], "gene_names_uniprotkb": "Gje1; Cx23; Gjf1", "gene_names_refseq": "AEY12; Cx23; Cxnt; D230044M03Rik; Gje1; Gjf1; Gsfaey12", "protein_names_uniprotkb": "Gap junction epsilon-1 protein; Connexin-23; Cx23", "protein_names_refseq": "connexin 23; connexin t; gap junction epsilon-1 protein isoform 2; gap junction epsilon-1 protein; putative gap junction protein connexin Cx43.4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76743)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18385072;18849090;27038752", "class_list": "", "function": "Mediates calcium-independent ATP release, suggesting activity as a hemichannel (PubMed:18849090). Does not form functional gap junctions (PubMed:18849090). May play a non-essential role in eye lens development (PubMed:18385072, PubMed:27038752)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0000902 cell morphogenesis;GO:0035265 organ growth;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CX92-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYD3-1", "uniprot_id": [ { "id": "CRTAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYD3", "type": "external" } ], "mass": 46169.0, "length": 400, "protein_name": "Cartilage-associated protein", "gene_name": "Crtap", "organism": "Mouse", "refseq_name": "cartilage-associated protein precursor", "refseq_ac": [ { "id": "NP_064306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064306", "type": "external" } ], "gene_names_uniprotkb": "Crtap; Casp", "gene_names_refseq": "5730529N23Rik; CASP; Crtap; Leprel3; P3h5", "protein_names_uniprotkb": "Cartilage-associated protein", "protein_names_refseq": "cartilage-associated protein precursor", "tax_id": 10090, "disease": "osteogenesis imperfecta type 7 (Disease Ontology:DOID:0110337)", "pathway": " (mmu:56693); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10429950;17055431;25605945;30899004;31219806;32022592;32133710;34036937;34428180", "class_list": "", "function": "CRTAP mutations are associated with the clinical spectrum of recessive osteogenesis imperfecta, including the type II and VII forms, [RefSeq, PubMed]; Dental and craniofacial defects in the Crtap(-/-) mouse model of osteogenesis imperfecta type VII., [RefSeq, PubMed]; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues., [UniProtKB, PubMed]; Pressure-volume curves showed significant differences in lung volumes and in the shape of the curves between CrtapKO mice., [RefSeq, PubMed]; Tendon and motor phenotypes in the Crtap(-/-) mouse model of recessive osteogenesis imperfecta. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O88698;Q8C8C5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0007283 spermatogenesis;GO:0030199 collagen fibril organization;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CYD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D112-1", "uniprot_id": [ { "id": "SHLD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D112", "type": "external" } ], "mass": 22697.0, "length": 206, "protein_name": "Shieldin complex subunit 1", "gene_name": "Shld1", "organism": "Mouse", "refseq_name": "shieldin complex subunit 1", "refseq_ac": [ { "id": "NP_082913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082913", "type": "external" } ], "gene_names_uniprotkb": "Shld1; RINN3", "gene_names_refseq": "1110034G24Rik; Shld1", "protein_names_uniprotkb": "Shieldin complex subunit 1; RINN1-REV7-interacting novel NHEJ regulator 3", "protein_names_refseq": "RINN1-REV7-interacting novel NHEJ regulator 3; shieldin complex subunit 1; uncharacterized protein C20orf196 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73747)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;33857404", "class_list": "", "function": "Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres., [UniProtKB, UniProtKB]; The dystonia gene THAP1 controls DNA double-strand break repair choice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AW53", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0043247 telomere maintenance in response to DNA damage;GO:0006281 DNA repair;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D112-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3J9-1", "uniprot_id": [ { "id": "TASL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3J9", "type": "external" } ], "mass": 33057.0, "length": 298, "protein_name": "TLR adapter interacting with SLC15A4 on the lysosome", "gene_name": "Tasl", "organism": "Mouse", "refseq_name": "TLR adapter interacting with SLC15A4 on the lysosome", "refseq_ac": [ { "id": "NP_001157011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157011", "type": "external" } ], "gene_names_uniprotkb": "Tasl", "gene_names_refseq": "5430427O19Rik; Tasl", "protein_names_uniprotkb": "TLR adapter interacting with SLC15A4 on the lysosome", "protein_names_refseq": "TLR adapter interacting with SLC15A4 on the lysosome; uncharacterized protein CXorf21 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71398); (R-MMU-9860276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036020 endolysosome membrane", "go_biological_process": "GO:0034121 regulation of toll-like receptor signaling pathway;GO:0045087 innate immune response;GO:0034157 positive regulation of toll-like receptor 7 signaling pathway;GO:0045089 positive regulation of innate immune response;GO:0035751 regulation of lysosomal lumen pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D3J9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D454-1", "uniprot_id": [ { "id": "CX049_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D454", "type": "external" } ], "mass": 55249.0, "length": 513, "protein_name": "Uncharacterized protein CXorf49 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein CXorf49 homolog", "refseq_ac": [ { "id": "NP_081944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081944", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933412E24Rik", "protein_names_uniprotkb": "Uncharacterized protein CXorf49 homolog", "protein_names_refseq": "uncharacterized protein CXorf49 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71088)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;31219806;31616917", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D454-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAQ5-1", "uniprot_id": [ { "id": "SPMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAQ5", "type": "external" } ], "mass": 17772.0, "length": 155, "protein_name": "Sperm microtubule associated protein 1", "gene_name": "Spmap1", "organism": "Mouse", "refseq_name": "sperm microtubule associated protein 1", "refseq_ac": [ { "id": "NP_082432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082432", "type": "external" } ], "gene_names_uniprotkb": "Spmap1", "gene_names_refseq": "1700001P01Rik; Spmap1", "protein_names_uniprotkb": "Sperm microtubule associated protein 1", "protein_names_refseq": "sperm microtubule associated protein 1; uncharacterized protein C17orf98 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72215)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZQ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHH5-1", "uniprot_id": [ { "id": "CXL11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHH5", "type": "external" } ], "mass": 11266.0, "length": 100, "protein_name": "C-X-C motif chemokine 11", "gene_name": "Cxcl11", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 11 precursor", "refseq_ac": [ { "id": "NP_062367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062367", "type": "external" } ], "gene_names_uniprotkb": "Cxcl11; Scyb11", "gene_names_refseq": "Cxc11; Cxcl11; H174; I-tac; Ip9; Itac; Scyb11; Scyb9b; b-R1; betaR1", "protein_names_uniprotkb": "C-X-C motif chemokine 11; I-TAC; Interferon-inducible T-cell alpha chemoattractant; Small-inducible cytokine B11", "protein_names_refseq": "C-X-C motif chemokine 11 precursor; C-X-C motif chemokine 11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small-inducible cytokine B11", "tax_id": 10090, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); interstitial cystitis (Disease Ontology:DOID:13949); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:56066); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10828609;10843686;11500837;38070625", "class_list": "", "function": "Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity)., [UniProtKB]; Homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis, [RefSeq, PubMed]; Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM84-1", "uniprot_id": [ { "id": "CSTD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM84", "type": "external" } ], "mass": 16451.0, "length": 148, "protein_name": "Cystatin-D", "gene_name": "Cst5", "organism": "Mouse", "refseq_name": "cystatin-D precursor", "refseq_ac": [ { "id": "NP_067380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067380", "type": "external" } ], "gene_names_uniprotkb": "Cst5; Cst10; DD72", "gene_names_refseq": "Cst10; Cst5; DD72", "protein_names_uniprotkb": "Cystatin-D; Carminerin; Cystatin 10; Cystatin 5", "protein_names_refseq": "carminerin; cystatin 10 (chondrocytes); cystatin 5; cystatin-D precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:58214)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11856874;13679380;16680148", "class_list": "", "function": "Cst10 may play an important role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation, followed by apoptosis of chondrocytes, [RefSeq, PubMed]; Data show that cystatin 10 (carminerin) contributes to chondrocyte calcification during endochondral ossification under physiological and pathological conditions through the transcriptional inhibition of NPP1., [RefSeq, PubMed]; May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation (PubMed:13679380). Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification (PubMed:16680148). Possibly impairs the binding of a transcription factor to the ENPP1 promoter (PubMed:16680148). Unlike other cystatins, does not have thiol protease inhibitor activity (PubMed:16680148)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ART7", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031982 vesicle", "go_biological_process": "GO:0060349 bone morphogenesis;GO:0002062 chondrocyte differentiation;GO:0055074 calcium ion homeostasis;GO:0048469 cell maturation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JM84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMA7-1", "uniprot_id": [ { "id": "CP341_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMA7", "type": "external" } ], "mass": 57987.0, "length": 504, "protein_name": "Cytochrome P450 3A41", "gene_name": "Cyp3a41a; Cyp3a41b", "organism": "Mouse", "refseq_name": "cytochrome P450 3A41", "refseq_ac": [ { "id": "NP_001098629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098629", "type": "external" } ], "gene_names_uniprotkb": "Cyp3a41a; Cyp3a41b; Cyp3a41", "gene_names_refseq": "Cyp3a41b", "protein_names_uniprotkb": "Cytochrome P450 3A41; 1.14.14.1", "protein_names_refseq": "cytochrome P450 3A41", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:100041375); (mmu:53973); (R-MMU-211945); (R-MMU-211958); (R-MMU-211981); (R-MMU-5423646); (R-MMU-9027307); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "10775455;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQU5;E9QJT9", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0009617 response to bacterium;GO:0042573 retinoic acid metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JMA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUQ5-1", "uniprot_id": [ { "id": "CXL14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUQ5", "type": "external" } ], "mass": 11716.0, "length": 99, "protein_name": "C-X-C motif chemokine 14", "gene_name": "Cxcl14", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 14 precursor", "refseq_ac": [ { "id": "NP_062514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062514", "type": "external" } ], "gene_names_uniprotkb": "Cxcl14; Bmac; Kec; Ks1; Mip2g; Scyb14", "gene_names_refseq": "1110031L23Rik; 1200006I23Rik; BMAC; BRAK; Cxcl14; KS1; Kec; MIP-2g; MIP2gamma; NJAC; Scyb14; bolekine", "protein_names_uniprotkb": "C-X-C motif chemokine 14; B-cell and monocyte-activating chemokine; Chemokine BRAK; Kidney-expressed chemokine CXC; MIP-2G; Small-inducible cytokine B14", "protein_names_refseq": "B-cell and monocyte-activating chemokine; C-X-C motif chemokine 14 precursor; C-X-C motif chemokine 14; chemokine (C-X-C motif) ligand 14; chemokine BRAK; kidney-expressed chemokine CXC; musculus CXC chemokine MIP-2gamma; small inducible cytokine subfamily B (Cys-X-Cys), member 14; small-inducible cytokine B14", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:57266)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10049774;10784614;10946286;34428180;38821057", "class_list": "", "function": "Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells., [UniProtKB, PubMed]; FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548T5;Q91V02;Q9JHH7", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0031640 killing of cells of another organism;GO:0048839 inner ear development;GO:0045662 negative regulation of myoblast differentiation;GO:2000503 positive regulation of natural killer cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WUQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVL7-1", "uniprot_id": [ { "id": "CXL15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVL7", "type": "external" } ], "mass": 19091.0, "length": 167, "protein_name": "C-X-C motif chemokine 15", "gene_name": "Cxcl15", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 15 precursor", "refseq_ac": [ { "id": "NP_035469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035469", "type": "external" } ], "gene_names_uniprotkb": "Cxcl15; Scyb15", "gene_names_refseq": "Cxcl15; Il8; Scyb15; lungkine; weche", "protein_names_uniprotkb": "C-X-C motif chemokine 15; Lungkine; Small-inducible cytokine B15", "protein_names_refseq": "C-X-C motif chemokine 15 precursor; C-X-C motif chemokine 15; chemokine (C-X-C motif) ligand 15; interleukin 8; small inducible cytokine subfamily B, member 15; small-inducible cytokine B15", "tax_id": 10090, "disease": "", "pathway": " (mmu:20309)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10228029;11207292;21183079;30084848;37895168;38396325;39442986", "class_list": "", "function": "Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions., [UniProtKB, PubMed]; IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer., [RefSeq, PubMed]; Overexpression of Interleukin-8 Promotes the Progression of Fatty Liver to Nonalcoholic Steatohepatitis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; [CXCL8 generates an immunosuppressive microenvironment in colorectal cancer through induction of M2 macrophage infiltration and inhibition of CD8[+] T cell infiltration]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQ15", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51658-1", "uniprot_id": [ { "id": "DHB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51658", "type": "external" } ], "mass": 41836.0, "length": 381, "protein_name": "Estradiol 17-beta-dehydrogenase 2", "gene_name": "Hsd17b2", "organism": "Mouse", "refseq_name": "estradiol 17-beta-dehydrogenase 2 isoform 1", "refseq_ac": [ { "id": "NP_032316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032316", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b2; Edh17b2", "gene_names_refseq": "Hsd17b2", "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 2; 1.1.1.239; 1.1.1.62; 17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase type 2; Testosterone 17-beta-dehydrogenase", "protein_names_refseq": "17 HSD type 2; 17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase 2; 17-beta-hydroxysteroid dehydrogenase type 2; estradiol 17-beta-dehydrogenase 2 isoform 1; estradiol 17-beta-dehydrogenase 2; testosterone 17-beta-dehydrogenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:15486); (R-MMU-193144)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18048640;19576262;21750661;34428180;37453647;9224647", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity., [UniProtKB, UniProtKB]; HSD17B2 plays a role in the cellular organization of the mouse placenta., [RefSeq, PubMed]; These results demonstrate temporal and spatial regulation of androgen receptor and 17beta-HSD 2 during the sacculo-alveolar transition period of mouse lung development suggesting control of androgen action.[17beta HSD2], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08898", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001890 placenta development;GO:0032526 response to retinoic acid;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51658-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31428-1", "uniprot_id": [ { "id": "DPEP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31428", "type": "external" } ], "mass": 45722.0, "length": 410, "protein_name": "Dipeptidase 1", "gene_name": "Dpep1", "organism": "Mouse", "refseq_name": "dipeptidase 1 precursor", "refseq_ac": [ { "id": "NP_031902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031902", "type": "external" } ], "gene_names_uniprotkb": "Dpep1; Mbd1; Rdp", "gene_names_refseq": "DPEP-1; Dpep1; MBD", "protein_names_uniprotkb": "Dipeptidase 1; 3.4.13.19; 3.5.2.6; Beta-lactamase; DPEP-1; MBD-1; Membrane-bound dipeptidase 1; Microsomal dipeptidase; Renal dipeptidase", "protein_names_refseq": "MBD-1; beta-lactamase; dipeptidase 1 (renal); dipeptidase 1 precursor; membrane bound dipeptidase type II; membrane-bound dipeptidase 1; microsomal dipeptidase; renal dipeptidase", "tax_id": 10090, "disease": "hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (mmu:13479); (R-MMU-2142691); (R-MMU-5423646)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12738806;21750661;30084848;31442408;34428180;35108057;38626544;8507661;9560193", "class_list": "", "function": "Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis., [RefSeq, PubMed]; Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury., [RefSeq, PubMed]; Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:12738806, PubMed:31442408, PubMed:9560193). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:12738806, PubMed:9560193). Also possesses beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:12738806)., [UniProtKB, PubMed, PubMed, PubMed]; Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8522, "biomarker_type": "", "glycan_count": 22, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G5E824", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0008270 zinc ion binding;GO:0070573 metallodipeptidase activity;GO:0072341 modified amino acid binding;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0045177 apical part of cell", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0030336 negative regulation of cell migration;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P31428-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A9A2-1", "uniprot_id": [ { "id": "DMTA2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A9A2", "type": "external" } ], "mass": 52927.0, "length": 531, "protein_name": "Doublesex- and mab-3-related transcription factor A2", "gene_name": "Dmrta2", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor A2", "refseq_ac": [ { "id": "NP_758500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758500", "type": "external" } ], "gene_names_uniprotkb": "Dmrta2; Dmrt5", "gene_names_refseq": "Dmrt5; Dmrta2", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related transcription factor 5", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 5; doublesex- and mab-3-related transcription factor A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:242620)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12609607;21576465;25428506", "class_list": "", "function": "Dmrt5 is an important player in ventral mesencephalic neural fate specification, [RefSeq, PubMed]; May be involved in sexual development., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFF8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation;GO:0021796 cerebral cortex regionalization;GO:0035914 skeletal muscle cell differentiation;GO:0048665 neuron fate specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A9A2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X52-1", "uniprot_id": [ { "id": "DCXR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X52", "type": "external" } ], "mass": 25746.0, "length": 244, "protein_name": "L-xylulose reductase", "gene_name": "Dcxr", "organism": "Mouse", "refseq_name": "L-xylulose reductase isoform 1", "refseq_ac": [ { "id": "NP_080704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080704", "type": "external" } ], "gene_names_uniprotkb": "Dcxr", "gene_names_refseq": "0610038K04Rik; 1810027P18Rik; Dcxr; XR", "protein_names_uniprotkb": "L-xylulose reductase; 1.1.1.10; DCXR; Dicarbonyl/L-xylulose reductase; XR", "protein_names_refseq": "L-xylulose reductase isoform 1; diacetyl/L-xylulose reductase", "tax_id": 10090, "disease": "pentosuria (Disease Ontology:DOID:0111258)", "pathway": " (mmu:67880); (R-MMU-5661270)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11882650;15906319;16365515;21750661;37453647", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650)., [UniProtKB, PubMed]; DCXR might function in the metabolism of glucose or carbonyl compounds, and play a protective role in a kidney which is under hyperglycemic pressure., [RefSeq, PubMed]; Highly expressed in kidney and liver, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5L5;Q9D129;Q9D8W1", "ec_number_list": [ { "id": "1.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.10", "type": "external" } ], "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0016614 oxidoreductase activity, acting on CH-OH group of donors;GO:0042802 identical protein binding;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle;GO:0005902 microvillus", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0006739 NADP+ metabolic process;GO:0042732 D-xylose metabolic process;GO:0006006 glucose metabolic process;GO:2000379 positive regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91X52-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J79-1", "uniprot_id": [ { "id": "DDB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J79", "type": "external" } ], "mass": 48375.0, "length": 432, "protein_name": "DNA damage-binding protein 2", "gene_name": "Ddb2", "organism": "Mouse", "refseq_name": "DNA damage-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_082395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082395", "type": "external" } ], "gene_names_uniprotkb": "Ddb2", "gene_names_refseq": "2610043A19Rik; Ddb2", "protein_names_uniprotkb": "DNA damage-binding protein 2; Damage-specific DNA-binding protein 2", "protein_names_refseq": "DNA damage-binding protein 2 isoform 1; DNA damage-binding protein 2", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group E (Disease Ontology:DOID:0110846)", "pathway": " (mmu:107986); (R-MMU-5689880); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-8951664)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10713455;11971958;12107171;14769931;15558025;17468495;17635991;21750661;23319653;23610444;27203177;29021137;33937266", "class_list": "", "function": "DDB2 plays a critical role in suppressing development of colon cancer at early stage by regulating Wnt signaling. Mice genetically deficient in DDB2 exhibited increased susceptibility to colon tumor development in a manner associated with higher abundance of the Wnt receptor-expressing cells and greater activation of the downstream Wnt pathway., [RefSeq, PubMed]; DDB2-deficient mice developed spontaneous malignant tumors at a high rate between the ages of 20 and 25 months., [RefSeq, PubMed]; Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1)collaborates with DNA-binding protein 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (GG-NER)., [RefSeq, PubMed]; Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:33937266). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (By similarity). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (By similarity). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Results demonstrate that DDB2 is well conserved between humans and mice and functions as a tumor suppressor, at least in part, by controlling p53-mediated apoptosis after UV-irradiation, [RefSeq, PubMed]; Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer., [RefSeq, PubMed]; These results demonstrate direct activation of the human DDB2 gene by p53. The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 binding and transcriptional activation., [RefSeq, PubMed]; UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030054 cell junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99J79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35654-1", "uniprot_id": [ { "id": "DPOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35654", "type": "external" } ], "mass": 51355.0, "length": 469, "protein_name": "DNA polymerase delta subunit 2", "gene_name": "Pold2", "organism": "Mouse", "refseq_name": "DNA polymerase delta subunit 2", "refseq_ac": [ { "id": "NP_032920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032920", "type": "external" } ], "gene_names_uniprotkb": "Pold2", "gene_names_refseq": "50kDa; Pold2; p50; po1D2", "protein_names_uniprotkb": "DNA polymerase delta subunit 2; DNA polymerase delta subunit p50", "protein_names_refseq": "DNA polymerase delta subunit 2; DNA polymerase delta subunit p50", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18972); (R-MMU-110314); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174437); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 19, "publication_count": 13, "publication_id_list": "12522211;21750661;22824807;22872234;25428506;25605945;29187734;30059200;31599954;32782141;36528861;36852467;9286699", "class_list": "", "function": "A direct interaction between Pold2 and PIAS2 was confirmed by direct yeast two-hybrid., [RefSeq, PubMed]; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7., [UniProtKB, UniProtKB]; Early embryonic lethality of mice lacking POLD2., [RefSeq, PubMed]; The association of PDIP38 with pol delta was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 pull-down and coimmunoprecipitation experiments., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q99J61", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005654 nucleoplasm;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35654-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z61-1", "uniprot_id": [ { "id": "DIRA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Z61", "type": "external" } ], "mass": 22265.0, "length": 198, "protein_name": "GTP-binding protein Di-Ras1", "gene_name": "Diras1", "organism": "Mouse", "refseq_name": "GTP-binding protein Di-Ras1", "refseq_ac": [ { "id": "NP_660252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660252", "type": "external" } ], "gene_names_uniprotkb": "Diras1; Gbts1", "gene_names_refseq": "Di-Ras1; Diras1; Gbts1; RIG", "protein_names_uniprotkb": "GTP-binding protein Di-Ras1; Distinct subgroup of the Ras family member 1; Small GTP-binding tumor suppressor 1", "protein_names_refseq": "GTP-binding protein Di-Ras1; distinct subgroup of the Ras family member 1; small GTP-binding tumor suppressor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208666)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Displays low GTPase activity and exists predominantly in the GTP-bound form., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91Z61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFQ6-1", "uniprot_id": [ { "id": "DIRC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFQ6", "type": "external" } ], "mass": 51909.0, "length": 478, "protein_name": "Solute carrier family 49 member 4", "gene_name": "Slc49a4", "organism": "Mouse", "refseq_name": "solute carrier family 49 member 4", "refseq_ac": [ { "id": "NP_705778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705778", "type": "external" } ], "gene_names_uniprotkb": "Slc49a4; Dirc2", "gene_names_refseq": "Dirc2; RCC4; Slc49a4", "protein_names_uniprotkb": "Solute carrier family 49 member 4; Disrupted in renal carcinoma protein 2 homolog", "protein_names_refseq": "disrupted in renal carcinoma 2; disrupted in renal carcinoma protein 2 homolog; solute carrier family 49 member 4", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:224132)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Mediates H(+)-dependent pyridoxine transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0031923 pyridoxine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BFQ6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHZ5-1", "uniprot_id": [ { "id": "DDT4L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHZ5", "type": "external" } ], "mass": 21581.0, "length": 193, "protein_name": "DNA damage-inducible transcript 4-like protein", "gene_name": "Ddit4l", "organism": "Mouse", "refseq_name": "DNA damage-inducible transcript 4-like protein", "refseq_ac": [ { "id": "NP_084419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084419", "type": "external" } ], "gene_names_uniprotkb": "Ddit4l; Rtp801l; Smhs1", "gene_names_refseq": "1700037B15Rik; 1700108M02Rik; Ddit4l; REDD2; RTP801L; Smhs1", "protein_names_uniprotkb": "DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; Soleus muscle atrophied after hindlimb suspension protein 1", "protein_names_refseq": "DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; skeletal muscle hindlimb suspension 1; soleus muscle atrophied after hindlimb suspension protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73284)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11596118;11884613;15607738;15632201;21750661", "class_list": "", "function": "Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1., [UniProtKB, UniProtKB, UniProtKB]; RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions, [RefSeq, PubMed]; SMHS1 was found to be expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to muscle energy metabolism phenotypes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Z7;Q8VD49;Q9CQV2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9R1-1", "uniprot_id": [ { "id": "DDX51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9R1", "type": "external" } ], "mass": 70368.0, "length": 639, "protein_name": "ATP-dependent RNA helicase DDX51", "gene_name": "Ddx51", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX51", "refseq_ac": [ { "id": "NP_081432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081432", "type": "external" } ], "gene_names_uniprotkb": "Ddx51", "gene_names_refseq": "2310061O04Rik; Ddx51", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX51; 3.6.4.13; DEAD box protein 51", "protein_names_refseq": "ATP-dependent RNA helicase DDX51; DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; DEAD box protein 51", "tax_id": 10090, "disease": "", "pathway": " (mmu:69663)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20404093;21183079;21750661;31219806;34428180", "class_list": "", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits., [UniProtKB]; The mammalian DEAD box helicase family member Ddx51 is identified as a novel ribosome synthesis factor and an interacting partner of the nucleolar GTP-binding protein Nog1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7M2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P9R1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VY9-1", "uniprot_id": [ { "id": "DHX33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VY9", "type": "external" } ], "mass": 78347.0, "length": 698, "protein_name": "ATP-dependent RNA helicase DHX33", "gene_name": "Dhx33", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DHX33", "refseq_ac": [ { "id": "NP_848144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848144", "type": "external" } ], "gene_names_uniprotkb": "Dhx33", "gene_names_refseq": "3110057P17Rik; 9430096J02Rik; Ddx33; Dhx33", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX33; 3.6.4.13; DEAH box protein 33", "protein_names_refseq": "ATP-dependent RNA helicase DHX33; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33; DEAH (Asp-Glu-Ala-His) box polypeptide 33; DEAH box protein 33; putative ATP-dependent RNA helicase DHX33", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:216877)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20485683;21750661;21930779;23401854;24037184;26100019;29273634;30084848;32617965;32767810;34428180;36631557", "class_list": "", "function": "Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation., [RefSeq, PubMed]; Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes., [RefSeq, PubMed]; Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (By similarity). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (PubMed:24037184)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Results directly implicate DHX33 as a crucial player in establishing rRNA synthesis rates in the face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals, [RefSeq, PubMed]; Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS50", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0072559 NLRP3 inflammasome complex", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0006413 translational initiation;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0032481 positive regulation of type I interferon production;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80VY9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88736-1", "uniprot_id": [ { "id": "DHB7_MOUSE", "url": "https://www.uniprot.org/uniprot/O88736", "type": "external" } ], "mass": 37317.0, "length": 334, "protein_name": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7", "gene_name": "Hsd17b7", "organism": "Mouse", "refseq_name": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 2", "refseq_ac": [ { "id": "NP_034606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034606", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b7; 17hsd7", "gene_names_refseq": "ERG27; Hsd17b7", "protein_names_uniprotkb": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 1.1.1.210; 1.1.1.270; 1.1.1.62; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase; Estradiol 17-beta-dehydrogenase 7", "protein_names_refseq": "17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform 2; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; dihydrotestosterone oxidoreductase; estradiol 17-beta-dehydrogenase 7", "tax_id": 10090, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); steroid inherited metabolic disorder (Disease Ontology:DOID:1701)", "pathway": " (mmu:15490); (R-MMU-6807047); (R-MMU-6807062)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12732193;12829805;18669642;20659585;34428180;9658408", "class_list": "", "function": "Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12732193, PubMed:9658408). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol (PubMed:12732193). Does not metabolize progesterone (PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5C9;Q921L1", "ec_number_list": [ { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" } ], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity;GO:0047024 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006695 cholesterol biosynthetic process;GO:0007420 brain development;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88736-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DOY1-1", "uniprot_id": [ { "id": "DNM3C_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DOY1", "type": "external" } ], "mass": 82921.0, "length": 740, "protein_name": "DNA (cytosine-5)-methyltransferase 3C", "gene_name": "Dnmt3c", "organism": "Mouse", "refseq_name": "DNA methyltransferase 3C", "refseq_ac": [ { "id": "NP_001411976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411976", "type": "external" } ], "gene_names_uniprotkb": "Dnmt3c; Gm14490", "gene_names_refseq": "Dnmt3b-ps1; Dnmt3c-ps; Dnmt3c; Gm14490", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3C; 2.1.1.37; Dnmt3c", "protein_names_refseq": "DNA methyltransferase 3B, pseudogene 1; DNA methyltransferase 3C, pseudogene; DNA methyltransferase 3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:668932)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "27856912;28854222;32077945;32674113;38359823;38755427;39098534", "class_list": "", "function": "DNA methyltransferase that specifically methylates the promoters of evolutionarily young retrotransposons in the male germline (PubMed:27856912, PubMed:28854222, PubMed:38359823, PubMed:39098534). De novo methylation and subsequent repression of transposable elements prevents their mobilization, which is essential for germline integrity (PubMed:27856912, PubMed:28854222, PubMed:38359823). Compared to Dnmt3a and Dnmt3b, shows lower DNA methyltransferase efficiency (PubMed:39098534)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Dnmt3c is required for DNA methylation and transposon repression in the mouse male germline. Publication Status: Online-Only, [RefSeq, PubMed]; Dynamic Evolution of De Novo DNA Methyltransferases in Rodent and Primate Genomes., [RefSeq, PubMed]; Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286YDX7", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0032259 methylation;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0DOY1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51661-1", "uniprot_id": [ { "id": "DHI2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51661", "type": "external" } ], "mass": 42187.0, "length": 386, "protein_name": "11-beta-hydroxysteroid dehydrogenase type 2", "gene_name": "Hsd11b2", "organism": "Mouse", "refseq_name": "11-beta-hydroxysteroid dehydrogenase type 2", "refseq_ac": [ { "id": "NP_032315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032315", "type": "external" } ], "gene_names_uniprotkb": "Hsd11b2; Hsd11k", "gene_names_refseq": "11HSD2; Hsd11b2", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase type 2; 1.1.1.-; 11-DH2; 11-beta-HSD2; Corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase", "protein_names_refseq": "11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); apparent mineralocorticoid excess syndrome (Disease Ontology:DOID:4367); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); inherited metabolic disorder (Disease Ontology:DOID:655); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15484); (R-MMU-194002); (R-MMU-9757110)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1312193;22796344;30340023;30902677;31600723;34428180;7664690", "class_list": "", "function": "Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (PubMed:22796344, PubMed:30902677, PubMed:31600723). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:7664690). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (PubMed:31600723). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (PubMed:22796344). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (PubMed:30340023)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WK3", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0005496 steroid binding;GO:0070523 11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032094 response to food;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51661-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q18PE0-1", "uniprot_id": [ { "id": "DOK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q18PE0", "type": "external" } ], "mass": 53177.0, "length": 504, "protein_name": "Protein Dok-7", "gene_name": "Dok7", "organism": "Mouse", "refseq_name": "protein Dok-7 isoform 2", "refseq_ac": [ { "id": "NP_001335203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335203", "type": "external" } ], "gene_names_uniprotkb": "Dok7", "gene_names_refseq": "A930013K19Rik; Dok-7; Dok7; EF-12; Oit5", "protein_names_uniprotkb": "Protein Dok-7; Downstream of tyrosine kinase 7", "protein_names_refseq": "downstream of tyrosine kinase 7; oncoprotein induced transcript 5; protein Dok-7 isoform 2; protein Dok-7", "tax_id": 10090, "disease": "congenital myasthenic syndrome 10 (Disease Ontology:DOID:0110668); fetal akinesia deformation sequence syndrome 3 (Disease Ontology:DOID:0111376)", "pathway": " (mmu:231134)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16794080;18165682;20603078;21750661;36464749;38245592", "class_list": "", "function": "DOK7 Promotes NMJ Regeneration After Nerve Injury., [RefSeq, PubMed]; Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK, [RefSeq, PubMed]; Peroxisome proliferator-activated receptor gamma coactivator 1alpha regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation. Publication Status: Online-Only, [RefSeq, PubMed]; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK., [UniProtKB, PubMed, PubMed]; The COOH-terminal NES and Src homology 2 target motifs play key roles in Dok-7/MuSK signaling for neuromuscular synaptogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCZ6;Q5FW70;Q8C8U7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031594 neuromuscular junction;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007528 neuromuscular junction development;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0035022 positive regulation of Rac protein signal transduction;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q18PE0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2MHE5-1", "uniprot_id": [ { "id": "DOK6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2MHE5", "type": "external" } ], "mass": 38287.0, "length": 331, "protein_name": "Docking protein 6", "gene_name": "Dok6", "organism": "Mouse", "refseq_name": "docking protein 6", "refseq_ac": [ { "id": "NP_001034262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034262", "type": "external" } ], "gene_names_uniprotkb": "Dok6", "gene_names_refseq": "Dok-6; Dok6", "protein_names_uniprotkb": "Docking protein 6; Downstream of tyrosine kinase 6", "protein_names_refseq": "docking protein 6; downstream of tyrosine kinase 6; downstream of tyrosine kinases 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:623279); (R-MMU-8853659)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20565848;38351062", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity)., [UniProtKB]; Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Dok6 selectively binds to the NPQY motif of TrkC through its phosphotyrosine-binding (PTB) domain in a kinase activity-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSP9", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2MHE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TNW5-1", "uniprot_id": [ { "id": "MUCL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TNW5", "type": "external" } ], "mass": 54310.0, "length": 500, "protein_name": "Mucin-like protein 3", "gene_name": "Mucl3", "organism": "Mouse", "refseq_name": "mucin-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001028538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028538", "type": "external" } ], "gene_names_uniprotkb": "Mucl3; Dpcr1; Gm630", "gene_names_refseq": "Dpcr1; Gm630; Mucl3", "protein_names_uniprotkb": "Mucin-like protein 3; Diffuse panbronchiolitis critical region protein 1 homolog", "protein_names_refseq": "diffuse panbronchiolitis critical region 1; diffuse panbronchiolitis critical region protein 1 homolog; mucin-like protein 3 precursor; mucin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:268949)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "May modulate NF-kappaB signaling and play a role in cell growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TNW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60997-1", "uniprot_id": [ { "id": "DMBT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60997", "type": "external" } ], "mass": 226815.0, "length": 2085, "protein_name": "Scavenger receptor cysteine-rich domain-containing protein DMBT1", "gene_name": "Dmbt1", "organism": "Mouse", "refseq_name": "scavenger receptor cysteine-rich domain-containing protein DMBT1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001334561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334561", "type": "external" } ], "gene_names_uniprotkb": "Dmbt1; Crpd", "gene_names_refseq": "CRP-[a]; CRP-[b]; CRP; Crpd; DBMT1; Dmbt1; gp300; p80", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich domain-containing protein DMBT1; Apactin; CRP-ductin; Deleted in malignant brain tumors 1 protein; Glycoprotein 300; Hensin; Mucin-like glycoprotein; Muclin; Vomeroglandin; gp300; p80", "protein_names_refseq": "apactin; crp-ductin; deleted in malignant brain tumors 1 protein; deleted in malignant brain tumors 1 pseudogene; ebnerin; glycoprotein 300; hensin; mucin-like glycoprotein; muclin; scavenger receptor cysteine-rich domain-containing protein DMBT1 isoform 1 precursor; scavenger receptor cysteine-rich domain-containing protein DMBT1; vomeroglandin", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:12945); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10679193;11152281;12082154;12884308;15146979;15292166;15452149;15987769;17983803;18202109;21750661;28011936;30084848;34282203;34323417;34428180;35820727;37232026;7537458;7876332;8543783;8742698;9247472;9688648", "class_list": "", "function": "CRP-ductin (also known as Muclin) is upregulated in the pancreas and gastrointestinal tract of CFTR knockout mice. This sulfated glycoprotein may be a protective molecule upregulated by inflammation., [RefSeq, PubMed]; DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model., [RefSeq, PubMed]; Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice., [RefSeq, PubMed]; May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 28, "predicted_n_glycosites": 21, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 28, "binding_glycan_count": 0, "secondary_ac_list": "Q80YC6;Q9JMJ9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005044 scavenger receptor activity;GO:1904399 heparan sulfate binding;GO:0001530 lipopolysaccharide binding;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0030658 transport vesicle membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q60997-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64237-1", "uniprot_id": [ { "id": "DOPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64237", "type": "external" } ], "mass": 70314.0, "length": 622, "protein_name": "Dopamine beta-hydroxylase", "gene_name": "Dbh", "organism": "Mouse", "refseq_name": "dopamine beta-hydroxylase", "refseq_ac": [ { "id": "NP_620392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620392", "type": "external" } ], "gene_names_uniprotkb": "Dbh", "gene_names_refseq": "Dbh", "protein_names_uniprotkb": "Dopamine beta-hydroxylase; 1.14.17.1; Dopamine beta-monooxygenase", "protein_names_refseq": "dopamine beta-hydroxylase; dopamine beta-monooxygenase", "tax_id": 10090, "disease": "dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); migraine with aura (Disease Ontology:DOID:10024); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:13166); (R-MMU-209905)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12616489;1280432;27069933;27148966;30899004;7715704;7961964", "class_list": "", "function": "Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1U4", "ec_number_list": [ { "id": "1.14.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.17.1", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0031418 L-ascorbic acid binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0030425 dendrite;GO:0034774 secretory granule lumen", "go_biological_process": "GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008306 associative learning;GO:0008542 visual learning;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64237-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZQ2-1", "uniprot_id": [ { "id": "DDX31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZQ2", "type": "external" } ], "mass": 76913.0, "length": 687, "protein_name": "ATP-dependent DNA helicase DDX31", "gene_name": "Ddx31", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase DDX31", "refseq_ac": [ { "id": "NP_001028466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028466", "type": "external" } ], "gene_names_uniprotkb": "Ddx31", "gene_names_refseq": "5830444G11Rik; Ddx31; Gm997", "protein_names_uniprotkb": "ATP-dependent DNA helicase DDX31; 3.6.4.13; 5.6.2.-; DEAD box protein 31; Probable ATP-dependent RNA helicase DDX31", "protein_names_refseq": "ATP-dependent DNA helicase DDX31; DEAD box protein 31; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31; probable ATP-dependent RNA helicase DDX31", "tax_id": 10090, "disease": "", "pathway": " (mmu:227674)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;30779550", "class_list": "", "function": "May have DNA helicase activity and RNA helicase activity. Probably have ssDNA and RNA dependent ATPase activity (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIT3;A3KMM3;Q3TLT4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NZQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDK8-1", "uniprot_id": [ { "id": "DTX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDK8", "type": "external" } ], "mass": 66821.0, "length": 616, "protein_name": "E3 ubiquitin-protein ligase DTX4", "gene_name": "Dtx4", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DTX4 isoform 1", "refseq_ac": [ { "id": "NP_766030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766030", "type": "external" } ], "gene_names_uniprotkb": "Dtx4", "gene_names_refseq": "D930042H13; Dtx4; RNF155", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX4; 2.3.2.27; Deltex4; Protein deltex-4; RING-type E3 ubiquitin transferase DTX4", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX4 isoform 1; E3 ubiquitin-protein ligase DTX4; RING-type E3 ubiquitin transferase DTX4; deltex 4 homolog; deltex4; protein deltex-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:207521); (R-MMU-2122948); (R-MMU-3134975); (R-MMU-3270619)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15684394;16923970;28842252", "class_list": "", "function": "Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations., [UniProtKB, PubMed]; The results indicate that DTX4 stable knockdown inhibits adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha and PPARgamma, arresting mitotic clonal expansion and regulating Wnt signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IS30;Q8BID3", "ec_number_list": [ { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0045087 innate immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PDK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGC1-1", "uniprot_id": [ { "id": "DHX29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGC1", "type": "external" } ], "mass": 153975.0, "length": 1365, "protein_name": "ATP-dependent RNA helicase DHX29", "gene_name": "Dhx29", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase Dhx29", "refseq_ac": [ { "id": "NP_766182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766182", "type": "external" } ], "gene_names_uniprotkb": "Dhx29", "gene_names_refseq": "3732415M03; Ddxx; Dhx29; E130202M19Rik", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX29; 3.6.4.13; DEAH box protein 29", "protein_names_refseq": "ATP-dependent RNA helicase Dhx29; DEAH (Asp-Glu-Ala-His) box polypeptide 29; DEAH box protein 29; nucleic acid helicase DDXx", "tax_id": 10090, "disease": "", "pathway": " (mmu:218629)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30084848;34428180;34678516;35820727", "class_list": "", "function": "ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQJ4;Q8BT01;Q8C9B7;Q8C9H9", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043024 ribosomal small subunit binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016282 eukaryotic 43S preinitiation complex;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0001731 formation of translation preinitiation complex;GO:0042255 ribosome assembly;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PGC1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VY05-1", "uniprot_id": [ { "id": "DND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VY05", "type": "external" } ], "mass": 39076.0, "length": 352, "protein_name": "Dead end protein homolog 1", "gene_name": "Dnd1", "organism": "Mouse", "refseq_name": "dead end protein homolog 1", "refseq_ac": [ { "id": "NP_775559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775559", "type": "external" } ], "gene_names_uniprotkb": "Dnd1; Rbms4; Ter", "gene_names_refseq": "Dnd1; RBMS4; Ter", "protein_names_uniprotkb": "Dead end protein homolog 1; RNA-binding motif, single-stranded-interacting protein 4", "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 4; dead end homolog 1; dead end protein homolog 1; teratoma", "tax_id": 10090, "disease": "teratocarcinoma (Disease Ontology:DOID:3305)", "pathway": " (mmu:213236)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12932328;15902260;17291453;18509452;24129315;31599954;37076592", "class_list": "", "function": "Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testes. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFK7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0007281 germ cell development;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6VY05-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSF0-1", "uniprot_id": [ { "id": "DSG1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSF0", "type": "external" } ], "mass": 100516.0, "length": 911, "protein_name": "Desmoglein-1-gamma", "gene_name": "Dsg1c", "organism": "Mouse", "refseq_name": "desmoglein-1-gamma preproprotein", "refseq_ac": [ { "id": "NP_859008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859008", "type": "external" } ], "gene_names_uniprotkb": "Dsg1c; Dsg6", "gene_names_refseq": "Dsg1c; Dsg1gamma; Dsg6; dsg1g", "protein_names_uniprotkb": "Desmoglein-1-gamma; Desmoglein-6; Dsg1-gamma", "protein_names_refseq": "desmoglein 6; desmoglein-1-gamma preproprotein", "tax_id": 10090, "disease": "keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108)", "pathway": " (mmu:211924)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12631243;12787123;16170054;24220297;30660666;34428180", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (PubMed:30660666). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (PubMed:30660666)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development., [RefSeq, PubMed]; Expressed in brain, skeletal muscle, and liver, among other tissues. Similar to Dsg2 in its tissue distribution. Orthologous Dsg1 gamma was not found in human genome, suggesting desmosomal cadherin gene cluster contracted during mammalian evolution., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ61", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050821 protein stabilization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TSF0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VJ3-1", "uniprot_id": [ { "id": "DNPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VJ3", "type": "external" } ], "mass": 18977.0, "length": 173, "protein_name": "5-hydroxymethyl-dUMP N-hydrolase", "gene_name": "Dnph1", "organism": "Mouse", "refseq_name": "5-hydroxymethyl-dUMP N-hydrolase", "refseq_ac": [ { "id": "NP_997044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997044", "type": "external" } ], "gene_names_uniprotkb": "Dnph1", "gene_names_refseq": "Dnph1; Rcl", "protein_names_uniprotkb": "5-hydroxymethyl-dUMP N-hydrolase; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; 3.2.2.-", "protein_names_refseq": "5-hydroxymethyl-dUMP N-hydrolase; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase; putative c-Myc-responsive", "tax_id": 10090, "disease": "", "pathway": " (mmu:381101); (R-MMU-74259)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;31219806", "class_list": "", "function": "Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9Y7", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030855 epithelial cell differentiation;GO:0000255 allantoin metabolic process;GO:0009159 deoxyribonucleoside monophosphate catabolic process;GO:0046055 dGMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTF7-1", "uniprot_id": [ { "id": "DNLI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTF7", "type": "external" } ], "mass": 104120.0, "length": 911, "protein_name": "DNA ligase 4", "gene_name": "Lig4", "organism": "Mouse", "refseq_name": "DNA ligase 4", "refseq_ac": [ { "id": "NP_795927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795927", "type": "external" } ], "gene_names_uniprotkb": "Lig4", "gene_names_refseq": "5830471N16Rik; Lig4; tiny", "protein_names_uniprotkb": "DNA ligase 4; 6.5.1.1; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4", "protein_names_refseq": "DNA ligase 4; DNA ligase IV; polydeoxyribonucleotide synthase [ATP] 4", "tax_id": 10090, "disease": "DNA ligase IV deficiency (Disease Ontology:DOID:0060021); prostate cancer (Disease Ontology:DOID:10283); pancreatic cancer (Disease Ontology:DOID:1793); high grade glioma (Disease Ontology:DOID:3070); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:319583); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "30084848;30779550;31541646;37871849;9889105", "class_list": "", "function": "DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. LIG4 regulates nuclear localization of XRCC4., [UniProtKB, UniProtKB]; Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics., [RefSeq, PubMed]; Hypomorphic Lig4 mutation Promotes nonprogressive microcephaly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UWC4;Q3UG76", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003909 DNA ligase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0002328 pro-B cell differentiation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:2001252 positive regulation of chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BTF7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYH0-1", "uniprot_id": [ { "id": "DRGX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYH0", "type": "external" } ], "mass": 28717.0, "length": 263, "protein_name": "Dorsal root ganglia homeobox protein", "gene_name": "Drgx", "organism": "Mouse", "refseq_name": "dorsal root ganglia homeobox protein isoform 2", "refseq_ac": [ { "id": "NP_001001796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001796", "type": "external" } ], "gene_names_uniprotkb": "Drgx; Drg11; Prrxl1", "gene_names_refseq": "Drg11; Drgx; Prrxl1", "protein_names_uniprotkb": "Dorsal root ganglia homeobox protein; Dorsal root ganglion 11; Homeobox protein DRG11; Paired-related homeobox protein-like 1", "protein_names_refseq": "dorsal root ganglia homeobox protein isoform 2; dorsal root ganglia homeobox protein; dorsal root ganglion 11; homeobox protein DRG11; paired homeodomain protein DRG11; paired related homeobox protein-like 1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:107751)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11498051;12917357;14985445;15099678;19598127;24564673;28049756", "class_list": "", "function": "Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires Drg11., [RefSeq, PubMed]; The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTS1;B2ZIF3;B2ZIF4;Q8K3F8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009593 detection of chemical stimulus;GO:0021516 dorsal spinal cord development;GO:0050954 sensory perception of mechanical stimulus;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BYH0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C255-1", "uniprot_id": [ { "id": "DPEP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C255", "type": "external" } ], "mass": 52664.0, "length": 478, "protein_name": "Dipeptidase 2", "gene_name": "Dpep2", "organism": "Mouse", "refseq_name": "dipeptidase 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001288133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288133", "type": "external" } ], "gene_names_uniprotkb": "Dpep2; Mbd2", "gene_names_refseq": "Dpep2; F630103D06Rik; MBD-2", "protein_names_uniprotkb": "Dipeptidase 2; 3.4.13.19; MBD-2; Membrane-bound dipeptidase 2", "protein_names_refseq": "dipeptidase 2 isoform 1 precursor; putative membrane-bound dipeptidase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319446); (R-MMU-2142691); (R-MMU-5423646)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12738806;21750661;30899700;34428180", "class_list": "", "function": "Cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3, [RefSeq, PubMed]; Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Hydrolyzes cystinyl-bis-glycine (By similarity)., [UniProtKB, PubMed, UniProtKB]; Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappa-B inflammatory signaling pathway., [UniProtKB, PubMed]; Taken together, this study revealed that Dpep2 could protect against Coxsackievirus B3-induced viral myocarditis by acting as a suppressor of macrophage inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAV9;Q3TBF7;Q3TBK3;Q3TBM9;Q7TQ53", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008238 exopeptidase activity;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006691 leukotriene metabolic process;GO:1901749 leukotriene D4 catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C255-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHS2-1", "uniprot_id": [ { "id": "DJC22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHS2", "type": "external" } ], "mass": 37942.0, "length": 339, "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "Dnajc22", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 22", "refseq_ac": [ { "id": "NP_789805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789805", "type": "external" } ], "gene_names_uniprotkb": "Dnajc22", "gene_names_refseq": "2810451A06Rik; Dnajc22", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 22", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 3; DnaJ (Hsp40) homolog, subfamily C, member 22; dnaJ homolog subfamily C member 22; heat shock protein, DNAJ-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72778)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;34428180", "class_list": "", "function": "May function as a co-chaperone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CHS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHS7-1", "uniprot_id": [ { "id": "DRS7C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHS7", "type": "external" } ], "mass": 34468.0, "length": 311, "protein_name": "Dehydrogenase/reductase SDR family member 7C", "gene_name": "Dhrs7c", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 7C precursor", "refseq_ac": [ { "id": "NP_001013031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013031", "type": "external" } ], "gene_names_uniprotkb": "Dhrs7c; Sdr32c2; Srp-35", "gene_names_refseq": "1110001P11Rik; Dhrs7c; SRP-35", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 7C; 1.1.1.105; Protein SDR32C2; Protein SRP-35; Sarcoplasmic reticulum protein of 35 kDa; Short-chain dehydrogenase/reductase family 32C member 2", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7C; dehydrogenase/reductase SDR family member 7C precursor; sarcoplasmic reticulum protein of 35 kDa; short-chain dehydrogenase/reductase family 32C member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68460)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21995425;22143674;27806939;29330505;39927985", "class_list": "", "function": "NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal (PubMed:21995425). Plays a role in the regulation of cardiac and skeletal muscle metabolic functions (Probable) (PubMed:21995425, PubMed:27806939, PubMed:29330505). Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal (PubMed:21995425). Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes (PubMed:27806939). Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid (PubMed:29330505)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Skeletal muscle SRP-35 is involved in the generation of all-trans-retinaldehyde and may play an important role in the generation of intracellular signals linking Ca2+ release (i.e. muscle activity) to metabolism., [RefSeq, PubMed]; Study demonstrates that the skeletal muscle protein SRP-35, a retinol dehydrogenase, is directly involved in skeletal muscle metabolism, since its over-expression results in higher glucose uptake and increased glycogen storage. In addition, SRP-35 over-expression improves muscle performance in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Taken together, our findings suggested that DHRS7C maintains intracellular Ca(2+) homeostasis involving the ER/SR and that functional loss of DHRS7C leads to Ca(2+) overload in the cytosol and ER/SR, resulting in enlarged cellular morphology via calpain activation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATJ2", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0014801 longitudinal sarcoplasmic reticulum", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CHS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIG0-1", "uniprot_id": [ { "id": "DEP1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIG0", "type": "external" } ], "mass": 92201.0, "length": 804, "protein_name": "DEP domain-containing protein 1A", "gene_name": "Depdc1a", "organism": "Mouse", "refseq_name": "DEP domain-containing protein 1A isoform 1", "refseq_ac": [ { "id": "NP_001165563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165563", "type": "external" } ], "gene_names_uniprotkb": "Depdc1a", "gene_names_refseq": "5830484J08Rik; Depdc1a; Depdc1", "protein_names_uniprotkb": "DEP domain-containing protein 1A", "protein_names_refseq": "DEP domain-containing protein 1A isoform 1; DEP domain-containing protein 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:76131)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18299400;21750661;21952136;25605945;31219806;34428180", "class_list": "", "function": "May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHF1;Q99JN3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2I6-1", "uniprot_id": [ { "id": "DEFB9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2I6", "type": "external" } ], "mass": 7682.0, "length": 67, "protein_name": "Beta-defensin 9", "gene_name": "Defb9", "organism": "Mouse", "refseq_name": "beta-defensin 9 precursor", "refseq_ac": [ { "id": "NP_631965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631965", "type": "external" } ], "gene_names_uniprotkb": "Defb9", "gene_names_refseq": "BD-9; Defb9", "protein_names_uniprotkb": "Beta-defensin 9; BD-9; Defensin, beta 9; mBD-9", "protein_names_refseq": "beta-defensin 9 precursor; beta-defensin 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:246079)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12644567", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Y3-1", "uniprot_id": [ { "id": "DOLK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Y3", "type": "external" } ], "mass": 59145.0, "length": 534, "protein_name": "Dolichol kinase", "gene_name": "Dolk", "organism": "Mouse", "refseq_name": "dolichol kinase", "refseq_ac": [ { "id": "NP_808316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808316", "type": "external" } ], "gene_names_uniprotkb": "Dolk; Tmem15", "gene_names_refseq": "Dolk; Tmem15; mKIAA1094", "protein_names_uniprotkb": "Dolichol kinase; 2.7.1.108; Transmembrane protein 15", "protein_names_refseq": "dolichol kinase; transmembrane protein 15", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Im (Disease Ontology:DOID:0080565)", "pathway": " (mmu:227697); (R-MMU-446199)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31219806;35820727", "class_list": "glycogene", "function": "Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis. Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.108", "type": "external" } ], "go_molecular_function": "GO:0004168 dolichol kinase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2Y3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924S9-1", "uniprot_id": [ { "id": "DSCR6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924S9", "type": "external" } ], "mass": 16965.0, "length": 152, "protein_name": "Protein ripply3", "gene_name": "Ripply3", "organism": "Mouse", "refseq_name": "protein ripply3", "refseq_ac": [ { "id": "NP_573492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573492", "type": "external" } ], "gene_names_uniprotkb": "Ripply3; Dscr6", "gene_names_refseq": "Dscr6; Ripply3", "protein_names_uniprotkb": "Protein ripply3; Down syndrome critical region protein 6", "protein_names_refseq": "Down syndrome critical region homolog 6; down syndrome critical region protein 6; homolog of human Down syndrome critical region gene 6 DSCR6; protein ripply3; ripply3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:170765)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16326386;21177346;33452727", "class_list": "", "function": "Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives., [UniProtKB, PubMed]; Effect of retinoic acid signaling on Ripply3 expression and pharyngeal arch morphogenesis in mouse embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JK62;Q8BYB3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0060037 pharyngeal system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q924S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XQ8-1", "uniprot_id": [ { "id": "F168B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XQ8", "type": "external" } ], "mass": 20194.0, "length": 194, "protein_name": "Myelin-associated neurite-outgrowth inhibitor", "gene_name": "Fam168b", "organism": "Mouse", "refseq_name": "myelin-associated neurite-outgrowth inhibitor isoform 1", "refseq_ac": [ { "id": "NP_001153707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153707", "type": "external" } ], "gene_names_uniprotkb": "Fam168b; Kiaa4042", "gene_names_refseq": "Fam168b; Mani; mKIAA4042", "protein_names_uniprotkb": "Myelin-associated neurite-outgrowth inhibitor; Mani", "protein_names_refseq": "myelin-associated neurite-outgrowth inhibitor isoform 1; myelin-associated neurite-outgrowth inhibitor; protein FAM168B", "tax_id": 10090, "disease": "", "pathway": " (mmu:214469)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20716133;21750661;26495903", "class_list": "", "function": "Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNC7;Q5DTR7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0030182 neuron differentiation;GO:0022008 neurogenesis;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80XQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYH6-1", "uniprot_id": [ { "id": "MAGD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYH6", "type": "external" } ], "mass": 85670.0, "length": 775, "protein_name": "Melanoma-associated antigen D1", "gene_name": "Maged1", "organism": "Mouse", "refseq_name": "melanoma-associated antigen D1", "refseq_ac": [ { "id": "NP_062765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062765", "type": "external" } ], "gene_names_uniprotkb": "Maged1; Nrage", "gene_names_refseq": "2810433C11Rik; 5430405L04Rik; DXBwg1492e; Dlixin; Dlxin-1; Dlxin1; MAGE-D1; Maged1; NRAGE", "protein_names_uniprotkb": "Melanoma-associated antigen D1; Dlxin-1; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog", "protein_names_refseq": "MAGE-D1 antigen; melanoma antigen, family D, 1; melanoma-associated antigen D1; neurotrophin receptor-interacting MAGE homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:94275); (R-MMU-9768919)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11084035;20300063;25428506;25605945;30084848;30779550;31219806;34428180;34887587;35822049;36774489;40885482", "class_list": "", "function": "Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed., [UniProtKB, PubMed]; The deficiency of Maged1 attenuates Parkinson's disease progression in mice. Erratum:[Mol Brain. 2024 Feb 9;17(1):6. doi: 10.1186/s13041-023-01075-1. PMID: 38336723] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q543L6;Q99PB5;Q9CYX1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:1900181 negative regulation of protein localization to nucleus;GO:0045892 negative regulation of DNA-templated transcription;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QYH6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHN9-1", "uniprot_id": [ { "id": "NDST1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHN9", "type": "external" } ], "mass": 100726.0, "length": 882, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "gene_name": "Ndst1", "organism": "Mouse", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_001335029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335029", "type": "external" } ], "gene_names_uniprotkb": "Ndst1", "gene_names_refseq": "1200015G06Rik; HSNST 1; HSNST; Hsst; N-HSST 1; N-HSST; NDST-1; Ndst1; b2b2230Clo", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; NDST-1; [Heparan sulfate]-glucosamine N-sulfotransferase 1", "protein_names_refseq": "N-heparan sulfate sulfotransferase 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 46 (Disease Ontology:DOID:0081210); intellectual disability (Disease Ontology:DOID:1059); DiGeorge syndrome (Disease Ontology:DOID:11198); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:15531); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10664446;10758005;10852901;11087757;12590599;12634318;12692154;16020517;16056228;18337501;21750661;34428180;37747931;9565617", "class_list": "glycogene", "function": "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:10664446, PubMed:10758005, PubMed:11087757, PubMed:12590599, PubMed:12692154, PubMed:16020517, PubMed:16056228, PubMed:18337501). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (Probable). Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:16056228). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70353;Q3TBX3;Q3TDS3;Q8BZE5;Q9R206", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006477 protein sulfation;GO:0045880 positive regulation of smoothened signaling pathway;GO:0000271 polysaccharide biosynthetic process;GO:0006954 inflammatory response;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UHN9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2W0-1", "uniprot_id": [ { "id": "DNPEP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2W0", "type": "external" } ], "mass": 52207.0, "length": 473, "protein_name": "Aspartyl aminopeptidase", "gene_name": "Dnpep", "organism": "Mouse", "refseq_name": "aspartyl aminopeptidase isoform a", "refseq_ac": [ { "id": "NP_001104301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104301", "type": "external" } ], "gene_names_uniprotkb": "Dnpep", "gene_names_refseq": "Dnpep", "protein_names_uniprotkb": "Aspartyl aminopeptidase; 3.4.11.21", "protein_names_refseq": "aspartyl aminopeptidase isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:13437)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11903661;21576357;21750661;25428506;29122955;30084848;34428180;9632644", "class_list": "", "function": "Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dietary fatty acids affect activity in mouse testis, [RefSeq, PubMed]; Results demonstrate that Mir140 is essential for normal endochondral bone development and suggest that the reduced BMP signaling caused by Dnpep upregulation plays a causal role in the skeletal defects of Mir140-null mice., [RefSeq, PubMed]; Study shows that in the absence of aspartyl aminopeptidase (DNPEP), the kidney lysates retain their ability to cleave STE20/SPS1-related proline/alanine-rich kinase(SPAK), indicating that DNPEP might have been misidentified as the protease behind the kidney lysate activity, or that the aspartyl aminopeptidase might not be the only protease cleaving SPAK in kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56A00", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z2W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESV0-1", "uniprot_id": [ { "id": "DDX24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESV0", "type": "external" } ], "mass": 96429.0, "length": 857, "protein_name": "ATP-dependent RNA helicase DDX24", "gene_name": "Ddx24", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX24 isoform 1", "refseq_ac": [ { "id": "NP_001152974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152974", "type": "external" } ], "gene_names_uniprotkb": "Ddx24", "gene_names_refseq": "1700055J08Rik; 2510027P10Rik; Ddx24", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX24; 3.6.4.13; DEAD box protein 24", "protein_names_refseq": "ATP-dependent RNA helicase DDX24 isoform 1; ATP-dependent RNA helicase DDX24; DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; DEAD box protein 24; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)", "tax_id": 10090, "disease": "", "pathway": " (mmu:27225)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10936056;16479539;17242355;19144319;21183079;21750661;22645316;22872234;24204270;31219806;34203471;34428180;36210013;37470182;38354508;38612434", "class_list": "", "function": "ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App[N-LF] Mice and Influences Presymptomatic Pathology. Publication Status: Online-Only, [RefSeq, PubMed]; Data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease., [RefSeq, PubMed]; Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability., [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61119;Q7TM97", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9ESV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60755-1", "uniprot_id": [ { "id": "MDGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P60755", "type": "external" } ], "mass": 106689.0, "length": 949, "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2", "gene_name": "Mdga2", "organism": "Mouse", "refseq_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform B precursor", "refseq_ac": [ { "id": "NP_996893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996893", "type": "external" } ], "gene_names_uniprotkb": "Mdga2; Mamdc1", "gene_names_refseq": "6720489L24Rik; 9330209L04Rik; Adp; Mamdc1; Mdga2; Tg(Prnp-PFN1*G118V)838Kiaei", "protein_names_uniprotkb": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1", "protein_names_refseq": "MAM domain containing 1; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform B precursor; MAM domain-containing glycosylphosphatidylinositol anchor protein 2; acrodysplasia", "tax_id": 10090, "disease": "", "pathway": " (mmu:320772); (R-MMU-163125)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22281501;23248271;23358245;30899004;33300544;37499910", "class_list": "", "function": "Early postnatal development of the MDGA2[+/-] mouse model of synaptic dysfunction., [RefSeq, PubMed]; MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and not neuroligin-1 excitatory synapse organizer., [RefSeq, PubMed]; May be involved in cell-cell interactions., [UniProtKB, UniProtKB, UniProtKB]; The transgene was inserted into the intronic sequences between exon 3 and exon 4 of the Mdga2 gene;the transgene was highly or under methylated in normal and deformed mice, respectively., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098839 postsynaptic density membrane;GO:0098552 side of membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0050905 neuromuscular process;GO:0001764 neuron migration;GO:0043524 negative regulation of neuron apoptotic process;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P60755-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34960-1", "uniprot_id": [ { "id": "MMP12_MOUSE", "url": "https://www.uniprot.org/uniprot/P34960", "type": "external" } ], "mass": 54971.0, "length": 473, "protein_name": "Macrophage metalloelastase", "gene_name": "Mmp12", "organism": "Mouse", "refseq_name": "macrophage metalloelastase isoform 2", "refseq_ac": [ { "id": "NP_001307005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307005", "type": "external" } ], "gene_names_uniprotkb": "Mmp12; Mmel; Mme", "gene_names_refseq": "MME; Mmel; Mmp12", "protein_names_uniprotkb": "Macrophage metalloelastase; 3.4.24.65; MME; MMP-12; Matrix metalloproteinase-12", "protein_names_refseq": "macrophage elastase; macrophage metalloelastase isoform 2; macrophage metalloelastase; matrix metalloproteinase 12", "tax_id": 10090, "disease": "crescentic glomerulonephritis (Disease Ontology:DOID:13139); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); coronary aneurysm (Disease Ontology:DOID:3362); coronary artery disease (Disease Ontology:DOID:3393); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); abdominal aortic aneurysm (Disease Ontology:DOID:7693); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:17381); (R-MMU-1442490); (R-MMU-1474228)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1537850;21750661;31219806;38542140;39456786", "class_list": "", "function": "Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity)., [UniProtKB]; RNA Expression of MMP12 Is Strongly Associated with Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7 Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB28;Q3TBV6;Q3TBV9;Q3TD61;Q3U1S8;Q3U1S9;Q3U2R8;Q3UBC5;Q4FJM7;Q8BJ92;Q8BJB3;Q8BJB6;Q8BJB8;Q8BJB9;Q8VED6", "ec_number_list": [ { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0050691 regulation of defense response to virus by host;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P34960-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK26-1", "uniprot_id": [ { "id": "FBX44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK26", "type": "external" } ], "mass": 29723.0, "length": 255, "protein_name": "F-box only protein 44", "gene_name": "Fbxo44", "organism": "Mouse", "refseq_name": "F-box only protein 44 isoform 1", "refseq_ac": [ { "id": "NP_001155323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155323", "type": "external" } ], "gene_names_uniprotkb": "Fbxo44; Fbxo6a", "gene_names_refseq": "5730411K09; FBG3; FBX30; Fbx6a; Fbxo44; Fbxo6a", "protein_names_uniprotkb": "F-box only protein 44; F-box only protein 6a", "protein_names_refseq": "F-box only protein 44 isoform 1; F-box only protein 44; F-box only protein 6a", "tax_id": 10090, "disease": "", "pathway": " (mmu:230903); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18203720;21750661;25970626;30016717", "class_list": "glycogene", "function": "FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex. The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation. In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation. Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K128", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BK26-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2K1-1", "uniprot_id": [ { "id": "FUCM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2K1", "type": "external" } ], "mass": 16805.0, "length": 153, "protein_name": "Fucose mutarotase", "gene_name": "Fuom", "organism": "Mouse", "refseq_name": "fucose mutarotase isoform 2", "refseq_ac": [ { "id": "NP_001273146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273146", "type": "external" } ], "gene_names_uniprotkb": "Fuom; 1810014F10Rik; Le51", "gene_names_refseq": "Fucu; Fuom; Le51", "protein_names_uniprotkb": "Fucose mutarotase; 5.1.3.29", "protein_names_refseq": "fucose mutarotase isoform 2; protein fucU homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69064); (R-MMU-6787639)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15052633;17602138;19524593;20609214;21750661", "class_list": "", "function": "Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The mouse FucU assembles into four different oligomeric forms, among which the smallest homodimeric form is most abundant and would be the predominant species under physiological conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQB6;Q76K68;Q8C566;Q8C8P5", "ec_number_list": [ { "id": "5.1.3.29", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.29", "type": "external" } ], "go_molecular_function": "GO:0042806 fucose binding;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0036373 L-fucose mutarotase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0060180 female mating behavior;GO:0045665 negative regulation of neuron differentiation;GO:0006004 fucose metabolic process;GO:0005996 monosaccharide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R2K1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TLR7-1", "uniprot_id": [ { "id": "DTL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TLR7", "type": "external" } ], "mass": 79131.0, "length": 729, "protein_name": "Denticleless protein homolog", "gene_name": "Dtl", "organism": "Mouse", "refseq_name": "denticleless protein homolog isoform 2", "refseq_ac": [ { "id": "NP_001292162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292162", "type": "external" } ], "gene_names_uniprotkb": "Dtl; Cdt2; L2dtl; Ramp", "gene_names_refseq": "2810047L02Rik; 5730564G15Rik; Dtl; L2dtl; Ramp", "protein_names_uniprotkb": "Denticleless protein homolog; Lethal(2) denticleless protein homolog; Meth A RAMP; Meth A retinoic acid-regulated nuclear matrix-associated protein; Retinoic acid-regulated nuclear matrix-associated protein", "protein_names_refseq": "Meth A ramp; Sarcoma antigen S35; denticleless homolog; denticleless protein homolog isoform 2; lethal(2) denticleless protein homolog; meth A retinoic acid-regulated nuclear matrix-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76843); (R-MMU-110314); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12707369;17107960;17242355;18299400;21183079;21750661;21952136;24699724;25428506;30084848;34203471;34428180;35711069;37828378;38609375", "class_list": "", "function": "L2dtl gene expression is essential for very early mouse embryonic development, [RefSeq, PubMed]; Mice lacking DCAF2 in placenta die at the gastrulation stage., [RefSeq, PubMed]; RUVBL1 ubiquitination by DTL promotes RUVBL1/2-beta-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity)., [UniProtKB, UniProtKB]; While interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTE9;Q6PAN1;Q80WY1;Q80WY2;Q8BW38;Q9CZ76", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3TLR7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDH1-1", "uniprot_id": [ { "id": "FBX21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDH1", "type": "external" } ], "mass": 72173.0, "length": 627, "protein_name": "F-box only protein 21", "gene_name": "Fbxo21", "organism": "Mouse", "refseq_name": "F-box only protein 21 isoform 2", "refseq_ac": [ { "id": "NP_001333517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333517", "type": "external" } ], "gene_names_uniprotkb": "Fbxo21; Fbx21; Kiaa0875", "gene_names_refseq": "2810425J22Rik; Fbxo21", "protein_names_uniprotkb": "F-box only protein 21", "protein_names_refseq": "F-box only protein 21 isoform 2; F-box only protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:231670); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;27063938;31219806;34428180;35987460", "class_list": "", "function": "Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]; Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHA5;Q8CHC6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:0060218 hematopoietic stem cell differentiation;GO:0070371 ERK1 and ERK2 cascade;GO:0019221 cytokine-mediated signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VDH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVJ9-1", "uniprot_id": [ { "id": "FBLN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVJ9", "type": "external" } ], "mass": 49425.0, "length": 443, "protein_name": "EGF-containing fibulin-like extracellular matrix protein 2", "gene_name": "Efemp2", "organism": "Mouse", "refseq_name": "EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_067449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067449", "type": "external" } ], "gene_names_uniprotkb": "Efemp2; Fbln4; Mbp1", "gene_names_refseq": "0610011K11Rik; Efemp2; Fbln4; MBP1", "protein_names_uniprotkb": "EGF-containing fibulin-like extracellular matrix protein 2; FIBL-4; Fibulin-4; Mutant p53-binding protein 1", "protein_names_refseq": "EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2); EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor; FIBL-4; fibulin-4; mutant p53-binding protein 1", "tax_id": 10090, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); autosomal recessive cutis laxa type IB (Disease Ontology:DOID:0070133); aortic dissection (Disease Ontology:DOID:0080685); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); cervix carcinoma (Disease Ontology:DOID:2893); cutis laxa (Disease Ontology:DOID:3144); osteosarcoma (Disease Ontology:DOID:3347); bone osteosarcoma (Disease Ontology:DOID:3376); aortic aneurysm (Disease Ontology:DOID:3627); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:58859); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10380882;16478991;17324935;19855011;20019329;21750661;23636094;25713297;26178373;26220971;26486174;26690653;26711913;28508064;28717224;33239290;36565192;37267118", "class_list": "", "function": "A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase. Publication Status: Online-Only, [RefSeq, PubMed]; Changes in transmural mass transport correlate with ascending thoracic aortic aneurysm diameter in a fibulin-4 E57K knockin mouse model., [RefSeq, PubMed]; Fibulin-4 plays an irreplaceable role in elastogenesis., [RefSeq, PubMed]; Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:16478991, PubMed:19855011, PubMed:20019329, PubMed:26486174, PubMed:26711913, PubMed:28508064). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (PubMed:26178373, PubMed:26220971, PubMed:26690653, PubMed:26711913). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:17324935). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23636094)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:1905609 positive regulation of smooth muscle cell-matrix adhesion;GO:0060840 artery development;GO:0035904 aorta development;GO:0097084 vascular associated smooth muscle cell development;GO:0048251 elastic fiber assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9WVJ9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6M3-1", "uniprot_id": [ { "id": "GHC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6M3", "type": "external" } ], "mass": 34670.0, "length": 323, "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "Slc25a22", "organism": "Mouse", "refseq_name": "mitochondrial glutamate carrier 1 isoform a", "refseq_ac": [ { "id": "NP_001171047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171047", "type": "external" } ], "gene_names_uniprotkb": "Slc25a22; Gc1", "gene_names_refseq": "1300006L01Rik; Gc1; Slc25a22", "protein_names_uniprotkb": "Mitochondrial glutamate carrier 1; GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22", "protein_names_refseq": "glutamate/H(+) symporter 1; mitochondrial glutamate carrier 1 isoform a; mitochondrial glutamate carrier 1; solute carrier family 25 member 22", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 3 (Disease Ontology:DOID:0080440)", "pathway": " (mmu:68267); (R-MMU-442660); (R-MMU-9856872)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32814111;33300544;34428180;37453647", "class_list": "", "function": "In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance., [RefSeq, PubMed]; Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity). Plays a role in the control of glucose-stimulated insulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRY1", "ec_number_list": [], "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D6M3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZD6-1", "uniprot_id": [ { "id": "EAF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZD6", "type": "external" } ], "mass": 29187.0, "length": 262, "protein_name": "ELL-associated factor 2", "gene_name": "Eaf2", "organism": "Mouse", "refseq_name": "ELL-associated factor 2 isoform b", "refseq_ac": [ { "id": "NP_001106872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106872", "type": "external" } ], "gene_names_uniprotkb": "Eaf2; Festa; Traits", "gene_names_refseq": "Eaf2; FESTA-L; FESTA-S; Festa; Traits; U19", "protein_names_uniprotkb": "ELL-associated factor 2; Ehrlich S-II transcriptional activator factor; Testosterone-regulated apoptosis inducer and tumor suppressor protein", "protein_names_refseq": "ELL-associated factor 2 isoform b; ehrlich S-II transcriptional activator factor; testosterone regulated apoptosis inducer and tumor suppressor; testosterone-regulated apoptosis inducer and tumor suppressor protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:106389); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12761297;12907652;14517999;17873910;17892859;21750661;26935903;29029019", "class_list": "", "function": "Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity., [UniProtKB, PubMed]; Data show that p53 and EAF2 knockout mice developed prostate cancer., [RefSeq, PubMed]; Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia, [RefSeq, PubMed]; Expression of Eaf2 is developmentally regulated., [RefSeq, PubMed]; These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II, was decreased in RNA polymerase II deficient embryonic stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN80;Q99KD2", "ec_number_list": [], "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0032783 super elongation complex", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91ZD6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55087-1", "uniprot_id": [ { "id": "MEF2B_MOUSE", "url": "https://www.uniprot.org/uniprot/O55087", "type": "external" } ], "mass": 37435.0, "length": 349, "protein_name": "Myocyte-specific enhancer factor 2B", "gene_name": "Mef2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mef2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2B", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:105980076); (R-MMU-525793)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11585834;21750661;7646512;8668199;9443808", "class_list": "", "function": "Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O55088;O55089;O55090;O55231;Q61843", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030054 cell junction;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55087-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYU6-1", "uniprot_id": [ { "id": "DPH7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYU6", "type": "external" } ], "mass": 53201.0, "length": 477, "protein_name": "Diphthine methyltransferase", "gene_name": "Dph7", "organism": "Mouse", "refseq_name": "diphthine methyltransferase isoform a", "refseq_ac": [ { "id": "NP_080320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080320", "type": "external" } ], "gene_names_uniprotkb": "Dph7; Wdr85", "gene_names_refseq": "2810443J12Rik; Dph7; Wdr85", "protein_names_uniprotkb": "Diphthine methyltransferase; 3.1.1.97; DPH7; Diphthamide biosynthesis protein 7; WD repeat-containing protein 85", "protein_names_refseq": "WD repeat domain 85; WD repeat-containing protein 85; WD40 repeat domain 85; diphthamide biosynthesis protein 7; diphthine methyltransferase isoform a; diphthine methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67228)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ86;Q5RJV7;Q8BIT9", "ec_number_list": [ { "id": "3.1.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.97", "type": "external" } ], "go_molecular_function": "GO:0061685 diphthine methylesterase activity;GO:0051723 protein methylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CYU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNF0-1", "uniprot_id": [ { "id": "DOC2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNF0", "type": "external" } ], "mass": 44609.0, "length": 405, "protein_name": "Double C2-like domain-containing protein alpha", "gene_name": "Doc2a", "organism": "Mouse", "refseq_name": "double C2-like domain-containing protein alpha", "refseq_ac": [ { "id": "NP_034199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034199", "type": "external" } ], "gene_names_uniprotkb": "Doc2a", "gene_names_refseq": "Doc2a", "protein_names_uniprotkb": "Double C2-like domain-containing protein alpha; Doc2-alpha", "protein_names_refseq": "doc2-alpha; double C2-like domain-containing protein alpha", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:13446)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18354201;20150444;21750661;25428506;33753311;37354460;38242640;38536730", "class_list": "", "function": "16p11.2 CNV gene Doc2alpha functions in neurodevelopment and social behaviors through interaction with Secretagogin., [RefSeq, PubMed]; Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons., [RefSeq, PubMed]; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells., [UniProtKB, PubMed, PubMed]; Disease-linked mutations in Munc18-1 deplete synaptic Doc2., [RefSeq, PubMed]; Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2alpha-triggered asynchronous release. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0043005 neuron projection", "go_biological_process": "GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0061669 spontaneous neurotransmitter secretion;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TNF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3P2-1", "uniprot_id": [ { "id": "DTX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3P2", "type": "external" } ], "mass": 67195.0, "length": 619, "protein_name": "Probable E3 ubiquitin-protein ligase DTX2", "gene_name": "Dtx2", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase DTX2 isoform 1", "refseq_ac": [ { "id": "NP_001243025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243025", "type": "external" } ], "gene_names_uniprotkb": "Dtx2", "gene_names_refseq": "2610524D08Rik; Deltex2; Dtx2", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase DTX2; 2.3.2.27; Deltex2; Protein deltex-2; RING-type E3 ubiquitin transferase DTX2; mDTX2", "protein_names_refseq": "RING-type E3 ubiquitin transferase DTX2; deltex 2 homolog; mDTX2; probable E3 ubiquitin-protein ligase DTX2 isoform 1; probable E3 ubiquitin-protein ligase DTX2; protein deltex-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74198); (R-MMU-2122948)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11226752;12185365;19224205;20173027;21750661;25428506;26495903;30084848;30779550;31219806;31599954;34428180;35820727;41772062", "class_list": "", "function": "E3 ubiquitin ligase that conjugates ubiquitin to ADP-ribosylated cysteine residues, independently of lysine side chains or free N-termini. For example, PARP7 generates an ADP-ribosyl degron within the DNA-binding domain of the androgen receptor (AR), which is recognized by DTX2 and targeted for proteasomal degradation. Functions in genome stability maintenance by acting as an ADP-ribosylation-dependent regulator of DNA double-strand break repair. Mechanistically, recognizes PARylated substrates generated in response to DNA damage and promotes their ubiquitination via its RING and DTC domains. Also regulates additional cellular pathways through ubiquitination of specific substrates. Acts as an E3 ubiquitin ligase for RNA demethylase FTO, promoting its ubiquitination and proteasomal degradation. In turn, regulates antitumor immune responses. Promotes 'Lys-27'-linked ubiquitination of TFRC, thereby modulating iron metabolism and inhibiting ferroptosis (PubMed:41772062). In addition, promotes transcription of telomerase reverse transcriptase by mediating 'Lys-63'-linked ubiquitination of nuclear factor 1 C-type (NFIC) that stabilizes its binding on hTERT promoter., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZV3;Q9ER07;Q9ER08", "ec_number_list": [ { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R3P2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNQ3-1", "uniprot_id": [ { "id": "G137B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNQ3", "type": "external" } ], "mass": 44055.0, "length": 385, "protein_name": "Integral membrane protein GPR137B", "gene_name": "Gpr137b", "organism": "Mouse", "refseq_name": "integral membrane protein GPR137B", "refseq_ac": [ { "id": "NP_114388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114388", "type": "external" } ], "gene_names_uniprotkb": "Gpr137b; Tm7sf1", "gene_names_refseq": "C730041E01; D13Abb1e; Gpr137b; Tm7sf1", "protein_names_uniprotkb": "Integral membrane protein GPR137B; Transmembrane 7 superfamily member 1 protein", "protein_names_refseq": "integral membrane protein GPR137B; transmembrane 7 superfamily member 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83924)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19144319;21750661;30595385;31173907;32482387;34428180;36210013;37767704", "class_list": "", "function": "A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish., [RefSeq, PubMed]; Also acts as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385)., [UniProtKB, PubMed, PubMed]; Gpr137b is involved in interleukin-4-induced M2 macrophage polarization. Gpr137b is not involved in lipopolysaccharide-induced M1 macrophage polarization., [RefSeq, PubMed]; Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages. Erratum:[Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):e116. doi: 10.1161/ATV.0000000000000170. PMID: 38381855], [RefSeq, PubMed]; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomal localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Also acts as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385)., [UniProtKB, UniProtKB, PubMed, PubMed]; TM7SF1, an important autophagy regulatory protein in mouse podocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9U4;Q99LK4;Q9JHD9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010506 regulation of autophagy;GO:0006914 autophagy;GO:0045671 negative regulation of osteoclast differentiation;GO:0045779 negative regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BNQ3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71FD7-1", "uniprot_id": [ { "id": "FBLI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q71FD7", "type": "external" } ], "mass": 41026.0, "length": 375, "protein_name": "Filamin-binding LIM protein 1", "gene_name": "Fblim1", "organism": "Mouse", "refseq_name": "filamin-binding LIM protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001156728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156728", "type": "external" } ], "gene_names_uniprotkb": "Fblim1; Cal", "gene_names_refseq": "2410043F08Rik; Cal; Fblim1; Fblp1; Gt10; migfilin(s); migfilin", "protein_names_uniprotkb": "Filamin-binding LIM protein 1; CSX-associated LIM; FBLP-1", "protein_names_refseq": "CSX-associated LIM; FBLP-1; filamin-binding LIM protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74202); (R-MMU-446353)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14757752;21750661;24165133;25852081;29114925", "class_list": "", "function": "C-terminal LIM domains of migfilin dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin dynamics., [RefSeq, PubMed]; Findings indicate that tightly regulated expression of migfilin is essential for neuronal development and that FBLIM1 disruption may be related to the phenotypes associated with ASD and related neurodevelopmental disorders., [RefSeq, PubMed]; Results suggest that a novel LIM protein Cal induces cardiomyocyte differentiation through its dynamic intracellular shuttling and association with CSX/NKX2-5, [RefSeq, PubMed]; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity)., [UniProtKB]; Suggest migfilin regulates cardiac hypertrophy in transverse aortic constriction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDK3;Q99J35", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0030054 cell junction;GO:0001650 fibrillar center;GO:0001725 stress fiber", "go_biological_process": "GO:0033623 regulation of integrin activation;GO:0098609 cell-cell adhesion;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q71FD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88174-1", "uniprot_id": [ { "id": "MCP_MOUSE", "url": "https://www.uniprot.org/uniprot/O88174", "type": "external" } ], "mass": 40881.0, "length": 365, "protein_name": "Membrane cofactor protein", "gene_name": "Cd46", "organism": "Mouse", "refseq_name": "membrane cofactor protein precursor", "refseq_ac": [ { "id": "NP_034908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034908", "type": "external" } ], "gene_names_uniprotkb": "Cd46; Mcp", "gene_names_refseq": "Cd46; Mcp", "protein_names_uniprotkb": "Membrane cofactor protein", "protein_names_refseq": "membrane cofactor protein precursor; membrane cofactor protein", "tax_id": 10090, "disease": "meningococcal meningitis (Disease Ontology:DOID:0080176); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pre-eclampsia (Disease Ontology:DOID:10591); age related macular degeneration (Disease Ontology:DOID:10871); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); multiple sclerosis (Disease Ontology:DOID:2377); thrombophilia (Disease Ontology:DOID:2452); contact dermatitis (Disease Ontology:DOID:2773); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); viral infectious disease (Disease Ontology:DOID:934); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:17221); (R-MMU-977606)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10630288;12640142;21750661;37579982;37944208;9461505;9799332", "class_list": "", "function": "CD46 expression in the central nervous system of male and female pubescent mice., [RefSeq, PubMed]; May be involved in the fusion of the spermatozoa with the oocyte during fertilization., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The association between CD46 expression in B cells and the pathogenesis of airway allergy., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0R9", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0007338 single fertilization;GO:0071636 positive regulation of transforming growth factor beta production;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88174-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02395-1", "uniprot_id": [ { "id": "MTF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02395", "type": "external" } ], "mass": 66924.0, "length": 593, "protein_name": "Metal-response element-binding transcription factor 2", "gene_name": "Mtf2", "organism": "Mouse", "refseq_name": "metal-response element-binding transcription factor 2 isoform 2", "refseq_ac": [ { "id": "NP_001240806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240806", "type": "external" } ], "gene_names_uniprotkb": "Mtf2; Pcl2", "gene_names_refseq": "9230112N11Rik; M96; Mtf2; Pcl2", "protein_names_uniprotkb": "Metal-response element-binding transcription factor 2; Metal regulatory transcription factor 2; Metal-response element DNA-binding protein M96; Polycomb-like protein 2; ZiRF1; Zinc-regulated factor 1; mPCl2", "protein_names_refseq": "mPCl2; metal regulatory transcription factor 2; metal response element DNA-binding protein M96; metal-response element-binding transcription factor 2 isoform 2; polycomb-like protein 2; ziRF1; zinc-regulated factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17765); (R-MMU-212300)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "20144788;21059868;21367819;21750661;22438827;23104054;31219806;33887196;34428180;34848733;34876184;7772254;9173905", "class_list": "", "function": "Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation., [RefSeq, PubMed]; Loss of PRC2 subunits primes lineage choice during exit of pluripotency. Publication Status: Online-Only, [RefSeq, PubMed]; Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21059868, PubMed:21367819, PubMed:22438827, PubMed:23104054). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; WDR26 and MTF2 are therapeutic targets in multiple myeloma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05C61;Q569Z8;Q6PG89;Q8BGP9;Q8BSJ7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048863 stem cell differentiation;GO:1990830 cellular response to leukemia inhibitory factor;GO:0019827 stem cell population maintenance;GO:0007379 segment specification;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02395-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62830-1", "uniprot_id": [ { "id": "RL23_MOUSE", "url": "https://www.uniprot.org/uniprot/P62830", "type": "external" } ], "mass": 14865.0, "length": 140, "protein_name": "Large ribosomal subunit protein uL14", "gene_name": "Rpl23", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL14", "refseq_ac": [ { "id": "NP_075029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075029", "type": "external" } ], "gene_names_uniprotkb": "Rpl23", "gene_names_refseq": "2810009A01Rik; Rpl23", "protein_names_uniprotkb": "Large ribosomal subunit protein uL14; 60S ribosomal protein L23", "protein_names_refseq": "60S ribosomal protein L23; large ribosomal subunit protein uL14", "tax_id": 10090, "disease": "", "pathway": " (mmu:65019); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 21, "publication_id_list": "11124519;19224205;20173027;21750661;22645316;25428506;26740625;28011936;28315936;29187734;31219806;31599954;34428180;35820727;35984892;36517592;37453647;37507081;37828378;39627609;39927985", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23131;P24048;Q29246;Q3THU4;Q9CZE6;Q9DCQ4", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0001223 transcription coactivator binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P62830-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ11-1", "uniprot_id": [ { "id": "EXO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ11", "type": "external" } ], "mass": 92022.0, "length": 837, "protein_name": "Exonuclease 1", "gene_name": "Exo1", "organism": "Mouse", "refseq_name": "exonuclease 1", "refseq_ac": [ { "id": "NP_036142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036142", "type": "external" } ], "gene_names_uniprotkb": "Exo1", "gene_names_refseq": "5730442G03Rik; Exo1; Msa", "protein_names_uniprotkb": "Exonuclease 1; 3.1.-.-; Exonuclease I; mExo1", "protein_names_refseq": "exonuclease 1; exonuclease I; mExo1", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:26909); (R-MMU-5358565); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "10497278;12629043;14716311;21750661;35849338;38126949", "class_list": "", "function": "5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-beta1/Smad signaling feedback loop. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in mutation avoidance and is essential for male and female meiosis., [RefSeq, PubMed]; Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLM4;Q923A5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0006310 DNA recombination;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0006298 mismatch repair;GO:0006139 nucleobase-containing compound metabolic process;GO:0016446 somatic hypermutation of immunoglobulin genes", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZ11-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03172-1", "uniprot_id": [ { "id": "ZEP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03172", "type": "external" } ], "mass": 288344.0, "length": 2688, "protein_name": "Zinc finger protein 40", "gene_name": "Hivep1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hivep1; Cryabp1; Znf40", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 40; Alpha A-CRYBP1; Alpha A-crystallin-binding protein 1; Alpha A-crystallin-binding protein I; Transcription factor alphaA-CRYBP1", "protein_names_refseq": "", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:110521)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "1694016;21183079;21750661;25428506;30084848;30779550;31219806;32782141;34428180;34678516;35822049;36084651;36583994;36852467;40885482;40997131;7836383", "class_list": "", "function": "Transcription factor which binds specifically to the palindromic sequence 5'-GGGAAATCCC-3' in the alpha-A crystallin promoter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q03172-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0K5-1", "uniprot_id": [ { "id": "GDC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0K5", "type": "external" } ], "mass": 36220.0, "length": 332, "protein_name": "Mitochondrial coenzyme A transporter SLC25A16", "gene_name": "Slc25a16", "organism": "Mouse", "refseq_name": "mitochondrial coenzyme A transporter SLC25A16 isoform 1", "refseq_ac": [ { "id": "NP_780403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780403", "type": "external" } ], "gene_names_uniprotkb": "Slc25a16", "gene_names_refseq": "3110021G18Rik; GDA; GDC; HGT.1; ML7; Slc25a16", "protein_names_uniprotkb": "Mitochondrial coenzyme A transporter SLC25A16; Solute carrier family 25 member 16", "protein_names_refseq": "graves disease carrier protein homolog; mitochondrial coenzyme A transporter SLC25A16 isoform 1; mitochondrial coenzyme A transporter SLC25A16; mitochondrial solute carrier protein homolog; solute carrier family 25 member 16", "tax_id": 10090, "disease": "Graves' disease (Disease Ontology:DOID:12361)", "pathway": " (mmu:73132); (R-MMU-199220)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria. Could mediate the import of coenzyme A from the cytosol into the mitochondrial matrix. Alternatively, it could function in the export of 3'-dephospho-CoA from the mitochondrial matrix to the cytosol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSS4;Q6P6K8", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process;GO:1990559 mitochondrial coenzyme A transmembrane transport;GO:0015880 coenzyme A transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C0K5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERA6-1", "uniprot_id": [ { "id": "TFP11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERA6", "type": "external" } ], "mass": 96305.0, "length": 838, "protein_name": "Tuftelin-interacting protein 11", "gene_name": "Tfip11", "organism": "Mouse", "refseq_name": "tuftelin-interacting protein 11", "refseq_ac": [ { "id": "NP_061253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061253", "type": "external" } ], "gene_names_uniprotkb": "Tfip11; Stip; Tip39", "gene_names_refseq": "2810002G02Rik; Srr1; TIP33; Tfip11; Tip39", "protein_names_uniprotkb": "Tuftelin-interacting protein 11; STIP-1; Septin and tuftelin-interacting protein 1; Tuftelin-interacting protein 39", "protein_names_refseq": "STIP-1; septin and tuftelin-interacting protein 1; tuftelin-interacting protein 11; tuftelin-interacting protein 33; tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD", "tax_id": 10090, "disease": "", "pathway": " (mmu:54723); (R-MMU-72163)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10806191;11063033;15345747;15868102;17242355;19165350;19857462;21183079;21750661;22243227;25428506;30084848;30779550;31219806;31599954;34428180;36210013;39627609", "class_list": "", "function": "A member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating mesenchymal stem cell function, [RefSeq, PubMed]; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix., [UniProtKB, PubMed, PubMed]; These data help define the mechanism of nuclear/nuclear speckle localization of the splicing factor TFIP11, with implications for it's function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD06", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0031333 negative regulation of protein-containing complex assembly;GO:0031214 biomineral tissue development;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9ERA6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97808-1", "uniprot_id": [ { "id": "FXYD5_MOUSE", "url": "https://www.uniprot.org/uniprot/P97808", "type": "external" } ], "mass": 19454.0, "length": 178, "protein_name": "FXYD domain-containing ion transport regulator 5", "gene_name": "Fxyd5", "organism": "Mouse", "refseq_name": "FXYD domain-containing ion transport regulator 5 isoform a precursor", "refseq_ac": [ { "id": "NP_001104543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104543", "type": "external" } ], "gene_names_uniprotkb": "Fxyd5; Oit2", "gene_names_refseq": "EF-8; Fxyd5; Oit2; RIC", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 5; EF-8; Ion channel homolog RIC; Oncoprotein-induced protein 2", "protein_names_refseq": "FXYD domain-containing ion transport regulator 5 isoform a precursor; dysadherin; ion channel homolog RIC; oncoprotein induced transcript 2; oncoprotein-induced protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18301)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16148001;17881459;21750661;35673579;38725858;9032278", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:16148001, PubMed:17881459). May increase NKA activity by increasing the apparent affinity for Na(+) (PubMed:17881459). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Dysadherin awakens mechanical forces and promotes colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; The dysadherin/FAK axis promotes individual cell migration in colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The role of FXYD5 in Na,K-ATPase activity, its cellular and tissue distribution, and its biochemical properties are reported., [RefSeq, PubMed]; This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDW1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0015459 potassium channel regulator activity;GO:0017080 sodium channel regulator activity;GO:0045296 cadherin binding;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97808-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U3N0-1", "uniprot_id": [ { "id": "MIER2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U3N0", "type": "external" } ], "mass": 59268.0, "length": 541, "protein_name": "Mesoderm induction early response protein 2", "gene_name": "Mier2", "organism": "Mouse", "refseq_name": "mesoderm induction early response protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001303628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303628", "type": "external" } ], "gene_names_uniprotkb": "Mier2; Kiaa1193", "gene_names_refseq": "2700087H15Rik; Mier2; mKIAA1193; mi-er2", "protein_names_uniprotkb": "Mesoderm induction early response protein 2; Mi-er2", "protein_names_refseq": "mesoderm induction early response 1, family member 2; mesoderm induction early response protein 2 isoform 1; mesoderm induction early response protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70427)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcriptional repressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJI0;Q66JU5;Q69ZP0;Q6NXL7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U3N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PV86-1", "uniprot_id": [ { "id": "MCTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PV86", "type": "external" } ], "mass": 106795.0, "length": 951, "protein_name": "Multiple C2 and transmembrane domain-containing protein 1", "gene_name": "Mctp1", "organism": "Mouse", "refseq_name": "multiple C2 and transmembrane domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_084450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084450", "type": "external" } ], "gene_names_uniprotkb": "Mctp1", "gene_names_refseq": "2810465F10Rik; Mctp1", "protein_names_uniprotkb": "Multiple C2 and transmembrane domain-containing protein 1", "protein_names_refseq": "multiple C2 and transmembrane domain-containing protein 1 isoform 1; multiple C2 and transmembrane domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;30217595;34428180", "class_list": "", "function": "Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity., [UniProtKB, UniProtKB]; We found that the Mctp1(dwnd) deletion affects the Nr2f1 gene located 1.4Mb away, downregulating transcription and protein expression in the embryonic cochlea. Remarkably, the Mctp1(dwnd) allele failed to complement a targeted inactivation allele of Nr2f1, and transheterozygotes or Mctp1(dwnd) homozygotes exhibit the same morphological defects observed in inner ears of Nr2f1 mutants, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0030336 negative regulation of cell migration;GO:0046928 regulation of neurotransmitter secretion;GO:1902883 negative regulation of response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9PV86-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UY23-1", "uniprot_id": [ { "id": "FDXA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UY23", "type": "external" } ], "mass": 70120.0, "length": 622, "protein_name": "Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog", "gene_name": "Fdxacb1", "organism": "Mouse", "refseq_name": "ferredoxin-fold anticodon-binding domain-containing protein 1 homolog", "refseq_ac": [ { "id": "NP_941077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941077", "type": "external" } ], "gene_names_uniprotkb": "Fdxacb1", "gene_names_refseq": "D630004A14Rik; Fdxacb1", "protein_names_uniprotkb": "Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog; FDX-ACDB domain-containing protein 1", "protein_names_refseq": "FDX-ACDB domain-containing protein 1; ferredoxin-fold anticodon-binding domain-containing protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:382137)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;21750661", "class_list": "", "function": "D630004A14Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14B93;Q8BUG6;Q8BZH7", "ec_number_list": [], "go_molecular_function": "GO:0070042 rRNA (uridine-N3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UY23-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DTY7-1", "uniprot_id": [ { "id": "F264_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DTY7", "type": "external" } ], "mass": 54067.0, "length": 469, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4", "gene_name": "Pfkfb4", "organism": "Mouse", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform 1", "refseq_ac": [ { "id": "NP_766607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766607", "type": "external" } ], "gene_names_uniprotkb": "Pfkfb4", "gene_names_refseq": "C230090D14; Pfkfb4", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; PFK/FBPase 4", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; PFK/FBPase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:270198); (R-MMU-9634600)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14623077;16311927;21750661;31219806;36127291;36476868", "class_list": "", "function": "Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence., [RefSeq, PubMed]; PFKFB4 facilitates palbociclib resistance in oestrogen receptor-positive breast cancer by enhancing stemness., [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5UD55;Q5UD56;Q5UD57;Q5Y296;Q6PFE8", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6DTY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESD7-1", "uniprot_id": [ { "id": "DYSF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESD7", "type": "external" } ], "mass": 237911.0, "length": 2090, "protein_name": "Dysferlin", "gene_name": "Dysf", "organism": "Mouse", "refseq_name": "dysferlin isoform 2", "refseq_ac": [ { "id": "NP_001071162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071162", "type": "external" } ], "gene_names_uniprotkb": "Dysf; Fer1l1", "gene_names_refseq": "2310004N10Rik; D6Pas3; Dysf", "protein_names_uniprotkb": "Dysferlin; Dystrophy-associated fer-1-like protein; Fer-1-like protein 1", "protein_names_refseq": "dysferlin isoform 2; dysferlin_a; dystrophy-associated fer-1-like protein; fer-1-like protein 1", "tax_id": 10090, "disease": "Miyoshi muscular dystrophy 1 (Disease Ontology:DOID:0070199); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); distal myopathy with anterior tibial onset (Disease Ontology:DOID:0111187); distal myopathy (Disease Ontology:DOID:11720); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:26903)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10508505;11234777;11891182;11959863;12736685;14506282;15835269;16550931;17607357;18096699;19380584;21750661;25428506;34428180;39011635;39138561;39927985", "class_list": "", "function": "Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains., [RefSeq, PubMed]; Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy., [RefSeq, PubMed]; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SJL/J mice show spontaneous myopathy and have a mutation in the dysferlin gene, a gene which is also mutated in human limb-girdle muscular dystrophy type 2B (LGMD2B), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAR3;Q80VT0;Q9QXC0", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0043403 skeletal muscle tissue regeneration;GO:0090279 regulation of calcium ion import;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9ESD7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0S1-1", "uniprot_id": [ { "id": "DI3L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0S1", "type": "external" } ], "mass": 120284.0, "length": 1053, "protein_name": "DIS3-like exonuclease 1", "gene_name": "Dis3l", "organism": "Mouse", "refseq_name": "DIS3-like exonuclease 1 isoform 1", "refseq_ac": [ { "id": "NP_001001295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001295", "type": "external" } ], "gene_names_uniprotkb": "Dis3l; Kiaa1955", "gene_names_refseq": "Dis3l", "protein_names_uniprotkb": "DIS3-like exonuclease 1; 3.1.13.1", "protein_names_refseq": "DIS3 mitotic control homolog-like; DIS3-like exonuclease 1 isoform 1; DIS3-like exonuclease 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213550)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18299400;21750661;25428506;30084848;30779550;31219806;34428180;36210013;38875746", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA., [UniProtKB, UniProtKB]; Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z56", "ec_number_list": [], "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036064 ciliary basal body;GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006396 RNA processing;GO:0006402 mRNA catabolic process;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C0S1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64467-1", "uniprot_id": [ { "id": "G3PT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64467", "type": "external" } ], "mass": 47657.0, "length": 440, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific", "gene_name": "Gapdhs", "organism": "Mouse", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform 2", "refseq_ac": [ { "id": "NP_032111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032111", "type": "external" } ], "gene_names_uniprotkb": "Gapdhs; Gapd-s; Gapds", "gene_names_refseq": "Gapd-s; Gapdhs; Gapds", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; 1.2.1.12; GAPDH-2; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase", "protein_names_refseq": "GAPDH-2; glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform 2; glyceraldehyde-3-phosphate dehydrogenase, testis-specific; spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; spermatogenic glyceraldehyde-3-phosphate dehydrogenase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:14447); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12604635;1375514;15546993;21540332;21750661;22645316;25605945;29025010;34428180;35984892;36210013;7736666", "class_list": "", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Gapds(-/-) males were infertile and had profound defects in sperm motility, exhibiting sluggish movement without forward progression., [RefSeq, PubMed]; TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis., [RefSeq, PubMed]; These results identify multiple signaling and metabolic defects that are likely contributors to male infertility and the absence of progressive sperm motility seen in mice lacking GAPDHS., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q60650", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium;GO:0035686 sperm fibrous sheath;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006006 glucose metabolic process;GO:0045821 positive regulation of glycolytic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q64467-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60330-1", "uniprot_id": [ { "id": "ESPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P60330", "type": "external" } ], "mass": 233035.0, "length": 2118, "protein_name": "Separin", "gene_name": "Espl1", "organism": "Mouse", "refseq_name": "separin", "refseq_ac": [ { "id": "NP_001014976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014976", "type": "external" } ], "gene_names_uniprotkb": "Espl1; Esp1; Kiaa0165", "gene_names_refseq": "Cerp; ESP1; Espl1; PRCE; SSE", "protein_names_uniprotkb": "Separin; 3.4.22.49; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; Separase", "protein_names_refseq": "Cut1/ESP1 related protein; caspase-like protein ESPL1; extra spindle poles-like 1 protein; separase; separin", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:105988); (R-MMU-2467813)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18232736;19124608;19144319;21183079;21750661;30779550;31219806;33777955;34428180;35712867", "class_list": "", "function": "Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity)., [UniProtKB]; MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6E3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0051307 meiotic chromosome separation;GO:0000278 mitotic cell cycle;GO:0006508 proteolysis;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P60330-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98064-1", "uniprot_id": [ { "id": "MASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P98064", "type": "external" } ], "mass": 79968.0, "length": 704, "protein_name": "Mannan-binding lectin serine protease 1", "gene_name": "Masp1", "organism": "Mouse", "refseq_name": "mannan-binding lectin serine protease 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_032581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032581", "type": "external" } ], "gene_names_uniprotkb": "Masp1; Crarf", "gene_names_refseq": "CCPII; Crarf; Masp1/3; Masp1", "protein_names_uniprotkb": "Mannan-binding lectin serine protease 1; 3.4.21.-; Complement-activating component of Ra-reactive factor; MASP-1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5", "protein_names_refseq": "MASP-1; complement factor MASP-3; complement-activating component of Ra-reactive factor; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine protease 1 isoform 2 precursor; mannan-binding lectin serine protease 1; mannose-binding lectin-associated serine protease 1; mannose-binding protein-associated serine protease; ra-reactive factor serine protease p100; raRF; serine protease 5", "tax_id": 10090, "disease": "3MC syndrome 1 (Disease Ontology:DOID:0060575)", "pathway": " (mmu:17174); (R-MMU-166662); (R-MMU-2855086); (R-MMU-3000480)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12847554;18424734;21750661;30084848;31361958;31399515;31599954;32152506;36052069;36988282;8133044;8439319", "class_list": "glycogene", "function": "MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity., [RefSeq, PubMed]; Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, PubMed]; Serine protease that activates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:31399515, PubMed:36988282). The alternative complement pathway acts as an amplification loop that enhances other complement pathways (PubMed:31399515, PubMed:36988282). Isoform MASP-3 specifically catalyzes cleavage and activation of factor D (CFD), the protease that initiates the alternative complement pathway (PubMed:31399515, PubMed:36988282)., [UniProtKB, PubMed, PubMed]; Serine protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:18424734, PubMed:31399515). The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. Following autoproteolytic processing in response to lectin-binding to pathogen carbohydrates, catalyzes cleavage and activation of MASP2, the next component of the lectin complement pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2RRH8;A2RRH9;Q8CD27;Q8CIR8;Q920S0", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.104", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.104", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P98064-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCM4-1", "uniprot_id": [ { "id": "DNAL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCM4", "type": "external" } ], "mass": 12023.0, "length": 105, "protein_name": "Dynein axonemal light chain 4", "gene_name": "Dnal4", "organism": "Mouse", "refseq_name": "dynein axonemal light chain 4 isoform 1", "refseq_ac": [ { "id": "NP_059498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059498", "type": "external" } ], "gene_names_uniprotkb": "Dnal4; Dnalc4", "gene_names_refseq": "D15Ertd424e; Dnal4; Dnalc4", "protein_names_uniprotkb": "Dynein axonemal light chain 4", "protein_names_refseq": "dynein axonemal light chain 4 isoform 1; dynein light chain 4, axonemal; dynein, axon, light chain 4; outer arm dynein light chain 4", "tax_id": 10090, "disease": "mirror movements 3 (Disease Ontology:DOID:0070639)", "pathway": " (mmu:54152); (R-MMU-177504)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54793;Q3V233;Q99K65", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex", "go_biological_process": "GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DCM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NSU3-1", "uniprot_id": [ { "id": "GL8D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NSU3", "type": "external" } ], "mass": 41990.0, "length": 371, "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "Glt8d1", "organism": "Mouse", "refseq_name": "glycosyltransferase 8 domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001159402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159402", "type": "external" } ], "gene_names_uniprotkb": "Glt8d1", "gene_names_refseq": "2410004H05Rik; 5430414N14Rik; Glt8d1", "protein_names_uniprotkb": "Glycosyltransferase 8 domain-containing protein 1; 2.4.1.-", "protein_names_refseq": "glycosyltransferase 8 domain-containing protein 1 isoform 1; glycosyltransferase 8 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76485)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26740625;29483533;36210013", "class_list": "glycogene;glycosyltransferase", "function": "GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons. Erratum:[Nat Commun. 2018 Nov 16;9(1):4905. doi: 10.1038/s41467-018-07401-9. PMID: 30446647] Publication Status: Online-Only, [RefSeq, PubMed]; In vitro, catalyzes the transfer of a galactose residue from UDP-galactose onto GalNAc and GlcNAc structures., [UniProtKB, UniProtKB]; This gene encodes a member of the glycosyltransferase family. The encoded protein is a type II transmembrane protein containing a glycosyltransferase 8 domain in the lumenal (C-terminal) portion. The specific function of this protein has not been determined. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV18;Q9CWT8", "ec_number_list": [], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NSU3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12813-1", "uniprot_id": [ { "id": "NR4A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P12813", "type": "external" } ], "mass": 64738.0, "length": 601, "protein_name": "Nuclear receptor subfamily 4 group A member 1", "gene_name": "Nr4a1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 4 group A member 1", "refseq_ac": [ { "id": "NP_034574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034574", "type": "external" } ], "gene_names_uniprotkb": "Nr4a1; Gfrp; Hmr; N10; Nur77", "gene_names_refseq": "GFRP1; Gfrp; Hbr-1; Hbr1; Hmr; N10; NGFI-B; NGFIB; NP10; NUR77-1; NUR77-2; Nr4a1; TIS1; TR3; nur77", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 1; Nuclear hormone receptor NUR/77; Nuclear protein N10; Orphan nuclear receptor HMR", "protein_names_refseq": "nuclear hormone receptor NUR/77; nuclear protein N10; nuclear receptor subfamily 4 group A member 1; orphan nuclear receptor HMR", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:15370); (R-MMU-198693); (R-MMU-383280)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "18690216;21750661;22427340;2555161;30134173;3186734;37001519;8164692", "class_list": "", "function": "In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7., [UniProtKB, PubMed]; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:37001519). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (PubMed:30134173). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:30134173). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (PubMed:22427340)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RSQ1-1", "uniprot_id": [ { "id": "GLBL3_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RSQ1", "type": "external" } ], "mass": 73922.0, "length": 649, "protein_name": "Beta-galactosidase-1-like protein 3", "gene_name": "Glb1l3", "organism": "Mouse", "refseq_name": "beta-galactosidase-1-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001106794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106794", "type": "external" } ], "gene_names_uniprotkb": "Glb1l3", "gene_names_refseq": "4921509F24Rik; Glb1l3", "protein_names_uniprotkb": "Beta-galactosidase-1-like protein 3; 3.2.1.23", "protein_names_refseq": "beta-galactosidase-1-like protein 3 precursor; beta-galactosidase-1-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70893); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21633714;21750661;25605945", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Early-onset downregulation of Glb1l3 in Rpe65-related disease. Impaired expression of Glb1l3 is mostly due to absence of chromophore 11-cis retinal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5X3", "ec_number_list": [ { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" } ], "go_molecular_function": "GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0005773 vacuole", "go_biological_process": "GO:0019388 galactose catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2RSQ1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX17-1", "uniprot_id": [ { "id": "GEMI5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX17", "type": "external" } ], "mass": 166592.0, "length": 1502, "protein_name": "Gem-associated protein 5", "gene_name": "Gemin5", "organism": "Mouse", "refseq_name": "gem-associated protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001160141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160141", "type": "external" } ], "gene_names_uniprotkb": "Gemin5", "gene_names_refseq": "C330013N08; Gemin5", "protein_names_uniprotkb": "Gem-associated protein 5; Gemin5", "protein_names_refseq": "gem-associated protein 5 isoform 1; gem-associated protein 5", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); neurodevelopmental disorder with cerebellar atrophy and motor dysfunction (Disease Ontology:DOID:0070443)", "pathway": " (mmu:216766); (R-MMU-191859)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;22645316;25605945;25911097;28528544;31219806;34428180;36210013;39337533;39627609", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex. Binds to the 7-methylguanosine cap of RNA molecules (By similarity). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (By similarity)., [UniProtKB, UniProtKB, PubMed]; This work both reveals a new autoregulatory pathway governing SMN expression, and identifies a new mechanism through which SMN can modulate specific mRNA expression via Gemin5., [RefSeq, PubMed]; Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPH2", "ec_number_list": [], "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006417 regulation of translation;GO:0006412 translation;GO:0000387 spliceosomal snRNP assembly;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BX17-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61508-1", "uniprot_id": [ { "id": "ECM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61508", "type": "external" } ], "mass": 62832.0, "length": 559, "protein_name": "Extracellular matrix protein 1", "gene_name": "Ecm1", "organism": "Mouse", "refseq_name": "extracellular matrix protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_031925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031925", "type": "external" } ], "gene_names_uniprotkb": "Ecm1", "gene_names_refseq": "Ecm1; p85", "protein_names_uniprotkb": "Extracellular matrix protein 1; Secretory component p85", "protein_names_refseq": "extracellular matrix protein 1 isoform 1 precursor; secretory component p85", "tax_id": 10090, "disease": "lipoid proteinosis (Disease Ontology:DOID:14498)", "pathway": " (mmu:13601); (R-MMU-114608)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11165938;16170054;21750661;31219806;34428180;37828378;38402239;38849014;39470347;7608209", "class_list": "", "function": "Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions. Publication Status: Online-Only, [RefSeq, PubMed]; Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9884, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Q5", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005134 interleukin-2 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0010466 negative regulation of peptidase activity;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61508-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149L6-1", "uniprot_id": [ { "id": "DJB14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149L6", "type": "external" } ], "mass": 42326.0, "length": 379, "protein_name": "DnaJ homolog subfamily B member 14", "gene_name": "Dnajb14", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 14", "refseq_ac": [ { "id": "NP_001028327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028327", "type": "external" } ], "gene_names_uniprotkb": "Dnajb14", "gene_names_refseq": "5730496F10Rik; Dnajb14", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 14", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 14; dnaJ homolog subfamily B member 14", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:70604)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;21750661;23018488", "class_list": "", "function": "Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear., [UniProtKB, UniProtKB]; Compared with DNAJB12 mRNA that was widely expressed in mouse tissues, DNAJB14 mRNA was expressed more weakly, being most abundant in testis, implying its specific role in this tissue., [RefSeq, PubMed]; Dnajb14 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU54;Q3UTE5", "ec_number_list": [], "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0071218 cellular response to misfolded protein;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q149L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8P0-1", "uniprot_id": [ { "id": "GCP6_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8P0", "type": "external" } ], "mass": 197192.0, "length": 1769, "protein_name": "Gamma-tubulin complex component 6", "gene_name": "Tubgcp6", "organism": "Mouse", "refseq_name": "gamma-tubulin complex component 6", "refseq_ac": [ { "id": "NP_001156791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156791", "type": "external" } ], "gene_names_uniprotkb": "Tubgcp6; Kiaa1669", "gene_names_refseq": "D430023H11; GCP-6; Tubgcp6; mKIAA1669", "protein_names_uniprotkb": "Gamma-tubulin complex component 6; GCP-6", "protein_names_refseq": "gamma-tubulin complex component 6; tubulin, gamma complex associated protein 6", "tax_id": 10090, "disease": "microcephaly and chorioretinopathy 1 (Disease Ontology:DOID:0080105)", "pathway": " (mmu:328580); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;25428506;31219806;32782141;34203471;34428180;36210013", "class_list": "", "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB]; Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation., [UniProtKB, UniProtKB, UniProtKB]; Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFC6;Q6ZPK3;Q8BWI2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0000930 gamma-tubulin complex;GO:0000931 gamma-tubulin ring complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "G5E8P0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0Q1-1", "uniprot_id": [ { "id": "DYH12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0Q1", "type": "external" } ], "mass": 356231.0, "length": 3086, "protein_name": "Dynein axonemal heavy chain 12", "gene_name": "Dnah12", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnah12; Dnah12l; Dnah7l; Dnahc12; Dnahc7l", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 12; Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 7-like protein; Ciliary dynein heavy chain 12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;34418053;39071892;40146200", "class_list": "", "function": "Involved in spermiogenesis. Plays a role in the proper organization of axoneme in sperm flagella, but not in cilia, by recruiting DNAH1 and DNALI1 to flagellum., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVT4;Q8VHS7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0036156 inner dynein arm;GO:0097729 9+2 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0007286 spermatid development;GO:0016567 protein ubiquitination;GO:0007288 sperm axoneme assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V0Q1-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09163-1", "uniprot_id": [ { "id": "DLK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09163", "type": "external" } ], "mass": 41320.0, "length": 385, "protein_name": "Protein delta homolog 1", "gene_name": "Dlk1", "organism": "Mouse", "refseq_name": "protein delta homolog 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034182", "type": "external" } ], "gene_names_uniprotkb": "Dlk1; Dlk; Pref1; Scp-1", "gene_names_refseq": "DLK-1; Dlk1; DlkI; FA1; Ly107; Peg9; SCP1; ZOG; pG2; pref-1", "protein_names_uniprotkb": "Protein delta homolog 1; Adipocyte differentiation inhibitor protein; DLK-1; Preadipocyte factor 1; Pref-1", "protein_names_refseq": "adipocyte differentiation inhibitor protein; delta-like 1 homolog; fetal antigen 1; preadipocyte factor 1; protein delta homolog 1 isoform 1 precursor; protein delta homolog 1; stromal cell derived protein 1", "tax_id": 10090, "disease": "biliary atresia (Disease Ontology:DOID:13608); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:13386)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10996796;11168589;17320102;21750661;7519443;7711066;8095043;8500166;9118998", "class_list": "", "function": "Dlk1 gene, like the human ortholog, is imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Meg3/Gtl2 and Dlk1/Peg9 genes are imprinted, with reciprocal expression from the maternal and paternal alleles, respectively., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q07645;Q62208", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0035264 multicellular organism growth;GO:0045780 positive regulation of bone resorption;GO:0001819 positive regulation of cytokine production;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q09163-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAM9-1", "uniprot_id": [ { "id": "FANK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAM9", "type": "external" } ], "mass": 38260.0, "length": 344, "protein_name": "Fibronectin type 3 and ankyrin repeat domains 1 protein", "gene_name": "Fank1", "organism": "Mouse", "refseq_name": "fibronectin type 3 and ankyrin repeat domains 1 protein isoform 1", "refseq_ac": [ { "id": "NP_080126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080126", "type": "external" } ], "gene_names_uniprotkb": "Fank1", "gene_names_refseq": "1700007B22Rik; FANK1S; Fank1", "protein_names_uniprotkb": "Fibronectin type 3 and ankyrin repeat domains 1 protein; GSG1; Germ cell-specific gene 1 protein", "protein_names_refseq": "GSG1; fibronectin type 3 and ankyrin repeat domains 1 protein isoform 1; fibronectin type 3 and ankyrin repeat domains 1 protein; germ cell-specific 1; germ cell-specific gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66930)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15803458;17604233;20173027;21750661;27914912", "class_list": "", "function": "FANK1 may have a role in regulating gene expression in the transition from the meiotic phase to the haploid phase during spermatogenesis, [RefSeq, PubMed]; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUA7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AUU0-1", "uniprot_id": [ { "id": "METL8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AUU0", "type": "external" } ], "mass": 31670.0, "length": 281, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial", "gene_name": "Mettl8", "organism": "Mouse", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial isoform b", "refseq_ac": [ { "id": "NP_001103982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982", "type": "external" } ], "gene_names_uniprotkb": "Mettl8; Tip", "gene_names_refseq": "Mettl8; Tip", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial; 2.1.1.-; Methyltransferase-like protein 8; Tension-induced/inhibited protein; mRNA N(3)-methylcytidine methyltransferase METTL8", "protein_names_refseq": "mRNA N(3)-methylcytidine methyltransferase METTL8; methyltransferase like 8; methyltransferase-like protein 8; tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial isoform b; tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial; tension induced/inhibited protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228019)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15992539;18710950;21750661;28655767;29706498", "class_list": "", "function": "METTL8 prohibits the activation of JNK signaling and enhances the differentiation of mouse ESCs. Collectively, our study uncovers a STAT3 target, Mettl8, which regulates mouse ESC differentiation via JNK signaling., [RefSeq, PubMed]; Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (By similarity). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (By similarity). N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (By similarity). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (By similarity)., [UniProtKB, UniProtKB, PubMed]; Overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression., [UniProtKB, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, UniProtKB]; Stimulates adipogenesis., [UniProtKB, PubMed]; TIP-6 was identified as a new member of the adipogenic cascade., [RefSeq, PubMed]; This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUU3;Q2XV35;Q2XV36;Q4FCR9;Q4FCS0;Q6PEN9;Q99KI7", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004402 histone acetyltransferase activity;GO:0008174 mRNA methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0045444 fat cell differentiation;GO:0007519 skeletal muscle tissue development;GO:0070131 positive regulation of mitochondrial translation;GO:0070900 mitochondrial tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AUU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHE1-1", "uniprot_id": [ { "id": "GEMI8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHE1", "type": "external" } ], "mass": 28396.0, "length": 238, "protein_name": "Gem-associated protein 8", "gene_name": "Gemin8", "organism": "Mouse", "refseq_name": "gem-associated protein 8 isoform 1", "refseq_ac": [ { "id": "NP_001297651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297651", "type": "external" } ], "gene_names_uniprotkb": "Gemin8; Fam51a1", "gene_names_refseq": "B130034M20Rik; B930082C09Rik; Gemin8; gemin-8", "protein_names_uniprotkb": "Gem-associated protein 8; Gemin-8; Protein FAM51A1", "protein_names_refseq": "gem-associated protein 8 isoform 1; gem-associated protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:237221); (R-MMU-191859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16434402;17023415;21750661", "class_list": "", "function": "Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway, [RefSeq, PubMed]; Gemin8 is a novel integral component of the SMN complex, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVP4;Q3TUT1;Q8R3W9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BHE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07646-1", "uniprot_id": [ { "id": "MEST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07646", "type": "external" } ], "mass": 38907.0, "length": 335, "protein_name": "Mesoderm-specific transcript protein", "gene_name": "Mest", "organism": "Mouse", "refseq_name": "mesoderm-specific transcript protein isoform 1", "refseq_ac": [ { "id": "NP_001239221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239221", "type": "external" } ], "gene_names_uniprotkb": "Mest; 121a; Peg1", "gene_names_refseq": "Mest; Peg1", "protein_names_uniprotkb": "Mesoderm-specific transcript protein; 3.-.-.-; Paternally-expressed gene 1 protein", "protein_names_refseq": "mesoderm-specific transcript protein isoform 1; mesoderm-specific transcript protein; paternally-expressed gene 1 protein", "tax_id": 10090, "disease": "Barth syndrome (Disease Ontology:DOID:0050476)", "pathway": " (mmu:17294)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12095916;18644838;21375506;21750661;25428506;28133444;28501506;29058774;7550314;9302270", "class_list": "", "function": "Mest/Peg1 gene is imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q792T8;Q8BS88;Q8K463;Q99KT5", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0032526 response to retinoic acid;GO:0045444 fat cell differentiation;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0010883 regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07646-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K214-1", "uniprot_id": [ { "id": "SCMH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K214", "type": "external" } ], "mass": 78669.0, "length": 706, "protein_name": "Polycomb protein SCMH1", "gene_name": "Scmh1", "organism": "Mouse", "refseq_name": "polycomb protein SCMH1 isoform 2", "refseq_ac": [ { "id": "NP_001153102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153102", "type": "external" } ], "gene_names_uniprotkb": "Scmh1", "gene_names_refseq": "Scmh1; Scml1; Scml3", "protein_names_uniprotkb": "Polycomb protein SCMH1; Sex comb on midleg homolog 1", "protein_names_refseq": "polycomb protein SCMH1 isoform 2; polycomb protein SCMH1; sex comb on midleg 1; sex comb on midleg homolog 1; sex comb on midleg-like 1; sex comb on midleg-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:29871); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10653359;21750661;23207902;34203471;34428180;36162459;36210013", "class_list": "", "function": "Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes., [UniProtKB]; CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling axis to promote diabetes-induced retinal epithelial-mesenchymal transition., [RefSeq, PubMed]; Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AS51;Q9JME0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0010369 chromocenter", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URY2-1", "uniprot_id": [ { "id": "GEMC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URY2", "type": "external" } ], "mass": 37758.0, "length": 333, "protein_name": "Geminin coiled-coil domain-containing protein 1", "gene_name": "Gmnc", "organism": "Mouse", "refseq_name": "geminin coiled-coil domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001013783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013783", "type": "external" } ], "gene_names_uniprotkb": "Gmnc; Gemc1; Gm606", "gene_names_refseq": "Gemc1; Gm1778; Gm606; Gmnc", "protein_names_uniprotkb": "Geminin coiled-coil domain-containing protein 1", "protein_names_refseq": "geminin coiled-coil domain-containing protein 1 isoform 1; geminin coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239789)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26395491;26882546;26933123", "class_list": "", "function": "GemC1 directly transactivates the promoters of MCIDAS and FOXJ1., [RefSeq, PubMed]; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity)., [UniProtKB]; Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche., [RefSeq, PubMed]; The authors found that GEMC1-deficient mice are growth impaired, develop hydrocephaly with a high penetrance, and are infertile, due to defects in the formation of multiciliated cells in the brain, respiratory tract, and germline., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUK3;Q5RJG4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:1903251 multi-ciliated epithelial cell differentiation;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3URY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51807-1", "uniprot_id": [ { "id": "DYLT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P51807", "type": "external" } ], "mass": 12483.0, "length": 113, "protein_name": "Dynein light chain Tctex-type 1", "gene_name": "Dynlt1a; Dynlt1", "organism": "Mouse", "refseq_name": "dynein light chain Tctex-type 1A", "refseq_ac": [ { "id": "NP_001160101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160101", "type": "external" } ], "gene_names_uniprotkb": "Dynlt1a; Dynlt1; Tctel1; Tctex-1; Tctex1", "gene_names_refseq": "AGS2; Dynlt1a; Dynlt1; Tctel1; Tctex-1; Tctex1", "protein_names_uniprotkb": "Dynein light chain Tctex-type 1; AGS2; Activator of G protein signaling 2; T-complex testis-specific protein 1; TCTEX-1", "protein_names_refseq": "Activator of G-protein signaling 2; Dynein light chain Tctex-type 1; T-complex testis-specific protein 1; dynein light chain Tctex-type 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040531); (mmu:100040563); (mmu:100310872); (mmu:21648); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10559191;11148215;11278908;19448628;21750661;2570638;27502274;30060180;9490726", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility., [UniProtKB, PubMed, UniProtKB]; Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8S6", "ec_number_list": [], "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005874 microtubule;GO:0030426 growth cone", "go_biological_process": "GO:0007399 nervous system development;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0000132 establishment of mitotic spindle orientation;GO:0050768 negative regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P51807-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CDU5-1", "uniprot_id": [ { "id": "EFHB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CDU5", "type": "external" } ], "mass": 95743.0, "length": 853, "protein_name": "EF-hand domain-containing family member B", "gene_name": "Efhb", "organism": "Mouse", "refseq_name": "EF-hand domain-containing family member B", "refseq_ac": [ { "id": "NP_766085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766085", "type": "external" } ], "gene_names_uniprotkb": "Efhb; Cfap21", "gene_names_refseq": "4921525D22Rik; Efhb", "protein_names_uniprotkb": "EF-hand domain-containing family member B; Cilia- and flagella-associated protein 21", "protein_names_refseq": "EF-hand domain-containing family member B; cilia- and flagella-associated protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:211482)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSG9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0030317 flagellated sperm motility;GO:0032091 negative regulation of protein binding;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CDU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20863-1", "uniprot_id": [ { "id": "GDF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P20863", "type": "external" } ], "mass": 38660.0, "length": 357, "protein_name": "Embryonic growth/differentiation factor 1", "gene_name": "Gdf1", "organism": "Mouse", "refseq_name": "embryonic growth/differentiation factor 1 precursor", "refseq_ac": [ { "id": "NP_001156754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156754", "type": "external" } ], "gene_names_uniprotkb": "Gdf1; Gdf-1", "gene_names_refseq": "Gdf-1; Gdf1", "protein_names_uniprotkb": "Embryonic growth/differentiation factor 1; GDF-1", "protein_names_refseq": "embryonic growth/differentiation factor 1 precursor; embryonic growth/differentiation factor 1", "tax_id": 10090, "disease": "multiple types of congenital heart defects 6 (Disease Ontology:DOID:0060772); annular pancreas (Disease Ontology:DOID:0060850); right atrial isomerism (Disease Ontology:DOID:0060856); dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital heart disease (Disease Ontology:DOID:1682); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:14559)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1704486;2034669;26212015;38491289", "class_list": "", "function": "Epigenetic silencing of GDF1 abrogates the growth-inhibitory SMAD signaling and renders proliferation advantage to gastric epithelial cells during carcinogenesis, [RefSeq, PubMed]; GDF1 ameliorates cognitive impairment induced by hearing loss., [RefSeq, PubMed]; May mediate cell differentiation events during embryonic development., [UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXH1", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0030509 BMP signaling pathway;GO:0007492 endoderm development;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20863-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61090-1", "uniprot_id": [ { "id": "FZD7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61090", "type": "external" } ], "mass": 63733.0, "length": 572, "protein_name": "Frizzled-7", "gene_name": "Fzd7", "organism": "Mouse", "refseq_name": "frizzled-7 precursor", "refseq_ac": [ { "id": "NP_032083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032083", "type": "external" } ], "gene_names_uniprotkb": "Fzd7", "gene_names_refseq": "Fz7; Fzd7", "protein_names_uniprotkb": "Frizzled-7; Fz-7; mFz7", "protein_names_refseq": "frizzled homolog 7; frizzled-7 precursor; frizzled-7; fz-7; mFz7", "tax_id": 10090, "disease": "nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:14369); (R-MMU-4086400); (R-MMU-4608870)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10097073;10395542;15195140;15353129;34667113;36691900;38071893;8626800", "class_list": "", "function": "A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models., [RefSeq, PubMed]; Bioinformatics analysis and experimental validation reveal the anti-ferroptosis effect of FZD7 in acute kidney injury., [RefSeq, PubMed]; Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine., [RefSeq, PubMed]; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G proteins by CCDC88C and triggering of non-canonical Wnt responses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X953", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005109 frizzled binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0034446 substrate adhesion-dependent cell spreading;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKD8-1", "uniprot_id": [ { "id": "MFA1A_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKD8", "type": "external" } ], "mass": 51954.0, "length": 439, "protein_name": "Microfibrillar-associated protein 1A", "gene_name": "Mfap1a", "organism": "Mouse", "refseq_name": "microfibrillar-associated protein 1B", "refseq_ac": [ { "id": "NP_001075444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075444", "type": "external" } ], "gene_names_uniprotkb": "Mfap1a", "gene_names_refseq": "Mfap1a; Mfap1b", "protein_names_uniprotkb": "Microfibrillar-associated protein 1A; Spliceosome B complex protein MFAP1A", "protein_names_refseq": "Microfibrillar-associated protein 1A; Spliceosome B complex protein MFAP1A; microfibrillar-associated protein 1B; microfibrillar-associated protein 1; spliceosome B complex protein MFAP1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100034361); (mmu:67532); (R-MMU-72163)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;19131326;19144319;21183079;34428180;35820727", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU29;Q8CCL1;Q9CQU1;Q9CSJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "C0HKD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21447-1", "uniprot_id": [ { "id": "MDR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P21447", "type": "external" } ], "mass": 140647.0, "length": 1276, "protein_name": "ATP-dependent translocase ABCB1", "gene_name": "Abcb1a", "organism": "Mouse", "refseq_name": "ATP-dependent translocase ABCB1", "refseq_ac": [ { "id": "NP_035206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035206", "type": "external" } ], "gene_names_uniprotkb": "Abcb1a; Abcb4; Mdr1a; Mdr3; Pgy-3; Pgy3", "gene_names_refseq": "Abcb1a; Abcb4; Evi32; Mdr1a; Mdr3; P-gp; Pgp; Pgy-3; Pgy3; mdr-3", "protein_names_uniprotkb": "ATP-dependent translocase ABCB1; 7.6.2.1; 7.6.2.2; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 1A; Multidrug resistance protein 3; P-glycoprotein 3; Phospholipid transporter ABCB1", "protein_names_refseq": "ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 1A; ATP-dependent translocase ABCB1; P-glycoprotein 3; ecotropic viral integration site 32; multi-drug resistance 3; multidrug resistance protein 3; multiple drug resistant 1a; phospholipid transporter ABCB1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); cystic fibrosis (Disease Ontology:DOID:1485); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18671); (R-MMU-382556); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18299400;19325113;1969610;1972547;21952136;2473069;29187734;33300544;34428180;35820727;36215093;36283621;8898203", "class_list": "", "function": "Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex., [RefSeq, PubMed]; Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]., [RefSeq]; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 34, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5I1Y5", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0000086 G2/M transition of mitotic cell cycle;GO:0035640 exploration behavior;GO:0045332 phospholipid translocation;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P21447-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64151-1", "uniprot_id": [ { "id": "SEM4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64151", "type": "external" } ], "mass": 92557.0, "length": 834, "protein_name": "Semaphorin-4C", "gene_name": "Sema4c", "organism": "Mouse", "refseq_name": "semaphorin-4C precursor", "refseq_ac": [ { "id": "NP_001119519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119519", "type": "external" } ], "gene_names_uniprotkb": "Sema4c; S4c; Semacl1; Semai", "gene_names_refseq": "M-Sema F; Sema4c; Semacl1; Semaf; Semai; sema I", "protein_names_uniprotkb": "Semaphorin-4C; M-Sema F; Sema I; Semaphorin I; Semaphorin-C-like 1", "protein_names_refseq": "semaphorin I; semaphorin-4C precursor; semaphorin-4C; semaphorin-C-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20353)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10318831;11134026;11162505;15811348;17498836;17554007;21122816;21750661;31219806;34428180;36892447;7656991", "class_list": "", "function": "Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement., [RefSeq, PubMed]; This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030672 synaptic vesicle membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0001843 neural tube closure;GO:0050919 negative chemotaxis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q64151-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49660-1", "uniprot_id": [ { "id": "SSR4_MOUSE", "url": "https://www.uniprot.org/uniprot/P49660", "type": "external" } ], "mass": 42046.0, "length": 385, "protein_name": "Somatostatin receptor type 4", "gene_name": "Sstr4", "organism": "Mouse", "refseq_name": "somatostatin receptor type 4", "refseq_ac": [ { "id": "NP_033245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033245", "type": "external" } ], "gene_names_uniprotkb": "Sstr4; Smstr4", "gene_names_refseq": "Smstr4; Sstr4; sst4", "protein_names_uniprotkb": "Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R", "protein_names_refseq": "SS-4-R; SS4-R; SS4R; somatostatin receptor type 4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:20608); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11897118;12145348;16670015;21750661;25428506;34884783;38698013;8654950", "class_list": "", "function": "Brain somatostatin receptors 1,2,4 and 5 are up-regulated in somatostatin-deficient mice, and SSTR3 is down-regulated., [RefSeq, PubMed]; Dynamics of somatostatin 4 receptor expression during chronic-stress loading and its potential as a chronic-stress marker. Publication Status: Online-Only, [RefSeq, PubMed]; Reassessment of SST4 Somatostatin Receptor Expression Using SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal Anti-Human SST4 Antibody 7H49L61. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade., [UniProtKB]; The effect of sst2 receptor knockout on sst4 receptor mRNA localization and binding sites throughout the brain has been determined., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ97", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0016477 cell migration;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071385 cellular response to glucocorticoid stimulus;GO:0090238 positive regulation of arachidonate secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49660-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30873-1", "uniprot_id": [ { "id": "SSR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P30873", "type": "external" } ], "mass": 42718.0, "length": 391, "protein_name": "Somatostatin receptor type 1", "gene_name": "Sstr1", "organism": "Mouse", "refseq_name": "somatostatin receptor type 1", "refseq_ac": [ { "id": "NP_033242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033242", "type": "external" } ], "gene_names_uniprotkb": "Sstr1; Smstr1", "gene_names_refseq": "SRIF-2; SS-1-R; SS1-R; SS1R; Smstr-1; Smstr1; Sstr1; sst1", "protein_names_uniprotkb": "Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R", "protein_names_refseq": "somatostatin receptor type 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:20605); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;1346068;31381945;34428180", "class_list": "", "function": "Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins., [UniProtKB]; SSTR5 is primarily expressed and colocalized intracellularly. Activation of SSTR2, 5 and CB1R protected huntingtin-mutant knock-in striatal neurons from quinolinic-acid-induced toxicity. Co-activation of SSTRs and CB1R resulted in loss of protective effects, delayed ERK1/2 phosphorylation and altered receptor complex composition., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis;GO:0030900 forebrain development;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30873-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50652-1", "uniprot_id": [ { "id": "FANCC_MOUSE", "url": "https://www.uniprot.org/uniprot/P50652", "type": "external" } ], "mass": 66979.0, "length": 591, "protein_name": "Fanconi anemia group C protein homolog", "gene_name": "Fancc", "organism": "Mouse", "refseq_name": "Fanconi anemia group C protein homolog isoform 3", "refseq_ac": [ { "id": "NP_001334443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334443", "type": "external" } ], "gene_names_uniprotkb": "Fancc; Facc; Fac", "gene_names_refseq": "Facc; Fancc", "protein_names_uniprotkb": "Fanconi anemia group C protein homolog; Protein FACC", "protein_names_refseq": "Fanconi anemia group C protein homolog isoform 3; fanconi anemia group C protein homolog", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Fanconi anemia complementation group C (Disease Ontology:DOID:0111087); pancytopenia (Disease Ontology:DOID:12450); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:14088); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;25428506;25605945;30084848;32896825;33073500;34428180;7689006", "class_list": "", "function": "DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in physioxia conditions., [RefSeq, PubMed]; Zika virus depletes neural stem cells and evades selective autophagy by suppressing the Fanconi anemia protein FANCC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PXX6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0007281 germ cell development;GO:0019430 removal of superoxide radicals;GO:0048854 brain morphogenesis;GO:0002262 myeloid cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P50652-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2S5-1", "uniprot_id": [ { "id": "FBXL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2S5", "type": "external" } ], "mass": 77894.0, "length": 690, "protein_name": "F-box/LRR-repeat protein 5", "gene_name": "Fbxl5", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 5 isoform A", "refseq_ac": [ { "id": "NP_001153435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153435", "type": "external" } ], "gene_names_uniprotkb": "Fbxl5", "gene_names_refseq": "Fbl4; Fbxl5; Fir4", "protein_names_uniprotkb": "F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5", "protein_names_refseq": "F-box/LRR-repeat protein 5 isoform A; F-box/LRR-repeat protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:242960); (R-MMU-8951664); (R-MMU-917937); (R-MMU-983168)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "20173027;21750661;21907140;23135277;25428506;30084848;30779550;31219806;34428180;35820727;37462473;37743009", "class_list": "", "function": "Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2 (PubMed:21907140, PubMed:23135277). The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquitination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; FBXL5 promotes lipid accumulation in alcoholic fatty liver disease by promoting the ubiquitination and degradation of TFEB., [RefSeq, PubMed]; Role of FBXL5 in redox homeostasis and spindle assembly during oocyte maturation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14CG1;Q3TAK6;Q3TWC9;Q3UC66;Q80XI5;Q8BGF5;Q8BNL3;Q8C3Q8", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051536 iron-sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0016567 protein ubiquitination;GO:0045732 positive regulation of protein catabolic process;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8C2S5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USJ8-1", "uniprot_id": [ { "id": "FCSD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USJ8", "type": "external" } ], "mass": 84282.0, "length": 740, "protein_name": "F-BAR and double SH3 domains protein 2", "gene_name": "Fchsd2", "organism": "Mouse", "refseq_name": "F-BAR and double SH3 domains protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001139482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139482", "type": "external" } ], "gene_names_uniprotkb": "Fchsd2; Kiaa0769; Sh3md3", "gene_names_refseq": "Fchsd2; NWK1; Sh3md3; mKIAA0769", "protein_names_uniprotkb": "F-BAR and double SH3 domains protein 2; NWK1; Protein nervous wreck 1; SH3 multiple domains protein 3", "protein_names_refseq": "F-BAR and double SH3 domains protein 2 isoform 2; F-BAR and double SH3 domains protein 2; FCH and double SH3 domains protein 2; SH3 multiple domains 3; SH3 multiple domains protein 3; protein nervous wreck 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:207278)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15067381;17242355;21750661;23437151;23761074;26495903;26567222;26686642;29887380;30016717;30084848;34428180", "class_list": "", "function": "Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (By similarity). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex (PubMed:23437151). Does not promote actin polymerization in the absence of membranes (By similarity)., [UniProtKB, UniProtKB, PubMed]; Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQZ2;Q6P9R0;Q80TS2", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031594 neuromuscular junction;GO:0055037 recycling endosome;GO:0120043 stereocilium shaft", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0015031 protein transport;GO:0061024 membrane organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3USJ8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2Y6-1", "uniprot_id": [ { "id": "FBX25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2Y6", "type": "external" } ], "mass": 41826.0, "length": 357, "protein_name": "F-box only protein 25", "gene_name": "Fbxo25", "organism": "Mouse", "refseq_name": "F-box only protein 25 isoform 2", "refseq_ac": [ { "id": "NP_080061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080061", "type": "external" } ], "gene_names_uniprotkb": "Fbxo25; Fbx25", "gene_names_refseq": "9130015I06Rik; Fbx25; Fbxo25", "protein_names_uniprotkb": "F-box only protein 25", "protein_names_refseq": "F-box only protein 25 isoform 2; F-box only protein 25", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:66822)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16278047;16714087;18287534;21596019;21750661;25725482", "class_list": "", "function": "Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development., [RefSeq, PubMed]; FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy., [RefSeq, PubMed]; MFbx25 shows predominantly neuronal expression and in adult mouse brain, expression is confined to the hippocampus, the cerebral cortex and the Purkinje cell layer, [RefSeq, PubMed]; Our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 transcriptional activity., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8H3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D2Y6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMC8-1", "uniprot_id": [ { "id": "FCSK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMC8", "type": "external" } ], "mass": 119267.0, "length": 1090, "protein_name": "L-fucose kinase", "gene_name": "Fcsk", "organism": "Mouse", "refseq_name": "L-fucose kinase", "refseq_ac": [ { "id": "NP_758487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758487", "type": "external" } ], "gene_names_uniprotkb": "Fcsk; Fuk", "gene_names_refseq": "1110046B12Rik; Fcsk; Fuk", "protein_names_uniprotkb": "L-fucose kinase; 2.7.1.52; Fucokinase", "protein_names_refseq": "L-fucose kinase; fucokinase; mFLJ00241 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:234730); (R-MMU-6787639)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;14686921;21750661;25428506;31219806;34428180;35820727", "class_list": "glycogene", "function": "Cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase, [RefSeq, PubMed]; Has strong fucokinase activity., [UniProtKB, PubMed]; Has very weak fucokinase activity., [UniProtKB, PubMed]; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 59, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSB1;Q8C7W3;Q8CI18", "ec_number_list": [ { "id": "2.7.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.52", "type": "external" } ], "go_molecular_function": "GO:0050201 fucokinase activity;GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0046835 carbohydrate phosphorylation;GO:0042350 GDP-L-fucose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TMC8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZN4-1", "uniprot_id": [ { "id": "FBX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZN4", "type": "external" } ], "mass": 34493.0, "length": 295, "protein_name": "F-box only protein 6", "gene_name": "Fbxo6", "organism": "Mouse", "refseq_name": "F-box only protein 6", "refseq_ac": [ { "id": "NP_001157176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157176", "type": "external" } ], "gene_names_uniprotkb": "Fbxo6; Fbs2; Fbxo6b", "gene_names_refseq": "FBG2; Fbs2; Fbx6b; Fbxo6b; Fbxo6", "protein_names_uniprotkb": "F-box only protein 6; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2", "protein_names_refseq": "F-box only protein 6b; F-box only protein 6; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50762); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10531037;12939278;15723043;17242355;18203720;21183079;21750661;25428506;28135057;32782141;32848054;33300544;34215698;34428180;34678516;35822049;36217277;37633478;40021952;40885482", "class_list": "glycogene", "function": "FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival., [RefSeq, PubMed]; Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD, [RefSeq, PubMed]; Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase., [RefSeq, PubMed]; Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis., [RefSeq, PubMed]; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A7H0;A2A7H2;B2KFL0;B2KFL2;Q3TML5;Q3UCB0", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0006281 DNA repair;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9QZN4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIB5-1", "uniprot_id": [ { "id": "FERM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIB5", "type": "external" } ], "mass": 77800.0, "length": 680, "protein_name": "Fermitin family homolog 2", "gene_name": "Fermt2", "organism": "Mouse", "refseq_name": "fermitin family homolog 2 isoform 3", "refseq_ac": [ { "id": "NP_666166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666166", "type": "external" } ], "gene_names_uniprotkb": "Fermt2; Plekhc1", "gene_names_refseq": "Fermt2; Kindlin-2; Mig2; Plekhc1", "protein_names_uniprotkb": "Fermitin family homolog 2; Kindlin-2; Pleckstrin homology domain-containing family C member 1", "protein_names_refseq": "fermitin family homolog 2 isoform 3; fermitin family homolog 2; mitogen inducible 2; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain-containing family C member 1", "tax_id": 10090, "disease": "Kindler syndrome (Disease Ontology:DOID:0060472); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:218952); (R-MMU-446353); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18174465;18483218;21183079;21378273;21750661;21768292;21952136;28528544;30084848;30779550;34428180;37507081;38346630", "class_list": "", "function": "Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation., [RefSeq, PubMed]; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C542;Q8K035", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CIB5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1K5-1", "uniprot_id": [ { "id": "FZR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1K5", "type": "external" } ], "mass": 54689.0, "length": 493, "protein_name": "Fizzy-related protein homolog", "gene_name": "Fzr1", "organism": "Mouse", "refseq_name": "fizzy-related protein homolog", "refseq_ac": [ { "id": "NP_062731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062731", "type": "external" } ], "gene_names_uniprotkb": "Fzr1; Fyr; Fzr", "gene_names_refseq": "Cdh1; FZR2; FZR; Fyr; Fzr1; HCDH1; HCDH", "protein_names_uniprotkb": "Fizzy-related protein homolog; Cdh1/Hct1 homolog; Fzr", "protein_names_refseq": "cdh1/Hct1 homolog; cell division cycle 20 related 1; fizzy-related protein homolog; fizzy/cell division cycle 20 related 1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 109 (Disease Ontology:DOID:0070378); disease of cellular proliferation (Disease Ontology:DOID:14566)", "pathway": " (mmu:56371); (R-MMU-174084); (R-MMU-174113); (R-MMU-174178); (R-MMU-176407); (R-MMU-176408); (R-MMU-176417); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-69273); (R-MMU-69656); (R-MMU-983168)", "pathway_count": 13, "publication_count": 8, "publication_id_list": "12797865;17242355;21183079;21750661;22014574;34428180;35729193;36548081", "class_list": "", "function": "Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR)., [UniProtKB, UniProtKB]; The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0046105 thymidine biosynthetic process;GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:2000773 negative regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R1K5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921G8-1", "uniprot_id": [ { "id": "GCP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921G8", "type": "external" } ], "mass": 103223.0, "length": 905, "protein_name": "Gamma-tubulin complex component 2", "gene_name": "Tubgcp2", "organism": "Mouse", "refseq_name": "gamma-tubulin complex component 2 isoform a", "refseq_ac": [ { "id": "NP_001272936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272936", "type": "external" } ], "gene_names_uniprotkb": "Tubgcp2; Gcp2", "gene_names_refseq": "1700022B05Rik; Tubgcp2", "protein_names_uniprotkb": "Gamma-tubulin complex component 2; GCP-2", "protein_names_refseq": "GCP-2; gamma-tubulin complex component 2 isoform a; gamma-tubulin complex component 2; tubulin, gamma complex associated protein 2", "tax_id": 10090, "disease": "complex cortical dysplasia with other brain malformations 15 (Disease Ontology:DOID:0081266)", "pathway": " (mmu:74237); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity). Plays a role in neuronal migration (By similarity)., [UniProtKB, UniProtKB]; Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E859", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0007420 brain development;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q921G8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UVK0-1", "uniprot_id": [ { "id": "ERMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UVK0", "type": "external" } ], "mass": 100148.0, "length": 898, "protein_name": "Endoplasmic reticulum metallopeptidase 1", "gene_name": "Ermp1", "organism": "Mouse", "refseq_name": "endoplasmic reticulum metallopeptidase 1 isoform 1", "refseq_ac": [ { "id": "NP_001074682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074682", "type": "external" } ], "gene_names_uniprotkb": "Ermp1; D19Wsu12e; Fxna; Kiaa1815", "gene_names_refseq": "D19Ertd410e; D19Wsu12e; Ermp1; Fxna; b2b2633Clo; mKIAA1815", "protein_names_uniprotkb": "Endoplasmic reticulum metallopeptidase 1; 3.4.-.-; Felix-ina", "protein_names_refseq": "aminopeptidase Fxna; endoplasmic reticulum metallopeptidase 1 isoform 1; felix-ina", "tax_id": 10090, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:226090)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17267443;21750661;25428506;30084848;30899004;31219806;34428180;40997131", "class_list": "", "function": "Functional analysis of the rat Fxna ortholog., [RefSeq, PubMed]; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RXD6;Q6ZPH9;Q8BIW0;Q8BYX7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006508 proteolysis;GO:0034599 cellular response to oxidative stress;GO:0001541 ovarian follicle development;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UVK0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C088-1", "uniprot_id": [ { "id": "EGFEM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C088", "type": "external" } ], "mass": 65021.0, "length": 590, "protein_name": "EGF-like and EMI domain-containing protein 1", "gene_name": "Egfem1", "organism": "Mouse", "refseq_name": "EGF-like and EMI domain-containing protein 1 isoform b precursor", "refseq_ac": [ { "id": "NP_001161220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161220", "type": "external" } ], "gene_names_uniprotkb": "Egfem1", "gene_names_refseq": "6130401L20Rik; Efcab11; Egfem1", "protein_names_uniprotkb": "EGF-like and EMI domain-containing protein 1", "protein_names_refseq": "EF-hand calcium binding domain 11; EGF-like and EMI domain-containing protein 1 isoform b precursor; EGF-like and EMI domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75740)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZCE8;Q149G1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D0QMC3-1", "uniprot_id": [ { "id": "MNDAL_MOUSE", "url": "https://www.uniprot.org/uniprot/D0QMC3", "type": "external" } ], "mass": 60526.0, "length": 538, "protein_name": "Myeloid cell nuclear differentiation antigen-like protein", "gene_name": "Mndal", "organism": "Mouse", "refseq_name": "myeloid cell nuclear differentiation antigen-like protein isoform 1", "refseq_ac": [ { "id": "NP_001164324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164324", "type": "external" } ], "gene_names_uniprotkb": "Mndal", "gene_names_refseq": "100040462; Gm2785; Ifi212; Mndal", "protein_names_uniprotkb": "Myeloid cell nuclear differentiation antigen-like protein", "protein_names_refseq": "myeloid cell nuclear differentiation antigen-like protein isoform 1; myeloid cell nuclear differentiation antigen-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040462); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19144319;19654412;21750661;25428506;26495903;34428180", "class_list": "", "function": "Mndal acts as a tumor suppressor and displays haploinsufficiency, [RefSeq, PubMed]; Suppresses cell growth when expressed ectopically., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D0QMC4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D0QMC3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXR1-1", "uniprot_id": [ { "id": "DHRS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXR1", "type": "external" } ], "mass": 38167.0, "length": 338, "protein_name": "Dehydrogenase/reductase SDR family member 7", "gene_name": "Dhrs7", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 7 precursor", "refseq_ac": [ { "id": "NP_079798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079798", "type": "external" } ], "gene_names_uniprotkb": "Dhrs7; Retsdr4", "gene_names_refseq": "2310016E22Rik; 5730564L20Rik; Dhrs7; Retdsr4; Retsdr4", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 7; 1.1.1.-; Protein SDR34C1; Retinal short-chain dehydrogenase/reductase 4; Short chain dehydrogenase/reductase family 34C member 1; retSDR4", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7; dehydrogenase/reductase SDR family member 7 precursor; retinal short-chain dehydrogenase/reductase 4; short chain dehydrogenase/reductase family 34C member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66375)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22872234;31219806;36210013;36852467", "class_list": "", "function": "NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CXR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60584-1", "uniprot_id": [ { "id": "FBXW2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60584", "type": "external" } ], "mass": 47896.0, "length": 422, "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "Fbxw2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fbxw2", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 2; F-box and WD-40 domain-containing protein 2; Protein MD6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10531037;1296816;21750661", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PXP3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60584-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GUQ1-1", "uniprot_id": [ { "id": "EGFL8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GUQ1", "type": "external" } ], "mass": 32066.0, "length": 293, "protein_name": "Epidermal growth factor-like protein 8", "gene_name": "Egfl8", "organism": "Mouse", "refseq_name": "epidermal growth factor-like protein 8 precursor", "refseq_ac": [ { "id": "NP_690886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690886", "type": "external" } ], "gene_names_uniprotkb": "Egfl8; Ng3", "gene_names_refseq": "Egfl8; Ng3", "protein_names_uniprotkb": "Epidermal growth factor-like protein 8; EGF-like protein 8", "protein_names_refseq": "EGF-like protein 8; epidermal growth factor-like protein 8 precursor; epidermal growth factor-like protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:81701)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14656967;15162510;21750661;26096343;33448309", "class_list": "", "function": "Descriptive and functional characterization of epidermal growth factorlike domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks., [RefSeq, PubMed]; Mouse EGFL8 encodes a protein of 293 amino acids with two EGFL domains, an Emilin-like domain and a Ca(2+)-binding EGFL domain, which has a molecular mass of 32 kDa., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35447;Q3UFB4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6GUQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9T0-1", "uniprot_id": [ { "id": "DYDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9T0", "type": "external" } ], "mass": 20494.0, "length": 175, "protein_name": "DPY30 domain-containing protein 1", "gene_name": "Dydc1", "organism": "Mouse", "refseq_name": "DPY30 domain-containing protein 1", "refseq_ac": [ { "id": "NP_081370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081370", "type": "external" } ], "gene_names_uniprotkb": "Dydc1", "gene_names_refseq": "1700029M23Rik; Dydc1", "protein_names_uniprotkb": "DPY30 domain-containing protein 1", "protein_names_refseq": "DPY30 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69496)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19545932;21750661;36417862", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:36417862). Plays a crucial role during acrosome biogenesis (PubMed:19545932)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8U6;Q810Q6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9T0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UN58-1", "uniprot_id": [ { "id": "FAP20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UN58", "type": "external" } ], "mass": 20038.0, "length": 186, "protein_name": "Fanconi anemia core complex-associated protein 20", "gene_name": "Faap20", "organism": "Mouse", "refseq_name": "Fanconi anemia core complex-associated protein 20 isoform a", "refseq_ac": [ { "id": "NP_001177374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177374", "type": "external" } ], "gene_names_uniprotkb": "Faap20; 2610002J02Rik", "gene_names_refseq": "2610002J02Rik; Faap20", "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa", "protein_names_refseq": "FANCA-associated protein of 20 kDa; Fanconi anemia core complex-associated protein 20 isoform a; Fanconi anemia-associated protein of 20 kDa; likely orthologue of H. sapiens chromosome 1 open reading frame 86 (C1orf86)", "tax_id": 10090, "disease": "", "pathway": " (mmu:67513); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADD8;Q0VG17", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0030054 cell junction;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UN58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBL2-1", "uniprot_id": [ { "id": "GDAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBL2", "type": "external" } ], "mass": 56269.0, "length": 498, "protein_name": "Ganglioside-induced differentiation-associated protein 2", "gene_name": "Gdap2", "organism": "Mouse", "refseq_name": "ganglioside-induced differentiation-associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_034399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034399", "type": "external" } ], "gene_names_uniprotkb": "Gdap2", "gene_names_refseq": "D3Ertd801e; Gdap2", "protein_names_uniprotkb": "Ganglioside-induced differentiation-associated protein 2", "protein_names_refseq": "ganglioside-induced differentiation-associated protein 2 isoform 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 27 (Disease Ontology:DOID:0111616)", "pathway": " (mmu:14547)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10217254;21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88742;Q8C468", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DBL2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZW7-1", "uniprot_id": [ { "id": "EF2KT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZW7", "type": "external" } ], "mass": 36940.0, "length": 335, "protein_name": "Protein-lysine N-methyltransferase EEF2KMT", "gene_name": "Eef2kmt", "organism": "Mouse", "refseq_name": "protein-lysine N-methyltransferase EEF2KMT", "refseq_ac": [ { "id": "NP_081722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081722", "type": "external" } ], "gene_names_uniprotkb": "Eef2kmt; Fam86a; Fam86", "gene_names_refseq": "5730409G15Rik; Eef2kmt; Fam86a; Fam86; eEF2-KMT", "protein_names_uniprotkb": "Protein-lysine N-methyltransferase EEF2KMT; 2.1.1.-; eEF2-KMT; eEF2-lysine methyltransferase", "protein_names_refseq": "eEF2-lysine methyltransferase; family with sequence similarity 86; protein FAM86A; protein-lysine N-methyltransferase EEF2KMT; putative protein N-methyltransferase FAM86A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70511); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;34428180", "class_list": "", "function": "Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQL2;Q80XE2;Q9CS89", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity;GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0018023 peptidyl-lysine trimethylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UZW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08912-1", "uniprot_id": [ { "id": "GALT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08912", "type": "external" } ], "mass": 64255.0, "length": 559, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 1", "gene_name": "Galnt1", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 1", "refseq_ac": [ { "id": "NP_001153876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153876", "type": "external" } ], "gene_names_uniprotkb": "Galnt1", "gene_names_refseq": "Galnt1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 1; 2.4.1.41; GalNAc-T1; Polypeptide GalNAc transferase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1; galNAc-T1; polypeptide GalNAc transferase 1; polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1; ppGaNTase-T1; protein-UDP acetylgalactosaminyltransferase 1", "tax_id": 10090, "disease": "heart valve disease (Disease Ontology:DOID:4079)", "pathway": " (mmu:14423); (R-MMU-6811436); (R-MMU-913709)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10037781;12651884;15486088;21750661;26740625;27965094;33300544;9153242", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:10037781, PubMed:9153242). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 33, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKS3;Q7TND1", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 1.9, "record_id": "O08912-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY66-1", "uniprot_id": [ { "id": "GAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY66", "type": "external" } ], "mass": 23474.0, "length": 231, "protein_name": "H/ACA ribonucleoprotein complex subunit 1", "gene_name": "Gar1", "organism": "Mouse", "refseq_name": "H/ACA ribonucleoprotein complex subunit 1", "refseq_ac": [ { "id": "NP_080854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080854", "type": "external" } ], "gene_names_uniprotkb": "Gar1; Nola1", "gene_names_refseq": "C430047J18Rik; Gar1; Nola1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 1; Nucleolar protein family A member 1; snoRNP protein GAR1", "protein_names_refseq": "GAR1 ribonucleoprotein homolog; H/ACA ribonucleoprotein complex subunit 1; H/ACA small nucleolar RNPs; nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68147); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;25428506;31219806;34428180;36210013", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (`psi`) residues may serve to stabilize the conformation of rRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X93;Q8C6C5;Q8VDH0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0001651 dense fibrillar component;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0006364 rRNA processing;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CY66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78JE5-1", "uniprot_id": [ { "id": "FBX22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78JE5", "type": "external" } ], "mass": 44203.0, "length": 402, "protein_name": "F-box only protein 22", "gene_name": "Fbxo22", "organism": "Mouse", "refseq_name": "F-box only protein 22", "refseq_ac": [ { "id": "NP_082325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082325", "type": "external" } ], "gene_names_uniprotkb": "Fbxo22; Fbx22", "gene_names_refseq": "0610033L19Rik; 1600016C16Rik; Fbxo22", "protein_names_uniprotkb": "F-box only protein 22", "protein_names_refseq": "F-box only protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:71999); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21750661;22972877;25428506;25605945;26868148;30084848;30779550;31217475;31219806;34428180;37301536", "class_list": "", "function": "FBXO22 Mediates the NGF/TRKA Signaling Pathway in Bone Metastases in Prostate Cancer., [RefSeq, PubMed]; Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes. Publication Status: Online-Only, [RefSeq, PubMed]; Study present evidence that FBXO22 interacts with and promotes polyubiquitination of LKB1. More intriguingly, FBXO22 mediates Lys-63-linked LKB1 polyubiquitination and inhibits kinase activity of LKB1. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0048742 regulation of skeletal muscle fiber development;GO:0006913 nucleocytoplasmic transport;GO:0000209 protein polyubiquitination;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q78JE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08101-1", "uniprot_id": [ { "id": "FCGR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P08101", "type": "external" } ], "mass": 36695.0, "length": 330, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor II", "gene_name": "Fcgr2b; Fcgr2", "organism": "Mouse", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor", "refseq_ac": [ { "id": "NP_034317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034317", "type": "external" } ], "gene_names_uniprotkb": "Fcgr2b; Fcgr2; Fcgr2b; Ly-17", "gene_names_refseq": "CD32; F630109E10Rik; Fc[g]RII; FcgRII; Fcgr2a; Fcgr2b; Fcgr2; Fcr-2; Fcr-3; Ly-17; Ly-m20; LyM-1; Lym-1; fcRII", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor II; Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Ly-17; Lymphocyte antigen 17", "protein_names_refseq": "Fc gamma RIIB; Fc-gamma-RII; FcgammaRIIB; fc gamma receptor IIB; fc-gamma RII; fc-gamma-RIIB; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor; low affinity immunoglobulin gamma Fc region receptor II-b; low affinity immunoglobulin gamma Fc region receptor II; lymphocyte antigen 17", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); thrombosis (Disease Ontology:DOID:0060903); lupus nephritis (Disease Ontology:DOID:0080162); haemophilus meningitis (Disease Ontology:DOID:0080179); lymphoid leukemia (Disease Ontology:DOID:1037); hemolytic disease of the fetus (Disease Ontology:DOID:1098); factor VIII deficiency (Disease Ontology:DOID:12134); common variable immunodeficiency (Disease Ontology:DOID:12177); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); neutropenia (Disease Ontology:DOID:1227); malaria (Disease Ontology:DOID:12365); temporal arteritis (Disease Ontology:DOID:13375); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); arthus reaction (Disease Ontology:DOID:1556); respiratory system disease (Disease Ontology:DOID:1579); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); epilepsy (Disease Ontology:DOID:1826); atherosclerosis (Disease Ontology:DOID:1936); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); hemolytic anemia (Disease Ontology:DOID:583); lymphopenia (Disease Ontology:DOID:614); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:14130); (R-MMU-198933); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-6798695)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10052594;11035084;11465105;1824594;2138587;21750661;26495903;26740625;28011936;2944118;2946078;2957319;30210494;3024012;34428180;8398981;8537115;8683114;9469421;9973396", "class_list": "", "function": "Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 17, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 36, "disease_count": 39, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P08102;P12316;P97917;Q60938;Q60939;Q60940;Q61170;Q61558", "ec_number_list": [], "go_molecular_function": "GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0016358 dendrite development;GO:0046330 positive regulation of JNK cascade;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:1902950 regulation of dendritic spine maintenance", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "P08101-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYJ7-1", "uniprot_id": [ { "id": "DS13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYJ7", "type": "external" } ], "mass": 22481.0, "length": 198, "protein_name": "Dual specificity protein phosphatase 13B", "gene_name": "Dusp13b", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 13B isoform 2", "refseq_ac": [ { "id": "NP_038877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038877", "type": "external" } ], "gene_names_uniprotkb": "Dusp13b; Dusp13; Gm1203; Tmdp", "gene_names_refseq": "DUSP13A; Dusp13b; Dusp13; Gm1203; LMW-DSP6; MDSP; TMDP; TS-DSP6", "protein_names_uniprotkb": "Dual specificity protein phosphatase 13B; 3.1.3.16; 3.1.3.48; DUSP13B; Dual specificity tyrosine phosphatase TS-DSP6; Testis- and skeletal muscle-specific DSP", "protein_names_refseq": "Dsp13-like protein; dual specificity phosphatase 13; dual specificity protein phosphatase 13B isoform 2; dual specificity protein phosphatase 13B; dual specificity protein phosphatase 13; dual-specificity tyrosine phosphatase TS-DSP6; muscle-restricted DSP; testis and skeletal muscle-specific dual specificity phosphatase; testis- and skeletal muscle-specific DSP", "tax_id": 10090, "disease": "", "pathway": " (mmu:27389)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10585869;15252030;21750661", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB]; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (By similarity). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869)., [UniProtKB, PubMed, UniProtKB]; Expression of both MDSP and TMDP proteins was markedly increased at the 3rd week after birth and continued to increase gradually into adulthood, implying that the physiological functions of both DSPs are specific to the mature/late-developing organs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497R2", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7X3-1", "uniprot_id": [ { "id": "DUS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7X3", "type": "external" } ], "mass": 20472.0, "length": 185, "protein_name": "Dual specificity protein phosphatase 3", "gene_name": "Dusp3", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 3", "refseq_ac": [ { "id": "NP_082483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082483", "type": "external" } ], "gene_names_uniprotkb": "Dusp3", "gene_names_refseq": "2210015O03Rik; 5031436O03Rik; Dusp3; T-DSP11; VHR", "protein_names_uniprotkb": "Dual specificity protein phosphatase 3; 3.1.3.16; 3.1.3.48; T-DSP11; VHR; Vaccinia H1-related phosphatase", "protein_names_refseq": "dual specificity protein phosphatase 3; vaccinia H1-related phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72349); (R-MMU-202670)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16845380;21750661;21921027;34704357;37272465;37865089", "class_list": "", "function": "Dual Specificity Phosphatase 3 (DUSP3) Knockdown Alleviates Acute Myocardial Infarction Damage via Inhibiting Apoptosis and Inflammation., [RefSeq, PubMed]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB, UniProtKB]; Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3, [RefSeq, PubMed]; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0008092 cytoskeletal protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0050922 negative regulation of chemotaxis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D7X3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM2-1", "uniprot_id": [ { "id": "DPOG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZM2", "type": "external" } ], "mass": 51467.0, "length": 459, "protein_name": "DNA polymerase subunit gamma-2", "gene_name": "Polg2", "organism": "Mouse", "refseq_name": "DNA polymerase subunit gamma-2 isoform 1a", "refseq_ac": [ { "id": "NP_056625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056625", "type": "external" } ], "gene_names_uniprotkb": "Polg2; Mtpolb", "gene_names_refseq": "Polg2; mtPolB; p55; polG-beta", "protein_names_uniprotkb": "DNA polymerase subunit gamma-2; DNA polymerase gamma accessory 55 kDa subunit; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta; p55", "protein_names_refseq": "DNA polymerase gamma accessory 55 kDa subunit; DNA polymerase subunit gamma-2 isoform 1a; DNA polymerase subunit gamma-2, mitochondrial; mitochondrial DNA polymerase accessory subunit; mitochondrial polymerase gamma 2", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 16 (Disease Ontology:DOID:0070446); mitochondrial DNA depletion syndrome 16B (Disease Ontology:DOID:0070447); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 (Disease Ontology:DOID:0111525); nephrocalcinosis (Disease Ontology:DOID:12679)", "pathway": " (mmu:50776); (R-MMU-9913635)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10666468;11172710;21750661;23197651;30395686", "class_list": "", "function": "Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA., [UniProtKB, UniProtKB]; Our data indicate that Polg2 function is critical to mammalian embryogenesis and mtDNA replication, and that a single copy of Polg2 is sufficient to sustain life., [RefSeq, PubMed]; Studies have identified a mutant mouse model for inherited renal calcification associated with a Polg2 nonsense mutation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9531, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ARB5;O35614", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003887 DNA-directed DNA polymerase activity;GO:0042802 identical protein binding;GO:0070182 DNA polymerase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0005760 gamma DNA polymerase complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0007005 mitochondrion organization;GO:1900264 positive regulation of DNA-directed DNA polymerase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZM2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50396-1", "uniprot_id": [ { "id": "GDIA_MOUSE", "url": "https://www.uniprot.org/uniprot/P50396", "type": "external" } ], "mass": 50522.0, "length": 447, "protein_name": "Rab GDP dissociation inhibitor alpha", "gene_name": "Gdi1", "organism": "Mouse", "refseq_name": "rab GDP dissociation inhibitor alpha", "refseq_ac": [ { "id": "NP_034403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034403", "type": "external" } ], "gene_names_uniprotkb": "Gdi1; Rabgdia", "gene_names_refseq": "GDIA; GDIalpha; Gdi1", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor alpha; GDI-1; Guanosine diphosphate dissociation inhibitor 1; Rab GDI alpha", "protein_names_refseq": "GDI-1; Rab GDIalpha; guanosine diphosphate (GDP) dissociation inhibitor 1; guanosine diphosphate dissociation inhibitor 1; rab GDI alpha; rab GDP dissociation inhibitor alpha", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 41 (Disease Ontology:DOID:0112058); cancer (Disease Ontology:DOID:162); psychotic disorder (Disease Ontology:DOID:2468)", "pathway": " (mmu:14567); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11027356;19570034;21183079;21750661;25428506;25605945;26495903;26740625;28011936;28057534;33300544;33309713;34428180;37507081;37828378;40684658;7513052", "class_list": "", "function": "Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse., [RefSeq, PubMed]; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes., [UniProtKB, UniProtKB, UniProtKB]; Study used cognitive protocols with high translational validity to human condition that target the functionality of cortico-striatal circuitry such as attention and stimulus selection ability with progressive degree of complexity; showed that that Gdi1-null mice are impaired in attention and associative learning processes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AMA8;Q3TBI9;Q8VHM3;Q91Y71;Q91Z41;Q96CX5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005093 Rab GDP-dissociation inhibitor activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0015031 protein transport;GO:0051592 response to calcium ion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P50396-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640P4-1", "uniprot_id": [ { "id": "GL8D2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640P4", "type": "external" } ], "mass": 39933.0, "length": 349, "protein_name": "Glycosyltransferase 8 domain-containing protein 2", "gene_name": "Glt8d2", "organism": "Mouse", "refseq_name": "glycosyltransferase 8 domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_083378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083378", "type": "external" } ], "gene_names_uniprotkb": "Glt8d2", "gene_names_refseq": "1110021D20Rik; Glt8d2", "protein_names_uniprotkb": "Glycosyltransferase 8 domain-containing protein 2; 2.4.1.-", "protein_names_refseq": "glycosyltransferase 8 domain-containing protein 2 isoform 1; glycosyltransferase 8 domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74782)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D163", "ec_number_list": [], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q640P4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AED3-1", "uniprot_id": [ { "id": "FNDC7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AED3", "type": "external" } ], "mass": 78141.0, "length": 737, "protein_name": "Fibronectin type III domain-containing protein 7", "gene_name": "Fndc7", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 7 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001159437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159437", "type": "external" } ], "gene_names_uniprotkb": "Fndc7", "gene_names_refseq": "E230011A21Rik; Fndc7", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 7", "protein_names_refseq": "fibronectin type III domain-containing protein 7 isoform 2 precursor; fibronectin type III domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:320181)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36210013", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AED1;A2AED2;Q14DI4;Q14DS1;Q3TNR1;Q8BW61;Q8BW83", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AED3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZY2-1", "uniprot_id": [ { "id": "GLCTK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZY2", "type": "external" } ], "mass": 55293.0, "length": 523, "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "organism": "Mouse", "refseq_name": "glycerate kinase", "refseq_ac": [ { "id": "NP_001034675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034675", "type": "external" } ], "gene_names_uniprotkb": "Glyctk", "gene_names_refseq": "6230410P16Rik; C430006L12; Glyctk", "protein_names_uniprotkb": "Glycerate kinase; 2.7.1.31", "protein_names_refseq": "glycerate kinase", "tax_id": 10090, "disease": "D-glyceric aciduria (Disease Ontology:DOID:0111626)", "pathway": " (mmu:235582); (R-MMU-70350)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16753811;19372376;21750661;22029865;23576753;34428180", "class_list": "", "function": "Data show significant evidence of linkages were obtained with NMR signals characterizing the glycerate (LOD10-42) at the mutant glycerate kinase locus, which demonstrate the power of metabolomics to identify the biological function of genetic variants., [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~73%., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNX6;Q8BQL0;Q8C717;Q8C7I3;Q8CI81;Q8K0R7", "ec_number_list": [ { "id": "2.7.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.31", "type": "external" } ], "go_molecular_function": "GO:0008887 glycerate kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006001 fructose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZY2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4Y0-1", "uniprot_id": [ { "id": "FCRL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4Y0", "type": "external" } ], "mass": 37277.0, "length": 343, "protein_name": "Fc receptor-like protein 1", "gene_name": "Fcrl1", "organism": "Mouse", "refseq_name": "Fc receptor-like protein 1 isoform 3 precursor", "refseq_ac": [ { "id": "NP_001129708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129708", "type": "external" } ], "gene_names_uniprotkb": "Fcrl1; Fcrh1; Ifgp1", "gene_names_refseq": "A230020G22Rik; Bxmas1; Bxmh1b; Bxmh1; Fcrh1l; Fcrh1s; Fcrh1; Fcrl1; Ifgp1", "protein_names_uniprotkb": "Fc receptor-like protein 1; BXMAS1-like protein 1; Fc receptor homolog 1; FcR-like protein 1; FcRH1; FcRL1; IFGP family protein 1; mBXMH1; mIFGP1; moFcRH1", "protein_names_refseq": "BXMAS1-like protein 1b; Fc receptor-like protein 1 isoform 3 precursor; Fc receptor-like protein 1; IFGP family protein 1; fc receptor homolog 1; fcR-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229499)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12037601;15302849;21750661;26495903;28011936;31328160;32152506;34697226;35984892", "class_list": "", "function": "May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation (By similarity)., [UniProtKB]; These findings reveal a critical BCR signal-enhancing function of FcRL1 through its intrinsic recruitment to B cell immunological synapses and subsequent recruitment of c-Abl upon BCR cross-linking. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q68SP0;Q7TMH2;Q80WN3;Q8BYS4", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0035591 signaling adaptor activity;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R4Y0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54917-1", "uniprot_id": [ { "id": "E2F6_MOUSE", "url": "https://www.uniprot.org/uniprot/O54917", "type": "external" } ], "mass": 30852.0, "length": 272, "protein_name": "Transcription factor E2F6", "gene_name": "E2f6", "organism": "Mouse", "refseq_name": "transcription factor E2F6", "refseq_ac": [ { "id": "NP_150373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150373", "type": "external" } ], "gene_names_uniprotkb": "E2f6", "gene_names_refseq": "E2F6a; E2F6b; E2f6; EMA", "protein_names_uniprotkb": "Transcription factor E2F6; E2F-6; E2F-binding site-modulating activity protein; EMA", "protein_names_refseq": "E2F-6; E2F-binding site-modulating activity protein; transcription factor E2F6; transcriptional repressor E2F6", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:50496); (R-MMU-8953750)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18667754;21750661;34857746;37178508;39164010;9403682", "class_list": "", "function": "Inhibitor of E2F-dependent transcription (PubMed:9403682). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:18667754, PubMed:9403682). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9403682). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9403682). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (PubMed:18667754). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; MicroRNA-31 regulates TNF-alpha and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6., [RefSeq, PubMed]; Relationship Between Changes in the Expression Levels of miR-134 and E2F6 in Mediating Control of Apoptosis in NMDA-Induced Glaucomatous Mice., [RefSeq, PubMed]; Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K456", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071339 MLL1 complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54917-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFY1-1", "uniprot_id": [ { "id": "FCSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFY1", "type": "external" } ], "mass": 76256.0, "length": 688, "protein_name": "F-BAR and double SH3 domains protein 1", "gene_name": "Fchsd1", "organism": "Mouse", "refseq_name": "F-BAR and double SH3 domains protein 1 isoform 1", "refseq_ac": [ { "id": "NP_783615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783615", "type": "external" } ], "gene_names_uniprotkb": "Fchsd1", "gene_names_refseq": "A030002D08Rik; Fchsd1; NWK2", "protein_names_uniprotkb": "F-BAR and double SH3 domains protein 1; NWK2; Protein nervous wreck 2", "protein_names_refseq": "F-BAR and double SH3 domains protein 1 isoform 1; F-BAR and double SH3 domains protein 1; FCH and double SH3 domains protein 1; protein nervous wreck 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319262)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15067381;21750661;23437151;23761074;26567222;29887380;31219806;34168078", "class_list": "", "function": "Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease., [RefSeq, PubMed]; Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate., [RefSeq, PubMed]; Promotes actin polymerization mediated by SNX9 and WASL., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BV86", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0043204 perikaryon;GO:0055037 recycling endosome;GO:0042995 cell projection", "go_biological_process": "GO:0006954 inflammatory response;GO:0007274 neuromuscular synaptic transmission;GO:0006915 apoptotic process;GO:0051170 import into nucleus;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PFY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D417-1", "uniprot_id": [ { "id": "FBX24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D417", "type": "external" } ], "mass": 65429.0, "length": 589, "protein_name": "F-box only protein 24", "gene_name": "Fbxo24", "organism": "Mouse", "refseq_name": "F-box only protein 24", "refseq_ac": [ { "id": "NP_081984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081984", "type": "external" } ], "gene_names_uniprotkb": "Fbxo24; Fbx24", "gene_names_refseq": "4933422D21Rik; Fbx24; Fbxo24", "protein_names_uniprotkb": "F-box only protein 24", "protein_names_refseq": "F-box only protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:71176)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;38470475;38735474;39039092;39163107;40657752", "class_list": "", "function": "FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility. Publication Status: Online-Only, [RefSeq, PubMed]; FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Publication Status: Online-Only, [RefSeq, PubMed]; FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration., [RefSeq, PubMed]; Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation. Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition (By similarity). Also mediates 'Lys-6'-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis (PubMed:40657752). Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity (PubMed:39039092). In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0006325 chromatin organization;GO:0007005 mitochondrion organization;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D417-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPY5-1", "uniprot_id": [ { "id": "GLBL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPY5", "type": "external" } ], "mass": 72236.0, "length": 636, "protein_name": "Beta-galactosidase-1-like protein 2", "gene_name": "Glb1l2", "organism": "Mouse", "refseq_name": "beta-galactosidase-1-like protein 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001297697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297697", "type": "external" } ], "gene_names_uniprotkb": "Glb1l2", "gene_names_refseq": "Glb1l2", "protein_names_uniprotkb": "Beta-galactosidase-1-like protein 2; 3.2.1.23", "protein_names_refseq": "beta-galactosidase-1-like protein 2 isoform 2 precursor; beta-galactosidase-1-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244757); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;30084848;30779550", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 44, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFT1", "ec_number_list": [ { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" } ], "go_molecular_function": "GO:0004565 beta-galactosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005773 vacuole", "go_biological_process": "GO:0019388 galactose catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UPY5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AYB6-1", "uniprot_id": [ { "id": "MBD5_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AYB6", "type": "external" } ], "mass": 160292.0, "length": 1498, "protein_name": "Methyl-CpG-binding domain protein 5", "gene_name": "Mbd5", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 5 isoform b", "refseq_ac": [ { "id": "NP_001277585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277585", "type": "external" } ], "gene_names_uniprotkb": "Mbd5", "gene_names_refseq": "9430004D19Rik; C030040A15Rik; Gm1630; Mbd5", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 5; Methyl-CpG-binding protein MBD5", "protein_names_refseq": "methyl-CpG-binding domain protein 5 isoform b; methyl-CpG-binding protein MBD5", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder (Disease Ontology:DOID:0060307); autosomal dominant intellectual developmental disorder 1 (Disease Ontology:DOID:0070031)", "pathway": " (mmu:109241); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20700456;21750661;23077600;24750026;25001218;32503625;36997128", "class_list": "", "function": "MBD5 regulates NMDA receptor expression and seizures by inhibiting Stat1 transcription. Erratum:[Neurobiol Dis. 2023 Jun 15;182:106158. doi: 10.1016/j.nbd.2023.106158. PMID: 37244821], [RefSeq, PubMed]; MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1., [RefSeq, PubMed]; Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis, [RefSeq, PubMed]; This study indicates that the Mbd5(+/) (GT) mouse model recapitulates most of the hallmark phenotypes observed in 2q23.1 deletion carriers including abnormal social behavior, cognitive impairment, and motor and craniofacial abnormalities., [RefSeq, PubMed]; Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AYB7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030496 midbody;GO:0005694 chromosome;GO:0010369 chromocenter", "go_biological_process": "GO:0060399 positive regulation of growth hormone receptor signaling pathway;GO:0007399 nervous system development;GO:0040014 regulation of multicellular organism growth;GO:0042593 glucose homeostasis;GO:0050795 regulation of behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1AYB6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW94-1", "uniprot_id": [ { "id": "DYH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW94", "type": "external" } ], "mass": 467777.0, "length": 4083, "protein_name": "Dynein axonemal heavy chain 3", "gene_name": "Dnah3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnah3; Dnahc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 3; Axonemal beta dynein heavy chain 3; Ciliary dynein heavy chain 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:381917)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;38312775;39503742;9373155", "class_list": "", "function": "Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Essential for the assembly and structural organization of the sperm flagellum's axoneme, including its inner dynein arms and accessory components, which are critical for maintaining flagellar integrity and motility (PubMed:39503742, PubMed:38312775)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08829;Q7TT83", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0036156 inner dynein arm;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0007288 sperm axoneme assembly;GO:0036159 inner dynein arm assembly;GO:0007018 microtubule-based movement;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BW94-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC58-1", "uniprot_id": [ { "id": "DRAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC58", "type": "external" } ], "mass": 26201.0, "length": 238, "protein_name": "DNA damage-regulated autophagy modulator protein 1", "gene_name": "Dram1", "organism": "Mouse", "refseq_name": "DNA damage-regulated autophagy modulator protein 1 isoform 1", "refseq_ac": [ { "id": "NP_082154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082154", "type": "external" } ], "gene_names_uniprotkb": "Dram1; Dram", "gene_names_refseq": "1200002N14Rik; Dram1; Dram", "protein_names_uniprotkb": "DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator", "protein_names_refseq": "DNA damage-regulated autophagy modulator protein 1 isoform 1; DNA damage-regulated autophagy modulator protein 1; damage-regulated autophagy modulator", "tax_id": 10090, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:71712)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22082963;25342320;32943616;33184797;34428180;36380631;36980169", "class_list": "", "function": "Balance between autophagy and cell death is maintained by Polycomb-mediated regulation during stem cell differentiation., [RefSeq, PubMed]; DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease., [RefSeq, PubMed]; DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines., [RefSeq, PubMed]; DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; DRAM1 knockdown aggravates OGD/R-induced cell injury. Publication Status: Online-Only, [RefSeq, PubMed]; DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78J26", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006979 response to oxidative stress;GO:0010506 regulation of autophagy;GO:0006915 apoptotic process;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DC58-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPV2-1", "uniprot_id": [ { "id": "DZIP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPV2", "type": "external" } ], "mass": 138021.0, "length": 1204, "protein_name": "E3 ubiquitin-protein ligase DZIP3", "gene_name": "Dzip3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DZIP3 isoform 2", "refseq_ac": [ { "id": "NP_081617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081617", "type": "external" } ], "gene_names_uniprotkb": "Dzip3; Kiaa0675", "gene_names_refseq": "2310047C04Rik; 2A-HUB; 6430549P11Rik; A230104G20; Dzip3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DZIP3; 2.3.2.27; DAZ-interacting protein 3 homolog; RING-type E3 ubiquitin transferase DZIP3", "protein_names_refseq": "DAZ-interacting protein 3 homolog; E3 ubiquitin-protein ligase DZIP3 isoform 2; E3 ubiquitin-protein ligase DZIP3; RING-type E3 ubiquitin transferase DZIP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:224170); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;26568260;34428180", "class_list": "", "function": "Dzip3, the E3 ligase of H2AK119, represses differentiation-inducible genes in mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148V3;Q80TU4;Q8BYK7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TPV2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDW0-1", "uniprot_id": [ { "id": "DX39A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDW0", "type": "external" } ], "mass": 49067.0, "length": 427, "protein_name": "ATP-dependent RNA helicase DDX39A", "gene_name": "Ddx39a", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX39A isoform a", "refseq_ac": [ { "id": "NP_932099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932099", "type": "external" } ], "gene_names_uniprotkb": "Ddx39a; Ddx39", "gene_names_refseq": "2610307C23Rik; BAT1; DDXL; Ddx39a; Ddx39; URH49", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX39A; 3.6.4.13; DEAD box protein 39", "protein_names_refseq": "ATP-dependent RNA helicase DDX39A isoform a; ATP-dependent RNA helicase DDX39A; ATP-dependent RNA helicase DDX39; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39; DEAD box protein 39; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39; UAP56-related helicase, 49 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:68278); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15047853;21750661;21859714;23898070;25428506;30779550;31219806;34203471;39107495;39627609", "class_list": "", "function": "Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA., [UniProtKB, UniProtKB]; Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49, [RefSeq, PubMed]; Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells., [RefSeq, PubMed]; Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of DDX39 in gemcitabine-sensitive KLM1 and -resistant KLM1-R cells was compared., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJV4;Q8C2C2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0002224 toll-like receptor signaling pathway;GO:0000398 mRNA splicing, via spliceosome;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VDW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D291-1", "uniprot_id": [ { "id": "DESI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D291", "type": "external" } ], "mass": 21434.0, "length": 194, "protein_name": "Deubiquitinase DESI2", "gene_name": "Desi2", "organism": "Mouse", "refseq_name": "deubiquitinase DESI2", "refseq_ac": [ { "id": "NP_077244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077244", "type": "external" } ], "gene_names_uniprotkb": "Desi2; Fam152a; Pppde1", "gene_names_refseq": "5830417C01Rik; DeSI-2; Desi2; Fam152a; Pppde1", "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; DeSI-2; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2", "protein_names_refseq": "PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; S-depalmitoylase DESI2; deubiquitinase DESI2; family with sequence similarity 152, member A; palmitoyl protein thioesterase DESI2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78825)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19133312;21553223;21750661;22370726;23567336;31219806;37828378", "class_list": "", "function": "Expression regulation and biological functions of PPPDE1 in development and carcinogenesis., [RefSeq, PubMed]; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of mouse PNAS4 significantly suppressed Lewis lung carcinoma growth and prolonged survival time through induction of tumor cell apoptosis, [RefSeq, PubMed]; PNAS4 was not involved in mice brain development and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUJ4", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D291-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C569-1", "uniprot_id": [ { "id": "F118B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C569", "type": "external" } ], "mass": 39508.0, "length": 351, "protein_name": "Protein FAM118B", "gene_name": "Fam118b", "organism": "Mouse", "refseq_name": "protein FAM118B isoform 1", "refseq_ac": [ { "id": "NP_001273533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273533", "type": "external" } ], "gene_names_uniprotkb": "Fam118b", "gene_names_refseq": "2310022O21Rik; 2700018L24Rik; C030004A17Rik; Fam118b; Ppp4r1l; Sir2l1", "protein_names_uniprotkb": "Protein FAM118B", "protein_names_refseq": "family with sequence similarity 118, member B; protein FAM118B isoform 1; protein FAM118B", "tax_id": 10090, "disease": "", "pathway": " (mmu:109229)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23806337;25428506", "class_list": "", "function": "May play a role in Cajal bodies formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THR7;Q8BNN4;Q8BT26", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0015030 Cajal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C569-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z46-1", "uniprot_id": [ { "id": "DUS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Z46", "type": "external" } ], "mass": 45220.0, "length": 422, "protein_name": "Dual specificity protein phosphatase 7", "gene_name": "Dusp7", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 7", "refseq_ac": [ { "id": "NP_703189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703189", "type": "external" } ], "gene_names_uniprotkb": "Dusp7", "gene_names_refseq": "Dusp7; Mkpx; Pyst2", "protein_names_uniprotkb": "Dual specificity protein phosphatase 7; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:235584); (R-MMU-112409); (R-MMU-202670); (R-MMU-5675221)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "18058922;21750661;27783954;30084848;34428180;35596107;36227898", "class_list": "", "function": "DUSP7 is an essential regulator of multiple steps in oocyte meiosis., [RefSeq, PubMed]; Data show that Dusp7 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development., [RefSeq, PubMed]; Dual Specific Phosphatase 7 Exacerbates Dilated Cardiomyopathy, Heart Failure, and Cardiac Death by Inactivating the ERK1/2 Signaling Pathway., [RefSeq, PubMed]; Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity protein phosphatase (PubMed:27783954). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption (PubMed:27783954). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (PubMed:27783954). May also inactivate PRKCA and/or PRKCG (PubMed:27783954). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (PubMed:27783954)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PVF4;E9QMS8;Q3USH2", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0043407 negative regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91Z46-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3K7-1", "uniprot_id": [ { "id": "GCNT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3K7", "type": "external" } ], "mass": 48580.0, "length": 433, "protein_name": "Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7", "gene_name": "Gcnt7", "organism": "Mouse", "refseq_name": "probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7", "refseq_ac": [ { "id": "NP_001034649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034649", "type": "external" } ], "gene_names_uniprotkb": "Gcnt7", "gene_names_refseq": "A330041C17Rik; Gcnt7; gnt", "protein_names_uniprotkb": "Probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; 2.4.1.-", "protein_names_refseq": "beta 1,6-N-acetylglucosaminyltransferase; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; likely orthologue of H. sapiens chromosome 20 open reading frame 105 (C20orf105); probable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:654821); (R-MMU-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene;glycosyltransferase", "function": "Probable glycosyltransferase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RSZ6;Q3V174", "ec_number_list": [ { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V3K7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09102-1", "uniprot_id": [ { "id": "GCM2_MOUSE", "url": "https://www.uniprot.org/uniprot/O09102", "type": "external" } ], "mass": 56039.0, "length": 504, "protein_name": "Chorion-specific transcription factor GCMb", "gene_name": "Gcm2", "organism": "Mouse", "refseq_name": "chorion-specific transcription factor GCMb", "refseq_ac": [ { "id": "NP_032130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032130", "type": "external" } ], "gene_names_uniprotkb": "Gcm2; Gcmb", "gene_names_refseq": "Gcm-rs1; Gcm1-rs2; Gcm1; Gcm2", "protein_names_uniprotkb": "Chorion-specific transcription factor GCMb; GCM motif protein 2; Glial cells missing homolog 2; mGCMb", "protein_names_refseq": "GCM motif protein 2; chorion-specific transcription factor GCMb; mGCMb", "tax_id": 10090, "disease": "familial isolated hypoparathyroidism 2 (Disease Ontology:DOID:0061151); hypoparathyroidism (Disease Ontology:DOID:11199); hyperparathyroidism (Disease Ontology:DOID:13543); infertility (Disease Ontology:DOID:5223)", "pathway": " (mmu:107889)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;35941210;8962155;9770492", "class_list": "", "function": "Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB03;Q9QWX7;Q9Z289", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060017 parathyroid gland development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09102-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H611-1", "uniprot_id": [ { "id": "MIPEP_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H611", "type": "external" } ], "mass": 80852.0, "length": 711, "protein_name": "Mitochondrial intermediate peptidase", "gene_name": "Mipep", "organism": "Mouse", "refseq_name": "mitochondrial intermediate peptidase precursor", "refseq_ac": [ { "id": "NP_081712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081712", "type": "external" } ], "gene_names_uniprotkb": "Mipep", "gene_names_refseq": "5730405E07Rik; MIP; Mipep", "protein_names_uniprotkb": "Mitochondrial intermediate peptidase; 3.4.24.59; MIP", "protein_names_refseq": "mitochondrial intermediate peptidase precursor", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 31 (Disease Ontology:DOID:0111488); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (mmu:70478)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;29151261", "class_list": "", "function": "Cleaves proteins, imported into the mitochondrion, to their mature size., [UniProtKB]; MIPEP may contribute to the maintenance of mitochondrial quality during caloric restriction (CR) via activation of SIRT3. This novel mechanism of SIRT3 activation through MIPEP facilitates the elucidation of additional molecular pathways of CR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YD79;Q3UJJ3;Q80VA3", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6H611-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K259-1", "uniprot_id": [ { "id": "GIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K259", "type": "external" } ], "mass": 58789.0, "length": 518, "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "Gin1", "organism": "Mouse", "refseq_name": "gypsy retrotransposon integrase-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001297702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297702", "type": "external" } ], "gene_names_uniprotkb": "Gin1; Zh2c2", "gene_names_refseq": "4930429M06Rik; 8430411H10Rik; Gin-1; Gin1; Zh2c2", "protein_names_uniprotkb": "Gypsy retrotransposon integrase-like protein 1; GIN-1; Zinc finger H2C2 domain-containing protein", "protein_names_refseq": "gypsy retrotransposon integrase-like protein 1 isoform 2; gypsy retrotransposon integrase-like protein 1; zinc finger H2C2 domain-containing protein; zinc finger, H2C2 domain containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:252876)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEY8;Q3V2V3;Q8C3X6;Q9CXB6;Q9D5K2", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K259-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16882-1", "uniprot_id": [ { "id": "GHR_MOUSE", "url": "https://www.uniprot.org/uniprot/P16882", "type": "external" } ], "mass": 72783.0, "length": 650, "protein_name": "Growth hormone receptor", "gene_name": "Ghr", "organism": "Mouse", "refseq_name": "growth hormone receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001041643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041643", "type": "external" } ], "gene_names_uniprotkb": "Ghr", "gene_names_refseq": "GHBP; GHR/BP; Ghr", "protein_names_uniprotkb": "Growth hormone receptor; GH receptor; Serum-binding protein; Somatotropin receptor", "protein_names_refseq": "GH receptor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor isoform 2 precursor; growth hormone receptor/binding protein, high molecular weight; growth hormone receptor/binding protein, low molecular weight; somatotropin receptor", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); osteoporosis (Disease Ontology:DOID:11476); osteopetrosis (Disease Ontology:DOID:13533); familial hypercholesterolemia (Disease Ontology:DOID:13810); breast cancer (Disease Ontology:DOID:1612); colonic disease (Disease Ontology:DOID:5353); muscular atrophy (Disease Ontology:DOID:767); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); Laron syndrome (Disease Ontology:DOID:9521); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:14600); (R-MMU-1170546); (R-MMU-982772)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10425445;12379490;21750661;21980433;25428506;2739661;30084848;33109704;3398846;34428180;7894338;7988474", "class_list": "", "function": "Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway., [UniProtKB, UniProtKB]; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P16590;Q61653;Q6DI66;Q80W86;Q8R1M5;Q920Z3;Q9R264", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031623 receptor internalization;GO:0040014 regulation of multicellular organism growth;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P16882-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70428-1", "uniprot_id": [ { "id": "EXT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70428", "type": "external" } ], "mass": 82064.0, "length": 718, "protein_name": "Exostosin-2", "gene_name": "Ext2", "organism": "Mouse", "refseq_name": "exostosin-2 isoform 2", "refseq_ac": [ { "id": "NP_034293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034293", "type": "external" } ], "gene_names_uniprotkb": "Ext2", "gene_names_refseq": "Ext2", "protein_names_uniprotkb": "Exostosin-2; 2.4.1.224; Exostosin glycosyltransferase 2; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2 homolog", "protein_names_refseq": "exostoses (multiple) 2; exostosin-2 isoform 2; exostosin-2; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N- acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; multiple exostoses protein 2 homolog", "tax_id": 10090, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206)", "pathway": " (mmu:14043); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10639137;18337501;20173027;21750661;22872234;25428506;25468659;27650265;30084848;30779550;30977233;31219806;31599954;34203471;34428180;35820727;9110175;9232192", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors (PubMed:10639137). Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation. Publication Status: Online-Only, [RefSeq, PubMed]; Let-7b-mediated suppression of initiation codon depends on the length of 5'-UTR of EXT2 mRNA and its suppression is inhibited in the presence of polyamines. Publication Status: Online-Only, [RefSeq, PubMed]; Using mouse embryonic stem cell-derived mosaic tissues with compartments that lack Exostosin1 and Exostosin2, or Glypican5, it has been shown that Shh accumulates around its source cells when they are surrounded by cells that have a mutated extracellular matrix., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70395;Q3TPI7;Q923D6", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051923 sulfation;GO:0000271 polysaccharide biosynthetic process;GO:0030154 cell differentiation;GO:0008217 regulation of blood pressure;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P70428-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16858-1", "uniprot_id": [ { "id": "G3P_MOUSE", "url": "https://www.uniprot.org/uniprot/P16858", "type": "external" } ], "mass": 35810.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "Gapdh", "organism": "Mouse", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase isoform 1", "refseq_ac": [ { "id": "NP_001276655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276655", "type": "external" } ], "gene_names_uniprotkb": "Gapdh; Gapd", "gene_names_refseq": "Gapdh; Gapd", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase isoform 1; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14433); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 54, "publication_id_list": "11465105;11801660;16075062;16393994;16479539;16751257;17121833;17322886;18250455;18809573;19903941;20972425;2145197;21750661;22517741;22872234;23071094;25153642;25428506;25428507;25605945;26495903;27802388;28011936;28135057;28528544;28935714;30031227;30084848;30779550;31219806;31599954;32152506;32782141;32848054;33300544;33649389;33725478;34203471;34428180;35820727;35822049;35984892;36288343;36852467;37453647;37507081;37828378;39627609;39927985;40021952;40885482;40997131;7595213", "class_list": "glycogene", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:19903941). Also shows nitrosylase activity, thereby playing a role in nuclear functions (PubMed:19903941). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; GAPDH interacts with transferrin and the GAPDH-transferrin complex is subsequently internalized into the early endosomes. GeneRIF: Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor., [RefSeq, PubMed]; Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase., [RefSeq, PubMed]; Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability., [RefSeq, PubMed]; This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6A8;Q0QEU0;Q3THM2;Q3TUI2;Q3UMT2;Q4V783;Q569X2;Q569X5;Q5U410", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031906 late endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0001819 positive regulation of cytokine production;GO:0006094 gluconeogenesis;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "P16858-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y75-1", "uniprot_id": [ { "id": "DJB13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y75", "type": "external" } ], "mass": 36155.0, "length": 316, "protein_name": "DnaJ homolog subfamily B member 13", "gene_name": "Dnajb13", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 13", "refseq_ac": [ { "id": "NP_705755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705755", "type": "external" } ], "gene_names_uniprotkb": "Dnajb13; Tsarg3; Tsarg6; Tsarg", "gene_names_refseq": "1700014P03Rik; Dnajb13; Tsarg", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 13; Testis and spermatogenesis cell-related protein 6; Testis spermatocyte apoptosis-related gene 6 protein; Testis spermatogenesis apoptosis-related gene 3 protein; Testis spermatogenesis apoptosis-related gene 6 protein", "protein_names_refseq": "DnaJ (Hsp40) related, subfamily B, member 13; dnaJ homolog subfamily B member 13; spermatogenesis apoptosis-related protein; testis and spermatogenesis cell-related protein 6; testis spermatocyte apoptosis-related gene 6 protein; testis spermatogenesis apoptosis-related gene 3 protein; testis spermatogenesis apoptosis-related gene 6 protein", "tax_id": 10090, "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305); primary ciliary dyskinesia 34 (Disease Ontology:DOID:0110610)", "pathway": " (mmu:69387)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12673577;14673507;18247331;19298648;19919626;21750661;27530713;29298896;36417862", "class_list": "", "function": "DNAJB13 might be involved in assembly and stability of axoneme during sperm flagellum development., [RefSeq, PubMed]; Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia., [UniProtKB, PubMed, PubMed]; The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJA2", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904158 axonemal central apparatus assembly;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0006457 protein folding;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80Y75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2D3-1", "uniprot_id": [ { "id": "EDC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2D3", "type": "external" } ], "mass": 55957.0, "length": 508, "protein_name": "Enhancer of mRNA-decapping protein 3", "gene_name": "Edc3", "organism": "Mouse", "refseq_name": "enhancer of mRNA-decapping protein 3 isoform 1", "refseq_ac": [ { "id": "NP_722494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722494", "type": "external" } ], "gene_names_uniprotkb": "Edc3; Yjdc", "gene_names_refseq": "Edc3; Lsm16; Yjdc", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 3; YjeF domain-containing protein 1", "protein_names_refseq": "enhancer of mRNA decapping 3 homolog; enhancer of mRNA-decapping protein 3 isoform 1; enhancer of mRNA-decapping protein 3; yjeF domain-containing protein 1", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 50 (Disease Ontology:DOID:0081213)", "pathway": " (mmu:353190); (R-MMU-430039)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17242355;20051463;21183079;21750661;25428506;28528544;34428180", "class_list": "", "function": "Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity)., [UniProtKB, UniProtKB]; Induction of 14-3-3 binding to EDC3 causes morphological changes in processing body structures, inhibition of microRNA-mediated mRNA post-transcriptional regulation, and alterations in the protein- protein interactions of EDC3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THV7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0033962 P-body assembly;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K2D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6Y9-1", "uniprot_id": [ { "id": "GLGB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6Y9", "type": "external" } ], "mass": 80364.0, "length": 702, "protein_name": "1,4-alpha-glucan-branching enzyme", "gene_name": "Gbe1", "organism": "Mouse", "refseq_name": "1,4-alpha-glucan-branching enzyme", "refseq_ac": [ { "id": "NP_083079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083079", "type": "external" } ], "gene_names_uniprotkb": "Gbe1", "gene_names_refseq": "2310045H19Rik; 2810426P10Rik; D16Ertd536e; Gbe1", "protein_names_uniprotkb": "1,4-alpha-glucan-branching enzyme; 2.4.1.18; Brancher enzyme; Glycogen-branching enzyme", "protein_names_refseq": "1,4-alpha-glucan-branching enzyme; brancher enzyme; glucan (1,4-alpha-), branching enzyme 1; glycogen-branching enzyme", "tax_id": 10090, "disease": "porphyria (Disease Ontology:DOID:13268); glycogen storage disease IV (Disease Ontology:DOID:2750); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:74185); (R-MMU-3322077)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20300197;21075835;21750661;31219806;32152506;33049291;33857563;34428180;37453647;37507081", "class_list": "glycogene;glycosylhydrolase", "function": "Alteration of mitochondrial function in the livers of mice with glycogen branching enzyme deficiency., [RefSeq, PubMed]; GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1) Publication Status: Online-Only, [RefSeq, PubMed]; Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer., [UniProtKB, UniProtKB]; Hallmarks of oxidative stress in the livers of aged mice with mild glycogen branching enzyme deficiency., [RefSeq, PubMed]; Results reveal that early molecular events associated with Gbe1 deficiency contribute to abnormal cardiac development and fetal hydrops in the fetal form of glycogen storage disease type IV, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0030246 carbohydrate binding;GO:0003844 1,4-alpha-glucan branching enzyme activity;GO:0043169 cation binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D6Y9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7J6-1", "uniprot_id": [ { "id": "DNSL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7J6", "type": "external" } ], "mass": 35604.0, "length": 314, "protein_name": "Deoxyribonuclease-1-like 1", "gene_name": "Dnase1l1", "organism": "Mouse", "refseq_name": "deoxyribonuclease-1-like 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001165625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165625", "type": "external" } ], "gene_names_uniprotkb": "Dnase1l1", "gene_names_refseq": "2310005K03Rik; Dnase1l1; Dnase1ll; Dnasex; Dnl1ll; G4.8", "protein_names_uniprotkb": "Deoxyribonuclease-1-like 1; 3.1.21.-; DNase I-like 1; DNase X; Deoxyribonuclease I-like 1", "protein_names_refseq": "DNase I-like 1; DNase X; deoxyribonuclease I-like 1; deoxyribonuclease-1-like 1 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69537); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16107205;18250455;21750661;24098122;25428506;25605945;32152506", "class_list": "", "function": "Yeast two-hybrid screening revealed that DNase X, a glycosylphosphatidyl inositol-anchored mammalian cell-surface protein binds EtpE-C., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD56", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004530 deoxyribonuclease I activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004536 DNA nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D7J6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJY4-1", "uniprot_id": [ { "id": "DDX20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJY4", "type": "external" } ], "mass": 91710.0, "length": 825, "protein_name": "Probable ATP-dependent RNA helicase DDX20", "gene_name": "Ddx20", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX20", "refseq_ac": [ { "id": "NP_059093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059093", "type": "external" } ], "gene_names_uniprotkb": "Ddx20; Dp103; Gemin3", "gene_names_refseq": "Ddx20; GEMIN3; dp103", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX20; 3.6.1.15; 3.6.4.13; Component of gems 3; DEAD box protein 20; DEAD box protein DP 103; Gemin-3; ROSF-1; Regulator of steroidogenic factor 1", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; ROSF-1; component of gems 3; gemin-3; probable ATP-dependent RNA helicase DDX20; regulator of steroidogenic factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:53975); (R-MMU-191859)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10767334;11145740;16153597;19892989;21183079;21750661;25153642;25428506;26495903;28528544;30084848;34231259;34428180;38552910;38657611", "class_list": "", "function": "DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice., [RefSeq, PubMed]; DDX20 positively regulates the interferon pathway to inhibit viral infection., [RefSeq, PubMed]; Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059Z6;Q9JIK4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0032797 SMN complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JJY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D832-1", "uniprot_id": [ { "id": "DNJB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D832", "type": "external" } ], "mass": 37782.0, "length": 337, "protein_name": "DnaJ homolog subfamily B member 4", "gene_name": "Dnajb4", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 4 isoform 1", "refseq_ac": [ { "id": "NP_080202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080202", "type": "external" } ], "gene_names_uniprotkb": "Dnajb4", "gene_names_refseq": "1700029A20Rik; 2010306G19Rik; 5730460G06Rik; Dnajb4", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 4", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 4; dnaJ homolog subfamily B member 4 isoform 1; dnaJ homolog subfamily B member 4", "tax_id": 10090, "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305); distal myopathy (Disease Ontology:DOID:11720)", "pathway": " (mmu:67035)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25428506;30084848;31599954;34428180;36264506;36512060;37828378", "class_list": "", "function": "Distinctive chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4., [RefSeq, PubMed]; Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure., [RefSeq, PubMed]; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS92;Q9D9U2", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030018 Z disc", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D832-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN1-1", "uniprot_id": [ { "id": "DOC2G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN1", "type": "external" } ], "mass": 43347.0, "length": 387, "protein_name": "Double C2-like domain-containing protein gamma", "gene_name": "Doc2g", "organism": "Mouse", "refseq_name": "double C2-like domain-containing protein gamma", "refseq_ac": [ { "id": "NP_068563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068563", "type": "external" } ], "gene_names_uniprotkb": "Doc2g", "gene_names_refseq": "D830013O18Rik; Doc2g", "protein_names_uniprotkb": "Double C2-like domain-containing protein gamma; Doc2-gamma", "protein_names_refseq": "doc2-gamma; double C2-like domain-containing protein gamma", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:60425)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11027523;21750661", "class_list": "", "function": "May be involved in regulation of vesicular trafficking. In vitro, does not bind calcium and phospholipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8R8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0061669 spontaneous neurotransmitter secretion;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0A0-1", "uniprot_id": [ { "id": "DET1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0A0", "type": "external" } ], "mass": 63837.0, "length": 550, "protein_name": "DET1 homolog", "gene_name": "Det1", "organism": "Mouse", "refseq_name": "DET1 homolog isoform 1", "refseq_ac": [ { "id": "NP_083861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861", "type": "external" } ], "gene_names_uniprotkb": "Det1", "gene_names_refseq": "2610034H20Rik; Det1", "protein_names_uniprotkb": "DET1 homolog; De-etiolated-1 homolog", "protein_names_refseq": "DET1 homolog isoform 1; DET1 homolog; de-etiolated homolog 1; de-etiolated-1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76375); (R-MMU-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;29680877;31155351", "class_list": "", "function": "Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity)., [UniProtKB]; Mechanistically, cryptochromes inactivate Cop1 by interacting with Det1, a subunit of the mammalian CRL4(Cop1) complex that is not present in other CRL4s. Through this interaction, the ability of Cop1 to join the CRL4 complex is inhibited; therefore, its substrates accumulate. Thus, the interaction between cryptochromes and Det1 in mammals mirrors the interaction between cryptochromes and Cop1 in planta., [RefSeq, PubMed]; The role of ABF1/3/4 in det1 germination phenotypes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0031461 cullin-RING ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0A0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MJ9-1", "uniprot_id": [ { "id": "DDX50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MJ9", "type": "external" } ], "mass": 82175.0, "length": 734, "protein_name": "ATP-dependent RNA helicase DDX50", "gene_name": "Ddx50", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX50 isoform 1", "refseq_ac": [ { "id": "NP_444413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444413", "type": "external" } ], "gene_names_uniprotkb": "Ddx50", "gene_names_refseq": "4933429B04Rik; 8430408E17Rik; Ddx50; GU2; RH-II", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX50; 3.6.4.13; DEAD box protein 50; Gu-beta; Nucleolar protein Gu2", "protein_names_refseq": "ATP-dependent RNA helicase DDX50 isoform 1; ATP-dependent RNA helicase DDX50; DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD box protein 50; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50; RH-II/Gubeta; gu-beta; nucleolar protein GU2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94213)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11891046;21750661;22872234;31219806;34428180;36210013", "class_list": "", "function": "ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99MJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLY7-1", "uniprot_id": [ { "id": "DUS14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLY7", "type": "external" } ], "mass": 22311.0, "length": 198, "protein_name": "Dual specificity protein phosphatase 14", "gene_name": "Dusp14", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 14", "refseq_ac": [ { "id": "NP_062793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062793", "type": "external" } ], "gene_names_uniprotkb": "Dusp14; Mkp6", "gene_names_refseq": "1110014C10Rik; 2310042C07Rik; D11Ertd395e; Dusp14; MKP-L; Mkp6", "protein_names_uniprotkb": "Dual specificity protein phosphatase 14; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 6; MKP-6; Mitogen-activated protein kinase phosphatase 6", "protein_names_refseq": "MAP kinase phosphatase 6; MAP kinase phsophatase 6; Mkp-1 like protein tyrosine phosphatase; dual specificity protein phosphatase 14; mitogen-activated protein kinase phosphatase 6", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:56405)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11123293;17337450;21750661;30638656;31219806;31526569", "class_list": "", "function": "Critical role for JNK1 in the regulation of Mkp1 induction and in LPS-dependent macrophage activation., [RefSeq, PubMed]; DUSP14 up-regulation inhibits inflammation and oxidative stress in brain of cerebral ischemia/reperfusion mice. DUSP14 evokes Nrf-2-meditated anti-oxidative stress and inflammatory response., [RefSeq, PubMed]; Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation., [UniProtKB, UniProtKB]; Results indicate that dual specificity phosphatase 14 (Dusp14) as an important molecular switch resulting in osteoporosis through an protein kinase AMP-activated alpha 1 catalytic subunit (AMPKalpha)-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D715", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JLY7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7B1-1", "uniprot_id": [ { "id": "DUS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7B1", "type": "external" } ], "mass": 55325.0, "length": 493, "protein_name": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like", "gene_name": "Dus2", "organism": "Mouse", "refseq_name": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2", "refseq_ac": [ { "id": "NP_001288105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288105", "type": "external" } ], "gene_names_uniprotkb": "Dus2; Dus2l", "gene_names_refseq": "2310016K04Rik; Dus2l; Dus2", "protein_names_uniprotkb": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; 1.3.1.91; Dihydrouridine synthase 2; tRNA-dihydrouridine synthase 2-like", "protein_names_refseq": "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66369); (R-MMU-9833482)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs. Activity depends on the presence of guanosine at position 19 in the tRNA substrate. Negatively regulates the activation of EIF2AK2/PKR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDX2", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.3.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.91", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0000049 tRNA binding;GO:0004860 protein kinase inhibitor activity;GO:0003725 double-stranded RNA binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ36-1", "uniprot_id": [ { "id": "DPOE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ36", "type": "external" } ], "mass": 12240.0, "length": 118, "protein_name": "DNA polymerase epsilon subunit 4", "gene_name": "Pole4", "organism": "Mouse", "refseq_name": "DNA polymerase epsilon subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_080158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080158", "type": "external" } ], "gene_names_uniprotkb": "Pole4", "gene_names_refseq": "2400007P05Rik; 5830430F06Rik; Pole4", "protein_names_uniprotkb": "DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12", "protein_names_refseq": "DNA polymerase II subunit 4; DNA polymerase epsilon subunit 4 isoform 1; DNA polymerase epsilon subunit 4; DNA polymerase epsilon subunit p12", "tax_id": 10090, "disease": "", "pathway": " (mmu:66979); (R-MMU-110314); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-68952); (R-MMU-68962)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "21750661;28135057", "class_list": "", "function": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ13", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0140672 ATAC complex", "go_biological_process": "GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQ36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVF7-1", "uniprot_id": [ { "id": "DPOE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVF7", "type": "external" } ], "mass": 262100.0, "length": 2283, "protein_name": "DNA polymerase epsilon catalytic subunit A", "gene_name": "Pole", "organism": "Mouse", "refseq_name": "DNA polymerase epsilon catalytic subunit A", "refseq_ac": [ { "id": "NP_035262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035262", "type": "external" } ], "gene_names_uniprotkb": "Pole; Pole1", "gene_names_refseq": "Pole", "protein_names_uniprotkb": "DNA polymerase epsilon catalytic subunit A; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; DNA polymerase II subunit A", "protein_names_refseq": "3'-5' exodeoxyribonuclease; DNA polymerase II subunit A; DNA polymerase epsilon catalytic subunit A; DNA-directed DNA polymerase epsilon; pol-epsilon", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); duodenum cancer (Disease Ontology:DOID:10021); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); ascending colon cancer (Disease Ontology:DOID:218); ovarian cancer (Disease Ontology:DOID:2394); kidney cancer (Disease Ontology:DOID:263); endometrial carcinoma (Disease Ontology:DOID:2871); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18973); (R-MMU-110314); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-68952); (R-MMU-68962)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "10366722;16479539;21750661;22872234;25428506;31219806;34203471;34428180;36210013", "class_list": "", "function": "Catalytic component of the DNA polymerase epsilon complex (By similarity). Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). It is also involved in DNA synthesis during DNA repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; DNA polymerase II participates in chromosomal DNA replication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKW1;Q9QX50", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006272 leading strand elongation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVF7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1C6-1", "uniprot_id": [ { "id": "DGKE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1C6", "type": "external" } ], "mass": 63635.0, "length": 564, "protein_name": "Diacylglycerol kinase epsilon", "gene_name": "Dgke", "organism": "Mouse", "refseq_name": "diacylglycerol kinase epsilon isoform 1", "refseq_ac": [ { "id": "NP_062378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062378", "type": "external" } ], "gene_names_uniprotkb": "Dgke", "gene_names_refseq": "DAGK6; DGK-epsilon; DGK; Dgke", "protein_names_uniprotkb": "Diacylglycerol kinase epsilon; 2.7.1.107; DAG kinase epsilon; DGK-epsilon; Diglyceride kinase epsilon", "protein_names_refseq": "DAG kinase epsilon; diacylglycerol kinase epsilon isoform 1; diglyceride kinase epsilon", "tax_id": 10090, "disease": "nephrotic syndrome type 7 (Disease Ontology:DOID:0080388)", "pathway": " (mmu:56077); (R-MMU-114508)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11287665;16137646;19744926;21750661;23542698;25428506;31219806;33300544;35616094;36113832;37875386;38008259", "class_list": "", "function": "A regulatory role is suggested for DGK epsilon, COX-2, and catecholamine signaling during kindling epileptogenesis., [RefSeq, PubMed]; Ablation of diacylglycerol kinase epsilon promotes whitening of brown adipose tissue under high fat diet feeding., [RefSeq, PubMed]; An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-epsilon., [RefSeq, PubMed]; Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Kruppel-like factor 15/klotho pathway., [RefSeq, PubMed]; Diacylglycerol kinase-epsilon is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment., [RefSeq, PubMed]; Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11287665). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11287665). Also plays an important role in the biosynthesis of complex lipids (By similarity). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:11287665, PubMed:19744926). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SU69", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R1C6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIW4-1", "uniprot_id": [ { "id": "DPOLM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIW4", "type": "external" } ], "mass": 55490.0, "length": 496, "protein_name": "DNA-directed DNA/RNA polymerase mu", "gene_name": "Polm", "organism": "Mouse", "refseq_name": "DNA-directed DNA/RNA polymerase mu", "refseq_ac": [ { "id": "NP_059097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059097", "type": "external" } ], "gene_names_uniprotkb": "Polm; polmu", "gene_names_refseq": "B230309I03Rik; Polm; Tdt-N", "protein_names_uniprotkb": "DNA-directed DNA/RNA polymerase mu; 2.7.7.7; Pol Mu; Terminal transferase", "protein_names_refseq": "DNA polymerase mu; DNA-directed DNA polymerase mu; DNA-directed DNA/RNA polymerase mu; pol Mu; terminal transferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:54125); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10747040;10982892;11937519;16860755;17159995;21183079;21750661;28460268;31138645;31219806;31599954;34428180;39179163", "class_list": "", "function": "A role for PolMU in the prevention of sarcomagenesis on a murine P53-deficient background was identified., [RefSeq, PubMed]; Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks (By similarity). Functions as a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ) (By similarity). Displays reduced sugar discrimination, incorporating deoxyribonucleotides and ribonucleotides with similar efficiency on DNA primer strands, and is able to polymerize nucleotides on RNA-terminated primer strands in vitro (By similarity). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination (PubMed:16860755)., [UniProtKB, PubMed, UniProtKB]; Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ)., [UniProtKB, UniProtKB]; Interneurons in the CA1 stratum oriens expressing alphaTTP may play a role in the delayed-ageing Pol mu mouse model., [RefSeq, PubMed]; Pol mu is not required for normal Ig gene hypermutation., [RefSeq, PubMed]; The atomic structure of an NHEJ junction with a Pol x construct that mimics Pol mu in a reconstituted system explained the distinctive properties of Pol mu compared with TdT. The structure suggested a mechanism of base selection relying on Loop1 and taking instructions via the in trans templating base independently of the primer strand., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E840;Q9JJW9", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0030183 B cell differentiation;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JIW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N11-1", "uniprot_id": [ { "id": "DUS22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N11", "type": "external" } ], "mass": 20997.0, "length": 184, "protein_name": "Dual specificity protein phosphatase 22", "gene_name": "Dusp22", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 22 isoform a", "refseq_ac": [ { "id": "NP_001033044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033044", "type": "external" } ], "gene_names_uniprotkb": "Dusp22", "gene_names_refseq": "Dusp22; JKAP; JSP1; LMW-DSP2; MKPX", "protein_names_uniprotkb": "Dual specificity protein phosphatase 22; 3.1.3.16; 3.1.3.48; JKAP; JNK pathway associated phosphatase; LMW-DSP2; Low molecular weight dual specificity phosphatase 2", "protein_names_refseq": "JNK pathway associated phosphatase; dual specificity protein phosphatase 22 isoform a; dual specificity protein phosphatase 22; low molecular weight dual specificity phosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105352)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11346645;12138158;16636663;21750661;24714587;29282540;31219806;36209205;36765305;38797677", "class_list": "", "function": "Cloning and characterization of JKAP, a positive regulator of the JNK pathway, [RefSeq, PubMed]; DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway., [RefSeq, PubMed]; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (By similarity). Activates the JNK signaling pathway (By similarity). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (By similarity). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (By similarity). Dephosphorylates and thereby inactivates tyrosine kinase LCK (By similarity). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (By similarity). May play a role in B-cell receptor (BCR) signaling and B-cell function (PubMed:24714587)., [UniProtKB, UniProtKB, PubMed]; Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis. Publication Status: Online-Only, [RefSeq, PubMed]; Dusp22 expression in the adult mouse tissues and organs, [RefSeq, PubMed]; Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK. Publication Status: Online-Only, [RefSeq, PubMed]; JNK Pathway-Associated Phosphatase Deficiency Facilitates Atherosclerotic Progression by Inducing T-Helper 1 and 17 Polarization and Inflammation in an ERK- and NF-kappaB Pathway-Dependent Manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SQN9;Q5SQP0", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0030292 protein tyrosine kinase inhibitor activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031941 filamentous actin", "go_biological_process": "GO:0002710 negative regulation of T cell mediated immunity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0042127 regulation of cell population proliferation;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99N11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWP8-1", "uniprot_id": [ { "id": "DPOD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWP8", "type": "external" } ], "mass": 12403.0, "length": 107, "protein_name": "DNA polymerase delta subunit 4", "gene_name": "Pold4", "organism": "Mouse", "refseq_name": "DNA polymerase delta subunit 4", "refseq_ac": [ { "id": "NP_081472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081472", "type": "external" } ], "gene_names_uniprotkb": "Pold4", "gene_names_refseq": "2410012M21Rik; Pold4; Polds; p12", "protein_names_uniprotkb": "DNA polymerase delta subunit 4; DNA polymerase delta subunit p12", "protein_names_refseq": "DNA polymerase delta smallest subunit p12; DNA polymerase delta subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69745); (R-MMU-110314); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174437); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 19, "publication_count": 4, "publication_id_list": "21750661;23233665;34428180;36356905", "class_list": "", "function": "As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival., [UniProtKB, UniProtKB]; Pold4 is dispensable for mouse development, DNA replication and DNA repair., [RefSeq, PubMed]; The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways. Erratum:[J Biol Chem. 2014 Jan 17;289(3):1212], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005634 nucleus", "go_biological_process": "GO:0001938 positive regulation of endothelial cell proliferation;GO:0000731 DNA synthesis involved in DNA repair;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CWP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXV1-1", "uniprot_id": [ { "id": "DHSD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXV1", "type": "external" } ], "mass": 17014.0, "length": 159, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "Sdhd", "organism": "Mouse", "refseq_name": "succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "refseq_ac": [ { "id": "NP_080124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080124", "type": "external" } ], "gene_names_uniprotkb": "Sdhd", "gene_names_refseq": "3110001M13Rik; AVLL5809; CII-4; PRO19626; QPs3; Sdhd; cybS", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CII-4; CybS; Malate dehydrogenase [quinone] cytochrome b small subunit; QPs3; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit", "protein_names_refseq": "malate dehydrogenase [quinone] cytochrome b small subunit; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex subunit D; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit", "tax_id": 10090, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:66925); (R-MMU-71403); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "20173027;25605945;27802388;30084848;30779550;33023985;34428180", "class_list": "", "function": "Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H629;Q3UX11", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008177 succinate dehydrogenase (quinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0071456 cellular response to hypoxia;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0050433 regulation of catecholamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CXV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D311-1", "uniprot_id": [ { "id": "DOXA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D311", "type": "external" } ], "mass": 35427.0, "length": 320, "protein_name": "Dual oxidase maturation factor 2", "gene_name": "Duoxa2", "organism": "Mouse", "refseq_name": "dual oxidase maturation factor 2", "refseq_ac": [ { "id": "NP_080053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080053", "type": "external" } ], "gene_names_uniprotkb": "Duoxa2", "gene_names_refseq": "9030623N16Rik; Duoxa2; Nip2", "protein_names_uniprotkb": "Dual oxidase maturation factor 2", "protein_names_refseq": "Numb-interacting protein 2; dual oxidase maturation factor 2", "tax_id": 10090, "disease": "thyroid dyshormonogenesis 5 (Disease Ontology:DOID:0112184)", "pathway": " (mmu:66811); (R-MMU-209968)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the maturation and transport of functional DUOX2 from the endoplasmic reticulum to the plasma membrane. Recruits DUOX2 to the apical cell membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ98;Q9D7U8", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010729 positive regulation of hydrogen peroxide biosynthetic process;GO:0015031 protein transport;GO:0072659 protein localization to plasma membrane;GO:0050727 regulation of inflammatory response;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D311-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3F7-1", "uniprot_id": [ { "id": "DDIT4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3F7", "type": "external" } ], "mass": 24871.0, "length": 229, "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "Ddit4", "organism": "Mouse", "refseq_name": "DNA damage-inducible transcript 4 protein", "refseq_ac": [ { "id": "NP_083359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083359", "type": "external" } ], "gene_names_uniprotkb": "Ddit4; Dig2; Redd1; Rtp801", "gene_names_refseq": "5830413E08Rik; Ddit4; REDD1; Rtp801; dig2", "protein_names_uniprotkb": "DNA damage-inducible transcript 4 protein; Dexamethasone-induced gene 2 protein; HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1", "protein_names_refseq": "DNA damage-inducible transcript 4 protein; HIF-1 responsive RTP801; HIF-1 responsive protein RTP801; REDD-1; dexamethasone-induced gene 2 protein; protein regulated in development and DNA damage response 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74747); (R-MMU-5628897)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11884613;12453409;12736248;15452091;15545625;15988001;17005863;20176937;21383064;21896779;21909097;25428506;34428180;38928166;39004152", "class_list": "", "function": "Dig2 appears to have a pro-survival function, as overexpression of dig2 reduces the sensitivity of WEHI7.2 cells to dexamethasone-induced apoptosis., [RefSeq, PubMed]; REDD1 Deletion Suppresses NF-kappaB Signaling in Cardiomyocytes and Prevents Deficits in Cardiac Function in Diabetic Mice. Publication Status: Online-Only, [RefSeq, PubMed]; REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation [REDD1], [RefSeq, PubMed]; REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress., [RefSeq, PubMed]; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051607 defense response to virus;GO:0001666 response to hypoxia;GO:0001764 neuron migration;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D3F7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D844-1", "uniprot_id": [ { "id": "DNJC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D844", "type": "external" } ], "mass": 28206.0, "length": 244, "protein_name": "DnaJ homolog subfamily C member 4", "gene_name": "Dnajc4", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 4 isoform c", "refseq_ac": [ { "id": "NP_065591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065591", "type": "external" } ], "gene_names_uniprotkb": "Dnajc4; Mcg18", "gene_names_refseq": "Dnajc4; Hspf2; Mcg18", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 4; Multiple endocrine neoplasia type 1 candidate protein number 18 homolog", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 4; dnaJ homolog subfamily C member 4 isoform c; dnaJ homolog subfamily C member 4; heat shock 40kD protein 2; multiple endocrine neoplasia type 1 candidate protein 18; multiple endocrine neoplasia type 1 candidate protein number 18 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:57431)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9473517", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70278", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D844-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ06-1", "uniprot_id": [ { "id": "DHB11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ06", "type": "external" } ], "mass": 32881.0, "length": 298, "protein_name": "Estradiol 17-beta-dehydrogenase 11", "gene_name": "Hsd17b11", "organism": "Mouse", "refseq_name": "estradiol 17-beta-dehydrogenase 11 precursor", "refseq_ac": [ { "id": "NP_444492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444492", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b11; Dhrs8; Pan1b", "gene_names_refseq": "Dhrs8; Hsd17b11; Pan1b; SDR2; retSDR2", "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 11; 1.1.1.62; 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17betaHSD11; 17betaHSDXI; Dehydrogenase/reductase SDR family member 8", "protein_names_refseq": "17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17beta-HSD11; 17betaHSD11; 17betaHSDXI; dehydrogenase/reductase (SDR family) member 8; estradiol 17-beta-dehydrogenase 11 precursor; estradiol 17-beta-dehydrogenase 11; retinal short-chain dehydrogenase/reductase 2; retinal short-chain dehydrogenase/reductase SDR2", "tax_id": 10090, "disease": "", "pathway": " (mmu:114664); (R-MMU-193144)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "11165019;17714510;18359291;19224205;19892989;20173027;25428506;25428507;25605945;26495903;27802388;29187734;30084848;30779550;34428180;35820727;37453647;37507081", "class_list": "", "function": "Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione., [UniProtKB]; Data indicate that 17beta-HSD11 localizes both in the endoplasmic reticulum and in lipid droplets, depending on physiologic conditions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2P6;Q8BR33;Q8C7S0", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006710 androgen catabolic process;GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9EQ06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY48-1", "uniprot_id": [ { "id": "DNS2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY48", "type": "external" } ], "mass": 40794.0, "length": 354, "protein_name": "Deoxyribonuclease-2-beta", "gene_name": "Dnase2b", "organism": "Mouse", "refseq_name": "deoxyribonuclease-2-beta precursor", "refseq_ac": [ { "id": "NP_064341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064341", "type": "external" } ], "gene_names_uniprotkb": "Dnase2b; Dlad", "gene_names_refseq": "Dlad; Dnase2b; DnaseIIb", "protein_names_uniprotkb": "Deoxyribonuclease-2-beta; 3.1.22.1; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; Deoxyribonuclease II beta; Endonuclease DLAD", "protein_names_refseq": "DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; deoxyribonuclease DLAD; deoxyribonuclease-2-beta precursor; deoxyribonuclease-2-beta; endonuclease DLAD", "tax_id": 10090, "disease": "cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:56629)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10497274;11700027;12944971;31219806", "class_list": "", "function": "Gene lie head-to-head with the urate oxidase gene, [RefSeq, PubMed]; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation., [UniProtKB, PubMed, PubMed]; The DLAD-/- mice develop cataracts of the nucleus lentis, and their response to light on electroretinograms is severely reduced; these results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8C589", "ec_number_list": [], "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QY48-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYI8-1", "uniprot_id": [ { "id": "DNJB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYI8", "type": "external" } ], "mass": 35626.0, "length": 312, "protein_name": "DnaJ homolog subfamily B member 7", "gene_name": "Dnajb7", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 7", "refseq_ac": [ { "id": "NP_067292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067292", "type": "external" } ], "gene_names_uniprotkb": "Dnajb7", "gene_names_refseq": "4933424H20Rik; Dj5; Dnajb7; mDj5", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 7; mDj5", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 7; dnaJ homolog subfamily B member 7; dnaJ-like 5", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (mmu:57755)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11147971;37004113", "class_list": "", "function": "DNAJB7 is dispensable for male fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Probably acts as a co-chaperone., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DA41", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYI8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZZ6-1", "uniprot_id": [ { "id": "DERM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZZ6", "type": "external" } ], "mass": 23995.0, "length": 201, "protein_name": "Dermatopontin", "gene_name": "Dpt", "organism": "Mouse", "refseq_name": "dermatopontin precursor", "refseq_ac": [ { "id": "NP_062733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062733", "type": "external" } ], "gene_names_uniprotkb": "Dpt", "gene_names_refseq": "1810032B19Rik; 5033416F05Rik; Dpt; EQ-1; Eq1", "protein_names_uniprotkb": "Dermatopontin; EQ-1; Early quiescence protein 1; TRAMP; Tyrosine-rich acidic matrix protein", "protein_names_refseq": "TRAMP; dermatopontin precursor; early quiescence protein-1; tyrosine-rich acidic matrix protein", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:56429)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12230512;14980498", "class_list": "", "function": "Cloning of early quiescence-1 gene: Identification of a role in cell quiescence., [RefSeq, PubMed]; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation., [UniProtKB, PubMed, PubMed]; Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2B6", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HXL6-1", "uniprot_id": [ { "id": "EDEM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2HXL6", "type": "external" } ], "mass": 104200.0, "length": 931, "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 3", "gene_name": "Edem3", "organism": "Mouse", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001034733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034733", "type": "external" } ], "gene_names_uniprotkb": "Edem3", "gene_names_refseq": "2310050N11Rik; Edem3", "protein_names_uniprotkb": "ER degradation-enhancing alpha-mannosidase-like protein 3; 3.2.1.113; Alpha-1,2-mannosidase EDEM3", "protein_names_refseq": "ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1 precursor; ER degradation-enhancing alpha-mannosidase-like protein 3; alpha-1,2-mannosidase EDEM3", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIv (Disease Ontology:DOID:0051050)", "pathway": " (mmu:66967)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16431915;17499246;21750661;30899004;33671632;34143952;34428180;35820727;39627609", "class_list": "glycogene;glycosylhydrolase", "function": "EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning. Publication Status: Online-Only, [RefSeq, PubMed]; EDEM3 has alpha1,2-mannosidase activity in vivo, suggesting that the mechanism whereby EDEM3 accelerates glycoprotein ERAD is different from that of EDEM, [RefSeq, PubMed]; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RS10;B9EHZ4;Q6P9L0", "ec_number_list": [ { "id": "3.2.1.113", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.113", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q2HXL6-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYI7-1", "uniprot_id": [ { "id": "DNJB8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYI7", "type": "external" } ], "mass": 25230.0, "length": 227, "protein_name": "DnaJ homolog subfamily B member 8", "gene_name": "Dnajb8", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 8", "refseq_ac": [ { "id": "NP_064348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064348", "type": "external" } ], "gene_names_uniprotkb": "Dnajb8", "gene_names_refseq": "1700016F14Rik; 1700031F10Rik; Dnajb8; mDj6", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 8; mDj6", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 8; DnaJ homolog 6; dnaJ homolog subfamily B member 8", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (mmu:56691)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11147971;21750661;22552285;26751205", "class_list": "", "function": "Dnajb8 has a role in tumor initiation, side population ratio and sphere formation but it is dispensable for stress responses Publication Status: Online-Only, [RefSeq, PubMed]; Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins., [UniProtKB]; Findings suggest that DNAJB8 plays a role in Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0D5-1", "uniprot_id": [ { "id": "EFL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0D5", "type": "external" } ], "mass": 125777.0, "length": 1127, "protein_name": "Elongation factor-like GTPase 1", "gene_name": "Efl1", "organism": "Mouse", "refseq_name": "elongation factor-like GTPase 1", "refseq_ac": [ { "id": "NP_001153144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153144", "type": "external" } ], "gene_names_uniprotkb": "Efl1; Eftud1", "gene_names_refseq": "4932434J20Rik; 6030468D11Rik; D7Ertd791e; Efl1; Eftud1", "protein_names_uniprotkb": "Elongation factor-like GTPase 1; 3.6.5.-; Elongation factor Tu GTP-binding domain-containing protein 1; Elongation factor-like 1; Protein FAM42A", "protein_names_refseq": "elongation factor Tu GTP binding domain containing 1; elongation factor Tu GTP-binding domain-containing protein 1; elongation factor like GPTase 1; elongation factor-like 1; elongation factor-like GTPase 1", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (mmu:101592)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;37709489;39627609", "class_list": "", "function": "Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration., [RefSeq, PubMed]; GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W46;Q8C198;Q8K0B8", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0046039 GTP metabolic process;GO:0042256 cytosolic ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C0D5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYI6-1", "uniprot_id": [ { "id": "DNJB9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYI6", "type": "external" } ], "mass": 25616.0, "length": 222, "protein_name": "DnaJ homolog subfamily B member 9", "gene_name": "Dnajb9", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 9 precursor", "refseq_ac": [ { "id": "NP_038788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038788", "type": "external" } ], "gene_names_uniprotkb": "Dnajb9", "gene_names_refseq": "Dnajb9; ERdj4; Mdg1; mDj7", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 9; ER-resident protein ERdj4; ERdj4; Endoplasmic reticulum DNA J domain-containing protein 4; mDj7", "protein_names_refseq": "DNA j protein b9; DnaJ (Hsp40) homolog, subfamily B, member 9; ER-resident protein ERdj4; dnaJ homolog subfamily B member 9 precursor; dnaJ homolog subfamily B member 9; endoplasmic reticulum DNA J domain-containing protein 4; microvascular endothelial differentiation gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27362)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11147971;11836248;21750661;22267725;24336520;25222125;27546788", "class_list": "", "function": "Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725). Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; DnaJ homolog, which stimulates ATPase activity of BiP and is induced by endoplasmic reticulum stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D0C3;Q9DAW1", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030183 B cell differentiation;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein;GO:1903895 negative regulation of IRE1-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QYI6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZD9-1", "uniprot_id": [ { "id": "EIF3I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZD9", "type": "external" } ], "mass": 36461.0, "length": 325, "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "Eif3i", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit I", "refseq_ac": [ { "id": "NP_061269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061269", "type": "external" } ], "gene_names_uniprotkb": "Eif3i; Eif3s2; Trip1", "gene_names_refseq": "36kDa; D4Ertd632e; Eif3i; Eif3s2; Trip1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; TRIP-1; eIF-3-beta; eIF3 p36; eIF3i", "protein_names_refseq": "TGF-beta receptor binding protein; TGF-beta receptor-interacting protein 1; TRIP-1; eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3, subunit 1; eukaryotic translation initiation factor 3, subunit 2 (beta); eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)", "tax_id": 10090, "disease": "", "pathway": " (mmu:54709); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "14971650;16541103;17581632;18299400;20173027;21750661;25428506;27883077;29484847;30084848;31219806;32236758;34428180;36210013;37453647;37689715", "class_list": "", "function": "CircEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, PubMed, HAMAP]; EIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G., [RefSeq, PubMed]; TRIP-1 is a secreted protein and is present in the secretome of primary osteoblasts and in the extracellular matrix.TRIP-1 binds to type I collagen.TRIP-1 promotes calcium phosphate deposition. Publication Status: Online-Only, [RefSeq, PubMed]; TRIP-1 overexpression protects alveolar epithelial cells against hyperoxic acute lung injury., [RefSeq, PubMed]; The up-regulation of expression of TIF3 is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QZD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2CI98-1", "uniprot_id": [ { "id": "DYTN_MOUSE", "url": "https://www.uniprot.org/uniprot/A2CI98", "type": "external" } ], "mass": 74059.0, "length": 653, "protein_name": "Dystrotelin", "gene_name": "Dytn", "organism": "Mouse", "refseq_name": "dystrotelin", "refseq_ac": [ { "id": "NP_001075127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075127", "type": "external" } ], "gene_names_uniprotkb": "Dytn; Gm215", "gene_names_refseq": "Dytn; Gm215", "protein_names_uniprotkb": "Dystrotelin", "protein_names_refseq": "dystrotelin", "tax_id": 10090, "disease": "", "pathway": " (mmu:241073)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17233888;34105348", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5F254", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2CI98-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0M5-1", "uniprot_id": [ { "id": "DYL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0M5", "type": "external" } ], "mass": 10350.0, "length": 89, "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "Dynll2", "organism": "Mouse", "refseq_name": "dynein light chain 2, cytoplasmic", "refseq_ac": [ { "id": "NP_001161943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161943", "type": "external" } ], "gene_names_uniprotkb": "Dynll2; Dlc2", "gene_names_refseq": "1700064A15Rik; 6720463E02Rik; DLC8b; DLC8; Dlc2; Dynll2", "protein_names_uniprotkb": "Dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; DLC8; Dynein light chain LC8-type 2", "protein_names_refseq": "8 kDa dynein light chain b; dynein light chain 2, cytoplasmic", "tax_id": 10090, "disease": "", "pathway": " (mmu:68097); (R-MMU-139910); (R-MMU-141430); (R-MMU-141444); (R-MMU-1632852); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-5620924); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 16, "publication_count": 12, "publication_id_list": "11148209;11546872;14561217;16479539;16981716;21750661;31189926;31219806;33300544;34428180;36417862;37828378", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)., [UniProtKB]; Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim., [RefSeq, PubMed]; These data show that alternative splicing of the myosin Va heavy chain controls DYNLL2-myosin Va interaction and that DYNLL2 binding alters the structure of a portion of the myosin's coiled-coil domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7M7R8;Q3TFB4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031475 myosin V complex;GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0005874 microtubule", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D0M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1G0-1", "uniprot_id": [ { "id": "DNSL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1G0", "type": "external" } ], "mass": 31138.0, "length": 278, "protein_name": "Deoxyribonuclease-1-like 2", "gene_name": "Dnase1l2", "organism": "Mouse", "refseq_name": "deoxyribonuclease-1-like 2 precursor", "refseq_ac": [ { "id": "NP_079994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079994", "type": "external" } ], "gene_names_uniprotkb": "Dnase1l2", "gene_names_refseq": "4733401H14Rik; Dnase1l2", "protein_names_uniprotkb": "Deoxyribonuclease-1-like 2; 3.1.21.-; DNase I-like 2; Deoxyribonuclease I-like 2", "protein_names_refseq": "DNase I-like 2; deoxyribonuclease I-like 2; deoxyribonuclease-1-like 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66705)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20173027;21307874;21750661;28928425;34329318", "class_list": "", "function": "Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris. Publication Status: Online-Only, [RefSeq, PubMed]; DNase1L2 as an essential and specific regulator of programmed cell death in skin appendages, and demonstrate that the breakdown of nuclear DNA is crucial for establishing the full mechanical stability of hair., [RefSeq, PubMed]; Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity)., [UniProtKB]; This study reports that lack of Trex2 results in the accumulation of DNA fragments in the cytoplasm of cornifying lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes massive accumulation of DNA fragments throughout the cornified layers of the tongue epithelium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQI2;Q9D645", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0004536 DNA nuclease activity;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001942 hair follicle development;GO:0006308 DNA catabolic process;GO:0003335 corneocyte development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D1G0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35723-1", "uniprot_id": [ { "id": "DNJB3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35723", "type": "external" } ], "mass": 26679.0, "length": 242, "protein_name": "DnaJ homolog subfamily B member 3", "gene_name": "Dnajb3", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 3", "refseq_ac": [ { "id": "NP_032325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032325", "type": "external" } ], "gene_names_uniprotkb": "Dnajb3; Hsj3; Msj1", "gene_names_refseq": "Dnajb3; Hsj3; MSJ-1; Msj1", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 3; DnaJ protein homolog 3; HSJ-3; Heat shock protein J3; MSJ-1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 3; HSJ-3; dnaJ homolog subfamily B member 3; dnaJ protein homolog 3; heat shock protein J3; heat shock protein, DNAJ-like 3", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (mmu:15504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12485825;37895206;9521861", "class_list": "", "function": "A molecular chaperone, specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells, [RefSeq, PubMed]; Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAN3;Q9DAN4", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35723-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22387-1", "uniprot_id": [ { "id": "EDN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P22387", "type": "external" } ], "mass": 22809.0, "length": 202, "protein_name": "Endothelin-1", "gene_name": "Edn1", "organism": "Mouse", "refseq_name": "endothelin-1 preproprotein", "refseq_ac": [ { "id": "NP_034234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034234", "type": "external" } ], "gene_names_uniprotkb": "Edn1", "gene_names_refseq": "ET-1; Edn1; PPET1; preproET", "protein_names_uniprotkb": "Endothelin-1; ET-1; PPET1; Preproendothelin-1", "protein_names_refseq": "endothelin-1 preproprotein; preproendothelin-1", "tax_id": 10090, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); metabolic acidosis (Disease Ontology:DOID:0050758); obstructive sleep apnea (Disease Ontology:DOID:0050848); atrial fibrillation (Disease Ontology:DOID:0060224); childhood-onset asthma (Disease Ontology:DOID:0080815); aortic atherosclerosis (Disease Ontology:DOID:10230); retinitis pigmentosa (Disease Ontology:DOID:10584); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); adult respiratory distress syndrome (Disease Ontology:DOID:11394); heart disease (Disease Ontology:DOID:114); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); angle-closure glaucoma (Disease Ontology:DOID:13550); exfoliation syndrome (Disease Ontology:DOID:13641); cystic fibrosis (Disease Ontology:DOID:1485); neovascular glaucoma (Disease Ontology:DOID:1687); impotence (Disease Ontology:DOID:1875); optic nerve disease (Disease Ontology:DOID:1891); hypogonadism (Disease Ontology:DOID:1924); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); renal artery disease (Disease Ontology:DOID:2388); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); coronary stenosis (Disease Ontology:DOID:4248); uremia (Disease Ontology:DOID:4676); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); retinal detachment (Disease Ontology:DOID:5327); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); anterolateral myocardial infarction (Disease Ontology:DOID:5845); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); chronic rhinitis (Disease Ontology:DOID:8252); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); hepatopulmonary syndrome (Disease Ontology:DOID:900); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13614); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16293765;20495147;21525433;2768235;3631552;38804865;39136472;7883980;8238383;8575440;8688455;8824799", "class_list": "", "function": "Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity., [RefSeq, PubMed]; Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway., [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (PubMed:20495147, PubMed:21525433). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (PubMed:20495147)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Tail stump sperm defect in Ayrshire bulls: morphogenesis of the defect., [RefSeq, PubMed]; This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 61, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70203;P97338", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031707 endothelin A receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0045178 basal part of cell;GO:0048237 rough endoplasmic reticulum lumen;GO:0033093 Weibel-Palade body", "go_biological_process": "GO:0030878 thyroid gland development;GO:0086100 endothelin receptor signaling pathway;GO:0042045 epithelial fluid transport;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22387-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22389-1", "uniprot_id": [ { "id": "EDN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P22389", "type": "external" } ], "mass": 19538.0, "length": 175, "protein_name": "Endothelin-2", "gene_name": "Edn2", "organism": "Mouse", "refseq_name": "endothelin-2 preproprotein", "refseq_ac": [ { "id": "NP_031928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031928", "type": "external" } ], "gene_names_uniprotkb": "Edn2", "gene_names_refseq": "ET-2; Edn2; PPET2; VIC", "protein_names_uniprotkb": "Endothelin-2; ET-2; PPET2; Preproendothelin-2; VIC; Vasoactive intestinal contractor", "protein_names_refseq": "endothelin-2 preproprotein; preproendothelin-2; vasoactive intestinal contractor peptide", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:13615); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10708518;1859843;2768235;31228092", "class_list": "", "function": "Endothelin ETA and ETB receptors seem to be involved in the oxaliplatin-induced peripheral sensory neuropathy in mice and they should be considered possible targets for the management of this clinical feature., [RefSeq, PubMed]; This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]., [RefSeq]; Vasoconstrictor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JME3", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0001543 ovarian follicle rupture;GO:0001525 angiogenesis;GO:0001659 temperature homeostasis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22389-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30728-1", "uniprot_id": [ { "id": "DRD3_MOUSE", "url": "https://www.uniprot.org/uniprot/P30728", "type": "external" } ], "mass": 49669.0, "length": 446, "protein_name": "D(3) dopamine receptor", "gene_name": "Drd3", "organism": "Mouse", "refseq_name": "D(3) dopamine receptor", "refseq_ac": [ { "id": "NP_031903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031903", "type": "external" } ], "gene_names_uniprotkb": "Drd3", "gene_names_refseq": "D3R; Drd3", "protein_names_uniprotkb": "D(3) dopamine receptor; Dopamine D3 receptor", "protein_names_refseq": "D(3) dopamine receptor; dopamine D3 receptor; dopamine receptor 3", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); nicotine dependence (Disease Ontology:DOID:0050742); absence epilepsy (Disease Ontology:DOID:0070309); Parkinsonism (Disease Ontology:DOID:0080855); essential tremor 1 (Disease Ontology:DOID:0111428); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13490); (R-MMU-390651); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;31626970;40523512;7598803;8449953", "class_list": "", "function": "Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions. Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior. Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels. Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders. Promotes cell proliferation through MAP kinase signaling. Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade. Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0019904 protein domain specific binding;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0034776 response to histamine;GO:0046717 acid secretion;GO:0050709 negative regulation of protein secretion;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0060160 negative regulation of dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30728-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43300-1", "uniprot_id": [ { "id": "EGR3_MOUSE", "url": "https://www.uniprot.org/uniprot/P43300", "type": "external" } ], "mass": 42635.0, "length": 387, "protein_name": "Early growth response protein 3", "gene_name": "Egr3", "organism": "Mouse", "refseq_name": "early growth response protein 3 isoform 1", "refseq_ac": [ { "id": "NP_061251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061251", "type": "external" } ], "gene_names_uniprotkb": "Egr3; Egr-3", "gene_names_refseq": "EGR-3; Egr3; Pilot", "protein_names_uniprotkb": "Early growth response protein 3; EGR-3", "protein_names_refseq": "early growth response protein 3 isoform 1; early growth response protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:13655)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1906159;32848054;34428180;37828378;38970508;40885482;9731539", "class_list": "", "function": "EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway., [RefSeq, PubMed]; Probable transcription factor involved in muscle spindle development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9R276", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007274 neuromuscular synaptic transmission;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P43300-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56931-1", "uniprot_id": [ { "id": "E2F2_MOUSE", "url": "https://www.uniprot.org/uniprot/P56931", "type": "external" } ], "mass": 48499.0, "length": 443, "protein_name": "Transcription factor E2F2", "gene_name": "E2f2", "organism": "Mouse", "refseq_name": "transcription factor E2F2 isoform 2", "refseq_ac": [ { "id": "NP_001292328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292328", "type": "external" } ], "gene_names_uniprotkb": "E2f2", "gene_names_refseq": "E2F-2; E2f2", "protein_names_uniprotkb": "Transcription factor E2F2; E2F-2", "protein_names_refseq": "transcription factor E2F2 isoform 2; transcription factor E2F2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:242705); (R-MMU-69231)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15716352;38152068;38771044;9149906;9376316", "class_list": "", "function": "A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter., [RefSeq, PubMed]; DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AW43;Q8BID0", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:1990086 lens fiber cell apoptotic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56931-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03963-1", "uniprot_id": [ { "id": "E2AK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03963", "type": "external" } ], "mass": 58280.0, "length": 515, "protein_name": "Interferon-induced, double-stranded RNA-activated protein kinase", "gene_name": "Eif2ak2", "organism": "Mouse", "refseq_name": "interferon-induced, double-stranded RNA-activated protein kinase", "refseq_ac": [ { "id": "NP_035293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035293", "type": "external" } ], "gene_names_uniprotkb": "Eif2ak2; Pkr; Prkr; Tik", "gene_names_refseq": "2310047A08Rik; 4732414G15Rik; Eif2ak2; Pkr; Prkr; Tik", "protein_names_uniprotkb": "Interferon-induced, double-stranded RNA-activated protein kinase; 2.7.10.2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; PKR; Protein kinase RNA-activated; Protein kinase R; Serine/threonine-protein kinase TIK; Tyrosine-protein kinase EIF2AK2; eIF-2A protein kinase 2; p68 kinase", "protein_names_refseq": "IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; P1/eIF-2A protein kinase; T-cell viral integration site; dsRNA-activated kinase; eIF-2 alpha; eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; p68 kinase; protein kinase RNA-activated; protein kinase, interferon-inducible double stranded RNA dependent; serine/threonine-protein kinase TIK; tyrosine-protein kinase EIF2AK2", "tax_id": 10090, "disease": "dystonia 33 (Disease Ontology:DOID:0060940); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); hepatitis B (Disease Ontology:DOID:2043); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pulmonary venoocclusive disease (Disease Ontology:DOID:5453)", "pathway": " (mmu:19106); (R-MMU-1169408); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "10848580;12882984;1351683;17079286;1714905;19229320;19264662;20038207;20478537;20585572;20631127;21123651;21300116;21994357;22633459;22801494;22948222;23229543;23392680;23401008;23403623;25428506;28135057;30084848;30779550;31219806;34428180;36210013;7533117;7914700", "class_list": "", "function": "IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:20038207, PubMed:20478537, PubMed:21123651). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:20631127, PubMed:21123651). Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV) (PubMed:19264662, PubMed:20585572, PubMed:20631127, PubMed:21994357). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, and IRS1 (PubMed:19229320, PubMed:23403623). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (By similarity). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948222, PubMed:23392680). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (By similarity). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (By similarity). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (By similarity). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494, PubMed:23401008). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (PubMed:22633459)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61742;Q62026", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.5.4.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.37", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.3.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.91", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900225 regulation of NLRP3 inflammasome complex assembly;GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q03963-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBN2-1", "uniprot_id": [ { "id": "DSEL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBN2", "type": "external" } ], "mass": 138868.0, "length": 1207, "protein_name": "Dermatan-sulfate epimerase-like protein", "gene_name": "Dsel", "organism": "Mouse", "refseq_name": "dermatan-sulfate epimerase-like protein precursor", "refseq_ac": [ { "id": "NP_001074785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074785", "type": "external" } ], "gene_names_uniprotkb": "Dsel", "gene_names_refseq": "9330132E09Rik; DS-epi2; Dsel", "protein_names_uniprotkb": "Dermatan-sulfate epimerase-like protein; 5.1.-.-", "protein_names_refseq": "dermatan-sulfate epimerase-like protein precursor; dermatan-sulfate epimerase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:319901); (R-MMU-2022923)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20358601;21177331;22496542;23843960;26488883;34428180", "class_list": "glycogene", "function": "DS-epi1 deficiency results in a major reduction of iduronic acid both on cell surface and in secreted CS/DS proteoglycans and affects directional migration of aortic smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; DS-epi2-deficient mice showed no anatomical, histological or morphological abnormalities and DS-epi1 likely compensates in vivo for the loss of DS-epi2, [RefSeq, PubMed]; DSEL was selected for study in 125 patients with diaphragmatic hernias, as it is involved in the synthesis of decorin, a protein that is required for normal collagen formation and that is upregulated during myogenesis., [RefSeq, PubMed]; Data show that dermatan sulfate is completely absent in dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice. Publication Status: Online-Only, [RefSeq, PubMed]; The iduronic acid-containing structures in the developing brain are mainly produced by the actions of dermatan sulfate epimerase 2 and play crucial roles in postnatal development, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ79", "ec_number_list": [ { "id": "5.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.-.-", "type": "external" }, { "id": "5.1.3.19", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.19", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047757 chondroitin-glucuronate 5-epimerase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0050654 chondroitin sulfate proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q0VBN2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q33DR3-1", "uniprot_id": [ { "id": "DLP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q33DR3", "type": "external" } ], "mass": 43980.0, "length": 401, "protein_name": "All trans-polyprenyl-diphosphate synthase PDSS2", "gene_name": "Pdss2", "organism": "Mouse", "refseq_name": "all trans-polyprenyl-diphosphate synthase PDSS2 isoform 2", "refseq_ac": [ { "id": "NP_001161761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161761", "type": "external" } ], "gene_names_uniprotkb": "Pdss2; Dlp1", "gene_names_refseq": "5430420P03Rik; Gm60; Pdss2; Plmp; kd; mDLP1", "protein_names_uniprotkb": "All trans-polyprenyl-diphosphate synthase PDSS2; 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 2; Decaprenyl-diphosphate synthase subunit 2; Solanesyl-diphosphate synthase subunit 2", "protein_names_refseq": "all trans-polyprenyl-diphosphate synthase PDSS2 isoform 2; all trans-polyprenyl-diphosphate synthase PDSS2; all-trans-decaprenyl-diphosphate synthase subunit 2; decaprenyl pyrophosphate synthase subunit 2; decaprenyl pyrophosphate synthetase subunit 2; decaprenyl-diphosphate synthase subunit 2; prenyltransferase-like mitochondrial protein; solanesyl-diphosphate synthase subunit 2", "tax_id": 10090, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 3 (Disease Ontology:DOID:0070240); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:71365); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16262699;18437205;21750661;21871565;22872234;25428506;30084848;31219806;31599954;34428180;36210013", "class_list": "", "function": "Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). May play a role during cerebellar development (PubMed:21871565). May regulate mitochondrial respiratory chain function (PubMed:18437205)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWA7;B2RWF3;Q3USU6;Q9D3K7", "ec_number_list": [ { "id": "2.5.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.91", "type": "external" } ], "go_molecular_function": "GO:0004659 prenyltransferase activity;GO:0097269 all-trans-decaprenyl-diphosphate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0032478 heterotetrameric polyprenyl diphosphate synthase complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0050878 regulation of body fluid levels;GO:0021549 cerebellum development;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q33DR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USS3-1", "uniprot_id": [ { "id": "DRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USS3", "type": "external" } ], "mass": 88507.0, "length": 753, "protein_name": "Dynein regulatory complex protein 1", "gene_name": "Drc1", "organism": "Mouse", "refseq_name": "dynein regulatory complex protein 1", "refseq_ac": [ { "id": "NP_001028632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028632", "type": "external" } ], "gene_names_uniprotkb": "Drc1; Ccdc164; Gm1060", "gene_names_refseq": "Ccdc164; Drc1; Gm1060; b2b1654Clo", "protein_names_uniprotkb": "Dynein regulatory complex protein 1; Coiled-coil domain-containing protein 164", "protein_names_refseq": "coiled-coil domain containing 164; coiled-coil domain-containing protein 164; dynein regulatory complex protein 1", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); spermatogenic failure 80 (Disease Ontology:DOID:0070579); primary ciliary dyskinesia 21 (Disease Ontology:DOID:0110596)", "pathway": " (mmu:381738)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;23354437;34169321;35822049", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:34169321). Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Gm1060 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EKF0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0007507 heart development;GO:0007338 single fertilization;GO:0007368 determination of left/right symmetry;GO:0035082 axoneme assembly;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3USS3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FW85-1", "uniprot_id": [ { "id": "ECM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FW85", "type": "external" } ], "mass": 76676.0, "length": 670, "protein_name": "Extracellular matrix protein 2", "gene_name": "Ecm2", "organism": "Mouse", "refseq_name": "extracellular matrix protein 2 precursor", "refseq_ac": [ { "id": "NP_001012324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012324", "type": "external" } ], "gene_names_uniprotkb": "Ecm2", "gene_names_refseq": "9030618O22Rik; Ecm2; tenonectin", "protein_names_uniprotkb": "Extracellular matrix protein 2; Tenonectin", "protein_names_refseq": "extracellular matrix protein 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:407800)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17335777;18757743", "class_list": "", "function": "Promotes matrix assembly and cell adhesiveness., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0070052 collagen V binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005614 interstitial matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FW85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4C9-1", "uniprot_id": [ { "id": "DYRK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4C9", "type": "external" } ], "mass": 66556.0, "length": 599, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "Dyrk2", "organism": "Mouse", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 2", "refseq_ac": [ { "id": "NP_001014412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014412", "type": "external" } ], "gene_names_uniprotkb": "Dyrk2", "gene_names_refseq": "1810038L18Rik; Dyrk2", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 2; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:69181); (R-MMU-6804756)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20167603;22359282;34428180;35820727", "class_list": "", "function": "Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth (By similarity). Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1 (By similarity). Can phosphorylate histone H1, histone H3 and histone H2B (in vitro) (By similarity). Can phosphorylate CARHSP1 (in vitro) (By similarity). Functions in part via its role in ubiquitin-dependent proteasomal protein degradation (By similarity). Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage (By similarity). Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity (By similarity). May play a general role in the priming of GSK3 substrates (By similarity). Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B (By similarity). Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B (By similarity). Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis (By similarity). Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1 (By similarity). Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex (By similarity). Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity (By similarity). Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation (By similarity). Acts as a positive regulator of smoothened signaling by mediating phosphorylation of GLI2 and GLI3 in response to smoothened activation, promoting their dissociation from SUFU inhibitor and translocation to the nucleus (By similarity). Can also acts as a negative regulator of smoothened by catalyzing phosphorylation of GLI2 and GLI3 and promote their proteasomal degradation (By similarity). Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2 (PubMed:22359282)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0045725 positive regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U4C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64205-1", "uniprot_id": [ { "id": "DLX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64205", "type": "external" } ], "mass": 31791.0, "length": 287, "protein_name": "Homeobox protein DLX-3", "gene_name": "Dlx3", "organism": "Mouse", "refseq_name": "homeobox protein DLX-3", "refseq_ac": [ { "id": "NP_034185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034185", "type": "external" } ], "gene_names_uniprotkb": "Dlx3", "gene_names_refseq": "Dlx-3; Dlx3", "protein_names_uniprotkb": "Homeobox protein DLX-3", "protein_names_refseq": "DII C; homeobox protein DLX-3", "tax_id": 10090, "disease": "amelogenesis imperfecta type 4 (Disease Ontology:DOID:0110053); trichodontoosseous syndrome (Disease Ontology:DOID:0111565)", "pathway": " (mmu:13393)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11343707;23371388;35922041;38825638;38945953;7893603", "class_list": "", "function": "MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis., [RefSeq, PubMed]; METTL3-mediated pre-miR-665/DLX3 m[6]A methylation facilitates the committed differentiation of stem cells from apical papilla., [RefSeq, PubMed]; Transcriptional activator (PubMed:23371388). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (PubMed:23371388)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030855 epithelial cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64205-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z23-1", "uniprot_id": [ { "id": "DYH17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z23", "type": "external" } ], "mass": 511603.0, "length": 4481, "protein_name": "Dynein axonemal heavy chain 17", "gene_name": "Dnah17", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnah17; Dnahc17; Kiaa3028", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 17; Axonemal beta dynein heavy chain 17; Ciliary dynein heavy chain 17", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 39 (Disease Ontology:DOID:0111926); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:69926)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;22872234;25428506;30059200;30084848;34105348;34203471;35820727;9373155", "class_list": "", "function": "Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of cilia (By similarity). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia. Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08820", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097228 sperm principal piece", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0036158 outer dynein arm assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q69Z23-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSF1-1", "uniprot_id": [ { "id": "DSG1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSF1", "type": "external" } ], "mass": 114454.0, "length": 1060, "protein_name": "Desmoglein-1-beta", "gene_name": "Dsg1b", "organism": "Mouse", "refseq_name": "desmoglein-1-beta preproprotein", "refseq_ac": [ { "id": "NP_859010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859010", "type": "external" } ], "gene_names_uniprotkb": "Dsg1b; Dsg5", "gene_names_refseq": "Dsg1b; Dsg5; dsg1-beta", "protein_names_uniprotkb": "Desmoglein-1-beta; Desmoglein-5; Dsg1-beta", "protein_names_refseq": "desmoglein 5; desmoglein-1-beta preproprotein", "tax_id": 10090, "disease": "keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108)", "pathway": " (mmu:225256)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12093888;12631242;12787123;16170054;24220297;30660666;34428180", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:12631242). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (PubMed:30660666). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (PubMed:30660666)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cloned and characterized a novel member of the mouse desmoglein gene family, Dsg1-beta., [RefSeq, PubMed]; Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ60", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050821 protein stabilization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TSF1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WT2-1", "uniprot_id": [ { "id": "DMRT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WT2", "type": "external" } ], "mass": 51518.0, "length": 476, "protein_name": "Doublesex- and mab-3-related transcription factor 3", "gene_name": "Dmrt3", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor 3", "refseq_ac": [ { "id": "NP_796334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796334", "type": "external" } ], "gene_names_uniprotkb": "Dmrt3", "gene_names_refseq": "Dmrt3", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 3", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:240590)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12609607;21750661;22932389;25428506;37828378", "class_list": "", "function": "Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGX1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046661 male sex differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80WT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHA3-1", "uniprot_id": [ { "id": "DTD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHA3", "type": "external" } ], "mass": 18236.0, "length": 168, "protein_name": "D-aminoacyl-tRNA deacylase 2", "gene_name": "Dtd2", "organism": "Mouse", "refseq_name": "D-aminoacyl-tRNA deacylase 2 isoform 1", "refseq_ac": [ { "id": "NP_001334333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334333", "type": "external" } ], "gene_names_uniprotkb": "Dtd2", "gene_names_refseq": "4930578F06Rik; 6530401N04Rik; ATD; B830049N13Rik; Dtd2", "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 2; 3.1.1.96; ATD; Animalia-specific tRNA deacylase; D-tyrosyl-tRNA deacylase 2; L-alanyl-tRNA deacylase", "protein_names_refseq": "D-aminoacyl-tRNA deacylase 2 isoform 1; D-aminoacyl-tRNA deacylase 2; L-alanyl-tRNA deacylase; animalia-specifc tRNA deacylase; animalia-specific tRNA deacylase; probable D-tyrosyl-tRNA(Tyr) deacylase 2; putative D-tyrosyl-tRNA deacylase 2; putative D-tyrosyl-tRNA(Tyr) deacylase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:328092)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29410408", "class_list": "", "function": "Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS. Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site. Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D363;Q9D4Q5", "ec_number_list": [ { "id": "3.1.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.96", "type": "external" } ], "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0106105 Ala-tRNA(Thr) deacylase activity;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI55-1", "uniprot_id": [ { "id": "DYRK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI55", "type": "external" } ], "mass": 72561.0, "length": 632, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 4", "gene_name": "Dyrk4", "organism": "Mouse", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 4", "refseq_ac": [ { "id": "NP_997093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997093", "type": "external" } ], "gene_names_uniprotkb": "Dyrk4", "gene_names_refseq": "Dyrk4a; Dyrk4b; Dyrk4", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 4; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:101320)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17292540;21127067;21750661;34428180", "class_list": "", "function": "DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4., [RefSeq, PubMed]; Dyrk4 is a testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids., [RefSeq, PubMed]; Possible non-essential role in spermiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WP9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BI55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLD9-1", "uniprot_id": [ { "id": "DRD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLD9", "type": "external" } ], "mass": 53076.0, "length": 478, "protein_name": "D(1B) dopamine receptor", "gene_name": "Drd5", "organism": "Mouse", "refseq_name": "D(1B) dopamine receptor", "refseq_ac": [ { "id": "NP_038531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038531", "type": "external" } ], "gene_names_uniprotkb": "Drd5", "gene_names_refseq": "D5R; Drd-5; Drd1b; Drd5; Gpcr1", "protein_names_uniprotkb": "D(1B) dopamine receptor; D(5) dopamine receptor; Dopamine D5 receptor", "protein_names_refseq": "D(1B) dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor 5", "tax_id": 10090, "disease": "pervasive developmental disorder (Disease Ontology:DOID:0060040); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); blepharospasm (Disease Ontology:DOID:529)", "pathway": " (mmu:13492); (R-MMU-390651); (R-MMU-418555)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12679517;36401517;39337509;8288218", "class_list": "", "function": "Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4[+] T-Cells to Infiltrate the Colonic Mucosa. Publication Status: Online-Only, [RefSeq, PubMed]; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase., [UniProtKB]; Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61439;Q80UB7", "ec_number_list": [], "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0035240 dopamine binding;GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007617 mating behavior;GO:0008306 associative learning;GO:0008542 visual learning;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BLD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTR5-1", "uniprot_id": [ { "id": "DUS28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTR5", "type": "external" } ], "mass": 17505.0, "length": 163, "protein_name": "Dual specificity phosphatase 28", "gene_name": "Dusp28", "organism": "Mouse", "refseq_name": "dual specificity phosphatase 28", "refseq_ac": [ { "id": "NP_780327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780327", "type": "external" } ], "gene_names_uniprotkb": "Dusp28", "gene_names_refseq": "0710001B24Rik; Dusp28", "protein_names_uniprotkb": "Dual specificity phosphatase 28; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity phosphatase 28", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)", "pathway": " (mmu:67446)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18058037", "class_list": "", "function": "Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BTR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8T7-1", "uniprot_id": [ { "id": "ELFN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8T7", "type": "external" } ], "mass": 90815.0, "length": 828, "protein_name": "Protein ELFN1", "gene_name": "Elfn1", "organism": "Mouse", "refseq_name": "protein ELFN1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_780731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780731", "type": "external" } ], "gene_names_uniprotkb": "Elfn1; Ppp1r28", "gene_names_refseq": "A930017N06Rik; Elfn1; Ppp1r28", "protein_names_uniprotkb": "Protein ELFN1; Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1; Protein phosphatase 1 regulatory subunit 28", "protein_names_refseq": "extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1; protein ELFN1 isoform 1 precursor; protein ELFN1; protein phosphatase 1 regulatory subunit 28", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:243312)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;22645316;23042292;24312227;25047565;30899004;32848054;35820727;38428819;40576023;40885482", "class_list": "", "function": "Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins. Erratum:[J Biol Chem. 2024 Oct;300(10):107782. doi: 10.1016/j.jbc.2024.107782. PMID: 39332159], [RefSeq, PubMed]; Elfn1 protein increases during postnatal development and localizes to postsynaptic sites of somatostatin-containing interneurons in the hippocampal CA1 stratum oriens and dentate gyrus hilus.Elfn1 recruits mGluR7 to synaptic sites. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation of Elfn1 in mice causes seizures and hyperactivity. Publication Status: Online-Only, [RefSeq, PubMed]; Postsynaptic expression of Elfn1 in oriens-lacunosum moleculare interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons., [RefSeq, PubMed]; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043679 axon terminus", "go_biological_process": "GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0007416 synapse assembly;GO:0007601 visual perception;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8C8T7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHY3-1", "uniprot_id": [ { "id": "DYM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHY3", "type": "external" } ], "mass": 75848.0, "length": 669, "protein_name": "Dymeclin", "gene_name": "Dym", "organism": "Mouse", "refseq_name": "dymeclin isoform 2", "refseq_ac": [ { "id": "NP_082003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082003", "type": "external" } ], "gene_names_uniprotkb": "Dym", "gene_names_refseq": "1810041M12Rik; 4933427L07Rik; C030019K18Rik; Dym", "protein_names_uniprotkb": "Dymeclin", "protein_names_refseq": "dymeclin isoform 2", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Smith-McCort dysplasia 1 (Disease Ontology:DOID:0081270); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:69190)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20173027;21750661;25652408;34428180;37944732", "class_list": "", "function": "CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression., [RefSeq, PubMed]; Dymeclin is crucial for proper myelination and anterograde neuronal trafficking, two processes that are highly active during postnatal brain maturation., [RefSeq, PubMed]; Necessary for correct organization of Golgi apparatus. Involved in bone development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3F3;Q3UDW2;Q569W1;Q8C7M2;Q8VCZ4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0060348 bone development;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHY3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0D5-1", "uniprot_id": [ { "id": "EFGM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0D5", "type": "external" } ], "mass": 83550.0, "length": 751, "protein_name": "Elongation factor G, mitochondrial", "gene_name": "Gfm1", "organism": "Mouse", "refseq_name": "elongation factor G, mitochondrial", "refseq_ac": [ { "id": "NP_613057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613057", "type": "external" } ], "gene_names_uniprotkb": "Gfm1; Efg1; Efg; Gfm", "gene_names_refseq": "D3Wsu133e; Gfm1; Gfm", "protein_names_uniprotkb": "Elongation factor G, mitochondrial; 3.6.5.-; EF-Gmt; Elongation factor G 1, mitochondrial; Elongation factor G1; mEF-G 1", "protein_names_refseq": "EF-Gmt; G elongation factor 1; elongation factor G 1, mitochondrial; elongation factor G, mitochondrial; elongation factor G1; mEF-G 1", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 1 (Disease Ontology:DOID:0111474)", "pathway": " (mmu:28030); (R-MMU-5389840)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11374907;31219806;34919756;39927985", "class_list": "", "function": "Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations., [RefSeq, PubMed]; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921D6;Q924I0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070125 mitochondrial translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K0D5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WN1-1", "uniprot_id": [ { "id": "DNJC9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WN1", "type": "external" } ], "mass": 30059.0, "length": 259, "protein_name": "DnaJ homolog subfamily C member 9", "gene_name": "Dnajc9", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 9", "refseq_ac": [ { "id": "NP_598842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598842", "type": "external" } ], "gene_names_uniprotkb": "Dnajc9", "gene_names_refseq": "5330419I01Rik; Dnajc9", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 9", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 9; dnaJ homolog subfamily C member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:108671)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;29187734;34428180", "class_list": "", "function": "Acts as a dual histone chaperone and heat shock co-chaperone (By similarity). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (By similarity). May also act as a histone co-chaperone together with TONSL (By similarity). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (By similarity). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (By similarity). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (By similarity). Exhibits activity to assemble histones onto DNA in vitro (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSG3;Q8R0E3", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0032781 positive regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91WN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YE2-1", "uniprot_id": [ { "id": "EGLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YE2", "type": "external" } ], "mass": 45109.0, "length": 419, "protein_name": "Prolyl hydroxylase EGLN2", "gene_name": "Egln2", "organism": "Mouse", "refseq_name": "prolyl hydroxylase EGLN2 isoform 1", "refseq_ac": [ { "id": "NP_444438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444438", "type": "external" } ], "gene_names_uniprotkb": "Egln2", "gene_names_refseq": "0610011A13Rik; Egln2; Hif-p4h-1; Ier4; Phd1; SM-20", "protein_names_uniprotkb": "Prolyl hydroxylase EGLN2; 1.14.11.-; 1.14.11.29; Egl nine homolog 2; Falkor; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; Hypoxia-inducible factor prolyl hydroxylase 1; PHD1; Prolyl hydroxylase domain-containing protein 1", "protein_names_refseq": "HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; falkor; hypoxia-inducible factor prolyl hydroxylase 1; immediate early response 4; prolyl hydroxylase EGLN2 isoform 1; prolyl hydroxylase EGLN2; prolyl hydroxylase domain-containing protein 1", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:112406); (R-MMU-1234176)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11574160;12234095;12360397;18176562;19587290;21083501;24809345;32782141;36852467;37847687", "class_list": "", "function": "Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension., [RefSeq, PubMed]; Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:24809345). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also hydroxylates HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:18176562, PubMed:19587290, PubMed:21083501). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:18176562, PubMed:19587290, PubMed:21083501). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:18176562, PubMed:19587290, PubMed:21083501). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (PubMed:24809345)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6I4;Q8CIL9;Q8VHJ1;Q99MI0", "ec_number_list": [ { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0031545 peptidyl-proline 4-dioxygenase activity;GO:0019826 oxygen sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0045454 cell redox homeostasis;GO:0045732 positive regulation of protein catabolic process;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91YE2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ46-1", "uniprot_id": [ { "id": "DRC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ46", "type": "external" } ], "mass": 18929.0, "length": 164, "protein_name": "Dynein regulatory complex protein 8", "gene_name": "Drc8", "organism": "Mouse", "refseq_name": "dynein regulatory complex protein 8", "refseq_ac": [ { "id": "NP_080902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080902", "type": "external" } ], "gene_names_uniprotkb": "Drc8; Efcab2", "gene_names_refseq": "1700073K01Rik; D830011E08Rik; Drc8; Efcab2", "protein_names_uniprotkb": "Dynein regulatory complex protein 8; EF-hand calcium-binding domain-containing protein 2", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 2; dynein regulatory complex protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:68226)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30933994", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB]; EFCAB2 is a novel calcium-binding protein in mouse testis and sperm. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS07", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0097228 sperm principal piece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWH0-1", "uniprot_id": [ { "id": "DPPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWH0", "type": "external" } ], "mass": 34116.0, "length": 301, "protein_name": "Developmental pluripotency-associated protein 2", "gene_name": "Dppa2", "organism": "Mouse", "refseq_name": "developmental pluripotency-associated protein 2", "refseq_ac": [ { "id": "NP_082891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082891", "type": "external" } ], "gene_names_uniprotkb": "Dppa2; Phsecrg1", "gene_names_refseq": "2410088E07Rik; D19Mgi18; Dppa2; ECAT15-2", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 2; ECAT15-2; Embryonic stem cell-associated transcript 15-2 protein; Pluripotent embryonic stem cell-related gene 1 protein", "protein_names_refseq": "developmental pluripotency-associated protein 2; embryonic stem cell-associated transcript 15-2 protein; pluripotent embryonic stem cell-related gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73703)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12620990;15583978;16990585;19846433;21896782;32572256;33316032;34428180;34878123;34931676", "class_list": "", "function": "Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes., [UniProtKB, PubMed]; DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development., [RefSeq, PubMed]; Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development., [RefSeq, PubMed]; Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region., [RefSeq, PubMed]; Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival., [RefSeq, PubMed]; Results showed that the expression of Dppa2 decreased markedly in differentiated cells. Dppa2 might play a role in maintenance of the undifferentiated state and proliferation of ES cells Erratum:[J Biochem. 2010 Jun;147(6):929], [RefSeq, PubMed]; Study of expression and function of pluripotent markers such as Dppa2 and Dppa4 is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048731 system development;GO:2000648 positive regulation of stem cell proliferation;GO:0006351 DNA-templated transcription;GO:0019827 stem cell population maintenance;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CWH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJF6-1", "uniprot_id": [ { "id": "EFCC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJF6", "type": "external" } ], "mass": 61881.0, "length": 558, "protein_name": "EF-hand and coiled-coil domain-containing protein 1", "gene_name": "Efcc1", "organism": "Mouse", "refseq_name": "EF-hand and coiled-coil domain-containing protein 1", "refseq_ac": [ { "id": "NP_001153169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153169", "type": "external" } ], "gene_names_uniprotkb": "Efcc1; Ccdc48; MNCb-4779", "gene_names_refseq": "Ccdc48; Efcc1", "protein_names_uniprotkb": "EF-hand and coiled-coil domain-containing protein 1; Coiled-coil domain-containing protein 48", "protein_names_refseq": "EF-hand and coiled-coil domain-containing protein 1; EF-hand domain-containing protein ENSP00000381169 homolog; coiled-coil domain containing 48; coiled-coil domain-containing protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:58229)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ5-1", "uniprot_id": [ { "id": "EGFL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJZ5", "type": "external" } ], "mass": 61520.0, "length": 550, "protein_name": "Epidermal growth factor-like protein 6", "gene_name": "Egfl6", "organism": "Mouse", "refseq_name": "epidermal growth factor-like protein 6 precursor", "refseq_ac": [ { "id": "NP_062270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062270", "type": "external" } ], "gene_names_uniprotkb": "Egfl6; Maeg", "gene_names_refseq": "Egfl6; Maeg", "protein_names_uniprotkb": "Epidermal growth factor-like protein 6; EGF-like protein 6; MAM and EGF domains-containing gene protein; Protein W80", "protein_names_refseq": "EGF-like protein 6; MAM and EGF domains-containing gene protein; epidermal growth factor-like protein 6 precursor; epidermal growth factor-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:54156)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10777661;11044626;15572035;18757743;34815781;35820727", "class_list": "", "function": "MAEG may play a role as a mediator regulating epithelial-mesenchymal interaction through binding to RGD-binding integrins including alpha8beta1 during hair follicle development., [RefSeq, PubMed]; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly., [UniProtKB, PubMed, PubMed]; Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPM8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJZ5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R187-1", "uniprot_id": [ { "id": "EDAR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R187", "type": "external" } ], "mass": 48434.0, "length": 448, "protein_name": "Tumor necrosis factor receptor superfamily member EDAR", "gene_name": "Edar", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member EDAR isoform 1 precursor", "refseq_ac": [ { "id": "NP_034230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034230", "type": "external" } ], "gene_names_uniprotkb": "Edar; Dl", "gene_names_refseq": "ED1R; ED3; ED5; EDA-A1R; EDA3; Edar; dl", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; Downless; Ectodermal dysplasia receptor; Ectodysplasin-A receptor", "protein_names_refseq": "anhidrotic ectodysplasin receptor 1; downless; ectodermal dysplasia receptor; tumor necrosis factor receptor superfamily member EDAR isoform 1 precursor; tumor necrosis factor receptor superfamily member EDAR", "tax_id": 10090, "disease": "ectodermal dysplasia 10A (Disease Ontology:DOID:0111663); ectodermal dysplasia 10B (Disease Ontology:DOID:0111665); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793)", "pathway": " (mmu:13608); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10431242;11203701", "class_list": "", "function": "Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC43", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0046330 positive regulation of JNK cascade;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R187-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2U4-1", "uniprot_id": [ { "id": "ELF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2U4", "type": "external" } ], "mass": 70800.0, "length": 655, "protein_name": "ETS-related transcription factor Elf-4", "gene_name": "Elf4", "organism": "Mouse", "refseq_name": "ETS-related transcription factor Elf-4", "refseq_ac": [ { "id": "NP_062654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062654", "type": "external" } ], "gene_names_uniprotkb": "Elf4; Mef", "gene_names_refseq": "Elf4; Gm9907; Mef", "protein_names_uniprotkb": "ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor", "protein_names_refseq": "E74-like factor 4 (ets domain transcription factor); E74-like factor 4; ETS-related transcription factor Elf-4; myeloid elf-1 like factor; myeloid elf-1-like factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56501)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12387738;17167770;19380490;19412182;19892989;20173027;20484733;25428506;25605945;27802388;30084848;30779550;31219806;34326534;34428180;35266071;36477361;38022496;38334823", "class_list": "", "function": "An ELF4 hypomorphic variant results in NK cell deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; MEF-/- mice have a profound reduction in the number of NK-T and NK cells, [RefSeq, PubMed]; The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that MEF promotes cell proliferation and functions as a negative regulator of osteogenic differentiation by directly interacting with Runx2 and suppressing its transcriptional activity., [RefSeq, PubMed]; Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (PubMed:34326534, PubMed:35266071)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; White adipocyte-derived exosomal miR-23b inhibits thermogenesis by targeting Elf4 to regulate GLP-1R transcription., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AY67", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032691 negative regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z2U4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTT6-1", "uniprot_id": [ { "id": "UTP25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTT6", "type": "external" } ], "mass": 88818.0, "length": 772, "protein_name": "U3 small nucleolar RNA-associated protein 25 homolog", "gene_name": "Utp25", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 25 homolog isoform 1", "refseq_ac": [ { "id": "NP_663390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663390", "type": "external" } ], "gene_names_uniprotkb": "Utp25; Def; Diexf", "gene_names_refseq": "Def; Diexf; Utp25; mDef", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 25 homolog; Digestive organ expansion factor homolog; UTP25 small subunit processor component", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 25 homolog isoform 1; U3 small nucleolar RNA-associated protein 25 homolog; UTP25 small subunit processor component; digestive-organ expansion factor homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:215193); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25605945;29262616;31219806;32303961;34428180", "class_list": "", "function": "Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:29262616, PubMed:32303961). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWJ1;Q8VEC2", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0040019 positive regulation of embryonic development;GO:0030163 protein catabolic process;GO:0031648 protein destabilization;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BTT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925U4-1", "uniprot_id": [ { "id": "EDEM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925U4", "type": "external" } ], "mass": 73701.0, "length": 652, "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 1", "gene_name": "Edem1", "organism": "Mouse", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 1", "refseq_ac": [ { "id": "NP_619618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619618", "type": "external" } ], "gene_names_uniprotkb": "Edem1; Edem", "gene_names_refseq": "A130059K23Rik; EDEM; Edem1; mKIAA0212", "protein_names_uniprotkb": "ER degradation-enhancing alpha-mannosidase-like protein 1", "protein_names_refseq": "ER degradation ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; ER degradation-enhancing alpha-mannosidase-like protein 1", "tax_id": 10090, "disease": "cystic fibrosis (Disease Ontology:DOID:1485)", "pathway": " (mmu:192193)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11375934;15215312;18653895;21329881;21750661;25428506;30084848;30779550;31219806;34203471;34428180;35820727", "class_list": "glycogene;glycosylhydrolase", "function": "Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Role of the lectins Htm1p/EDEM in the degradation process of CFTR, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFM1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0051787 misfolded protein binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0016235 aggresome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:1904154 positive regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q925U4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32M08-1", "uniprot_id": [ { "id": "DUS4L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32M08", "type": "external" } ], "mass": 36620.0, "length": 324, "protein_name": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like", "gene_name": "Dus4l", "organism": "Mouse", "refseq_name": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 1", "refseq_ac": [ { "id": "NP_082278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082278", "type": "external" } ], "gene_names_uniprotkb": "Dus4l", "gene_names_refseq": "2310069P03Rik; 2700089B10Rik; Dus4l; Pp35", "protein_names_uniprotkb": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; 1.3.1.90; tRNA-dihydrouridine synthase 4-like", "protein_names_refseq": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71916)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6P4", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "1.3.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.90", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0102266 tRNA-dihydrouridine20a synthase activity;GO:0102267 tRNA-dihydrouridine20b synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32M08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFV3-1", "uniprot_id": [ { "id": "DUS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFV3", "type": "external" } ], "mass": 43372.0, "length": 398, "protein_name": "Dual specificity protein phosphatase 4", "gene_name": "Dusp4", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 4 isoform 1", "refseq_ac": [ { "id": "NP_795907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795907", "type": "external" } ], "gene_names_uniprotkb": "Dusp4", "gene_names_refseq": "2700078F24Rik; Dusp4; E130306H24Rik; MKP2", "protein_names_uniprotkb": "Dual specificity protein phosphatase 4; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 4 isoform 1; dual specificity protein phosphatase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:319520); (R-MMU-112409); (R-MMU-202670); (R-MMU-5675221)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "17452331;19224205;20173027;25428506;30084848;30779550;31219806;34203471;34428180;35820727;38383887", "class_list": "", "function": "DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response., [RefSeq, PubMed]; E2F-1 is a transcriptional activator of MKP-2 and MKP-2 is an essential cell death mediator in the E2F-1 pathway, [RefSeq, PubMed]; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0051019 mitogen-activated protein kinase binding;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BFV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0K9-1", "uniprot_id": [ { "id": "E2F4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0K9", "type": "external" } ], "mass": 43833.0, "length": 410, "protein_name": "Transcription factor E2F4", "gene_name": "E2f4", "organism": "Mouse", "refseq_name": "transcription factor E2F4", "refseq_ac": [ { "id": "NP_683754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683754", "type": "external" } ], "gene_names_uniprotkb": "E2f4", "gene_names_refseq": "2010111M04Rik; E2f4", "protein_names_uniprotkb": "Transcription factor E2F4; E2F-4", "protein_names_refseq": "E2F-4; transcription factor E2F4", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:104394); (R-MMU-1538133); (R-MMU-2173796); (R-MMU-69231)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17383628;21183079;35023014;35254651;39043964", "class_list": "", "function": "A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice., [RefSeq, PubMed]; In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis., [RefSeq, PubMed]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2X6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R0K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHE6-1", "uniprot_id": [ { "id": "DYH5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHE6", "type": "external" } ], "mass": 527558.0, "length": 4621, "protein_name": "Dynein axonemal heavy chain 5", "gene_name": "Dnah5", "organism": "Mouse", "refseq_name": "dynein axonemal heavy chain 5", "refseq_ac": [ { "id": "NP_579943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579943", "type": "external" } ], "gene_names_uniprotkb": "Dnah5; Dnahc5", "gene_names_refseq": "Dnah5; Dnahc5; Mdnah5; b2b1134Clo; b2b1154Clo; b2b1537Clo; b2b1565Clo; b2b3491Clo; b2b601Clo; mKIAA1603", "protein_names_uniprotkb": "Dynein axonemal heavy chain 5; Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5; mDNAH5", "protein_names_refseq": "axonemal beta dynein heavy chain 5; axonemal dynein heavy chain 5; ciliary dynein heavy chain 5; dynein axonemal heavy chain 5; dynein heavy chain 5, axonemal; dynein, axon, heavy chain 5", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 3 (Disease Ontology:DOID:0110599); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); tetralogy of Fallot (Disease Ontology:DOID:6419); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:110082)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11788826;11912187;15269178;33347437;34418053;34428180;35820727", "class_list": "", "function": "Force generating protein of respiratory cilia (PubMed:15269178). Produces force towards the minus ends of microtubules (PubMed:15269178). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (PubMed:15269178). Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (PubMed:15269178)., [UniProtKB, PubMed, UniProtKB]; Loss of function of Mdnah5 causes primary ciliary dyskinesia and hydrocephalus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKD7;Q8BWG1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VHE6-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZJ9-1", "uniprot_id": [ { "id": "DJC18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZJ9", "type": "external" } ], "mass": 41434.0, "length": 357, "protein_name": "DnaJ homolog subfamily C member 18", "gene_name": "Dnajc18", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 18", "refseq_ac": [ { "id": "NP_083945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083945", "type": "external" } ], "gene_names_uniprotkb": "Dnajc18", "gene_names_refseq": "2700075B01Rik; Dnajc18", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 18", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 18; dnaJ homolog subfamily C member 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:76594)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R371", "ec_number_list": [], "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9D8-1", "uniprot_id": [ { "id": "DUS21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9D8", "type": "external" } ], "mass": 21509.0, "length": 189, "protein_name": "Dual specificity phosphatase 21", "gene_name": "Dusp21", "organism": "Mouse", "refseq_name": "dual specificity phosphatase 21", "refseq_ac": [ { "id": "NP_082844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082844", "type": "external" } ], "gene_names_uniprotkb": "Dusp21", "gene_names_refseq": "1700094E07Rik; DSP21; Dusp21", "protein_names_uniprotkb": "Dual specificity phosphatase 21; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity phosphatase 21; novel dual specificity phosphatase, catalytic domain containing protein", "tax_id": 10090, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)", "pathway": " (mmu:73547)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18385140;31219806;37295417;37989994", "class_list": "", "function": "Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane, [RefSeq, PubMed]; Protein phosphatase component of the sperm flagellar doublet microtubules (PubMed:37295417, PubMed:37989994). May act as a regulator of sperm motility by mediating dephosphorylation of sperm doublet microtubule proteins (PubMed:37295417). Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine (PubMed:18385140)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0006612 protein targeting to membrane;GO:0030317 flagellated sperm motility;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D9D8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYZ8-1", "uniprot_id": [ { "id": "DKK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYZ8", "type": "external" } ], "mass": 28432.0, "length": 259, "protein_name": "Dickkopf-related protein 2", "gene_name": "Dkk2", "organism": "Mouse", "refseq_name": "dickkopf-related protein 2 precursor", "refseq_ac": [ { "id": "NP_064661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064661", "type": "external" } ], "gene_names_uniprotkb": "Dkk2", "gene_names_refseq": "Dkk2", "protein_names_uniprotkb": "Dickkopf-related protein 2; Dickkopf-2; Dkk-2; mDkk-2", "protein_names_refseq": "dickkopf 2; dickkopf homolog 1; dickkopf homolog 2; dickkopf-related protein 2 precursor; dickkopf-related protein 2; dkk-2; mDkk-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56811); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10495270;17143291;18524778;27550540;27713059;38945954", "class_list": "", "function": "Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease., [UniProtKB, PubMed]; Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFW0", "ec_number_list": [], "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QYZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z188-1", "uniprot_id": [ { "id": "DYR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z188", "type": "external" } ], "mass": 69178.0, "length": 629, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 1B", "gene_name": "Dyrk1b", "organism": "Mouse", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69", "refseq_ac": [ { "id": "NP_001033046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033046", "type": "external" } ], "gene_names_uniprotkb": "Dyrk1b", "gene_names_refseq": "Dyrk1b; Mirk", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 1B; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); abdominal obesity-metabolic syndrome 3 (Disease Ontology:DOID:0060612); intellectual disability (Disease Ontology:DOID:1059); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:13549)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12384504;12633499;12902328;22645316;26495903;32848054;34855620;35235343;35822049;37120440;38834297;40885482;9918863", "class_list": "", "function": "DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics., [RefSeq, PubMed]; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:12633499). Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1)., [UniProtKB, UniProtKB, PubMed]; Dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation, [RefSeq, PubMed]; Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice., [RefSeq, PubMed]; Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response. Publication Status: Online-Only, [RefSeq, PubMed]; P38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFR5;Q70UR5;Q9EPM2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0060612 adipose tissue development;GO:0045893 positive regulation of DNA-templated transcription;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z188-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1G0-1", "uniprot_id": [ { "id": "FCG3A_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1G0", "type": "external" } ], "mass": 28398.0, "length": 249, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor III-A", "gene_name": "Fcgr4", "organism": "Mouse", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor III-A precursor", "refseq_ac": [ { "id": "NP_653142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653142", "type": "external" } ], "gene_names_uniprotkb": "Fcgr4; Fcgr3a", "gene_names_refseq": "4833442P21Rik; CD16-2; FcgRIV; FcgammaRIV; Fcgr3a; Fcgr4; Fcrl3", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor III-A; CD16-2; FcgammaRIV; IgG Fc receptor III-A", "protein_names_refseq": "Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; IgG Fc receptor III-A; low affinity immunoglobulin gamma Fc region receptor III-A precursor; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor IV", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); lupus nephritis (Disease Ontology:DOID:0080162); graft-versus-host disease (Disease Ontology:DOID:0081267); immunodeficiency 20 (Disease Ontology:DOID:0111941); allergic disease (Disease Ontology:DOID:1205); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); polyneuropathy (Disease Ontology:DOID:1389); thrombocytopenia due to platelet alloimmunization (Disease Ontology:DOID:1587); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); lymphopenia (Disease Ontology:DOID:614); myositis (Disease Ontology:DOID:633); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); Crohn's disease (Disease Ontology:DOID:8778); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:246256); (R-MMU-163125); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12389094;16039578;16709862;17558411;18097064;18292508;18949059;19144319;19795417;24412922;25824719;28389502;28935714;34428180;34485821", "class_list": "", "function": "Fc gammaRIV (Fc fragment of IgG, low affinity IIIa, receptor) is restricted to myeloid lineage cells, and binds to IgG2a and IgG2b with intermediate affinity., [RefSeq, PubMed]; Identification of its gene, [RefSeq, PubMed]; Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (PubMed:24412922). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed:28389502). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed:17558411, PubMed:18949059). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The length of the stalk region of the alpha-chain is an important determinant of Fc gamma receptor IIIA stability on the cell surface., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC44;Q8R2R4;Q8R477", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0033001 Fc-gamma receptor III complex", "go_biological_process": "GO:0002468 dendritic cell antigen processing and presentation;GO:0007166 cell surface receptor signaling pathway;GO:0045780 positive regulation of bone resorption;GO:0071222 cellular response to lipopolysaccharide;GO:0042119 neutrophil activation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "A0A0B4J1G0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26151-1", "uniprot_id": [ { "id": "FCGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P26151", "type": "external" } ], "mass": 44888.0, "length": 404, "protein_name": "High affinity immunoglobulin gamma Fc receptor I", "gene_name": "Fcgr1", "organism": "Mouse", "refseq_name": "high affinity immunoglobulin gamma Fc receptor I precursor", "refseq_ac": [ { "id": "NP_034316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034316", "type": "external" } ], "gene_names_uniprotkb": "Fcgr1; Fcg1", "gene_names_refseq": "CD64; FcgammaRI; Fcgr1; IGGHAFC", "protein_names_uniprotkb": "High affinity immunoglobulin gamma Fc receptor I; Fc-gamma RI; FcRI; IgG Fc receptor I", "protein_names_refseq": "IgG high affinity Fc receptor; fc-gamma RI; fcRI; high affinity immunoglobulin gamma Fc receptor I precursor; high affinity immunoglobulin gamma Fc receptor I; igG Fc receptor I", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:14129); (R-MMU-1236978); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11911823;11911824;1531670;19144319;2136886;21750661;34428180;8478020", "class_list": "", "function": "High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9868, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019864 IgG binding;GO:0031774 leukotriene receptor binding;GO:0019770 IgG receptor activity;GO:0019771 high-affinity IgG receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0006911 phagocytosis, engulfment;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26151-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR98-1", "uniprot_id": [ { "id": "TIMCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR98", "type": "external" } ], "mass": 15674.0, "length": 138, "protein_name": "TIM double twin CX3C motif protein", "gene_name": "Fam136a; Timcc", "organism": "Mouse", "refseq_name": "protein FAM136A isoform 1", "refseq_ac": [ { "id": "NP_079867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079867", "type": "external" } ], "gene_names_uniprotkb": "Fam136a; Timcc; Fam136a", "gene_names_refseq": "2010309E21Rik; Fam136a; Hyccin; Timcc", "protein_names_uniprotkb": "TIM double twin CX3C motif protein", "protein_names_refseq": "family with sequence similarity 136, member A; protein FAM136A isoform 1; protein FAM136A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66488)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;37461313;40714634", "class_list": "", "function": "Plays a role in proteostasis of the mitochondrion intermembrane space and counteracts aggregation of certain proteins. Required for mitochondrial oxidative phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YY1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZN3-1", "uniprot_id": [ { "id": "FBX8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZN3", "type": "external" } ], "mass": 36970.0, "length": 319, "protein_name": "F-box only protein 8", "gene_name": "Fbxo8", "organism": "Mouse", "refseq_name": "F-box only protein 8 isoform 1", "refseq_ac": [ { "id": "NP_056606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056606", "type": "external" } ], "gene_names_uniprotkb": "Fbxo8; Fbx8", "gene_names_refseq": "Fbx8; Fbxo8", "protein_names_uniprotkb": "F-box only protein 8", "protein_names_refseq": "F-box only protein 8 isoform 1; F-box only protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:50753)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10531037;18094045;21750661", "class_list": "", "function": "Fbx8, an F-box protein bearing the Sec7 domain, mediates ubiquitination of Arf6., [RefSeq, PubMed]; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZY7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI71-1", "uniprot_id": [ { "id": "EX3L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI71", "type": "external" } ], "mass": 81204.0, "length": 739, "protein_name": "Exocyst complex component 3-like protein", "gene_name": "Exoc3l1; Exoc3l", "organism": "Mouse", "refseq_name": "exocyst complex component 3-like protein isoform 1", "refseq_ac": [ { "id": "NP_808456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808456", "type": "external" } ], "gene_names_uniprotkb": "Exoc3l1; Exoc3l; Exoc3l", "gene_names_refseq": "C730015A04Rik; Exoc3l1; Exoc3l", "protein_names_uniprotkb": "Exocyst complex component 3-like protein", "protein_names_refseq": "exocyst complex component 3-like protein isoform 1; exocyst complex component 3-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:277978)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18480549;21750661;30084848;30779550;34428180;37661429", "class_list": "", "function": "As part of the exocyst, may play a role in regulated exocytosis of insulin granules., [UniProtKB, PubMed]; Null mutation of exocyst complex component 3-like does not affect vascular development in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3USB8", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0030141 secretory granule;GO:0030133 transport vesicle;GO:0000145 exocyst", "go_biological_process": "GO:0051601 exocyst localization;GO:0006887 exocytosis;GO:0030072 peptide hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BI71-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AW46-1", "uniprot_id": [ { "id": "EST5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6AW46", "type": "external" } ], "mass": 64167.0, "length": 575, "protein_name": "Carboxylesterase 5A", "gene_name": "Ces5a", "organism": "Mouse", "refseq_name": "carboxylesterase 5A isoform 2 precursor", "refseq_ac": [ { "id": "NP_001003951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003951", "type": "external" } ], "gene_names_uniprotkb": "Ces5a; Ces7", "gene_names_refseq": "1700081L16Rik; 1700122C07Rik; Ces5a; Ces7; Gm503; cauxin", "protein_names_uniprotkb": "Carboxylesterase 5A; 3.1.1.1; Carboxylesterase-like urinary excreted protein homolog; Cauxin", "protein_names_refseq": "carboxylesterase 5A isoform 2 precursor; carboxylesterase 7; carboxylesterase-like urinary excreted protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67935)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17045831;21750661", "class_list": "glycogene", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.67", "type": "external" } ], "go_molecular_function": "GO:0106435 carboxylesterase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AW46-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AKG8-1", "uniprot_id": [ { "id": "FOCAD_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AKG8", "type": "external" } ], "mass": 198950.0, "length": 1798, "protein_name": "Focadhesin", "gene_name": "Focad", "organism": "Mouse", "refseq_name": "focadhesin isoform 1", "refseq_ac": [ { "id": "NP_001074653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074653", "type": "external" } ], "gene_names_uniprotkb": "Focad; BC057079; Kiaa1797", "gene_names_refseq": "Focad", "protein_names_uniprotkb": "Focadhesin", "protein_names_refseq": "focadhesin isoform 1", "tax_id": 10090, "disease": "liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:230393)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22427331;30084848;31219806;31599954;35820727;37828378", "class_list": "", "function": "Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex (By similarity). Potential tumor suppressor in gliomas., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0P620;Q3TPY9;Q3UJY8;Q3UK73;Q6PGE3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0060147 regulation of post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2AKG8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35242-1", "uniprot_id": [ { "id": "FAN_MOUSE", "url": "https://www.uniprot.org/uniprot/O35242", "type": "external" } ], "mass": 104546.0, "length": 920, "protein_name": "Protein FAN", "gene_name": "Nsmaf", "organism": "Mouse", "refseq_name": "protein FAN isoform 1", "refseq_ac": [ { "id": "NP_035075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035075", "type": "external" } ], "gene_names_uniprotkb": "Nsmaf; Fan", "gene_names_refseq": "C630007J05; Fan; Nsmaf", "protein_names_uniprotkb": "Protein FAN; Factor associated with N-SMase activation; Factor associated with neutral sphingomyelinase activation", "protein_names_refseq": "factor associated with N-SMase activation; factor associated with neutral sphingomyelinase activation; protein FAN isoform 1; protein FAN", "tax_id": 10090, "disease": "", "pathway": " (mmu:18201); (R-MMU-5626978)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10228161;18825372;19786552;19892989;21750661;21952136;23044079;23674089;25605945;31219806;34428180;35820727", "class_list": "", "function": "Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE., [UniProtKB]; FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis., [RefSeq, PubMed]; FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor., [RefSeq, PubMed]; These results indicate the involvement of FAN in TNF-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response., [RefSeq, PubMed]; This is the first report to demonstrate that TNFalpha-induced sickness behavior is fully mediated by TNF-R1 and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKK1", "ec_number_list": [], "go_molecular_function": "GO:0016230 sphingomyelin phosphodiesterase activator activity;GO:0035591 signaling adaptor activity;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35242-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2APV2-1", "uniprot_id": [ { "id": "FMNL2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2APV2", "type": "external" } ], "mass": 123101.0, "length": 1086, "protein_name": "Formin-like protein 2", "gene_name": "Fmnl2", "organism": "Mouse", "refseq_name": "formin-like protein 2 isoform 3", "refseq_ac": [ { "id": "NP_765997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997", "type": "external" } ], "gene_names_uniprotkb": "Fmnl2; Kiaa1902; Man", "gene_names_refseq": "5430425K04Rik; Fmnl2; Man", "protein_names_uniprotkb": "Formin-like protein 2; Protein Man", "protein_names_refseq": "formin-like domain containing protein MAN; formin-like protein 2 isoform 3; formin-like protein 2; protein Man", "tax_id": 10090, "disease": "", "pathway": " (mmu:71409); (R-MMU-5663220); (R-MMU-9013106)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;16490788;18299400;19224205;20173027;21750661;21952136;2298213;25428506;25428507;25605945;26495903;26740625;28011936;28327544;28852060;30084848;30779550;33169848;34428180;35820727;37828378;38747713", "class_list": "", "function": "Caveolin-1 influences epithelial collective cell migration via FMNL2 formin., [RefSeq, PubMed]; FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Force generation in lamellipodia strongly depends on FMNL formin activity. Publication Status: Online-Only, [RefSeq, PubMed]; MDia1-FH2 has an effect on the conformation of actin filaments, [RefSeq, PubMed]; Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus. Erratum:[Sci Rep. 2019 Nov 26;9(1):18008. doi: 10.1038/s41598-019-54630-z. PMID: 31767955] Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in actin cytoskeleton dynamics and regulation of cell shape., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AQW1;Q69Z73;Q7TPA8;Q80VH6", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0098794 postsynapse", "go_biological_process": "GO:0016477 cell migration;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "A2APV2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AV25-1", "uniprot_id": [ { "id": "FBCD1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AV25", "type": "external" } ], "mass": 50602.0, "length": 459, "protein_name": "Fibrinogen C domain-containing protein 1", "gene_name": "Fibcd1", "organism": "Mouse", "refseq_name": "fibrinogen C domain-containing protein 1", "refseq_ac": [ { "id": "NP_849218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218", "type": "external" } ], "gene_names_uniprotkb": "Fibcd1", "gene_names_refseq": "Fibcd1", "protein_names_uniprotkb": "Fibrinogen C domain-containing protein 1", "protein_names_refseq": "fibrinogen C domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:98970)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31601676;35916241;36888604", "class_list": "", "function": "Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity)., [UniProtKB]; FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder., [RefSeq, PubMed]; The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; These results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9R8;Q8BJE7;Q8BL54", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AV25-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXV4-1", "uniprot_id": [ { "id": "FLVC1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXV4", "type": "external" } ], "mass": 60469.0, "length": 560, "protein_name": "Choline/ethanolamine transporter FLVCR1", "gene_name": "Flvcr1", "organism": "Mouse", "refseq_name": "choline/ethanolamine transporter FLVCR1 isoform 1", "refseq_ac": [ { "id": "NP_001074728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074728", "type": "external" } ], "gene_names_uniprotkb": "Flvcr1; Mfsd7b", "gene_names_refseq": "9630055N22Rik; FLVCR; Flvcr1; Mfsd7b", "protein_names_uniprotkb": "Choline/ethanolamine transporter FLVCR1; Feline leukemia virus subgroup C receptor-related protein 1; Feline leukemia virus subgroup C receptor; Heme transporter FLVCR1; Major facilitator superfamily domain containing 7B; Mfsd7b; SLC49A1; Solute carrier family 49 member 1", "protein_names_refseq": "choline/ethanolamine transporter FLVCR1 isoform 1; choline/ethanolamine transporter FLVCR1; feline leukemia virus subgroup C receptor-related protein 1; heme transporter FLVCR1; major facilitator superfamily domain containing 7B", "tax_id": 10090, "disease": "neurodevelopmental disorder with microcephaly, absent speech, and hypotonia (Disease Ontology:DOID:0051030); retinopathy sensory neuropathy syndrome (Disease Ontology:DOID:0061157); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:226844); (R-MMU-189451); (R-MMU-917937)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "18258918;21750661;22058337;23187127;24021674;24486949;26495903;34428180;37100056;37828378;39019006;39237990", "class_list": "", "function": "Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR, [RefSeq, PubMed]; Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus., [RefSeq, PubMed]; FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages, [RefSeq, PubMed]; Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity., [RefSeq, PubMed]; Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation., [UniProtKB, PubMed]; Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme. Publication Status: Online-Only, [RefSeq, PubMed]; Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (By similarity). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (By similarity). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (By similarity). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:18258918, PubMed:23187127). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (By similarity). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (By similarity). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (By similarity). Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed:37100056). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (By similarity). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (By similarity). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:18258918, PubMed:23187127)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity;GO:0170003 heme B transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0060323 head morphogenesis;GO:0043249 erythrocyte maturation;GO:0001701 in utero embryonic development;GO:0006839 mitochondrial transport;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B2RXV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERY9-1", "uniprot_id": [ { "id": "ERG28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERY9", "type": "external" } ], "mass": 15806.0, "length": 140, "protein_name": "Ergosterol biosynthetic protein 28 homolog", "gene_name": "Erg28", "organism": "Mouse", "refseq_name": "ergosterol biosynthetic protein 28 homolog isoform 1", "refseq_ac": [ { "id": "NP_067421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067421", "type": "external" } ], "gene_names_uniprotkb": "Erg28; 0610007P14Rik; Orf11", "gene_names_refseq": "0610007P14Rik; 1190004E09Rik; Erg28; ORF11", "protein_names_uniprotkb": "Ergosterol biosynthetic protein 28 homolog", "protein_names_refseq": "c14orf1-like protein; ergosterol biosynthetic protein 28 homolog isoform 1; ergosterol biosynthetic protein 28 homolog; probable ergosterol biosynthetic protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:58520)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10967139;21750661;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8G1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ERY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VS8-1", "uniprot_id": [ { "id": "FARP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VS8", "type": "external" } ], "mass": 121281.0, "length": 1065, "protein_name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "gene_name": "Farp2", "organism": "Mouse", "refseq_name": "FERM, ARHGEF and pleckstrin domain-containing protein 2", "refseq_ac": [ { "id": "NP_663494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663494", "type": "external" } ], "gene_names_uniprotkb": "Farp2; Kiaa0793", "gene_names_refseq": "D030026M03Rik; Farp2; Fir; mKIAA0793", "protein_names_uniprotkb": "FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM domain including RhoGEF; FERM, RhoGEF and pleckstrin domain-containing protein 2; FIR", "protein_names_refseq": "FERM domain including RhoGEF; FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227377); (R-MMU-399955); (R-MMU-9013149); (R-MMU-9958810)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12351724;12935915;16286926;17242355;20702777;21183079;21750661;23375260;23806337;30016717;32499377;34428180", "class_list": "", "function": "Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain., [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:20702777, PubMed:23375260). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QJS4;Q3TAP2;Q69ZZ0", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0033623 regulation of integrin activation;GO:0007155 cell adhesion;GO:0016322 neuron remodeling;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91VS8-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZS3-1", "uniprot_id": [ { "id": "CEP20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZS3", "type": "external" } ], "mass": 19642.0, "length": 174, "protein_name": "Centrosomal protein 20", "gene_name": "Cep20", "organism": "Mouse", "refseq_name": "centrosomal protein 20", "refseq_ac": [ { "id": "NP_079621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079621", "type": "external" } ], "gene_names_uniprotkb": "Cep20; 0610037P05Rik; Fopnl; For20", "gene_names_refseq": "0610037P05Rik; Cep20; Fopnl", "protein_names_uniprotkb": "Centrosomal protein 20; FGFR1OP N-terminal-like protein; FOP-related protein of 20 kDa; LisH domain-containing protein FOPNL", "protein_names_refseq": "FGFR1OP N-terminal-like protein; FOP-related protein of 20 kDa; Fgfr1op N-terminal like; centrosomal protein 20; lisH domain-containing protein C16orf63 homolog; lisH domain-containing protein FOPNL", "tax_id": 10090, "disease": "", "pathway": " (mmu:66086)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20551181;21750661;26643951;28694353", "class_list": "", "function": "Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity)., [UniProtKB, UniProtKB]; Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression., [UniProtKB, UniProtKB]; The results suggested that the centrosomal protein FOR20 is a new member of the microtubule-associated protein family and that it regulates the assembly and dynamics of microtubules while interacting with tubulin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIK2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031514 motile cilium;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0034453 microtubule anchoring;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CZS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CTH6-1", "uniprot_id": [ { "id": "FCF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CTH6", "type": "external" } ], "mass": 23341.0, "length": 198, "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Fcf1", "organism": "Mouse", "refseq_name": "rRNA-processing protein FCF1 homolog", "refseq_ac": [ { "id": "NP_082908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082908", "type": "external" } ], "gene_names_uniprotkb": "Fcf1", "gene_names_refseq": "1110008B24Rik; Fcf1", "protein_names_uniprotkb": "rRNA-processing protein FCF1 homolog", "protein_names_refseq": "FCF1 small subunit; rRNA-processing protein FCF1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73736); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505C6;Q8K261", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CTH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q5Z5-1", "uniprot_id": [ { "id": "FANCF_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q5Z5", "type": "external" } ], "mass": 38224.0, "length": 343, "protein_name": "Fanconi anemia group F protein", "gene_name": "Fancf", "organism": "Mouse", "refseq_name": "Fanconi anemia group F protein", "refseq_ac": [ { "id": "NP_001108559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108559", "type": "external" } ], "gene_names_uniprotkb": "Fancf", "gene_names_refseq": "A730016A17; Fancf", "protein_names_uniprotkb": "Fanconi anemia group F protein; Protein FACF", "protein_names_refseq": "Fanconi anemia group F protein", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group F (Disease Ontology:DOID:0111088); granulosa cell tumor (Disease Ontology:DOID:2999); adenocarcinoma in situ (Disease Ontology:DOID:4943); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:100040608); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19801548;21915857", "class_list": "", "function": "DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability., [UniProtKB, PubMed]; Data identify the gene encoding Fanconi F (FANCF) as an ICSBP target gene., [RefSeq, PubMed]; Our results suggest that FANCF suppresses ovarian tumourigenesis through its role in normal gonadal development, but also by maintaining genome stability, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0001541 ovarian follicle development;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q5Z5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3S6-1", "uniprot_id": [ { "id": "EXOC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3S6", "type": "external" } ], "mass": 101889.0, "length": 894, "protein_name": "Exocyst complex component 1", "gene_name": "Exoc1", "organism": "Mouse", "refseq_name": "exocyst complex component 1 isoform 2", "refseq_ac": [ { "id": "NP_001276699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276699", "type": "external" } ], "gene_names_uniprotkb": "Exoc1; Sec3l1; Sec3", "gene_names_refseq": "2810407P21Rik; A730011E05Rik; Exoc1; SEC3; Sec3l1; Sec3p", "protein_names_uniprotkb": "Exocyst complex component 1; Exocyst complex component Sec3", "protein_names_refseq": "SEC3-like 1; exocyst complex component 1 isoform 2; exocyst complex component Sec3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69940); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21750661;25428506;26346620;31219806;33300544;33973520;34428180;35820727", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ24", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0090543 Flemming body", "go_biological_process": "GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0007566 embryo implantation;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8R3S6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08575-1", "uniprot_id": [ { "id": "EYA2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08575", "type": "external" } ], "mass": 58246.0, "length": 532, "protein_name": "Protein phosphatase EYA2", "gene_name": "Eya2", "organism": "Mouse", "refseq_name": "protein phosphatase EYA2", "refseq_ac": [ { "id": "NP_001258891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258891", "type": "external" } ], "gene_names_uniprotkb": "Eya2; Eab1", "gene_names_refseq": "Eab1; Eya2", "protein_names_uniprotkb": "Protein phosphatase EYA2; 3.1.3.48; Eyes absent homolog 2", "protein_names_refseq": "eyes absent 2 homolog; eyes absent homolog 2; protein phosphatase EYA2", "tax_id": 10090, "disease": "branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614)", "pathway": " (mmu:14049); (R-MMU-5693565)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10490620;11978764;14628052;16476741;17098221;20173027;34203471;34428180;9006082;9049631;9195991", "class_list": "", "function": "Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620, PubMed:17098221). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A5S4;P97925", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004725 protein tyrosine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0014706 striated muscle tissue development;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08575-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08914-1", "uniprot_id": [ { "id": "FAAH1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08914", "type": "external" } ], "mass": 63221.0, "length": 579, "protein_name": "Fatty-acid amide hydrolase 1", "gene_name": "Faah", "organism": "Mouse", "refseq_name": "fatty-acid amide hydrolase 1", "refseq_ac": [ { "id": "NP_034303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034303", "type": "external" } ], "gene_names_uniprotkb": "Faah; Faah1", "gene_names_refseq": "Faah", "protein_names_uniprotkb": "Fatty-acid amide hydrolase 1; 3.1.1.-; 3.5.1.99; Anandamide amidohydrolase 1; Fatty acid ester hydrolase; Oleamide hydrolase 1", "protein_names_refseq": "amide hydrolase; anandamide amidohydrolase 1; fatty acid amide hydrolase protein; fatty acid ester hydrolase; fatty-acid amide hydrolase 1; oleamide hydrolase 1", "tax_id": 10090, "disease": "Parkinson's disease 1 (Disease Ontology:DOID:0060367); alcohol use disorder (Disease Ontology:DOID:1574); substance-related disorder (Disease Ontology:DOID:303); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14073); (R-MMU-2142753)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15533037;32271712;34428180;37880305;37921652;38354897;9122178;9878243", "class_list": "", "function": "Catalyzes the hydrolysis of endogenous amidated lipids like the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides such as the taurine-conjugated fatty acids (a structural class of central nervous system (CNS) metabolites), to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:15533037, PubMed:32271712). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (PubMed:32271712). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; FAAH inhibition ameliorates breast cancer in a murine model. Publication Status: Online-Only, [RefSeq, PubMed]; Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q922S0;Q9DBF5", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" }, { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0005543 phospholipid binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse;GO:0031090 organelle membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009062 fatty acid catabolic process;GO:0045471 response to ethanol;GO:0045907 positive regulation of vasoconstriction;GO:0052651 monoacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08914-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70165-1", "uniprot_id": [ { "id": "FCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70165", "type": "external" } ], "mass": 36298.0, "length": 334, "protein_name": "Ficolin-1", "gene_name": "Fcn1", "organism": "Mouse", "refseq_name": "ficolin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032021", "type": "external" } ], "gene_names_uniprotkb": "Fcn1; Fcna", "gene_names_refseq": "Fcn1; Fcna", "protein_names_uniprotkb": "Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin", "protein_names_refseq": "M-ficolin; collagen/fibrinogen domain-containing protein 1; ficolin-1 isoform 1 precursor; ficolin-1; ficolin-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:14133); (R-MMU-2855086); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15950722;16328467;17669269;30818229;32272397;37356123;38442803;9535745", "class_list": "glycogene", "function": "Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8., [UniProtKB, UniProtKB]; FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway., [RefSeq, PubMed]; Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway., [RefSeq, PubMed]; Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway., [RefSeq, PubMed]; Ficolin-A/2 Aggravates Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D-Induced Pyroptosis., [RefSeq, PubMed]; Lipopolysaccharide-induced inflammation can induce a significant ficolin response., [RefSeq, PubMed]; The expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032757 positive regulation of interleukin-8 production;GO:0001867 complement activation, lectin pathway;GO:0002752 cell surface pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70165-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70497-1", "uniprot_id": [ { "id": "FCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70497", "type": "external" } ], "mass": 33984.0, "length": 314, "protein_name": "Ficolin-2", "gene_name": "Fcn2; Fcnb", "organism": "Mouse", "refseq_name": "ficolin-2 precursor", "refseq_ac": [ { "id": "NP_034320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034320", "type": "external" } ], "gene_names_uniprotkb": "Fcn2; Fcnb; Fcnb", "gene_names_refseq": "Fcn2; Fcnb", "protein_names_uniprotkb": "Ficolin-2; Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta; L-ficolin", "protein_names_refseq": "L-ficolin; collagen/fibrinogen domain-containing protein 2; ficolin-2 precursor; ficolin-2; ficolin-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:14134); (R-MMU-2855086); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15950722;16328467;20485683;21750661;24040095;27467404;28739878;30818229;9851834", "class_list": "glycogene", "function": "Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens., [UniProtKB, UniProtKB]; Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen. The cells that express ficolin B mRNA were identified as belonging to the myeloid cell lineage., [RefSeq, PubMed]; Ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine. Ficolin B specifically recognized sialic acid residues. Ficolin B plays a distinct role through its unique carbohydrate-binding specificity., [RefSeq, PubMed]; Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. Publication Status: Online-Only, [RefSeq, PubMed]; Lipopolysaccharide-induced inflammation can induce a significant ficolin response., [RefSeq, PubMed]; This study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo, [RefSeq, PubMed]; This study shows that FCN B plays an important role in the development of collagen Ab-induced arthritis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNL6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032757 positive regulation of interleukin-8 production;GO:0034394 protein localization to cell surface;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70497-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16294-1", "uniprot_id": [ { "id": "FA9_MOUSE", "url": "https://www.uniprot.org/uniprot/P16294", "type": "external" } ], "mass": 52978.0, "length": 471, "protein_name": "Coagulation factor IX", "gene_name": "F9", "organism": "Mouse", "refseq_name": "coagulation factor IX isoform 2 precursor", "refseq_ac": [ { "id": "NP_001292726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292726", "type": "external" } ], "gene_names_uniprotkb": "F9; Cf9", "gene_names_refseq": "Cf-9; Cf9; F9", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; Christmas factor", "protein_names_refseq": "christmas factor; coagulation factor IX isoform 2 precursor", "tax_id": 10090, "disease": "X-linked warfarin sensitivity (Disease Ontology:DOID:0080839); X-linked thrombophilia due to factor IX defect (Disease Ontology:DOID:0111899); hemophilia B (Disease Ontology:DOID:12259); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14071); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;2303254;2323576;36137043", "class_list": "", "function": "Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB]; Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure., [RefSeq, PubMed]; This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 2, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UES1", "ec_number_list": [ { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "3.4.21.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.27", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16294-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17257-1", "uniprot_id": [ { "id": "F167B_MOUSE", "url": "https://www.uniprot.org/uniprot/P17257", "type": "external" } ], "mass": 18529.0, "length": 162, "protein_name": "Protein FAM167B", "gene_name": "Fam167b", "organism": "Mouse", "refseq_name": "protein FAM167B", "refseq_ac": [ { "id": "NP_877584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877584", "type": "external" } ], "gene_names_uniprotkb": "Fam167b; Sec", "gene_names_refseq": "Fam167b; SEC", "protein_names_uniprotkb": "Protein FAM167B; Protein SEC", "protein_names_refseq": "protein FAM167B", "tax_id": 10090, "disease": "", "pathway": " (mmu:230766)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2349114", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNY6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17257-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20693-1", "uniprot_id": [ { "id": "FCER2_MOUSE", "url": "https://www.uniprot.org/uniprot/P20693", "type": "external" } ], "mass": 37648.0, "length": 331, "protein_name": "Low affinity immunoglobulin epsilon Fc receptor", "gene_name": "Fcer2a; Fcer2", "organism": "Mouse", "refseq_name": "low affinity immunoglobulin epsilon Fc receptor isoform B", "refseq_ac": [ { "id": "NP_001240666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240666", "type": "external" } ], "gene_names_uniprotkb": "Fcer2a; Fcer2; Fcer2a", "gene_names_refseq": "CD23; Fce2; Fcer2a; Fcer2; Ly-42", "protein_names_uniprotkb": "Low affinity immunoglobulin epsilon Fc receptor; Fc-epsilon-RII; Lymphocyte IgE receptor", "protein_names_refseq": "FC epsilon RII; fc-epsilon-RII; low affinity immunoglobulin epsilon Fc receptor isoform B; low affinity immunoglobulin epsilon Fc receptor; low-affinity IgE receptor; lymphocyte IgE receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14128)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19224205;20173027;2137845;21750661;2529542;30084848;31437490;32152506;34428180;8086828;8142907", "class_list": "glycogene", "function": "IgE-ICs are noninflammatory through reduced engagement by FcepsilonRI but increased targeting of the CD23 pathway., [RefSeq, PubMed]; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61556;Q61557", "ec_number_list": [], "go_molecular_function": "GO:0019863 IgE binding;GO:0002020 protease binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042742 defense response to bacterium;GO:0042116 macrophage activation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20693-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28322-1", "uniprot_id": [ { "id": "ETV4_MOUSE", "url": "https://www.uniprot.org/uniprot/P28322", "type": "external" } ], "mass": 54008.0, "length": 485, "protein_name": "ETS translocation variant 4", "gene_name": "Etv4", "organism": "Mouse", "refseq_name": "ETS translocation variant 4 isoform 2", "refseq_ac": [ { "id": "NP_032841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032841", "type": "external" } ], "gene_names_uniprotkb": "Etv4; Pea-3; Pea3", "gene_names_refseq": "Etv4; Pea-3; Pea3", "protein_names_uniprotkb": "ETS translocation variant 4; Polyomavirus enhancer activator 3; Protein PEA3", "protein_names_refseq": "ETS translocation variant 4 isoform 2; ETS variant protein 4; POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4); ets variant gene 4 (E1A enhancer binding protein, E1AF)", "tax_id": 10090, "disease": "bipolar disorder (Disease Ontology:DOID:3312); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18612); (R-MMU-5687128)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12372283;1547944;21750661", "class_list": "", "function": "Transcriptional activator (PubMed:1547944). Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborization of specific motor neuron axons within their target muscles (PubMed:12372283). Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons (PubMed:12372283). May play a role in keratinocyte differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMZ6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28322-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45878-1", "uniprot_id": [ { "id": "FKBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P45878", "type": "external" } ], "mass": 15344.0, "length": 140, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP2", "gene_name": "Fkbp2", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP2 precursor", "refseq_ac": [ { "id": "NP_001159840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159840", "type": "external" } ], "gene_names_uniprotkb": "Fkbp2; Fkbp13; Gm51400", "gene_names_refseq": "Fkbp2; mFKBP13; mFKBP2", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP2; 13 kDa FK506-binding protein; 13 kDa FKBP; 5.2.1.8; FK506-binding protein 2; FKBP-13; FKBP-2; Immunophilin FKBP13; PPIase FKBP2; Rotamase", "protein_names_refseq": "13 kDa FK506-binding protein; 13 kDa FKBP; PPIase FKBP2; immunophilin FKBP13; peptidyl-prolyl cis-trans isomerase FKBP2 precursor; peptidyl-prolyl cis-trans isomerase FKBP2; rotamase", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:14227)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34428180;40997131;7505249;9531554", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P45878-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48755-1", "uniprot_id": [ { "id": "FOSL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48755", "type": "external" } ], "mass": 29800.0, "length": 273, "protein_name": "Fos-related antigen 1", "gene_name": "Fosl1", "organism": "Mouse", "refseq_name": "fos-related antigen 1", "refseq_ac": [ { "id": "NP_034365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034365", "type": "external" } ], "gene_names_uniprotkb": "Fosl1; Fra1", "gene_names_refseq": "Fosl1; Fra1; fra-1", "protein_names_uniprotkb": "Fos-related antigen 1; FRA-1", "protein_names_refseq": "fos-related antigen 1", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); stomach cancer (Disease Ontology:DOID:10534); colon adenocarcinoma (Disease Ontology:DOID:234); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); renal carcinoma (Disease Ontology:DOID:4451); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:14283)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;28135057;29272704;8892610;9294610", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35285", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042734 presynaptic membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007296 vitellogenesis;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48755-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59113-1", "uniprot_id": [ { "id": "FERM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59113", "type": "external" } ], "mass": 76941.0, "length": 677, "protein_name": "Fermitin family homolog 1", "gene_name": "Fermt1", "organism": "Mouse", "refseq_name": "fermitin family homolog 1", "refseq_ac": [ { "id": "NP_932146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932146", "type": "external" } ], "gene_names_uniprotkb": "Fermt1; Kind1; Urp1", "gene_names_refseq": "5830467P10Rik; Fermt1; Kindlin-1", "protein_names_uniprotkb": "Fermitin family homolog 1; Kindlin-1; Unc-112-related protein 1", "protein_names_refseq": "fermitin family homolog 1; unc-112-related protein 1", "tax_id": 10090, "disease": "Kindler syndrome (Disease Ontology:DOID:0060472); telangiectasis (Disease Ontology:DOID:1272); vesiculobullous skin disease (Disease Ontology:DOID:2731)", "pathway": " (mmu:241639)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16876785;19057668;19240021;19804783;26993041;30084848;31429758;36883731", "class_list": "", "function": "Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity)., [UniProtKB]; Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects, [RefSeq, PubMed]; Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis., [RefSeq, PubMed]; Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models. Publication Status: Online-Only, [RefSeq, PubMed]; The genomic organization, gene expression and subcellular localization of murine Kindlins-1 to -3, is described., [RefSeq, PubMed]; The sharpin may complex with both kindlin-1 and the integrin beta1 CT to restrict the talin head domain binding, thus inhibiting beta1-integrin activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANX1;Q8BQG6", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0030054 cell junction", "go_biological_process": "GO:0051546 keratinocyte migration;GO:0051886 negative regulation of timing of anagen;GO:2000647 negative regulation of stem cell proliferation;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59113-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70266-1", "uniprot_id": [ { "id": "F261_MOUSE", "url": "https://www.uniprot.org/uniprot/P70266", "type": "external" } ], "mass": 54849.0, "length": 471, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1", "gene_name": "Pfkfb1", "organism": "Mouse", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform 2", "refseq_ac": [ { "id": "NP_032850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032850", "type": "external" } ], "gene_names_uniprotkb": "Pfkfb1", "gene_names_refseq": "PFK/FBPase 1; Pfkfb1", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFK/FBPase 1", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFK-2/FBPase-2 gene A", "tax_id": 10090, "disease": "hyperinsulinism (Disease Ontology:DOID:2018)", "pathway": " (mmu:18639); (R-MMU-9634600)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;8814283", "class_list": "", "function": "Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AFN0;Q3V180", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0032024 positive regulation of insulin secretion;GO:0006094 gluconeogenesis;GO:0045821 positive regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70266-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70351-1", "uniprot_id": [ { "id": "EZH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70351", "type": "external" } ], "mass": 85188.0, "length": 747, "protein_name": "Histone-lysine N-methyltransferase EZH1", "gene_name": "Ezh1", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase EZH1 isoform 1", "refseq_ac": [ { "id": "NP_031996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031996", "type": "external" } ], "gene_names_uniprotkb": "Ezh1; Enx2", "gene_names_refseq": "ENX-2; Ezh1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EZH1; 2.1.1.356; ENX-2; Enhancer of zeste homolog 1", "protein_names_refseq": "enhancer of zeste homolog 1; histone-lysine N-methyltransferase EZH1 isoform 1; histone-lysine N-methyltransferase EZH1", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:14055); (R-MMU-212300)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10051331;11471062;19026780;20144788;21750661;30084848;31451685;38529784;9214638;9473645", "class_list": "", "function": "Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos., [RefSeq, PubMed]; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation., [UniProtKB, PubMed]; This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A4K5;Q3TPR1;Q3U3V5;Q3UU02;Q8BR85;Q922L1;Q9R089", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0031491 nucleosome binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0046976 histone H3K27 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035098 ESC/E(Z) complex;GO:0000792 heterochromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70351-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70378-1", "uniprot_id": [ { "id": "FGF11_MOUSE", "url": "https://www.uniprot.org/uniprot/P70378", "type": "external" } ], "mass": 25178.0, "length": 225, "protein_name": "Fibroblast growth factor 11", "gene_name": "Fgf11", "organism": "Mouse", "refseq_name": "fibroblast growth factor 11 isoform 2", "refseq_ac": [ { "id": "NP_001278033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278033", "type": "external" } ], "gene_names_uniprotkb": "Fgf11; Fhf3", "gene_names_refseq": "Fgf-11; Fgf11; Fgf1d; Fhf-3; Fhf3", "protein_names_uniprotkb": "Fibroblast growth factor 11; FGF-11; FHF-3; Fibroblast growth factor homologous factor 3", "protein_names_refseq": "fibroblast growth factor 11 isoform 2; fibroblast growth factor 1d; fibroblast growth factor homologous factor 3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (mmu:14166)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "36064426;8790420", "class_list": "glycogene", "function": "Probably involved in nervous system development and function., [UniProtKB]; Silencing of hypothalamic FGF11 prevents diet-induced obesity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F291", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70378-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149F3-1", "uniprot_id": [ { "id": "ERF3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149F3", "type": "external" } ], "mass": 69147.0, "length": 632, "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B", "gene_name": "Gspt2", "organism": "Mouse", "refseq_name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3B", "refseq_ac": [ { "id": "NP_032205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032205", "type": "external" } ], "gene_names_uniprotkb": "Gspt2; Erf3b", "gene_names_refseq": "Gspt2", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; 3.6.5.-; Eukaryotic peptide chain release factor subunit 3b; G1 to S phase transition protein 2 homolog; eRF3b", "protein_names_refseq": "G1 to S phase transition protein 2 homolog; eRF3b; eukaryotic peptide chain release factor GTP-binding subunit ERF3B; eukaryotic peptide chain release factor subunit 3b", "tax_id": 10090, "disease": "", "pathway": " (mmu:14853); (R-MMU-72764); (R-MMU-975956); (R-MMU-975957)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12354098;15987998;22872234;31219806;34203471;9712840", "class_list": "", "function": "GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:12354098). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (By similarity). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88180;Q9CY91", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003747 translation release factor activity", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006415 translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q149F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TB54-1", "uniprot_id": [ { "id": "FCAMR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2TB54", "type": "external" } ], "mass": 57823.0, "length": 535, "protein_name": "High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor", "gene_name": "Fcamr", "organism": "Mouse", "refseq_name": "high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1", "refseq_ac": [ { "id": "NP_001164103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164103", "type": "external" } ], "gene_names_uniprotkb": "Fcamr", "gene_names_refseq": "Fcamr", "protein_names_uniprotkb": "High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Fc alpha/mu receptor; mFcamR", "protein_names_refseq": "Fc IgA/IgM receptor; Fca/m receptor; fc alpha/mu receptor; high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1; high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; mFcamR", "tax_id": 10090, "disease": "", "pathway": " (mmu:64435); (R-MMU-202733)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11062505;11797105;12527391;16681999;27146354;29459869;35820727", "class_list": "", "function": "Expressed in oligodendrocytes, their precursor cells, and myelin, [RefSeq, PubMed]; Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM., [UniProtKB, PubMed]; These results reveal a critical role for FcmuR in the survival and activation of marginal zone B cells and in protection against acute bacterial infection. Publication Status: Online-Only, [RefSeq, PubMed]; Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB55;Q920L8;Q9EQT7", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019862 IgA binding;GO:0001791 IgM binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2TB54-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJ29-1", "uniprot_id": [ { "id": "FBXL7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5BJ29", "type": "external" } ], "mass": 54646.0, "length": 491, "protein_name": "F-box/LRR-repeat protein 7", "gene_name": "Fbxl7", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 7", "refseq_ac": [ { "id": "NP_795933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795933", "type": "external" } ], "gene_names_uniprotkb": "Fbxl7; Kiaa0840", "gene_names_refseq": "D230018M15Rik; FBL7; Fbl6; Fbxl7", "protein_names_uniprotkb": "F-box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7", "protein_names_refseq": "F-box/LRR-repeat protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:448987); (R-MMU-8854050); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22306998;25778398;30016717", "class_list": "", "function": "FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:22306998, PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (PubMed:22306998). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398)., [UniProtKB, PubMed, PubMed]; The Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5BJ29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTI8-1", "uniprot_id": [ { "id": "ESYT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTI8", "type": "external" } ], "mass": 100068.0, "length": 891, "protein_name": "Extended synaptotagmin-3", "gene_name": "Esyt3", "organism": "Mouse", "refseq_name": "extended synaptotagmin-3", "refseq_ac": [ { "id": "NP_808443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808443", "type": "external" } ], "gene_names_uniprotkb": "Esyt3; D9Ertd280e; Fam62c; Kiaa4186", "gene_names_refseq": "D930024E11; D9Ertd280e; Esyt3; Fam62c; mKIAA4186", "protein_names_uniprotkb": "Extended synaptotagmin-3; E-Syt3", "protein_names_refseq": "E-Syt3; extended synaptotagmin-3; family with sequence similarity 62 (C2 domain containing), member C; family with sequence similarity 62, member C", "tax_id": 10090, "disease": "", "pathway": " (mmu:272636); (R-MMU-9845576)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;32747560;34428180;35820727", "class_list": "", "function": "Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders., [RefSeq, PubMed]; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF61;Q8C3B9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006869 lipid transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5DTI8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F226-1", "uniprot_id": [ { "id": "FAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5F226", "type": "external" } ], "mass": 480109.0, "length": 4351, "protein_name": "Protocadherin Fat 2", "gene_name": "Fat2", "organism": "Mouse", "refseq_name": "protocadherin Fat 2 precursor", "refseq_ac": [ { "id": "NP_001025159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025159", "type": "external" } ], "gene_names_uniprotkb": "Fat2; Fath2; Kiaa0811", "gene_names_refseq": "EMI2; Fat2; Fath2; Gm523; mKIAA0811", "protein_names_uniprotkb": "Protocadherin Fat 2; FAT tumor suppressor homolog 2", "protein_names_refseq": "protocadherin Fat 2 precursor; protocadherin Fat 2", "tax_id": 10090, "disease": "spinocerebellar ataxia 45 (Disease Ontology:DOID:0080287)", "pathway": " (mmu:245827)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;30084848;30899004;34418053;34428180;35820727", "class_list": "", "function": "Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 22, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 23, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 23, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 23, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 1, "glyco_site_count": 40, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1D4;Q69ZY7", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031589 cell-substrate adhesion;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q5F226-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SXJ3-1", "uniprot_id": [ { "id": "FANCJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SXJ3", "type": "external" } ], "mass": 131360.0, "length": 1174, "protein_name": "Fanconi anemia group J protein homolog", "gene_name": "Brip1", "organism": "Mouse", "refseq_name": "Fanconi anemia group J protein homolog", "refseq_ac": [ { "id": "NP_840094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_840094", "type": "external" } ], "gene_names_uniprotkb": "Brip1; Bach1; Fancj", "gene_names_refseq": "3110009N10Rik; 8030460J03Rik; Bach1; Brip1; FACJ; Fancj; OF", "protein_names_uniprotkb": "Fanconi anemia group J protein homolog; 5.6.2.3; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; DNA 5'-3' helicase FANCJ", "protein_names_refseq": "ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; DNA 5'-3' helicase FANCJ; Fanconi anemia group J protein homolog", "tax_id": 10090, "disease": "Fanconi anemia complementation group J (Disease Ontology:DOID:0111097); Alzheimer's disease (Disease Ontology:DOID:10652); Fanconi anemia (Disease Ontology:DOID:13636); Down syndrome (Disease Ontology:DOID:14250); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:237911); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 10, "publication_count": 7, "publication_id_list": "11595410;20122882;25428506;25605945;26490168;34428180;38377115", "class_list": "", "function": "Compares the human homolog to other members of the RecQ helicase family, [RefSeq, PubMed]; DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease. Can unwind RNA:DNA hybrids and G-quadruplex DNA., [UniProtKB, UniProtKB]; FANCJ play roles in spermatogenesis at two stages: firstly in the proliferative activity that gives rise to the full complement of testicular spermatogonia and secondly in the establishment of appropriate crossovers numbers during prophase I., [RefSeq, PubMed]; Review of the functions and disease associations of human FANCJ. Review article, [RefSeq, PubMed]; The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJQ8;Q8BKI6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005657 replication fork", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SXJ3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63880-1", "uniprot_id": [ { "id": "EST3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63880", "type": "external" } ], "mass": 63318.0, "length": 571, "protein_name": "Carboxylesterase 3A", "gene_name": "Ces3a", "organism": "Mouse", "refseq_name": "carboxylesterase 3A isoform 2 precursor", "refseq_ac": [ { "id": "NP_001158153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158153", "type": "external" } ], "gene_names_uniprotkb": "Ces3a; Es31", "gene_names_refseq": "Ces31; Ces3a; Ces3; Es31", "protein_names_uniprotkb": "Carboxylesterase 3A; 3.1.1.1; ES-male; Esterase-31; Liver carboxylesterase 31", "protein_names_refseq": "Es-male carboxylesterase; carboxylesterase 3A isoform 2 precursor; esterase 31; liver carboxylesterase 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:382053); (R-MMU-211945); (R-MMU-8964038)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;23744992;24362705;30807212;31616917;34428180;36064721;37453647;7916639", "class_list": "glycogene", "function": "Activation of Ces3 contributes in the browning of white adipocytes, and maintains a balance in lipid metabolism, which could be a potential strategy in fighting against obesity, [RefSeq, PubMed]; Hepatic Ces3 modulates the hydrolysis of lipoprotein-delivered cholesterol esters and thereby regulates free cholesterol and bile acid secretion into the feces., [RefSeq, PubMed]; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs., [UniProtKB]; This carboxylesterase proetin is linked to obesity and diabetes in mice, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEJ0;Q3UU08;Q6P8Z0;Q6PG74;Q810S9", "ec_number_list": [ { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.67", "type": "external" } ], "go_molecular_function": "GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63880-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68SN8-1", "uniprot_id": [ { "id": "FCRL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68SN8", "type": "external" } ], "mass": 66779.0, "length": 596, "protein_name": "Fc receptor-like protein 5", "gene_name": "Fcrl5", "organism": "Mouse", "refseq_name": "Fc receptor-like protein 5 isoform b precursor", "refseq_ac": [ { "id": "NP_001106709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106709", "type": "external" } ], "gene_names_uniprotkb": "Fcrl5; Fcrh3", "gene_names_refseq": "Fcrh3; Fcrl5; mBXMH2", "protein_names_uniprotkb": "Fc receptor-like protein 5; BXMAS1-like protein 2; Fc receptor homolog 3; FcR-like protein 5; FcRH3; FcRL5; mBXMH2; moFcRH3", "protein_names_refseq": "BXMAS1-like protein 2; Fc receptor-like protein 3; Fc receptor-like protein 5 isoform b precursor; Fc receptor-like protein 5; fc receptor homolog 3; fcR-like protein 5; moFcRH3", "tax_id": 10090, "disease": "", "pathway": " (mmu:329693)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15302849;17082595;21750661;23509253;26495903;36070373;37841260", "class_list": "", "function": "A novel immunoregulatory marker of splenic marginal zone and B1 type B lineage cells., [RefSeq, PubMed]; FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling., [RefSeq, PubMed]; Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (By similarity). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (PubMed:36070373)., [UniProtKB, PubMed, UniProtKB]; Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease. Erratum:[Front Immunol. 2024 Jan 08;14:1356364. doi: 10.3389/fimmu.2023.1356364. PMID: 38259460] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QLI5;Q80WN2;Q8BJA5", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0015026 coreceptor activity;GO:0019900 kinase binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007338 single fertilization;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68SN8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z69-1", "uniprot_id": [ { "id": "ESCO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z69", "type": "external" } ], "mass": 94999.0, "length": 843, "protein_name": "N-acetyltransferase ESCO1", "gene_name": "Esco1", "organism": "Mouse", "refseq_name": "N-acetyltransferase ESCO1", "refseq_ac": [ { "id": "NP_001074691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074691", "type": "external" } ], "gene_names_uniprotkb": "Esco1; Kiaa1911", "gene_names_refseq": "A930014I12Rik; Esco1", "protein_names_uniprotkb": "N-acetyltransferase ESCO1; 2.3.1.-; ECO1 homolog 1; Establishment of cohesion 1 homolog 1", "protein_names_refseq": "ECO1 homolog 1; N-acetyltransferase ESCO1; establishment of cohesion 1 homolog 1; establisment of cohesion 1 homolog 1", "tax_id": 10090, "disease": "Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (mmu:77805); (R-MMU-2468052)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;29361031;32555289", "class_list": "", "function": "Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3., [UniProtKB, UniProtKB]; Alternative catalytic residues in the active site of Esco acetyltransferases. Publication Status: Online-Only, [RefSeq, PubMed]; Esco1 is required for alpha-tubulin acetylation and microtubule stability, which thereby ensures normal spindle assembly and proper chromosome alignment to orchestrate the mouse oocyte meiotic progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKQ9;Q8BQI2;Q8BR47;Q922F5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0016407 acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006275 regulation of DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0018394 peptidyl-lysine acetylation;GO:0034421 post-translational protein acetylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q69Z69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RI63-1", "uniprot_id": [ { "id": "F120B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6RI63", "type": "external" } ], "mass": 89313.0, "length": 786, "protein_name": "Constitutive coactivator of peroxisome proliferator-activated receptor gamma", "gene_name": "Fam120b", "organism": "Mouse", "refseq_name": "constitutive coactivator of peroxisome proliferator-activated receptor gamma", "refseq_ac": [ { "id": "NP_077165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077165", "type": "external" } ], "gene_names_uniprotkb": "Fam120b; Ccpg; Kiaa1838", "gene_names_refseq": "4932442K08Rik; CCPG; Fam120b; Pgcc1; mKIAA1838", "protein_names_uniprotkb": "Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Constitutive coactivator of PPAR-gamma; Constitutive coactivator of PPARG; Protein FAM120B", "protein_names_refseq": "constitutive coactivator of PPAR-gamma; constitutive coactivator of PPARG; constitutive coactivator of peroxisome proliferator-activated receptor gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:67544)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17595322;21400663;29968717;34339838", "class_list": "", "function": "CCPG is a bona fide coactivator and promotes adipogenesis in a PPARgamma-dependent manner., [RefSeq, PubMed]; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation., [UniProtKB, PubMed]; San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia., [RefSeq, PubMed]; Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; Sulfonylthiadiazoles with an unusual binding mode were shown as partial dual peroxisome proliferator-activated receptor (PPAR) gamma/delta agonists with high potency and in vivo efficacy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTU5;Q8BK59;Q8BVH5;Q8BWQ3;Q8C158;Q99LL4;Q9DAC3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045444 fat cell differentiation;GO:0035357 peroxisome proliferator activated receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6RI63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZA7-1", "uniprot_id": [ { "id": "FMR1N_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZA7", "type": "external" } ], "mass": 27018.0, "length": 238, "protein_name": "Fmr1 neighbor protein", "gene_name": "Fmr1nb", "organism": "Mouse", "refseq_name": "fmr1 neighbor protein isoform 2", "refseq_ac": [ { "id": "NP_001160091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160091", "type": "external" } ], "gene_names_uniprotkb": "Fmr1nb", "gene_names_refseq": "3830422N12Rik; Fmr1nb; NY-SAR-35; NYSAR35", "protein_names_uniprotkb": "Fmr1 neighbor protein; Protein mNY-SAR-35", "protein_names_refseq": "fmr1 neighbor protein isoform 2; fmr1 neighbor protein; protein mNY-SAR-35", "tax_id": 10090, "disease": "", "pathway": " (mmu:207854)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12601173", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQU9;Q4KL61;Q8BPD4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH61-1", "uniprot_id": [ { "id": "F13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH61", "type": "external" } ], "mass": 83207.0, "length": 732, "protein_name": "Coagulation factor XIII A chain", "gene_name": "F13a1", "organism": "Mouse", "refseq_name": "coagulation factor XIII A chain", "refseq_ac": [ { "id": "NP_001159863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159863", "type": "external" } ], "gene_names_uniprotkb": "F13a1; F13a", "gene_names_refseq": "1200014I03Rik; F13a1; F13a", "protein_names_uniprotkb": "Coagulation factor XIII A chain; 2.3.2.13; Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain", "protein_names_refseq": "coagulation factor XIII A chain; coagulation factor XIII, alpha subunit; coagulation factor XIIIa; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); gastric ulcer (Disease Ontology:DOID:10808); disseminated intravascular coagulation (Disease Ontology:DOID:11247); factor XIII deficiency (Disease Ontology:DOID:2211); arteriosclerosis (Disease Ontology:DOID:2349); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); priapism (Disease Ontology:DOID:9286); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (mmu:74145); (R-MMU-114608); (R-MMU-9769733)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12529747;12933578;15131115;26740625;34428180;36006736;36210013;37507081;37883802", "class_list": "", "function": "Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin., [UniProtKB, UniProtKB]; Impaired clot stabilization in FXIII-A mutant mice, [RefSeq, PubMed]; Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections. Publication Status: Online-Only, [RefSeq, PubMed]; Maternal FXIII plays a critical role in uterine hemostasis and maintenance of the placenta during gestation., [RefSeq, PubMed]; Platelet FXIII and calpain have roles in regulating integrin alpha(IIb)beta3 adhesive function, [RefSeq, PubMed]; Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration., [RefSeq, PubMed]; This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNF9;Q8BIP2", "ec_number_list": [ { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007596 blood coagulation;GO:0018149 peptide cross-linking;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BH61-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJL1-1", "uniprot_id": [ { "id": "FBX30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJL1", "type": "external" } ], "mass": 82687.0, "length": 746, "protein_name": "F-box only protein 30", "gene_name": "Fbxo30", "organism": "Mouse", "refseq_name": "F-box only protein 30", "refseq_ac": [ { "id": "NP_001161769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161769", "type": "external" } ], "gene_names_uniprotkb": "Fbxo30", "gene_names_refseq": "1700026A16Rik; Fbxo30; MUSA1", "protein_names_uniprotkb": "F-box only protein 30; MUSA1; Muscle ubiquitin ligase of SCF complex in atrophy-1", "protein_names_refseq": "F-box only protein 30; muscle ubiquitin ligase of SCF complex in atrophy-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71865); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24076600;27117404;28528544;30059200;30980108", "class_list": "", "function": "Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis., [RefSeq, PubMed]; MUSA1 inhibition significantly protected denervated muscles from atrophy and the drastic atrophy seen in Smad4-deficient muscles was blunted [MUSA1], [RefSeq, PubMed]; SLBP overexpression caused by Fbxo30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation. The finding uncovers an unidentified pathway-controlling chromosome segregation and cell progress., [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXU4;Q8CI21;Q9D9X5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0030261 chromosome condensation;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BJL1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJN4-1", "uniprot_id": [ { "id": "FNDC9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJN4", "type": "external" } ], "mass": 25656.0, "length": 226, "protein_name": "Fibronectin type III domain-containing protein 9", "gene_name": "Fndc9", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 9", "refseq_ac": [ { "id": "NP_796049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796049", "type": "external" } ], "gene_names_uniprotkb": "Fndc9", "gene_names_refseq": "C030019I05Rik; Fndc9", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 9", "protein_names_refseq": "fibronectin type III domain-containing protein 9; fibronectin type-III domain-containing protein C5orf40 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:320116)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BJN4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLQ0-1", "uniprot_id": [ { "id": "F124B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLQ0", "type": "external" } ], "mass": 52079.0, "length": 456, "protein_name": "Protein FAM124B", "gene_name": "Fam124b", "organism": "Mouse", "refseq_name": "protein FAM124B", "refseq_ac": [ { "id": "NP_775601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775601", "type": "external" } ], "gene_names_uniprotkb": "Fam124b", "gene_names_refseq": "A830043J08Rik; Fam124b", "protein_names_uniprotkb": "Protein FAM124B", "protein_names_refseq": "protein FAM124B", "tax_id": 10090, "disease": "", "pathway": " (mmu:241128); (R-MMU-9943962)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23285124", "class_list": "", "function": "Fam124B is a novel protein possibly involved in the pathogenesis of CHARGE syndrome and neurodevelopmental disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BLQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQB4-1", "uniprot_id": [ { "id": "FJX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQB4", "type": "external" } ], "mass": 50396.0, "length": 450, "protein_name": "Four-jointed box protein 1", "gene_name": "Fjx1", "organism": "Mouse", "refseq_name": "four-jointed box protein 1 precursor", "refseq_ac": [ { "id": "NP_034348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034348", "type": "external" } ], "gene_names_uniprotkb": "Fjx1", "gene_names_refseq": "Fjx1", "protein_names_uniprotkb": "Four-jointed box protein 1; Four-jointed protein homolog; Four-jointed protein x1", "protein_names_refseq": "four-jointed box protein 1 precursor; four-jointed box protein 1; four-jointed protein homolog; four-jointed protein x1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14221)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10072791;16059920;16145673;18028897;31038742;37439170", "class_list": "", "function": "Acts as an inhibitor of dendrite extension and branching., [UniProtKB, PubMed]; Data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates, [RefSeq, PubMed]; Fjx1 disruption protects the cystic kidneys against kidney failure by reducing inflammation and fibrosis., [RefSeq, PubMed]; [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1M1", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BQB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTW3-1", "uniprot_id": [ { "id": "EXOS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTW3", "type": "external" } ], "mass": 28370.0, "length": 273, "protein_name": "Exosome complex component MTR3", "gene_name": "Exosc6", "organism": "Mouse", "refseq_name": "exosome complex component MTR3", "refseq_ac": [ { "id": "NP_082550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082550", "type": "external" } ], "gene_names_uniprotkb": "Exosc6; Mtr3", "gene_names_refseq": "2610510N21Rik; C76919; Exosc6; Mtr3", "protein_names_uniprotkb": "Exosome complex component MTR3; Exosome component 6; mRNA transport regulator 3 homolog", "protein_names_refseq": "Mtr3 (mRNA transport regulator 3)-homolog; exosome complex component MTR3; exosome complex exonuclease MTR3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72544); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "21255825", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSR7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0045190 isotype switching;GO:0006364 rRNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BTW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWY3-1", "uniprot_id": [ { "id": "ERF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWY3", "type": "external" } ], "mass": 49031.0, "length": 437, "protein_name": "Eukaryotic peptide chain release factor subunit 1", "gene_name": "Etf1", "organism": "Mouse", "refseq_name": "eukaryotic peptide chain release factor subunit 1", "refseq_ac": [ { "id": "NP_659115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659115", "type": "external" } ], "gene_names_uniprotkb": "Etf1", "gene_names_refseq": "D6Ertd109e; ERF1; ERF; Etf1; SUP45L1; TB3-1", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; eRF1", "protein_names_refseq": "eukaryotic peptide chain release factor subunit 1; eukaryotic release factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225363); (R-MMU-72764); (R-MMU-9629569); (R-MMU-975956); (R-MMU-975957)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "14636559;20485683;20606008;24486019;26495903;26944478;34428180;35984892;37453647", "class_list": "", "function": "Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site, followed by hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes., [UniProtKB, UniProtKB]; Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms, [RefSeq, PubMed]; Reverse Transcriptase enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPZ6;Q91VH9", "ec_number_list": [], "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:1990825 sequence-specific mRNA binding;GO:0008079 translation termination factor activity;GO:0003747 translation release factor activity;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0032790 ribosome disassembly;GO:0002184 cytoplasmic translational termination;GO:0006415 translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BWY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEF1-1", "uniprot_id": [ { "id": "FEM1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEF1", "type": "external" } ], "mass": 68578.0, "length": 617, "protein_name": "Protein fem-1 homolog C", "gene_name": "Fem1c", "organism": "Mouse", "refseq_name": "protein fem-1 homolog C", "refseq_ac": [ { "id": "NP_775599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775599", "type": "external" } ], "gene_names_uniprotkb": "Fem1c; Kiaa1785", "gene_names_refseq": "2610312A07Rik; 3632443A22Rik; Fem1c", "protein_names_uniprotkb": "Protein fem-1 homolog C; FEM1-gamma; FEM1c", "protein_names_refseq": "FEM1-gamma; protein fem-1 homolog C", "tax_id": 10090, "disease": "", "pathway": " (mmu:240263); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14527725;15082774;25428506;30084848;30779550;34428180;35820727", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (By similarity). Promotes ubiquitination and degradation of SLBP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGV8;Q8C7S4", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CEF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CF02-1", "uniprot_id": [ { "id": "FM25C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CF02", "type": "external" } ], "mass": 9235.0, "length": 89, "protein_name": "Protein FAM25A", "gene_name": "Fam25a", "organism": "Mouse", "refseq_name": "protein FAM25A", "refseq_ac": [ { "id": "NP_899101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899101", "type": "external" } ], "gene_names_uniprotkb": "Fam25a; Fam25c", "gene_names_refseq": "2200001I15Rik; Fam25a; Fam25c; Fam25", "protein_names_uniprotkb": "Protein FAM25A; Protein FAM25C", "protein_names_refseq": "family with sequence similarity 25, member C; protein FAM25A; protein FAM25C; protein FAM25", "tax_id": 10090, "disease": "", "pathway": " (mmu:69134)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CF02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHT6-1", "uniprot_id": [ { "id": "F169B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHT6", "type": "external" } ], "mass": 38125.0, "length": 337, "protein_name": "Protein FAM169B", "gene_name": "Fam169b", "organism": "Mouse", "refseq_name": "protein FAM169B isoform 2", "refseq_ac": [ { "id": "NP_001013833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013833", "type": "external" } ], "gene_names_uniprotkb": "Fam169b", "gene_names_refseq": "EG434197; Fam169b", "protein_names_uniprotkb": "Protein FAM169B", "protein_names_refseq": "protein FAM169B isoform 2; protein FAM169B", "tax_id": 10090, "disease": "", "pathway": " (mmu:434197)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CHT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Z2-2", "uniprot_id": [ { "id": "FNDC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4Z2", "type": "external" } ], "mass": 26468.0, "length": 240, "protein_name": "Fibronectin type III domain-containing protein 5", "gene_name": "Fndc5", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 5 preproprotein", "refseq_ac": [ { "id": "NP_081678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081678", "type": "external" } ], "gene_names_uniprotkb": "Fndc5; Frcp2; Pep", "gene_names_refseq": "1500001L03Rik; Fndc5; PeP; Pxp", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; PeP; Peroxisomal protein", "protein_names_refseq": "fibronectin type III domain-containing protein 5 preproprotein; fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2; peroxisomal protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:384061)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12112469;12384288;22237023;23219938;38661340;38802337;39187335", "class_list": "", "function": "Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner. Publication Status: Online-Only, [RefSeq, PubMed]; FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control. Erratum:[Cell Death Dis. 2024 Jul 24;15(7):527. doi: 10.1038/s41419-024-06901-5. PMID: 39048543] Publication Status: Online-Only, [RefSeq, PubMed]; Fndc5 expression is required for the appropriate neural differentiation of mESCs. These data confirm the importance of Fndc5 in the generation and development of the nervous system., [RefSeq, PubMed]; Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA., [UniProtKB, PubMed]; The Effect of Hypoxia on Irisin Expression in HL-1 Cardiomyocytes., [RefSeq, PubMed]; This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9890, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AA74KUW2;Q9DB97", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0014850 response to muscle activity;GO:0090336 positive regulation of brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K4Z2-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WF7-1", "uniprot_id": [ { "id": "FIG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WF7", "type": "external" } ], "mass": 103447.0, "length": 907, "protein_name": "Polyphosphoinositide phosphatase", "gene_name": "Fig4", "organism": "Mouse", "refseq_name": "polyphosphoinositide phosphatase", "refseq_ac": [ { "id": "NP_598760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598760", "type": "external" } ], "gene_names_uniprotkb": "Fig4; Kiaa0274; Sac3", "gene_names_refseq": "A530089I17Rik; Fig4; Sac3", "protein_names_uniprotkb": "Polyphosphoinositide phosphatase; 3.1.3.-; 3.1.3.16; 3.1.3.36; 3.1.3.86; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3; Serine-protein phosphatase FIG4", "protein_names_refseq": "FIG4 homolog; SAC domain-containing protein 3; Sac domain-containing inositol phosphatase 3; phosphatidylinositol 3,5-bisphosphate 5-phosphatase; polyphosphoinositide phosphatase; serine-protein phosphatase FIG4", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 11 (Disease Ontology:DOID:0060202); Yunis-Varon syndrome (Disease Ontology:DOID:0060589); bilateral parasagittal parieto-occipital polymicrogyria (Disease Ontology:DOID:0080923); Charcot-Marie-Tooth disease type 4J (Disease Ontology:DOID:0110184); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:103199); (R-MMU-1660514); (R-MMU-1660516); (R-MMU-1660517)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "17572665;19037259;19578118;20630877;25428506;29688489;30084848;30779550;31219806;33878035;34428180;36691351;37363915", "class_list": "", "function": "A novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J., [RefSeq, PubMed]; AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model., [RefSeq, PubMed]; Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c., [RefSeq, PubMed]; Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro., [UniProtKB, PubMed, PubMed, UniProtKB]; In the adult PNS Fig4 is required to protect myelinated axons from Wallerian degeneration. In the adult CNS, Fig4 is dispensable for fiber stability and nerve conduction, but is required for the timely repair of damaged white matter. The greater vulnerability of the PNS to Fig4 deficiency in the mouse is consistent with clinical observations in patients with Charcot-Marie-Tooth disease., [RefSeq, PubMed]; Sac3 as an insulin-sensitive phosphatase whose down-regulation increases insulin responsiveness, thus implicating Sac3 as a novel drug target in insulin resistance., [RefSeq, PubMed]; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes., [UniProtKB, PubMed, PubMed]; The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants. Publication Status: Online-Only, [RefSeq, PubMed]; The pale tremor mutant provides the first evidence regarding the functional role of mammalian Fig4, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A092", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0034593 phosphatidylinositol bisphosphate phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0055037 recycling endosome;GO:0010008 endosome membrane;GO:0070772 PAS complex", "go_biological_process": "GO:0007626 locomotory behavior;GO:0010976 positive regulation of neuron projection development;GO:0048666 neuron development;GO:0043473 pigmentation;GO:0007033 vacuole organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91WF7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MX2-1", "uniprot_id": [ { "id": "FH17E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MX2", "type": "external" } ], "mass": 20491.0, "length": 176, "protein_name": "Ferritin heavy polypeptide-like 17E", "gene_name": "Fthl17e", "organism": "Mouse", "refseq_name": "ferritin heavy polypeptide-like 17E", "refseq_ac": [ { "id": "NP_112551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112551", "type": "external" } ], "gene_names_uniprotkb": "Fthl17e; Fthl17", "gene_names_refseq": "Fthl17e; Fthl17", "protein_names_uniprotkb": "Ferritin heavy polypeptide-like 17E", "protein_names_refseq": "ferritin heavy polypeptide-like 17E", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:83457)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11279525;25749565", "class_list": "", "function": "FTHL17 encodes a ferritin-like protein without ferroxidase activity. Its restricted embryonic expression and partial nuclear localization suggest that this novel ferritin type may have functions other than iron storage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "L7MU38", "ec_number_list": [], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99MX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPW2-1", "uniprot_id": [ { "id": "FDX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPW2", "type": "external" } ], "mass": 18766.0, "length": 174, "protein_name": "Ferredoxin-2, mitochondrial", "gene_name": "Fdx2", "organism": "Mouse", "refseq_name": "ferredoxin-2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001034913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034913", "type": "external" } ], "gene_names_uniprotkb": "Fdx2; Fdx1l", "gene_names_refseq": "B230118G17Rik; Fdx1l; Fdx2", "protein_names_uniprotkb": "Ferredoxin-2, mitochondrial; Adrenodoxin-like protein; Ferredoxin-1-like protein", "protein_names_refseq": "adrenodoxin-like protein, mitochondrial; ferredoxin 1-like; ferredoxin-1-like protein; ferredoxin-2, mitochondrial precursor; ferredoxin-2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68165); (R-MMU-1362409); (R-MMU-196108); (R-MMU-211976); (R-MMU-2395516)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8M0;Q9CV00", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1904322 cellular response to forskolin;GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CPW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2H8-1", "uniprot_id": [ { "id": "FNDC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2H8", "type": "external" } ], "mass": 35619.0, "length": 321, "protein_name": "Fibronectin type III domain-containing protein 8", "gene_name": "Fndc8", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 8", "refseq_ac": [ { "id": "NP_084500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084500", "type": "external" } ], "gene_names_uniprotkb": "Fndc8", "gene_names_refseq": "4930466G16Rik; Fndc8", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 8", "protein_names_refseq": "fibronectin type III domain-containing protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:78919)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUG1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D2H8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAA6-1", "uniprot_id": [ { "id": "EXOS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAA6", "type": "external" } ], "mass": 21424.0, "length": 195, "protein_name": "Exosome complex component CSL4", "gene_name": "Exosc1", "organism": "Mouse", "refseq_name": "exosome complex component CSL4 isoform 2", "refseq_ac": [ { "id": "NP_001158033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158033", "type": "external" } ], "gene_names_uniprotkb": "Exosc1; Csl4", "gene_names_refseq": "2610035C18Rik; 2610104C07Rik; 2610312F07Rik; Exosc1", "protein_names_uniprotkb": "Exosome complex component CSL4; Exosome component 1", "protein_names_refseq": "3'-5' exoribonuclease CSL4 homolog; exosome complex component CSL4 isoform 2; exosome complex component CSL4", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 1F (Disease Ontology:DOID:0112331); microcephaly (Disease Ontology:DOID:10907); scleral disease (Disease Ontology:DOID:11343); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:66583); (R-MMU-429958); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604); (R-MMU-6791226); (R-MMU-9930044)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "25605945;34159897;34428180", "class_list": "", "function": "Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCB9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAA6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAK4-1", "uniprot_id": [ { "id": "FBP12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAK4", "type": "external" } ], "mass": 14758.0, "length": 132, "protein_name": "Fatty acid-binding protein 12", "gene_name": "Fabp12", "organism": "Mouse", "refseq_name": "fatty acid-binding protein 12", "refseq_ac": [ { "id": "NP_083586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083586", "type": "external" } ], "gene_names_uniprotkb": "Fabp12", "gene_names_refseq": "1700008G05Rik; Fabp12", "protein_names_uniprotkb": "Fatty acid-binding protein 12", "protein_names_refseq": "fatty acid-binding protein 12; intracellular fatty acid-binding protein FABP12; probable fatty acid-binding protein ENSP00000353650 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75497); (R-MMU-163560)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18786628", "class_list": "", "function": "FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family., [RefSeq, PubMed]; May play a role in lipid transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7SUM9", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCL2-1", "uniprot_id": [ { "id": "CIA2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCL2", "type": "external" } ], "mass": 18418.0, "length": 160, "protein_name": "Cytosolic iron-sulfur assembly component 2A", "gene_name": "Ciao2a", "organism": "Mouse", "refseq_name": "cytosolic iron-sulfur assembly component 2A isoform 1", "refseq_ac": [ { "id": "NP_080911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080911", "type": "external" } ], "gene_names_uniprotkb": "Ciao2a; Fam96a", "gene_names_refseq": "5730536A07Rik; Ciao2a; Fam96a", "protein_names_uniprotkb": "Cytosolic iron-sulfur assembly component 2A; MIP18 family protein FAM96A", "protein_names_refseq": "MIP18 family protein FAM96A; cytosolic iron-sulfur assembly component 2A isoform 1; family with sequence similarity 96, member A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68250)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "22683786;23891004;25716227;29320706;33232517;34428180;36150559;38713713", "class_list": "", "function": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227)., [UniProtKB, PubMed, PubMed]; FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice., [RefSeq, PubMed]; FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis., [RefSeq, PubMed]; Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD02;Q9D171", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0007059 chromosome segregation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DCL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQR6-1", "uniprot_id": [ { "id": "FANCG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQR6", "type": "external" } ], "mass": 68506.0, "length": 623, "protein_name": "Fanconi anemia group G protein homolog", "gene_name": "Fancg", "organism": "Mouse", "refseq_name": "Fanconi anemia group G protein homolog isoform 2", "refseq_ac": [ { "id": "NP_001156705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156705", "type": "external" } ], "gene_names_uniprotkb": "Fancg", "gene_names_refseq": "Fancg; Xrcc9", "protein_names_uniprotkb": "Fanconi anemia group G protein homolog; Protein FACG", "protein_names_refseq": "Fanconi anemia group G protein homolog isoform 2; fanconi anemia group G protein homolog", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group G (Disease Ontology:DOID:0111086); Fanconi anemia (Disease Ontology:DOID:13636); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:60534); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11093276;11823446;11918676;34428180", "class_list": "", "function": "Characterization and expression of the murine Fanconi anaemia gene product, [RefSeq, PubMed]; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity)., [UniProtKB]; Mice deficient in Fancg were not anemic, but showed hypogonadism, impaired fertility, and hypersensitivity to mitomycin C, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AG34", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0007286 spermatid development;GO:0006974 DNA damage response;GO:0001541 ovarian follicle development;GO:0007005 mitochondrion organization;GO:0009314 response to radiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQR6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXW0-1", "uniprot_id": [ { "id": "FBXL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXW0", "type": "external" } ], "mass": 59268.0, "length": 535, "protein_name": "F-box/LRR-repeat protein 6", "gene_name": "Fbxl6", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 6", "refseq_ac": [ { "id": "NP_038937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038937", "type": "external" } ], "gene_names_uniprotkb": "Fbxl6; Fbl6; MNCb-1275", "gene_names_refseq": "Fbl6; Fbxl6", "protein_names_uniprotkb": "F-box/LRR-repeat protein 6; F-box and leucine-rich repeat protein 6; F-box protein FBL6", "protein_names_refseq": "F-box protein FBL6; F-box protein containing leucine repeats 6; F-box/LRR-repeat protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:30840)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10531037;30084848;31219806;34428180;37653031", "class_list": "", "function": "Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice. Erratum:[Exp Mol Med. 2023 Oct;55(10):2281-2286. doi: 10.1038/s12276-023-01116-8. PMID: 37783772], [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJD7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QXW0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM9-1", "uniprot_id": [ { "id": "FBX16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZM9", "type": "external" } ], "mass": 38987.0, "length": 334, "protein_name": "F-box only protein 16", "gene_name": "Fbxo16", "organism": "Mouse", "refseq_name": "F-box only protein 16 isoform 1", "refseq_ac": [ { "id": "NP_056610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056610", "type": "external" } ], "gene_names_uniprotkb": "Fbxo16; Fbx16", "gene_names_refseq": "4932435C24Rik; Fbx16; Fbxo16", "protein_names_uniprotkb": "F-box only protein 16", "protein_names_refseq": "F-box only protein 16 isoform 1; F-box only protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:50759)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10531037", "class_list": "", "function": "Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition. Controls the ubiquitination and degradation of hnRNPL. Negatively regulates NF-kappa-B signaling by mediating the polyubiquitination and degradation of RELA. Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP74;Q8C5V6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2G0-1", "uniprot_id": [ { "id": "FEM1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2G0", "type": "external" } ], "mass": 70223.0, "length": 627, "protein_name": "Protein fem-1 homolog B", "gene_name": "Fem1b", "organism": "Mouse", "refseq_name": "protein fem-1 homolog B", "refseq_ac": [ { "id": "NP_034323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034323", "type": "external" } ], "gene_names_uniprotkb": "Fem1b; F1aa; Kiaa0396", "gene_names_refseq": "Fem1b; mKIAA0396", "protein_names_uniprotkb": "Protein fem-1 homolog B; F1A-alpha; FEM1-beta; FEM1b; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; mt-Fem", "protein_names_refseq": "F1A-alpha; FEM1-beta; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; mt-Fem; protein fem-1 homolog B", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14155); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10542291;15601915;16024793;18816836;20952268;21723927;21952136;22872234;25428506;30084848;30779550;31219806;32941802;34428180;34562363;9828124", "class_list": "", "function": "Fem1b is a binding partner of Ankrd37, and their interaction resulted in Ankrd37 degradation through the ubiquitin-mediated proteolysis pathway., [RefSeq, PubMed]; Increased Fem1b is associated with intestinal neoplasia., [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (By similarity). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (PubMed:32941802, PubMed:34562363). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (PubMed:34562363). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (By similarity). Promotes ubiquitination and degradation of ANKRD37 (PubMed:21723927). Promotes ubiquitination and degradation of SLBP (By similarity). Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity). Also involved in glucose homeostasis in pancreatic islet (PubMed:16024793). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV57;Q3ULQ3;Q3V148;Q80U13;Q99NC9;Q9QZL3", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0060743 epithelial cell maturation involved in prostate gland development;GO:2000001 regulation of DNA damage checkpoint;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2G0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2I2-1", "uniprot_id": [ { "id": "FKB1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2I2", "type": "external" } ], "mass": 11798.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1B", "gene_name": "Fkbp1b", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1", "refseq_ac": [ { "id": "NP_058559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058559", "type": "external" } ], "gene_names_uniprotkb": "Fkbp1b", "gene_names_refseq": "12.6kDa; FKBP12.6; Fkbp1b; calstabin2", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; 5.2.1.8; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; Immunophilin FKBP12.6; PPIase FKBP1B; Rotamase", "protein_names_refseq": "12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; PPIase FKBP1B; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1; peptidyl-prolyl cis-trans isomerase FKBP1B; rotamase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); Graves' disease (Disease Ontology:DOID:12361); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:14226); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11907581;12837242;28077437;29682889;32151269;9880681", "class_list": "", "function": "During exercise, RyR2 phosphorylation by protein kinase A dissociates FKBP12.6 from the channel, increasing Ca(2+) release and cardiac contractility. FKBP12.6(-/-) mice showed exercise-induced arrhythmias., [RefSeq, PubMed]; FKBP12.6 plays protective role in cardiac hypertrophy through inhibiting Ca(2+) /calmodulin-mediated signalling pathways., [RefSeq, PubMed]; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB]; Modulates cardiac excitation-contraction coupling, [RefSeq, PubMed]; Role of lateral amygdala calstabin2 in regulation of fear memory. Publication Status: Online-Only, [RefSeq, PubMed]; The heart contraction is controlled by the Ca2+-induced Ca2+ release between L-type Ca2+ channels and ryanodine receptors. RyRs became more sensitive to Ca2+ triggers without FKBP12.6, leading to ventricular arrthymias., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" } ], "go_molecular_function": "GO:0030551 cyclic nucleotide binding;GO:0005102 signaling receptor binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum;GO:0034704 calcium channel complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0050849 negative regulation of calcium-mediated signaling;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0051284 positive regulation of sequestering of calcium ion;GO:0006939 smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z2I2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17439-1", "uniprot_id": [ { "id": "GBA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17439", "type": "external" } ], "mass": 57622.0, "length": 515, "protein_name": "Lysosomal acid glucosylceramidase", "gene_name": "Gba1", "organism": "Mouse", "refseq_name": "lysosomal acid glucosylceramidase isoform 1 precursor", "refseq_ac": [ { "id": "NP_001070879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070879", "type": "external" } ], "gene_names_uniprotkb": "Gba1; Gba", "gene_names_refseq": "GCase; GC; GLUC; Gba1; Gba; betaGC", "protein_names_uniprotkb": "Lysosomal acid glucosylceramidase; 2.4.1.-; 3.2.1.-; 3.2.1.45; 3.2.1.46; Acid beta-glucosidase; Beta-glucocerebrosidase; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Lysosomal acid GCase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; Lysosomal glycosylceramidase; SGTase", "protein_names_refseq": "D-glucosyl-N-acylsphingosine glucohydrolase; SGTase; acid beta glucosidase; beta-glucocerebrosidase; cholesterol glucosyltransferase; cholesteryl-beta-glucosidase; glucosidase, beta, acid; glucosylceramidase; lysosomal acid GCase; lysosomal acid glucosylceramidase isoform 1 precursor; lysosomal acid glucosylceramidase; lysosomal cholesterol glycosyltransferase; lysosomal galactosylceramidase; lysosomal glycosylceramidase", "tax_id": 10090, "disease": "Netherton syndrome (Disease Ontology:DOID:0050474); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); Gaucher's disease type I (Disease Ontology:DOID:0110957); Gaucher's disease type II (Disease Ontology:DOID:0110958); Gaucher's disease type III (Disease Ontology:DOID:0110959); Gaucher's disease perinatal lethal (Disease Ontology:DOID:0110960); Gaucher's disease type IIIC (Disease Ontology:DOID:0112250); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); Gaucher's disease (Disease Ontology:DOID:1926); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:14466); (R-MMU-9840310)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1317175;1594045;16075062;16170054;19349973;21750661;22665763;24211208;25428506;25605945;26740625;27378698;2740343;27789271;30899004;31219806", "class_list": "glycogene;glycosylhydrolase", "function": "Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose (PubMed:24211208). Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (By similarity). Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol (PubMed:24211208). GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) (By similarity). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (By similarity). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol (By similarity). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers (By similarity). Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q78NR7", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0005124 scavenger receptor binding;GO:0008422 beta-glucosidase activity;GO:0005102 signaling receptor binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0098773 skin epidermis development;GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0042391 regulation of membrane potential;GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P17439-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Y8-1", "uniprot_id": [ { "id": "GBRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Y8", "type": "external" } ], "mass": 53407.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-1", "gene_name": "Gabrg1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034382", "type": "external" } ], "gene_names_uniprotkb": "Gabrg1", "gene_names_refseq": "GabaA/BZ; GabaA; Gabrg1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1; GABAAR subunit gamma-1", "protein_names_refseq": "GABA(A) receptor subunit gamma-1; GABAAR subunit gamma-1; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1; gamma-aminobutyric acid receptor subunit gamma-1 isoform 1 precursor; gamma-aminobutyric acid receptor subunit gamma-1", "tax_id": 10090, "disease": "trigeminal neuralgia (Disease Ontology:DOID:12098)", "pathway": " (mmu:14405)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33300544;9527017", "class_list": "", "function": "Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHM6", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0Y8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48316-1", "uniprot_id": [ { "id": "GA45A_MOUSE", "url": "https://www.uniprot.org/uniprot/P48316", "type": "external" } ], "mass": 18339.0, "length": 165, "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 alpha", "gene_name": "Gadd45a", "organism": "Mouse", "refseq_name": "growth arrest and DNA damage-inducible protein GADD45 alpha", "refseq_ac": [ { "id": "NP_031862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031862", "type": "external" } ], "gene_names_uniprotkb": "Gadd45a; Ddit1; Gadd45", "gene_names_refseq": "Ddit1; GADD45; Gadd45a", "protein_names_uniprotkb": "Growth arrest and DNA damage-inducible protein GADD45 alpha; DDIT-1; DNA damage-inducible transcript 1 protein", "protein_names_refseq": "DDIT-1; DNA damage-inducible transcript 1 protein; DNA-damage-inducible transcript 1; Gadd45alpha; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible, alpha", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:13197); (R-MMU-6804114)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15735649;21750661;31219806;34428180;37421415;37511062;37807064;38473843;7509226;8139541", "class_list": "", "function": "Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer's Disease Hallmarks. Publication Status: Online-Only, [RefSeq, PubMed]; GADD45A and GADD45B as Novel Biomarkers Associated with Chromatin Regulators in Renal Ischemia-Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood., [RefSeq, PubMed]; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0019900 kinase binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0006469 negative regulation of protein kinase activity;GO:0042770 signal transduction in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48316-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3KML8-1", "uniprot_id": [ { "id": "GFY_MOUSE", "url": "https://www.uniprot.org/uniprot/J3KML8", "type": "external" } ], "mass": 53786.0, "length": 504, "protein_name": "Golgi-associated olfactory signaling regulator", "gene_name": "Gfy", "organism": "Mouse", "refseq_name": "Golgi-associated olfactory signaling regulator precursor", "refseq_ac": [ { "id": "NP_001182184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182184", "type": "external" } ], "gene_names_uniprotkb": "Gfy; Gm581; Goofy", "gene_names_refseq": "Gfy; Gm2515; Gm581; Goofy", "protein_names_uniprotkb": "Golgi-associated olfactory signaling regulator; Golgi protein in olfactory neurons; Goofy", "protein_names_refseq": "Golgi protein in olfactory neurons; Golgi-associated olfactory signaling regulator precursor; protein Goofy", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039953)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23926254", "class_list": "", "function": "Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling., [UniProtKB, PubMed]; These results demonstrated that Goofy plays an important role in establishing the acuity of olfactory sensory signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007608 sensory perception of smell;GO:1905515 non-motile cilium assembly;GO:0097499 protein localization to non-motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "J3KML8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54818-1", "uniprot_id": [ { "id": "GALC_MOUSE", "url": "https://www.uniprot.org/uniprot/P54818", "type": "external" } ], "mass": 77256.0, "length": 684, "protein_name": "Galactocerebrosidase", "gene_name": "Galc", "organism": "Mouse", "refseq_name": "galactocerebrosidase precursor", "refseq_ac": [ { "id": "NP_032105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032105", "type": "external" } ], "gene_names_uniprotkb": "Galc", "gene_names_refseq": "2310068B06Rik; A930008M05Rik; Gacy; Galc; twitcher; twi", "protein_names_uniprotkb": "Galactocerebrosidase; 3.2.1.46; GALCERase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase", "protein_names_refseq": "GALCERase; galactocerebrosidase precursor; galactocerebrosidase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase", "tax_id": 10090, "disease": "Krabbe disease (Disease Ontology:DOID:10587); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:14420); (R-MMU-9840310)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10861297;21750661;21876145;34428180;38937968;8769874", "class_list": "glycogene;glycosylhydrolase", "function": "Deficiency of galactosyl-ceramidase in adult oligodendrocytes worsens disease severity during chronic experimental allergic encephalomyelitis., [RefSeq, PubMed]; Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:10861297, PubMed:8769874). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes galactosylceramidase, the lysosomal hydryolase involved in the catabolism of galactosylceramide. Mutations in this gene result in slow growth, tremors and hind leg weakness, collectively termed as the 'twitcher' phenotype. In humans, deficiency of this gene product causes a lysosomal storage disorder known as Krabbe disease. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35151;Q3U3H7", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0042552 myelination;GO:0006683 galactosylceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54818-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97402-1", "uniprot_id": [ { "id": "GCNT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97402", "type": "external" } ], "mass": 45697.0, "length": 401, "protein_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase", "gene_name": "Gcnt2", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A", "refseq_ac": [ { "id": "NP_032131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032131", "type": "external" } ], "gene_names_uniprotkb": "Gcnt2", "gene_names_refseq": "5330430K10Rik; Gcnt2; IGnTA; IGnTB; IGnTC; IGnT", "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; 2.4.1.150; I-branching enzyme; IGNT; Large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase; N-acetylglucosaminyltransferase", "protein_names_refseq": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; beta-1,6-N-acetylglucosaminyltransferase; glucosaminyl (N-acetyl) transferase 2, I-branching enzyme; glucosaminyltransferase, I-branching enzyme; large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase", "tax_id": 10090, "disease": "cataract 13 with adult i phenotype (Disease Ontology:DOID:0110242); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:14538)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14672974;17591617;21750661;24105809;9134435", "class_list": "glycogene;glycosyltransferase", "function": "Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans (By similarity). Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells (By similarity)., [UniProtKB, UniProtKB]; Molecular cloning and analysis of expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase, [RefSeq, PubMed]; These data clearly suggest that GCNT2 functions in vivo together with beta3GnT2 to determine poly-N-acetyllactosamine (PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6T5E3", "ec_number_list": [ { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 2877, "hit_score": 0.6, "record_id": "P97402-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J23-1", "uniprot_id": [ { "id": "GHDC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J23", "type": "external" } ], "mass": 58508.0, "length": 532, "protein_name": "GH3 domain-containing protein", "gene_name": "Ghdc", "organism": "Mouse", "refseq_name": "GH3 domain-containing protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_114077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114077", "type": "external" } ], "gene_names_uniprotkb": "Ghdc; D11lgp1e; Lgp1", "gene_names_refseq": "D11Lgp1e; Ghdc", "protein_names_uniprotkb": "GH3 domain-containing protein", "protein_names_refseq": "D11lgp1; GH3 domain-containing protein isoform 1 precursor; GH3 domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:80860); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11161808;11735219;21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A5D7;Q99J92", "ec_number_list": [], "go_molecular_function": "GO:0016881 acid-amino acid ligase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99J23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE33-1", "uniprot_id": [ { "id": "GD1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE33", "type": "external" } ], "mass": 42318.0, "length": 370, "protein_name": "Ganglioside-induced differentiation-associated protein 1-like 1", "gene_name": "Gdap1l1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gdap1l1; Gdap1l", "gene_names_refseq": "", "protein_names_uniprotkb": "Ganglioside-induced differentiation-associated protein 1-like 1; GDAP1-L1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;33300544;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5I0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VE33-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMI3-1", "uniprot_id": [ { "id": "GGA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMI3", "type": "external" } ], "mass": 77973.0, "length": 718, "protein_name": "ADP-ribosylation factor-binding protein GGA3", "gene_name": "Gga3", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-binding protein GGA3 isoform 1", "refseq_ac": [ { "id": "NP_766636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766636", "type": "external" } ], "gene_names_uniprotkb": "Gga3; Kiaa0154", "gene_names_refseq": "C230037M19Rik; Gga3; mKIAA0154", "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3", "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA3 isoform 1; ADP-ribosylation factor-binding protein GGA3; golgi-localized, gamma ear-containing, ARF-binding protein 3", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:260302); (R-MMU-8875656)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11950392;20484053;21750661;22645316;22836275;27192432;30084848;33208500;34428180", "class_list": "", "function": "Depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury, [RefSeq, PubMed]; GGA3 plays a key role in GABAergic transmission. GGA3 deletion results in decreased anxiety-like behaviors and increased BACE1 levels. Publication Status: Online-Only, [RefSeq, PubMed]; GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery, [RefSeq, PubMed]; Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings., [RefSeq, PubMed]; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (By similarity). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1Y0;Q80U71", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:1902430 negative regulation of amyloid-beta formation;GO:0031647 regulation of protein stability;GO:0043001 Golgi to plasma membrane protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BMI3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01216-1", "uniprot_id": [ { "id": "GLHA_MOUSE", "url": "https://www.uniprot.org/uniprot/P01216", "type": "external" } ], "mass": 13565.0, "length": 120, "protein_name": "Glycoprotein hormones alpha chain", "gene_name": "Cga", "organism": "Mouse", "refseq_name": "glycoprotein hormones alpha chain precursor", "refseq_ac": [ { "id": "NP_034019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034019", "type": "external" } ], "gene_names_uniprotkb": "Cga", "gene_names_refseq": "CG-alpha; Cga; FSHA; GPHA1; GPHalpha; HCG; LHA; Tsha; aGSU; alpha-GSU; alphaGSU; alphaSU", "protein_names_uniprotkb": "Glycoprotein hormones alpha chain; Anterior pituitary glycoprotein hormones common subunit alpha; FSH-alpha; Follicle-stimulating hormone alpha chain; Follitropin alpha chain; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; TSH-alpha; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain", "protein_names_refseq": "FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; follicle-stimulating hormone alpha chain; follitropin alpha chain; glycoprotein hormones alpha chain precursor; glycoprotein hormones alpha chain; luteinizing hormone alpha chain; lutropin alpha chain; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612); Leydig cell tumor (Disease Ontology:DOID:2696)", "pathway": " (mmu:12640); (R-MMU-193048); (R-MMU-193993); (R-MMU-209822); (R-MMU-209968); (R-MMU-375281); (R-MMU-418555); (R-MMU-8866910); (R-MMU-975578)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12112597;21750661;23371388;2466623;6177696;6272299", "class_list": "", "function": "Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P11963;Q5M8P4", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0016913 follicle-stimulating hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016914 follicle-stimulating hormone complex;GO:0061696 pituitary gonadotropin complex;GO:0005576 extracellular region", "go_biological_process": "GO:0030878 thyroid gland development;GO:0032275 luteinizing hormone secretion;GO:0046621 negative regulation of organ growth;GO:0046884 follicle-stimulating hormone secretion;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01216-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZW7-1", "uniprot_id": [ { "id": "GBRP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZW7", "type": "external" } ], "mass": 50436.0, "length": 440, "protein_name": "Gamma-aminobutyric acid receptor subunit pi", "gene_name": "Gabrp", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit pi precursor", "refseq_ac": [ { "id": "NP_666129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666129", "type": "external" } ], "gene_names_uniprotkb": "Gabrp", "gene_names_refseq": "Gabrp", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi; GABAAR subunit pi", "protein_names_refseq": "GABA(A) receptor subunit pi; GABAAR subunit pi; gamma-aminobutyric acid (GABA) A receptor, pi; gamma-aminobutyric acid receptor subunit pi precursor; gamma-aminobutyric acid receptor subunit pi", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:216643)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22168837", "class_list": "", "function": "Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (By similarity). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonistrated that GABArho receptors expression in in aspiny, medium spiny neurons and GFAP-positive cells in the neostriatum., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUT6", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QZW7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLF1-1", "uniprot_id": [ { "id": "GBRT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLF1", "type": "external" } ], "mass": 72799.0, "length": 638, "protein_name": "Gamma-aminobutyric acid receptor subunit theta", "gene_name": "Gabrq", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit theta isoform b precursor", "refseq_ac": [ { "id": "NP_065234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065234", "type": "external" } ], "gene_names_uniprotkb": "Gabrq", "gene_names_refseq": "Gabrq", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit theta; GABA(A) receptor subunit theta; GABAAR subunit theta", "protein_names_refseq": "GABAAR subunit theta; gamma-aminobutyric acid (GABA) A receptor, subunit theta; gamma-aminobutyric acid receptor subunit theta isoform b precursor; gamma-aminobutyric acid receptor subunit theta", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:57249); (R-MMU-977443)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10804200;21750661;22690081;22872234;31219806;34428180", "class_list": "", "function": "GABRQ plays important roles in hepatocellular carcinoma development and progression, [RefSeq, PubMed]; Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JLF1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZF3-1", "uniprot_id": [ { "id": "GBA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZF3", "type": "external" } ], "mass": 103294.0, "length": 918, "protein_name": "Non-lysosomal glucosylceramidase", "gene_name": "Gba2", "organism": "Mouse", "refseq_name": "non-lysosomal glucosylceramidase isoform 1", "refseq_ac": [ { "id": "NP_766280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766280", "type": "external" } ], "gene_names_uniprotkb": "Gba2; Kiaa1605", "gene_names_refseq": "F630034E04; Gba2", "protein_names_uniprotkb": "Non-lysosomal glucosylceramidase; 2.4.1.-; 3.2.1.-; 3.2.1.45; 3.2.1.46; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Glucosylceramidase 2; NLGase; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glycosylceramidase", "protein_names_refseq": "NLGase; beta-glucocerebrosidase 2; beta-glucosidase 2; bile acid beta-glucosidase GBA2; bile acid glucosyl transferase GBA2; cholesterol glucosyltransferase GBA2; cholesteryl-beta-glucosidase GBA2; glucosidase, beta (bile acid) 2; glucosylceramidase 2; non-lysosomal cholesterol glycosyltransferase; non-lysosomal galactosylceramidase; non-lysosomal glucosylceramidase isoform 1; non-lysosomal glucosylceramidase; non-lysosomal glycosylceramidase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 46 (Disease Ontology:DOID:0110798)", "pathway": " (mmu:230101); (R-MMU-9840310)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17080196;21183079;21750661;23250757;25803043;26724485;28258214;30662006;31299418;32144204;40885482", "class_list": "glycogene;glycosylhydrolase", "function": "GBA2 is a glucosylceramidase whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease, [RefSeq, PubMed]; In heterozygous GBA1 mutant mice, there was also significantly reduced GBA2 GCase enzyme activity specifically within the hippocampus. Such reductions in GBA2 GCase enzyme could contribute to the pathological and behavioural effects seen., [RefSeq, PubMed]; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17080196, PubMed:23250757). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (PubMed:23250757). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (PubMed:25803043). Also involved in the transglucosylation of cholesterol, transferring glucose from GlcCer, thereby modifying its water solubility and biological properties (PubMed:26724485, PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (PubMed:26724485, PubMed:32144204). May play a role in the metabolism of bile acids (PubMed:17080196). Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:17080196). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Results shed light on the molecular mechanism underlying the pathogenesis of GBA2-related hereditary spastic paraplegia (HSP), autosomal-recessive cerebellar ataxia (ARCA) and reveal species-specific differences in GBA2 function in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 66, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGM3;Q8BTN9", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0005975 carbohydrate metabolic process;GO:0007417 central nervous system development;GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q69ZF3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYH5-1", "uniprot_id": [ { "id": "GFOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYH5", "type": "external" } ], "mass": 42242.0, "length": 385, "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 2", "gene_name": "Gfod2", "organism": "Mouse", "refseq_name": "glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_081745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081745", "type": "external" } ], "gene_names_uniprotkb": "Gfod2", "gene_names_refseq": "5730466C23Rik; Gfod2", "protein_names_uniprotkb": "Glucose-fructose oxidoreductase domain-containing protein 2; 1.-.-.-", "protein_names_refseq": "glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor; glucose-fructose oxidoreductase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70575)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;18757743;21750661;34428180;40885482", "class_list": "", "function": "Promotes matrix assembly., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CYH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWY4-1", "uniprot_id": [ { "id": "GEMI7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWY4", "type": "external" } ], "mass": 14251.0, "length": 129, "protein_name": "Gem-associated protein 7", "gene_name": "Gemin7", "organism": "Mouse", "refseq_name": "gem-associated protein 7", "refseq_ac": [ { "id": "NP_081465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081465", "type": "external" } ], "gene_names_uniprotkb": "Gemin7", "gene_names_refseq": "2400008I04Rik; Gemin7", "protein_names_uniprotkb": "Gem-associated protein 7; Gemin-7", "protein_names_refseq": "gem-associated protein 7; gemin-7", "tax_id": 10090, "disease": "", "pathway": " (mmu:69731); (R-MMU-191859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17023415;21750661;25428506", "class_list": "", "function": "Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032797 SMN complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CWY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80SZ7-1", "uniprot_id": [ { "id": "GBG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80SZ7", "type": "external" } ], "mass": 7318.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "gene_name": "Gng5", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "refseq_ac": [ { "id": "NP_034448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034448", "type": "external" } ], "gene_names_uniprotkb": "Gng5; Gngt5", "gene_names_refseq": "G(y)5; Gng5", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 5 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14707); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "21750661;24599258;34428180;36255067;8858601", "class_list": "", "function": "G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/beta-catenin pathway., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]; Targeted disruption of the mouse Gng5 gene encoding the gamma5 subtype produces embryonic lethality associated with severe head and heart defects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30670;Q5I0W4;Q61015", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0031680 G-protein beta/gamma-subunit complex;GO:0005739 mitochondrion;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0072513 positive regulation of secondary heart field cardioblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80SZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0E6-1", "uniprot_id": [ { "id": "GBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0E6", "type": "external" } ], "mass": 66739.0, "length": 589, "protein_name": "Guanylate-binding protein 2", "gene_name": "Gbp2", "organism": "Mouse", "refseq_name": "guanylate-binding protein 2", "refseq_ac": [ { "id": "NP_034390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034390", "type": "external" } ], "gene_names_uniprotkb": "Gbp2", "gene_names_refseq": "Gbp2", "protein_names_uniprotkb": "Guanylate-binding protein 2; 3.6.5.-; GBP-2; GTP-binding protein 2; Guanine nucleotide-binding protein 2; Interferon-induced guanylate-binding protein 2; mGBP-2; mGBP2", "protein_names_refseq": "GBP-2; GTP-binding protein 2; guanine nucleotide-binding protein 2; guanylate nucleotide binding protein 2; guanylate-binding protein 1; guanylate-binding protein 2; interferon-induced guanylate-binding protein 2; mGBP-2; mGBP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14469); (R-MMU-9953170)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10386861;18025219;21750661;22645316;22872234;24715728;24739961;24788674;25153642;25428506;25605945;25774715;25774716;26495903;26740625;27693356;30062052;30084848;30779550;31219806;31599954;34428180;35820727;36210013;37507081;38636926;39337476;9858320;9862701", "class_list": "", "function": "GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis., [RefSeq, PubMed]; Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Confers protection to the protozoan pathogen Toxoplasma gondii (PubMed:18025219). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FK03;Q8CIC6;Q921N2;Q9R1I0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus;GO:0006605 protein targeting;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q9Z0E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q649-1", "uniprot_id": [ { "id": "GCNT4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q649", "type": "external" } ], "mass": 52832.0, "length": 455, "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4", "gene_name": "Gcnt4", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4", "refseq_ac": [ { "id": "NP_001159537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159537", "type": "external" } ], "gene_names_uniprotkb": "Gcnt4", "gene_names_refseq": "C2gnt3; Gcnt4; Gm279; Gm73", "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; 2.4.1.102; C2GnT3; Core 2-branching enzyme 3; Core2-GlcNAc-transferase 3", "protein_names_refseq": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; core 2 beta-1,6-N-acetylglucosaminyltransferase 3; core 2-branching enzyme 3; core2-GlcNAc-transferase 3; glucosaminyl (N-acetyl) transferase 3, mucin type pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:218476); (R-MMU-913709)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;22736280;30084848;38180297", "class_list": "glycogene;glycosyltransferase", "function": "CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner., [RefSeq, PubMed]; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity., [UniProtKB, UniProtKB]; N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0048729 tissue morphogenesis;GO:0060993 kidney morphogenesis;GO:0042403 thyroid hormone metabolic process;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q649-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58854-1", "uniprot_id": [ { "id": "GCP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58854", "type": "external" } ], "mass": 103469.0, "length": 905, "protein_name": "Gamma-tubulin complex component 3", "gene_name": "Tubgcp3", "organism": "Mouse", "refseq_name": "gamma-tubulin complex component 3", "refseq_ac": [ { "id": "NP_932148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932148", "type": "external" } ], "gene_names_uniprotkb": "Tubgcp3; Gcp3", "gene_names_refseq": "GCP3; Spc98p; Tubgcp3", "protein_names_uniprotkb": "Gamma-tubulin complex component 3; GCP-3", "protein_names_refseq": "GCP-3; gamma-tubulin complex component 3; spindle pole body protein; tubulin, gamma complex associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:259279); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15784680;21750661;25428506;28528544;30059200;31219806;34428180;34678516;35822049;40021952", "class_list": "", "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDQ9", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0005827 polar microtubule;GO:0000930 gamma-tubulin complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P58854-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CA72-1", "uniprot_id": [ { "id": "GAN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CA72", "type": "external" } ], "mass": 67671.0, "length": 597, "protein_name": "Gigaxonin", "gene_name": "Gan", "organism": "Mouse", "refseq_name": "gigaxonin", "refseq_ac": [ { "id": "NP_001074620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074620", "type": "external" } ], "gene_names_uniprotkb": "Gan", "gene_names_refseq": "A330045G18; Gan; gigaxonin", "protein_names_uniprotkb": "Gigaxonin", "protein_names_refseq": "gigaxonin", "tax_id": 10090, "disease": "giant axonal neuropathy 1 (Disease Ontology:DOID:0090068)", "pathway": " (mmu:209239); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12147674;16227972;16565160;18680552;21750661;22872234;23585478;27000625;31219806;34428180;36210013", "class_list": "", "function": "Disruption of gigaxonin results in an impaired ubiquitin-proteasome system leading to a substantial accumulation of toxic microtubule-associated protein MAP8 in the null mutants., [RefSeq, PubMed]; Gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments, [RefSeq, PubMed]; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Results identify gigaxonin as a ubiquitin scaffolding protein that controls MAP1B-LC degradation, and provide insight into the molecular mechanisms underlying human neurodegenerative disorders, [RefSeq, PubMed]; We demonstrate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal Intermediate filaments. Moreover,Intermediate filaments accumulation impairs mitochondrial motility and is associated with metabolic and oxidative stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CA72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K157-1", "uniprot_id": [ { "id": "GALM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K157", "type": "external" } ], "mass": 37799.0, "length": 342, "protein_name": "Galactose mutarotase", "gene_name": "Galm", "organism": "Mouse", "refseq_name": "galactose mutarotase", "refseq_ac": [ { "id": "NP_795937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795937", "type": "external" } ], "gene_names_uniprotkb": "Galm", "gene_names_refseq": "A530057M15Rik; Galm", "protein_names_uniprotkb": "Galactose mutarotase; 5.1.3.3; Aldose 1-epimerase", "protein_names_refseq": "aldose 1-epimerase; galactose mutarotase", "tax_id": 10090, "disease": "galactosemia 4 (Disease Ontology:DOID:0060969)", "pathway": " (mmu:319625); (R-MMU-70370)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20485683;21750661;34428180;37453647", "class_list": "", "function": "Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.3", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0004034 aldose 1-epimerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K157-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35118-1", "uniprot_id": [ { "id": "GFRA3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35118", "type": "external" } ], "mass": 44307.0, "length": 397, "protein_name": "GDNF family receptor alpha-3", "gene_name": "Gfra3", "organism": "Mouse", "refseq_name": "GDNF family receptor alpha-3 preproprotein", "refseq_ac": [ { "id": "NP_034410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034410", "type": "external" } ], "gene_names_uniprotkb": "Gfra3", "gene_names_refseq": "GFRalpha3; Gfra3", "protein_names_uniprotkb": "GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3", "protein_names_refseq": "GDNF family receptor alpha-3 preproprotein; GDNF family receptor alpha-3; GDNFR-alpha-3; GFR alpha-3", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:14587); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "36898840;9448325;9535755;9576965;9608533;9749804", "class_list": "", "function": "Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRalpha3., [RefSeq, PubMed]; Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor., [UniProtKB, UniProtKB]; This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand artemin to the ret receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35325;O55243;Q6NZC2;Q8C8L9", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0001764 neuron migration;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35118-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true } ]